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Costa Georgopoulos

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Nicolas Bruel; Marie-Pierre Castanié-Cornet; Anne-Marie Cirinesi; Costa Georgopoulos; Gregory Koningstein; Joen Luirink; Pierre Genevaux
Hsp33 controls elongation factor-Tu stability and allows Escherichia coli growth in the absence of the major DnaK and trigger factor chaperones.
Debbie Ang; Costa Georgopoulos
An ORFan no more: the bacteriophage T4 39.2 gene product, NwgI, modulates GroEL chaperone function.
Elsa Perrody; Françoise Schwager; Samuel Tranier; Anne-Marie Cirinesi; Carine Desplats; Costa Georgopoulos; France Keppel; Pierre Genevaux
A bacteriophage-encoded J-domain protein interacts with the DnaK/Hsp70 chaperone and stabilizes the heat-shock factor σ32 of Escherichia coli.

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All Publications

2012: Nicolas Bruel; Marie-Pierre Castanié-Cornet; Anne-Marie Cirinesi; Costa Georgopoulos; Gregory Koningstein; Joen Luirink; Pierre Genevaux
Hsp33 controls elongation factor-Tu stability and allows Escherichia coli growth in the absence of the major DnaK and trigger factor chaperones.
The Journal of biological chemistry 2012;287(53):44435-46.
2012: Debbie Ang; Costa Georgopoulos
An ORFan no more: the bacteriophage T4 39.2 gene product, NwgI, modulates GroEL chaperone function.
Genetics 2012;190(3):989-1000.
2012: Elsa Perrody; Françoise Schwager; Samuel Tranier; Anne-Marie Cirinesi; Carine Desplats; Costa Georgopoulos; France Keppel; Pierre Genevaux
A bacteriophage-encoded J-domain protein interacts with the DnaK/Hsp70 chaperone and stabilizes the heat-shock factor σ32 of Escherichia coli.
PLoS genetics 2012;8(11):e1003037.
2010: Samer Sakr; Anne-Marie Cirinesi; Ronald S Ullers; Françoise Schwager; Costa Georgopoulos; Pierre Genevaux
Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.
The Journal of biological chemistry 2010;285(30):23506-14.
2010: B Erin Horne; Tingfeng Li; Pierre Genevaux; Costa Georgopoulos; Samuel J Landry
The Hsp40 J-domain stimulates Hsp70 when tethered by the client to the ATPase domain.
The Journal of biological chemistry 2010;285(28):21679-88.
2008: Peter Bross; Søren Naundrup; Jakob Hansen; Marit Nyholm Nielsen; Jane Hvarregaard Christensen; Mogens Kruhøffer; Johan Palmfeldt; Thomas J Corydon; Niels Gregersen; Debbie Ang; Costa Georgopoulos; Kåre Lehmann Nielsen
The Hsp60-(p.V98I) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.
The Journal of biological chemistry 2008;283(23):15694-700.
2007: Pierre Genevaux; Costa Georgopoulos; William L Kelley
The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions.
Molecular microbiology 2007;66(4):840-57.
2007: Jakob Hansen; Kirsten Svenstrup; Debbie Ang; Marit Nyholm Nielsen; Jane H Christensen; Niels Gregersen; Jørgen E Nielsen; Costa Georgopoulos; Peter Bross
A novel mutation in the HSPD1 gene in a patient with hereditary spastic paraplegia.
Journal of neurology 2007;254(7):897-900.
2007: Sathish K Lakshmipathy; Sladjana Tomic; Christian M Kaiser; Hung-Chun Chang; Pierre Genevaux; Costa Georgopoulos; José M Barral; Arthur E Johnson; F Ulrich Hartl; Stephanie A Etchells
Identification of nascent chain interaction sites on trigger factor.
The Journal of biological chemistry 2007;282(16):12186-93.
2007: Patrick H Tu Quoc; Pierre Genevaux; Maria Pajunen; Harri Savilahti; Costa Georgopoulos; Jacques Schrenzel; William L Kelley
Isolation and characterization of biofilm formation-defective mutants of Staphylococcus aureus.
Infection and immunity 2007;75(3):1079-88.
2007: Ronald S Ullers; Debbie Ang; francoise schwager; Costa Georgopoulos; Pierre Genevaux
Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3101-6.
2007: Peter Bross; Zhijie Li; Jakob Hansen; Jens Jacob Hansen; Marit Nyholm Nielsen; Thomas J Corydon; Costa Georgopoulos; Debbie Ang; Jytte Banner Lundemose; Klary Niezen-Koning; Hans Eiberg; Huanming Yang; Steen Kølvraa; Lars Bolund; Niels Gregersen
Single-nucleotide variations in the genes encoding the mitochondrial Hsp60/Hsp10 chaperone system and their disease-causing potential.
Journal of human genetics 2007;52(1):56-65.
2006: Costa Georgopoulos
Toothpicks, serendipity and the emergence of the Escherichia coli DnaK (Hsp70) and GroEL (Hsp60) chaperone machines.
Genetics 2006;174(4):1699-707.
2006: Gordana Cogelja Cajo; B Erin Horne; William L Kelley; francoise schwager; Costa Georgopoulos; Pierre Genevaux
The role of the DIF motif of the DnaJ (Hsp40) co-chaperone in the regulation of the DnaK (Hsp70) chaperone cycle.
The Journal of biological chemistry 2006;281(18):12436-44.
2005: Michael J Kerner; Dean J Naylor; Yasushi Ishihama; Tobias Maier; Hung-Chun Chang; Anna stines; Costa Georgopoulos; Dmitrij Frishman; Manajit Hayer-Hartl; Matthias Mann; F Ulrich Hartl
Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli.
Cell 2005;122(2):209-20.
2004: Eyal Gur; Dvora Biran; Nelia Shechter; Pierre Genevaux; Costa Georgopoulos; Eliora Z Ron
The Escherichia coli DjlA and CbpA proteins can substitute for DnaJ in DnaK-mediated protein disaggregation.
Journal of bacteriology 2004;186(21):7236-42.
2004: Frank Shewmaker; Michael J Kerner; Manajit Hayer-Hartl; Gracjana Klein; Costa Georgopoulos; Samuel J Landry
A mobile loop order-disorder transition modulates the speed of chaperonin cycling.
Protein science : a publication of the Protein Society 2004;13(8):2139-48.
2004: Ronald S Ullers; Joen Luirink; Nellie Harms; francoise schwager; Costa Georgopoulos; Pierre Genevaux
SecB is a bona fide generalized chaperone in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7583-8.
2004: Vishwas R Agashe; Suranjana Guha; Hung-Chun Chang; Pierre Genevaux; Manajit Hayer-Hartl; Markus J Stemp; Costa Georgopoulos; F Ulrich Hartl; José M Barral
Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed.
Cell 2004;117(2):199-209.
2004: Pierre Genevaux; France Keppel; francoise schwager; Petra S Langendijk-Genevaux; F Ulrich Hartl; Costa Georgopoulos
In vivo analysis of the overlapping functions of DnaK and trigger factor.
EMBO reports 2004;5(2):195-200.
2004: Luis Figueiredo; Daniel Klunker; Debbie Ang; Dean J Naylor; Michael J Kerner; Costa Georgopoulos; F Ulrich Hartl; Manajit Hayer-Hartl
Functional characterization of an archaeal GroEL/GroES chaperonin system: significance of substrate encapsulation.
The Journal of biological chemistry 2004;279(2):1090-9.
2003: Pierre Genevaux; Florence Lang; francoise schwager; Jai V Vartikar; Mary Kathleen Rundell; James M Pipas; Costa Georgopoulos; William L Kelley
Simian virus 40 T antigens and J domains: analysis of Hsp40 cochaperone functions in Escherichia coli.
Journal of virology 2003;77(19):10706-13.
2003: Abhijit A Sardesai; Pierre Genevaux; francoise schwager; Debbie Ang; Costa Georgopoulos
The OmpL porin does not modulate redox potential in the periplasmic space of Escherichia coli.
The EMBO journal 2003;22(7):1461-6.
2002: Pierre Genevaux; francoise schwager; Costa Georgopoulos; William L Kelley
Scanning mutagenesis identifies amino acid residues essential for the in vivo activity of the Escherichia coli DnaJ (Hsp40) J-domain.
Genetics 2002;162(3):1045-53.
2002: France Keppel; Monique Rychner; Costa Georgopoulos
Bacteriophage-encoded cochaperonins can substitute for Escherichia coli's essential GroES protein.
EMBO reports 2002;3(9):893-8.
2002: Jens Jacob Hansen; Alexandra Dürr; Isabelle Cournu-Rebeix; Costa Georgopoulos; Debbie Ang; Marit Nyholm Nielsen; Claire-Sophie Davoine; Alexis Brice; Bertrand Fontaine; Niels Gregersen; Peter Bross
Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.
American journal of human genetics 2002;70(5):1328-32.
2001: Pierre Genevaux; francoise schwager; Costa Georgopoulos; William L Kelley
The djlA gene acts synergistically with dnaJ in promoting Escherichia coli growth.
Journal of bacteriology 2001;183(19):5747-50.
2001: G Klein; Costa Georgopoulos
Identification of important amino acid residues that modulate binding of Escherichia coli GroEL to its various cochaperones.
Genetics 2001;158(2):507-17.
2001: Bogdan Banecki; A Wawrzynow; J Puzewicz; Costa Georgopoulos; Maciej Zylicz
Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.
The Journal of biological chemistry 2001;276(22):18843-8.
2001: Debbie Ang; A Richardson; M P Mayer; France Keppel; H Krisch; Costa Georgopoulos
Pseudo-T-even bacteriophage RB49 encodes CocO, a cochaperonin for GroEL, which can substitute for Escherichia coli's GroES and bacteriophage T4's Gp31.
The Journal of biological chemistry 2001;276(12):8720-6.
2001: Pierre Genevaux; A Wawrzynow; Maciej Zylicz; Costa Georgopoulos; William L Kelley
DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction.
The Journal of biological chemistry 2001;276(11):7906-12.
2001: A Richardson; francoise schwager; Samuel J Landry; Costa Georgopoulos
The importance of a mobile loop in regulating chaperonin/ co-chaperonin interaction: humans versus Escherichia coli.
The Journal of biological chemistry 2001;276(7):4981-7.
2000: Debbie Ang; France Keppel; G Klein; A Richardson; Costa Georgopoulos
Genetic analysis of bacteriophage-encoded cochaperonins.
Annual review of genetics 2000;34():439-456.
1999: A Richardson; Costa Georgopoulos
Genetic analysis of the bacteriophage T4-encoded cochaperonin Gp31.
Genetics 1999;152(4):1449-57.
1999: S A Teter; Walid A Houry; Debbie Ang; T Tradler; D Rockabrand; G Fischer; P Blum; Costa Georgopoulos; F Ulrich Hartl
Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chains.
Cell 1999;97(6):755-65.
1999: M Gonciarz-Swiatek; A Wawrzynow; S J Um; BRIAN LEARN; ROGER MCMACKEN; William L Kelley; Costa Georgopoulos; O Sliekers; Maciej Zylicz
Recognition, targeting, and hydrolysis of the lambda O replication protein by the ClpP/ClpX protease.
The Journal of biological chemistry 1999;274(20):13999-4005.
1999: A Blaszczak; Costa Georgopoulos; Krzysztof Liberek
On the mechanism of FtsH-dependent degradation of the sigma 32 transcriptional regulator of Escherichia coli and the role of the Dnak chaperone machine.
Molecular microbiology 1999;31(1):157-66.
1999: A Richardson; S M van der Vies; France Keppel; A Taher; Samuel J Landry; Costa Georgopoulos
Compensatory changes in GroEL/Gp31 affinity as a mechanism for allele-specific genetic interaction.
The Journal of biological chemistry 1999;274(1):52-8.
1998: Maciej Zylicz; Krzysztof Liberek; A Wawrzynow; Costa Georgopoulos
Formation of the preprimosome protects lambda O from RNA transcription-dependent proteolysis by ClpP/ClpX.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15259-63.
1998: F Weber; France Keppel; Costa Georgopoulos; Manajit Hayer-Hartl; F Ulrich Hartl
The oligomeric structure of GroEL/GroES is required for biologically significant chaperonin function in protein folding.
Nature structural biology 1998;5(11):977-85.
1998: L Goffin; Costa Georgopoulos
Genetic and biochemical characterization of mutations affecting the carboxy-terminal domain of the Escherichia coli molecular chaperone DnaJ.
Molecular microbiology 1998;30(2):329-40.
1998: A Richardson; Samuel J Landry; Costa Georgopoulos
The ins and outs of a molecular chaperone machine.
Trends in biochemical sciences 1998;23(4):138-43.
1997: Olivier Deloche; Krzysztof Liberek; Maciej Zylicz; Costa Georgopoulos
Purification and biochemical properties of Saccharomyces cerevisiae Mdj1p, the mitochondrial DnaJ homologue.
The Journal of biological chemistry 1997;272(45):28539-44.
1997: Olivier Deloche; William L Kelley; Costa Georgopoulos
Structure-function analyses of the Ssc1p, Mdj1p, and Mge1p Saccharomyces cerevisiae mitochondrial proteins in Escherichia coli.
Journal of bacteriology 1997;179(19):6066-75.
1997: William L Kelley; Costa Georgopoulos
Positive control of the two-component RcsC/B signal transduction network by DjlA: a member of the DnaJ family of molecular chaperones in Escherichia coli.
Molecular microbiology 1997;25(5):913-31.
1997: William L Kelley; Costa Georgopoulos
The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3679-84.
1997: Dominique M Missiakas; M P Mayer; Marc Lemaire; Costa Georgopoulos; Satish Raina
Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins.
Molecular microbiology 1997;24(2):355-71.
1996: Samuel J Landry; A Taher; Costa Georgopoulos; S M van der Vies
Interplay of structure and disorder in cochaperonin mobile loops.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11622-7.
1996: Olivier Deloche; Costa Georgopoulos
Purification and biochemical properties of Saccharomyces cerevisiae's Mge1p, the mitochondrial cochaperone of Ssc1p.
The Journal of biological chemistry 1996;271(39):23960-6.
1996: B Wu; A Wawrzynow; Maciej Zylicz; Costa Georgopoulos
Structure-function analysis of the Escherichia coli GrpE heat shock protein.
The EMBO journal 1996;15(18):4806-16.
1996: B Banecki; Krzysztof Liberek; D Wall; A Wawrzynów; Costa Georgopoulos; Enrico Bertoli; Fabio Tanfani; Maciej Zylicz
Structure-function analysis of the zinc finger region of the DnaJ molecular chaperone.
The Journal of biological chemistry 1996;271(25):14840-8.
1996: JH Zeilstra-Ryalls; Olivier Fayet; Costa Georgopoulos
In vivo protein folding: suppressor analysis of mutations in the groES cochaperone gene of Escherichia coli.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(1):148-52.
1995: A Blaszczak; Maciej Zylicz; Costa Georgopoulos; Krzysztof Liberek
Both ambient temperature and the DnaK chaperone machine modulate the heat shock response in Escherichia coli by regulating the switch between sigma 70 and sigma 32 factors assembled with RNA polymerase.
The EMBO journal 1995;14(20):5085-93.
1995: A Wawrzynów; B Banecki; D Wall; Krzysztof Liberek; Costa Georgopoulos; Maciej Zylicz
ATP hydrolysis is required for the DnaJ-dependent activation of DnaK chaperone for binding to both native and denatured protein substrates.
The Journal of biological chemistry 1995;270(33):19307-11.
1995: A Polissi; L Goffin; Costa Georgopoulos
The Escherichia coli heat shock response and bacteriophage lambda development.
FEMS microbiology reviews 1995;17(1-2):159-69.
1995: Krzysztof Liberek; D Wall; Costa Georgopoulos
The DnaJ chaperone catalytically activates the DnaK chaperone to preferentially bind the sigma 32 heat shock transcriptional regulator.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6224-8.
1995: A Wawrzynow; D Wojtkowiak; Jaroslaw Marszalek; B Banecki; M Jonsen; B Graves; Costa Georgopoulos; Maciej Zylicz
The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.
The EMBO journal 1995;14(9):1867-77.
1995: Satish Raina; Dominique M Missiakas; Costa Georgopoulos
The rpoE gene encoding the sigma E (sigma 24) heat shock sigma factor of Escherichia coli.
The EMBO journal 1995;14(5):1043-55.
1995: D Wall; Maciej Zylicz; Costa Georgopoulos
The conserved G/F motif of the DnaJ chaperone is necessary for the activation of the substrate binding properties of the DnaK chaperone.
The Journal of biological chemistry 1995;270(5):2139-44.
1994: B Wu; D Ang; M Snavely; Costa Georgopoulos
Isolation and characterization of point mutations in the Escherichia coli grpE heat shock gene.
Journal of bacteriology 1994;176(22):6965-73.
1994: JH Zeilstra-Ryalls; Olivier Fayet; Costa Georgopoulos
Two classes of extragenic suppressor mutations identify functionally distinct regions of the GroEL chaperone of Escherichia coli.
Journal of bacteriology 1994;176(21):6558-65.
1994: C Barrios; Costa Georgopoulos; Paul-Henri Lambert; G Del Giudice
Heat shock proteins as carrier molecules: in vivo helper effect mediated by Escherichia coli GroEL and DnaK proteins requires cross-linking with antigen.
Clinical and experimental immunology 1994;98(2):229-33.
1994: Dominique M Missiakas; Costa Georgopoulos; Satish Raina
The Escherichia coli dsbC (xprA) gene encodes a periplasmic protein involved in disulfide bond formation.
The EMBO journal 1994;13(8):2013-20.
1994: S M van der Vies; A A Gatenby; Costa Georgopoulos
Bacteriophage T4 encodes a co-chaperonin that can substitute for Escherichia coli GroES in protein folding.
Nature 1994;368(6472):654-6.
1994: D Wall; Maciej Zylicz; Costa Georgopoulos
The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication.
The Journal of biological chemistry 1994;269(7):5446-51.
1993: A Ziemienowicz; Dorota Skowyra; JH Zeilstra-Ryalls; Olivier Fayet; Costa Georgopoulos; Maciej Zylicz
Both the Escherichia coli chaperone systems, GroEL/GroES and DnaK/DnaJ/GrpE, can reactivate heat-treated RNA polymerase. Different mechanisms for the same activity.
The Journal of biological chemistry 1993;268(34):25425-31.
1993: C Wyman; C Vasilikiotis; D Ang; Costa Georgopoulos; H Echols
Function of the GrpE heat shock protein in bidirectional unwinding and replication from the origin of phage lambda.
The Journal of biological chemistry 1993;268(33):25192-6.
1993: D Wojtkowiak; Costa Georgopoulos; Maciej Zylicz
Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli.
The Journal of biological chemistry 1993;268(30):22609-17.
1993: Satish Raina; Dominique M Missiakas; L Baird; S Kumar; Costa Georgopoulos
Identification and transcriptional analysis of the Escherichia coli htrE operon which is homologous to pap and related pilin operons.
Journal of bacteriology 1993;175(16):5009-21.
1993: Dominique M Missiakas; Costa Georgopoulos; Satish Raina
Identification and characterization of the Escherichia coli gene dsbB, whose product is involved in the formation of disulfide bonds in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7084-8.
1993: S J Landry; JH Zeilstra-Ryalls; Olivier Fayet; Costa Georgopoulos; Lila M Gierasch
Characterization of a functionally important mobile domain of GroES.
Nature 1993;364(6434):255-8.
1993: Dominique M Missiakas; Costa Georgopoulos; Satish Raina
The Escherichia coli heat shock gene htpY: mutational analysis, cloning, sequencing, and transcriptional regulation.
Journal of bacteriology 1993;175(9):2613-24.
1993: J Osipiuk; Costa Georgopoulos; Maciej Zylicz
Initiation of lambda DNA replication. The Escherichia coli small heat shock proteins, DnaJ and GrpE, increase DnaK's affinity for the lambda P protein.
The Journal of biological chemistry 1993;268(7):4821-7.
1993: JH Zeilstra-Ryalls; Olivier Fayet; L Baird; Costa Georgopoulos
Sequence analysis and phenotypic characterization of groEL mutations that block lambda and T4 bacteriophage growth.
Journal of bacteriology 1993;175(4):1134-43.
1993: J M Delaney; D Wall; Costa Georgopoulos
Molecular characterization of the Escherichia coli htrD gene: cloning, sequence, regulation, and involvement with cytochrome d oxidase.
Journal of bacteriology 1993;175(1):166-75.
1993: M Karow; Costa Georgopoulos
The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators.
Molecular microbiology 1993;7(1):69-79.
1992: William L Kelley; Costa Georgopoulos
Chaperones and protein folding.
Current opinion in cell biology 1992;4(6):984-91.
1992: M Karow; Olivier Fayet; Costa Georgopoulos
The lethal phenotype caused by null mutations in the Escherichia coli htrB gene is suppressed by mutations in the accBC operon, encoding two subunits of acetyl coenzyme A carboxylase.
Journal of bacteriology 1992;174(22):7407-18.
1992: D Wall; J M Delaney; Olivier Fayet; B Lipinska; T Yamamoto; Costa Georgopoulos
arc-dependent thermal regulation and extragenic suppression of the Escherichia coli cytochrome d operon.
Journal of bacteriology 1992;174(20):6554-62.
1992: B Wu; Costa Georgopoulos; D Ang
The essential Escherichia coli msgB gene, a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE, is identical to dapE.
Journal of bacteriology 1992;174(16):5258-64.
1992: Costa Georgopoulos
The emergence of the chaperone machines.
Trends in biochemical sciences 1992;17(8):295-9.
1992: J M Delaney; Costa Georgopoulos
Physical map locations of the trxB, htrD, cydC, and cydD genes of Escherichia coli.
Journal of bacteriology 1992;174(11):3824-5.
1992: Krzysztof Liberek; T P Galitski; Maciej Zylicz; Costa Georgopoulos
The DnaK chaperone modulates the heat shock response of Escherichia coli by binding to the sigma 32 transcription factor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3516-20.
1992: M Karow; Costa Georgopoulos
Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB.
Journal of bacteriology 1992;174(3):702-10.
1992: J M Delaney; D Ang; Costa Georgopoulos
Isolation and characterization of the Escherichia coli htrD gene, whose product is required for growth at high temperatures.
Journal of bacteriology 1992;174(4):1240-7.
1992: T Ziegelhoffer; P Yau; G N Chandrasekhar; J Kochan; Costa Georgopoulos; Helios Murialdo
The purification and properties of the scaffolding protein of bacteriophage lambda.
The Journal of biological chemistry 1992;267(1):455-61.
1991: D Ang; Krzysztof Liberek; Dorota Skowyra; Maciej Zylicz; Costa Georgopoulos
Biological role and regulation of the universally conserved heat shock proteins.
The Journal of biological chemistry 1991;266(36):24233-6.
1991: Satish Raina; L Mabey; Costa Georgopoulos
The Escherichia coli htrP gene product is essential for bacterial growth at high temperatures: mapping, cloning, sequencing, and transcriptional regulation of htrP.
Journal of bacteriology 1991;173(19):5999-6008.
1991: L Baird; B Lipinska; Satish Raina; Costa Georgopoulos
Identification of the Escherichia coli sohB gene, a multicopy suppressor of the HtrA (DegP) null phenotype.
Journal of bacteriology 1991;173(18):5763-70.
1991: M Karow; Costa Georgopoulos
Sequencing, mutational analysis, and transcriptional regulation of the Escherichia coli htrB gene.
Molecular microbiology 1991;5(9):2285-92.
1991: Krzysztof Liberek; Dorota Skowyra; Maciej Zylicz; C Johnson; Costa Georgopoulos
The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein.
The Journal of biological chemistry 1991;266(22):14491-6.
1991: Satish Raina; Costa Georgopoulos
The htrM gene, whose product is essential for Escherichia coli viability only at elevated temperatures, is identical to the rfaD gene.
Nucleic acids research 1991;19(14):3811-9.
1991: Krzysztof Liberek; Jaroslaw Marszalek; D Ang; Costa Georgopoulos; Maciej Zylicz
Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2874-8.
1991: S F Chang; D Ng; L Baird; Costa Georgopoulos
Analysis of an Escherichia coli dnaB temperature-sensitive insertion mutation and its cold-sensitive extragenic suppressor.
The Journal of biological chemistry 1991;266(6):3654-60.
1991: M Karow; S Raina; Costa Georgopoulos; Olivier Fayet
Complex phenotypes of null mutations in the htr genes, whose products are essential for Escherichia coli growth at elevated temperatures.
Research in microbiology 1991;142(2-3):289-94.
1991: M Karow; Olivier Fayet; A Cegielska; T Ziegelhoffer; Costa Georgopoulos
Isolation and characterization of the Escherichia coli htrB gene, whose product is essential for bacterial viability above 33 degrees C in rich media.
Journal of bacteriology 1991;173(2):741-50.
1991: JH Zeilstra-Ryalls; Olivier Fayet; Costa Georgopoulos
The universally conserved GroE (Hsp60) chaperonins.
Annual review of microbiology 1991;45():301-25.
1990: J Spence; A Cegielska; Costa Georgopoulos
Role of Escherichia coli heat shock proteins DnaK and HtpG (C62.5) in response to nutritional deprivation.
Journal of bacteriology 1990;172(12):7157-66.
1990: Dorota Skowyra; Costa Georgopoulos; Maciej Zylicz
The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner.
Cell 1990;62(5):939-44.
1990: S M Sell; C Eisen; D Ang; Maciej Zylicz; Costa Georgopoulos
Isolation and characterization of dnaJ null mutants of Escherichia coli.
Journal of bacteriology 1990;172(9):4827-35.
1990: Satish Raina; Costa Georgopoulos
A new Escherichia coli heat shock gene, htrC, whose product is essential for viability only at high temperatures.
Journal of bacteriology 1990;172(6):3417-26.
1990: B Lipinska; Maciej Zylicz; Costa Georgopoulos
The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase.
Journal of bacteriology 1990;172(4):1791-7.
1990: L Baird; Costa Georgopoulos
Identification, cloning, and characterization of the Escherichia coli sohA gene, a suppressor of the htrA (degP) null phenotype.
Journal of bacteriology 1990;172(3):1587-94.
1990: Krzysztof Liberek; J Osipiuk; Maciej Zylicz; D Ang; J Skorko; Costa Georgopoulos
Physical interactions between bacteriophage and Escherichia coli proteins required for initiation of lambda DNA replication.
The Journal of biological chemistry 1990;265(6):3022-9.
1990: Costa Georgopoulos; D Ang
The Escherichia coli groE chaperonins.
Seminars in cell biology 1990;1(1):19-25.
1990: F Keppel; B Lipinska; D Ang; Costa Georgopoulos
Mutational analysis of the phage T4 morphogenetic 31 gene, whose product interacts with the Escherichia coli GroEL protein.
Gene 1990;86(1):19-25.
1989: A Cegielska; Costa Georgopoulos
Functional domains of the Escherichia coli dnaK heat shock protein as revealed by mutational analysis.
The Journal of biological chemistry 1989;264(35):21122-30.
1989: A Cegielska; Costa Georgopoulos
Biochemical properties of the Escherichia coli dnaK heat shock protein and its mutant derivatives.
Biochimie 1989;71(9-10):1071-7.
1989: D Ang; Costa Georgopoulos
The heat-shock-regulated grpE gene of Escherichia coli is required for bacterial growth at all temperatures but is dispensable in certain mutant backgrounds.
Journal of bacteriology 1989;171(5):2748-55.
1989: Maciej Zylicz; D Ang; Krzysztof Liberek; Costa Georgopoulos
Initiation of lambda DNA replication with purified host- and bacteriophage-encoded proteins: the role of the dnaK, dnaJ and grpE heat shock proteins.
The EMBO journal 1989;8(5):1601-8.
1989: J Spence; Costa Georgopoulos
Purification and properties of the Escherichia coli heat shock protein, HtpG.
The Journal of biological chemistry 1989;264(8):4398-403.
1989: Olivier Fayet; T Ziegelhoffer; Costa Georgopoulos
The groES and groEL heat shock gene products of Escherichia coli are essential for bacterial growth at all temperatures.
Journal of bacteriology 1989;171(3):1379-85.
1989: B Lipinska; Olivier Fayet; L Baird; Costa Georgopoulos
Identification, characterization, and mapping of the Escherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures.
Journal of bacteriology 1989;171(3):1574-84.
1989: C Johnson; G N Chandrasekhar; Costa Georgopoulos
Escherichia coli DnaK and GrpE heat shock proteins interact both in vivo and in vitro.
Journal of bacteriology 1989;171(3):1590-6.
1988: Maciej Zylicz; D Ang; Krzysztof Liberek; T Yamamoto; Costa Georgopoulos
Initiation of lambda DNA replication reconstituted with purified lambda and Escherichia coli replication proteins.
Biochimica et biophysica acta 1988;951(2-3):344-50.
1988: B Lipinska; S Sharma; Costa Georgopoulos
Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mechanism of heat-inducible transcription.
Nucleic acids research 1988;16(21):10053-67.
1988: Krzysztof Liberek; Costa Georgopoulos; Maciej Zylicz
Role of the Escherichia coli DnaK and DnaJ heat shock proteins in the initiation of bacteriophage lambda DNA replication.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6632-6.
1988: B Lipinska; J King; D Ang; Costa Georgopoulos
Sequence analysis and transcriptional regulation of the Escherichia coli grpE gene, encoding a heat shock protein.
Nucleic acids research 1988;16(15):7545-62.
1988: J Swindle; Maciej Zylicz; Costa Georgopoulos; J Li; J Greenblatt
Purification and properties of the NusB protein of Escherichia coli.
The Journal of biological chemistry 1988;263(21):10229-35.
1987: Maciej Zylicz; D Ang; Costa Georgopoulos
The grpE protein of Escherichia coli. Purification and properties.
The Journal of biological chemistry 1987;262(36):17437-42.
1987: T Yamamoto; J McIntyre; S M Sell; Costa Georgopoulos; Dorota Skowyra; Maciej Zylicz
Enzymology of the pre-priming steps in lambda dv DNA replication in vitro.
The Journal of biological chemistry 1987;262(17):7996-9.
1987: H Bahl; H Echols; D B Straus; D Court; R Crowl; Costa Georgopoulos
Induction of the heat shock response of E. coli through stabilization of sigma 32 by the phage lambda cIII protein.
Genes & development 1987;1(1):57-64.
1986: D Ang; G N Chandrasekhar; Maciej Zylicz; Costa Georgopoulos
Escherichia coli grpE gene codes for heat shock protein B25.3, essential for both lambda DNA replication at all temperatures and host growth at high temperature.
Journal of bacteriology 1986;167(1):25-9.