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Harald Genth

Research Profile

Chemicals & Drugs

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Glycosylation

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Anatomy

NIH 3T3 Cells

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Publications

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Martin May; Micro Müller; Tianbang Wang; Harald Genth
Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470.
Johannes Huelsenbeck; Ingo Just; Martin May; Natalia Ronkina; Ilona Schelle; Florian Schulz; Gerhard Fritz; Ralf Gerhard; Martin Hohenegger; Harald Genth
Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.
Jacqueline Rotsch; Ilona Schelle; Harald Genth; Sandra Hagemann; Ingo Just; Tanja Kolbe; Martin May; Astrid Rohrbeck; Stefanie C Huelsenbeck
Inhibition of macrophage migration by C. botulinum exoenzyme C3.

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All Publications

2013: Martin May; Micro Müller; Tianbang Wang; Harald Genth
Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470.
Toxins 2013;5(1):106-19.
2012: Johannes Huelsenbeck; Ingo Just; Martin May; Natalia Ronkina; Ilona Schelle; Florian Schulz; Gerhard Fritz; Ralf Gerhard; Martin Hohenegger; Harald Genth
Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.
FEBS letters 2012;586(20):3665-73.
2012: Jacqueline Rotsch; Ilona Schelle; Harald Genth; Sandra Hagemann; Ingo Just; Tanja Kolbe; Martin May; Astrid Rohrbeck; Stefanie C Huelsenbeck
Inhibition of macrophage migration by C. botulinum exoenzyme C3.
Naunyn-Schmiedeberg's archives of pharmacology 2012;385(9):883-90.
2012: Astrid Rohrbeck; Tanja Kolbe; Harald Genth; Sandra Hagemann; Ingo Just
Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q.
The FEBS journal 2012;279(15):2657-71.
2012: Martin May; Gudula Schmidt; Tianbang Wang; Tanja Kolbe; Harald Genth
Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis.
Journal of signal transduction 2012;2012():570183.
2012: Vanessa Brandes; Sophie Brinkmann; Ralf Gerhard; Ilona Schelle; Florian Schulz; Janett Schwarz; Harald Genth
Protection from Clostridium difficile toxin B-catalysed Rac1/Cdc42 glucosylation by tauroursodeoxycholic acid-induced Rac1/Cdc42 phosphorylation.
Biological chemistry 2012;393(1-2):77-84.
2011: Harald Genth; Ingo Just
Functional implications of lethal toxin-catalysed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease.
European journal of cell biology 2011;90(11):959-65.
2011: Marta Lica; Florian Schulz; Ilona Schelle; Martin May; Ingo Just; Harald Genth
Difference in the biological effects of Clostridium difficile toxin B in proliferating and non-proliferating cells.
Naunyn-Schmiedeberg's archives of pharmacology 2011;383(3):275-83.
2010: Jessica Thalmann; Katrin Janik; Martin May; Kirsten Sommer; Jenny Ebeling; Fred Hofmann; Harald Genth; Andreas Klos
Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac.
PloS one 2010;5(3):e9887.
2009: Stefanie C Huelsenbeck; Martin May; Gudula Schmidt; Harald Genth
Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors--reinforcing the critical role of RhoA in cytokinesis.
Cell motility and the cytoskeleton 2009;66(11):967-75.
2009: Stefanie C Huelsenbeck; Ilona Klose; Maria Reichenbach; Johannes Huelsenbeck; Harald Genth
Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin.
FEBS letters 2009;583(19):3133-9.
2009: Florian Schulz; Ingo Just; Harald Genth
Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid.
Biochemistry 2009;48(38):9002-10.
2009: Stefanie C Dreger; Florian Schulz; Johannes Huelsenbeck; Ralf Gerhard; Fred Hofmann; Ingo Just; Harald Genth
Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling.
Biochemistry 2009;48(8):1785-92.
2008: Ismael Halabi-Cabezon; Johannes Huelsenbeck; Martin May; Markus Ladwein; Klemens Rottner; Ingo Just; Harald Genth
Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1.
FEBS letters 2008;582(27):3751-6.
2008: Harald Genth; Stefanie C Dreger; Johannes Huelsenbeck; Ingo Just
Clostridium difficile toxins: more than mere inhibitors of Rho proteins.
The international journal of biochemistry & cell biology 2008;40(4):592-7.
2007: Stefanie Nottrott; Janett Schoentaube; Harald Genth; Ingo Just; Ralf Gerhard
Clostridium difficile toxin A-induced apoptosis is p53-independent but depends on glucosylation of Rho GTPases.
Apoptosis : an international journal on programmed cell death 2007;12(8):1443-53.
2007: Sabine Conrad; Harald Genth; Franz Hofmann; Ingo Just; Thomas Skutella
Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC.
The Journal of biological chemistry 2007;282(22):16423-33.
2007: Johannes Huelsenbeck; Stefanie C Dreger; Ralf Gerhard; Gerhard Fritz; Ingo Just; Harald Genth
Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile.
Biochemistry 2007;46(16):4923-31.
2007: Johannes Huelsenbeck; Stefanie Dreger; Ralf Gerhard; Holger Barth; Ingo Just; Harald Genth
Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470.
Infection and immunity 2007;75(2):801-9.
2006: Harald Genth; Johannes Huelsenbeck; Birgit Hartmann; Franz Hofmann; Ingo Just; Ralf Gerhard
Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B.
FEBS letters 2006;580(14):3565-9.
2005: Niklas Czeloth; Günter Bernhardt; Franz Hofmann; Harald Genth; Reinhold Förster
Sphingosine-1-phosphate mediates migration of mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2960-7.
2005: Ralf Gerhard; Silke Burger; Helma Tatge; Harald Genth; Ingo Just; Franz Hofmann
Comparison of wild type with recombinant Clostridium difficile toxin A.
Microbial pathogenesis 2005;38(2-3):77-83.
2005: Ralf Gerhard; Helma Tatge; Harald Genth; Thomas Thum; Jürgen Borlak; Gerhard Fritz; Ingo Just
Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.
The Journal of biological chemistry 2005;280(2):1499-505.
2003: Silke Burger; Helma Tatge; Franz Hofmann; Harald Genth; Ingo Just; Ralf Gerhard
Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system.
Biochemical and biophysical research communications 2003;307(3):584-8.
2003: Harald Genth; Ralf Gerhard; Akio Maeda; Mutsuki Amano; Kozo Kaibuchi; Klaus Aktories; Ingo Just
Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex.
The Journal of biological chemistry 2003;278(31):28523-7.
2003: Harald Genth; Martina Schmidt; Ralf Gerhard; Klaus Aktories; Ingo Just
Activation of phospholipase D1 by ADP-ribosylated RhoA.
Biochemical and biophysical research communications 2003;302(1):127-32.
2001: Ingo Just; Franz Hofmann; Harald Genth; Ralf Gerhard
Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins.
International journal of medical microbiology : IJMM 2001;291(4):243-50.
2000: Christian Wilde; Harald Genth; Klaus Aktories; Ingo Just
Recognition of RhoA by Clostridium botulinum C3 exoenzyme.
The Journal of biological chemistry 2000;275(22):16478-83.
2000: Harald Genth; J Selzer; Christian Busch; J Dumbach; Franz Hofmann; Klaus Aktories; Ingo Just
New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization.
Infection and immunity 2000;68(3):1094-101.
1999: Harald Genth; Klaus Aktories; Ingo Just
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling.
The Journal of biological chemistry 1999;274(41):29050-6.
1998: Peter Sehr; G Joseph; Harald Genth; Ingo Just; E Pick; Klaus Aktories
Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling.
Biochemistry 1998;37(15):5296-304.
1996: Harald Genth; Franz Hofmann; J Selzer; G Rex; Klaus Aktories; Ingo Just
Difference in protein substrate specificity between hemorrhagic toxin and lethal toxin from Clostridium sordellii.
Biochemical and biophysical research communications 1996;229(2):370-4.