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Brian Geisbrecht

Research Profile

Chemicals & Drugs

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Hyperlysinemias

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Shyamal P Choudhari; Brian V Geisbrecht; Jamie C Greenwood; Sangeeta B Joshi; Ryan Kramer; C Russell Middaugh; William D Picking; Michael L Barta; Wendy L Picking
Studies of the conformational stability of invasion plasmid antigen B from Shigella.
Brandon L Garcia; John H Laity; John D Lambris; Zhuoer Lin; Kasra X Ramyar; Daniel Ricklin; Brady J Summers; Apostolia Tzekou; Brian V Geisbrecht
A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins.
Michael L Barta; William J McWhorter; Henry M Miziorko; Brian V Geisbrecht
Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.

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All Publications

2013: Shyamal P Choudhari; Brian V Geisbrecht; Jamie C Greenwood; Sangeeta B Joshi; Ryan Kramer; C Russell Middaugh; William D Picking; Michael L Barta; Wendy L Picking
Studies of the conformational stability of invasion plasmid antigen B from Shigella.
Protein science : a publication of the Protein Society 2013;22(5):666-70.
2013: Brandon L Garcia; John H Laity; John D Lambris; Zhuoer Lin; Kasra X Ramyar; Daniel Ricklin; Brady J Summers; Apostolia Tzekou; Brian V Geisbrecht
A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins.
The Journal of biological chemistry 2013;288(4):2870-81.
2012: Michael L Barta; William J McWhorter; Henry M Miziorko; Brian V Geisbrecht
Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
Biochemistry 2012;51(28):5611-21.
2012: John P Bannantine; Brandon L Garcia; Vivek Kapur; Cari K Lingle; Alex J Raeber; Kasra X Ramyar; Pascal Schacher; Judith R Stabel; Brian V Geisbrecht
MAP1272c encodes an NlpC/P60 protein, an antigen detected in cattle with Johne's disease.
Clinical and vaccine immunology : CVI 2012;19(7):1083-92.
2012: D Andrew Skaff; Kasra X Ramyar; Michael L Barta; Brian V Geisbrecht; William J McWhorter; Henry M Miziorko
Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.
Biochemistry 2012;51(23):4713-22.
2012: Philip R Adam; Michael Barta; Shyamal Choudhari; Nicholas E Dickenson; Brian V Geisbrecht; Mrinalini K Patil; Wendy L Picking; William D Picking
Binding affects the tertiary and quaternary structures of the Shigella translocator protein IpaB and its chaperone IpgC.
Biochemistry 2012;51(19):4062-71.
2012: Michael L Barta; Nicholas E Dickenson; Andrew Keightley; Mrinalini Patil; William D Picking; Wendy L Picking; Gerald J Wyckoff; Brian V Geisbrecht
The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins.
Journal of molecular biology 2012;417(5):395-405.
2012: Michael L Barta; Nicholas E Dickenson; Brian V Geisbrecht; Manita Guragain; Mrinalini Patil; Philip Adam; Wendy L Picking; William D Picking
Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure.
Proteins 2012;80(3):935-45.
2012: Samuel Bouyain; Brian V Geisbrecht
Host glycan recognition by a pore forming toxin.
Structure (London, England : 1993) 2012;20(2):197-8.
2012: Brandon L Garcia; John D Lambris; Kasra X Ramyar; Daniel Ricklin; Brian V Geisbrecht
Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins.
Advances in experimental medicine and biology 2012;946():113-33.
2011: Michael L Barta; Timothy John Herdendorf; William J McWhorter; Henry M Miziorko; D Andrew Skaff; Brian V Geisbrecht
Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis.
The Journal of biological chemistry 2011;286(27):23900-10.
2011: Zvjezdana Sever-Chroneos; Agnieszka Krupa; Jeremy Davis; Misbah Hasan; Ching-Hui Yang; Jacek Szeliga; Mathias Herrmann; Muzafar Hussain; Brian V Geisbrecht; Lester Kobzik; Zissis C Chroneos
Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A.
The Journal of biological chemistry 2011;286(6):4854-70.
2010: H Chen; Daniel Ricklin; Michal Hammel; Brandon L Garcia; William J McWhorter; Georgia Sfyroera; You-Qiang Wu; Apostolia Tzekou; Sheng Li; Brian V Geisbrecht; Virgil L Woods; John D Lambris
Allosteric inhibition of complement function by a staphylococcal immune evasion protein.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17621-6.
2010: Brandon L Garcia; Kasra X Ramyar; Apostolia Tzekou; Daniel Ricklin; William J McWhorter; John D Lambris; Brian V Geisbrecht
Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b.
Journal of molecular biology 2010;402(1):17-29.
2010: John P Bannantine; Judith R Stabel; Darrell O Bayles; Brian V Geisbrecht
Characteristics of an extensive Mycobacterium avium subspecies paratuberculosis recombinant protein set.
Protein expression and purification 2010;72(2):223-33.
2010: Ilse Jongerius; Brandon L Garcia; Brian V Geisbrecht; Jos A G van Strijp; Suzan H M Rooijakkers
Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein.
The Journal of biological chemistry 2010;285(20):14973-9.
2010: Nurit Haspel; Brian V Geisbrecht; John D Lambris; Lydia E Kavraki
Multi-scale characterization of the energy landscape of proteins with application to the C3D/Efb-C complex.
Proteins 2010;78(4):1004-14.
2010: Michael L Barta; Lingling Zhang; Wendy L Picking; Brian V Geisbrecht
Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone.
BMC structural biology 2010;10():21.
2009: Daniel Ricklin; Apostolia Tzekou; Brandon L Garcia; Michal Hammel; William J McWhorter; Georgia Sfyroera; You-Qiang Wu; V Michael Holers; Andrew Herbert; Paul N Barlow; Brian V Geisbrecht; John D Lambris
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2565-74.
2009: Brandon L Garcia; Apostolia Tzekou; Kasra X Ramyar; William J McWhorter; Daniel Ricklin; John D Lambris; Brian V Geisbrecht
Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN).
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 5):482-5.
2008: Daniel Ricklin; Salome K Ricklin-Lichtsteiner; Maciej Markiewski; Brian V Geisbrecht; John D Lambris
Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7463-7.
2008: Nurit Haspel; Daniel Ricklin; Brian V Geisbrecht; Lydia E Kavraki; John D Lambris
Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d.
Protein science : a publication of the Protein Society 2008;17(11):1894-906.
2008: John D Lambris; Daniel Ricklin; Brian V Geisbrecht
Complement evasion by human pathogens.
Nature reviews. Microbiology 2008;6(2):132-42.
2008: Brian V Geisbrecht
Staphylococcal complement inhibitors: biological functions, recognition of complement components, and potential therapeutic implications.
Advances in experimental medicine and biology 2008;632():221-36.
2008: Hui Chen; Michael C Schuster; Georgia Sfyroera; Brian V Geisbrecht; John D Lambris
Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry.
Journal of the American Society for Mass Spectrometry 2008;19(1):55-65.
2007: Michal Hammel; Daniel Nemecek; J Andrew Keightley; George Thomas; Brian V Geisbrecht
The Staphylococcus aureus extracellular adherence protein (Eap) adopts an elongated but structured conformation in solution.
Protein science : a publication of the Protein Society 2007;16(12):2605-17.
2007: Michal Hammel; Georgia Sfyroera; Serapion Pyrpassopoulos; Daniel Ricklin; Kasra X Ramyar; Mihai Pop; Zhongmin Jin; John D Lambris; Brian V Geisbrecht
Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus.
The Journal of biological chemistry 2007;282(41):30051-61.
2007: Michal Hammel; Georgia Sfyroera; Daniel Ricklin; Paola Magotti; John D Lambris; Brian V Geisbrecht
A structural basis for complement inhibition by Staphylococcus aureus.
Nature immunology 2007;8(4):430-7.
2007: Zhonghua Wang; Belinda M Potter; Amanda M Gray; Katherine A Sacksteder; Brian V Geisbrecht; John H Laity
The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a new family of beta-grasp proteins.
Journal of molecular biology 2007;366(2):375-81.
2006: Jason S McLellan; Shenqin Yao; Xiaoyan Zheng; Brian V Geisbrecht; Rodolfo Ghirlando; Philip A Beachy; Daniel J Leahy
Structure of a heparin-dependent complex of Hedgehog and Ihog.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17208-13.
2006: Changping Xie; Pilar Alcaide; Brian V Geisbrecht; Darius Schneider; Mathias Herrmann; Klaus T Preissner; Francis W Luscinskas; Triantafyllos Chavakis
Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus.
The Journal of experimental medicine 2006;203(4):985-94.
2006: Michal Hammel; Kasra X Ramyar; Charles T Spencer; Brian V Geisbrecht
Crystallization and X-ray diffraction analysis of the complement component-3 (C3) inhibitory domain of Efb from Staphylococcus aureus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):285-8.
2006: Brian V Geisbrecht; Samuel Bouyain; Mihai Pop
An optimized system for expression and purification of secreted bacterial proteins.
Protein expression and purification 2006;46(1):23-32.
2006: Brian V Geisbrecht; Boris Nikonenko; Rowena Samala; Reiko Nakamura; Carol A Nacy; Katherine A Sacksteder
Design and optimization of a recombinant system for large-scale production of the MPT64 antigen from Mycobacterium tuberculosis.
Protein expression and purification 2006;46(1):64-72.
2005: Jessica M Danahy; Belinda M Potter; Brian V Geisbrecht; John H Laity
NMR assignment of protein Rv1980c from Mycobacterium tuberculosis.
Journal of biomolecular NMR 2005;33(1):73.
2005: Brian V Geisbrecht; Brent Y Hamaoka; Benjamin Perman; Adam Zemla; Daniel J Leahy
The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens.
The Journal of biological chemistry 2005;280(17):17243-50.
2005: Doug Bassett; James C Morrell; Gregory J Gatto; Jianwu Bai; Brian V Geisbrecht; Philip Hieter; Stephen J Gould
Detecting patterns of protein distribution and gene expression in silico.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):516.
2004: Brent Y Hamaoka; Charles E Dann; Brian V Geisbrecht; Daniel J Leahy
Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11673-8.
2003: Brian V Geisbrecht; Kimberly A Dowd; Ronald W Barfield; Patti A Longo; Daniel J Leahy
Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin.
The Journal of biological chemistry 2003;278(35):32561-8.
2003: Gregory J Gatto; Ernest L Maynard; Anthony L Guerrerio; Brian V Geisbrecht; Stephen J Gould; Jeremy Berg
Correlating structure and affinity for PEX5:PTS1 complexes.
Biochemistry 2003;42(6):1660-6.
2002: Dongyan Zhang; Wenfeng Yu; Brian V Geisbrecht; Stephen J Gould; Howard Sprecher; Horst Schulz
Functional characterization of Delta3,Delta2-enoyl-CoA isomerases from rat liver.
The Journal of biological chemistry 2002;277(11):9127-32.
2000: Gregory J Gatto; Brian V Geisbrecht; Stephen J Gould; Jeremy Berg
Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5.
Nature structural biology 2000;7(12):1091-5.
2000: Katherine A Sacksteder; B J Biery; James C Morrell; Barbara K Goodman; Brian V Geisbrecht; R P Cox; Stephen J Gould; Michael T Geraghty
Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia.
American journal of human genetics 2000;66(6):1736-43.
2000: Gregory J Gatto; Brian V Geisbrecht; Stephen J Gould; Jeremy Berg
A proposed model for the PEX5-peroxisomal targeting signal-1 recognition complex.
Proteins 2000;38(3):241-6.
1999: Brian V Geisbrecht; Stephen J Gould
The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase.
The Journal of biological chemistry 1999;274(43):30527-33.
1999: Brian V Geisbrecht; X Liang; James C Morrell; H Schulz; Stephen J Gould
The mouse gene PDCR encodes a peroxisomal delta(2), delta(4)-dienoyl-CoA reductase.
The Journal of biological chemistry 1999;274(36):25814-20.
1999: Brian V Geisbrecht; Dianzheng Zhang; H Schulz; Stephen J Gould
Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes.
The Journal of biological chemistry 1999;274(31):21797-803.
1999: Brian V Geisbrecht; K Schulz; K Nau; Michael T Geraghty; H Schulz; Ralf Erdmann; Stephen J Gould
Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism.
Biochemical and biophysical research communications 1999;260(1):28-34.
1999: Michael T Geraghty; D Bassett; James C Morrell; Gregory J Gatto; Jianwu Bai; Brian V Geisbrecht; Philip Hieter; Stephen J Gould
Detecting patterns of protein distribution and gene expression in silico.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2937-42.
1998: Brian V Geisbrecht; D Zhu; K Schulz; K Nau; James C Morrell; Michael T Geraghty; H Schulz; Ralf Erdmann; Stephen J Gould
Molecular characterization of Saccharomyces cerevisiae Delta3, Delta2-enoyl-CoA isomerase.
The Journal of biological chemistry 1998;273(50):33184-91.
1998: Brian V Geisbrecht; Cynthia S Collins; BE Reuber; Stephen J Gould
Disruption of a PEX1-PEX6 interaction is the most common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8630-5.