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Hiroyuki Arai

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Alzheimer Disease

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Amino Acid Sequence

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Co-Publications
Name
65
Aoki, Junken
45
Sasaki, Hidetada
27
Igarashi, Yasuo
19
Matsui, Toshifumi
18
Ishii, Masaharu
16
Hama, Kotaro
15
Inoue, Kenji
13
Okamura, Nobuyuki
13
Tsujimoto, Masafumi
12
Inoue, Keizo
12
Higuchi, Makoto
12
Maruyama, Masahiro
10
Higuchi, Susumu
10
Adachi, Hideki
9
Inoue, Takao

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Publications

TOP 3
Iwashita Masazumi; Makide Kumiko; Nonomura Taro; Misumi Yoshimasa; Otani Yuko; Ishida Mayuko; Taguchi Ryo; Tsujimoto Masafumi; Aoki Junken; Arai Hiroyuki; Ohwada Tomohiko
Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative.
Yoshida Motoki; Nakayama Katsutoshi; Yasuda Hiroyasu; Kubo Hiroshi; Kuwano Kazuyoshi; Arai Hiroyuki; Yamaya Mutsuo
Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells.
Morikawa Rei K; Aoki Junken; Kano Fumi; Murata Masayuki; Yamamoto Akitsugu; Tsujimoto Masafumi; Arai Hiroyuki
Intracellular phospholipase A1gamma (iPLA1gamma) is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complex.

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All Publications

2009: Iwashita Masazumi; Makide Kumiko; Nonomura Taro; Misumi Yoshimasa; Otani Yuko; Ishida Mayuko; Taguchi Ryo; Tsujimoto Masafumi; Aoki Junken; Arai Hiroyuki; Ohwada Tomohiko
Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative.
Journal of medicinal chemistry 2009;52(19):5837-63.
2009: Yoshida Motoki; Nakayama Katsutoshi; Yasuda Hiroyasu; Kubo Hiroshi; Kuwano Kazuyoshi; Arai Hiroyuki; Yamaya Mutsuo
Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells.
Respirology (Carlton, Vic.) 2009;14(7):1027-34.
2009: Morikawa Rei K; Aoki Junken; Kano Fumi; Murata Masayuki; Yamamoto Akitsugu; Tsujimoto Masafumi; Arai Hiroyuki
Intracellular phospholipase A1gamma (iPLA1gamma) is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complex.
The Journal of biological chemistry 2009;284(39):26620-30.
2009: Mogi Tatsushi; Kawakami Takuro; Arai Hiroyuki; Igarashi Yasuo; Matsushita Kazunobu; Mori Mihoko; Shiomi Kazuro; Omura Satoshi; Harada Shigeharu; Kita Kiyoshi
Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor.
Journal of biochemistry 2009;146(3):383-7.
2009: Ogawa Seiji; Urabe Daisuke; Yokokura Yoshiyuki; Arai Hiroyuki; Arita Makoto; Inoue Masayuki
Total synthesis and bioactivity of resolvin E2.
Organic letters 2009;11(16):3602-5.
2009: Maekawa Masashi; Inoue Takao; Kobuna Hiroyuki; Nishimura Taki; Gengyo-Ando Keiko; Mitani Shohei; Arai Hiroyuki
Functional analysis of GS28, an intra-Golgi SNARE, in Caenorhabditis elegans.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(8):1003-13.
2009: Ikeda Takeshi; Nakamura Miyuki; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Ferredoxin-NADP reductase from the thermophilic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6.
FEMS microbiology letters 2009;297(1):124-30.
2009: Sasaki Takahiko; Nakayama Katsutoshi; Yasuda Hiroyasu; Yoshida Motoki; Asamura Takaaki; Ohrui Takashi; Arai Hiroyuki; Araya Jun; Kuwano Kazuyoshi; Yamaya Mutsuo
A randomized, single-blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patients.
Journal of the American Geriatrics Society 2009;57(8):1453-7.
2009: Endo Tomoko; Kano Kuniyuki; Motoki Rie; Hama Kotaro; Okudaira Shinichi; Ishida Mayuko; Ogiso Hideo; Tanaka Masayuki; Matsuki Norio; Taguchi Ryo; Kanai Motomu; Shibasaki Masakatsu; Arai Hiroyuki; Aoki Junken
Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.
Journal of biochemistry 2009;146(2):283-93.
2009: Yamaya Mutsuo; Fujino Naoya; Kubo Hiroshi; Arai Hiroyuki
Effects of pneumococcal vaccination on hospitalization and exacerbations in elderly Japanese chronic obstructive pulmonary disease patients.
Geriatrics & gerontology international 2009;9(2):206-9.
2009: Fujiwara Hironori; Tabuchi Masahiro; Yamaguchi Takuji; Iwasaki Koh; Furukawa Katsutoshi; Sekiguchi Kyoji; Ikarashi Yasushi; Kudo Yukitsuka; Higuchi Makoto; Saido Takaomi C; Maeda Sumihiro; Takashima Akihiko; Hara Masahiko; Yaegashi Nobuo; Kase Yoshio; Arai Hiroyuki
A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.
Journal of neurochemistry 2009;109(6):1648-57.
2009: Freeman Shannon; Ebihara Satoru; Ebihara Takae; Niu Kaijun; Kohzuki Masahiro; Arai Hiroyuki; Butler James P
Olfactory stimuli and enhanced postural stability in older adults.
Gait & posture 2009;29(4):658-60.
2009: Asada Masanori; Ebihara Satoru; Yamanda Shinsuke; Niu Kaijun; Okazaki Tatsuma; Sora Ichiro; Arai Hiroyuki
Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation.
Neoplasia (New York, N.Y.) 2009;11(4):408-17.
2009: Yamanda Shinsuke; Ebihara Satoru; Asada Masanori; Okazaki Tatsuma; Niu Kaijun; Ebihara Takae; Koyanagi Akemi; Yamaguchi Noriko; Yagita Hideo; Arai Hiroyuki
Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade.
Blood 2009;113(15):3631-9.
2008: Miura Akane; Kameya Masafumi; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
A soluble NADH-dependent fumarate reductase in the reductive tricarboxylic acid cycle of Hydrogenobacter thermophilus TK-6.
Journal of bacteriology 2008;190(21):7170-7.
2008: Matsuda Shinji; Inoue Takao; Lee Hyeon-Cheol; Kono Nozomu; Tanaka Fumiharu; Gengyo-Ando Keiko; Mitani Shohei; Arai Hiroyuki
Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(8):879-88.
2008: Kanamori Takahiro; Inoue Takao; Sakamoto Taro; Gengyo-Ando Keiko; Tsujimoto Masafumi; Mitani Shohei; Sawa Hitoshi; Aoki Junken; Arai Hiroyuki
Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.
The EMBO journal 2008;27(12):1647-57.
2008: Narisawa Naoki; Haruta Shin; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Coexistence of antibiotic-producing and antibiotic-sensitive bacteria in biofilms is mediated by resistant bacteria.
Applied and environmental microbiology 2008;74(12):3887-94.
2008: Lee Hyeon-Cheol; Inoue Takao; Imae Rieko; Kono Nozomu; Shirae Shinichiro; Matsuda Shinji; Gengyo-Ando Keiko; Mitani Shohei; Arai Hiroyuki
Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.
Molecular biology of the cell 2008;19(3):1174-84.
2008: Nakamura Kazuhiro; Igarashi Koji; Ide Kazufumi; Ohkawa Ryunosuke; Okubo Shigeo; Yokota Hiromitsu; Masuda Akiko; Oshima Noriko; Takeuchi Takumi; Nangaku Masaomi; Okudaira Shinichi; Arai Hiroyuki; Ikeda Hitoshi; Aoki Junken; Yatomi Yutaka
Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation.
Clinica chimica acta; international journal of clinical chemistry 2008;388(1-2):51-8.
2008: Kono Nozomu; Inoue Takao; Yoshida Yasukazu; Sato Hiroyuki; Matsusue Tomokazu; Itabe Hiroyuki; Niki Etsuo; Aoki Junken; Arai Hiroyuki
Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo.
The Journal of biological chemistry 2008;283(3):1628-36.
2008: Taniguchi Miyako; Okayama Yuka; Hashimoto Yuki; Kitaura Miki; Jimbo Daiki; Wakutani Yosuke; Wada-Isoe Kenji; Nakashima Kenji; Akatsu Hiroyasu; Furukawa Katsutoshi; Arai Hiroyuki; Urakami Katsuya
Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease.
Dementia and geriatric cognitive disorders 2008;26(2):117-22.
2007: Ueda Yasufumi; Yamamoto Masahiro; Urasaki Takashi; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Sequencing and reverse transcription-polymerase chain reaction (RT-PCR) analysis of four hydrogenase gene clusters from an obligately autotrophic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6.
Journal of bioscience and bioengineering 2007;104(6):470-5.
2007: Hama Kotaro; Aoki Junken; Inoue Asuka; Endo Tomoko; Amano Tomokazu; Motoki Rie; Kanai Motomu; Ye Xiaoqin; Chun Jerold; Matsuki Norio; Suzuki Hiroshi; Shibasaki Masakatsu; Arai Hiroyuki
Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice.
Biology of reproduction 2007;77(6):954-9.
2007: Nakamura Kazuhiro; Takeuchi Takumi; Ohkawa Ryunosuke; Okubo Shigeo; Yokota Hiromitsu; Tozuka Minoru; Aoki Junken; Arai Hiroyuki; Ikeda Hitoshi; Ohshima Noriko; Kitamura Tadaichi; Yatomi Yutaka
Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients.
Annals of clinical biochemistry 2007;44(Pt 6):549-56.
2007: Shichiri Mototada; Takanezawa Yasukazu; Uchida Koji; Tamai Hiroshi; Arai Hiroyuki
Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity.
Brain research 2007;1182():106-15.
2007: Yamaguchi Noritaka; Koizumi Hiroyuki; Aoki Junken; Natori Yumiko; Nishikawa Kiyotaka; Natori Yasuhiro; Takanezawa Yasukazu; Arai Hiroyuki
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(10):1153-61.
2007: Watanabe Naoko; Ikeda Hitoshi; Nakamura Kazuhiro; Ohkawa Ryunosuke; Kume Yukio; Tomiya Tomoaki; Tejima Kazuaki; Nishikawa Takako; Arai Masahiro; Yanase Mikio; Aoki Junken; Arai Hiroyuki; Omata Masao; Fujiwara Kenji; Yatomi Yutaka
Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity.
Life sciences 2007;81(12):1009-15.
2007: Watanabe Naoko; Ikeda Hitoshi; Nakamura Kazuhiro; Ohkawa Ryunosuke; Kume Yukio; Aoki Junken; Hama Kotaro; Okudaira Shinichi; Tanaka Masayuki; Tomiya Tomoaki; Yanase Mikio; Tejima Kazuaki; Nishikawa Takako; Arai Masahiro; Arai Hiroyuki; Omata Masao; Fujiwara Kenji; Yatomi Yutaka
Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.
Journal of clinical gastroenterology 2007;41(6):616-23.
2007: Mori Ken; Kitayama Joji; Aoki Junken; Kishi Yasuhiro; Shida Dai; Yamashita Hiroharu; Arai Hiroyuki; Nagawa Hirokazu
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Virchows Archiv : an international journal of pathology 2007;451(1):47-56.
2007: Satoh Yumiko; Ohkawa Ryunosuke; Nakamura Kazuhiro; Higashi Katsumi; Kaneko Makoto; Yokota Hiromitsu; Aoki Junken; Arai Hiroyuki; Yuasa Yasuhito; Yatomi Yutaka
Lysophosphatidic acid protection against apoptosis in the human pre-B-cell line Nalm-6.
European journal of haematology 2007;78(6):510-7.
2007: Kameya Masafumi; Ikeda Takeshi; Nakamura Miyuki; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
A novel ferredoxin-dependent glutamate synthase from the hydrogen-oxidizing chemoautotrophic bacterium Hydrogenobacter thermophilus TK-6.
Journal of bacteriology 2007;189(7):2805-12.
2007: Nakamura Kazuhiro; Ohkawa Ryunosuke; Okubo Shigeo; Tozuka Minoru; Okada Mitsumasa; Aoki Shinya; Aoki Junken; Arai Hiroyuki; Ikeda Hitoshi; Yatomi Yutaka
Measurement of lysophospholipase D/autotaxin activity in human serum samples.
Clinical biochemistry 2007;40(3-4):274-7.
2007: Aoki Junken; Inoue Asuka; Makide Kumiko; Saiki Naoya; Arai Hiroyuki
Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family.
Biochimie 2007;89(2):197-204.
2007: Morikawa Rei; Tsujimoto Masafumi; Arai Hiroyuki; Aoki Junken
Phospholipase A(1) assays using a radiolabeled substrate and mass spectrometry.
Methods in enzymology 2007;434():1-13.
2006: Shibata Norihito; Jishage Kou-ichi; Arita Makoto; Watanabe Miho; Kawase Yosuke; Nishikawa Kiyotaka; Natori Yasuhiro; Inoue Hiroyasu; Shimano Hitoshi; Yamada Nobuhiro; Tsujimoto Masafumi; Arai Hiroyuki
Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2642-4.
2006: Kameya Masafumi; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Purification and properties of glutamine synthetase from Hydrogenobacter thermophilus TK-6.
Journal of bioscience and bioengineering 2006;102(4):311-5.
2006: He M; Ohrui T; Maruyama M; Tomita N; Nakayama K; Higuchi M; Furukawa K; Arai H
ACE activity in CSF of patients with mild cognitive impairment and Alzheimer disease.
Neurology 2006;67(7):1309-10.
2006: Yamamoto Masahiro; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Role of two 2-oxoglutarate:ferredoxin oxidoreductases in Hydrogenobacter thermophilus under aerobic and anaerobic conditions.
FEMS microbiology letters 2006;263(2):189-93.
2006: Ebihara Takae; Ebihara Satoru; Maruyama Masahiro; Kobayashi Mitsuru; Itou Azusa; Arai Hiroyuki; Sasaki Hidetada
A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction.
Journal of the American Geriatrics Society 2006;54(9):1401-6.
2006: Ebihara Takae; Ebihara Satoru; Watando Aya; Okazaki Tatsuma; Asada Masanori; Ohrui Takashi; Yamaya Mutsuo; Arai Hiroyuki
Effects of menthol on the triggering of the swallowing reflex in elderly patients with dysphagia.
British journal of clinical pharmacology 2006;62(3):369-71.
2006: Tsuda Satomi; Okudaira Shinichi; Moriya-Ito Keiko; Shimamoto Chie; Tanaka Masayuki; Aoki Junken; Arai Hiroyuki; Murakami-Murofushi Kimiko; Kobayashi Tetsuyuki
Cyclic phosphatidic acid is produced by autotaxin in blood.
The Journal of biological chemistry 2006;281(36):26081-8.
2006: Tanaka Masayuki; Okudaira Shinichi; Kishi Yasuhiro; Ohkawa Ryunosuke; Iseki Sachiko; Ota Masato; Noji Sumihare; Yatomi Yutaka; Aoki Junken; Arai Hiroyuki
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.
The Journal of biological chemistry 2006;281(35):25822-30.
2006: Hama Kotaro; Aoki Junken; Bandoh Koji; Inoue Asuka; Endo Tomoko; Amano Tomokazu; Suzuki Hiroshi; Arai Hiroyuki
Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus.
Life sciences 2006;79(18):1736-40.
2006: Okazaki Hiroaki; Tazoe Fumiko; Okazaki Sachiko; Isoo Naoyuki; Tsukamoto Kazuhisa; Sekiya Motohiro; Yahagi Naoya; Iizuka Yoko; Ohashi Ken; Kitamine Tetsuya; Tozawa Ryu-Ichi; Inaba Toshihiro; Yagyu Hiroaki; Okazaki Mitsuyo; Shimano Hitoshi; Shibata Norihito; Arai Hiroyuki; Nagai Ryo-Zo; Kadowaki Takashi; Osuga Jun-Ichi; Ishibashi Shun
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
Journal of lipid research 2006;47(9):1950-8.
2006: Suzuki Miho; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Gene structure and expression profile of cytochrome bc nitric oxide reductase from Hydrogenobacter thermophilus TK-6.
Bioscience, biotechnology, and biochemistry 2006;70(7):1666-71.
2006: Okazaki Hiroaki; Igarashi Masaki; Nishi Makiko; Tajima Makiko; Sekiya Motohiro; Okazaki Sachiko; Yahagi Naoya; Ohashi Ken; Tsukamoto Kazuhisa; Amemiya-Kudo Michiyo; Matsuzaka Takashi; Shimano Hitoshi; Yamada Nobuhiro; Aoki Junken; Morikawa Rei; Takanezawa Yasukazu; Arai Hiroyuki; Nagai Ryozo; Kadowaki Takashi; Osuga Jun-Ichi; Ishibashi Shun
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis.
Diabetes 2006;55(7):2091-7.
2006: Kishi Yasuhiro; Okudaira Shinichi; Tanaka Masayuki; Hama Kotaro; Shida Dai; Kitayama Joji; Yamori Takao; Aoki Junken; Fujimaki Takamitsu; Arai Hiroyuki
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.
The Journal of biological chemistry 2006;281(25):17492-500.
2006: Suzuki Miho; Hirai Tadao; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Purification, characterization, and gene cloning of thermophilic cytochrome cd1 nitrite reductase from Hydrogenobacter thermophilus TK-6.
Journal of bioscience and bioengineering 2006;101(5):391-7.
2006: Maruyama Masahiro; Tomita Naoko; Iwasaki Koh; Ootsuki Mari; Matsui Toshifumi; Nemoto Miyako; Okamura Nobuyuki; Higuchi Makoto; Tsutsui Miho; Suzuki Tomoko; Seki Takashi; Kaneta Tomohiro; Furukawa Katsutoshi; Arai Hiroyuki
Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease: a 12-week observer-blind, donepezil monotherapy controlled trial.
Journal of the American Geriatrics Society 2006;54(5):869-71.
2006: Watanabe Nobuo; Zmijewski Jaroslaw W; Takabe Wakako; Umezu-Goto Makiko; Le Goffe Claire; Sekine Azusa; Landar Aimee; Watanabe Akira; Aoki Junken; Arai Hiroyuki; Kodama Tatsuhiko; Murphy Michael P; Kalyanaraman Raman; Darley-Usmar Victor M; Noguchi Noriko
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells.
The American journal of pathology 2006;168(5):1737-48.
2006: Qian Lian; Xu Yong; Simper Ted; Jiang Guowei; Aoki Junken; Umezu-Goto Makiko; Arai Hiroyuki; Yu Shuangxing; Mills Gordon B; Tsukahara Ryoko; Makarova Natalia; Fujiwara Yuko; Tigyi Gabor; Prestwich Glenn D
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.
ChemMedChem 2006;1(3):376-83.
2006: Ikeda Takeshi; Ochiai Toshihiro; Morita Susumu; Nishiyama Ayako; Yamada Eio; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Anabolic five subunit-type pyruvate:ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6.
Biochemical and biophysical research communications 2006;340(1):76-82.
2006: Yamashita Hiroharu; Kitayama Joji; Shida Dai; Ishikawa Makoto; Hama Kotaro; Aoki Junken; Arai Hiroyuki; Nagawa Hirokazu
Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer.
Journal of surgical oncology 2006;93(1):30-5.
2005: Toyoda Koichi; Yoshizawa Yoichi; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
The role of two CbbRs in the transcriptional regulation of three ribulose-1,5-bisphosphate carboxylase/oxygenase genes in Hydrogenovibrio marinus strain MH-110.
Microbiology (Reading, England) 2005;151(Pt 11):3615-25.
2005: Kurusu Masayuki; Watanabe Kei; Nakazawa Toru; Seki Takashi; Arai Hiroyuki; Sasaki Hidetada; Fuse Nobuo; Tamai Makoto
Acupuncture for patients with glaucoma.
Explore (New York, N.Y.) 2005;1(5):372-6.
2005: Nakamura Toshiyuki; Shibata Norihito; Nishimoto-Shibata Takako; Feng Dongdong; Ikemoto Mamoru; Motojima Kiyoto; Iso-O Naoyuki; Tsukamoto Kazuhisa; Tsujimoto Masafumi; Arai Hiroyuki
Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13404-9.
2005: Kage Eriko; Hayashi Yu; Takeuchi Hideaki; Hirotsu Takaaki; Kunitomo Hirofumi; Inoue Takao; Arai Hiroyuki; Iino Yuichi; Kubo Takeo
MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans.
Current biology : CB 2005;15(17):1554-9.
2005: Nishimura Taki; Inoue Takao; Shibata Norihito; Sekine Azusa; Takabe Wakako; Noguchi Noriko; Arai Hiroyuki
Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(8):793-801.
2005: Ohrui Takashi; Tanaka Kazunori; Chiba Kazue; Matsui Toshifumi; Ebihara Satoru; He Mei; Tsuji Ichiro; Arai Hiroyuki; Sasaki Hidetada
Cognitive decline in patients with long-term domiciliary oxygen therapy.
The Tohoku journal of experimental medicine 2005;206(4):347-52.
2005: Horikawa Etsuo; Okamura Nobuyuki; Tashiro Manabu; Sakurada Yumiko; Maruyama Masahiro; Arai Hiroyuki; Yamaguchi Keiichiro; Sasaki Hidetada; Yanai Kazuhiko; Itoh Masatoshi
The neural correlates of driving performance identified using positron emission tomography.
Brain and cognition 2005;58(2):166-71.
2005: Ikeda Takeshi; Yamamoto Masahiro; Arai Hiroyuki; Ohmori Daijiro; Ishii Masaharu; Igarashi Yasuo
Two tandemly arranged ferredoxin genes in the Hydrogenobacter thermophilus genome: comparative characterization of the recombinant [4Fe-4S] ferredoxins.
Bioscience, biotechnology, and biochemistry 2005;69(6):1172-7.
2005: Arai Hiroyuki; Hayashi Michiko; Kuroi Azusa; Ishii Masaharu; Igarashi Yasuo
Transcriptional regulation of the flavohemoglobin gene for aerobic nitric oxide detoxification by the second nitric oxide-responsive regulator of Pseudomonas aeruginosa.
Journal of bacteriology 2005;187(12):3960-8.
2005: Maruyama Masahiro; Higuchi Makoto; Takaki Yoshie; Matsuba Yukio; Tanji Haruko; Nemoto Miyako; Tomita Naoki; Matsui Toshifumi; Iwata Nobuhisa; Mizukami Hiroaki; Muramatsu Shin-ichi; Ozawa Keiya; Saido Takaomi C; Arai Hiroyuki; Sasaki Hidetada
Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.
Annals of neurology 2005;57(6):832-42.
2005: Sakagami Hideki; Aoki Junken; Natori Yumiko; Nishikawa Kiyotaka; Kakehi Yoshiyuki; Natori Yasuhiro; Arai Hiroyuki
Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
The Journal of biological chemistry 2005;280(24):23084-93.
2005: Xu Yong; Aoki Junken; Shimizu Kumiko; Umezu-Goto Makiko; Hama Kotaro; Takanezawa Yasukazu; Yu Shuangxing; Mills Gordon B; Arai Hiroyuki; Qian Lian; Prestwich Glenn D
Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
Journal of medicinal chemistry 2005;48(9):3319-27.
2005: Matsui Toshifumi; Nemoto Miyako; Maruyama Masahiro; Yuzuriha Takefumi; Yao Hiroshi; Tanji Haruko; Ootsuki Mari; Tomita Naoki; Matsushita Sachio; Higuchi Susumu; Yoshida Yo-ichi; Seki Takashi; Iwasaki Koh; Furukawa Katsutoshi; Arai Hiroyuki
Plasma homocysteine and risk of coexisting silent brain infarction in Alzheimer's disease.
Neuro-degenerative diseases 2005;2(6):299-304.
2004: Shida Dai; Kitayama Joji; Yamaguchi Hironori; Hama Kotaro; Aoki Junken; Arai Hiroyuki; Yamashita Hiroharu; Mori Ken; Sako Akihiro; Konishi Tsuyoshi; Watanabe Toshiaki; Sakai Teruyuki; Suzuki Rika; Ohta Hideo; Takuwa Yoh; Nagawa Hirokazu
Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.
Experimental cell research 2004;301(2):168-78.
2004: Xu Yong; Tanaka Masayuki; Arai Hiroyuki; Aoki Junken; Prestwich Glenn D
Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors.
Bioorganic & medicinal chemistry letters 2004;14(21):5323-8.
2004: Ohrui T; Tomita N; Sato-Nakagawa T; Matsui T; Maruyama M; Niwa K; Arai H; Sasaki H
Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression.
Neurology 2004;63(7):1324-5.
2004: Shida Dai; Watanabe Toshiaki; Aoki Junken; Hama Kotaro; Kitayama Joji; Sonoda Hirofumi; Kishi Yasuhiro; Yamaguchi Hironori; Sasaki Shin; Sako Akihiro; Konishi Tsuyoshi; Arai Hiroyuki; Nagawa Hirokazu
Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer.
Laboratory investigation; a journal of technical methods and pathology 2004;84(10):1352-62.
2004: Inoue Takao; Sugimoto Asako; Suzuki Yuka; Yamamoto Masayuki; Tsujimoto Masafumi; Inoue Keizo; Aoki Junken; Arai Hiroyuki
Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13233-8.
2004: Yoshizawa Yoichi; Toyoda Koichi; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
CO2-responsive expression and gene organization of three ribulose-1,5-bisphosphate carboxylase/oxygenase enzymes and carboxysomes in Hydrogenovibrio marinus strain MH-110.
Journal of bacteriology 2004;186(17):5685-91.
2004: Shibata Mami; Ishii Junko; Koizumi Hiroyuki; Shibata Norihito; Dohmae Naoshi; Takio Koji; Adachi Hideki; Tsujimoto Masafumi; Arai Hiroyuki
Type F scavenger receptor SREC-I interacts with advillin, a member of the gelsolin/villin family, and induces neurite-like outgrowth.
The Journal of biological chemistry 2004;279(38):40084-90.
2004: Tanaka Masayuki; Kishi Yasuhiro; Takanezawa Yasukazu; Kakehi Yoshiyuki; Aoki Junken; Arai Hiroyuki
Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma.
FEBS letters 2004;571(1-3):197-204.
2004: Tamura Yoshiaki; Osuga Jun-ichi; Adachi Hideki; Tozawa Ryu-ichi; Takanezawa Yasukazu; Ohashi Ken; Yahagi Naoya; Sekiya Motohiro; Okazaki Hiroaki; Tomita Sachiko; Iizuka Yoko; Koizumi Hiroyuki; Inaba Toshihiro; Yagyu Hiroaki; Kamada Nobuo; Suzuki Hiroshi; Shimano Hitoshi; Kadowaki Takashi; Tsujimoto Masafumi; Arai Hiroyuki; Yamada Nobuhiro; Ishibashi Shun
Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
The Journal of biological chemistry 2004;279(30):30938-44.
2004: Inoue Takao; Arai Hiroyuki
[Lipid transfer proteins]
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(6):553-61.
2004: Tamaruya Yoko; Suzuki Masato; Kamura Goshu; Kanai Motomu; Hama Kotaro; Shimizu Kumiko; Aoki Junken; Arai Hiroyuki; Shibasaki Masakatsu
Identifying specific conformations by using a carbohydrate scaffold: discovery of subtype-selective LPA-receptor agonists and an antagonist.
Angewandte Chemie (International ed. in English) 2004;43(21):2834-7.
2004: Maruyama Masahiro; Matsui Toshifumi; Tanji Haruko; Nemoto Miyako; Tomita Naoki; Ootsuki Mari; Arai Hiroyuki; Sasaki Hidetada
Cerebrospinal fluid tau protein and periventricular white matter lesions in patients with mild cognitive impairment: implications for 2 major pathways.
Archives of neurology 2004;61(5):716-20.
2004: Yamaguchi Noritaka; Takanezawa Yasukazu; Koizumi Hiroyuki; Umezu-Goto Makiko; Aoki Junken; Arai Hiroyuki
Expression of NUDEL in manchette and its implication in spermatogenesis.
FEBS letters 2004;566(1-3):71-6.
2004: Hama Kotaro; Aoki Junken; Fukaya Masahiro; Kishi Yasuhiro; Sakai Teruyuki; Suzuki Rika; Ohta Hideo; Yamori Takao; Watanabe Masahiko; Chun Jerold; Arai Hiroyuki
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
The Journal of biological chemistry 2004;279(17):17634-9.
2004: Arai Hiroyuki; Sato-Nakagawa Takuma
[Dementia symptoms by electrolyte imbalance]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl():404-8.
2004: Kitayama Joji; Shida Dai; Sako Akihiro; Ishikawa Makoto; Hama Kotaro; Aoki Junken; Arai Hiroyuki; Nagawa Hirokazu
Over-expression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma.
Breast cancer research : BCR 2004;6(6):R640-6.
2004: Maruyama Masahiro; Matsui Toshifumi; Tanji Haruko; Ootsuki Mari; Nemoto Miyako; Tomita Naoki; Okamura Nobuyuki; Matsushita Sachio; Higuchi Susumu; Kodama Manabu; Arai Hiroyuki; Sasaki Hidetada
[Diagnosing the mild cognitive impairment stage of Alzheimer's disease]
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 2004;106(3):269-80.
2003: Yamamoto Masahiro; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Characterization of two different 2-oxoglutarate:ferredoxin oxidoreductases from Hydrogenobacter thermophilus TK-6.
Biochemical and biophysical research communications 2003;312(4):1297-302.
2003: Hiramatsu Tatsufumi; Sonoda Hirofumi; Takanezawa Yasukazu; Morikawa Rei; Ishida Mayuko; Kasahara Kohji; Sanai Yutaka; Taguchi Ryo; Aoki Junken; Arai Hiroyuki
Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta.
The Journal of biological chemistry 2003;278(49):49438-47.
2003: Tsunoda Makoto; Tenhunen Jukka; Tilgmann Carola; Arai Hiroyuki; Imai Kazuhiro
Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(11):923-7.
2003: Maruyama Masahiro; Arai Hiroyuki; Ootsuki Mari; Matsui Toshifumi; Sasaki Hidetada; Yamazaki Tetsuro; Kaneta Tomohiro; Okamura Toshifumi
Biomarkers in subjects with amnestic mild cognitive impairment.
Journal of the American Geriatrics Society 2003;51(11):1671-2.
2003: Qian Lian; Xu Yong; Arai Hiroyuki; Aoki Junken; McIntyre Thomas M; Prestwich Glenn D
Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid.
Organic letters 2003;5(24):4685-8.
2003: Horiguchi Masakuni; Arita Makoto; Kaempf-Rotzoll Daisy E; Tsujimoto Masafumi; Inoue Keizo; Arai Hiroyuki
pH-dependent translocation of alpha-tocopherol transfer protein (alpha-TTP) between hepatic cytosol and late endosomes.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(10):789-800.
2003: Ebihara Satoru; Saito Hiroshi; Kanda Akio; Nakajoh Mizue; Takahashi Hidenori; Arai Hiroyuki; Sasaki Hidetada
Impaired efficacy of cough in patients with Parkinson disease.
Chest 2003;124(3):1009-15.
2003: Matsui Toshifumi; Ebihara Takae; Ohrui Takashi; Yamaya Mutsuo; Arai Hiroyuki; Sasaki Hidetada
[Cerebrovascular disease and pneumonia in the elderly]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2003;40(4):325-8.
2003: Kaempf-Rotzoll Daisy E; Traber Maret G; Arai Hiroyuki
Vitamin E and transfer proteins.
Current opinion in lipidology 2003;14(3):249-54.
2003: Kaempf-Rotzoll D E; Horiguchi M; Hashiguchi K; Aoki J; Tamai H; Linderkamp O; Arai H
Human placental trophoblast cells express alpha-tocopherol transfer protein.
Placenta 2003;24(5):439-44.
2003: Koizumi Hiroyuki; Yamaguchi Noritaka; Hattori Mitsuharu; Ishikawa Tomo-O; Aoki Junken; Taketo Makoto M; Inoue Keizo; Arai Hiroyuki
Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis.
The Journal of biological chemistry 2003;278(14):12489-94.
2003: Gohda Jin; Nomura Yukiko; Suzuki Hisayo; Arai Hiroyuki; Akiyama Taishin; Inoue Jun-ichiro
Elimination of the vertebrate Escherichia coli Ras-like protein homologue leads to cell cycle arrest at G1 phase and apoptosis.
Oncogene 2003;22(9):1340-8.
2003: Chuakrut Songkran; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
Characterization of a bifunctional archaeal acyl coenzyme A carboxylase.
Journal of bacteriology 2003;185(3):938-47.
2003: Arai Hiroyuki
[Biomarkers, mild cognitive impairment and early diagnosis of Alzheimer's disease]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2003;40(1):22-6.
2003: Hasegawa Norio; Arai Hiroyuki; Igarashi Yasuo
Need for cytochrome bc1 complex for dissimilatory nitrite reduction of Pseudomonas aeruginosa.
Bioscience, biotechnology, and biochemistry 2003;67(1):121-6.
2003: Arai Hiroyuki; Mizutani Masayuki; Igarashi Yasuo
Transcriptional regulation of the nos genes for nitrous oxide reductase in Pseudomonas aeruginosa.
Microbiology (Reading, England) 2003;149(Pt 1):29-36.
2003: McIntyre Thomas M; Pontsler Aaron V; Silva Adriana R; St Hilaire Andy; Xu Yong; Hinshaw Jerald C; Zimmerman Guy A; Hama Kotaro; Aoki Junken; Arai Hiroyuki; Prestwich Glenn D
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):131-6.
2002: Hu XiaSheng; Okamura Nobuyuki; Arai Hiroyuki; Higuchi Makoto; Maruyama Masahiro; Itoh Masatoshi; Yamaguchi Keiichro; Sasaki Hidetada
Neuroanatomical correlates of low body weight in Alzheimer's disease: a PET study.
Progress in neuro-psychopharmacology & biological psychiatry 2002;26(7-8):1285-9.
2002: Aoki Junken; Taira Akitsu; Takanezawa Yasukazu; Kishi Yasuhiro; Hama Kotaro; Kishimoto Tatsuya; Mizuno Koji; Saku Keijiro; Taguchi Ryo; Arai Hiroyuki
Serum lysophosphatidic acid is produced through diverse phospholipase pathways.
The Journal of biological chemistry 2002;277(50):48737-44.
2002: Watanabe Tomomi; Nakagawa Kentaro; Ohata Shinya; Kitagawa Daiju; Nishitai Gen; Seo Jungwon; Tanemura Shuhei; Shimizu Nao; Kishimoto Hiroyuki; Wada Teiji; Aoki Junken; Arai Hiroyuki; Iwatsubo Takeshi; Mochita Miyuki; Watanabe Toshio; Satake Masanobu; Ito Yoshiaki; Matsuyama Toshifumi; Mak Tak W; Penninger Josef M; Nishina Hiroshi; Katada Toshiaki
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Developmental biology 2002;250(2):332-47.
2002: Sonoda Hirofumi; Aoki Junken; Hiramatsu Tatsufumi; Ishida Mayuko; Bandoh Koji; Nagai Yuki; Taguchi Ryo; Inoue Keizo; Arai Hiroyuki
A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid.
The Journal of biological chemistry 2002;277(37):34254-63.
2002: Arai Hiroyuki
Platelet-activating factor acetylhydrolase.
Prostaglandins & other lipid mediators 2002;68-69():83-94.
2002: Kaempf-Rotzoll D E; Igarashi K; Aoki J; Jishage K; Suzuki H; Tamai H; Linderkamp O; Arai H
Alpha-tocopherol transfer protein is specifically localized at the implantation site of pregnant mouse uterus.
Biology of reproduction 2002;67(2):599-604.
2002: Hama Kotaro; Bandoh Koji; Kakehi Yoshiyuki; Aoki Junken; Arai Hiroyuki
Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.
FEBS letters 2002;523(1-3):187-92.
2002: Umezu-Goto Makiko; Kishi Yasuhiro; Taira Akitsu; Hama Kotaro; Dohmae Naoshi; Takio Koji; Yamori Takao; Mills Gordon B; Inoue Keizo; Aoki Junken; Arai Hiroyuki
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
The Journal of cell biology 2002;158(2):227-33.
2002: Aoki Junken; Nagai Yuki; Hosono Hiroyuki; Inoue Keizo; Arai Hiroyuki
Structure and function of phosphatidylserine-specific phospholipase A1.
Biochimica et biophysica acta 2002;1582(1-3):26-32.
2002: Arai Hiroyuki; Koizumi Hiroyuki; Aoki Junken; Inoue Keizo
Platelet-activating factor acetylhydrolase (PAF-AH).
Journal of biochemistry 2002;131(5):635-40.
2002: Yun Na-Rae; Yamamoto Masahiro; Arai Hiroyuki; Ishii Masaharu; Igarashi Yasuo
A novel five-subunit-type 2-oxoglutalate:ferredoxin oxidoreductases from Hydrogenobacter thermophilus TK-6.
Biochemical and biophysical research communications 2002;292(1):280-6.
2002: Okamura Nobuyuki; Arai Hiroyuki; Maruyama Masahiro; Higuchi Makoto; Matsui Toshifumi; Tanji Haruko; Seki Takashi; Hirai Hisao; Chiba Hiroshi; Itoh Masatoshi; Sasaki Hidetada
Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease.
The American journal of psychiatry 2002;159(3):474-6.
2001: Maruyama M; Arai H; Sugita M; Tanji H; Higuchi M; Okamura N; Matsui T; Higuchi S; Matsushita S; Yoshida H; Sasaki H
Cerebrospinal fluid amyloid beta(1-42) levels in the mild cognitive impairment stage of Alzheimer's disease.
Experimental neurology 2001;172(2):433-6.
2001: Akiyama T; Gohda J; Shibata S; Nomura Y; Azuma S; Ohmori Y; Sugano S; Arai H; Yamamoto T; Inoue J
Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(11):987-1001.
2001: Hasegawa N; Arai H; Igarashi Y
Two c-type cytochromes, NirM and NirC, encoded in the nir gene cluster of Pseudomonas aeruginosa act as electron donors for nitrite reductase.
Biochemical and biophysical research communications 2001;288(5):1223-30.
2001: Wada H; Nakajoh K; Satoh-Nakagawa T; Suzuki T; Ohrui T; Arai H; Sasaki H
Risk factors of aspiration pneumonia in Alzheimer's disease patients.
Gerontology 2001;47(5):271-6.
2001: Hosono H; Aoki J; Nagai Y; Bandoh K; Ishida M; Taguchi R; Arai H; Inoue K
Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine.
The Journal of biological chemistry 2001;276(32):29664-70.
2001: Yun N R; Arai H; Ishii M; Igarashi Y
The genes for anabolic 2-oxoglutarate: ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6.
Biochemical and biophysical research communications 2001;282(2):589-94.
2001: Ikemoto M; Arai H
[Scavenger receptor family and molecular mechanism of xenobiotic removal]
Seikagaku. The Journal of Japanese Biochemical Society 2001;73(3):161-6.
2001: Yamagata K; Urakami K; Ikeda K; Ji Y; Adachi Y; Arai H; Sasaki H; Sato K; Nakashima K
High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer's disease.
Dementia and geriatric cognitive disorders 2001;12(2):57-62.
2001: Ikemoto M; Arai H
[HDL receptor family]
Nippon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():389-94.
2001: Ishii J; Arai H
[Scavenger receptor expressed by endothelial cells (SREC)]
Nippon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():379-83.
2001: Okamura N; Arai H; Higuchi M; Tashiro M; Matsui T; Hu X S; Takeda A; Itoh M; Sasaki H
[18F]FDG-PET study in dementia with Lewy bodies and Alzheimer's disease.
Progress in neuro-psychopharmacology & biological psychiatry 2001;25(2):447-56.
2001: Shibata N; Arita M; Misaki Y; Dohmae N; Takio K; Ono T; Inoue K; Arai H
Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2244-9.
2001: Yamaya M; Yanai M; Ohrui T; Arai H; Sasaki H
Interventions to prevent pneumonia among older adults.
Journal of the American Geriatrics Society 2001;49(1):85-90.
2000: Okamura N; Shinkawa M; Arai H; Matsui T; Nakajo K; Maruyama M; Hu X S; Sasaki H
[Prediction of progression in patients with mild cognitive impairment using IMP-SPECT]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2000;37(12):974-8.
2000: Hu X S; Okamura N; Arai H; Higuchi M; Matsui T; Tashiro M; Shinkawa M; Itoh M; Ido T; Sasaki H
18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies.
Neurology 2000;55(10):1575-7.
2000: Manabe K; Matsui T; Yamaya M; Sato-Nakagawa T; Okamura N; Arai H; Sasaki H
Sleep patterns and mortality among elderly patients in a geriatric hospital.
Gerontology 2000;46(6):318-22.
2000: Arai H; Ishiguro K; Ohno H; Moriyama M; Itoh N; Okamura N; Matsui T; Morikawa Y; Horikawa E; Kohno H; Sasaki H; Imahori K
CSF phosphorylated tau protein and mild cognitive impairment: a prospective study.
Experimental neurology 2000;166(1):201-3.
2000: Ikeda K; Urakami K; Arai H; Wada K; Wakutani Y; Ji Y; Adachi Y; Okada A; Kowa H; Sasaki H; Ohno K; Ohtsuka Y; Ishikawa Y; Nakashima K
The expression of presenilin 1 mRNA in skin fibroblasts and brains from sporadic Alzheimer's disease.
Dementia and geriatric cognitive disorders 2000;11(5):245-50.
2000: Bae K; Longobardi L; Karasawa K; Malone B; Inoue T; Aoki J; Arai H; Inoue K; Lee T
Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF acetylhydrolases.
The Journal of biological chemistry 2000;275(35):26704-9.
2000: Kitagawa M; Umezu M; Aoki J; Koizumi H; Arai H; Inoue K
Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE.
FEBS letters 2000;479(1-2):57-62.
2000: Ikemoto M; Furuchi T; Arai H; Inoue K
Dual pathways for the secretion of lysosomal cholesterol into a medium from cultured macrophages.
Journal of biochemistry 2000;128(2):251-9.
2000: Iwasaki K; Wang Q; Seki H; Satoh K; Takeda A; Arai H; Sasaki H
The effects of the traditional chinese medicine, "Banxia Houpo Tang (Hange-Koboku To)" on the swallowing reflex in Parkinson's disease.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;7(4):259-63.
2000: Wang Q; Iwasaki K; Suzuki T; Arai H; Ikarashi Y; Yabe T; Toriizuka K; Hanawa T; Yamada H; Sasaki H
Potentiation of brain acetylcholine neurons by Kami-Untan-To (KUT) in aged mice: implications for a possible antidementia drug.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2000;7(4):253-8.
2000: Bandoh K; Aoki J; Taira A; Tsujimoto M; Arai H; Inoue K
Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors.
FEBS letters 2000;478(1-2):159-65.
2000: Ikemoto M; Arai H; Feng D; Tanaka K; Aoki J; Dohmae N; Takio K; Adachi H; Tsujimoto M; Inoue K
Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6538-43.
2000: Higuchi M; Tashiro M; Arai H; Okamura N; Hara S; Higuchi S; Itoh M; Shin R W; Trojanowski J Q; Sasaki H
Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies.
Experimental neurology 2000;162(2):247-56.
2000: Arai H; Suzuki T; Sasaki H; Hanawa T; Toriizuka K; Yamada H
[A new interventional strategy for Alzheimer's disease by Japanese herbal medicine]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2000;37(3):212-5.
2000: Nakagawa T; Sekizawa K; Nakajoh K; Tanji H; Arai H; Sasaki H
Silent cerebral infarction: a potential risk for pneumonia in the elderly.
Journal of internal medicine 2000;247(2):255-9.
2000: Nakajoh K; Nakagawa T; Sekizawa K; Matsui T; Arai H; Sasaki H
Relation between incidence of pneumonia and protective reflexes in post-stroke patients with oral or tube feeding.
Journal of internal medicine 2000;247(1):39-42.
2000: Higuchi M; Yanai K; Okamura N; Meguro K; Arai H; Itoh M; Iwata R; Ido T; Watanabe T; Sasaki H
Histamine H(1) receptors in patients with Alzheimer's disease assessed by positron emission tomography.
Neuroscience 2000;99(4):721-9.
1999: Matsui T; Higuchi M; Okamura N; Arai H; Sasaki H
A practical method to predict rate of cognitive decline in mild to moderate Alzheimer's disease.
Neurology 1999;53(9):2208-9.
1999: Hayashi N R; Arai H; Kodama T; Igarashi Y
The cbbQ genes, located downstream of the form I and form II RubisCO genes, affect the activity of both RubisCOs.
Biochemical and biophysical research communications 1999;265(1):177-83.
1999: Manya H; Aoki J; Kato H; Ishii J; Hino S; Arai H; Inoue K
Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase.
The Journal of biological chemistry 1999;274(45):31827-32.
1999: Arai H
[Molecular mechanism of vitamin E transport in the body]
Nippon rinsho. Japanese journal of clinical medicine 1999;57(10):2276-83.
1999: Okamura N; Arai H; Higuchi M; Tashiro M; Matsui T; Itoh M; Iwatsubo T; Tomita T; Sasaki H
Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans.
Neuroscience letters 1999;273(3):203-7.
1999: Bandoh K; Aoki J; Hosono H; Kobayashi S; Kobayashi T; Murakami-Murofushi K; Tsujimoto M; Arai H; Inoue K
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid.
The Journal of biological chemistry 1999;274(39):27776-85.
1999: Nakajoh K; Satoh-Nakagawa T; Arai H; Yanai M; Yamaya M; Sasaki H
Longevity may decrease medical costs.
Journal of the American Geriatrics Society 1999;47(9):1161-2.
1999: Aikawa K; Sato Y; Furuchi T; Ikemoto M; Fujimoto Y; Arai H; Inoue K
Inhibition of cholesteryl ester formation in macrophages by azole antimycotics.
Biochemical pharmacology 1999;58(3):447-53.
1999: Arita M; Arai H; Inoue K
[Physiological function of alpha-tocopherol transfer protein]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(8 Suppl):1219-26.
1999: Arai H
[PAF acetylhydrolase]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(8 Suppl):1075-83.
1999: Arai H
[Genetic risk factors in senile dementia]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 1999;36(4):251-5.
1999: Nagai Y; Aoki J; Sato T; Amano K; Matsuda Y; Arai H; Inoue K
An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans.
The Journal of biological chemistry 1999;274(16):11053-9.
1999: Isoe-Wada K; Urakami K; Wakutani Y; Adachi Y; Arai H; Sasaki H; Nakashima K
Alteration in brain presenilin-1 mRNA expression in sporadic Alzheimer's disease.
European journal of neurology : the official journal of the European Federation of Neurological Societies 1999;6(2):163-7.
1998: Sasaki H; Sekizawa K; Yanai M; Arai H; Yamaya M; Ohrui T
Effects of air pollution and smoking on chronic obstructive pulmonary disease and bronchial asthma.
The Tohoku journal of experimental medicine 1998;186(3):151-67.
1998: Arai H; Satoh-Nakagawa T; Higuchi M; Morikawa Y; Miura M; Kawakami H; Seki H; Takase S; Sasaki H
No increase in cerebrospinal fluid tau protein levels in patients with vascular dementia.
Neuroscience letters 1998;256(3):174-6.
1998: Hosomi A; Goto K; Kondo H; Iwatsubo T; Yokota T; Ogawa M; Arita M; Aoki J; Arai H; Inoue K
Localization of alpha-tocopherol transfer protein in rat brain.
Neuroscience letters 1998;256(3):159-62.
1998: Arita M; Sato Y; Arai H; Inoue K
Binding of alpha-tocopherylquinone, an oxidized form of alpha-tocopherol, to glutathione-S-transferase in the liver cytosol.
FEBS letters 1998;436(3):424-6.
1998: Hasegawa N; Arai H; Igarashi Y
Activation of a consensus FNR-dependent promoter by DNR of Pseudomonas aeruginosa in response to nitrite.
FEMS microbiology letters 1998;166(2):213-7.
1998: Hayashi N R; Arai H; Kodama T; Igarashi Y
The nirQ gene, which is required for denitrification of Pseudomonas aeruginosa, can activate the RubisCO from Pseudomonas hydrogenothermophila.
Biochimica et biophysica acta 1998;1381(3):347-50.
1998: Manya H; Aoki J; Watanabe M; Adachi T; Asou H; Inoue Y; Arai H; Inoue K
Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain.
The Journal of biological chemistry 1998;273(29):18567-72.
1998: Itabashi S; Arai H; Matsui T; Matsushita S; Muramatsu T; Higuchi S; Trojanowski J Q; Sasaki H
Absence of association of alpha1-antichymotrypsin polymorphisms with Alzheimer's disease: a report on autopsy-confirmed cases.
Experimental neurology 1998;151(2):237-40.
1998: Watanabe M; Aoki J; Manya H; Arai H; Inoue K
Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase.
Biochimica et biophysica acta 1998;1401(1):73-9.
1997: Sasaki H; Sekizawa K; Yanai M; Arai H; Yamaya M; Ohrui T
New strategies for aspiration pneumonia.
Internal medicine (Tokyo, Japan) 1997;36(12):851-5.
1997: Hayashi N R; Arai H; Kodama T; Igarashi Y
The novel genes, cbbQ and cbbO, located downstream from the RubisCO genes of Pseudomonas hydrogenothermophila, affect the conformational states and activity of RubisCO.
Biochemical and biophysical research communications 1997;241(2):565-9.
1997: Matsuzawa A; Hattori K; Aoki J; Arai H; Inoue K
Protection against oxidative stress-induced cell death by intracellular platelet-activating factor-acetylhydrolase II.
The Journal of biological chemistry 1997;272(51):32315-20.
1997: Arita M; Nomura K; Arai H; Inoue K
alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12437-41.
1997: Adachi T; Aoki J; Manya H; Asou H; Arai H; Inoue K
PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells.
Neuroscience letters 1997;235(3):133-6.
1997: Arai H; Terajima M; Miura M; Higuchi S; Muramatsu T; Matsushita S; Machida N; Nakagawa T; Lee V M; Trojanowski J Q; Sasaki H
Effect of genetic risk factors and disease progression on the cerebrospinal fluid tau levels in Alzheimer's disease.
Journal of the American Geriatrics Society 1997;45(10):1228-31.
1997: Higuchi M; Arai H; Nakagawa T; Higuchi S; Muramatsu T; Matsushita S; Kosaka Y; Itoh M; Sasaki H
Regional cerebral glucose utilization is modulated by the dosage of apolipoprotein E type 4 allele and alpha1-antichymotrypsin type A allele in Alzheimer's disease.
Neuroreport 1997;8(12):2639-43.
1997: Hosomi A; Arita M; Sato Y; Kiyose C; Ueda T; Igarashi O; Arai H; Inoue K
Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs.
FEBS letters 1997;409(1):105-8.
1997: Nakagawa T; Sekizawa K; Arai H; Kikuchi R; Manabe K; Sasaki H
High incidence of pneumonia in elderly patients with basal ganglia infarction.
Archives of internal medicine 1997;157(3):321-4.
1997: Sato T; Aoki J; Nagai Y; Dohmae N; Takio K; Doi T; Arai H; Inoue K
Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family.
The Journal of biological chemistry 1997;272(4):2192-8.
1997: Kawasaki S; Arai H; Kodama T; Igarashi Y
Gene cluster for dissimilatory nitrite reductase (nir) from Pseudomonas aeruginosa: sequencing and identification of a locus for heme d1 biosynthesis.
Journal of bacteriology 1997;179(1):235-42.
1997: Arai H; Higuchi S; Sasaki H
Apolipoprotein E genotyping and cerebrospinal fluid tau protein: implications for the clinical diagnosis of Alzheimer's disease.
Gerontology 1997;43 Suppl 1():2-10.
1996: Hattori K; Adachi H; Matsuzawa A; Yamamoto K; Tsujimoto M; Aoki J; Hattori M; Arai H; Inoue K
cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase.
The Journal of biological chemistry 1996;271(51):33032-8.
1996: Arai H; Satoh K; Terajima M; Nakagawa T; Higuchi M; Kosaka Y; Zhu C; Sasaki H
[Tau protein in cerebrospinal fluid--a potential marker of Alzheimer's disease]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 1996;33(9):669-75.
1996: Hattori M; Aoki J; Arai H; Inoue K
PAF and PAF acetylhydrolase in the nervous system.
Journal of lipid mediators and cell signalling 1996;14(1-3):99-102.
1996: Bao F; Arai H; Matsushita S; Higuchi S; Sasaki H
Expression of apolipoprotein E in normal and diverse neurodegenerative disease brain.
Neuroreport 1996;7(11):1733-9.
1996: Arai H
Biological markers for the clinical diagnosis of Alzheimer's disease.
The Tohoku journal of experimental medicine 1996;179(2):65-79.
1996: Arai H; Terajima M; Nakagawa T; Higuchi S; Mochizuki H; Sasaki H
Pupil dilatation assay by tropicamide is modulated by apolipoprotein E epsilon 4 allele dosage in Alzheimer's disease.
Neuroreport 1996;7(4):918-20.
1996: Fukasawa M; Adachi H; Hirota K; Tsujimoto M; Arai H; Inoue K
SRB1, a class B scavenger receptor, recognizes both negatively charged liposomes and apoptotic cells.
Experimental cell research 1996;222(1):246-50.
1995: Kawasaki S; Arai H; Igarashi Y; Kodama T
Sequencing and characterization of the downstream region of the genes encoding nitrite reductase and cytochrome c-551 (nirSM) from Pseudomonas aeruginosa: identification of the gene necessary for biosynthesis of heme d1.
Gene 1995;167(1-2):87-91.
1995: Hattori M; Adachi H; Aoki J; Tsujimoto M; Arai H; Inoue K
Cloning and expression of a cDNA encoding the beta-subunit (30-kDa subunit) of bovine brain platelet-activating factor acetylhydrolase.
The Journal of biological chemistry 1995;270(52):31345-52.
1995: Gotoda T; Arita M; Arai H; Inoue K; Yokota T; Fukuo Y; Yazaki Y; Yamada N
Adult-onset spinocerebellar dysfunction caused by a mutation in the gene for the alpha-tocopherol-transfer protein.
The New England journal of medicine 1995;333(20):1313-8.
1995: Arai H; Terajima M; Miura M; Higuchi S; Muramatsu T; Machida N; Seiki H; Takase S; Clark C M; Lee V M
Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer's disease.
Annals of neurology 1995;38(4):649-52.
1995: Hattori K; Hattori M; Adachi H; Tsujimoto M; Arai H; Inoue K
Purification and characterization of platelet-activating factor acetylhydrolase II from bovine liver cytosol.
The Journal of biological chemistry 1995;270(38):22308-13.
1995: Arai H; Igarashi Y; Kodama T
Expression of the nir and nor genes for denitrification of Pseudomonas aeruginosa requires a novel CRP/FNR-related transcriptional regulator, DNR, in addition to ANR.
FEBS letters 1995;371(1):73-6.
1995: Sato Y; Nishikawa K; Aikawa K; Mimura K; Murakami-Murofushi K; Arai H; Inoue K
Side-chain structure is critical for the transport of sterols from lysosomes to cytoplasm.
Biochimica et biophysica acta 1995;1257(1):38-46.
1995: Arai H; Igarashi Y; Kodama T
The structural genes for nitric oxide reductase from Pseudomonas aeruginosa.
Biochimica et biophysica acta 1995;1261(2):279-84.
1995: Yokoyama K; Hayashi N R; Arai H; Chung S Y; Igarashi Y; Kodama T
Genes encoding RubisCO in Pseudomonas hydrogenothermophila are followed by a novel cbbQ gene similar to nirQ of the denitrification gene cluster from Pseudomonas species.
Gene 1995;153(1):75-9.
1995: Fukasawa M; Hirota K; Adachi H; Mimura K; Murakami-Murofushi K; Tsujimoto M; Arai H; Inoue K
Chinese hamster ovary cells expressing a novel type of acetylated low density lipoprotein receptor. Isolation and characterization.
The Journal of biological chemistry 1995;270(4):1921-7.
1994: Hattori M; Adachi H; Tsujimoto M; Arai H; Inoue K
The catalytic subunit of bovine brain platelet-activating factor acetylhydrolase is a novel type of serine esterase.
The Journal of biological chemistry 1994;269(37):23150-5.
1994: Arai H
[Recent view of intracellular cholesterol transport]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1994;39(9):1518-31.
1994: Hattori M; Adachi H; Tsujimoto M; Arai H; Inoue K
Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]
Nature 1994;370(6486):216-8.
1994: Aikawa K; Furuchi T; Fujimoto Y; Arai H; Inoue K
Structure-specific inhibition of lysosomal cholesterol transport in macrophages by various steroids.
Biochimica et biophysica acta 1994;1213(2):127-34.
1994: Arai H; Igarashi Y; Kodama T
Structure and ANR-dependent transcription of the nir genes for denitrification from Pseudomonas aeruginosa.
Bioscience, biotechnology, and biochemistry 1994;58(7):1286-91.
1993: Furuchi T; Aikawa K; Arai H; Inoue K
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages.
The Journal of biological chemistry 1993;268(36):27345-8.
1993: Hattori M; Arai H; Inoue K
Purification and characterization of bovine brain platelet-activating factor acetylhydrolase.
The Journal of biological chemistry 1993;268(25):18748-53.
1993: Nishikawa K; Sato Y; Arai H; Inoue K
Mobilization of acyl chains from endogenous cellular phospholipids into cholesteryl esters during foam-cell formation in mouse peritoneal macrophages.
Biochimica et biophysica acta 1993;1169(3):257-63.
1993: Sato Y; Arai H; Miyata A; Tokita S; Yamamoto K; Tanabe T; Inoue K
Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein.
The Journal of biological chemistry 1993;268(24):17705-10.
1993: Kikuchi-Yanoshita R; Yanoshita R; Kudo I; Arai H; Takamura T; Nomoto K; Inoue K
Preferential hydrolysis of phosphatidylethanolamine in rat ischemic heart homogenates during in vitro incubation.
Journal of biochemistry 1993;114(1):33-8.
1993: Kinoshita M; Arai H; Fukasawa M; Watanabe T; Tsukamoto K; Hashimoto Y; Inoue K; Kurokawa K; Teramoto T
Apolipoprotein E enhances lipid exchange between lipoproteins mediated by cholesteryl ester transfer protein.
Journal of lipid research 1993;34(2):261-8.
1992: Fukasawa M; Arai H; Inoue K
Establishment of anti-human cholesteryl ester transfer protein monoclonal antibodies and radioimmunoassaying of the level of cholesteryl ester transfer protein in human plasma.
Journal of biochemistry 1992;111(6):696-8.
1991: Sato Y; Hagiwara K; Arai H; Inoue K
Purification and characterization of the alpha-tocopherol transfer protein from rat liver.
FEBS letters 1991;288(1-2):41-5.
1991: Arai H; Igarashi Y; Kodama T
Nitrite activates the transcription of the Pseudomonas aeruginosa nitrite reductase and cytochrome c-551 operon under anaerobic conditions.
FEBS letters 1991;288(1-2):227-8.
1991: Arai H; Igarashi Y; Kodama T
Anaerobically induced expression of the nitrite reductase cytochrome c-551 operon from Pseudomonas aeruginosa.
FEBS letters 1991;280(2):351-3.
1991: Arai H
[Cell damage and phospholipid metabolism in drug-induced oxidative injury]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1991;36(3):453-61.
1990: Nishikawa K; Arai H; Inoue K
Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages.
The Journal of biological chemistry 1990;265(9):5226-31.
1990: Arai H; Sanbongi Y; Igarashi Y; Kodama T
Cloning and sequencing of the gene encoding cytochrome c-551 from Pseudomonas aeruginosa.
FEBS letters 1990;261(1):196-8.
1987: Arai H; Nishikawa K; Inoue K; Nozawa Y; Nojima S
Metabolism of extracellular phospholipids in Tetrahymena pyriformis.
Journal of biochemistry 1987;101(5):1059-67.

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