Michael Gelb

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Chennamaneni Naveen Kumar; Arif Jenifer; Buckner Frederick S; Gelb Michael H
Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents.
Surrel Fanny; Jemel Ikram; Boilard Eric; Bollinger James G; Payré Christine; Mounier Carine M; Talvinen Kati A; Laine Veli J O; Nevalainen Timo J; Gelb Michael H; Lambeau Gérard
Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators.
Triggiani Massimo; Giannattasio Giorgio; Calabrese Cecilia; Loffredo Stefania; Granata Francescopaolo; Fiorello Alfonso; Santini Mario; Gelb Michael H; Marone Gianni
Lung mast cells are a source of secreted phospholipases A2.

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All Publications

2009: Chennamaneni Naveen Kumar; Arif Jenifer; Buckner Frederick S; Gelb Michael H
Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents.
Bioorganic & medicinal chemistry letters 2009;19(23):6582-4.
2009: Surrel Fanny; Jemel Ikram; Boilard Eric; Bollinger James G; Payré Christine; Mounier Carine M; Talvinen Kati A; Laine Veli J O; Nevalainen Timo J; Gelb Michael H; Lambeau Gérard
Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators.
Molecular pharmacology 2009;76(4):778-90.
2009: Triggiani Massimo; Giannattasio Giorgio; Calabrese Cecilia; Loffredo Stefania; Granata Francescopaolo; Fiorello Alfonso; Santini Mario; Gelb Michael H; Marone Gianni
Lung mast cells are a source of secreted phospholipases A2.
The Journal of allergy and clinical immunology 2009;124(3):558-65, 565.e1-3.
2009: Suryadevara Praveen Kumar; Olepu Srinivas; Lockman Jeffrey W; Ohkanda Junko; Karimi Mandana; Verlinde Christophe L M J; Kraus James M; Schoepe Jan; Van Voorhis Wesley C; Hamilton Andrew D; Buckner Frederick S; Gelb Michael H
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.
Journal of medicinal chemistry 2009;52(12):3703-15.
2009: Blanchard Sophie; Turecek Frantisek; Gelb Michael H
Short synthetic sequence for 2-sulfation of alpha-L-iduronate glycosides.
Carbohydrate research 2009;344(8):1032-3.
2009: Tucker Dawn E; Ghosh Moumita; Ghomashchi Farideh; Loper Robyn; Suram Saritha; John Bonnie St; Girotti Milena; Bollinger James G; Gelb Michael H; Leslie Christina C
Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function.
The Journal of biological chemistry 2009;284(14):9596-611.
2009: Kraus James M; Verlinde Christophe L M J; Karimi Mandana; Lepesheva Galina I; Gelb Michael H; Buckner Frederick S
Rational modification of a candidate cancer drug for use against Chagas disease.
Journal of medicinal chemistry 2009;52(6):1639-47.
2009: Giannattasio Giorgio; Lai Ying; Granata Francescopaolo; Mounier Carine M; Nallan Laxman; Oslund Rob; Leslie Christina C; Marone Gianni; Lambeau Gérard; Gelb Michael H; Triggiani Massimo
Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis.
Biochimica et biophysica acta 2009;1791(2):92-102.
2008: Blanchard Sophie; Sadilek Martin; Scott C Ronald; Turecek Frantisek; Gelb Michael H
Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis I.
Clinical chemistry 2008;54(12):2067-70.
2008: Oslund Rob C; Cermak Nathan; Verlinde Christophe L M J; Gelb Michael H
Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA.
Bioorganic & medicinal chemistry letters 2008;18(20):5415-9.
2008: Ojo Kayode K; Gillespie J Robert; Riechers Aaron J; Napuli Alberto J; Verlinde Christophe L M J; Buckner Frederick S; Gelb Michael H; Domostoj Mathias M; Wells Susan J; Scheer Alexander; Wells Timothy N C; Van Voorhis Wesley C
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.
Antimicrobial agents and chemotherapy 2008;52(10):3710-7.
2008: Fletcher Steven; Cummings Christopher G; Rivas Kasey; Katt William P; Hornéy Carrie; Buckner Frederick S; Chakrabarti Debopam; Sebti Saïd M; Gelb Michael H; Van Voorhis Wesley C; Hamilton Andrew D
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Journal of medicinal chemistry 2008;51(17):5176-97.
2008: Tucker Dawn E; Gijón Miguel A; Spencer Diane M; Qiu Zhi-Hua; Gelb Michael H; Leslie Christina C
Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages.
Journal of leukocyte biology 2008;84(3):798-806.
2008: Oslund Rob C; Cermak Nathan; Gelb Michael H
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2.
Journal of medicinal chemistry 2008;51(15):4708-14.
2008: Bulbule Vivek J; Rivas Kasey; Verlinde Christophe L M J; Van Voorhis Wesley C; Gelb Michael H
2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability.
Journal of medicinal chemistry 2008;51(3):384-7.
2008: Olepu Srinivas; Suryadevara Praveen Kumar; Rivas Kasey; Yokoyama Kohei; Verlinde Christophe L M J; Chakrabarti Debopam; Van Voorhis Wesley C; Gelb Michael H
2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials.
Bioorganic & medicinal chemistry letters 2008;18(2):494-7.
2008: Yokoyama Kohei; Gillespie John R; Van Voorhis Wesley C; Buckner Frederick S; Gelb Michael H
Protein geranylgeranyltransferase-I of Trypanosoma cruzi.
Molecular and biochemical parasitology 2008;157(1):32-43.
2008: Lambeau Gérard; Gelb Michael H
Biochemistry and physiology of mammalian secreted phospholipases A2.
Annual review of biochemistry 2008;77():495-520.
2007: Hallstrand Teal S; Chi Emil Y; Singer Alan G; Gelb Michael H; Henderson William R
Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness.
American journal of respiratory and critical care medicine 2007;176(11):1072-8.
2007: Van Voorhis Wesley C; Rivas Kasey L; Bendale Pravin; Nallan Laxman; Hornéy Carolyn; Barrett Lynn K; Bauer Kevin D; Smart Brian P; Ankala Sudha; Hucke Oliver; Verlinde Christophe L M J; Chakrabarti Debopam; Strickland Corey; Yokoyama Kohei; Buckner Frederick S; Hamilton Andrew D; Williams David K; Lombardo Louis J; Floyd David; Gelb Michael H
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Antimicrobial agents and chemotherapy 2007;51(10):3659-71.
2007: Bendale Pravin; Olepu Srinivas; Suryadevara Praveen Kumar; Bulbule Vivek; Rivas Kasey; Nallan Laxman; Smart Brian; Yokoyama Kohei; Ankala Sudha; Pendyala Prakash Rao; Floyd David; Lombardo Louis J; Williams David K; Buckner Frederick S; Chakrabarti Debopam; Verlinde Christophe L M J; Van Voorhis Wesley C; Gelb Michael H
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Journal of medicinal chemistry 2007;50(19):4585-605.
2007: Gelb Michael H
Drug discovery for malaria: a very challenging and timely endeavor.
Current opinion in chemical biology 2007;11(4):440-5.
2007: Gillespie John R; Yokoyama Kohei; Lu Karen; Eastman Richard T; Bollinger James G; Van Voorhis Wesley C; Gelb Michael H; Buckner Frederick S
C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins.
Molecular and biochemical parasitology 2007;153(2):115-24.
2007: Henderson William R; Chi Emil Y; Bollinger James G; Tien Ying-tzang; Ye Xin; Castelli Luca; Rubtsov Yuri P; Singer Alan G; Chiang Gertrude K S; Nevalainen Timo; Rudensky Alexander Y; Gelb Michael H
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model.
The Journal of experimental medicine 2007;204(4):865-77.
2007: Ghosh Moumita; Loper Robyn; Ghomashchi Farideh; Tucker Dawn E; Bonventre Joseph V; Gelb Michael H; Leslie Christina C
Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts.
The Journal of biological chemistry 2007;282(16):11676-86.
2007: Eastman Richard T; White John; Hucke Oliver; Yokoyama Kohei; Verlinde Christophe L M J; Hast Michael A; Beese Lorena S; Gelb Michael H; Rathod Pradipsinh K; Van Voorhis Wesley C
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
Molecular and biochemical parasitology 2007;152(1):66-71.
2007: Rouault Morgane; Le Calvez Catherine; Boilard Eric; Surrel Fanny; Singer Alan; Ghomashchi Farideh; Bezzine Sofiane; Scarzello Sabine; Bollinger James; Gelb Michael H; Lambeau Gérard
Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.
Biochemistry 2007;46(6):1647-62.
2007: Wang Ding; Wood Tim; Sadilek Martin; Scott C Ronald; Turecek Frantisek; Gelb Michael H
Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for mucopolysaccharidosis II (Hunter disease).
Clinical chemistry 2007;53(1):137-40.
2007: Lu Yu; Bottari Patricia; Aebersold Ruedi; Turecek Frantisek; Gelb Michael H
Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags.
Methods in molecular biology (Clifton, N.J.) 2007;359():159-76.
2007: Turecek Frantisek; Scott C Ronald; Gelb Michael H
Tandem mass spectrometry in the detection of inborn errors of metabolism for newborn screening.
Methods in molecular biology (Clifton, N.J.) 2007;359():143-57.
2006: Boilard Eric; Rouault Morgane; Surrel Fanny; Le Calvez Catherine; Bezzine Sofiane; Singer Alan; Gelb Michael H; Lambeau Gérard
Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor.
Biochemistry 2006;45(44):13203-18.
2006: Gelb Michael H; Brunsveld Lucas; Hrycyna Christine A; Michaelis Susan; Tamanoi Fuyuhiko; Van Voorhis Wesley C; Waldmann Herbert
Therapeutic intervention based on protein prenylation and associated modifications.
Nature chemical biology 2006;2(10):518-28.
2006: Glenn Matthew P; Chang Sung-Youn; Hornéy Carrie; Rivas Kasey; Yokoyama Kohei; Pusateri Erin E; Fletcher Steven; Cummings Christopher G; Buckner Frederick S; Pendyala Prakash R; Chakrabarti Debopam; Sebti Saïd M; Gelb Michael; Van Voorhis Wesley C; Hamilton Andrew D
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Journal of medicinal chemistry 2006;49(19):5710-27.
2006: Seebacher Jan; Mallick Parag; Zhang Ning; Eddes James S; Aebersold Ruedi; Gelb Michael H
Protein cross-linking analysis using mass spectrometry, isotope-coded cross-linkers, and integrated computational data processing.
Journal of proteome research 2006;5(9):2270-82.
2006: Blacken Grady R; Gelb Michael H; Turecek Frantisek
Metal affinity capture tandem mass spectrometry for the selective detection of phosphopeptides.
Analytical chemistry 2006;78(17):6065-73.
2006: Mehlin Christopher; Boni Erica; Buckner Frederick S; Engel Linnea; Feist Tiffany; Gelb Michael H; Haji Lutfiyah; Kim David; Liu Colleen; Mueller Natascha; Myler Peter J; Reddy J T; Sampson Joshua N; Subramanian E; Van Voorhis Wesley C; Worthey Elizabeth; Zucker Frank; Hol Wim G J
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes.
Molecular and biochemical parasitology 2006;148(2):144-60.
2006: Eerola Leena I; Surrel Fanny; Nevalainen Timo J; Gelb Michael H; Lambeau Gérard; Laine V Jukka O
Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels.
Biochimica et biophysica acta 2006;1761(7):745-56.
2006: Ghosh Moumita; Loper Robyn; Gelb Michael H; Leslie Christina C
Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes.
The Journal of biological chemistry 2006;281(24):16615-24.
2006: Ni Zhanglin; Okeley Nicole M; Smart Brian P; Gelb Michael H
Intracellular actions of group IIA secreted phospholipase A2 and group IVA cytosolic phospholipase A2 contribute to arachidonic acid release and prostaglandin production in rat gastric mucosal cells and transfected human embryonic kidney cells.
The Journal of biological chemistry 2006;281(24):16245-55.
2006: Smart Brian P; Oslund Rob C; Walsh Laura A; Gelb Michael H
The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding.
Journal of medicinal chemistry 2006;49(10):2858-60.
2006: Rouault Morgane; Rash Lachlan D; Escoubas Pierre; Boilard Eric; Bollinger James; Lomonte Bruno; Maurin Thomas; Guillaume Carole; Canaan Stéphane; Deregnaucourt Christiane; Schrével Joseph; Doglio Alain; Gutiérrez José María; Lazdunski Michel; Gelb Michael H; Lambeau Gérard
Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.
Biochemistry 2006;45(18):5800-16.
2006: Gelb Michael H; Turecek Frantisek; Scott C Ron; Chamoles Nestor A
Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders.
Journal of inherited metabolic disease 2006;29(2-3):397-404.
2006: Huhtinen Heikki T; Grönroos Juha O; Grönroos Juha M; Uksila Jaakko; Gelb Michael H; Nevalainen Timo J; Laine V Jukka O
Antibacterial effects of human group IIA and group XIIA phospholipase A2 against Helicobacter pylori in vitro.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2006;114(2):127-30.
2006: Eastman Richard T; Buckner Frederick S; Yokoyama Kohei; Gelb Michael H; Van Voorhis Wesley C
Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation.
Journal of lipid research 2006;47(2):233-40.
2006: Gelb Michael H; Holm Brian P
A simple and inexpensive device for removal of solvent from a large collection of sample tubes.
Journal of combinatorial chemistry 2006;8(1):15-7.
2005: Forsell Pontus K A; Olsson Anders O; Andersson Erik; Nallan Laxman; Gelb Michael H
Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha.
Biochemical pharmacology 2005;71(1-2):144-55.
2005: Mallampalli Monica P; Huyer Gregory; Bendale Pravin; Gelb Michael H; Michaelis Susan
Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(40):14416-21.
2005: Tucker Dawn E; Stewart Allison; Nallan Laxman; Bendale Pravine; Ghomashchi Farideh; Gelb Michael H; Leslie Christina C
Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells.
Journal of lipid research 2005;46(10):2122-33.
2005: Petan Toni; Krizaj Igor; Gelb Michael H; Pungercar Joze
Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A2 enzymes.
Biochemistry 2005;44(37):12535-45.
2005: Toth Julia I; Yang Shao H; Qiao Xin; Beigneux Anne P; Gelb Michael H; Moulson Casey L; Miner Jeffrey H; Young Stephen G; Fong Loren G
Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12873-8.
2005: Buckner Frederick S; Eastman Richard T; Yokoyama Kohei; Gelb Michael H; Van Voorhis Wesley C
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
Current opinion in investigational drugs (London, England : 2000) 2005;6(8):791-7.
2005: Hucke Oliver; Gelb Michael H; Verlinde Christophe L M J; Buckner Frederick S
The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.
Journal of medicinal chemistry 2005;48(17):5415-8.
2005: Glenn Matthew P; Chang Sung-Youn; Hucke Oliver; Verlinde Christophe L M J; Rivas Kasey; Hornéy Carrie; Yokoyama Kohei; Buckner Frederick S; Pendyala Prakash R; Chakrabarti Debopam; Gelb Michael; Van Voorhis Wesley C; Sebti Saïd M; Hamilton Andrew D
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Angewandte Chemie (International ed. in English) 2005;44(31):4903-6.
2005: Yang Shao H; Bergo Martin O; Toth Julia I; Qiao Xin; Hu Yan; Sandoval Salemiz; Meta Margarita; Bendale Pravin; Gelb Michael H; Young Stephen G; Fong Loren G
Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10291-6.
2005: Nallan Laxman; Bauer Kevin D; Bendale Pravin; Rivas Kasey; Yokoyama Kohei; Hornéy Carolyn P; Pendyala Prakash Rao; Floyd David; Lombardo Louis J; Williams David K; Hamilton Andrew; Sebti Said; Windsor William T; Weber Patricia C; Buckner Frederick S; Chakrabarti Debopam; Gelb Michael H; Van Voorhis Wesley C
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Journal of medicinal chemistry 2005;48(11):3704-13.
2005: Nielsen Robert D; Che Kepeng; Gelb Michael H; Robinson Bruce H
A ruler for determining the position of proteins in membranes.
Journal of the American Chemical Society 2005;127(17):6430-42.
2005: Kita Yoshihiro; Takahashi Toshie; Uozumi Naonori; Nallan Laxman; Gelb Michael H; Shimizu Takao
Pathway-oriented profiling of lipid mediators in macrophages.
Biochemical and biophysical research communications 2005;330(3):898-906.
2005: Wang Ding; Eadala Bhramara; Sadilek Martin; Chamoles Nestor A; Turecek Frantisek; Scott C Ronald; Gelb Michael H
Tandem mass spectrometric analysis of dried blood spots for screening of mucopolysaccharidosis I in newborns.
Clinical chemistry 2005;51(5):898-900.
2005: Nevalainen Timo J; Eerola Leena I; Rintala Esa; Laine V Jukka O; Lambeau Gérard; Gelb Michael H
Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum.
Biochimica et biophysica acta 2005;1733(2-3):210-23.
2005: Eastman Richard T; White John; Hucke Oliver; Bauer Kevin; Yokoyama Kohei; Nallan Laxman; Chakrabarti Debopam; Verlinde Christophe L M J; Gelb Michael H; Rathod Pradipsinh K; Van Voorhis Wesley C
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
The Journal of biological chemistry 2005;280(14):13554-9.
2005: Rubin Barry B; Downey Gregory P; Koh Adeline; Degousee Norbert; Ghomashchi Farideh; Nallan Laxman; Stefanski Eva; Harkin Denis W; Sun Chunxiang; Smart Brian P; Lindsay Thomas F; Cherepanov Vera; Vachon Eric; Kelvin David; Sadilek Martin; Brown Glenn E; Yaffe Michael B; Plumb Jonathan; Grinstein Sergio; Glogauer Michael; Gelb Michael H
Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity.
The Journal of biological chemistry 2005;280(9):7519-29.
2005: Haas Ulrike; Podda Maurizio; Behne Martin; Gurrieri Silvia; Alonso Angel; Fürstenberger Gerhard; Pfeilschifter Josef; Lambeau Gérard; Gelb Michael H; Kaszkin Marietta
Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin.
The Journal of investigative dermatology 2005;124(1):204-11.
2005: Granata Francescopaolo; Petraroli Angelica; Boilard Eric; Bezzine Sofiane; Bollinger James; Del Vecchio Luigi; Gelb Michael H; Lambeau Gerard; Marone Gianni; Triggiani Massimo
Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):464-74.
2004: Carrico Dora; Ohkanda Junko; Kendrick Howard; Yokoyama Kohei; Blaskovich Michelle A; Bucher Cynthia J; Buckner Frederick S; Van Voorhis Wesley C; Chakrabarti Debopam; Croft Simon L; Gelb Michael H; Sebti Saïd M; Hamilton Andrew D
In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.
Bioorganic & medicinal chemistry 2004;12(24):6517-26.
2004: Masuda Seiko; Murakami Makoto; Matsumoto Shigeko; Eguchi Naomi; Urade Yoshihiro; Lambeau Gerald; Gelb Michael H; Ishikawa Yukio; Ishii Toshiharu; Kudo Ichiro
Localization of various secretory phospholipase A2 enzymes in male reproductive organs.
Biochimica et biophysica acta 2004;1686(1-2):61-76.
2004: Ivanovski Gabriela; Petan Toni; Krizaj Igor; Gelb Michael H; Gubensek Franc; Pungercar Joze
Basic amino acid residues in the beta-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin A.
Biochimica et biophysica acta 2004;1702(2):217-25.
2004: Bollinger James G; Diraviyam Karthikeyan; Ghomashchi Farideh; Murray Diana; Gelb Michael H
Interfacial binding of bee venom secreted phospholipase A2 to membranes occurs predominantly by a nonelectrostatic mechanism.
Biochemistry 2004;43(42):13293-304.
2004: Sved Paul; Scott Kieran F; McLeod Duncan; King Nicholas J C; Singh Jas; Tsatralis Tania; Nikolov Blagoy; Boulas John; Nallan Laxman; Gelb Michael H; Sajinovic Mila; Graham Garry G; Russell Pamela J; Dong Qihan
Oncogenic action of secreted phospholipase A2 in prostate cancer.
Cancer research 2004;64(19):6934-40.
2004: Li Yijun; Scott C Ronald; Chamoles Nestor A; Ghavami Ahmad; Pinto B Mario; Turecek Frantisek; Gelb Michael H
Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening.
Clinical chemistry 2004;50(10):1785-96.
2004: Lu Yu; Bottari Patricia; Turecek Frantisek; Aebersold Ruedi; Gelb Michael H
Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags.
Analytical chemistry 2004;76(14):4104-11.
2004: Nielsen Robert D; Canaan Stephane; Gladden James A; Gelb Michael H; Mailer Colin; Robinson Bruce H
Comparing continuous wave progressive saturation EPR and time domain saturation recovery EPR over the entire motional range of nitroxide spin labels.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;169(1):129-63.
2004: Mounier Carine M; Ghomashchi Farideh; Lindsay Margaret R; James Scott; Singer Alan G; Parton Robert G; Gelb Michael H
Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha.
The Journal of biological chemistry 2004;279(24):25024-38.
2004: Okeley Nicole M; Gelb Michael H
A designed probe for acidic phospholipids reveals the unique enriched anionic character of the cytosolic face of the mammalian plasma membrane.
The Journal of biological chemistry 2004;279(21):21833-40.
2004: Smart Brian P; Pan Ying H; Weeks Amanda K; Bollinger James G; Bahnson Brian J; Gelb Michael H
Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues: a structure-guided study.
Bioorganic & medicinal chemistry 2004;12(7):1737-49.
2004: Canaan Stéphane; Zádori Zoltán; Ghomashchi Farideh; Bollinger James; Sadilek Martin; Moreau Marie Eve; Tijssen Peter; Gelb Michael H
Interfacial enzymology of parvovirus phospholipases A2.
The Journal of biological chemistry 2004;279(15):14502-8.
2004: Bottari Patricia; Aebersold Ruedi; Turecek Frantisek; Gelb Michael H
Design and synthesis of visible isotope-coded affinity tags for the absolute quantification of specific proteins in complex mixtures.
Bioconjugate chemistry 2004;15(2):380-8.
2004: Li Yijun; Brockmann Knut; Turecek Frantisek; Scott C Ronald; Gelb Michael H
Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for Krabbe disease.
Clinical chemistry 2004;50(3):638-40.
2004: Triggiani M; Giannattasio G; Balestrieri B; Granata F; Gelb M H; de Paulis A; Marone G
Differential modulation of mediator release from human basophils and mast cells by mizolastine.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(2):241-9.
2004: Ohkanda Junko; Buckner Frederick S; Lockman Jeffrey W; Yokoyama Kohei; Carrico Dora; Eastman Richard; de Luca-Fradley Kate; Davies Wendy; Croft Simon L; Van Voorhis Wesley C; Gelb Michael H; Sebti Saïd M; Hamilton Andrew D
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Journal of medicinal chemistry 2004;47(2):432-45.
2004: Leslie Christina C; Gelb Michael H
Assaying phospholipase A2 activity.
Methods in molecular biology (Clifton, N.J.) 2004;284():229-42.
2003: Buckner Frederick; Yokoyama Kohei; Lockman Jeffrey; Aikenhead Kendra; Ohkanda Junko; Sadilek Martin; Sebti Said; Van Voorhis Wesley; Hamilton Andrew; Gelb Michael H
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15149-53.
2003: Rouault Morgane; Bollinger James G; Lazdunski Michel; Gelb Michael H; Lambeau Gérard
Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity.
Biochemistry 2003;42(39):11494-503.
2003: Beck Sabine; Lambeau Gérard; Scholz-Pedretti Kristen; Gelb Michael H; Janssen Marcel J W; Edwards Suzanne H; Wilton David C; Pfeilschifter Josef; Kaszkin Marietta
Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.
The Journal of biological chemistry 2003;278(32):29799-812.
2003: Gurrieri Silvia; Fürstenberger Gerhard; Schadow Alexia; Haas Ulrike; Singer Alan G; Ghomashchi Farideh; Pfeilschifter Josef; Lambeau Gérard; Gelb Michael H; Kaszkin Marietta
Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis.
The Journal of investigative dermatology 2003;121(1):156-64.
2003: Beers Stephen A; Buckland Andrew G; Giles Niroshini; Gelb Michael H; Wilton David C
Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2.
Biochemistry 2003;42(24):7326-38.
2003: Ferri Nicola; Yokoyama Kohei; Sadilek Martin; Paoletti Rodolfo; Apitz-Castro Rafael; Gelb Michael H; Corsini Alberto
Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation.
British journal of pharmacology 2003;138(5):811-8.
2003: Murakami Makoto; Masuda Seiko; Shimbara Satoko; Bezzine Sofiane; Lazdunski Michael; Lambeau Gérald; Gelb Michael H; Matsukura Satoshi; Kokubu Fumio; Adachi Mitsuru; Kudo Ichiro
Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).
The Journal of biological chemistry 2003;278(12):10657-67.
2003: Gelb Michael H; Van Voorhis Wesley C; Buckner Frederick S; Yokoyama Kohei; Eastman Richard; Carpenter Elisabeth P; Panethymitaki Chrysoula; Brown Katherine A; Smith Deborah F
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.
Molecular and biochemical parasitology 2003;126(2):155-63.
2003: Li Yijun; Ogata Yuko; Freeze Hudson H; Scott C Ronald; Turecek Frantisek; Gelb Michael H
Affinity capture and elution/electrospray ionization mass spectrometry assay of phosphomannomutase and phosphomannose isomerase for the multiplex analysis of congenital disorders of glycosylation types Ia and Ib.
Analytical chemistry 2003;75(1):42-8.
2002: Singer Alan G; Ghomashchi Farideh; Le Calvez Catherine; Bollinger James; Bezzine Sofiane; Rouault Morgane; Sadilek Martin; Nguyen Eric; Lazdunski Michel; Lambeau Gerard; Gelb Michael H
Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.
The Journal of biological chemistry 2002;277(50):48535-49.
2002: Bezzine Sofiane; Bollinger James G; Singer Alan G; Veatch Sarah L; Keller Sarah L; Gelb Michael H
On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids.
The Journal of biological chemistry 2002;277(50):48523-34.
2002: Choe Jungwoo; Suresh Stephen; Wisedchaisri Goragot; Kennedy Kevin J; Gelb Michael H; Hol Wim G J
Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase.
Chemistry & biology 2002;9(11):1189-97.
2002: Kuksa Vladimir; Bartl Franz; Maeda Tadao; Jang Geeng-Fu; Ritter Eglof; Heck Martin; Van Hooser J Preston; Liang Yan; Filipek Slawomir; Gelb Michael H; Hofmann Klaus Peter; Palczewski Krzysztof
Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals.
The Journal of biological chemistry 2002;277(44):42315-24.
2002: Ogata Yuko; Scampavia Louis; Ruzicka Jaromír; Scott C Ronald; Gelb Michael H; Turecek Frantisek
Automated affinity capture-release of biotin-containing conjugates using a lab-on-valve apparatus coupled to UV/visible and electrospray ionization mass spectrometry.
Analytical chemistry 2002;74(18):4702-8.
2002: Pan Ying H; Yu Bao-Zhu; Singer Alan G; Ghomashchi Farideh; Lambeau Gerard; Gelb Michael H; Jain Mahendra K; Bahnson Brian J
Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.
The Journal of biological chemistry 2002;277(32):29086-93.
2002: Canaan Stéphane; Nielsen Robert; Ghomashchi Farideh; Robinson Bruce H; Gelb Michael H
Unusual mode of binding of human group IIA secreted phospholipase A2 to anionic interfaces as studied by continuous wave and time domain electron paramagnetic resonance spectroscopy.
The Journal of biological chemistry 2002;277(34):30984-90.
2002: Gelb Michael H; Hol Wim G J
Parasitology. Drugs to combat tropical protozoan parasites.
Science (New York, N.Y.) 2002;297(5580):343-4.
2002: Murakami Makoto; Yoshihara Kumiko; Shimbara Satoko; Lambeau Gerald; Gelb Michael H; Singer Alan G; Sawada Masatsugu; Inagaki Naoki; Nagai Hiroichi; Ishihara Motoko; Ishikawa Yukio; Ishii Toshiharu; Kudo Ichiro
Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2.
The Journal of biological chemistry 2002;277(21):19145-55.
2002: Murakami Makoto; Yoshihara Kumiko; Shimbara Satoko; Lambeau Gerard; Singer Alan; Gelb Michael H; Sawada Masatsugu; Inagaki Naoki; Nagai Hiroichi; Kudo Ichiro
Arachidonate release and eicosanoid generation by group IIE phospholipase A(2).
Biochemical and biophysical research communications 2002;292(3):689-96.
2002: Degousee Norbert; Ghomashchi Farideh; Stefanski Eva; Singer Alan; Smart Brian P; Borregaard Niels; Reithmeier Reinhardt; Lindsay Thomas F; Lichtenberger Cornelia; Reinisch Walter; Lambeau Gerard; Arm Jonathan; Tischfield Jay; Gelb Michael H; Rubin Barry B
Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.
The Journal of biological chemistry 2002;277(7):5061-73.
2002: Koduri Rao S; Grönroos Juha O; Laine Veli J O; Le Calvez Catherine; Lambeau Gérard; Nevalainen Timo J; Gelb Michael H
Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2).
The Journal of biological chemistry 2002;277(8):5849-57.
2002: Beers Stephen A; Buckland Andrew G; Koduri Rao S; Cho Wonhwa; Gelb Michael H; Wilton David C
The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the enzyme to allow penetration of the bacterial cell wall.
The Journal of biological chemistry 2002;277(3):1788-93.
2001: Ferri N; Arnaboldi L; Orlandi A; Yokoyama K; Gree R; Granata A; Hachem A; Paoletti R; Gelb M H; Corsini A
Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation.
Biochemical pharmacology 2001;62(12):1637-45.
2001: Ghomashchi F; Stewart A; Hefner Y; Ramanadham S; Turk J; Leslie C C; Gelb M H
A pyrrolidine-based specific inhibitor of cytosolic phospholipase A(2)alpha blocks arachidonic acid release in a variety of mammalian cells.
Biochimica et biophysica acta 2001;1513(2):160-6.
2001: Gerber S A; Turecek F; Gelb M H
Design and synthesis of substrate and internal standard conjugates for profiling enzyme activity in the Sanfilippo syndrome by affinity chromatography/electrospray ionization mass spectrometry.
Bioconjugate chemistry 2001;12(4):603-15.
2001: Jang G F; Kuksa V; Filipek S; Bartl F; Ritter E; Gelb M H; Hofmann K P; Palczewski K
Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein.
The Journal of biological chemistry 2001;276(28):26148-53.
2001: Bressi J C; Verlinde C L; Aronov A M; Shaw M L; Shin S S; Nguyen L N; Suresh S; Buckner F S; Van Voorhis W C; Kuntz I D; Hol W G; Gelb M H
Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.
Journal of medicinal chemistry 2001;44(13):2080-93.
2001: Suresh S; Bressi J C; Kennedy K J; Verlinde C L; Gelb M H; Hol W G
Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors.
Journal of molecular biology 2001;309(2):423-35.
2001: Zhou X; Turecek F; Scott C R; Gelb M H
Quantification of cellular acid sphingomyelinase and galactocerebroside beta-galactosidase activities by electrospray ionization mass spectrometry.
Clinical chemistry 2001;47(5):874-81.
2001: Gerber S A; Scott C R; Turecek F; Gelb M H
Direct profiling of multiple enzyme activities in human cell lysates by affinity chromatography/electrospray ionization mass spectrometry: application to clinical enzymology.
Analytical chemistry 2001;73(8):1651-7.
2001: Ohkanda J; Lockman J W; Yokoyama K; Gelb M H; Croft S L; Kendrick H; Harrell M I; Feagin J E; Blaskovich M A; Sebti S M; Hamilton A D
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.
Bioorganic & medicinal chemistry letters 2001;11(6):761-4.
2001: Murakami M; Koduri R S; Enomoto A; Shimbara S; Seki M; Yoshihara K; Singer A; Valentin E; Ghomashchi F; Lambeau G; Gelb M H; Kudo I
Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms.
The Journal of biological chemistry 2001;276(13):10083-96.
2001: Verlinde C L; Hannaert V; Blonski C; Willson M; Périé J J; Fothergill-Gilmore L A; Opperdoes F R; Gelb M H; Hol W G; Michels P A
Glycolysis as a target for the design of new anti-trypanosome drugs.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2001;4(1):50-65.
2001: Cook T A; Ghomashchi F; Gelb M H; Florio S K; Beavo J A
The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP hydrolysis in rod outer segments.
The Journal of biological chemistry 2001;276(7):5248-55.
2001: Kennedy K J; Bressi J C; Gelb M H
A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase.
Bioorganic & medicinal chemistry letters 2001;11(2):95-8.
2001: Schadow A; Scholz-Pedretti K; Lambeau G; Gelb M H; Fürstenberger G; Pfeilschifter J; Kaszkin M
Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA.
The Journal of investigative dermatology 2001;116(1):31-9.
2000: Valentin E; Singer A G; Ghomashchi F; Lazdunski M; Gelb M H; Lambeau G
Cloning and recombinant expression of human group IIF-secreted phospholipase A(2).
Biochemical and biophysical research communications 2000;279(1):223-8.
2000: Gelb M H; Valentin E; Ghomashchi F; Lazdunski M; Lambeau G
Cloning and recombinant expression of a structurally novel human secreted phospholipase A2.
The Journal of biological chemistry 2000;275(51):39823-6.
2000: Hefner Y; Borsch-Haubold A G; Murakami M; Wilde J I; Pasquet S; Schieltz D; Ghomashchi F; Yates J R; Armstrong C G; Paterson A; Cohen P; Fukunaga R; Hunter T; Kudo I; Watson S P; Gelb M H
Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.
The Journal of biological chemistry 2000;275(48):37542-51.
2000: Bressi J C; Choe J; Hough M T; Buckner F S; Van Voorhis W C; Verlinde C L; Hol W G; Gelb M H
Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.
Journal of medicinal chemistry 2000;43(22):4135-50.
2000: Cook T A; Ghomashchi F; Gelb M H; Florio S K; Beavo J A
Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits.
Biochemistry 2000;39(44):13516-23.
2000: Gelb M H; Min J H; Jain M K
Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes.
Biochimica et biophysica acta 2000;1488(1-2):20-7.
2000: Enomoto A; Murakami M; Valentin E; Lambeau G; Gelb M H; Kudo I
Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):4007-14.
2000: Gelb M H; Kudo I
[Phospholipase A2 inhibitor]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):1065-71.
2000: Valentin E; Ghomashchi F; Gelb M H; Lazdunski M; Lambeau G
Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme.
The Journal of biological chemistry 2000;275(11):7492-6.
2000: Bezzine S; Koduri R S; Valentin E; Murakami M; Kudo I; Ghomashchi F; Sadilek M; Lambeau G; Gelb M H
Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells.
The Journal of biological chemistry 2000;275(5):3179-91.
2000: Whitten M E; Yokoyama K; Schieltz D; Ghomashchi F; Lam D; Yates J R; Palczewski K; Gelb M H
Structural analysis of protein prenyl groups and associated C-terminal modifications.
Methods in enzymology 2000;316():436-51.
1999: Valentin E; Ghomashchi F; Gelb M H; Lazdunski M; Lambeau G
On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes.
The Journal of biological chemistry 1999;274(44):31195-202.
1999: Gygi S P; Rist B; Gerber S A; Turecek F; Gelb M H; Aebersold R
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags.
Nature biotechnology 1999;17(10):994-9.
1999: Gelb M H; Cho W; Wilton D C
Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan.
Current opinion in structural biology 1999;9(4):428-32.
1999: Ghomashchi F; Loo R; Balsinde J; Bartoli F; Apitz-Castro R; Clark J D; Dennis E A; Gelb M H
Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A(2): structure-function studies with vesicle, micelle, and membrane assays.
Biochimica et biophysica acta 1999;1420(1-2):45-56.
1999: Zhao X; Yokoyama K; Whitten M E; Huang J; Gelb M H; Palczewski K
A novel form of rhodopsin kinase from chicken retina and pineal gland.
FEBS letters 1999;454(1-2):115-21.
1999: Valentin E; Koduri R S; Scimeca J C; Carle G; Gelb M H; Lazdunski M; Lambeau G
Cloning and recombinant expression of a novel mouse-secreted phospholipase A2.
The Journal of biological chemistry 1999;274(27):19152-60.
1999: Ball A; Nielsen R; Gelb M H; Robinson B H
Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6637-42.
1999: Bryant M D; Flick K E; Koduri R S; Wilton D C; Stoddard B L; Gelb M H
1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A: X-ray structure of the complex and interfacial selection of inhibitors from a structural library.
Bioorganic & medicinal chemistry letters 1999;9(8):1097-102.
1999: Han S K; Kim K P; Koduri R; Bittova L; Munoz N M; Leff A R; Wilton D C; Gelb M H; Cho W
Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2.
The Journal of biological chemistry 1999;274(17):11881-8.
1999: Aronov A M; Suresh S; Buckner F S; Van Voorhis W C; Verlinde C L; Opperdoes F R; Hol W G; Gelb M H
Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4273-8.
1999: Stecher H; Gelb M H; Saari J C; Palczewski K
Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein.
The Journal of biological chemistry 1999;274(13):8577-85.
1999: Dudler T; Gelb M H
Probing the role of H-Ras lipidation for signaling functions in Xenopus laevis oocytes.
Methods in molecular biology (Clifton, N.J.) 1999;116():161-76.
1999: Corsini A; Farnsworth C C; McGeady P; Gelb M H; Glomset J A
Incorporation of radiolabeled prenyl alcohols and their analogs into mammalian cell proteins. A useful tool for studying protein prenylation.
Methods in molecular biology (Clifton, N.J.) 1999;116():125-44.
1998: Aronov A M; Gelb M H
Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8.
Bioorganic & medicinal chemistry letters 1998;8(24):3505-10.
1998: Koduri R S; Baker S F; Snitko Y; Han S K; Cho W; Wilton D C; Gelb M H
Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme.
The Journal of biological chemistry 1998;273(48):32142-53.
1998: Aronov A M; Verlinde C L; Hol W G; Gelb M H
Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.
Journal of medicinal chemistry 1998;41(24):4790-9.
1998: Yokoyama K; Trobridge P; Buckner F S; Van Voorhis W C; Stuart K D; Gelb M H
Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics.
The Journal of biological chemistry 1998;273(41):26497-505.
1998: Lin Y; Ghomashchi F; Nielsen R; Snitko Y; Yu B Z; Han S K; Cho W; Wilton D C; Jain M K; Robinson B H; Gelb M H
Binding of bee venom and human group IIa phospholipases A2 to membranes: a minor role for electrostatics.
Biochemical Society transactions 1998;26(3):341-5.
1998: Yokoyama K; Trobridge P; Buckner F S; Scholten J; Stuart K D; Van Voorhis W C; Gelb M H
The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth.
Molecular and biochemical parasitology 1998;94(1):87-97.
1998: Bernstein B E; Williams D M; Bressi J C; Kuhn P; Gelb M H; Blackburn G M; Hol W G
A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei.
Journal of molecular biology 1998;279(5):1137-48.
1998: Hixon M S; Ball A; Gelb M H
Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2.
Biochemistry 1998;37(23):8516-26.
1998: Lee K C; Lukyanov A N; Gelb M H; Yager P
Formation of high axial ratio microstructures from peptides modified with glutamic acid dialkyl amides.
Biochimica et biophysica acta 1998;1371(2):168-84.
1998: Ghomashchi F; Lin Y; Hixon M S; Yu B Z; Annand R; Jain M K; Gelb M H
Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis.
Biochemistry 1998;37(19):6697-710.
1998: Jang G F; Gelb M H
Substrate specificity of mammalian prenyl protein-specific endoprotease activity.
Biochemistry 1998;37(13):4473-81.
1998: Lin Y; Nielsen R; Murray D; Hubbell W L; Mailer C; Robinson B H; Gelb M H
Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance.
Science (New York, N.Y.) 1998;279(5358):1925-9.
1998: Gelb M H; Scholten J D; Sebolt-Leopold J S
Protein prenylation: from discovery to prospects for cancer treatment.
Current opinion in chemical biology 1998;2(1):40-8.
1998: Börsch-Haubold A G; Bartoli F; Asselin J; Dudler T; Kramer R M; Apitz-Castro R; Watson S P; Gelb M H
Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.
The Journal of biological chemistry 1998;273(8):4449-58.
1997: Snitko Y; Koduri R S; Han S K; Othman R; Baker S F; Molini B J; Wilton D C; Gelb M H; Cho W
Mapping the interfacial binding surface of human secretory group IIa phospholipase A2.
Biochemistry 1997;36(47):14325-33.
1997: Dudler T; Gelb M H
Replacement of the H-Ras farnesyl group by lipid analogues: implications for downstream processing and effector activation in Xenopus oocytes.
Biochemistry 1997;36(41):12434-41.
1997: Yokoyama K; Lin Y; Stuart K D; Gelb M H
Prenylation of proteins in Trypanosoma brucei.
Molecular and biochemical parasitology 1997;87(1):61-9.
1997: Carlson P A; Gelb M H; Yager P
Zero-order interfacial enzymatic degradation of phospholipid tubules.
Biophysical journal 1997;73(1):230-8.
1997: Raiteri M; Arnaboldi L; McGeady P; Gelb M H; Verri D; Tagliabue C; Quarato P; Ferraboschi P; Santaniello E; Paoletti R; Fumagalli R; Corsini A
Pharmacological control of the mevalonate pathway: effect on arterial smooth muscle cell proliferation.
The Journal of pharmacology and experimental therapeutics 1997;281(3):1144-53.
1997: Yu B Z; Ghomashchi F; Cajal Y; Annand R R; Berg O G; Gelb M H; Jain M K
Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2.
Biochemistry 1997;36(13):3870-81.
1997: Schneider T; Dudler T; Annand R R; Gelb M H; King T P; Suter M
Comparison of the antibody response to bee venom phospholipase A2 induced by natural exposure in humans or by immunization in mice.
Journal of molecular recognition : JMR 1997;10(2):93-100.
1997: Gelb M H
Protein prenylation, et cetera: signal transduction in two dimensions.
Science (New York, N.Y.) 1997;275(5307):1750-1.
1997: Bayburt T; Gelb M H
Interfacial catalysis by human 85 kDa cytosolic phospholipase A2 on anionic vesicles in the scooting mode.
Biochemistry 1997;36(11):3216-31.
1997: Nicolas J P; Lin Y; Lambeau G; Ghomashchi F; Lazdunski M; Gelb M H
Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity.
The Journal of biological chemistry 1997;272(11):7173-81.
1997: Yokoyama K; Zimmerman K; Scholten J; Gelb M H
Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation.
The Journal of biological chemistry 1997;272(7):3944-52.
1996: Liu L; Dudler T; Gelb M H
Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide.
The Journal of biological chemistry 1996;271(38):23269-76.
1996: Dudler T; Gelb M H
Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes.
The Journal of biological chemistry 1996;271(19):11541-7.
1996: Annand R R; Kontoyianni M; Penzotti J E; Dudler T; Lybrand T P; Gelb M H
Active site of bee venom phospholipase A2: the role of histidine-34, aspartate-64 and tyrosine-87.
Biochemistry 1996;35(14):4591-601.
1996: de Carvalho M G; McCormack A L; Olson E; Ghomashchi F; Gelb M H; Yates J R; Leslie C C
Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes.
The Journal of biological chemistry 1996;271(12):6987-97.
1995: Bayburt T; Yu B Z; Street I; Ghomashchi F; Laliberté F; Perrier H; Wang Z; Homan R; Jain M K; Gelb M H
Continuous, vesicle-based fluorimetric assays of 14- and 85-kDa phospholipases A2.
Analytical biochemistry 1995;232(1):7-23.
1995: McGeady P; Kuroda S; Shimizu K; Takai Y; Gelb M H
The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase.
The Journal of biological chemistry 1995;270(44):26347-51.
1995: Ghomashchi F; Zhang X; Liu L; Gelb M H
Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange.
Biochemistry 1995;34(37):11910-8.
1995: Dudler T; Machado D C; Kolbe L; Annand R R; Rhodes N; Gelb M H; Koelsch K; Suter M; Helm B A
A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2605-13.
1995: Glover S; de Carvalho M S; Bayburt T; Jonas M; Chi E; Leslie C C; Gelb M H
Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen.
The Journal of biological chemistry 1995;270(25):15359-67.
1995: Hanel A M; Gelb M H
Multiple enzymatic activities of the human cytosolic 85-kDa phospholipase A2: hydrolytic reactions and acyl transfer to glycerol.
Biochemistry 1995;34(24):7807-18.
1995: Yokoyama K; McGeady P; Gelb M H
Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling.
Biochemistry 1995;34(4):1344-54.
1995: Jain M K; Gelb M H; Rogers J; Berg O G
Kinetic basis for interfacial catalysis by phospholipase A2.
Methods in enzymology 1995;249():567-614.
1995: Liu L; Jang G F; Farnsworth C C; Yokoyama K; Glomset J A; Gelb M H
Synthetic prenylated peptides: studying prenyl protein-specific endoprotease and other aspects of protein prenylation.
Methods in enzymology 1995;250():189-206.
1995: Gelb M H; Jain M K; Hanel A M; Berg O G
Interfacial enzymology of glycerolipid hydrolases: lessons from secreted phospholipases A2.
Annual review of biochemistry 1995;64():653-88.
1994: Farnsworth C C; Seabra M C; Ericsson L H; Gelb M H; Glomset J A
Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11963-7.
1994: Schneider T; Dudler T; Gelb M H; Suter M
Lysine residues in bee venom phospholipase A2 are important for binding to human monoclonal or polyclonal antibodies of the IgG4 isotope.
International archives of allergy and immunology 1994;104(3):262-9.
1994: Bartoli F; Lin H K; Ghomashchi F; Gelb M H; Jain M K; Apitz-Castro R
Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets.
The Journal of biological chemistry 1994;269(22):15625-30.
1994: Dudler T; Schneider T; Annand R R; Gelb M H; Suter M
Antigenic surface of the bee venom allergen phospholipase A2. Structural functional analysis of human IgG4 antibodies reveals potential role in protection.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5514-22.
1994: Jain M K; Krause C D; Buckley J T; Bayburt T; Gelb M H
Characterization of interfacial catalysis by Aeromonas hydrophila lipase/acyltransferase in the highly processive scooting mode.
Biochemistry 1994;33(17):5011-20.
1993: Jang G F; Yokoyama K; Gelb M H
A prenylated protein-specific endoprotease in rat liver microsomes that produces a carboxyl-terminal tripeptide.
Biochemistry 1993;32(36):9500-7.
1993: Hanel A M; Schüttel S; Gelb M H
Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A2 enzymes on product-containing vesicles: application to the determination of substrate preferences.
Biochemistry 1993;32(23):5949-58.
1993: Street I P; Lin H K; Laliberté F; Ghomashchi F; Wang Z; Perrier H; Tremblay N M; Huang Z; Weech P K; Gelb M H
Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2.
Biochemistry 1993;32(23):5935-40.
1993: Yokoyama K; Gelb M H
Purification of a mammalian protein geranylgeranyltransferase. Formation and catalytic properties of an enzyme-geranylgeranyl pyrophosphate complex.
The Journal of biological chemistry 1993;268(6):4055-60.
1993: Bayburt T; Yu B Z; Lin H K; Browning J; Jain M K; Gelb M H
Human nonpancreatic secreted phospholipase A2: interfacial parameters, substrate specificities, and competitive inhibitors.
Biochemistry 1993;32(2):573-82.
1992: Dudler T; Chen W Q; Wang S; Schneider T; Annand R R; Dempcy R O; Crameri R; Gmachl M; Suter M; Gelb M H
High-level expression in Escherichia coli and rapid purification of enzymatically active honey bee venom phospholipase A2.
Biochimica et biophysica acta 1992;1165(2):201-10.
1992: Jain M K; Yu B Z; Rogers J; Gelb M H; Tsai M D; Hendrickson E K; Hendrickson H S
Interfacial catalysis by phospholipase A2: the rate-limiting step for enzymatic turnover.
Biochemistry 1992;31(34):7841-7.
1992: Yokoyama K; Goodwin G W; Ghomashchi F; Glomset J; Gelb M H
Protein prenyltransferases.
Biochemical Society transactions 1992;20(2):489-94.
1992: Glomset J A; Gelb M H; Farnsworth C C
Geranylgeranylated proteins.
Biochemical Society transactions 1992;20(2):479-84.
1992: Ghomashchi F; Schüttel S; Jain M K; Gelb M H
Kinetic analysis of a high molecular weight phospholipase A2 from rat kidney: divalent metal-dependent trapping of enzyme on product-containing vesicles.
Biochemistry 1992;31(15):3814-24.
1991: Ghomashchi F; Yu B Z; Mihelich E D; Jain M K; Gelb M H
Kinetic characterization of phospholipase A2 modified by manoalogue.
Biochemistry 1991;30(40):9559-69.
1991: Farnsworth C C; Kawata M; Yoshida Y; Takai Y; Gelb M H; Glomset J A
C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6196-200.
1991: Jain M K; Rogers J; Berg O; Gelb M H
Interfacial catalysis by phospholipase A2: activation by substrate replenishment.
Biochemistry 1991;30(29):7340-8.
1991: Ghomashchi F; Yu B Z; Berg O; Jain M K; Gelb M H
Interfacial catalysis by phospholipase A2: substrate specificity in vesicles.
Biochemistry 1991;30(29):7318-29.
1991: Ghomashchi F; O'Hare T; Clary D; Gelb M H
Interfacial catalysis by phospholipase A2: evaluation of the interfacial rate constants by steady-state isotope effect studies.
Biochemistry 1991;30(29):7298-305.
1991: Yokoyama K; Goodwin G W; Ghomashchi F; Glomset J A; Gelb M H
A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5302-6.
1991: Finegold A A; Johnson D I; Farnsworth C C; Gelb M H; Judd S R; Glomset J A; Tamanoi F
Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4448-52.
1991: Yamane H K; Farnsworth C C; Xie H Y; Evans T; Howald W N; Gelb M H; Glomset J A; Clarke S; Fung B K
Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):286-90.
1990: Goodman L E; Judd S R; Farnsworth C C; Powers S; Gelb M H; Glomset J A; Tamanoi F
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9665-9.
1990: Kawata M; Farnsworth C C; Yoshida Y; Gelb M H; Glomset J A; Takai Y
Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8960-4.
1990: Yamane H K; Farnsworth C C; Xie H Y; Howald W; Fung B K; Clarke S; Gelb M H; Glomset J A
Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5868-72.
1990: Yuan W; Quinn D M; Sigler P B; Gelb M H
Kinetic and inhibition studies of phospholipase A2 with short-chain substrates and inhibitors.
Biochemistry 1990;29(25):6082-94.
1990: Glomset J A; Gelb M H; Farnsworth C C
Prenyl proteins in eukaryotic cells: a new type of membrane anchor.
Trends in biochemical sciences 1990;15(4):139-42.
1990: Farnsworth C C; Gelb M H; Glomset J A
Identification of geranylgeranyl-modified proteins in HeLa cells.
Science (New York, N.Y.) 1990;247(4940):320-2.
1989: Farnsworth C C; Wolda S L; Gelb M H; Glomset J A
Human lamin B contains a farnesylated cysteine residue.
The Journal of biological chemistry 1989;264(34):20422-9.
1989: Jain M K; Yuan W; Gelb M H
Competitive inhibition of phospholipase A2 in vesicles.
Biochemistry 1989;28(10):4135-9.
1988: Lin Y K; Myhrman R; Schrag M L; Gelb M H
Bacterial N-succinyl-L-diaminopimelic acid desuccinylase. Purification, partial characterization, and substrate specificity.
The Journal of biological chemistry 1988;263(4):1622-7.

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