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Hugo Geerts

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Hugo Geerts; Patrick Roberts; Athan Spiros; Roy Twyman; Larry Alphs; Anthony A Grace
Blinded prospective evaluation of computer-based mechanistic schizophrenia disease model for predicting drug response.
Jo Van Dorpe; Kurt Spittaels; Chris Van den Haute; Ilse Dewachter; Dieder Moechars; Hugo Geerts; Fred Van Leuven
Neuropathobiology in transgenic mice. The case of Alzheimer's disease.
Samir Kumar-Singh; Ann Julliams; Rony Nuydens; Chantal Ceuterick; Christine Labeur; Sally Serneels; Krist'l Vennekens; Peter Van Osta; Hugo Geerts; Bart De Strooper; Christine Van Broeckhoven
In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity.

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All Publications

2012: Hugo Geerts; Patrick Roberts; Athan Spiros; Roy Twyman; Larry Alphs; Anthony A Grace
Blinded prospective evaluation of computer-based mechanistic schizophrenia disease model for predicting drug response.
PloS one 2012;7(12):e49732.
2003: Jo Van Dorpe; Kurt Spittaels; Chris Van den Haute; Ilse Dewachter; Dieder Moechars; Hugo Geerts; Fred Van Leuven
Neuropathobiology in transgenic mice. The case of Alzheimer's disease.
Methods in molecular biology (Clifton, N.J.) 2003;209():333-61.
2002: Samir Kumar-Singh; Ann Julliams; Rony Nuydens; Chantal Ceuterick; Christine Labeur; Sally Serneels; Krist'l Vennekens; Peter Van Osta; Hugo Geerts; Bart De Strooper; Christine Van Broeckhoven
In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity.
Neurobiology of disease 2002;11(2):330-40.
2002: Kelly Tilleman; Chris Van den Haute; Hugo Geerts; Fred Van Leuven; Eddy L Esmans; Luc Moens
Proteomics analysis of the neurodegeneration in the brain of tau transgenic mice.
Proteomics 2002;2(6):656-65.
2002: Rony Nuydens; G van den Kieboom; C Nolten; C Verhulst; Peter Van Osta; Kurt Spittaels; Chris Van den Haute; E De Feyter; Hugo Geerts; Fred Van Leuven
Coexpression of GSK-3beta corrects phenotypic aberrations of dorsal root ganglion cells, cultured from adult transgenic mice overexpressing human protein tau.
Neurobiology of disease 2002;9(1):38-48.
2002: Hugo Geerts; L Finkel; R Carr; A Spiros
Nicotinic receptor modulation: advantages for successful Alzheimer's disease therapy.
Journal of neural transmission. Supplementum 2002;(62):203-16.
2002: Kurt Spittaels; Chris Van den Haute; Jo Van Dorpe; Dick Terwel; K Vandezande; Reena Lasrado; K Bruynseels; Michael C Irizarry; Marleen Verhoye; Johan Van Lint; Jackie R Vandenheede; D Ashton; Marc Mercken; R Loos; Bradley T Hyman; Annemie Van der Linden; Hugo Geerts; Fred Van Leuven
Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice.
Neuroscience 2002;113(4):797-808.
2002: Kelly Tilleman; Ilse Stevens; Kurt Spittaels; Chris Van den Haute; Stefan Clerens; Gert Van den Bergh; Hugo Geerts; Fred Van Leuven; Frans Vandesand; Luc Moens
Differential expression of brain proteins in glycogen synthase kinase-3 transgenic mice: a proteomics point of view.
Proteomics 2002;2(1):94-104.
2001: I Schneider; D Reverse; Ilse Dewachter; Laurence Ris; Nathalie Caluwaerts; Cuno Kuiperi; M Gilis; Hugo Geerts; Hans A Kretzschmar; Emile Godaux; Dieder Moechars; Fred Van Leuven; Jochen Herms
Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation.
The Journal of biological chemistry 2001;276(15):11539-44.
2001: Chris Van den Haute; Kurt Spittaels; Jo Van Dorpe; Reena Lasrado; K Vandezande; I Laenen; Hugo Geerts; Fred Van Leuven
Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.
Neurobiology of disease 2001;8(1):32-44.
2000: Kurt Spittaels; Chris Van den Haute; Jo Van Dorpe; Hugo Geerts; Marc Mercken; K Bruynseels; Reena Lasrado; K Vandezande; I Laenen; T Boon; Johan Van Lint; Jackie R Vandenheede; Dieder Moechars; R Loos; Fred Van Leuven
Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.
The Journal of biological chemistry 2000;275(52):41340-9.
2000: Rony Nuydens; Gerrit D Dispersyn; G van den Kieboom; M de Jong; R Connors; Frans C S Ramaekers; Marcel Borgers; Hugo Geerts
Bcl-2 protects neuronal cells against taxol-induced apoptosis by inducing multi-nucleation.
Apoptosis : an international journal on programmed cell death 2000;5(4):335-43.
2000: Rony Nuydens; Gerrit D Dispersyn; G Van Den Keiboom; M de Jong; R Connors; Frans C S Ramaekers; Marcel Borgers; Hugo Geerts
Bcl-2 protects against apoptosis-related microtubule alterations in neuronal cells.
Apoptosis : an international journal on programmed cell death 2000;5(1):43-51.
2000: Jan-Mark Geusebroek; F Cornelissen; Arnold W M Smeulders; Hugo Geerts
Robust autofocusing in microscopy.
Cytometry 2000;39(1):1-9.
1999: Kurt Spittaels; Chris Van den Haute; Jo Van Dorpe; K Bruynseels; K Vandezande; I Laenen; Hugo Geerts; Marc Mercken; Raf Sciot; Alfons Van Lommel; R Loos; Fred Van Leuven
Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein.
The American journal of pathology 1999;155(6):2153-65.
1999: Stefan Masure; Hugo Geerts; Miroslav Cik; E Hoefnagel; G van den Kieboom; A Tuytelaars; S Harris; Anne Lesage; Josée E Leysen; L Van Der Helm; Peter Verhasselt; Jeff Yon; RD Gordon
Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants.
European journal of biochemistry / FEBS 1999;266(3):892-902.
1999: Gerrit D Dispersyn; Rony Nuydens; Marcel Borgers; Hugo Geerts
Nimodipine and flunarizine have different effects on survival and morphology of PC12 cells during nerve growth factor deprivation.
European journal of pharmacology 1999;384(1):61-70.
1999: Rony Nuydens; J Novalbos; Gerrit D Dispersyn; C Weber; Marcel Borgers; Hugo Geerts
A rapid method for the evaluation of compounds with mitochondria-protective properties.
Journal of neuroscience methods 1999;92(1-2):153-9.
1999: Gerrit D Dispersyn; Rony Nuydens; R Connors; Marcel Borgers; Hugo Geerts
Bcl-2 protects against FCCP-induced apoptosis and mitochondrial membrane potential depolarization in PC12 cells.
Biochimica et biophysica acta 1999;1428(2-3):357-71.
1999: Sebastiaan Engelborghs; M De Brabander; J De Crée; Rudi D'Hooge; Hugo Geerts; H Verhaegen; Peter Paul De Deyn
Unchanged levels of interleukins, neopterin, interferon-gamma and tumor necrosis factor-alpha in cerebrospinal fluid of patients with dementia of the Alzheimer type.
Neurochemistry international 1999;34(6):523-30.
1999: Jan-Mark Geusebroek; Arnold W M Smeulders; F Cornelissen; Hugo Geerts
Segmentation of tissue architecture by distance graph matching.
Cytometry 1999;35(1):11-22.
1998: Bert Schutte; Rony Nuydens; Hugo Geerts; Frans C S Ramaekers
Annexin V binding assay as a tool to measure apoptosis in differentiated neuronal cells.
Journal of neuroscience methods 1998;86(1):63-9.
1998: J Hens; Rony Nuydens; Hugo Geerts; Nicole H M Senden; W J Van de Ven; Anton J M Roebroek; Hilde Van de Velde; Frans C S Ramaekers; Jos L V Broers
Neuronal differentiation is accompanied by NSP-C expression.
Cell and tissue research 1998;292(2):229-37.
1998: Rony Nuydens; M de Jong; G van den Kieboom; C Heers; Gerrit D Dispersyn; F Cornelissen; R Nuyens; Marcel Borgers; Hugo Geerts
Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt.
Journal of neurochemistry 1998;70(3):1124-33.
1998: Gerrit D Dispersyn; Rony Nuydens; M de Jong; Marcel Borgers; Hugo Geerts
Altered [Ca2+] homeostasis in PC12 cells after nerve growth factor deprivation.
Brain research 1998;779(1-2):350-3.
1997: Rony Nuydens; Gerrit D Dispersyn; M de Jong; G van den Kieboom; Marcel Borgers; Hugo Geerts
Aberrant tau phosphorylation and neurite retraction during NGF deprivation in PC12 cells.
Biochemical and biophysical research communications 1997;240(3):687-91.
1996: Hugo Geerts; Rony Nuydens; M de Jong; F Cornelissen; R Nuyens; Luc Wouters
Sabeluzole stabilizes the neuronal cytoskeleton.
Neurobiology of aging 1996;17(4):573-81.
1995: Rony Nuydens; C Heers; A Chadarevian; M de Jong; R Nuyens; F Cornelissen; Hugo Geerts
Sodium butyrate induces aberrant tau phosphorylation and programmed cell death in human neuroblastoma cells.
Brain research 1995;688(1-2):86-94.
1995: Rony Nuydens; M de Jong; R Nuyens; F Cornelissen; Hugo Geerts
Neuronal kinase stimulation leads to aberrant tau phosphorylation and neurotoxicity.
Neurobiology of aging 1995;16(3):465-75; discussion 475-7.
1993: Hans-Georg Olbrich; L V Donck; Hugo Geerts; E Mutschler; G Kober; M Kaltenbach
Cyclosporine increases the intracellular free calcium concentration in electrically paced isolated rat cardiomyocytes.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1993;12(4):652-8.
1993: Rony Nuydens; R Nuyens; F Cornelissen; Hugo Geerts
The fast axonal transport in hippocampal neurones is acutely enhanced by db-cAMP.
Neuroreport 1993;4(2):179-82.
1992: L Ver Donck; G Verellen; Hugo Geerts; Marcel Borgers
Lysophosphatidylcholine-induced Ca(2+)-overload in isolated cardiomyocytes and effect of cytoprotective drugs.
Journal of molecular and cellular cardiology 1992;24(9):977-88.
1992: Hugo Geerts; Rony Nuydens; R Nuyens; F Cornelissen; M De Brabander; P Pauwels; P A Janssen; Y H Song; Eva-Maria Mandelkow
Sabeluzole, a memory-enhancing molecule, increases fast axonal transport in neuronal cell cultures.
Experimental neurology 1992;117(1):36-43.
1991: Hugo Geerts; M de Brabander; Rony Nuydens
Nanovid microscopy.
Nature 1991;351(6329):765-6.
1991: Hans-Georg Olbrich; Hugo Geerts; U Waldmann; E Mutschler; L Ver Donck; G Kober; M Kaltenbach
The effect of cyclosporine on electrically paced isolated rat cardiomyocytes.
Transplantation 1991;51(5):972-6.
1991: M de Brabander; Rony Nuydens; A Ishihara; B Holifield; Ken Jacobson; Hugo Geerts
Lateral diffusion and retrograde movements of individual cell surface components on single motile cells observed with Nanovid microscopy.
The Journal of cell biology 1991;112(1):111-24.
1990: F Cornelissen; R Nuyens; Rony Nuydens; Hugo Geerts
Automatic quantification of fast axonal transport in neuronal cell cultures.
Journal of neuroscience methods 1990;35(1):79-88.
1989: Hugo Geerts; Rony Nuydens; R Nuyens; L Ver Donck
The effect of flunarizine on intracellular calcium in isolated rat cardiomyocytes. A digital image processing study.
Cardiovascular research 1989;23(9):797-806.
1989: M De Brabander; Hugo Geerts; Rony Nuydens; R Nuyens
Detection of gold probes with video-enhanced contrast microscopy: nanovid microscopy.
The American journal of anatomy 1989;185(2-3):282-95.
1988: M De Brabander; Rony Nuydens; Hugo Geerts; C R Hopkins
Dynamic behavior of the transferrin receptor followed in living epidermoid carcinoma (A431) cells with nanovid microscopy.
Cell motility and the cytoskeleton 1988;9(1):30-47.
1987: Hugo Geerts; M De Brabander; Rony Nuydens; S Geuens; M Moeremans; J De Mey; P Hollenbeck
Nanovid tracking: a new automatic method for the study of mobility in living cells based on colloidal gold and video microscopy.
Biophysical journal 1987;52(5):775-82.