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Patricia Gearhart

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TOP 3
Huseyin Saribasak; Patricia J Gearhart
Does DNA repair occur during somatic hypermutation?
Huseyin Saribasak; Dominik Schenten; William W Yang; Zheng Cao; Sven Kracker; Robert W Maul; Patricia J Gearhart
DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.
Huseyin Saribasak; David M Wilson; William Yang; Zheng Cao; Robert W Maul; Rhonda L McClure; Daniel R McNeill; Patricia J Gearhart
XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes.

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All Publications

2012: Huseyin Saribasak; Patricia J Gearhart
Does DNA repair occur during somatic hypermutation?
Seminars in immunology 2012;24(4):287-92.
2012: Huseyin Saribasak; Dominik Schenten; William W Yang; Zheng Cao; Sven Kracker; Robert W Maul; Patricia J Gearhart
DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.
The Journal of experimental medicine 2012;209(6):1075-81.
2011: Huseyin Saribasak; David M Wilson; William Yang; Zheng Cao; Robert W Maul; Rhonda L McClure; Daniel R McNeill; Patricia J Gearhart
XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes.
The Journal of experimental medicine 2011;208(11):2209-16.
2011: Leah E Cole; Patricia J Gearhart; Barbara J Mann; Katharina Richard; Kari Ann Shirey; Rose M Viscardi; Kirsty L Chesko; Yang Yang; Stefanie N Vogel
Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge.
Journal of leukocyte biology 2011;90(4):787-97.
2011: Kathryn A Pape; Justin J Taylor; Robert W Maul; Patricia J Gearhart; Marc K Jenkins
Different B cell populations mediate early and late memory during an endogenous immune response.
Science (New York, N.Y.) 2011;331(6021):1203-7.
2011: Robert W Maul; Huseyin Saribasak; Stella A Martomo; Rhonda L McClure; William Yang; Alexandra Vaisman; Hillary S Gramlich; David G Schatz; Roger Woodgate; David M Wilson; Patricia J Gearhart
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions.
Nature immunology 2011;12(1):70-6.
2010: Rahul M Kohli; Robert W Maul; Amy F Guminski; Rhonda L McClure; Kiran S Gajula; Huseyin Saribasak; Moira A McMahon; Robert Siliciano; Patricia J Gearhart; James T Stivers
Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.
The Journal of biological chemistry 2010;285(52):40956-64.
2010: Robert W Maul; Patricia J Gearhart
Controlling somatic hypermutation in immunoglobulin variable and switch regions.
Immunologic research 2010;47(1-3):113-22.
2010: Robert W Maul; Patricia J Gearhart
AID and somatic hypermutation.
Advances in immunology 2010;105():159-91.
2009: Rahul Kohli; Shaun R Abrams; Kiran S Gajula; Robert W Maul; Patricia J Gearhart; James T Stivers
A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.
The Journal of biological chemistry 2009;284(34):22898-904.
2009: Deepa Rajagopal; Robert W Maul; Amalendu Ghosh; Tirtha Chakraborty; Ahmed Amine Khamlichi; RANJAN SEN; Patricia J Gearhart
Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation.
The Journal of experimental medicine 2009;206(6):1237-44.
2009: Huseyin Saribasak; Deepa Rajagopal; Robert W Maul; Patricia J Gearhart
Hijacked DNA repair proteins and unchained DNA polymerases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):605-11.
2009: Patricia J Gearhart; Tomas Lindahl; Michael S Neuberger
Preface.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):561-2.
2009: Robert W Maul; Patricia J Gearhart
Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase?
The Journal of experimental medicine 2009;206(1):11-3.
2008: Patricia J Gearhart; RANJAN SEN
Regulating antibody diversity: taming a mutagen.
Molecular cell 2008;31(5):615-6.
2008: Stella A Martomo; Huseyin Saribasak; Masayuki Yokoi; Fumio Hanaoka; Patricia J Gearhart
Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.
DNA repair 2008;7(9):1603-8.
2008: Lynn M Heltemes-Harris; Patricia J Gearhart; Paritosh Ghosh; Dan Longo
Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion.
Molecular immunology 2008;45(6):1799-806.
2007: Rudaina H Alrefai; David B Winter; Vilhelm A Bohr; Patricia J Gearhart
Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene.
Molecular immunology 2007;44(11):2800-5.
2006: Patricia J Gearhart
Antibody wars: extreme diversity.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4235-6.
2006: Stella A Martomo; Patricia J Gearhart
Somatic hypermutation: subverted DNA repair.
Current opinion in immunology 2006;18(3):243-8.
2006: Stella A Martomo; William W Yang; Alexandra Vaisman; Alex Maas; Masayuki Yokoi; Jan H J Hoeijmakers; Fumio Hanaoka; Roger Woodgate; Patricia J Gearhart
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota.
DNA repair 2006;5(3):392-8.
2005: Mineaki Seki; Patricia J Gearhart; Richard D Wood
DNA polymerases and somatic hypermutation of immunoglobulin genes.
EMBO reports 2005;6(12):1143-8.
2005: Stella A Martomo; Dongtao Fu; William W Yang; Nikhil S Joshi; Patricia J Gearhart
Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7787-91.
2005: Vladimir I Mayorov; Igor Rogozin; Linda R Adkison; Patricia J Gearhart
DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7781-6.
2005: Stella A Martomo; William W Yang; Robert P Wersto; Tsuyoshi Ohkumo; Yuji Kondo; Masayuki Yokoi; Chikahide Masutani; Fumio Hanaoka; Patricia J Gearhart
Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(24):8656-61.
2005: Teresa M Wilson; Alexandra Vaisman; Stella A Martomo; Patsa Sullivan; Li Lan; Fumio Hanaoka; Akira Yasui; Roger Woodgate; Patricia J Gearhart
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.
The Journal of experimental medicine 2005;201(4):637-45.
2004: Joanne M Lumsden; Thomas McCarty; Lisa K Petiniot; Rhuna Shen; Carrolee Barlow; Thomas A Wynn; Herbert C Morse; Patricia J Gearhart; Anthony Wynshaw-Boris; Edward E Max; Richard J Hodes
Immunoglobulin class switch recombination is impaired in Atm-deficient mice.
The Journal of experimental medicine 2004;200(9):1111-21.
2004: Patricia J Gearhart
The birth of molecular immunology.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4259.
2004: Stella A Martomo; William W Yang; Patricia J Gearhart
A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination.
The Journal of experimental medicine 2004;200(1):61-8.
2004: Xianmin Zeng; George A Negrete; Cynthia Kasmer; William W Yang; Patricia J Gearhart
Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions.
The Journal of experimental medicine 2004;199(7):917-24.
2003: Patricia J Gearhart
B cells pay a price.
Oncogene 2003;22(35):5379-80.
2003: John P McDonald; Ekaterina G Frank; Brian S Plosky; Igor Rogozin; Chikahide Masutani; Fumio Hanaoka; Roger Woodgate; Patricia J Gearhart
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation.
The Journal of experimental medicine 2003;198(4):635-43.
2003: David B Winter; Quy H Phung; Xianmin Zeng; Erling Seeberg; Deborah E Barnes; Tomas Lindahl; Patricia J Gearhart
Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5558-62.
2002: Patricia J Gearhart
Immunology: the roots of antibody diversity.
Nature 2002;419(6902):29-31.
2001: Patricia J Gearhart; R D Wood
Emerging links between hypermutation of antibody genes and DNA polymerases.
Nature reviews. Immunology 2001;1(3):187-92.
2001: Karli Rosner; David B Winter; Gunhild Lange Skovgaard; Oshima Junko; Patricia J Gearhart; Vilhelm A Bohr
Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome.
Mechanisms of ageing and development 2001;122(11):1121-33.
2001: Karli Rosner; David B Winter; RE Tarone; Gunhild Lange Skovgaard; Vilhelm A Bohr; Patricia J Gearhart
Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.
Immunology 2001;103(2):179-87.
2001: Ekaterina G Frank; Agnes TISSIER; John P McDonald; V Rapić-Otrin; X Zeng; Patricia J Gearhart; Roger Woodgate
Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.
The EMBO journal 2001;20(11):2914-22.
2001: Xianmin Zeng; David B Winter; Cynthia Kasmer; Kenneth H Kraemer; Alan Lehmann; Patricia J Gearhart
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.
Nature immunology 2001;2(6):537-41.
2001: Karli Rosner; David B Winter; Cynthia Kasmer; Gunhild Lange Skovgaard; RE Tarone; Vilhelm A Bohr; Patricia J Gearhart
Impact of age on hypermutation of immunoglobulin variable genes in humans.
Journal of clinical immunology 2001;21(2):102-15.
2001: David B Winter; Patricia J Gearhart
Altered spectra of hypermutation in DNA repair-deficient mice.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1405):5-11.
2000: J Wittschieben; Mahmud K K Shivji; E Lalani; M A Jacobs; F Marini; Patricia J Gearhart; Ian Rosewell; Gordon Stamp; Richard D Wood
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.
Current biology : CB 2000;10(19):1217-20.
2000: Mark D Duncan; Tarik Tihan; David M Donovan; Quy H Phung; Daniel L Rowley; John W Harmon; Patricia J Gearhart; KIMBERLY DUNCAN
Esophagogastric adenocarcinoma in an E1A/E1B transgenic model involves p53 disruption.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2000;4(3):290-7.
2000: David B Winter; Quy H Phung; R D Wood; Patricia J Gearhart
Differential expression of DNA polymerase epsilon in resting and activated B lymphocytes is consistent with an in vivo role in replication and not repair.
Molecular immunology 2000;37(3-4):125-31.
1999: Rudaina H Alrefai; E J Beecham; Vilhelm A Bohr; Patricia J Gearhart
Less repair of pyrimidine dimers and single-strand breaks in genes by scid cells.
Biochemical and biophysical research communications 1999;264(3):878-82.
1999: Quy H Phung; David B Winter; Rudaina H Alrefai; Patricia J Gearhart
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3121-4.
1998: David B Winter; Patricia J Gearhart; Vilhelm A Bohr
Homogeneous rate of degradation of nuclear DNA during apoptosis.
Nucleic acids research 1998;26(19):4422-5.
1998: MT Tchorzewski; Mark D Duncan; Petra Nass; FG Qureshi; Patricia J Gearhart; RA Winchurch; John W Harmon
Characterization of an aFGF gene expression vector with therapeutic potential.
The Journal of surgical research 1998;77(2):99-103.
1998: David B Winter; Quy H Phung; Asad Umar; Sean M Baker; RE Tarone; K Tanaka; R Michael Liskay; Thomas A Kunkel; Vilhelm A Bohr; Patricia J Gearhart
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6953-8.
1998: Quy H Phung; David B Winter; A Cranston; RE Tarone; Vilhelm A Bohr; Richard Fishel; Patricia J Gearhart
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein.
The Journal of experimental medicine 1998;187(11):1745-51.
1998: David B Winter; Patricia J Gearhart
Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism.
Immunological reviews 1998;162():89-96.
1998: David B Winter; N Sattar; Patricia J Gearhart
The role of promoter-intron interactions in directing hypermutation.
Current topics in microbiology and immunology 1998;229():1-10.
1997: David B Winter; N Sattar; J J Mai; Patricia J Gearhart
Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene.
Molecular immunology 1997;34(5):359-66.
1995: David B Winter; Patricia J Gearhart
Somatic hypermutation: Another piece in the hypermutation puzzle.
Current biology : CB 1995;5(12):1345-6.
1995: Asad Umar; Patricia J Gearhart
Reciprocal homologous recombination in or near antibody VDJ genes.
European journal of immunology 1995;25(8):2392-400.
1992: Ann M Lawler; Asad Umar; Patricia J Gearhart
Linkage of two pseudogenes from V kappa 1 and V kappa 9 murine immunoglobulin families.
Molecular immunology 1992;29(3):295-301.
1991: Asad Umar; P A Schweitzer; N S Levy; John D Gearhart; Patricia J Gearhart
Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4902-6.
1990: S G Lebecque; Patricia J Gearhart
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.
The Journal of experimental medicine 1990;172(6):1717-27.
1990: S L Gleason; Patricia J Gearhart; Noel R Rose; R C Kuppers
Autoantibodies to thyroglobulin are encoded by diverse V-gene segments and recognize restricted epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1768-75.
1989: Ann M Lawler; J F Kearney; M Kuehl; Patricia J Gearhart
Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6744-7.
1989: N S Levy; U V Malipiero; S G Lebecque; Patricia J Gearhart
Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.
The Journal of experimental medicine 1989;169(6):2007-19.
1988: Patricia J Gearhart; Ann M Lawler; N S Levy; S G Lebecque; U V Malipiero
Generation of antibody diversity before and after immunization.
Annals of the New York Academy of Sciences 1988;546():57-62.
1987: U V Malipiero; N S Levy; Patricia J Gearhart
Somatic mutation in anti-phosphorylcholine antibodies.
Immunological reviews 1987;96():59-74.
1987: Ann M Lawler; P S Lin; Patricia J Gearhart
Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2454-8.
1987: G B Golding; Patricia J Gearhart; B W Glickman
Patterns of somatic mutations in immunoglobulin variable genes.
Genetics 1987;115(1):169-76.
1984: R M Perlmutter; S T Crews; R Douglas; G Sorensen; N Johnson; N Nivera; Patricia J Gearhart; L Hood
The generation of diversity in phosphorylcholine-binding antibodies.
Advances in immunology 1984;35():1-37.
1984: Patricia J Gearhart
The adaptable somatic repertoire.
Annales d'immunologie 1984;135C(1):137-42.
1983: Patricia J Gearhart; D F Bogenhagen
Clusters of point mutations are found exclusively around rearranged antibody variable genes.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(11):3439-43.
1983: J D Rodwell; Patricia J Gearhart; F Karush
Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphorylcholine antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1983;130(1):313-6.
1983: Patricia J Gearhart
The effect of somatic mutation on antibody affinity.
Annals of the New York Academy of Sciences 1983;418():171-6.
1981: S K Pierce; N A Speck; K Gleason; Patricia J Gearhart; H Köhler
Balb/c T cells have the potential to recognize the TEPC 15 prototype antibody and its somatic variants.
The Journal of experimental medicine 1981;154(4):1178-87.
1981: Patricia J Gearhart; John J Cebra
Most B cells that have switched surface immunoglobulin isotypes generate clones of cells that do not secrete IgM.
Journal of immunology (Baltimore, Md. : 1950) 1981;127(3):1030-4.
1981: Patricia J Gearhart; N D Johnson; R Douglas; L Hood
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts.
Nature 1981;291(5810):29-34.
1980: John J Cebra; Patricia J Gearhart; J F Halsey; J L Hurwitz; R D Shahin
Role of environmental antigens in the ontogeny of the secretory immune response.
Journal of the Reticuloendothelial Society 1980;28(Suppl):61s-71s.
1980: Patricia J Gearhart; J L Hurwitz; John J Cebra
Successive switching of antibody isotypes expressed within the lines of a B-cell clone.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(9):5424-8.
1979: Patricia J Gearhart; J J Cebra
Differentiated B lymphocytes. Potential to express particular antibody variable and constant regions depends on site of lymphoid tissue and antigen load.
The Journal of experimental medicine 1979;149(1):216-27.
1978: Patricia J Gearhart; J J Cebra
Idiotype sharing by murine strains differing in immunoglobulin allotype.
Nature 1978;272(5650):264-5.
1978: J J Cebra; R Emmons; Patricia J Gearhart; S M Robertson; J Tseng
Cellular parameters of the IgA response.
Advances in experimental medicine and biology 1978;107():19-28.
1977: R S Accolla; Patricia J Gearhart; N H Sigal; M P Cancro; N R Klinman
Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells.
European journal of immunology 1977;7(12):876-81.
1977: Patricia J Gearhart
Non-sequential expression of multiple immunoglobulin classes by isolated B-cell clones.
Nature 1977;269(5631):812-3.
1977: N H Sigal; A R Pickard; E S Metcalf; Patricia J Gearhart; N R Klinman
Expression of phosphorylcholine-specific B cells during murine development.
The Journal of experimental medicine 1977;146(4):933-48.
1977: J J Cebra; R Kamat; Patricia J Gearhart; S M Robertson; J Tseng
The secretory IgA system of the gut.
Ciba Foundation symposium 1977;(46):5-28.
1977: Patricia J Gearhart; N H Sigal; N R Klinman
The monoclonal anti-phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire.
The Journal of experimental medicine 1977;145(4):876-91.
1977: J J Cebra; Patricia J Gearhart; R Kamat; S M Robertson; J Tseng
The secretory immunoglobulin A response in the gut [proceedings].
Biochemical Society transactions 1977;5(5):1565-9.
1977: J J Cebra; Patricia J Gearhart; R Kamat; S M Robertson; J Tseng
Origin and differentiation of lymphocytes involved in the secretory IgA responses.
Cold Spring Harbor symposia on quantitative biology 1977;41 Pt 1():201-15.
1977: N R Klinman; N H Sigal; E S Metcalf; S K Pierce; Patricia J Gearhart
The interplay of evolution and environment in B-cell diversification.
Cold Spring Harbor symposia on quantitative biology 1977;41 Pt 1():165-73.
1976: N R Klinman; A R Pickard; N H Sigal; Patricia J Gearhart; E S Metcalf; S K Pierce
Assessing B cell diversification by antigen receptor and precursor cell analysis.
Annales d'immunologie 1976;127(3-4):489-502.
1976: N H Sigal; Patricia J Gearhart; J L Press; N R Klinman
Late acquisition of a germ line antibody specificity.
Nature 1976;259(5538):51-2.
1975: Patricia J Gearhart; N H Sigal; N R Klinman
Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(5):1707-11.
1975: N H Sigal; Patricia J Gearhart; N R Klinman
The frequency of phosphorylcholine-specific B cells in conventional and germfree BALB/C mice.
Journal of immunology (Baltimore, Md. : 1950) 1975;114(4):1354-8.
1975: Patricia J Gearhart; N H Sigal; N R Klinman
Heterogeneity of the BALB/c antiphosphorylcholine antibody response at the precursor cell level.
The Journal of experimental medicine 1975;141(1):56-71.