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Susan Gentleman

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Preethi Chander; Susan Gentleman; Eugenia Poliakov; T Michael Redmond
Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression.
Eugenia Poliakov; Igor B Rogozin; Olivia Stearn; Maria Mercedes Campos; Susan Gentleman; Alexander N Gubin; Yan Li; T Michael Redmond
Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates.
Eugenia Poliakov; Michael Ayele; Preethi Chander; Susan Gentleman; Stephanie Kuo; Toral Parikh; T Michael Redmond
Aromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity.

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All Publications

2012: Preethi Chander; Susan Gentleman; Eugenia Poliakov; T Michael Redmond
Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression.
The Journal of biological chemistry 2012;287(36):30552-9.
2012: Eugenia Poliakov; Igor B Rogozin; Olivia Stearn; Maria Mercedes Campos; Susan Gentleman; Alexander N Gubin; Yan Li; T Michael Redmond
Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates.
PloS one 2012;7(11):e49975.
2011: Eugenia Poliakov; Michael Ayele; Preethi Chander; Susan Gentleman; Stephanie Kuo; Toral Parikh; T Michael Redmond
Aromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity.
Biochemistry 2011;50(32):6739-41.
2010: T Michael Redmond; Eugenia Poliakov; Stephanie Kuo; Preethi Chander; Susan Gentleman
RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization.
The Journal of biological chemistry 2010;285(3):1919-27.
2009: Eugenia Poliakov; Susan Gentleman; Preethi Chander; Francis X Cunningham; Bella L Grigorenko; Alexander V Nemuhin; T Michael Redmond
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.
BMC biochemistry 2009;10():31.
2007: T Michael Redmond; Charles H Weber; Eugenia Poliakov; Shirley Yu; Susan Gentleman
Effect of Leu/Met variation at residue 450 on isomerase activity and protein expression of RPE65 and its modulation by variation at other residues.
Molecular vision 2007;13():1813-21.
2006: Don-Il Ham; Chiaki Fujimoto; Susan Gentleman; Chi-Chao Chan; Cheng-Rong Yu; Shirley Yu; Charles E Egwuagu; T Michael Redmond; Igal Gery
The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains.
Experimental eye research 2006;83(4):897-902.
2006: Gennadiy Moiseyev; Yusuke Takahashi; Ying Chen; Susan Gentleman; T Michael Redmond; Rosalie K Crouch; Jian-Xing Ma
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle.
The Journal of biological chemistry 2006;281(5):2835-40.
2005: T Michael Redmond; Eugenia Poliakov; Shirley Yu; Jen-Yue Tsai; Zhongjian Lu; Susan Gentleman
Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13658-63.
2005: Eugenia Poliakov; Susan Gentleman; Francis X Cunningham; Nancy J Miller-Ihli; T Michael Redmond
Key role of conserved histidines in recombinant mouse beta-carotene 15,15'-monooxygenase-1 activity.
The Journal of biological chemistry 2005;280(32):29217-23.
2003: Ana Boulanger; Pamela McLemore; Neal G Copeland; Debra J Gilbert; Nancy A Jenkins; Shirley S Yu; Susan Gentleman; T Michael Redmond
Identification of beta-carotene 15, 15'-monooxygenase as a peroxisome proliferator-activated receptor target gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1304-6.
2003: Rizwan A Bhatti; Shirley Yu; Ana Boulanger; Robert Fariss; Yan Guo; Steven L Bernstein; Susan Gentleman; T Michael Redmond
Expression of beta-carotene 15,15' monooxygenase in retina and RPE-choroid.
Investigative ophthalmology & visual science 2003;44(1):44-9.
2002: Don-Il Ham; Susan Gentleman; Chi-Chao Chan; J Hugh McDowell; T Michael Redmond; Igal Gery
RPE65 is highly uveitogenic in rats.
Investigative ophthalmology & visual science 2002;43(7):2258-63.
2001: T Michael Redmond; Susan Gentleman; Todd Duncan; Shirley Yu; Barbara Wiggert; Elisabeth Gantt; Francis X Cunningham
Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase.
The Journal of biological chemistry 2001;276(9):6560-5.
2000: Michael Danciger; Michael T Matthes; D Yasamura; Novrouz B Akhmedov; Tammy M Rickabaugh; Susan Gentleman; T Michael Redmond; M M La Vail; Debora B Farber
A QTL on distal chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(6):422-7.
1999: T Putilina; P Wong; Susan Gentleman
The DHHC domain: a new highly conserved cysteine-rich motif.
Molecular and cellular biochemistry 1999;195(1-2):219-26.
1998: T Putilina; Cynthia Jaworski; Susan Gentleman; B McDonald; M Kadiri; P Wong
Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain.
Biochemical and biophysical research communications 1998;252(2):433-9.