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Christof Geldmacher

Research Profile

Disorders

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Tanzania

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HIV Seropositivity

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Publications

TOP 3
Christof Geldmacher; Alimuddin Zumla; Michael Hoelscher
Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis.
Christof Geldmacher; Richard A Koup
Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection.
Alexandra Schuetz; Urban Sester; Jan Dirks; Nyanda Elias; Christof Geldmacher; Antelmo Haule; Michael Hoelscher; Leonard Maboko; Andreas Meyerhans; Klaus Reither; Erica Sanga; Martina Sester
Pathogen prevalence may determine maintenance of antigen-specific T-cell responses in HIV-infected individuals.

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2012: Christof Geldmacher; Alimuddin Zumla; Michael Hoelscher
Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis.
Current opinion in HIV and AIDS 2012;7(3):268-75.
2012: Christof Geldmacher; Richard A Koup
Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection.
Trends in immunology 2012;33(5):207-14.
2012: Alexandra Schuetz; Urban Sester; Jan Dirks; Nyanda Elias; Christof Geldmacher; Antelmo Haule; Michael Hoelscher; Leonard Maboko; Andreas Meyerhans; Klaus Reither; Erica Sanga; Martina Sester
Pathogen prevalence may determine maintenance of antigen-specific T-cell responses in HIV-infected individuals.
AIDS (London, England) 2012;26(6):695-700.
2012: Inge Kroidl; Leonard Maboko; Harun Machibya; Lucas Maganga; Wolfram Mwalongo; Petra Clowes; Christof Geldmacher; Michael Hoelscher; Arne L Kroidl; Elmar Saathoff
Low specificity of determine HIV1/2 RDT using whole blood in south west Tanzania.
PloS one 2012;7(6):e39529.
2011: Steffen Geis; Christof Geldmacher; Deborah L Birx; Oliver Hoffmann; Leonard Maboko; Nelson L Michael; Donan Mmbando; Merlin L Robb; Elmar Saathoff; Eleuter Samky; Michael Hoelscher
Risk factors for HIV-1 infection in a longitudinal, prospective cohort of adults from the Mbeya Region, Tanzania.
Journal of acquired immune deficiency syndromes (1999) 2011;56(5):453-9.
2011: Alexandra Schuetz; Antelmo Haule; Michael Hoelscher; Richard A Koup; Leonard Maboko; Andreas Meyerhans; Njabulo Ngwenyama; Andrea Rachow; Klaus Reither; Christof Geldmacher
Monitoring CD27 expression to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo.
PloS one 2011;6(11):e27284.
2010: Christof Geldmacher; Njabulo Ngwenyama; Alexandra Schuetz; Constantinos Petrovas; Klaus Reither; Edwin J Heeregrave; Joseph P Casazza; David R Ambrozak; Mark Louder; William Ampofo; Georgios Pollakis; Brenna Hill; Erica Sanga; Elmar Saathoff; Leonard Maboko; Mario Roederer; William A Paxton; Michael Hoelscher; Richard A Koup
Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection.
The Journal of experimental medicine 2010;207(13):2869-81.
2009: Christof Geldmacher; Ian S Metzler; Sodsai Tovanabutra; Tedi E Asher; Emma Gostick; David R Ambrozak; Constantinos Petrovas; Alexandra Schuetz; Njabulo Ngwenyama; Gustavo Kijak; Leonard Maboko; Michael Hoelscher; Francine McCutchan; David A Price; Daniel C Douek; Richard A Koup
Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response.
Blood 2009;114(8):1553-62.
2008: Christof Geldmacher; Alexandra Schuetz; Njabulo Ngwenyama; Joseph P Casazza; Erica Sanga; Elmar Saathoff; Catharina Boehme; Steffen Geis; Leonard Maboko; Mahavir Singh; Fred Minja; Andreas Meyerhans; Richard A Koup; Michael Hoelscher
Early depletion of Mycobacterium tuberculosis-specific T helper 1 cell responses after HIV-1 infection.
The Journal of infectious diseases 2008;198(11):1590-8.
2007: Christof Geldmacher; Clive Gray; Martha Nason; Jeffrey R Currier; Antelmo Haule; Lilian Njovu; Steffen Geis; Oliver Hoffmann; Leonard Maboko; Andreas Meyerhans; Josephine Cox; Michael Hoelscher
A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection.
Journal of virology 2007;81(24):13809-15.
2007: Constantinos Petrovas; David A Price; Joseph J Mattapallil; David R Ambrozak; Christof Geldmacher; Valentina Cecchinato; Monica Vaccari; Elzbieta Tryniszewska; Emma Gostick; Mario Roederer; Daniel C Douek; Sara H Morgan; Simon J Davis; Genoveffa Franchini; Richard A Koup
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Blood 2007;110(3):928-36.
2007: Christof Geldmacher; Jeffrey R Currier; Eva Herrmann; Antelmo Haule; Ellen Kuta; Francine E McCutchan; Lilian Njovu; Steffen Geis; Oliver Hoffmann; Leonard Maboko; Carolyn Williamson; Deborah L Birx; Andreas Meyerhans; Josephine Cox; Michael Hoelscher
CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients.
Journal of virology 2007;81(5):2440-8.
2007: Christof Geldmacher; Jeffrey R Currier; Martina Gerhardt; Antelmo Haule; Leonard Maboko; Deborah L Birx; Clive Gray; Andreas Meyerhans; Josephine Cox; Michael Hoelscher
In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype.
AIDS (London, England) 2007;21(2):135-43.