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Gerd Geisslinger

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
75
Lötsch, Jörn
74
Brune, Kay
63
Tegeder, Irmgard
32
Schmidt, Helmut
28
Skarke, Carsten
28
Niederberger, Ellen
26
Grösch, Sabine
21
Schmidtko, Achim
15
Scholich, Klaus
14
Kobal, Gerd
14
Coste, Ovidiu
12
Maier, Thorsten
12
Schmidt, Ronald
11
Bräutigam, Lutz
9
Schiffmann, Susanne

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Publications

TOP 3
Farnik Harald; El-Duweik Juliane; Welsch Christoph; Sarrazin Christoph; Lötsch Jörn; Zeuzem Stefan; Geisslinger Gerd; Schmidt Helmut
Highly sensitive determination of HCV protease inhibitors boceprevir (SCH 503034) and telaprevir (VX 950) in human plasma by LC-MS/MS.
Doehring Alexandra; Freynhagen Rainer; Griessinger Norbert; Zimmermann Michael; Sittl Reinhard; Hentig Nils von; Geisslinger Gerd; Lötsch Jörn
Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.
Weigert Andreas; Schiffmann Susanne; Sekar Divya; Ley Stephanie; Menrad Heidi; Werno Christian; Grosch Sabine; Geisslinger Gerd; Brüne Bernhard
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.

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All Publications

2009: Farnik Harald; El-Duweik Juliane; Welsch Christoph; Sarrazin Christoph; Lötsch Jörn; Zeuzem Stefan; Geisslinger Gerd; Schmidt Helmut
Highly sensitive determination of HCV protease inhibitors boceprevir (SCH 503034) and telaprevir (VX 950) in human plasma by LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(31):4001-6.
2009: Doehring Alexandra; Freynhagen Rainer; Griessinger Norbert; Zimmermann Michael; Sittl Reinhard; Hentig Nils von; Geisslinger Gerd; Lötsch Jörn
Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.
The Clinical journal of pain 2009;25(9):781-5.
2009: Weigert Andreas; Schiffmann Susanne; Sekar Divya; Ley Stephanie; Menrad Heidi; Werno Christian; Grosch Sabine; Geisslinger Gerd; Brüne Bernhard
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
International journal of cancer. Journal international du cancer 2009;125(9):2114-21.
2009: Lötsch Jörn; Geisslinger Gerd; Tegeder Irmgard
Genetic modulation of the pharmacological treatment of pain.
Pharmacology & therapeutics 2009;124(2):168-84.
2009: Bockhart Vanessa; Constantin Cristina Elena; Häussler Annett; Wijnvoord Nina; Kanngiesser Maike; Myrczek Thekla; Pickert Geethanjali; Popp Laura; Sobotzik Jürgen-Markus; Pasparakis Manolis; Kuner Rohini; Geisslinger Gerd; Schultz Christian; Kress Michaela; Tegeder Irmgard
Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(41):12919-29.
2009: Linke Bona; Pierre Sandra; Coste Ovidiu; Angioni Carlo; Becker Wiebke; Maier Thorsten Jürgen; Steinhilber Dieter; Wittpoth Claus; Geisslinger Gerd; Scholich Klaus
Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing.
Journal of proteome research 2009;8(10):4851-9.
2009: Maier Thorsten J; Schiffmann Susanne; Wobst Ivonne; Birod Kerstin; Angioni Carlo; Hoffmann Marika; Lopez Jakob J; Glaubitz Clemens; Steinhilber Dieter; Geisslinger Gerd; Grösch Sabine
Cellular membranes function as a storage compartment for celecoxib.
Journal of molecular medicine (Berlin, Germany) 2009;87(10):981-93.
2009: Tausch Lars; Henkel Arne; Siemoneit Ulf; Poeckel Daniel; Kather Nicole; Franke Lutz; Hofmann Bettina; Schneider Gisbert; Angioni Carlo; Geisslinger Gerd; Skarke Carsten; Holtmeier Wolfgang; Beckhaus Tobias; Karas Michael; Jauch Johann; Werz Oliver
Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3433-42.
2009: Popp Laura; Häussler Annett; Olliges Anke; Nüsing Rolf; Narumiya Shuh; Geisslinger Gerd; Tegeder Irmgard
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.
European journal of pain (London, England) 2009;13(7):691-703.
2009: Lötsch Jörn; Rohrbacher Maren; Schmidt Helmut; Doehring Alexandra; Brockmöller Jürgen; Geisslinger Gerd
Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?
Pain 2009;144(1-2):119-24.
2009: Gao W; Schmidtko A; Wobst I; Lu R; Angioni C; Geisslinger G
Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2009;60(2):145-50.
2009: Lötsch Jörn; von Hentig Nils; Freynhagen Rainer; Griessinger Norbert; Zimmermann Michael; Doehring Alexandra; Rohrbacher Maren; Sittl Reinhard; Geisslinger Gerd
Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers.
Pharmacogenetics and genomics 2009;19(6):429-36.
2009: Schmidtko Achim; Tegeder Irmgard; Geisslinger Gerd
No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing.
Trends in neurosciences 2009;32(6):339-46.
2009: Doehring Alexandra; Hentig Nils von; Graff Jochen; Salamat Syavash; Schmidt Michael; Geisslinger Gerd; Harder Sebastian; Lötsch Jörn
Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution.
Pharmacogenetics and genomics 2009;19(6):407-14.
2009: Schiffmann Susanne; Sandner Jessica; Birod Kerstin; Wobst Ivonne; Angioni Carlo; Ruckhäberle Eugen; Kaufmann Manfred; Ackermann Hanns; Lötsch Jörn; Schmidt Helmut; Geisslinger Gerd; Grösch Sabine
Ceramide synthases and ceramide levels are increased in breast cancer tissue.
Carcinogenesis 2009;30(5):745-52.
2009: Randriamboavonjy Voahanginirina; Badenhoop Klaus; Schmidt Helmut; Geisslinger Gerd; Fisslthaler Beate; Fleming Ingrid
The S1P(2) receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes.
Basic research in cardiology 2009;104(3):333-40.
2009: Pierre Sandra; Eschenhagen Thomas; Geisslinger Gerd; Scholich Klaus
Capturing adenylyl cyclases as potential drug targets.
Nature reviews. Drug discovery 2009;8(4):321-35.
2009: Gao Wei; Schmidtko Achim; Lu Ruirui; Brenneis Christian; Angioni Carlo; Schmidt Ronald; Geisslinger Gerd
Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2).
European journal of pharmacology 2009;608(1-3):28-31.
2009: Grisk Olaf; Steinbach Antje C; Ciecholewski Sabine; Schlüter Torsten; Klöting Ingrid; Schmidt Helmut; Dazert Eike; Schaeffeler Elke; Steil Leif; Gauer Stefan; Jedlitschky Gabriele; Schwab Matthias; Geisslinger Gerd; Hauser Ingeborg A; Völker Uwe; Kroemer Heyo K; Rettig Rainer
Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function.
Pharmacogenetics and genomics 2009;19(4):276-88.
2009: Oertel Bruno Georg; Kettner Mattias; Scholich Klaus; Renné Christoph; Roskam Bianca; Geisslinger Gerd; Schmidt Peter Harald; Lötsch Jörn
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.
The Journal of biological chemistry 2009;284(10):6530-5.
2009: Revermann Marc; Barbosa-Sicard Eduardo; Dony Eva; Schermuly Ralph T; Morisseau Christophe; Geisslinger Gerd; Fleming Ingrid; Hammock Bruce D; Brandes Ralf P
Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.
Journal of hypertension 2009;27(2):322-31.
2008: Pierre Sandra; Maeurer Christian; Coste Ovidiu; Becker Wiebke; Schmidtko Achim; Holland Sabrina; Wittpoth Claus; Geisslinger Gerd; Scholich Klaus
Toponomics analysis of functional interactions of the ubiquitin ligase PAM (Protein Associated with Myc) during spinal nociceptive processing.
Molecular & cellular proteomics : MCP 2008;7(12):2475-85.
2008: Coste Ovidiu; Brenneis Christian; Linke Bona; Pierre Sandra; Maeurer Christian; Becker Wiebke; Schmidt Helmut; Gao Wei; Geisslinger Gerd; Scholich Klaus
Sphingosine 1-phosphate modulates spinal nociceptive processing.
The Journal of biological chemistry 2008;283(47):32442-51.
2008: Tegeder Irmgard; Adolph Jan; Schmidt Helmut; Woolf Clifford J; Geisslinger Gerd; Lötsch Jörn
Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.
European journal of pain (London, England) 2008;12(8):1069-77.
2008: Ruckhäberle Eugen; Rody Achim; Engels Knut; Gaetje Regine; von Minckwitz Gunter; Schiffmann Susanne; Grösch Sabine; Geisslinger Gerd; Holtrich Uwe; Karn Thomas; Kaufmann Manfred
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Breast cancer research and treatment 2008;112(1):41-52.
2008: Schmidtko Achim; Luo Ceng; Gao Wei; Geisslinger Gerd; Kuner Rohini; Tegeder Irmgard
Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn.
Pain 2008;139(3):632-43.
2008: Maier Thorsten J; Tausch Lars; Hoernig Michael; Coste Ovidiu; Schmidt Ronald; Angioni Carlo; Metzner Julia; Groesch Sabine; Pergola Carlo; Steinhilber Dieter; Werz Oliver; Geisslinger Gerd
Celecoxib inhibits 5-lipoxygenase.
Biochemical pharmacology 2008;76(7):862-72.
2008: Schiefelbein Dana; Seitz Oliver; Goren Itamar; Dissmann Jan Philipp; Schmidt Helmut; Bachmann Malte; Sader Robert; Geisslinger Gerd; Pfeilschifter Josef; Frank Stefan
Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair.
Molecular pharmacology 2008;74(4):952-63.
2008: Niederberger Ellen; Geisslinger Gerd
The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3432-42.
2008: Schmidtko Achim; Gao Wei; König Peter; Heine Sandra; Motterlini Roberto; Ruth Peter; Schlossmann Jens; Koesling Doris; Niederberger Ellen; Tegeder Irmgard; Friebe Andreas; Geisslinger Gerd
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(34):8568-76.
2008: Schiffmann Susanne; Maier Thorsten Jürgen; Wobst Ivonne; Janssen Astrid; Corban-Wilhelm Heike; Angioni Carlo; Geisslinger Gerd; Grösch Sabine
The anti-proliferative potency of celecoxib is not a class effect of coxibs.
Biochemical pharmacology 2008;76(2):179-87.
2008: Wobst Ivonne; Schiffmann Susanne; Birod Kerstin; Maier Thorsten J; Schmidt Ronald; Angioni Carlo; Geisslinger Gerd; Grösch Sabine
Dimethylcelecoxib inhibits prostaglandin E2 production.
Biochemical pharmacology 2008;76(1):62-9.
2008: Coste Ovidiu; Pierre Sandra; Marian Claudiu; Brenneis Christian; Angioni Carlo; Schmidt Helmut; Popp Laura; Geisslinger Gerd; Scholich Klaus
Antinociceptive activity of the S1P-receptor agonist FTY720.
Journal of cellular and molecular medicine 2008;12(3):995-1004.
2008: Weber Michael; Burian Maria; Dragutinovic Ivana; Moellmann Helge; Nef Holger; Elsaesser Albrecht; Mitrovic Veselin; Hamm Christian; Geisslinger Gerd
Genetic polymorphism of the type A human natriuretic peptide receptor (NPR-A) gene contributes to the interindividual variability in the BNP system.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2008;10(5):482-9.
2008: Schiefelbein Dana; Goren Itamar; Fisslthaler Beate; Schmidt Helmut; Geisslinger Gerd; Pfeilschifter Josef; Frank Stefan
Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses.
The Journal of biological chemistry 2008;283(22):15479-90.
2008: Brenneis Christian; Coste Ovidiu; Schmidt Ronald; Angioni Carlo; Popp Laura; Nusing Rolf M; Becker Wiebke; Scholich Klaus; Geisslinger Gerd
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice.
Journal of cellular and molecular medicine 2008;12(2):639-48.
2008: Degousee Norbert; Fazel Shafie; Angoulvant Denis; Stefanski Eva; Pawelzik Sven-Christian; Korotkova Marina; Arab Sara; Liu Peter; Lindsay Thomas F; Zhuo Sun; Butany Jagdish; Li Ren-Ke; Audoly Laurent; Schmidt Ronald; Angioni Carlo; Geisslinger Gerd; Jakobsson Per-Johan; Rubin Barry B
Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.
Circulation 2008;117(13):1701-10.
2008: Oertel B G; Preibisch C; Wallenhorst T; Hummel T; Geisslinger G; Lanfermann H; Lötsch J
Differential opioid action on sensory and affective cerebral pain processing.
Clinical pharmacology and therapeutics 2008;83(4):577-88.
2008: Schmidtko Achim; Gao Wei; Sausbier Matthias; Rauhmeier Inga; Sausbier Ulrike; Niederberger Ellen; Scholich Klaus; Huber Andrea; Neuhuber Winfried; Allescher Hans-Dieter; Hofmann Franz; Tegeder Irmgard; Ruth Peter; Geisslinger Gerd
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(6):1320-30.
2008: Niederberger Ellen; Geisslinger Gerd
Proteomics in neuropathic pain research.
Anesthesiology 2008;108(2):314-23.
2008: Janssen Astrid; Schiffmann Susanne; Birod Kerstin; Maier Thorsten J; Wobst Ivonne; Geisslinger Gerd; Grösch Sabine
p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells.
Biochemical and biophysical research communications 2008;365(4):698-703.
2007: Skarke Carsten; Schuss Patrick; Kirchhof Anja; Doehring Alexandra; Geisslinger Gerd; Lötsch Jörn
Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.
Pharmacogenomics 2007;8(12):1643-60.
2007: Graff J; Skarke C; Klinkhardt U; Watzer B; Harder S; Seyberth H; Geisslinger G; Nüsing R M
Effects of selective COX-2 inhibition on prostanoids and platelet physiology in young healthy volunteers.
Journal of thrombosis and haemostasis : JTH 2007;5(12):2376-85.
2007: Doehring Alexandra; Geisslinger Gerd; Lötsch Jörn
Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing.
Prostaglandins & other lipid mediators 2007;84(3-4):128-37.
2007: Lötsch Jörn; Geisslinger Gerd
Current evidence for a modulation of nociception by human genetic polymorphisms.
Pain 2007;132(1-2):18-22.
2007: Niederberger Ellen; Ehnert Corina; Gao Wei; Coste Ovidiu; Schmidtko Achim; Popp Laura; Gall Charlotte von; Korf Horst Werner; Tegeder Irmgard; Geisslinger Gerd
The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.
Biochemical and biophysical research communications 2007;362(1):75-80.
2007: Weigert Andreas; Tzieply Nico; von Knethen Andreas; Johann Axel M; Schmidt Helmut; Geisslinger Gerd; Brüne Bernhard
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.
Molecular biology of the cell 2007;18(10):3810-9.
2007: Lötsch Jörn; Harder Sebastian; Stürmer Martin; Doerr Hans-Wilhelm; Geisslinger Gerd; Staszewski Schlomo; von Hentig Nils
Association of saquinavir plasma concentrations with side effects but not with antiretroviral outcome in patients infected with protease inhibitor-susceptible human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 2007;51(9):3264-72.
2007: Daniel Carolin; Sartory Nico A; Zahn Nadine; Schmidt Ronald; Geisslinger Gerd; Radeke Heinfried H; Stein Jurgen M
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Molecular immunology 2007;44(13):3305-16.
2007: Schuligoi Rufina; Schmidt Ronald; Geisslinger Gerd; Kollroser Manfred; Peskar Bernhard A; Heinemann Akos
PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors.
Biochemical pharmacology 2007;74(1):107-17.
2007: Pierre S C; Schmidt R; Brenneis C; Michaelis M; Geisslinger G; Scholich K
Inhibition of cyclooxygenases by dipyrone.
British journal of pharmacology 2007;151(4):494-503.
2007: Lötsch Jörn; Belfer Inna; Kirchhof Anja; Mishra Bikash K; Max Mitchell B; Doehring Alexandra; Costigan Michael; Woolf Clifford J; Geisslinger Gerd; Tegeder Irmgard
Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.
Clinical chemistry 2007;53(6):1010-5.
2007: Metzner Julia; Popp Laura; Marian Claudiu; Schmidt Ronald; Manderscheid Christine; Renne Christoph; Fisslthaler Beate; Fleming Ingrid; Busse Rudi; Geisslinger Gerd; Niederberger Ellen
The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE-/- mice.
Journal of molecular medicine (Berlin, Germany) 2007;85(6):623-33.
2007: Graff Jochen; Arabmotlagh Mohammed; Cheung Raymond; Geisslinger Gerd; Harder Sebastian
Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study.
Clinical therapeutics 2007;29(3):438-47.
2007: Niederberger Ellen; Schmidtko Achim; Gao Wei; Kühlein Hilmar; Ehnert Corina; Geisslinger Gerd
Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB.
European journal of pharmacology 2007;559(1):55-60.
2007: Daniel Carolin; Sartory Nico; Zahn Nadine; Geisslinger Gerd; Radeke Heinfried H; Stein Juergen M
FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2458-68.
2007: Schmidtko Achim; Burian Maria; Altis Kosta; Hardt Katja; Angioni Carlo; Schmidt Ronald; Podda Maurizio; Geisslinger Gerd
Pharmacological and histopathological characterization of a hyperalgesia model induced by freeze lesion.
Pain 2007;127(3):287-95.
2007: Oertel B G; Schneider A; Rohrbacher M; Schmidt H; Tegeder I; Geisslinger G; Lötsch J
The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans.
Clinical pharmacology and therapeutics 2007;81(1):59-68.
2006: Skarke Carsten; Reus Maximilian; Schmidt Ronald; Grundei Inga; Schuss Patrick; Geisslinger Gerd; Lötsch Jörn
The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production.
Clinical pharmacology and therapeutics 2006;80(6):621-32.
2006: Schmidt Helmut; Schmidt Ronald; Geisslinger Gerd
LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples.
Prostaglandins & other lipid mediators 2006;81(3-4):162-70.
2006: Tegeder Irmgard; Costigan Michael; Griffin Robert S; Abele Andrea; Belfer Inna; Schmidt Helmut; Ehnert Corina; Nejim Jemiel; Marian Claudiu; Scholz Joachim; Wu Tianxia; Allchorne Andrew; Diatchenko Luda; Binshtok Alexander M; Goldman David; Adolph Jan; Sama Swetha; Atlas Steven J; Carlezon William A; Parsegian Aram; Lötsch Jörn; Fillingim Roger B; Maixner William; Geisslinger Gerd; Max Mitchell B; Woolf Clifford J
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.
Nature medicine 2006;12(11):1269-77.
2006: Rohrbacher Maren; Kirchhof Anja; Geisslinger Gerd; Lötsch Jörn
Pyrosequencing-based screening for genetic polymorphisms in cytochrome P450 2B6 of potential clinical relevance.
Pharmacogenomics 2006;7(7):995-1002.
2006: Oertel Bruno G; Schmidt Ronald; Schneider Andreas; Geisslinger Gerd; Lötsch Jörn
The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers.
Pharmacogenetics and genomics 2006;16(9):625-36.
2006: Weigert Andreas; Johann Axel M; von Knethen Andreas; Schmidt Helmut; Geisslinger Gerd; Brüne Bernhard
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.
Blood 2006;108(5):1635-42.
2006: Michelson Georg; Wärntges Simone; Leidig Steffen; Lötsch Jörn; Geisslinger Gerd
Nimodipine plasma concentration and retinal blood flow in healthy subjects.
Investigative ophthalmology & visual science 2006;47(8):3479-86.
2006: Scholich Klaus; Geisslinger Gerd
Is mPGES-1 a promising target for pain therapy?
Trends in pharmacological sciences 2006;27(8):399-401.
2006: Brenneis Christian; Maier Thorsten J; Schmidt Ronald; Hofacker Annette; Zulauf Lars; Jakobsson Per-Johan; Scholich Klaus; Geisslinger Gerd
Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1352-60.
2006: Lötsch Jörn; Geisslinger Gerd
Misestimating the role of an active metabolite when modeling the effects after administration of the parent compound only.
Clinical pharmacology and therapeutics 2006;80(1):95-7.
2006: Niederberger Ellen; Schmidtko Achim; Coste Ovidiu; Marian Claudiu; Ehnert Corina; Geisslinger Gerd
The glutamate transporter GLAST is involved in spinal nociceptive processing.
Biochemical and biophysical research communications 2006;346(2):393-9.
2006: Janssen Astrid; Maier Thorsten J; Schiffmann Susanne; Coste Ovidiu; Seegel Maic; Geisslinger Gerd; Grösch Sabine
Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.
European journal of pharmacology 2006;540(1-3):24-33.
2006: Grösch Sabine; Maier Thorsten Jürgen; Schiffmann Susanne; Geisslinger Gerd
Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.
Journal of the National Cancer Institute 2006;98(11):736-47.
2006: Schmidt Ronald; Bremerich Dorothee H; Geisslinger Gerd
High sensitive determination of sufentanil in human plasma of parturients and neonates following patient-controlled epidural analgesia (PCEA).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;836(1-2):98-107.
2006: Lötsch J; Geisslinger G
Relevance of frequent mu-opioid receptor polymorphisms for opioid activity in healthy volunteers.
The pharmacogenomics journal 2006;6(3):200-10.
2006: Niederberger Ellen; Manderscheid Christine; Geisslinger Gerd
Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib.
Biochemical and biophysical research communications 2006;342(3):940-8.
2006: Tegeder Irmgard; Geisslinger Gerd
Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?
Naunyn-Schmiedeberg's archives of pharmacology 2006;373(1):1-17.
2006: Burian M; Neumann T; Weber M; Brandt R; Geisslinger G; Mitrovic V; Hamm C
Nickel release, a possible indicator for the duration of antiplatelet treatment, from a nickel cardiac device in vivo: a study in patients with atrial septal defects implanted with an Amplatzer occluder.
International journal of clinical pharmacology and therapeutics 2006;44(3):107-12.
2006: Rohrbacher Maren; Kirchhof Anja; Skarke Carsten; Geisslinger Gerd; Lötsch Jörn
Rapid identification of three functionally relevant polymorphisms in the OATP1B1 transporter gene using Pyrosequencing.
Pharmacogenomics 2006;7(2):167-76.
2006: Lötsch Jörn; Geisslinger Gerd
Current evidence for a genetic modulation of the response to analgesics.
Pain 2006;121(1-2):1-5.
2006: Lötsch Jörn; Skarke Carsten; Wieting Johannes; Oertel Bruno Georg; Schmidt Helmut; Brockmöller Jürgen; Geisslinger Gerd
Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.
Clinical pharmacology and therapeutics 2006;79(1):72-89.
2006: Lötsch Jörn; Skarke Carsten; Schmidt Helmut; Rohrbacher Maren; Hofmann Ute; Schwab Matthias; Geisslinger Gerd
Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites.
Clinical pharmacology and therapeutics 2006;79(1):35-48.
2006: Lötsch Jörn; Dudziak Rafael; Freynhagen Rainer; Marschner Jürgen; Geisslinger Gerd
Fatal respiratory depression after multiple intravenous morphine injections.
Clinical pharmacokinetics 2006;45(11):1051-60.
2005: Skarke Carsten; Kirchhof Anja; Geisslinger Gerd; Lötsch Jörn
Rapid genotyping for relevant CYP1A2 alleles by pyrosequencing.
European journal of clinical pharmacology 2005;61(12):887-92.
2005: Schmidt Ronald; Coste Ovidiu; Geisslinger Gerd
LC-MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;826(1-2):188-97.
2005: Lötsch J; Freynhagen R; Geisslinger G
[Are polymorphisms in the mu-opioid receptor important for opioid therapy?]
Schmerz (Berlin, Germany) 2005;19(5):378-82, 384-5.
2005: Hofacker Annette; Coste Ovidiu; Nguyen Hong-Van; Marian Claudiu; Scholich Klaus; Geisslinger Gerd
Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(39):9005-9.
2005: Lötsch Jörn; Skarke Carsten; Schneider Andreas; Hummel Thomas; Geisslinger Gerd
The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression.
Clinical pharmacology and therapeutics 2005;78(3):278-87.
2005: Burian Maria; Geisslinger Gerd
COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites.
Pharmacology & therapeutics 2005;107(2):139-54.
2005: Skarke Carsten; Geisslinger Gerd; Lötsch Jörn
Is morphine-3-glucuronide of therapeutic relevance?
Pain 2005;116(3):177-80.
2005: Maier Thorsten Jürgen; Janssen Astrid; Schmidt Ronald; Geisslinger Gerd; Grösch Sabine
Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1353-5.
2005: Kunz Susanne; Tegeder Irmgard; Coste Ovidiu; Marian Claudiu; Pfenninger Anja; Corvey Carsten; Karas Michael; Geisslinger Gerd; Niederberger Ellen
Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models.
Neuroscience letters 2005;381(3):289-93.
2005: Kämpfer Heiko; Schmidt Ronald; Geisslinger Gerd; Pfeilschifter Josef; Frank Stefan
Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing.
Diabetes 2005;54(5):1543-51.
2005: Schmidtko Achim; Del Turco Domenico; Coste Ovidiu; Ehnert Corina; Niederberger Ellen; Ruth Peter; Deller Thomas; Geisslinger Gerd; Tegeder Irmgard
Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord.
Pain 2005;115(1-2):171-81.
2005: Grösch Sabine; Schilling Karin; Janssen Astrid; Maier Thorsten J; Niederberger Ellen; Geisslinger Gerd
Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53.
Biochemical pharmacology 2005;69(5):831-9.
2005: Lötsch Jörn; Geisslinger Gerd
Are mu-opioid receptor polymorphisms important for clinical opioid therapy?
Trends in molecular medicine 2005;11(2):82-9.
2005: Darimont J; Grösch S; Skarke C; Geisslinger G; Lötsch J
Comparison of two screening methods for in-house genotyping in clinical pharmacology units.
International journal of clinical pharmacology and therapeutics 2005;43(1):17-22.
2004: Skarke Carsten; Langer Michael; Jarrar Marwan; Schmidt Helmut; Geisslinger Gerd; Lötsch Jörn
Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.
Anesthesiology 2004;101(6):1394-9.
2004: Glienke Wolfgang; Dolgova Yuliya; Müller Iris; Grösch Sabine; Binder Jochen; Geisslinger Gerd; Jonas Dietger
Induction of apoptosis in human prostate stromal cells by 4-hydroxytamoxifen: an alternative therapy for benign prostate hyperplasia.
World journal of urology 2004;22(6):452-6.
2004: Tegeder Irmgard; Geisslinger Gerd
Opioids as modulators of cell death and survival--unraveling mechanisms and revealing new indications.
Pharmacological reviews 2004;56(3):351-69.
2004: Pierre Sandra C; Häusler Julia; Birod Kerstin; Geisslinger Gerd; Scholich Klaus
PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
The EMBO journal 2004;23(15):3031-40.
2004: Kunz Susanne; Niederberger Ellen; Ehnert Corina; Coste Ovidiu; Pfenninger Anja; Kruip Jochen; Wendrich Thomas M; Schmidtko Achim; Tegeder Irmgard; Geisslinger Gerd
The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia.
Pain 2004;110(1-2):409-18.
2004: Niederberger Ellen; Manderscheid Christine; Grösch Sabine; Schmidt Helmut; Ehnert Corina; Geisslinger Gerd
Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells.
Biochemical pharmacology 2004;68(2):341-50.
2004: Maier Thorsten Jürgen; Schilling Karin; Schmidt Ronald; Geisslinger Gerd; Grösch Sabine
Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells.
Biochemical pharmacology 2004;67(8):1469-78.
2004: Skarke C; Grösch S; Geisslinger G; Lötsch J
Single-step identification of all length polymorphisms in the UGT1A1 gene promoter.
International journal of clinical pharmacology and therapeutics 2004;42(3):133-8.
2004: Skarke Carsten; Kirchhof Anja; Geisslinger Gerd; Lötsch Jörn
Comprehensive mu-opioid-receptor genotyping by pyrosequencing.
Clinical chemistry 2004;50(3):640-4.
2004: Tegeder Irmgard; Del Turco Domenico; Schmidtko Achim; Sausbier Matthias; Feil Robert; Hofmann Franz; Deller Thomas; Ruth Peter; Geisslinger Gerd
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3253-7.
2004: Tegeder Irmgard; Niederberger Ellen; Schmidt Ronald; Kunz Susanne; Gühring Hans; Ritzeler Olaf; Michaelis Martin; Geisslinger Gerd
Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(7):1637-45.
2004: Ehnert Corina; Tegeder Irmgard; Pierre Sandra; Birod Kerstin; Nguyen Hong-Van; Schmidtko Achim; Geisslinger Gerd; Scholich Klaus
Protein associated with Myc (PAM) is involved in spinal nociceptive processing.
Journal of neurochemistry 2004;88(4):948-57.
2004: Lötsch J; Kobal G; Geisslinger G
Programming of a flexible computer simulation to visualize pharmacokinetic-pharmacodynamic models.
International journal of clinical pharmacology and therapeutics 2004;42(1):15-22.
2004: Lötsch Jörn; Skarke Carsten; Liefhold Jürgen; Geisslinger Gerd
Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives.
Clinical pharmacokinetics 2004;43(14):983-1013.
2004: Broom D C; Samad T A; Kohno T; Tegeder I; Geisslinger G; Woolf C J
Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain.
Neuroscience 2004;124(4):891-900.
2004: Schmidt Helmut; Woodcock Barry G; Geisslinger Gerd
Benefit-risk assessment of rofecoxib in the treatment of osteoarthritis.
Drug safety : an international journal of medical toxicology and drug experience 2004;27(3):185-96.
2003: Burian M; Geisslinger G
[Clinical pharmacology of the selective COX-2 inhibitors]
Der Orthopäde 2003;32(12):1078-87.
2003: Bräutigam Lutz; Seegel Maic; Tegeder Irmgard; Schmidt Helmut; Meier Silke; Podda Maurizio; Kaufmann Roland; Grundmann-Kollmann Marcella; Geisslinger Gerd
Determination of 8-methoxypsoralen in human plasma, and microdialysates using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;798(2):223-9.
2003: Skarke Carsten; Jarrar Marwan; Schmidt Helmut; Kauert Gerold; Langer Michael; Geisslinger Gerd; Lötsch Jörn
Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers.
Pharmacogenetics 2003;13(11):651-60.
2003: Lötsch Jörn; Skarke Carsten; Geisslinger Gerd
Simultaneous screening for three mutations in the ABCB1 gene.
Genomics 2003;82(5):503-10.
2003: Skarke Carsten; Jarrar Marwan; Erb Katharina; Schmidt Helmut; Geisslinger Gerd; Lötsch Jörn
Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine.
Clinical pharmacology and therapeutics 2003;74(4):303-11.
2003: Skarke Carsten; Schmidt Helmut; Geisslinger Gerd; Darimont Jutta; Lötsch Jörn
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome.
British journal of clinical pharmacology 2003;56(2):228-31.
2003: Burian Maria; Tegeder Irmgard; Seegel Maic; Geisslinger Gerd
Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain.
Clinical pharmacology and therapeutics 2003;74(2):113-20.
2003: Grösch Sabine; Tegeder Irmgard; Schilling Karin; Maier Thorsten J; Niederberger Ellen; Geisslinger Gerd
Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1316-8.
2003: Tegeder Irmgard; Bräutigam Lutz; Seegel Maic; Al-Dam Ahmed; Turowski Bernd; Geisslinger Gerd; Kovács Adorján F
Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer.
Clinical pharmacology and therapeutics 2003;73(5):417-26.
2003: Kämpfer Heiko; Bräutigam Lutz; Geisslinger Gerd; Pfeilschifter Josef; Frank Stefan
Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair.
The Journal of investigative dermatology 2003;120(5):880-90.
2003: Bräutigam Lutz; Nefflen Jens U; Geisslinger Gerd
Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;788(2):309-15.
2003: Tegeder Irmgard; Meier Silke; Burian Maria; Schmidt Helmut; Geisslinger Gerd; Lötsch Jörn
Peripheral opioid analgesia in experimental human pain models.
Brain : a journal of neurology 2003;126(Pt 5):1092-102.
2003: Maihöfner Christian; Charalambous Michalis Panayiotou; Bhambra Upinder; Lightfoot Tracy; Geisslinger Gerd; Gooderham Nigel J;
Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer.
Carcinogenesis 2003;24(4):665-71.
2003: Tegeder Irmgard; Grösch Sabine; Schmidtko Achim; Häussler Annett; Schmidt Helmut; Niederberger Ellen; Scholich Klaus; Geisslinger Gerd
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
Cancer research 2003;63(8):1846-52.
2003: Schmidtko Achim; Ruth Peter; Geisslinger Gerd; Tegeder Irmgard
Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;8(2):89-94.
2003: Niederberger Ellen; Tegeder Irmgard; Schäfer Christine; Seegel Maic; Grösch Sabine; Geisslinger Gerd
Opposite effects of rofecoxib on nuclear factor-kappaB and activating protein-1 activation.
The Journal of pharmacology and experimental therapeutics 2003;304(3):1153-60.
2003: Skarke Carsten; Darimont Jutta; Schmidt Helmut; Geisslinger Gerd; Lötsch Jörn
Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers.
Clinical pharmacology and therapeutics 2003;73(1):107-21.
2003: Niederberger E; Schmidtko A; Rothstein J D; Geisslinger G; Tegeder I
Modulation of spinal nociceptive processing through the glutamate transporter GLT-1.
Neuroscience 2003;116(1):81-7.
2002: Grundmann-Kollmann Marcella; Podda Maurizio; Bräutigam Lutz; Hardt-Weinelt Katja; Ludwig Ralf J; Geisslinger Gerd; Kaufmann Roland; Tegeder Irmgard
Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration.
British journal of clinical pharmacology 2002;54(5):535-9.
2002: Burian Maria; Grösch Sabine; Tegeder Irmgard; Geisslinger Gerd
Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population.
British journal of clinical pharmacology 2002;54(5):518-21.
2002: Lötsch Jörn; Schmidt Rodolfo; Vetter Gregor; Schmidt Helmut; Niederberger Ellen; Geisslinger Gerd; Tegeder Irmgard
Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein.
Journal of neurochemistry 2002;83(2):241-8.
2002: Tegeder Irmgard; Schmidtko Achim; Niederberger Ellen; Ruth Peter; Geisslinger Gerd
Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats.
Neuroscience letters 2002;332(2):146-50.
2002: Lötsch Jörn; Zimmermann Michael; Darimont Jutta; Marx Claudia; Dudziak Rafael; Skarke Carsten; Geisslinger Gerd
Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?
Anesthesiology 2002;97(4):814-9.
2002: Tegeder L; Zimmermann J; Meller S T; Geisslinger G
Release of algesic substances in human experimental muscle pain.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(8):393-402.
2002: Lötsch Jörn; Skarke Carsten; Schmidt Helmut; Liefhold Jürgen; Geisslinger Gerd
Pharmacokinetic modeling to predict morphine and morphine-6-glucuronide plasma concentrations in healthy young volunteers.
Clinical pharmacology and therapeutics 2002;72(2):151-62.
2002: Lötsch Jörn; Schmidt Rodolfo; Vetter Gregor; Schmidt Helmut; Skarke Carsten; Niederberger Ellen; Geisslinger Gerd; Tegeder Irmgard
The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats.
Neuroscience letters 2002;329(2):145-8.
2002: Tegeder Irmgard; Schmidtko Achim; Bräutigam Lutz; Kirschbaum Andreas; Geisslinger Gerd; Lötsch Jörn
Tissue distribution of imipenem in critically ill patients.
Clinical pharmacology and therapeutics 2002;71(5):325-33.
2002: Lötsch Jörn; Sperker Bernhard; Kroemer Heyo K; Geisslinger Gerd
Verapamil decreases glucuronidase activity in the gut.
Biochemical pharmacology 2002;63(8):1575-8.
2002: Tegeder Irmgard; Bräutigam Lutz; Podda Maurizio; Meier Silke; Kaufmann Roland; Geisslinger Gerd; Grundmann-Kollmann Marcella
Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen.
Clinical pharmacology and therapeutics 2002;71(3):153-61.
2002: Lötsch Jörn; Skarke Carsten; Grösch Sabine; Darimont Jutta; Schmidt Helmut; Geisslinger Gerd
The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine.
Pharmacogenetics 2002;12(1):3-9.
2002: Schmidt Helmut; Geisslinger Gerd
[Current post-marketing information. Effects and adverse effects of celecoxib]
Pharmazie in unserer Zeit 2002;31(2):180-7.
2002: Lotsch Jorn; Skarke Carsten; Tegeder Irmgard; Geisslinger Gerd
Drug interactions with patient-controlled analgesia.
Clinical pharmacokinetics 2002;41(1):31-57.
2001: Lötsch J; Skarke C; Schmidt H; Grösch S; Geisslinger G
The transfer half-life of morphine-6-glucuronide from plasma to effect site assessed by pupil size measurement in healthy volunteers.
Anesthesiology 2001;95(6):1329-38.
2001: Grösch S; Niederberger E; Lötsch J; Skarke C; Geisslinger G
A rapid screening method for a single nucleotide polymorphism (SNP) in the human MOR gene.
British journal of clinical pharmacology 2001;52(6):711-4.
2001: Grösch S; Tegeder I; Niederberger E; Bräutigam L; Geisslinger G
COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2742-4.
2001: Tegeder I; Niederberger E; Vetter G; Bräutigam L; Geisslinger G
Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord.
Journal of neurochemistry 2001;79(4):777-86.
2001: Ihmsen H; Geisslinger G; Schüttler J
Stereoselective pharmacokinetics of ketamine: R(-)-ketamine inhibits the elimination of S(+)-ketamine.
Clinical pharmacology and therapeutics 2001;70(5):431-8.
2001: Lötsch J; Muth-Selbach U; Tegeder I; Brune K; Geisslinger G
Simultaneous fitting of R- and S-ibuprofen plasma concentrations after oral administration of the racemate.
British journal of clinical pharmacology 2001;52(4):387-98.
2001: Tegeder I; Pfeilschifter J; Geisslinger G
Cyclooxygenase-independent actions of cyclooxygenase inhibitors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(12):2057-72.
2001: Lötsch J; Darimont J; Skarke C; Zimmermann M; Hummel T; Geisslinger G
Effects of the opioid remifentanil on olfactory function in healthy volunteers.
Life sciences 2001;69(19):2279-85.
2001: Bräutigam L; Vetter G; Tegeder I; Heinkele G; Geisslinger G
Determination of celecoxib in human plasma and rat microdialysis samples by liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2001;761(2):203-12.
2001: Franzen R; Pautz A; Bräutigam L; Geisslinger G; Pfeilschifter J; Huwiler A
Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells.
The Journal of biological chemistry 2001;276(38):35382-9.
2001: Tegeder I; Lötsch J; Kinzig-Schippers M; Sörgel F; Kelm G R; Meller S T; Geisslinger G
Comparison of tissue concentrations after intramuscular and topical administration of ketoprofen.
Pharmaceutical research 2001;18(7):980-6.
2001: Niederberger E; Tegeder I; Vetter G; Schmidtko A; Schmidt H; Euchenhofer C; Bräutigam L; Grösch S; Geisslinger G
Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1622-4.
2001: Schmidt H; Geisslinger G
[Selective cyclooxygenase-2 inhibitor. Pharmacology and state of knowledge following commercial availability]
Schmerz (Berlin, Germany) 2001;15(3):207-19.
2001: Vetter G; Geisslinger G; Tegeder I
Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation.
Pain 2001;92(1-2):213-8.
2001: Tegeder I; Niederberger E; Israr E; Gühring H; Brune K; Euchenhofer C; Grösch S; Geisslinger G
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):595-7.
2001: Bruggera R; Reichel C; Garcia Alia B; Brune K; Yamamoto T; Tegeder I; Geisslinger G;
Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and other fatty acid-like xenobiotics.
Biochemical pharmacology 2001;61(6):651-6.
2001: Gühring H; Tegeder I; Lötsch J; Pahl A; Werner U; Reeh P W; Rehse K; Brune K; Geisslinger G
Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50(2):83-8.
2001: Tegeder I; Niederberger E; Israr E; Gühring H; Brune K; Euchenhofer C; Grösch S; Geisslinger G
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):2-4.
2001: Lötsch J; Geisslinger G
Morphine-6-glucuronide: an analgesic of the future?
Clinical pharmacokinetics 2001;40(7):485-99.
2000: Grosser K; Oelkers R; Hummel T; Geisslinger G; Brune K; Kobal G; Lötsch J
Olfactory and trigeminal event-related potentials in migraine.
Cephalalgia : an international journal of headache 2000;20(7):621-31.
2000: Maihöfner C; Euchenhofer C; Tegeder I; Beck K F; Pfeilschifter J; Geisslinger G
Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation.
Neuroscience letters 2000;290(1):71-5.
2000: Geisslinger G; Muth-Selbach U; Coste O; Vetter G; Schrödter A; Schaible H G; Brune K; Tegeder I
Inhibition of noxious stimulus-induced spinal prostaglandin E2 release by flurbiprofen enantiomers: a microdialysis study.
Journal of neurochemistry 2000;74(5):2094-100.
2000: Albrecht S; Fechner J; Geisslinger G; Maass A B; Upadhyaya B; Moecke H; Haigh C; Schüttler J
Postoperative pain control following remifentanil-based anaesthesia for major abdominal surgery.
Anaesthesia 2000;55(4):315-22.
2000: Tegeder I; Neupert W; Gühring H; Geisslinger G
Effects of selective and unselective cyclooxygenase inhibitors on prostanoid release from various rat organs.
The Journal of pharmacology and experimental therapeutics 2000;292(3):1161-8.
2000: Dormann H; Muth-Selbach U; Krebs S; Criegee-Rieck M; Tegeder I; Schneider H T; Hahn E G; Levy M; Brune K; Geisslinger G
Incidence and costs of adverse drug reactions during hospitalisation: computerised monitoring versus stimulated spontaneous reporting.
Drug safety : an international journal of medical toxicology and drug experience 2000;22(2):161-8.
2000: Maihöfner C; Tegeder I; Euchenhofer C; deWitt D; Brune K; Bang R; Neuhuber W; Geisslinger G
Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord.
Neuroscience 2000;101(4):1093-108.
1999: Tegeder I; Lötsch J; Geisslinger G
Pharmacokinetics of opioids in liver disease.
Clinical pharmacokinetics 1999;37(1):17-40.
1999: Muth-Selbach U S; Tegeder I; Brune K; Geisslinger G
Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation.
Anesthesiology 1999;91(1):231-9.
1999: Tegeder I; Geisslinger G; Lötsch J
[Therapy with opioids in liver or renal failure]
Schmerz (Berlin, Germany) 1999;13(3):183-95.
1999: Albrecht S; Ihmsen H; Hering W; Geisslinger G; Dingemanse J; Schwilden H; Schüttler J
The effect of age on the pharmacokinetics and pharmacodynamics of midazolam.
Clinical pharmacology and therapeutics 1999;65(6):630-9.
1999: Oelkers R; Grosser K; Lang E; Geisslinger G; Kobal G; Brune K; Lötsch J
Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency.
Brain : a journal of neurology 1999;122 ( Pt 6)():1147-55.
1999: Tegeder I; Lötsch J; Krebs S; Muth-Selbach U; Brune K; Geisslinger G
Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state.
Clinical pharmacology and therapeutics 1999;65(5):533-44.
1999: Tegeder I; Levy M; Muth-Selbach U; Oelkers R; Neumann F; Dormann H; Azaz-Livshits T; Criegee-Rieck M; Schneider H T; Hahn E; Brune K; Geisslinger G
Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals.
British journal of clinical pharmacology 1999;47(5):557-64.
1999: Tegeder I; Muth-Selbach U; Lötsch J; Rüsing G; Oelkers R; Brune K; Meller S; Kelm G R; Sörgel F; Geisslinger G
Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration.
Clinical pharmacology and therapeutics 1999;65(4):357-68.
1999: Lötsch J; Weiss M; Ahne G; Kobal G; Geisslinger G
Pharmacokinetic modeling of M6G formation after oral administration of morphine in healthy volunteers.
Anesthesiology 1999;90(4):1026-38.
1999: Tegeder I; Neumann F; Bremer F; Brune K; Lötsch J; Geisslinger G
Pharmacokinetics of meropenem in critically ill patients with acute renal failure undergoing continuous venovenous hemofiltration.
Clinical pharmacology and therapeutics 1999;65(1):50-7.
1999: Koppert W; Likar R; Geisslinger G; Zeck S; Schmelz M; Sittl R
Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiation.
Anesthesia and analgesia 1999;88(1):117-22.
1999: Erb K; Brugger R; Williams K; Geisslinger G
Stereoselective disposition of tiaprofenic acid enantiomers in rats.
Chirality 1999;11(2):103-8.
1998: Beiche F; Brune K; Geisslinger G; Goppelt-Struebe M
Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1998;47(12):482-7.
1998: Lötsch J; Kobal G; Geisslinger G
No contribution of morphine-6-glucuronide to clinical morphine effects after short-term administration.
Clinical neuropharmacology 1998;21(6):351-4.
1998: Scheuerer S; Hall S D; Williams K M; Geisslinger G
Effect of clofibrate on the chiral inversion of ibuprofen in healthy volunteers.
Clinical pharmacology and therapeutics 1998;64(2):168-76.
1998: Lötsch J; Weiss M; Kobal G; Geisslinger G
Pharmacokinetics of morphine-6-glucuronide and its formation from morphine after intravenous administration.
Clinical pharmacology and therapeutics 1998;63(6):629-39.
1998: Euchenhofer C; Maihófner C; Brune K; Tegeder I; Geisslinger G
Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat.
Neuroscience letters 1998;248(1):25-8.
1998: Scheuerer S; Williams K M; Brugger R; McLachlan A J; Brune K; Day R O; Geisslinger G
Effect of clofibrate on the chiral disposition of ibuprofen in rats.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1132-8.
1998: Kleingeist B; Böcker R; Geisslinger G; Brugger R
Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 1998;1(1):38-46.
1997: Tegeder I; Bremer F; Oelkers R; Schobel H; Schüttler J; Brune K; Geisslinger G
Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration.
Antimicrobial agents and chemotherapy 1997;41(12):2640-5.
1997: Lötsch J; Kobal G; Stockmann A; Brune K; Geisslinger G
Lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers.
Anesthesiology 1997;87(6):1348-58.
1997: Neupert W; Brugger R; Euchenhofer C; Brune K; Geisslinger G
Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases.
British journal of pharmacology 1997;122(3):487-92.
1997: Erb K; Liebel J T; Tegeder I; Zeilhofer H U; Brune K; Geisslinger G
Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test.
Neuroreport 1997;8(8):1967-70.
1997: Geisslinger G; Brune K; Kobal G; Lötsch J
Intravenous morphine-6-glucuronide (M6G) is devoid of analgesic activity in man.
Pain 1997;70(2-3):289-90.
1997: Reichel C; Brugger R; Bang H; Geisslinger G; Brune K
Molecular cloning and expression of a 2-arylpropionyl-coenzyme A epimerase: a key enzyme in the inversion metabolism of ibuprofen.
Molecular pharmacology 1997;51(4):576-82.
1997: Oelkers R; Neupert W; Williams K M; Brune K; Geisslinger G
Disposition and effects of flurbiprofen enantiomers in human serum and blister fluid.
British journal of clinical pharmacology 1997;43(2):145-53.
1997: Hummel T; Cramer O; Mohammadian P; Geisslinger G; Pauli E; Kobal G
Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets.
European journal of clinical pharmacology 1997;52(2):107-14.
1997: Scheuren N; Neupert W; Ionac M; Neuhuber W; Brune K; Geisslinger G
Peripheral noxious stimulation releases spinal PGE2 during the first phase in the formalin assay of the rat.
Life sciences 1997;60(21):PL 295-300.
1996: Hering W J; Ihmsen H; Langer H; Uhrlau C; Dinkel M; Geisslinger G; Schüttler J
Pharmacokinetic-pharmacodynamic modeling of the new steroid hypnotic eltanolone in healthy volunteers.
Anesthesiology 1996;85(6):1290-9.
1996: Neupert W; Oelkers R; Brune K; Geisslinger G
A new reliable chemiluminescence immunoassay (CLIA) for prostaglandin E2 using enhanced luminol as substrate.
Prostaglandins 1996;52(5):385-401.
1996: Geisslinger G; Peskar B A; Pallapies D; Sittl R; Levy M; Brune K
The effects on platelet aggregation and prostanoid biosynthesis of two parenteral analgesics: ketorolac tromethamine and dipyrone.
Thrombosis and haemostasis 1996;76(4):592-7.
1996: Oelkers R; Ionac M; Erb K; Brune K; Geisslinger G
Transfer of different nonsteroidal antiinflammatory drugs via the lymphatic system in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(10):1107-10.
1996: Brugger R; García Alía B; Reichel C; Waibel R; Menzel S; Brune K; Geisslinger G
Isolation and characterization of rat liver microsomal R-ibuprofenoyl-CoA synthetase.
Biochemical pharmacology 1996;52(7):1007-13.
1996: Lötsch J; Stockmann A; Kobal G; Brune K; Waibel R; Schmidt N; Geisslinger G
Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers.
Clinical pharmacology and therapeutics 1996;60(3):316-25.
1996: Geisslinger G; Böcker R; Levy M
High-performance liquid chromatographic analysis of dipyrone metabolites to study their formation in human liver microsomes.
Pharmaceutical research 1996;13(8):1272-5.
1996: Ionac M; Oelkers R; Brune K; Geisslinger G; Bordos D
Lymph distribution of different non-steroidal anti-inflammatory drugs assessed by microsurgical cannulation of the thoracic duct in rat.
Romanian journal of internal medicine = Revue roumaine de médecine interne 1996;34(3-4):239-51.
1996: Beiche F; Scheuerer S; Brune K; Geisslinger G; Goppelt-Struebe M
Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation.
FEBS letters 1996;390(2):165-9.
1996: Geisslinger G; Schaible H G
New insights into the site and mode of antinociceptive action of flurbiprofen enantiomers.
Journal of clinical pharmacology 1996;36(6):513-20.
1996: Ionac M; Bordos D; Geisslinger G; Brune K
[An experimental model of the microsurgical cannulation of the thoracic duct in the rat]
Chirurgia (Bucharest, Romania : 1990) 1996;45(3):147-9.
1996: Ionac M; Geisslinger G; Brune K; Bordos D
[A microsurgical approach to drainage of the thoracic duct in the rat]
Revista medico-chirurgicala? a Societa?t?ii de Medici s¸i Naturalis¸ti din Ias¸i 1996;100(1-2):112-7.
1996: Geisslinger G; Menzel S; Brune K
Stereospecific determination of tiaprofenic acid in plasma: problems with drug degradation.
Journal of chromatography. B, Biomedical applications 1996;675(1):77-81.
1995: Lötsch J; Mohammadian P; Hummel T; Florin S; Brune K; Geisslinger G; Kobal G
Effects of azapropazone on pain-related brain activity in human subjects.
British journal of clinical pharmacology 1995;40(6):545-52.
1995: Reichel C; Bang H; Brune K; Geisslinger G; Menzel S
2-Arylpropionyl-CoA epimerase: partial peptide sequences and tissue localization.
Biochemical pharmacology 1995;50(11):1803-6.
1995: Lötsch J; Geisslinger G; Mohammadian P; Brune K; Kobal G
Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects.
British journal of clinical pharmacology 1995;40(4):339-46.
1995: Geisslinger G; Hering W; Kamp H D; Vollmers K O
Pharmacokinetics of ketamine enantiomers.
British journal of anaesthesia 1995;75(4):506-7.
1995: Kilo S; Forster C; Geisslinger G; Brune K; Handwerker H O
Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man.
Pain 1995;62(2):187-93.
1995: Geisslinger G; Menzel S; Wissel K; Brune K
Pharmacokinetics of ketoprofen enantiomers after different doses of the racemate.
British journal of clinical pharmacology 1995;40(1):73-5.
1995: Hering W; Schlecht R; Geisslinger G; Biburger G; Dinkel M; Brune K; Rügheimer E
EEG analysis and pharmacodynamic modelling after intravenous bolus injection of eltanolone (pregnanolone).
European journal of anaesthesiology 1995;12(4):407-15.
1994: Hering W; Geisslinger G; Kamp H D; Dinkel M; Tschaikowsky K; Rügheimer E; Brune K
Changes in the EEG power spectrum after midazolam anaesthesia combined with racemic or S- (+) ketamine.
Acta anaesthesiologica Scandinavica 1994;38(7):719-23.
1994: Menzel S; Waibel R; Brune K; Geisslinger G
Is the formation of R-ibuprofenyl-adenylate the first stereoselective step of chiral inversion?
Biochemical pharmacology 1994;48(5):1056-8.
1994: Kobal G; Hummel C; Gruber M; Geisslinger G; Hummel T
Dose-related effects of ibuprofen on pain-related potentials.
British journal of clinical pharmacology 1994;37(5):445-52.
1994: Schmidt N; Brune K; Geisslinger G
Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum.
European journal of pharmacology 1994;255(1-3):245-7.
1994: Geisslinger G; Lötsch J; Menzel S; Kobal G; Brune K
Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers.
British journal of clinical pharmacology 1994;37(4):392-4.
1994: Pallapies D; Peskar B A; Brune K; Geisslinger G
Effects on platelet functions and pharmacokinetics of azapropazone and ketorolac tromethamine given as single parenteral doses.
British journal of clinical pharmacology 1994;37(4):335-9.
1994: Menzel S; Sauernheimer C; Brune K; Geisslinger G
Is the inversion from R- to S-ketoprofen concentration dependent? Investigations in rats in vivo and in vitro.
Biochemical pharmacology 1994;47(7):1267-70.
1994: Geisslinger G; Ferreira S H; Menzel S; Schlott D; Brune K
Antinociceptive actions of R(-)-flurbiprofen--a non-cyclooxygenase inhibiting 2-arylpropionic acid--in rats.
Life sciences 1994;54(10):PL173-7.
1994: Schmidt N; Brune K; Williams K M; Geisslinger G
Stereoselective pharmacokinetics of methadone in beagle dogs.
Chirality 1994;6(6):492-5.
1993: Geisslinger G; Stock K P; Loew D; Bach G L; Brune K
Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis.
British journal of clinical pharmacology 1993;35(6):603-7.
1993: Geisslinger G; Hering W; Thomann P; Knoll R; Kamp H D; Brune K
Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method.
British journal of anaesthesia 1993;70(6):666-71.
1993: Schmidt N; Sittl R; Brune K; Geisslinger G
Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring.
Pharmaceutical research 1993;10(3):441-4.
1993: Hering W; Kamp H D; Geisslinger G
[Ketamine--unwanted effects and possible complications]
Klinische Anästhesiologie und Intensivtherapie 1993;42():71-86.
1993: Menzel S; Beck W S; Brune K; Geisslinger G
Stereoselectivity of biliary excretion of 2-arylpropionates in rats.
Chirality 1993;5(6):422-7.
1993: Menzel-Soglowek S; Geisslinger G; Brune K
Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines.
Agents and actions. Supplements 1993;44():23-9.
1993: Geisslinger G; Menzel-Soglowek S; Beck W S; Brune K
R-flurbiprofen: isomeric ballast or active entity of the racemic compound?
Agents and actions. Supplements 1993;44():31-6.
1992: Schmidt N; Brune K; Geisslinger G
Stereoselective determination of the enantiomers of methadone in plasma using high-performance liquid chromatography.
Journal of chromatography 1992;583(2):195-200.
1992: Brune K; Geisslinger G; Menzel-Soglowek S
Pure enantiomers of 2-arylpropionic acids: tools in pain research and improved drugs in rheumatology.
Journal of clinical pharmacology 1992;32(10):944-52.
1992: Menzel-Soglowek S; Geisslinger G; Beck W S; Brune K
Variability of inversion of (R)-flurbiprofen in different species.
Journal of pharmaceutical sciences 1992;81(9):888-91.
1992: Menzel-Soglowek S; Geisslinger G; Mollenhauer J; Brune K
Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism.
Biochemical pharmacology 1992;43(7):1487-92.
1992: Zeilhofer H U; Swandulla D; Geisslinger G; Brune K
Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons.
European journal of pharmacology 1992;213(1):155-8.
1992: Geisslinger G; Menzel-Soglowek S; Schuster O; Brune K
Stereoselective high-performance liquid chromatographic determination of flurbiprofen in human plasma.
Journal of chromatography 1992;573(1):163-7.
1991: Geisslinger G; Menzel-Soglowek S; Kamp H D; Brune K
Stereoselective high-performance liquid chromatographic determination of the enantiomers of ketamine and norketamine in plasma.
Journal of chromatography 1991;568(1):165-76.
1991: Kamp H D; Naujoks B; Geisslinger G
[Possibilities and limitations of intravenous anesthesia]
Therapeutische Umschau. Revue thérapeutique 1991;48(6):388-94.
1991: Brune K; Beck W S; Geisslinger G; Menzel-Soglowek S; Peskar B M; Peskar B A
Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition.
Experientia 1991;47(3):257-61.
1991: Beck W S; Geisslinger G; Engler H; Brune K
Pharmacokinetics of ibuprofen enantiomers in dogs.
Chirality 1991;3(3):165-9.
1991: Stock K P; Geisslinger G; Loew D; Beck W S; Bach G L; Brune K
S-ibuprofen versus ibuprofen-racemate. A randomized double-blind study in patients with rheumatoid arthritis.
Rheumatology international 1991;11(4-5):199-202.
1990: Menzel-Soglowek S; Geisslinger G; Brune K
Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral alpha 1-acid glycoprotein column.
Journal of chromatography 1990;532(2):295-303.
1990: Beck W S; Dietzel K; Geisslinger G; Engler H; Vergin H; Brune K
Effects of sodium salicylate on elimination kinetics of indomethacin and bile production in dogs.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):962-7.
1990: Moeller N; Dietzel K; Nuernberg B; Geisslinger G; Brune K
High-performance liquid chromatographic determination of pentazocine in plasma.
Journal of chromatography 1990;530(1):200-5.
1990: Dietzel K; Beck W S; Schneider H T; Geisslinger G; Brune K
The biliary elimination and enterohepatic circulation of ibuprofen in rats.
Pharmaceutical research 1990;7(1):87-90.
1990: Geisslinger G; Schuster O; Stock K P; Loew D; Bach G L; Brune K
Pharmacokinetics of S(+)- and R(-)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis.
European journal of clinical pharmacology 1990;38(5):493-7.
1989: Geisslinger G; Dietzel K; Bezler H; Nuernberg B; Brune K
Therapeutically relevant differences in the pharmacokinetical and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid.
International journal of clinical pharmacology, therapy, and toxicology 1989;27(7):324-8.
1989: Geisslinger G; Stock K P; Bach G L; Loew D; Brune K
Pharmacological differences between R(-)- and S(+)-ibuprofen.
Agents and actions 1989;27(3-4):455-7.
1989: Geisslinger G; Dietzel K; Loew D; Schuster O; Rau G; Lachmann G; Brune K
High-performance liquid chromatographic determination of ibuprofen, its metabolites and enantiomers in biological fluids.
Journal of chromatography 1989;491(1):139-49.

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