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Dessislava Georgieva

Research Profile

Chemicals & Drugs

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Viperidae

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Genes & Molecular Sequences

Amino Acid Sequences

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Dessislava Georgieva; Dominik Oberthür; Raghuvir K Arni; Friedrich Buck; Monika Coronado; Deyan Duhalov; Christian Betzel
Crystal structure of a dimeric Ser49- PLA₂-like myotoxic component of the Vipera ammodytes meridionalis venomics reveals determinants of myotoxicity and membrane damaging activity.
Aisha Munawar; Hartmut Schlüter; Patrick Spencer; Maria Trusch; Deyan Duhalov; Violette Frochaux; Nicolay Genov; Dessislava Georgieva; Sönke Harder; Raghuvir K Arni; Christian Betzel
Venom peptide analysis of Vipera ammodytes meridionalis (Viperinae) and Bothrops jararacussu (Crotalinae) demonstrates subfamily-specificity of the peptidome in the family Viperidae.
Dessislava Georgieva; Michaela Öhler; Jana Seifert; Patrick Spencer; Martin von Bergen; Raghuvir K Arni; Nicolay Genov; Christian Betzel
Pseudechis australis venomics: adaptation for a defense against microbial pathogens and recruitment of body transferrin.

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All Publications

2012: Dessislava Georgieva; Dominik Oberthür; Raghuvir K Arni; Friedrich Buck; Monika Coronado; Deyan Duhalov; Christian Betzel
Crystal structure of a dimeric Ser49- PLA₂-like myotoxic component of the Vipera ammodytes meridionalis venomics reveals determinants of myotoxicity and membrane damaging activity.
Molecular bioSystems 2012;8(5):1405-11.
2011: Aisha Munawar; Hartmut Schlüter; Patrick Spencer; Maria Trusch; Deyan Duhalov; Violette Frochaux; Nicolay Genov; Dessislava Georgieva; Sönke Harder; Raghuvir K Arni; Christian Betzel
Venom peptide analysis of Vipera ammodytes meridionalis (Viperinae) and Bothrops jararacussu (Crotalinae) demonstrates subfamily-specificity of the peptidome in the family Viperidae.
Molecular bioSystems 2011;7(12):3298-307.
2011: Dessislava Georgieva; Michaela Öhler; Jana Seifert; Patrick Spencer; Martin von Bergen; Raghuvir K Arni; Nicolay Genov; Christian Betzel
Pseudechis australis venomics: adaptation for a defense against microbial pathogens and recruitment of body transferrin.
Journal of proteome research 2011;10(5):2440-64.
2011: Dessislava Georgieva; Kerstin Greunke; Raghuvir K Arni; Christian Betzel
Three-dimensional modelling of honeybee venom allergenic proteases: relation to allergenicity.
Zeitschrift für Naturforschung. C, Journal of biosciences 2011;66(5-6):305-12.
2011: Dessislava Georgieva; Mario Murakami; Markus Perband; Raghuvir K Arni; Christian Betzel
The structure of a native l-amino acid oxidase, the major component of the Vipera ammodytes ammodytes venomic, reveals dynamic active site and quaternary structure stabilization by divalent ions.
Molecular bioSystems 2011;7(2):379-84.
2010: Dessislava Georgieva; Kerstin Greunke; Christian Betzel
Three-dimensional model of the honeybee venom allergen Api m 7: structural and functional insights.
Molecular bioSystems 2010;6(6):1056-60.
2010: Dessislava Georgieva; Michaela Ohler; Jana Seifert; Martin von Bergen; Raghuvir K Arni; Nicolay Genov; Christian Betzel
Snake venomic of Crotalus durissus terrificus--correlation with pharmacological activities.
Journal of proteome research 2010;9(5):2302-16.
2010: Dessislava Georgieva; Lars Redecke; Martin von Bergen; Nicolay Genov; Chrsitian Betzel
Interactions of ginkgolides A and B with a recombinant human prion protein.
Protein and peptide letters 2010;17(3):399-404.
2009: Dessislava Georgieva; Kerstin Greunke; Nicolay Genov; Christian Betzel
3-D Model of the bee venom acid phosphatase: insights into allergenicity.
Biochemical and biophysical research communications 2009;378(4):711-5.
2008: Dessislava Georgieva; Anna Kardas; Friedrich Buck; Markus Perbandt; Christian Betzel
Isolation, crystallization and preliminary X-ray diffraction analysis of L-amino-acid oxidase from Vipera ammodytes ammodytes venom.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 10):918-21.
2008: Dessislava Georgieva; Michaela Risch; Anna Kardas; Friedrich Buck; Martin von Bergen; Christian Betzel
Comparative analysis of the venom proteomes of Vipera ammodytes ammodytes and Vipera ammodytes meridionalis.
Journal of proteome research 2008;7(3):866-86.
2007: Lars Redecke; Martin von Bergen; Joachim Clos; Peter V Konarev; Dmitri I Svergun; Ursula E A Fittschen; José A C Broekaert; Oliver Bruns; Dessislava Georgieva; Eckhard Mandelkow; Nicolay Genov; Christian Betzel
Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro.
Journal of structural biology 2007;157(2):308-20.
2006: Dessislava Georgieva; Daniel Schwark; Martin von Bergen; Lars Redecke; Nicolay Genov; Christian Betzel
Interactions of recombinant prions with compounds of therapeutical significance.
Biochemical and biophysical research communications 2006;344(2):463-70.
2006: Dessislava Georgieva; Nicolay Genov; Wolfgang Voelter; Christian Betzel
Catalytic efficiencies of alkaline proteinases from microorganisms.
Zeitschrift für Naturforschung. C, Journal of biosciences 2006;61(5-6):445-52.
2005: Dessislava Georgieva; Nicolay Genov; Christian Betzel
Bacillus licheniformis variant DY proteinase: specificity in relation to the geometry of the substrate recognition site.
Current microbiology 2005;51(2):71-4.
2005: Lars Redecke; Wolfram Meyer-Klaucke; Mirjam Koker; Joachim Clos; Dessislava Georgieva; Nicolay Genov; Hartmut Echner; Hubert Kalbacher; Markus Perbandt; Reinhard Bredehorst; Wolfgang Voelter; Christian Betzel
Comparative analysis of the human and chicken prion protein copper binding regions at pH 6.5.
The Journal of biological chemistry 2005;280(14):13987-92.
2005: Dessislava Georgieva; Daniel Schwark; Peter Nikolov; Krassimira Idakieva; Katja Parvanova; Karsten Dierks; Nicolay Genov; Christian Betzel
Conformational states of the Rapana thomasiana hemocyanin and its substructures studied by dynamic light scattering and time-resolved fluorescence spectroscopy.
Biophysical journal 2005;88(2):1276-82.
2004: Dessislava Georgieva; Wojciech Rypniewski; Hartmut Echner; Markus Perbandt; Mirjam Koker; Joachim Clos; Lars Redecke; Reinhard Bredehorst; Wolfgang Voelter; Nicolay Genov; Christian Betzel
Synthetic human prion protein octapeptide repeat binds to the proteinase K active site.
Biochemical and biophysical research communications 2004;325(4):1406-11.
2004: Dessislava Georgieva; Mirjam Koker; Lars Redecke; Markus Perbandt; Joachim Clos; Reinhard Bredehorst; Nicolay Genov; Christian Betzel
Oligomerization of the proteolytic products is an intrinsic property of prion proteins.
Biochemical and biophysical research communications 2004;323(4):1278-86.
2004: Dessislava Georgieva; Wojciech Rypniewski; Azat G Gabdoulkhakov; Nicolay Genov; Christian Betzel
Asp49 phospholipase A(2)-elaidoylamide complex: a new mode of inhibition.
Biochemical and biophysical research communications 2004;319(4):1314-21.
2004: Dessislava Georgieva; Markus Perbandt; Wojciech Rypniewski; Krassimir Hristov; Nicolay Genov; Christian Betzel
The X-ray structure of a snake venom Gln48 phospholipase A2 at 1.9A resolution reveals anion-binding sites.
Biochemical and biophysical research communications 2004;316(1):33-8.
2004: Dessislava Georgieva; Nicolay Genov; Markus Perbandt; Wolfgang Voelter; Christian Betzel
Contribution of disulfide bonds and calcium to Molluscan hemocyanin stability.
Zeitschrift für Naturforschung. C, Journal of biosciences 2004;59(3-4):281-7.
2004: Dessislava Georgieva; Nicolay Genov; Krassimir Hristov; Karsten Dierks; Christian Betzel
Interactions of the neurotoxin vipoxin in solution studied by dynamic light scattering.
Biophysical journal 2004;86(1 Pt 1):461-6.
2003: Markus Perbandt; Inn-Ho Tsai; Annemarie Fuchs; Sankaran Banumathi; Kanagalaghatta R Rajashankar; Dessislava Georgieva; Narayana Kalkura; Tej P Singh; Nicolay Genov; Christian Betzel
Structure of the heterodimeric neurotoxic complex viperotoxin F (RV-4/RV-7) from the venom of Vipera russelli formosensis at 1.9 A resolution.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 10):1679-87.
2003: Dessislava Georgieva; Wojciech Rypniewski; Markus Perbandt; Mahendra Jain; Nicolay Genov; Christian Betzel
Crystallization and preliminary X-ray diffraction studies of a toxic phospholipase A2 from the venom of Vipera ammodytes meridionalis complexed to a synthetic inhibitor.
Biochimica et biophysica acta 2003;1650(1-2):1-3.
2003: Dessislava Georgieva; Nicolay Genov; Peter Nikolov; Boris Aleksiev; Kanagalaghatta R Rajashankar; Wolfgang Voelter; Christian Betzel
Structure-function relationships in the neurotoxin Vipoxin from the venom of Vipera ammodytes meridionalis.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2003;59(3):617-27.
2002: Sabine Windhorst; Eva Frank; Dessislava Georgieva; Nicolay Genov; Friedrich Buck; Peter Borowski; Wolfgang Weber
The major extracellular protease of the nosocomial pathogen Stenotrophomonas maltophilia: characterization of the protein and molecular cloning of the gene.
The Journal of biological chemistry 2002;277(13):11042-9.
2001: Dessislava Georgieva; Stanka Stoeva; Wolfgang Voelter; Nicolay Genov
Viviparus ater hemocyanin: investigation of the dioxygen-binding site and stability of the oxy- and apo-forms.
Zeitschrift für Naturforschung. C, Journal of biosciences 2001;56(9-10):843-7.
2001: Stanka Stoeva; Krassimira Idakieva; Dessislava Georgieva; Wolfgang Voelter; Nicolay Genov
Penaeus monodon (tiger shrimp) hemocyanin: subunit composition and thermostability.
Zeitschrift für Naturforschung. C, Journal of biosciences 2001;56(5-6):416-22.
2001: Dessislava Georgieva; Stanka Stoeva; Wolfgang Voelter; Nicolay Genov; Christian Betzel
Substrate specificity of the highly alkalophilic bacterial proteinase esperase: relation to the x-ray structure.
Current microbiology 2001;42(5):368-71.
2001: Dessislava Georgieva; Stanka Stoeva; Wolfgang Voelter; Nicolay Genov; Christian Betzel
Differences in the specificities of the highly alkalophilic proteinases Savinase and Esperase imposed by changes in the rigidity and geometry of the substrate binding sites.
Archives of biochemistry and biophysics 2001;387(2):197-201.
2000: Dessislava Georgieva; Christian Betzel; Boris Aleksiev; Nicolay Genov
Spectroscopic investigation of calcium binding sites in the neurotoxin vipoxin and its components-relation with the X-ray structure.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2000;56(14):2811-6.
2000: Dessislava Georgieva; Stanka Stoeva; V Ivanova; A Gusterova; Wolfgang Voelter
Specificity of a neutral Zn-dependent proteinase from Thermoactinomyces sacchari toward the oxidized insulin B chain.
Current microbiology 2000;41(1):70-2.
1999: Dessislava Georgieva; Nicolay Genov; Kanagalaghatta R Rajashankar; Boris Aleksiev; Christian Betzel
Spectroscopic investigation of phenolic groups ionization in the vipoxin neurotoxic phospholipase A2: comparison with the X-ray structure in the region of the tyrosyl residues.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 1999;55A(1):239-44.
1998: Dessislava Georgieva; Peter Nikolov; Christian Betzel
Steady-state and time-resolved fluorescence of Esperase: comparison with the X-ray structure in the region of the two tryptophans.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 1998;54A(8):1109-16.
1998: P Dolashka; Dessislava Georgieva; Stanka Stoeva; Nicolay Genov; R Rachev; A Gusterova; Wolfgang Voelter
A novel thermostable neutral proteinase from Saccharomonospora canescens.
Biochimica et biophysica acta 1998;1382(2):207-16.
1997: Nicolay Genov; I Goshev; D Nikolova; Dessislava Georgieva; B Filippi; I Svendsen
A novel thermostable inhibitor of trypsin and subtilisin from the seeds of Brassica nigra: amino acid sequence, inhibitory and spectroscopic properties and thermostability.
Biochimica et biophysica acta 1997;1341(2):157-64.