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Larry Gerace

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Donald E Kerkow; Elena Menichelli; Géza Ambrus; Andrew B Carmel; Larry Gerace; Ronald D Hills; James R Williamson
The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.
Larry Gerace; Michael D Huber
Nuclear lamina at the crossroads of the cytoplasm and nucleus.
Géza Ambrus; Landon R Whitby; Eric L Singer; Oleg Trott; Euna Choi; Arthur J Olson; Dale L Boger; Larry Gerace
Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport.

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All Publications

2012: Donald E Kerkow; Elena Menichelli; Géza Ambrus; Andrew B Carmel; Larry Gerace; Ronald D Hills; James R Williamson
The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.
Journal of molecular biology 2012;415(4):649-65.
2012: Larry Gerace; Michael D Huber
Nuclear lamina at the crossroads of the cytoplasm and nucleus.
Journal of structural biology 2012;177(1):24-31.
2010: Géza Ambrus; Landon R Whitby; Eric L Singer; Oleg Trott; Euna Choi; Arthur J Olson; Dale L Boger; Larry Gerace
Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport.
Bioorganic & medicinal chemistry 2010;18(21):7611-20.
2009: Michael D Huber; Tinglu Guan; Larry Gerace
Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation.
Molecular and cellular biology 2009;29(21):5718-28.
2009: Guang-Hui Liu; Tinglu Guan; Kaustuv Datta; Judith A Coppinger; John Yates; Larry Gerace
Regulation of myoblast differentiation by the nuclear envelope protein NET39.
Molecular and cellular biology 2009;29(21):5800-12.
2009: Kaustuv Datta; Tinglu Guan; Larry Gerace
NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation.
The Journal of biological chemistry 2009;284(43):29666-76.
2009: Iris Ben-Efraim; Phyllis Frosst; Larry Gerace
Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr.
BMC cell biology 2009;10():74.
2009: Guang-Hui Liu; Larry Gerace
Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.
PloS one 2009;4(9):e7031.
2009: Aurelia Cassany; Larry Gerace
Reconstitution of nuclear import in permeabilized cells.
Methods in molecular biology (Clifton, N.J.) 2009;464():181-205.
2008: Jason G Smith; Aurelia Cassany; Larry Gerace; Robert Ralston; Glen R Nemerow
Neutralizing antibody blocks adenovirus infection by arresting microtubule-dependent cytoplasmic transport.
Journal of virology 2008;82(13):6492-500.
2008: Stephen P Edgcomb; Angelique Aschrafi; Elizabeth Kompfner; James R Williamson; Larry Gerace; Mirko Hennig
Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes.
Protein science : a publication of the Protein Society 2008;17(3):420-30.
2007: Michael D Huber; Larry Gerace
The size-wise nucleus: nuclear volume control in eukaryotes.
The Journal of cell biology 2007;179(4):583-4.
2006: Harald Wodrich; Aurelia Cassany; Maximiliano A D'Angelo; Tinglu Guan; Glen R Nemerow; Larry Gerace
Adenovirus core protein pVII is translocated into the nucleus by multiple import receptor pathways.
Journal of virology 2006;80(19):9608-18.
2006: I-Hsiung Brandon Chen; Michael Huber; Tinglu Guan; Anja Bubeck; Larry Gerace
Nuclear envelope transmembrane proteins (NETs) that are up-regulated during myogenesis.
BMC cell biology 2006;7():38.
2005: Eric C Schirmer; Larry Gerace
The nuclear membrane proteome: extending the envelope.
Trends in biochemical sciences 2005;30(10):551-8.
2005: Jason K Ospina; Graydon B Gonsalvez; Janna Bednenko; Edward Darzynkiewicz; Larry Gerace; A Gregory Matera
Cross-talk between snurportin1 subdomains.
Molecular biology of the cell 2005;16(10):4660-71.
2005: Christopher M Wiethoff; Harald Wodrich; Larry Gerace; Glen R Nemerow
Adenovirus protein VI mediates membrane disruption following capsid disassembly.
Journal of virology 2005;79(4):1992-2000.
2005: Eric C Schirmer; Laurence Florens; Tinglu Guan; John R Yates; Larry Gerace
Identification of novel integral membrane proteins of the nuclear envelope with potential disease links using subtractive proteomics.
Novartis Foundation symposium 2005;264():63-76; discussion 76-80, 227-30.
2004: Tomoyuki Ohba; Eric C Schirmer; Takeharu Nishimoto; Larry Gerace
Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore.
The Journal of cell biology 2004;167(6):1051-62.
2004: Eric C Schirmer; Larry Gerace
The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths.
The Journal of biological chemistry 2004;279(41):42811-7.
2004: Larry Gerace
TorsinA and torsion dystonia: Unraveling the architecture of the nuclear envelope.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):8839-40.
2004: Iris Ben-Efraim; Quansheng Zhou; Therese Wiedmer; Larry Gerace; Peter J Sims
Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA.
Biochemistry 2004;43(12):3518-26.
2003: Harald Wodrich; Tinglu Guan; Gino Cingolani; Dan J Von Seggern; Glen R Nemerow; Larry Gerace
Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals.
The EMBO journal 2003;22(23):6245-55.
2003: Eric C Schirmer; John R Yates; Larry Gerace
MudPIT: A powerful proteomics tool for discovery.
Discovery medicine 2003;3(18):38-9.
2003: Eric C Schirmer; Laurence Florens; Tinglu Guan; John R Yates; Larry Gerace
Nuclear membrane proteins with potential disease links found by subtractive proteomics.
Science (New York, N.Y.) 2003;301(5638):1380-2.
2003: Janna Bednenko; Gino Cingolani; Larry Gerace
Importin beta contains a COOH-terminal nucleoporin binding region important for nuclear transport.
The Journal of cell biology 2003;162(3):391-401.
2003: Carolin Koerner; Tinglu Guan; Larry Gerace; Gino Cingolani
Synergy of silent and hot spot mutations in importin beta reveals a dynamic mechanism for recognition of a nuclear localization signal.
The Journal of biological chemistry 2003;278(18):16216-21.
2003: Janna Bednenko; Gino Cingolani; Larry Gerace
Nucleocytoplasmic transport: navigating the channel.
Traffic (Copenhagen, Denmark) 2003;4(3):127-35.
2002: Gino Cingolani; Janna Bednenko; Matthew T Gillespie; Larry Gerace
Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.
Molecular cell 2002;10(6):1345-53.
2002: Susan K Lyman; Tinglu Guan; Janna Bednenko; Harald Wodrich; Larry Gerace
Influence of cargo size on Ran and energy requirements for nuclear protein import.
The Journal of cell biology 2002;159(1):55-67.
2002: Phyllis Frosst; Tinglu Guan; Cecilia Subauste; Klaus M Hahn; Larry Gerace
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export.
The Journal of cell biology 2002;156(4):617-30.
2002: Ralph H Kehlenbach; Larry Gerace
Analysis of nuclear protein import and export in vitro using fluorescent cargoes.
Methods in molecular biology (Clifton, N.J.) 2002;189():231-45.
2002: Eric C Schirmer; Larry Gerace
Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope.
Genome biology 2002;3(4):REVIEWS1008.
2001: I Schmitt; Larry Gerace
In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap.
The Journal of biological chemistry 2001;276(45):42355-63.
2001: S K Lyman; Larry Gerace
Nuclear pore complexes: dynamics in unexpected places.
The Journal of cell biology 2001;154(1):17-20.
2001: Eric C Schirmer; Tinglu Guan; Larry Gerace
Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization.
The Journal of cell biology 2001;153(3):479-89.
2001: Ralph H Kehlenbach; R Assheuer; A Kehlenbach; J Becker; Larry Gerace
Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.
The Journal of biological chemistry 2001;276(17):14524-31.
2001: Iris Ben-Efraim; Larry Gerace
Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import.
The Journal of cell biology 2001;152(2):411-7.
2000: Gino Cingolani; Hilal A Lashuel; Larry Gerace; Christoph W Müller
Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association.
FEBS letters 2000;484(3):291-8.
2000: Tinglu Guan; Ralph H Kehlenbach; Eric C Schirmer; A Kehlenbach; F Fan; B E Clurman; Norman Arnheim; Larry Gerace
Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export.
Molecular and cellular biology 2000;20(15):5619-30.
2000: Ralph H Kehlenbach; Larry Gerace
Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro.
The Journal of biological chemistry 2000;275(23):17848-56.
2000: Andrew C S Saphire; Tinglu Guan; Eric C Schirmer; Glen R Nemerow; Larry Gerace
Nuclear import of adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70.
The Journal of biological chemistry 2000;275(6):4298-304.
1999: S K Lyman; Larry Gerace; Susan J. Baserga
Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins.
RNA (New York, N.Y.) 1999;5(12):1597-604.
1999: Ralph H Kehlenbach; A Dickmanns; A Kehlenbach; Tinglu Guan; Larry Gerace
A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export.
The Journal of cell biology 1999;145(4):645-57.
1998: Andrew C S Saphire; Steven J Bark; Larry Gerace
All four homochiral enantiomers of a nuclear localization sequence derived from c-Myc serve as functional import signals.
The Journal of biological chemistry 1998;273(45):29764-9.
1998: T Hu; Larry Gerace
cDNA cloning and analysis of the expression of nucleoporin p45.
Gene 1998;221(2):245-53.
1998: Ralph H Kehlenbach; A Dickmanns; Larry Gerace
Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro.
The Journal of cell biology 1998;141(4):863-74.
1998: F Melchior; Larry Gerace
Two-way trafficking with Ran.
Trends in cell biology 1998;8(5):175-9.
1998: K Furukawa; C E Fritze; Larry Gerace
The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain.
The Journal of biological chemistry 1998;273(7):4213-9.
1998: J M Westendorf; K N Konstantinov; Steven Wormsley; M D Shu; N Matsumoto-Taniura; Fabienne Pirollet; F G Klier; Larry Gerace; Susan J. Baserga
M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component.
Molecular biology of the cell 1998;9(2):437-49.
1998: R Mahajan; Larry Gerace; F Melchior
Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association.
The Journal of cell biology 1998;140(2):259-70.
1997: C Delphin; Tinglu Guan; F Melchior; Larry Gerace
RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex.
Molecular biology of the cell 1997;8(12):2379-90.
1997: L Yang; Tinglu Guan; Larry Gerace
Lamin-binding fragment of LAP2 inhibits increase in nuclear volume during the cell cycle and progression into S phase.
The Journal of cell biology 1997;139(5):1077-87.
1997: W D Clarkson; Anita H Corbett; Bryce M Paschal; Helen M Kent; Airlie J McCoy; Larry Gerace; P A Silver; Murray Stewart
Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran.
Journal of molecular biology 1997;272(5):716-30.
1997: Bryce M Paschal; C Fritze; Tinglu Guan; Larry Gerace
High levels of the GTPase Ran/TC4 relieve the requirement for nuclear protein transport factor 2.
The Journal of biological chemistry 1997;272(34):21534-9.
1997: L Yang; Tinglu Guan; Larry Gerace
Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis.
The Journal of cell biology 1997;137(6):1199-210.
1997: R Mahajan; C Delphin; Tinglu Guan; Larry Gerace; F Melchior
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
Cell 1997;88(1):97-107.
1996: K Konstantinov; A von Mikecz; D Buchwald; J Jones; Larry Gerace; Eng M Tan
Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.
The Journal of clinical investigation 1996;98(8):1888-96.
1996: N Matsumoto-Taniura; Fabienne Pirollet; R Monroe; Larry Gerace; J M Westendorf
Identification of novel M phase phosphoproteins by expression cloning.
Molecular biology of the cell 1996;7(9):1455-69.
1996: T Hu; Tinglu Guan; Larry Gerace
Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins.
The Journal of cell biology 1996;134(3):589-601.
1996: Bryce M Paschal; C Delphin; Larry Gerace
Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7679-83.
1996: D J Sweet; Larry Gerace
A GTPase distinct from Ran is involved in nuclear protein import.
The Journal of cell biology 1996;133(5):971-83.
1995: D J Sweet; Larry Gerace
Taking from the cytoplasm and giving to the pore: soluble transport factors in nuclear protein import.
Trends in cell biology 1995;5(12):444-7.
1995: Tinglu Guan; S Müller; G Klier; N Panté; J M Blevitt; M Haner; Bryce M Paschal; U Aebi; Larry Gerace
Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex.
Molecular biology of the cell 1995;6(11):1591-603.
1995: F Melchior; Tinglu Guan; N Yokoyama; T Nishimoto; Larry Gerace
GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import.
The Journal of cell biology 1995;131(3):571-81.
1995: H Taniura; C Glass; Larry Gerace
A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones.
The Journal of cell biology 1995;131(1):33-44.
1995: Larry Gerace
Nuclear export signals and the fast track to the cytoplasm.
Cell 1995;82(3):341-4.
1995: F Melchior; Larry Gerace
Mechanisms of nuclear protein import.
Current opinion in cell biology 1995;7(3):310-8.
1995: Bryce M Paschal; Larry Gerace
Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.
The Journal of cell biology 1995;129(4):925-37.
1995: Koichi Furukawa; N Panté; U Aebi; Larry Gerace
Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope.
The EMBO journal 1995;14(8):1626-36.
1995: L Martin; C Crimaudo; Larry Gerace
cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane.
The Journal of biological chemistry 1995;270(15):8822-8.
1995: F Melchior; Tinglu Guan; Bryce M Paschal; Larry Gerace
Biochemical and structural analysis of nuclear protein import.
Cold Spring Harbor symposia on quantitative biology 1995;60():707-16.
1995: F Melchior; D J Sweet; Larry Gerace
Analysis of Ran/TC4 function in nuclear protein import.
Methods in enzymology 1995;257():279-91.
1995: U F Greber; Larry Gerace
Depletion of calcium from the lumen of endoplasmic reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus.
The Journal of cell biology 1995;128(1-2):5-14.
1995: K Konstantinov; R Foisner; D Byrd; Fu-Tong Liu; W M Tsai; Allan Wiik; Larry Gerace
Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope.
Clinical immunology and immunopathology 1995;74(1):89-99.
1994: D A Byrd; D J Sweet; N Panté; K N Konstantinov; Tinglu Guan; Andrew C S Saphire; P J Mitchell; C S Cooper; U Aebi; Larry Gerace
Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.
The Journal of cell biology 1994;127(6 Pt 1):1515-26.
1994: Larry Gerace; R Foisner
Integral membrane proteins and dynamic organization of the nuclear envelope.
Trends in cell biology 1994;4(4):127-31.
1994: J M Westendorf; P N Rao; Larry Gerace
Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):714-8.
1993: F Melchior; Bryce M Paschal; J Evans; Larry Gerace
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.
The Journal of cell biology 1993;123(6 Pt 2):1649-59.
1993: C A Glass; J R Glass; H Taniura; Chuck Hasel; J M Blevitt; Larry Gerace
The alpha-helical rod domain of human lamins A and C contains a chromatin binding site.
The EMBO journal 1993;12(11):4413-24.
1993: R Foisner; Larry Gerace
Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation.
Cell 1993;73(7):1267-79.
1992: R Sterne-Marr; J M Blevitt; Larry Gerace
O-linked glycoproteins of the nuclear pore complex interact with a cytosolic factor required for nuclear protein import.
The Journal of cell biology 1992;116(2):271-80.
1992: Stephen Adam; R Sterne-Marr; Larry Gerace
Nuclear protein import using digitonin-permeabilized cells.
Methods in enzymology 1992;219():97-110.
1992: U F Greber; Larry Gerace
Nuclear protein import is inhibited by an antibody to a lumenal epitope of a nuclear pore complex glycoprotein.
The Journal of cell biology 1992;116(1):15-30.
1991: J B Millar; J Blevitt; Larry Gerace; K Sadhu; C Featherstone; Paul Russell
p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10500-4.
1991: Stephen Adam; Larry Gerace
Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import.
Cell 1991;66(5):837-47.
1991: Stephen Adam; R Sterne-Marr; Larry Gerace
In vitro nuclear protein import using permeabilized mammalian cells.
Methods in cell biology 1991;35():469-82.
1990: Stephen Adam; R S Marr; Larry Gerace
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.
The Journal of cell biology 1990;111(3):807-16.
1990: J R Glass; Larry Gerace
Lamins A and C bind and assemble at the surface of mitotic chromosomes.
The Journal of cell biology 1990;111(3):1047-57.
1990: U F Greber; A Senior; Larry Gerace
A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail.
The EMBO journal 1990;9(5):1495-502.
1989: Stephen Adam; T J Lobl; Mark Mitchell; Larry Gerace
Identification of specific binding proteins for a nuclear location sequence.
Nature 1989;337(6204):276-9.
1988: A Senior; Larry Gerace
Integral membrane proteins specific to the inner nuclear membrane and associated with the nuclear lamina.
The Journal of cell biology 1988;107(6 Pt 1):2029-36.
1988: C Featherstone; M K Darby; Larry Gerace
A monoclonal antibody against the nuclear pore complex inhibits nucleocytoplasmic transport of protein and RNA in vivo.
The Journal of cell biology 1988;107(4):1289-97.
1988: Larry Gerace; B Burke
Functional organization of the nuclear envelope.
Annual review of cell biology 1988;4():335-74.