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Michael Gekle

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Hydrogen-Ion Concentration

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Co-Publications
Name
44
Freudinger, Ruth
39
Silbernagl, Stefan
34
Mildenberger, Sigrid
28
Schwerdt, Gerald
20
Sauvant, Christoph
13
Gassner, Birgit
13
Holzinger, Hildegard
10
Grossmann, Claudia
10
Drumm, Karina
8
Benesic, Andreas
8
Humpf, Hans-Ulrich
7
Oberleithner, Hans
7
Krug, Alexander
7
Thews, Oliver
6
Wünsch, S

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Publications

TOP 3
Grossmann C; Gekle M
New aspects of rapid aldosterone signaling.
Gekle Michael; Grossmann Claudia
Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?
Königs Maika; Mulac Dennis; Schwerdt Gerald; Gekle Michael; Humpf Hans-Ulrich
Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture.

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All Publications

2009: Grossmann C; Gekle M
New aspects of rapid aldosterone signaling.
Molecular and cellular endocrinology 2009;308(1-2):53-62.
2009: Gekle Michael; Grossmann Claudia
Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?
Pflügers Archiv : European journal of physiology 2009;458(2):231-46.
2009: Königs Maika; Mulac Dennis; Schwerdt Gerald; Gekle Michael; Humpf Hans-Ulrich
Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture.
Toxicology 2009;258(2-3):106-15.
2009: Schwerdt G; Königs M; Holzinger H; Humpf H U; Gekle M
Effects of the mycotoxin fumonisin B(1) on cell death in human kidney cells and human lung fibroblasts in primary culture.
Journal of applied toxicology : JAT 2009;29(2):174-82.
2009: Schwerdt Gerald; Holzinger Hildegard; Königs Maika; Humpf Hans-Ulrich; Gekle Michael
Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(1):209-13.
2009: Sauvant Christoph; Schneider Reinhard; Holzinger Hildegard; Renker Sylvia; Wanner Christoph; Gekle Michael
Implementation of an in vitro model system for investigation of reperfusion damage after renal ischemia.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009;24(5-6):567-76.
2008: Sauvant Christoph; Nowak Martin; Wirth Claudia; Schneider Bettina; Riemann Anne; Gekle Michael; Thews Oliver
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.
International journal of cancer. Journal international du cancer 2008;123(11):2532-42.
2008: Sauvant C; Thews O; Wirth C; Gekle M
Direct determination of intracellular daunorubicin in intact confluent monolayers of AT1 prostate carcinoma cells using a multiwell-multilabel counter.
Analytical biochemistry 2008;381(1):81-5.
2008: Grossmann Claudia; Gekle Michael
Nongenotropic aldosterone effects and the EGFR: interaction and biological relevance.
Steroids 2008;73(9-10):973-8.
2008: Kessler Wolfram; Budde Thomas; Gekle Michael; Fabian Anke; Schwab Albrecht
Activation of cell migration with fibroblast growth factor-2 requires calcium-sensitive potassium channels.
Pflügers Archiv : European journal of physiology 2008;456(5):813-23.
2008: Königs Maika; Schwerdt Gerald; Gekle Michael; Humpf Hans-Ulrich
Effects of the mycotoxin deoxynivalenol on human primary hepatocytes.
Molecular nutrition & food research 2008;52(7):830-9.
2008: Grossmann Claudia; Freudinger Ruth; Mildenberger Sigrid; Husse Britta; Gekle Michael
EF domains are sufficient for nongenomic mineralocorticoid receptor actions.
The Journal of biological chemistry 2008;283(11):7109-16.
2008: Thews Oliver; Gassner Birgit; Kelleher Debra K; Gekle Michael
Activity of drug efflux transporters in tumor cells under hypoxic conditions.
Advances in experimental medicine and biology 2008;614():157-64.
2007: Krug Alexander W; Kopprasch Steffi; Ziegler Christian G; Dippong Sandra; Catar Rusan A; Bornstein Stefan R; Morawietz Henning; Gekle Michael
Aldosterone rapidly induces leukocyte adhesion to endothelial cells: a new link between aldosterone and arteriosclerosis?
Hypertension 2007;50(5):e156-7.
2007: Husse Britta; Briest Wilfried; Homagk Lars; Isenberg Gerrit; Gekle Michael
Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(5):R1898-907.
2007: Königs Maika; Lenczyk Marlies; Schwerdt Gerald; Holzinger Hildegard; Gekle Michael; Humpf Hans-Ulrich
Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture.
Toxicology 2007;240(1-2):48-59.
2007: Grossmann Claudia; Gekle Michael
Non-classical actions of the mineralocorticoid receptor: misuse of EGF receptors?
Molecular and cellular endocrinology 2007;277(1-2):6-12.
2007: Grossmann Claudia; Krug Alexander W; Freudinger Ruth; Mildenberger Sigrid; Voelker Katharina; Gekle Michael
Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1790-800.
2007: Schwerdt Gerald; Kirchhoff Antje; Freudinger Ruth; Wollny Brigitte; Benesic Andreas; Gekle Michael
Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells.
Pediatric nephrology (Berlin, Germany) 2007;22(6):798-803.
2007: Gekle Michael; Mildenberger Sigrid; Freudinger Ruth; Grossmann Claudia
Altered collagen homeostasis in human aortic smooth muscle cells (HAoSMCs) induced by aldosterone.
Pflügers Archiv : European journal of physiology 2007;454(3):403-13.
2007: Schneider R; Sauvant C; Betz B; Otremba M; Fischer D; Holzinger H; Wanner C; Galle J; Gekle M
Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats.
American journal of physiology. Renal physiology 2007;292(5):F1599-605.
2007: Gekle M
Renal albumin handling: a look at the dark side of the filter.
Kidney international 2007;71(6):479-81.
2007: Schwerdt Gerald; Holzinger Hildegard; Sauvant Christoph; Königs Maika; Humpf Hans-Ulrich; Gekle Michael
Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture.
Toxicology 2007;232(1-2):57-67.
2007: Lotz Christopher; Kelleher Debra K; Gassner Birgit; Gekle Michael; Vaupel Peter; Thews Oliver
Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells.
Oncology reports 2007;17(1):239-44.
2007: Pfau Anja; Grossmann Claudia; Freudinger Ruth; Mildenberger Sigrid; Benesic Andreas; Gekle Michael
Ca2+ but not H2O2 modulates GRE-element activation by the human mineralocorticoid receptor in HEK cells.
Molecular and cellular endocrinology 2007;264(1-2):35-43.
2007: Thews Oliver; Gassner Birgit; Kelleher Debra K; Schwerdt Gerald; Gekle Michael
Impact of hypoxic and acidic extracellular conditions on cytotoxicity of chemotherapeutic drugs.
Advances in experimental medicine and biology 2007;599():155-61.
2006: Akimova Olga A; Grygorczyk Alexandra; Bundey Richard A; Bourcier Nathalie; Gekle Michael; Insel Paul A; Orlov Sergei N
Transient activation and delayed inhibition of Na+,K+,Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms.
The Journal of biological chemistry 2006;281(42):31317-25.
2006: Thews Oliver; Gassner Birgit; Kelleher Debra K; Schwerdt Gerald; Gekle Michael
Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs.
Neoplasia (New York, N.Y.) 2006;8(2):143-52.
2006: Sauvant Christoph; Holzinger Hildegard; Gekle Michael
Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3.
Journal of the American Society of Nephrology : JASN 2006;17(1):46-53.
2006: Schwerdt Gerald; Gordjani Nader; Benesic Andreas; Freudinger Ruth; Wollny Brigitte; Kirchhoff Antje; Gekle Michael
Chloroacetaldehyde- and acrolein-induced death of human proximal tubule cells.
Pediatric nephrology (Berlin, Germany) 2006;21(1):60-7.
2006: Benesic Andreas; Schwerdt Gerald; Freudinger Ruth; Mildenberger Sigrid; Groezinger Franziska; Wollny Brigitte; Kirchhoff Antje; Gekle Michael
Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.
Kidney & blood pressure research 2006;29(5):280-93.
2006: Drumm Karina; Kress Theresia R; Gassner Birgit; Krug Alexander W; Gekle Michael
Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC).
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006;17(1-2):21-8.
2005: Benesic Andreas; Schwerdt Gerald; Mildenberger Sigrid; Freudinger Ruth; Gordjani Nader; Gekle Michael
Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity.
Kidney international 2005;68(5):2029-41.
2005: Akimova A Olga; Bourcier Nathalie; Taurin Sebastien; Bundey Richard A; Grygorczyk Konrad; Gekle Michael; Insel Paul A; Dulin Nickolai O; Orlov Sergei N
Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A.
The Journal of physiology 2005;568(Pt 3):789-801.
2005: de Jong Marion; Barone Raffaella; Krenning Eric; Bernard Bert; Melis Marleen; Visser Theo; Gekle Michael; Willnow Thomas E; Walrand Stephan; Jamar François; Pauwels Stanislas
Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotide.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(10):1696-700.
2005: Grossmann Claudia; Benesic Andreas; Krug Alexander W; Freudinger Ruth; Mildenberger Sigrid; Gassner Birgit; Gekle Michael
Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions.
Molecular endocrinology (Baltimore, Md.) 2005;19(7):1697-710.
2005: Schwerdt Gerald; Freudinger Ruth; Schuster Claudia; Weber Florian; Thews Oliver; Gekle Michael
Cisplatin-induced apoptosis is enhanced by hypoxia and by inhibition of mitochondria in renal collecting duct cells.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):735-42.
2005: Blazer-Yost Bonnie L; West T Aaron; Stack Jamie; Peck Kerrie; Lahr Thomas F; Gekle Michael
Effect of the mycotoxin, ochratoxin A, on hormone-stimulated ion transport in a cultured cell model of the renal principal cell.
Pflügers Archiv : European journal of physiology 2005;450(1):53-60.
2005: Sauvant C; Holzinger H; Gekle M
Proximal tubular toxicity of ochratoxin A is amplified by simultaneous inhibition of the extracellular signal-regulated kinases 1/2.
The Journal of pharmacology and experimental therapeutics 2005;313(1):234-41.
2005: Gekle Michael; Sauvant Christoph; Schwerdt Gerald
Ochratoxin A at nanomolar concentrations: a signal modulator in renal cells.
Molecular nutrition & food research 2005;49(2):118-30.
2005: Weber Florian; Freudinger Ruth; Schwerdt Gerald; Gekle Michael
A rapid screening method to test apoptotic synergisms of ochratoxin A with other nephrotoxic substances.
Toxicology in vitro : an international journal published in association with BIBRA 2005;19(1):135-43.
2005: Sauvant Christoph; Holzinger Hildegard; Mildenberger Sigrid; Gekle Michael
Exposure to nephrotoxic ochratoxin A enhances collagen secretion in human renal proximal tubular cells.
Molecular nutrition & food research 2005;49(1):31-7.
2005: Gekle Michael
Renal tubule albumin transport.
Annual review of physiology 2005;67():573-94.
2005: Sauvant Christoph; Holzinger Hildegard; Gekle Michael
The nephrotoxin ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2005;15(1-4):125-34.
2004: Gekle Michael; Völker Katharina; Mildenberger Sigrid; Freudinger Ruth; Shull Gary E; Wiemann Martin
NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo.
American journal of physiology. Renal physiology 2004;287(3):F469-73.
2004: Ludwig Thomas; Riethmüller Christoph; Gekle Michael; Schwerdt Gerald; Oberleithner Hans
Nephrotoxicity of platinum complexes is related to basolateral organic cation transport.
Kidney international 2004;66(1):196-202.
2004: Grossmann Claudia; Freudinger Ruth; Mildenberger Sigrid; Krug Alexander W; Gekle Michael
Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na+ reabsorption.
American journal of physiology. Renal physiology 2004;286(6):F1226-31.
2004: Sauvant C; Hesse D; Holzinger H; Evans K K; Dantzler W H; Gekle M
Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells.
American journal of physiology. Renal physiology 2004;286(4):F774-83.
2004: Hesse Dorothea; Sauvant Christoph; Holzinger Hildegard; Gekle Michael
Apical expression or expression in a non polarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2004;14(3):177-86.
2004: Schwerdt Gerald; Freudinger Ruth; Schuster Claudia; Silbernagl Stefan; Gekle Michael
Inhibition of mitochondria and extracellular acidification enhance achratoxin A-induced apoptosis in renal collecting duct-derived MDCK-C7 cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2004;14(1-2):47-56.
2003: Sauvant Christoph; Holzinger Hildegard; Gekle Michael
Short-term regulation of basolateral organic anion uptake in proximal tubular opossum kidney cells: prostaglandin E2 acts via receptor-mediated activation of protein kinase A.
Journal of the American Society of Nephrology : JASN 2003;14(12):3017-26.
2003: Brindikova Tatyana A; Bourcier Nathalie; Torres Brian; Pchejetski Dimitri; Gekle Michel; Maximov Georgy V; Montminy Valérie; Insel Paul A; Orlov Sergei N; Isenring Paul
Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter.
American journal of physiology. Cell physiology 2003;285(6):C1445-53.
2003: Gekle Michael; Knaus Petra; Nielsen Rikke; Mildenberger Sigrid; Freudinger Ruth; Wohlfarth Verena; Sauvant Christoph; Christensen Erik I
Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells.
The Journal of physiology 2003;552(Pt 2):471-81.
2003: Seefelder W; Humpf H-U; Schwerdt G; Freudinger R; Gekle M
Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites.
Toxicology and applied pharmacology 2003;192(2):146-53.
2003: Krug Alexander W; Grossmann Claudia; Schuster Claudia; Freudinger Ruth; Mildenberger Sigrid; Govindan Manjapra V; Gekle Michael
Aldosterone stimulates epidermal growth factor receptor expression.
The Journal of biological chemistry 2003;278(44):43060-6.
2003: Leicht Monika; Marx Grit; Karbach Doris; Gekle Michael; Köhler Thomas; Zimmer Heinz-Gerd
Mechanism of cell death of rat cardiac fibroblasts induced by serum depletion.
Molecular and cellular biochemistry 2003;251(1-2):119-26.
2003: Krug Alexander W; Papavassiliou Friderun; Hopfer Ulrich; Ullrich Karl J; Gekle Michael
Aldosterone stimulates surface expression of NHE3 in renal proximal brush borders.
Pflügers Archiv : European journal of physiology 2003;446(4):492-6.
2003: Wohlfarth Verena; Drumm Karina; Mildenberger Sigrid; Freudinger Ruth; Gekle Michael
Protein uptake disturbs collagen homeostasis in proximal tubule-derived cells.
Kidney international. Supplement 2003;(84):S103-9.
2003: Schwerdt Gerald; Freudinger Ruth; Schuster Claudia; Silbernagl Stefan; Gekle Michael
Inhibition of mitochondria prevents cell death in kidney epithelial cells by intra- and extracellular acidification.
Kidney international 2003;63(5):1725-35.
2003: Drumm Karina; Lee Erwin; Stanners Scott; Gassner Birgit; Gekle Michael; Poronnik Philip; Pollock Carol
Albumin and glucose effects on cell growth parameters, albumin uptake and Na(+)/H(+)-exchanger Isoform 3 in OK cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2003;13(4):199-206.
2002: Seefelder W; Schwerdt G; Freudinger R; Gekle M; Humpf H-U
Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;780(1):137-44.
2002: Krug Alexander W; Schuster Claudia; Gassner Birgit; Freudinger Ruth; Mildenberger Sigrid; Troppmair Jakob; Gekle Michael
Human epidermal growth factor receptor-1 expression renders Chinese hamster ovary cells sensitive to alternative aldosterone signaling.
The Journal of biological chemistry 2002;277(48):45892-7.
2002: Gekle Michael; Serrano Oscar K; Drumm Karina; Mildenberger Sigrid; Freudinger Ruth; Gassner Birgit; Jansen Hans Willi; Christensen Erik I
NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis.
American journal of physiology. Renal physiology 2002;283(3):F549-58.
2002: Sauvant Christoph; Holzinger Hildegard; Gekle Michael
Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA(2), and COX1.
Journal of the American Society of Nephrology : JASN 2002;13(8):1981-91.
2002: Delles Christian; Schneider Markus P; John Stefan; Gekle Michael; Schmieder Roland E
Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension.
American journal of hypertension 2002;15(7 Pt 1):590-3.
2002: Gekle Michael; Freudinger Ruth; Mildenberger Sigrid; Silbernagl Stefan
Rapid actions of aldosterone on cells from renal epithelium: the possible role of EGF-receptor signaling.
Steroids 2002;67(6):499-504.
2002: Bourcier N; Grygorczyk R; Gekle M; Berthiaume Y; Orlov S N
Purinergic-induced ion current in monolayers of C7-MDCK cells: role of basolateral and apical ion transporters.
The Journal of membrane biology 2002;186(3):131-43.
2002: Gekle Michael; Freudinger Ruth; Mildenberger Sigrid; Silbernagl Stefan
Aldosterone interaction with epidermal growth factor receptor signaling in MDCK cells.
American journal of physiology. Renal physiology 2002;282(4):F669-79.
2002: Drumm Karina; Bauer Boris; Freudinger Ruth; Gekle Michael
Albumin induces NF-kappaB expression in human proximal tubule-derived cells (IHKE-1).
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2002;12(4):187-96.
2001: Drumm K; Gassner B; Silbernagl S; Gekle M
Inhibition of Na superset+/H superset+ exchange decreases albumin-induced NF-kappaB activation in renal proximal tubular cell lines (OK and LLC-PK1 cells).
European journal of medical research 2001;6(10):422-32.
2001: Gekle M; Freudinger R; Mildenberger S; Sauvant C
Determination of basolateral Na(+)/H(+) exchange activity in MDCK cells using a multiwell-multilabel reader.
Analytical biochemistry 2001;296(2):174-8.
2001: Drumm K; Gassner B; Silbernagl S; Gekle M
Albumin in the mg/l-range activates NF-kappaB in renal proximal tubule-derived cell lines via tyrosine kinases and protein kinase C.
European journal of medical research 2001;6(6):247-58.
2001: Sauvant C; Holzinger H; Gekle M
Modulation of the basolateral and apical step of transepithelial organic anion secretion in proximal tubular opossum kidney cells. Acute effects of epidermal growth factor and mitogen-activated protein kinase.
The Journal of biological chemistry 2001;276(18):14695-703.
2001: Gekle M; Freudinger R; Mildenberger S; Schenk K; Marschitz I; Schramek H
Rapid activation of Na+/H+-exchange in MDCK cells by aldosterone involves MAP-kinase ERK1/2.
Pflügers Archiv : European journal of physiology 2001;441(6):781-6.
2001: Gekle M; Freudinger R; Mildenberger S
Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion.
The Journal of physiology 2001;531(Pt 3):619-29.
2000: Zhai X Y; Nielsen R; Birn H; Drumm K; Mildenberger S; Freudinger R; Moestrup S K; Verroust P J; Christensen E I; Gekle M
Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.
Kidney international 2000;58(4):1523-33.
2000: Eder S; Benesic A; Freudinger R; Engert J; Schwerdt G; Drumm K; Gekle M
Nephritogenic ochratoxin A interferes with mitochondrial function and pH homeostasis in immortalized human kidney epithelial cells.
Pflügers Archiv : European journal of physiology 2000;440(4):521-9.
2000: Gekle M; Schwerdt G; Freudinger R; Mildenberger S; Wilflingseder D; Pollack V; Dander M; Schramek H
Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations.
The Journal of pharmacology and experimental therapeutics 2000;293(3):837-44.
2000: Benesic A; Mildenberger S; Gekle M
Nephritogenic ochratoxin A interferes with hormonal signalling in immortalized human kidney epithelial cells.
Pflügers Archiv : European journal of physiology 2000;439(3):278-87.
1999: Orlov S N; Dulin N O; Gagnon F; Gekle M; Douglas J G; Schwartz J H; Hamet P
Purinergic modulation of Na(+),K(+),Cl(-) cotransport and MAP kinases is limited to C11-MDCK cells resembling intercalated cells from collecting ducts.
The Journal of membrane biology 1999;172(3):225-34.
1999: Gekle M; Drumm K; Mildenberger S; Freudinger R; Gassner B; Silbernagl S
Inhibition of Na+-H+ exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum.
The Journal of physiology 1999;520 Pt 3():709-21.
1999: Gekle M; Mildenberger S; Sauvant C; Bednarczyk D; Wright S H; Dantzler W H
Inhibition of initial transport rate of basolateral organic anion carrier in renal PT by BK and phenylephrine.
The American journal of physiology 1999;277(2 Pt 2):F251-6.
1999: Schwerdt G; Freudinger R; Silbernagl S; Gekle M
Ochratoxin A-binding proteins in rat organs and plasma and in different cell lines of the kidney.
Toxicology 1999;135(1):1-10.
1999: Wünsch S; Horrocks P; Gekle M; Lanzer M
Single-cell measurements of ion concentrations within the intracellular parasite.
Parasitology today (Personal ed.) 1999;15(5):198-200.
1999: Schwerdt G; Freudinger R; Mildenberger S; Silbernagl S; Gekle M
The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells.
Cell biology and toxicology 1999;15(6):405-15.
1998: Schwerdt G; Freudinger R; Silbernagl S; Gekle M
Apical uptake of radiolabelled ochratoxin A into Madin-Darby canine kidney cells.
Toxicology 1998;131(2-3):193-202.
1998: Sauvant C; Silbernagl S; Gekle M
Exposure to ochratoxin A impairs organic anion transport in proximal-tubule-derived opossum kidney cells.
The Journal of pharmacology and experimental therapeutics 1998;287(1):13-20.
1998: Gekle M; Gassner B; Freudinger R; Mildenberger S; Silbernagl S; Pfaller W; Schramek H
Characterization of an ochratoxin-A-dedifferentiated and cloned renal epithelial cell line.
Toxicology and applied pharmacology 1998;152(1):282-91.
1998: Gekle M; Silbernagl S; Wünsch S
Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells.
The Journal of physiology 1998;511 ( Pt 1)():255-63.
1998: Dahlmann A; Dantzler W H; Silbernagl S; Gekle M
Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: the nephrotoxin can be reabsorbed in all nephron segments by different mechanisms.
The Journal of pharmacology and experimental therapeutics 1998;286(1):157-62.
1998: Gekle M; Mildenberger S; Freudinger R; Silbernagl S
Long-term protein exposure reduces albumin binding and uptake in proximal tubule-derived opossum kidney cells.
Journal of the American Society of Nephrology : JASN 1998;9(6):960-8.
1998: Wünsch S; Sanchez C P; Gekle M; Grosse-Wortmann L; Wiesner J; Lanzer M
Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in Plasmodium falciparum.
The Journal of cell biology 1998;140(2):335-45.
1998: Gekle M; Sauvant C; Schwerdt G; Silbernagl S
Tubulotoxic mechanisms of ochratoxin A.
Kidney & blood pressure research 1998;21(2-4):277-9.
1997: Schramek H; Wilflingseder D; Pollack V; Freudinger R; Mildenberger S; Gekle M
Ochratoxin A-induced stimulation of extracellular signal-regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1460-8.
1997: Gekle M; Silbernagl S; Oberleithner H
The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells.
The American journal of physiology 1997;273(5 Pt 1):C1673-8.
1997: Kuramochi G; Gekle M; Silbernagl S
Ochratoxin A disturbs pH homeostasis in the kidney: increases in pH and HCO3- in the tubules and vasa recta.
Pflügers Archiv : European journal of physiology 1997;434(4):392-7.
1997: Bahnemann E; Kerling H P; Ensminger S; Schwerdt G; Silbernagl S; Gekle M
Renal transepithelial secretion of ochratoxin A in the non-filtering toad kidney.
Toxicology 1997;120(1):11-7.
1997: Gekle M; Mildenberger S; Freudinger R; Schwerdt G; Silbernagl S
Albumin endocytosis in OK cells: dependence on actin and microtubules and regulation by protein kinases.
The American journal of physiology 1997;272(5 Pt 2):F668-77.
1997: Wünsch S; Sanchez C; Gekle M; Kersting U; Fischer K; Horrocks P; Lanzer M
A method to measure the cytoplasmic pH of single, living Plasmodium falciparum parasites.
Behring Institute Mitteilungen 1997;(99):44-50.
1997: Schwerdt G; Gekle M; Freudinger R; Mildenberger S; Silbernagl S
Apical-to-basolateral transepithelial transport of Ochratoxin A by two subtypes of Madin-Darby canine kidney cells.
Biochimica et biophysica acta 1997;1324(2):191-9.
1997: Zingerle M; Silbernagl S; Gekle M
Reabsorption of the nephrotoxin ochratoxin A along the rat nephron in vivo.
The Journal of pharmacology and experimental therapeutics 1997;280(1):220-4.
1997: Kuramochi G; Gekle M; Silbernagl S
Derangement of pH homeostasis in the renal papilla: ochratoxin A increases pH in vasa recta blood.
Nephron 1997;76(4):472-6.
1996: Schwerdt G; Bauer K; Gekle M; Silbernagl S
Accumulation of ochratoxin A in rat kidney in vivo and in cultivated renal epithelial cells in vitro.
Toxicology 1996;114(3):177-85.
1996: Gekle M; Golenhofen N; Oberleithner H; Silbernagl S
Rapid activation of Na+/H+ exchange by aldosterone in renal epithelial cells requires Ca2+ and stimulation of a plasma membrane proton conductance.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10500-4.
1996: Gekle M; Mildenberger S; Freudinger R; Silbernagl S
Functional characterization of albumin binding to the apical membrane of OK cells.
The American journal of physiology 1996;271(2 Pt 2):F286-91.
1996: Ling H; Vamvakas S; Gekle M; Schaefer L; Teschner M; Schaefer R M; Heidland A
Role of lysosomal cathepsin activities in cell hypertrophy induced by NH4Cl in cultured renal proximal tubule cells.
Journal of the American Society of Nephrology : JASN 1996;7(1):73-80.
1996: Gekle M; Silbernagl S
Renal toxicodynamics of ochratoxin A: a pathophysiological approach.
Kidney & blood pressure research 1996;19(5):225-35.
1995: Gekle M; Pollock C A; Silbernagl S
Time- and concentration-dependent biphasic effect of ochratoxin A on growth of proximal tubular cells in primary culture.
The Journal of pharmacology and experimental therapeutics 1995;275(1):397-404.
1995: Wünsch S; Gekle M; Kersting U; Schuricht B; Oberleithner H
Phenotypically and karyotypically distinct Madin-Darby canine kidney cell clones respond differently to alkaline stress.
Journal of cellular physiology 1995;164(1):164-71.
1995: Gekle M; Mildenberger S; Freudinger R; Silbernagl S
Kinetics of receptor-mediated endocytosis of albumin in cells derived from the proximal tubule of the kidney (opossum kidney cells): influence of Ca2+ and cAMP.
Pflügers Archiv : European journal of physiology 1995;430(3):374-80.
1995: Gekle M; Mildenberger S; Freudinger R; Silbernagl S
Endosomal alkalinization reduces Jmax and Km of albumin receptor-mediated endocytosis in OK cells.
The American journal of physiology 1995;268(5 Pt 2):F899-906.
1995: Gekle M; Silbernagl S
Comparison of the buffer capacity of endocytotic vesicles, lysosomes and cytoplasm in cells derived from the proximal tubule of the kidney (opossum kidney cells).
Pflügers Archiv : European journal of physiology 1995;429(3):452-4.
1994: Gekle M; Mildenberger S; Freudinger R; Silbernagl S
The mycotoxin ochratoxin-A impairs protein uptake in cells derived from the proximal tubule of the kidney (opossum kidney cells).
The Journal of pharmacology and experimental therapeutics 1994;271(1):1-6.
1994: Gekle M; Wünsch S; Oberleithner H; Silbernagl S
Characterization of two MDCK-cell subtypes as a model system to study principal cell and intercalated cell properties.
Pflügers Archiv : European journal of physiology 1994;428(2):157-62.
1994: Gekle M; Vogt R; Oberleithner H; Silbernagl S
The mycotoxin ochratoxin A deranges pH homeostasis in Madin-Darby canine kidney cells.
The Journal of membrane biology 1994;139(3):183-90.
1994: Gekle M; Silbernagl S
The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: toxodynamic and toxokinetic aspects.
Renal physiology and biochemistry 1994;17(1):40-9.
1993: Gekle M; Oberleithner H; Silbernagl S
Ochratoxin A impairs "postproximal" nephron function in vivo and blocks plasma membrane anion conductance in Madin-Darby canine kidney cells in vitro.
Pflügers Archiv : European journal of physiology 1993;425(5-6):401-8.
1993: Gekle M; Silbernagl S
Mechanism of ochratoxin A-induced reduction of glomerular filtration rate in rats.
The Journal of pharmacology and experimental therapeutics 1993;267(1):316-21.
1991: Gekle M; Silbernagl S
On leaking into the lumen, amino acids cross the tubule cells. Secretion of L-citrulline in the isolated-perfused non-filtering kidney of the African clawed toad (Xenopus laevis).
Pflügers Archiv : European journal of physiology 1991;419(5):499-503.
1991: Gekle M; Silbernagl S
Basolateral uptake and tubular metabolism of L-citrulline in the isolated-perfused non-filtering kidney of the African clawed toad (Xenopus laevis).
Pflügers Archiv : European journal of physiology 1991;419(5):492-8.

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