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Mark Geraci

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TOP 3
Mark W Geraci
Integrating molecular genetics and systems approaches to pulmonary vascular diseases.
Abigail R Lara; Hakan Sahin; Marvin I Schwarz; Rubin M Tuder; Tristan J Huie; Dallas M Hyde; William J Janssen; Ellen L Burnham; Carlyne D Cool; Gregory P Cosgrove; Douglas Curran-Everett; Mark W Geraci; Steve D Groshong; David E Heinz; Peter M Henson
Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia.
Christina A Meadows; Michael Risbano; Li Zhang; Mark W Geraci; Rubin M Tuder; David H Collier; Todd M Bull
Increased expression of growth differentiation factor-15 in systemic sclerosis-associated pulmonary arterial hypertension.

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All Publications

2013: Mark W Geraci
Integrating molecular genetics and systems approaches to pulmonary vascular diseases.
Pulmonary circulation 2013;3(1):171-5.
2012: Abigail R Lara; Hakan Sahin; Marvin I Schwarz; Rubin M Tuder; Tristan J Huie; Dallas M Hyde; William J Janssen; Ellen L Burnham; Carlyne D Cool; Gregory P Cosgrove; Douglas Curran-Everett; Mark W Geraci; Steve D Groshong; David E Heinz; Peter M Henson
Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia.
Chest 2012;142(6):1569-76.
2011: Christina A Meadows; Michael Risbano; Li Zhang; Mark W Geraci; Rubin M Tuder; David H Collier; Todd M Bull
Increased expression of growth differentiation factor-15 in systemic sclerosis-associated pulmonary arterial hypertension.
Chest 2011;139(5):994-1002.
2010: Micheala A Aldred; Suzy A Comhair; Marileila Varella-Garcia; Kewal Asosingh; Weiling Xu; George P Noon; Patricia A Thistlethwaite; Rubin M Tuder; Serpil C Erzurum; Mark W Geraci; Christopher Coldren
Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2010;182(9):1153-60.
2010: David C Calverley; Tzu L Phang; Qamrul G Choudhury; Bifeng Gao; Ana B Oton; Michael J Weyant; Mark W Geraci
Significant downregulation of platelet gene expression in metastatic lung cancer.
Clinical and translational science 2010;3(5):227-32.
2010: Michael G Risbano; Christina A Meadows; Christopher D Coldren; Tiffany J Jenkins; Michael G Edwards; David Collier; Wendy Huber; Douglas G Mack; Andrew P Fontenot; Mark W Geraci; Todd M Bull
Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension.
Clinical and translational science 2010;3(5):210-8.
2010: Mark W Geraci; Todd M Bull; Rubin M Tuder
Genomics of pulmonary arterial hypertension: implications for therapy.
Heart failure clinics 2010;6(1):101-14.
2009: Derek Strassheim; Suzzette R Riddle; Danielle L Burke; Mark W Geraci; Kurt R Stenmark
Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):6981-8.
2009: Mary C M Weiser-Evans; Xue-Qing Wang; Jay Amin; Vicki Van Putten; Rashmi Choudhary; Robert A Winn; Robert Scheinman; Peter Simpson; Mark W Geraci; Raphael A Nemenoff
Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis.
Cancer research 2009;69(5):1733-8.
2009: John Arcaroli; John E Hokanson; Edward Abraham; Mark W Geraci; James R Murphy; Russell P Bowler; Charles A Dinarello; Lori Silveira; Jeff Sankoff; Daren Heyland; Paul E Wischmeyer; James D Crapo
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.
American journal of respiratory and critical care medicine 2009;179(2):105-12.
2008: Todd M Bull; Christina A Meadows; Christopher Coldren; Mark Moore; Sylk M Sotto-Santiago; Serge P Nana-Sinkam; Thomas B Campbell; Mark W Geraci
Human herpesvirus-8 infection of primary pulmonary microvascular endothelial cells.
American journal of respiratory cell and molecular biology 2008;39(6):706-16.
2008: Milene T Saavedra; Grant J Hughes; Linda A Sanders; Michelle Carr; David M Rodman; Christopher Coldren; Mark W Geraci; Scott D Sagel; Frank J Accurso; James West; Jerry A Nick
Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease.
American journal of respiratory and critical care medicine 2008;178(9):929-38.
2008: Raphael A Nemenoff; Amy M Meyer; Tyler M Hudish; Anthony B Mozer; Amy Snee; Shuh Narumiya; Robert Stearman; Robert A Winn; Mary C M Weiser-Evans; Mark W Geraci; Robert L Keith
Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma.
Cancer prevention research (Philadelphia, Pa.) 2008;1(5):349-56.
2008: Robert Stearman; Lori D Dwyer-Nield; Michael C Grady; Alvin M Malkinson; Mark W Geraci
A macrophage gene expression signature defines a field effect in the lung tumor microenvironment.
Cancer research 2008;68(1):34-43.
2007: Brian D Lowes; Ronald Zolty; Simon F Shakar; Andreas Brieke; Norman Gray; Michael Reed; Mihail Calalb; Wayne A Minobe; JoAnn Lindenfeld; Eugene E Wolfel; Mark W Geraci; Michael R Bristow; Joseph Cleveland
Assist devices fail to reverse patterns of fetal gene expression despite beta-blockers.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007;26(11):1170-6.
2007: Wei Wang; Einath Zolty; Sandor Falk; Sandra N Summer; Robert Stearman; Mark W Geraci; Robert W Schrier
Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice.
American journal of physiology. Renal physiology 2007;293(4):F1131-6.
2007: S Patrick Nana-Sinkam; Jong Deog Lee; Sylk Sotto-Santiago; Robert Stearman; Robert L Keith; Qamrul Choudhury; Carlyne D Cool; Jane E Parr; Mark D Moore; Todd M Bull; Norbert F Voelkel; Mark W Geraci
Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke.
American journal of respiratory and critical care medicine 2007;175(7):676-85.
2007: Robert Stearman; Michael C Grady; Patrick Nana-Sinkam; Marileila Varella-Garcia; Mark W Geraci
Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.
Molecular cancer research : MCR 2007;5(3):295-308.
2007: Todd M Bull; Christopher Coldren; Mark W Geraci; Norbert F Voelkel
Gene expression profiling in pulmonary hypertension.
Proceedings of the American Thoracic Society 2007;4(1):117-20.
2006: Christopher Coldren; Jerry A Nick; Katie R Poch; Malcolm D Woolum; Brian W Fouty; James O'Brien; Michael P Gruber; Martin R Zamora; Daiva Svetkauskaite; Don A Richter; Qianbin He; Jong Sung Park; Katherine H Overdier; Edward Abraham; Mark W Geraci
Functional and genomic changes induced by alveolar transmigration in human neutrophils.
American journal of physiology. Lung cellular and molecular physiology 2006;291(6):L1267-76.
2006: S Patrick Nana-Sinkam; Mark W Geraci
MicroRNA in lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9):929-31.
2006: S Patrick Nana-Sinkam; Jong Deog Lee; Robert Stearman; Seiichiro Sakao; Sylk Sotto-Santiago; Norbert F Voelkel; Mark W Geraci
Prostacyclin synthase in smoking-related lung disease.
Proceedings of the American Thoracic Society 2006;3(6):517.
2006: Christopher Coldren; Barbara Helfrich; Samir E Witta; Michio Sugita; Razvan Lapadat; Chan Zeng; Anna E Barón; Wilbur A Franklin; Fred R Hirsch; Mark W Geraci; Paul A Bunn
Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.
Molecular cancer research : MCR 2006;4(8):521-8.
2006: Robert L Keith; Mark W Geraci
Prostacyclin in lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(6):503-5.
2006: Robert L Keith; Mark W Geraci; S Patrick Nana-Sinkam; Richard M Breyer; Tyler M Hudish; Amy M Meyer; Alvin M Malkinson; Lori D Dwyer-Nield
Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis.
Anticancer research 2006;26(4B):2857-61.
2006: Michael P Gruber; Christopher Coldren; Malcolm D Woolum; Gregory P Cosgrove; Chan Zeng; Anna E Barón; Mark D Moore; Carlyne D Cool; G Scott Worthen; Kevin K Brown; Mark W Geraci
Human lung project: evaluating variance of gene expression in the human lung.
American journal of respiratory cell and molecular biology 2006;35(1):65-71.
2006: Amy M Meyer; Lori D Dwyer-Nield; Greg Hurteau; Robert L Keith; Yanli Ouyang; Brian M Freed; Lori R Kisley; Mark W Geraci; Joseph V Bonventre; Raphael A Nemenoff; Alvin M Malkinson
Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice.
American journal of physiology. Lung cellular and molecular physiology 2006;290(6):L1260-6.
2005: Patrick Nana-Sinkam; Ryan J Oyer; Robert Stearman; Sylk Sotto-Santiago; Mark D Moore; Todd M Bull; Michael C Grady; Q Choudhery; Raphael A Nemenoff; Kirk Lane; James E Loyd; Mark W Geraci
Prostacyclin synthase promoter regulation and familial pulmonary arterial hypertension.
Chest 2005;128(6 Suppl):612S.
2005: Todd M Bull; Christopher Coldren; Patrick Nana-Sinkam; Sylk Sotto-Santiago; Mark Moore; Norbert F Voelkel; Mark W Geraci
Microarray analysis of peripheral blood cells in pulmonary arterial hypertension, surrogate to biopsy.
Chest 2005;128(6 Suppl):584S.
2005: Jong Deog Lee; Laimute Taraseviciene-Stewart; Robert L Keith; Mark W Geraci; Norbert F Voelkel
The expression of prostacyclin synthase is decreased in the small pulmonary arteries from patients with emphysema.
Chest 2005;128(6 Suppl):575S.
2005: Robert Stearman; Lori D Dwyer-Nield; Laura K Zerbe; Stacy A Blaine; Zeng Chan; Paul A Bunn; Gary L Johnson; Fred R Hirsch; Daniel T Merrick; Wilbur A Franklin; Anna E Baron; Robert L Keith; Raphael A Nemenoff; Alvin M Malkinson; Mark W Geraci
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.
The American journal of pathology 2005;167(6):1763-75.
2005: Yvette Bren-Mattison; Vicki Van Putten; Daniel Chan; Robert Winn; Mark W Geraci; Raphael A Nemenoff
Peroxisome proliferator-activated receptor-gamma (PPAR(gamma)) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC).
Oncogene 2005;24(8):1412-22.
2005: Michael P Gruber; Mark W Geraci
Practical cancer genetics, genomics and proteomics.
Journal of insurance medicine (New York, N.Y.) 2005;37(3):190-200.
2005: Stacy A Blaine; Amy M Meyer; Greg Hurteau; Marilee Wick; Joseph A Hankin; Robert C Murphy; Andrew J Dannenberg; Mark W Geraci; Kotha Subbaramaiah; Raphael A Nemenoff
Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice.
Carcinogenesis 2005;26(1):209-17.
2004: Jerry A Nick; Christopher Coldren; Mark W Geraci; Katie R Poch; Brian W Fouty; James O'Brien; Michael Gruber; Simona Zarini; Robert C Murphy; Katherine Kuhn; Don Richter; Kelly R Kast; Edward Abraham
Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis.
Blood 2004;104(13):3878-85.
2004: Heiko A Golpon; Christopher Coldren; Martin R Zamora; Gregory P Cosgrove; Mark D Moore; Rubin M Tuder; Mark W Geraci; Norbert F Voelkel
Emphysema lung tissue gene expression profiling.
American journal of respiratory cell and molecular biology 2004;31(6):595-600.
2004: Todd M Bull; Christopher Coldren; Mark Moore; Sylk Sotto-Santiago; David V Pham; S Patrick Nana-Sinkam; Norbert F Voelkel; Mark W Geraci
Gene microarray analysis of peripheral blood cells in pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2004;170(8):911-9.
2004: Robert L Keith; York E Miller; Tyler M Hudish; Carlos E Girod; Sylk Sotto-Santiago; Wilbur A Franklin; Raphael A Nemenoff; Thomas H March; S Patrick Nana-Sinkam; Mark W Geraci
Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice.
Cancer research 2004;64(16):5897-904.
2004: Gregory P Cosgrove; Kevin K Brown; William P Schiemann; Amanda E Serls; Jane E Parr; Mark W Geraci; Marvin I Schwarz; Carlyne D Cool; G Scott Worthen
Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis.
American journal of respiratory and critical care medicine 2004;170(3):242-51.
2004: Patrick Nana-Sinkam; Heiko A Golpon; Robert L Keith; Ryan J Oyer; Sylk Sotto-Santiago; Mark D Moore; Wilbur Franklin; Raphael A Nemenoff; Mark W Geraci
Prostacyclin in human non-small cell lung cancers.
Chest 2004;125(5 Suppl):141S.
2003: Todd M Bull; Heiko A Golpon; Robert P Hebbel; Anna Solovey; Carlyne D Cool; Rubin M Tuder; Mark W Geraci; Norbert F Voelkel
Circulating endothelial cells in pulmonary hypertension.
Thrombosis and haemostasis 2003;90(4):698-703.
2003: Carlyne D Cool; Pradeep R Rai; Michael E Yeager; Daniel Hernandez-Saavedra; Amanda E Serls; Todd M Bull; Mark W Geraci; Kevin K Brown; John Routes; Rubin M Tuder; Norbert F Voelkel
Expression of human herpesvirus 8 in primary pulmonary hypertension.
The New England journal of medicine 2003;349(12):1113-22.
2003: Todd M Bull; Carlyne D Cool; Amanda E Serls; Pradeep R Rai; Jane E Parr; James M Neid; Mark W Geraci; Thomas B Campbell; Norbert F Voelkel; David B Badesch
Primary pulmonary hypertension, Castleman's disease and human herpesvirus-8.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(3):403-7.
2003: Shingo Ameshima; Heiko A Golpon; Carlyne D Cool; Daniel Chan; R William Vandivier; Shyra J Gardai; Marilee Wick; Raphael A Nemenoff; Mark W Geraci; Norbert F Voelkel
Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth.
Circulation research 2003;92(10):1162-9.
2003: Yasushi Hoshikawa; Patrick Nana-Sinkam; Mark D Moore; Sylk Sotto-Santiago; Tzu Lip Phang; Robert L Keith; Kenneth G Morris; Takashi Kondo; Rubin M Tuder; Norbert F Voelkel; Mark W Geraci
Hypoxia induces different genes in the lungs of rats compared with mice.
Physiological genomics 2003;12(3):209-19.
2002: Marilee Wick; Greg Hurteau; Christina Dessev; Daniel Chan; Mark W Geraci; Robert A Winn; Lynn E Heasley; Raphael A Nemenoff
Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth.
Molecular pharmacology 2002;62(5):1207-14.
2002: Michio Sugita; Mark W Geraci; Bifeng Gao; Roger L Powell; Fred R Hirsch; Gary L Johnson; Razvan Lapadat; Edward Gabrielson; Roy M Bremnes; Paul A Bunn; Wilbur A Franklin
Combined use of oligonucleotide and tissue microarrays identifies cancer/testis antigens as biomarkers in lung carcinoma.
Cancer research 2002;62(14):3971-9.
2002: Norbert F Voelkel; Carlyne D Cool; Laima Taraceviene-Stewart; Mark W Geraci; Michael Yeager; Todd M Bull; Michael Kasper; Rubin M Tuder
Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension.
Critical care medicine 2002;30(5 Suppl):S251-6.
2002: Mark W Geraci; Yasushi Hoshikawa; Michael Yeager; Heiko A Golpon; Tracy L Gesell; Rubin M Tuder; Norbert F Voelkel
Gene expression profiles in pulmonary hypertension.
Chest 2002;121(3 Suppl):104S-105S.
2002: Gregory P Cosgrove; Marvin I Schwarz; Mark W Geraci; Kevin K Brown; G Scott Worthen
Overexpression of matrix metalloproteinase-7 in pulmonary fibrosis.
Chest 2002;121(3 Suppl):25S-26S.
2002: Robert L Keith; York E Miller; Yasushi Hoshikawa; Mark D Moore; Tracy L Gesell; Bifeng Gao; Alvin M Malkinson; Heiko A Golpon; Raphael A Nemenoff; Mark W Geraci
Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer.
Cancer research 2002;62(3):734-40.
2002: Aaron C Spalding; Robert M Jotte; Robert I Scheinman; Mark W Geraci; Penny Clarke; Kenneth L Tyler; Gary L Johnson
TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells.
Oncogene 2002;21(2):260-71.
2001: Rubin M Tuder; M Chacon; LA Alger; Jian Wang; Laimute Taraseviciene-Stewart; Yasunori Kasahara; Carlyne D Cool; A E Bishop; Mark W Geraci; Gregg L Semenza; M Yacoub; J M Polak; Norbert F Voelkel
Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis.
The Journal of pathology 2001;195(3):367-74.
2001: Thomas A Parker; Sam Afshar; John P Kinsella; Theresa R Grover; Sarah A Gebb; Mark W Geraci; Philip W Shaul; C M Cryer; Steven H Abman
Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H1005-14.
2001: Yasushi Hoshikawa; Norbert F Voelkel; Tracy L Gesell; Mark D Moore; Kenneth G Morris; LA Alger; S Narumiya; Mark W Geraci
Prostacyclin receptor-dependent modulation of pulmonary vascular remodeling.
American journal of respiratory and critical care medicine 2001;164(2):314-8.
2001: Rubin M Tuder; Michael E Yeager; Mark W Geraci; Heiko A Golpon; Norbert F Voelkel
Severe pulmonary hypertension after the discovery of the familial primary pulmonary hypertension gene.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(6):1065-9.
2001: Mark W Geraci; M Moore; Tracy L Gesell; Michael E Yeager; LA Alger; Heiko A Golpon; Bifeng Gao; J E Loyd; Rubin M Tuder; Norbert F Voelkel
Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis.
Circulation research 2001;88(6):555-62.
2001: Heiko A Golpon; Mark W Geraci; Mark D Moore; Heidi L Miller; Gary J Miller; Rubin M Tuder; Norbert F Voelkel
HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema.
The American journal of pathology 2001;158(3):955-66.
2001: Mark W Geraci; Bifeng Gao; Y Hoshikawa; Michael E Yeager; Rubin M Tuder; Norbert F Voelkel
Genomic approaches to research in pulmonary hypertension.
Respiratory research 2001;2(4):210-5.
1999: C E Girod; D H Shin; Mark W Geraci; H B Warren; L G Dobbs; Bifeng Gao; J S Rainer; Alison K Bauer; Machiko Ikegami; J M Shannon; York E Miller
Surfactant protein C promoter-driven expression of T1-alpha induces lung inflammation.
Chest 1999;116(1 Suppl):61S.
1999: Mark W Geraci; Bifeng Gao; D C Shepherd; Mark D Moore; Jay Y Westcott; Karen A Fagan; LA Alger; Rubin M Tuder; Norbert F Voelkel
Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension.
The Journal of clinical investigation 1999;103(11):1509-15.
1999: Rubin M Tuder; Carlyne D Cool; Mark W Geraci; Jian Wang; Steven H Abman; L Wright; David B Badesch; Norbert F Voelkel
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension.
American journal of respiratory and critical care medicine 1999;159(6):1925-32.
1998: Norbert F Voelkel; Carlyne D Cool; S D Lee; L Wright; Mark W Geraci; Rubin M Tuder
Primary pulmonary hypertension between inflammation and cancer.
Chest 1998;114(3 Suppl):225S-230S.
1998: Mark W Geraci; Bifeng Gao; D Shepherd; J Allard; D Curiel; Jay Y Westcott; Norbert F Voelkel
Pulmonary prostacyclin synthase overexpression by adenovirus transfection and in transgenic mice.
Chest 1998;114(1 Suppl):99S.
1998: D C Chan; Mark W Geraci; P A Bunn
Anti-growth factor therapy for lung cancer.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 1998;1(6):377-88.
1997: Mark W Geraci; D Shepherd; Mark Moore; J Vernon; J Allard; J Shannon; Norbert F Voelkel
Rat prostacyclin synthase. Cloning and regulation of gene expression in the lung.
Chest 1997;111(6 Suppl):129S.
1994: Mark W Geraci; York E Miller; A Escobedo-Morse; M A Kane
Novel bombesin-like peptide binding proteins from lung.
American journal of respiratory cell and molecular biology 1994;10(3):331-8.