Harris Gelbard

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Eggert Dawn; Dash Prasanta K; Serradji Nawal; Dong Chang-Zhi; Clayette Pascal; Heymans Francoise; Dou Huanyu; Gorantla Santhi; Gelbard Harris A; Poluektova Larisa; Gendelman Howard E
Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders.
Schifitto Giovanni; Zhong Jianhui; Gill David; Peterson Derick R; Gaugh Michelle D; Zhu Tong; Tivarus Madalina; Cruttenden Kim; Maggirwar Sanjay B; Gendelman Howard E; Dewhurst Stephen; Gelbard Harris A
Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.
Norman John P; Perry Seth W; Reynolds Holly M; Kiebala Michelle; De Mesy Bentley Karen L; Trejo Margarita; Volsky David J; Maggirwar Sanjay B; Dewhurst Stephen; Masliah Eliezer; Gelbard Harris A
HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

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2009: Eggert Dawn; Dash Prasanta K; Serradji Nawal; Dong Chang-Zhi; Clayette Pascal; Heymans Francoise; Dou Huanyu; Gorantla Santhi; Gelbard Harris A; Poluektova Larisa; Gendelman Howard E
Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders.
Journal of neuroimmunology 2009;213(1-2):47-59.
2009: Schifitto Giovanni; Zhong Jianhui; Gill David; Peterson Derick R; Gaugh Michelle D; Zhu Tong; Tivarus Madalina; Cruttenden Kim; Maggirwar Sanjay B; Gendelman Howard E; Dewhurst Stephen; Gelbard Harris A
Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.
Journal of neurovirology 2009;15(2):176-86.
2008: Norman John P; Perry Seth W; Reynolds Holly M; Kiebala Michelle; De Mesy Bentley Karen L; Trejo Margarita; Volsky David J; Maggirwar Sanjay B; Dewhurst Stephen; Masliah Eliezer; Gelbard Harris A
HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.
PloS one 2008;3(11):e3731.
2007: Lu Shao-Ming; Tong Ning; Gelbard Harris A
The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2007;2(2):194-201.
2007: Dewhurst Stephen; Maggirwar Sanjay B; Schifitto Giovanni; Gendelman Howard E; Gelbard Harris A
Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2007;2(1):93-6.
2007: Sui Ziye; Sniderhan Lynn F; Schifitto Giovanni; Phipps Richard P; Gelbard Harris A; Dewhurst Stephen; Maggirwar Sanjay B
Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3226-36.
2007: Norman John P; Perry Seth W; Kasischke Karl A; Volsky David J; Gelbard Harris A
HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):869-76.
2006: Sui Ziye; Fan Shongshan; Sniderhan Lynn; Reisinger Elizabeth; Litzburg Angela; Schifitto Giovanni; Gelbard Harris A; Dewhurst Stephen; Maggirwar Sanjay B
Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):702-11.
2006: Sui Ziye; Sniderhan Lynn F; Fan Shongshan; Kazmierczak Katarzyna; Reisinger Elizabeth; Kovács Attila D; Potash Mary Jane; Dewhurst Stephen; Gelbard Harris A; Maggirwar Sanjay B
Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons.
The European journal of neuroscience 2006;23(10):2623-34.
2006: Bellizzi Matthew J; Lu Shao-Ming; Gelbard Harris A
Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2006;1(1):20-31.
2006: Schifitto G; Peterson D R; Zhong J; Ni H; Cruttenden K; Gaugh M; Gendelman H E; Boska M; Gelbard H
Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report.
Neurology 2006;66(6):919-21.
2005: Bellizzi Matthew J; Lu Shao-Ming; Masliah Eliezer; Gelbard Harris A
Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor.
The Journal of clinical investigation 2005;115(11):3185-92.
2005: Perry S W; Norman J P; Gelbard H A
Adjunctive therapies for HIV-1 associated neurologic disease.
Neurotoxicity research 2005;8(1-2):161-6.
2005: Dou Huanyu; Ellison Brent; Bradley Jennifer; Kasiyanov Alexander; Poluektova Larisa Y; Xiong Huangui; Maggirwar Sanjay; Dewhurst Stephen; Gelbard Harris A; Gendelman Howard E
Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(37):8375-85.
2005: Nelson J A; Dou H; Ellison B; Uberti M; Xiong H; Anderson E; Mellon M; Gelbard H A; Boska M; Gendelman H E
Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis.
Journal of neuroscience research 2005;80(4):562-75.
2005: Perry Seth W; Norman John P; Litzburg Angela; Zhang Dabao; Dewhurst Stephen; Gelbard Harris A
HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4333-44.
2004: Nitkiewicz Jadwiga; Chao Wei; Bentsman Galina; Li Jinliang; Kim Seon-Young; Choi So Young; Grunig Gabrielle; Gelbard Harris; Potash Mary Jane; Volsky David J
Productive infection of primary murine astrocytes, lymphocytes, and macrophages by human immunodeficiency virus type 1 in culture.
Journal of neurovirology 2004;10(6):400-8.
2004: DiCenzo Robert; Peterson Derick; Cruttenden Kim; Morse Gene; Riggs Garret; Gelbard Harris; Schifitto Giovanni
Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults.
Antimicrobial agents and chemotherapy 2004;48(11):4328-31.
2004: Perry Seth W; Norman John P; Litzburg Angela; Gelbard Harris A
Antioxidants are required during the early critical period, but not later, for neuronal survival.
Journal of neuroscience research 2004;78(4):485-92.
2004: Ramirez Servio H; Fan Shongshan; Maguire Casey A; Perry Seth; Hardiek Kathy; Ramkumar Vickram; Gelbard Harris A; Dewhurst Stephen; Maggirwar Sanjay B
Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal.
Journal of neuroscience research 2004;77(2):258-69.
2004: Latchney Lisa R; Fallon Margaret A; Culp David J; Gelbard Harris A; Dewhurst Stephen
Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(5):671-81.
2004: Guo Huang; Liu Dong; Gelbard Harris; Cheng Tong; Insalaco Rae; Fernández José A; Griffin John H; Zlokovic Berislav V
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3.
Neuron 2004;41(4):563-72.
2004: Gelbard Harris A
Synapses and Sisyphus: life without paraplegin.
The Journal of clinical investigation 2004;113(2):185-7.
2004: Dou Huanyu; Kingsley Jeffrey D; Mosley R Lee; Gelbard Harris A; Gendelman Howard E
Neuroprotective strategies for HIV-1 associated dementia.
Neurotoxicity research 2004;6(7-8):503-21.
2004: Wang Zhuying; Trillo-Pazos Gusta; Kim Seon-Young; Canki Mario; Morgello Susan; Sharer Leroy R; Gelbard Harris A; Su Zao-Zhong; Kang Dong-Chul; Brooks Andrew I; Fisher Paul B; Volsky David J
Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis.
Journal of neurovirology 2004;10 Suppl 1():25-32.
2003: Dou Huanyu; Birusingh Kevin; Faraci Jill; Gorantla Santhi; Poluektova Larisa Y; Maggirwar Sanjay B; Dewhurst Stephen; Gelbard Harris A; Gendelman Howard E
Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(27):9162-70.
2003: Wang Zhuying; Pekarskaya Olga; Bencheikh Meryem; Chao Wei; Gelbard Harris A; Ghorpade Anuja; Rothstein Jeffrey D; Volsky David J
Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120.
Virology 2003;312(1):60-73.
2002: Perry Seth W; Dewhurst Stephen; Bellizzi Matthew J; Gelbard Harris A
Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?
Journal of neurovirology 2002;8(6):611-24.
2002: Diesing Thomas S; Swindells Susan; Gelbard Harris; Gendelman Howard E
HIV-1-associated dementia: a basic science and clinical perspective.
The AIDS reader 2002;12(8):358-68.
2001: Ramirez S H; Sanchez J F; Dimitri C A; Gelbard H A; Dewhurst S; Maggirwar S B
Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism.
Journal of neurochemistry 2001;78(4):874-89.
2001: Tong N; Sanchez J F; Maggirwar S B; Ramirez S H; Guo H; Dewhurst S; Gelbard H A
Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons.
The European journal of neuroscience 2001;13(10):1913-22.
2001: Zhu Y; Gelbard H A; Roshal M; Pursell S; Jamieson B D; Planelles V
Comparison of cell cycle arrest, transactivation, and apoptosis induced by the simian immunodeficiency virus SIVagm and human immunodeficiency virus type 1 vpr genes.
Journal of virology 2001;75(8):3791-801.
2000: Guo H; Tong N; Turner T; Epstein L G; McDermott M P; Kilgannon P; Gelbard H A
Release of the neuronal glycoprotein ICAM-5 in serum after hypoxic-ischemic injury.
Annals of neurology 2000;48(4):590-602.
2000: Maggirwar S B; Ramirez S; Tong N; Gelbard H A; Dewhurst S
Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cells.
Journal of neurochemistry 2000;74(2):527-39.
2000: Tong N; Perry S W; Zhang Q; James H J; Guo H; Brooks A; Bal H; Kinnear S A; Fine S; Epstein L G; Dairaghi D; Schall T J; Gendelman H E; Dewhurst S; Sharer L R; Gelbard H A
Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1333-9.
1999: James H J; Sharer L R; Zhang Q; Wang H G; Epstein L G; Reed J C; Gelbard H A
Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis.
Neuropathology and applied neurobiology 1999;25(5):380-6.
1999: Zheng J; Thylin M R; Ghorpade A; Xiong H; Persidsky Y; Cotter R; Niemann D; Che M; Zeng Y C; Gelbard H A; Shepard R B; Swartz J M; Gendelman H E
Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia.
Journal of neuroimmunology 1999;98(2):185-200.
1999: Maggirwar S B; Tong N; Ramirez S; Gelbard H A; Dewhurst S
HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity.
Journal of neurochemistry 1999;73(2):578-86.
1999: Epstein L G; Gelbard H A
HIV-1-induced neuronal injury in the developing brain.
Journal of leukocyte biology 1999;65(4):453-7.
1999: Fine S M; Maggirwar S B; Elliott P R; Epstein L G; Gelbard H A; Dewhurst S
Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia.
Journal of neuroimmunology 1999;95(1-2):55-64.
1999: Brooks A I; Chadwick C A; Gelbard H A; Cory-Slechta D A; Federoff H J
Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.
Brain research 1999;823(1-2):1-10.
1999: Gelbard H A
Neuroprotective strategies for HIV-1-associated neurologic disease.
Annals of the New York Academy of Sciences 1999;890():312-3.
1998: Hodge S; Novembre F J; Whetter L; Gelbard H A; Dewhurst S
Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14.
Virology 1998;252(2):354-63.
1998: Deng S X; Panahian N; James H; Gelbard H A; Federoff H J; Dewhurst S; Epstein L G
Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption.
Journal of neuroscience methods 1998;83(2):159-64.
1998: New D R; Maggirwar S B; Epstein L G; Dewhurst S; Gelbard H A
HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.
The Journal of biological chemistry 1998;273(28):17852-8.
1998: Perry S W; Hamilton J A; Tjoelker L W; Dbaibo G; Dzenko K A; Epstein L G; Hannun Y; Whittaker J S; Dewhurst S; Gelbard H A
Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis.
The Journal of biological chemistry 1998;273(28):17660-4.
1997: Krajewski S; James H J; Ross J; Blumberg B M; Epstein L G; Gendelman H E; Gummuluru S; Dewhurst S; Sharer L R; Reed J C; Gelbard H A
Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis.
Neuropathology and applied neurobiology 1997;23(3):242-53.
1997: Perry S W; Epstein L G; Gelbard H A
Simultaneous in situ detection of apoptosis and necrosis in monolayer cultures by TUNEL and trypan blue staining.
BioTechniques 1997;22(6):1102-6.
1997: Perry S W; Epstein L G; Gelbard H A
In situ trypan blue staining of monolayer cell cultures for permanent fixation and mounting.
BioTechniques 1997;22(6):1020-1, 1024.
1997: New D R; Ma M; Epstein L G; Nath A; Gelbard H A
Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures.
Journal of neurovirology 1997;3(2):168-73.
1997: Canki M; Potash M J; Bentsman G; Chao W; Flynn T; Heinemann M; Gelbard H; Volsky D J
Isolation and long-term culture of primary ocular human immunodeficiency virus type 1 isolates in primary astrocytes.
Journal of neurovirology 1997;3(1):10-5.
1996: Gummuluru S; Novembre F J; Lewis M; Gelbard H A; Dewhurst S
Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques acutely infected by a highly enteropathic simian immunodeficiency virus, SIVsmmPBj14.
Virology 1996;225(1):21-32.
1996: Persidsky Y; Limoges J; McComb R; Bock P; Baldwin T; Tyor W; Patil A; Nottet H S; Epstein L; Gelbard H; Flanagan E; Reinhard J; Pirruccello S J; Gendelman H E
Human immunodeficiency virus encephalitis in SCID mice.
The American journal of pathology 1996;149(3):1027-53.
1996: Sharer L R; Saito Y; Da Cunha A; Ung P C; Gelbard H A; Epstein L G; Blumberg B M
In situ amplification and detection of HIV-1 DNA in fixed pediatric AIDS brain tissue.
Human pathology 1996;27(6):614-7.
1996: Fine S M; Angel R A; Perry S W; Epstein L G; Rothstein J D; Dewhurst S; Gelbard H A
Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia.
The Journal of biological chemistry 1996;271(26):15303-6.
1996: Nottet H S; Flanagan E M; Flanagan C R; Gelbard H A; Gendelman H E; Reinhard J F
The regulation of quinolinic acid in human immunodeficiency virus-infected monocytes.
Journal of neurovirology 1996;2(2):111-7.
1996: Dewhurst S; Gelbard H A; Fine S M
Neuropathogenesis of AIDS.
Molecular medicine today 1996;2(1):16-23.
1995: Dollard S C; James H J; Sharer L R; Epstein L G; Gelbard H A; Dewhurst S
Activation of nuclear factor kappa B in brains from children with HIV-1 encephalitis.
Neuropathology and applied neurobiology 1995;21(6):518-28.
1995: Gelbard H A; James H J; Sharer L R; Perry S W; Saito Y; Kazee A M; Blumberg B M; Epstein L G
Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy.
Neuropathology and applied neurobiology 1995;21(3):208-17.
1995: Talley A K; Dewhurst S; Perry S W; Dollard S C; Gummuluru S; Fine S M; New D; Epstein L G; Gendelman H E; Gelbard H A
Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA.
Molecular and cellular biology 1995;15(5):2359-66.
1994: Gelbard H A; Nottet H S; Swindells S; Jett M; Dzenko K A; Genis P; White R; Wang L; Choi Y B; Zhang D
Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin.
Journal of virology 1994;68(7):4628-35.
1994: Blumberg B M; Gelbard H A; Epstein L G
HIV-1 infection of the developing nervous system: central role of astrocytes in pathogenesis.
Virus research 1994;32(2):253-67.
1994: Gelbard H A; Applegate C D
Persistent increases in dopamine D2 receptor mRNA expression in basal ganglia following kindling.
Epilepsy research 1994;17(1):23-9.
1993: Gelbard H A; Dzenko K A; DiLoreto D; del Cerro C; del Cerro M; Epstein L G
Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis.
Developmental neuroscience 1993;15(6):417-22.
1992: Genis P; Jett M; Bernton E W; Boyle T; Gelbard H A; Dzenko K; Keane R W; Resnick L; Mizrachi Y; Volsky D J
Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease.
The Journal of experimental medicine 1992;176(6):1703-18.
1991: Kieburtz K D; Epstein L G; Gelbard H A; Greenamyre J T
Excitotoxicity and dopaminergic dysfunction in the acquired immunodeficiency syndrome dementia complex. Therapeutic implications.
Archives of neurology 1991;48(12):1281-4.

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Harris Gelbard

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