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Luca Gentilucci

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TOP 3
Rossella De Marco; Santi Spampinato; Alessandra Tolomelli; Andrea Bedini; Luca Gentilucci
Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus.
Rossella De Marco; Pasqualina Rubini; Alessandra Tolomelli; Marilena Campitiello; Luca Gentilucci
Expedient synthesis of pseudo-Pro-containing peptides: towards constrained peptidomimetics and foldamers.
Luca Gentilucci; Alessandra Tolomelli; R De Marco; Roberto Artali
Molecular docking of opiates and opioid peptides, a tool for the design of selective agonists and antagonists, and for the investigation of atypical ligand-receptor interactions.

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All Publications

2012: Rossella De Marco; Santi Spampinato; Alessandra Tolomelli; Andrea Bedini; Luca Gentilucci
Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus.
Journal of medicinal chemistry 2012;55(22):10292-6.
2012: Rossella De Marco; Pasqualina Rubini; Alessandra Tolomelli; Marilena Campitiello; Luca Gentilucci
Expedient synthesis of pseudo-Pro-containing peptides: towards constrained peptidomimetics and foldamers.
Organic & biomolecular chemistry 2012;10(11):2307-17.
2012: Luca Gentilucci; Alessandra Tolomelli; R De Marco; Roberto Artali
Molecular docking of opiates and opioid peptides, a tool for the design of selective agonists and antagonists, and for the investigation of atypical ligand-receptor interactions.
Current medicinal chemistry 2012;19(11):1587-601.
2011: Alessandra Tolomelli; Angelo Viola; Monica Baiula; Laura Belvisi; Samantha Deianira Dattoli; Luca Gentilucci; Elisa Mosconi; santi spampinato; Monica Civera
Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands.
ChemMedChem 2011;6(12):2264-72.
2011: Luca Gentilucci; santi spampinato; Alessandra Tolomelli; Andrea Bedini; Rossella De Marco; Roberto Artali
The inverse type II β-turn on D-Trp-Phe, a pharmacophoric motif for MOR agonists.
ChemMedChem 2011;6(9):1640-53.
2010: Andrea Bedini; Monica Baiula; Luca Gentilucci; Alessandra Tolomelli; Rossella De Marco; santi spampinato
Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model.
Peptides 2010;31(11):2135-40.
2010: Luca Gentilucci; Giuliana Cardillo; santi spampinato; Alessandra Tolomelli; Federico Squassabia; Rossella De Marco; Andrea Bedini; Monica Baiula; Laura Belvisi; Monica Civera
Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics.
Journal of medicinal chemistry 2010;53(1):106-18.
2010: Luca Gentilucci; Rossella De Marco; Lucia Cerisoli
Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization.
Current pharmaceutical design 2010;16(28):3185-203.
2009: Luca Gentilucci; Giuliana Cardillo; Alessandra Tolomelli; Federico Squassabia; Rossella De Marco; Gianpaolo Chiriano
Cyclopeptide analogs for generating new molecular and 3D diversity.
Combinatorial chemistry & high throughput screening 2009;12(10):929-39.
2009: Luca Gentilucci; Giuliana Cardillo; Alessandra Tolomelli; Rossella De Marco; Andrea Garelli; santi spampinato; Antonino Spartà; Eusebio Juaristi
Synthesis and conformational analysis of cyclotetrapeptide mimetic beta-turn templates and validation as 3D scaffolds.
ChemMedChem 2009;4(4):517-23.
2007: Fides Benfatti; Giuliana Cardillo; Serena Fabbroni; Patrizia Galzerano; Luca Gentilucci; Riccardo Juris; Alessandra Tolomelli; Monica Baiula; Antonino Spartà; santi spampinato
Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds.
Bioorganic & medicinal chemistry 2007;15(23):7380-90.
2007: Luca Gentilucci; Giuliana Cardillo; Federico Squassabia; Alessandra Tolomelli; santi spampinato; Antonino Sparta; Monica Baiula
Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics.
Bioorganic & medicinal chemistry letters 2007;17(8):2329-33.
2007: Fides Benfatti; Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli
Synthesis and biological evaluation of unprecedented classes of spiro-beta-lactams and azido-beta-lactams as acyl-CoA:cholesterol acyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(7):1946-50.
2007: Luca Gentilucci; Alessandra Tolomelli; Federico Squassabia
Topological exploration of cyclic endomorphin-1 analogues, structurally defined models for investigating the bioactive conformation of MOR agonists.
Protein and peptide letters 2007;14(1):51-6.
2007: Luca Gentilucci; Federico Squassabia; Roberto Artali
Re-discussion of the importance of ionic interactions in stabilizing ligand-opioid receptor complex and in activating signal transduction.
Current drug targets 2007;8(1):185-96.
2006: Fides Benfatti; Giuliana Cardillo; Luca Gentilucci; Rossana Perciaccante; Alessandra Tolomelli; Alberico Catapano
Synthesis and biological evaluation of azido- and aziridino-hydroxyl-beta-lactams through stereo- and regioselective epoxide ring opening.
The Journal of organic chemistry 2006;71(24):9229-32.
2006: Luca Gentilucci; Giuliana Cardillo; Alessandra Tolomelli; Federico Squassabia; Cristina Tiozzo
A novel family of minimal PMRI cyclic peptides as versatile scaffolds for generating new molecular topology.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2006;2(4):395-400.
2006: Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli
Unusual amino acids: synthesis and introduction into naturally occurring peptides and biologically active analogues.
Mini reviews in medicinal chemistry 2006;6(3):293-304.
2006: Luca Gentilucci; Alessandra Tolomelli; Federico Squassabia
Peptides and peptidomimetics in medicine, surgery and biotechnology.
Current medicinal chemistry 2006;13(20):2449-66.
2005: Giuliana Cardillo; Serena Fabbroni; Luca Gentilucci; Rossana Perciaccante; Fabio Piccinelli; Alessandra Tolomelli
Highly diastereoselective allylic azide formation and isomerization. Synthesis of 3(2'-amino)-beta-lactams.
Organic letters 2005;7(4):533-6.
2004: Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli; Raffaella Spinosa; Maria Calienni; Ahmed Qasem; santi spampinato
Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].
Journal of medicinal chemistry 2004;47(21):5198-203.
2004: Luca Gentilucci; Alessandra Tolomelli
Recent advances in the investigation of the bioactive conformation of peptides active at the micro-opioid receptor. conformational analysis of endomorphins.
Current topics in medicinal chemistry 2004;4(1):105-21.
2004: Luca Gentilucci
New trends in the development of opioid peptide analogues as advanced remedies for pain relief.
Current topics in medicinal chemistry 2004;4(1):19-38.
2003: Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli; Ahmed Qasem; santi spampinato; Maria Calienni
Conformational analysis and mu-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent.
Organic & biomolecular chemistry 2003;1(17):3010-4.
2003: santi spampinato; Ahmed Qasem; Maria Calienni; Giovanna Murari; Luca Gentilucci; Alessandra Tolomelli; Giuliana Cardillo
Antinociception by a peripherally administered novel endomorphin-1 analogue containing beta-proline.
European journal of pharmacology 2003;469(1-3):89-95.
2003: Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli; Maria Calienni; Ahmed Qasem; santi spampinato
Stability against enzymatic hydrolysis of endomorphin-1 analogues containing beta-proline.
Organic & biomolecular chemistry 2003;1(9):1498-502.
2002: Giuliana Cardillo; Luca Gentilucci; Valeria De Matteis
Lewis acid-promoted synthesis and reactivity of beta-O-benzylhydroxylamino imides derived from D-glyceraldehyde.
The Journal of organic chemistry 2002;67(17):5957-62.
2002: Giuliana Cardillo; Luca Gentilucci; Ahmed Qasem; Fabio Sgarzi; santi spampinato
Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance.
Journal of medicinal chemistry 2002;45(12):2571-8.
2001: Giuliana Cardillo; Luca Gentilucci; Massimo Gianotti; Rossana Perciaccante; Alessandra Tolomelli
Synthesis of aziridine-2,2-dicarboxylates via 1,4-addition of N,O-(bistrimethylsilyl)hydroxylamine to alpha,beta-unsaturated malonates.
The Journal of organic chemistry 2001;66(25):8657-60.
2001: Giuliana Cardillo; Luca Gentilucci; Massimo Gianotti; Alessandra Tolomelli
NMR investigations on boron complexes in the conjugate addition on alpha,beta-unsaturated imides.
Organic letters 2001;3(8):1165-7.
2000: Giuliana Cardillo; Luca Gentilucci; Paolo Melchiorre; santi spampinato
Synthesis and binding activity of endomorphin-1 analogues containing beta-amino acids.
Bioorganic & medicinal chemistry letters 2000;10(24):2755-8.
2000: S Armaroli; Giuliana Cardillo; Luca Gentilucci; Massimo Gianotti; Alessandra Tolomelli
A new selective synthesis of the Ile-allo-Thr-Gly tripeptide fragment of lysobactin.
Organic letters 2000;2(8):1105-7.