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Rita Gerardy-Schahn

Research Profile

Chemicals & Drugs

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Genes & Molecular Sequences

Amino Acid Sequences

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Cloning, Molecular

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Glycosylation

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Publications

TOP 3
Martina Mühlenhoff; Manuela Rollenhagen; Sebastian Werneburg; Rita Gerardy-Schahn; Herbert Hildebrandt
Polysialic Acid: Versatile Modification of NCAM, SynCAM 1 and Neuropilin-2.
Timothy G Keys; Hazel L S Fuchs; Sebastian P Galuska; Rita Gerardy-Schahn; Friedrich Freiberger
A single amino acid toggles Escherichia coli polysialyltransferases between mono- and bifunctionality.
Angela Romanow; Katharina Stummeyer; Ulrich Vogel; Mark von Itzstein; Andrea Bethe; Heike Claus; Thomas Haselhorst; Martina Mühlenhoff; Rita Gerardy-Schahn
Biochemical and biophysical characterization of the sialyl-/hexosyltransferase synthesizing the meningococcal serogroup w135 heteropolysaccharide capsule.

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All Publications

2013: Martina Mühlenhoff; Manuela Rollenhagen; Sebastian Werneburg; Rita Gerardy-Schahn; Herbert Hildebrandt
Polysialic Acid: Versatile Modification of NCAM, SynCAM 1 and Neuropilin-2.
Neurochemical research 2013;38(6):1134-43.
2013: Timothy G Keys; Hazel L S Fuchs; Sebastian P Galuska; Rita Gerardy-Schahn; Friedrich Freiberger
A single amino acid toggles Escherichia coli polysialyltransferases between mono- and bifunctionality.
Glycobiology 2013;23(5):613-8.
2013: Angela Romanow; Katharina Stummeyer; Ulrich Vogel; Mark von Itzstein; Andrea Bethe; Heike Claus; Thomas Haselhorst; Martina Mühlenhoff; Rita Gerardy-Schahn
Biochemical and biophysical characterization of the sialyl-/hexosyltransferase synthesizing the meningococcal serogroup w135 heteropolysaccharide capsule.
The Journal of biological chemistry 2013;288(17):11718-30.
2013: Jana Führing; Sebastian Damerow; Roman Fedorov; Anja-Katharina Münster-Kühnel; Julia Schneider; Rita Gerardy-Schahn
Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase.
Glycobiology 2013;23(4):426-37.
2013: Angel Ashikov; Falk F R Buettner; Rita Gerardy-Schahn; Birgit Tiemann; Hans Bakker
LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE.
Glycobiology 2013;23(3):303-9.
2013: Simon Edvardson; Anna-Maria Baumann; Rita Gerardy-Schahn; Liqun He; Andreas W Kuss; Martina Mühlenhoff; Avraham Shaag; Oliver Stephan; Raimo Tanzi; Shamir Zenvirt; Orly Elpeleg
West syndrome caused by ST3Gal-III deficiency.
Epilepsia 2013;54(2):e24-7.
2013: Myriam Elschami; Brigitte Philippens; Michaela Scherr; Rita Gerardy-Schahn
Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells.
European journal of cell biology 2013;92(1):21-9.
2012: Saskia Wolf; Svenja Warnecke; Jörg Ehrit; Friedrich Freiberger; Rita Gerardy-Schahn; Chris Meier
Chemical synthesis and enzymatic testing of CMP-sialic acid derivatives.
Chembiochem : a European journal of chemical biology 2012;13(17):2605-15.
2012: David Schwarzer; Katharina Stummeyer; Andrea Bethe; valorie bowman; Christopher Browning; Falk F R Buettner; Petr G Leiman; Martina Mühlenhoff; Sergey Nazarov; Astrid Oberbeck; Wolfgang Rabsch; Rita Gerardy-Schahn
A multivalent adsorption apparatus explains the broad host range of phage phi92: a comprehensive genomic and structural analysis.
Journal of virology 2012;86(19):10384-98.
2012: Sebastian P Galuska; Rita Gerardy-Schahn; Hildegard Geyer; Peter Kaese; Siegfried Kühnhardt; Werner Mink; Martina Mühlenhoff; Benedikt Schäfer; Friedrich Freiberger; Rudolf Geyer
Glycomic strategy for efficient linkage analysis of di-, oligo- and polysialic acids.
Journal of proteomics 2012;75(17):5266-78.
2012: Alexandre Benani; Xavier Brenachot; André Colom; Thibaut Duparc; Xavier Fioramonti; Jean Gascuel; Rita Gerardy-Schahn; Alexandra Gouazé; Christophe Guissard; Cécile Hryhorczuk; Claude Knauf; Alice Krezymon; Aleth Lemoine; Anne Lorsignol; Emmanuelle Nédélec; Caroline Rigault; Philippe Valet; Luc Pénicaud
Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(35):11970-9.
2012: Timothy G Keys; Jonas Krueger; Falk F R Buettner; Katinka Eggers; Jörg Ehrit; Friedrich Freiberger; Rita Gerardy-Schahn
A universal fluorescent acceptor for high-performance liquid chromatography analysis of pro- and eukaryotic polysialyltransferases.
Analytical biochemistry 2012;427(2):107-15.
2012: Birgit Weinhold; Kirstin Worthmann; Brigitte Philippens; Wiebke Schaper; Mario Schiffer; Melanie Sellmeier; Ulrike Bernard; Linda Blume; Sebastian P Galuska; Rita Gerardy-Schahn; Hildegard Geyer; Rudolf Geyer; Stephanie Groos; Elina Kats; Anja K Münster-Kühnel
Deficits in sialylation impair podocyte maturation.
Journal of the American Society of Nephrology : JASN 2012;23(8):1319-28.
2012: Timothy G Keys; Monika Berger; Rita Gerardy-Schahn
A high-throughput screen for polysialyltransferase activity.
Analytical biochemistry 2012;427(1):60-8.
2012: Gaga Kochlamazashvili; Benedikt Salmen; Melitta Schachner; Oleg Senkov; Olena Bukalo; Andreas K Engel; Rita Gerardy-Schahn; Alexander Dityatev
Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(7):2263-75.
2012: Maya K Sethi; Hideyuki Takeuchi; Angel Ashikov; Falk F R Buettner; Rita Gerardy-Schahn; Robert S Haltiwanger; Vadim B Krylov; Nikolay E Nifantiev; Hans Bakker
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch.
The Journal of biological chemistry 2012;287(4):2739-48.
2011: Benjamin Kraft; Meike Scharenberg; Rita Gerardy-Schahn; Anita Johswich; Gwenda Kauczor; Hans Bakker
"Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein.
Cellular and molecular life sciences : CMLS 2011;68(24):4091-100.
2011: Hao Hu; Tim B Hucho; Kimia Kahrizi; Ideh Bahman; Wei Chen; Katinka Eggers; Masoud Garshasbi; Rita Gerardy-Schahn; Masoumeh Hosseini; Mohammad Mahdi Motazacker; Martina Mühlenhoff; Hossein Najmabadi; H Hilger Ropers; Andreas Tzschach; Klaus Wrogemann; Andreas W Kuss
ST3GAL3 mutations impair the development of higher cognitive functions.
American journal of human genetics 2011;89(3):407-14.
2011: Ran Chen; Rita Gerardy-Schahn; Bernd Hitzmann; Jinu John; Cornelia Kasper; Bastian Rode; Thomas Scheper
Comparison of polysialic acid production in Escherichia coli K1 during batch cultivation and fed-batch cultivation applying two different control strategies.
Journal of biotechnology 2011;154(4):222-9.
2011: Angela Rey-Gallardo; Cristina Delgado-Martín; Rita Gerardy-Schahn; José L Rodríguez-Fernández; Miguel A Vega
Polysialic acid is required for neuropilin-2a/b-mediated control of CCL21-driven chemotaxis of mature dendritic cells and for their migration in vivo.
Glycobiology 2011;21(5):655-62.
2011: Jörg Ahrens; Reinhard Dengler; Ania Eberhardt; Nilufar Foadi; Rita Gerardy-Schahn; Gertrud Haeseler; Andreas Leffler; Martina Mühlenhoff; Martin Leuwer
Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells.
Pharmacology 2011;87(5-6):311-7.
2010: Kirsten Haastert-Talini; Janett Schaper-Rinkel; Ruth Schmitte; Rode Bastian; Martina Mühlenhoff; David Schwarzer; Gerald Draeger; Yi Su; Thomas Scheper; Rita Gerardy-Schahn; Claudia Grothe
In vivo evaluation of polysialic acid as part of tissue-engineered nerve transplants.
Tissue engineering. Part A 2010;16(10):3085-98.
2010: Angela Rey-Gallardo; Cristina Escribano; Cristina Delgado-Martín; José L Rodriguez-Fernández; Rita Gerardy-Schahn; Urs Rutishauser; Angel L Corbi; Miguel A Vega
Polysialylated neuropilin-2 enhances human dendritic cell migration through the basic C-terminal region of CCL21.
Glycobiology 2010;20(9):1139-46.
2010: Anton Pekcec; Birgit Weinhold; Rita Gerardy-Schahn; Heidrun Potschka
Polysialic acid affects pathophysiological consequences of status epilepticus.
Neuroreport 2010;21(8):549-53.
2010: Sebastian P Galuska; Hildegard Geyer; Birgit Weinhold; Maria Kontou; René C Röhrich; Ulrike Bernard; Rita Gerardy-Schahn; Werner Reutter; Anja Münster-Kühnel; Rudolf Geyer
Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling.
Analytical chemistry 2010;82(11):4591-8.
2010: Eike Christian Schulz; David Schwarzer; Martin Frank; Katharina Stummeyer; Martina Mühlenhoff; Achim Dickmanns; Rita Gerardy-Schahn; Ralf Ficner
Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF.
Journal of molecular biology 2010;397(1):341-51.
2010: Gaga Kochlamazashvili; Oleg Senkov; Sergei Grebenyuk; Catrina Robinson; Mei-Fang Xiao; Katharina Stummeyer; Rita Gerardy-Schahn; Andreas K Engel; Larry Feig; Alexey Semyanov; Vishnu Suppiramaniam; Melitta Schachner; Alexander Dityatev
Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(11):4171-83.
2010: Eike C Schulz; Piotr Neumann; Rita Gerardy-Schahn; George M Sheldrick; Ralf Ficner
Structure analysis of endosialidase NF at 0.98 A resolution.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 2):176-80.
2010: Eike C Schulz; Achim Dickmanns; Henning Urlaub; Andreas Schmitt; Martina Mühlenhoff; Katharina Stummeyer; David Schwarzer; Rita Gerardy-Schahn; Ralf Ficner
Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding.
Nature structural & molecular biology 2010;17(2):210-5.
2010: Raphael Böhm; Friedrich Freiberger; Katharina Stummeyer; Rita Gerardy-Schahn; Mark von Itzstein; Thomas Haselhorst
Neisseria meningitidis serogroup B polysialyltransferase: insights into substrate binding.
Chembiochem : a European journal of chemical biology 2010;11(2):170-4.
2010: Maya K Sethi; Falk F R Buettner; Vadim B Krylov; Hideyuki Takeuchi; Nikolay E Nifantiev; Robert S Haltiwanger; Rita Gerardy-Schahn; Hans Bakker
Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats.
The Journal of biological chemistry 2010;285(3):1582-6.
2010: Chawaree Chaipan; Imke Steffen; Theodros Solomon Tsegaye; Stephanie Bertram; Ilona Glowacka; Yukinari Kato; Jan Schmökel; Jan Münch; Graham Simmons; Rita Gerardy-Schahn; Stefan Pöhlmann
Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2.
Retrovirology 2010;7():47.
2010: Herbert Hildebrandt; Martina Mühlenhoff; Rita Gerardy-Schahn
Polysialylation of NCAM.
Advances in experimental medicine and biology 2010;663():95-109.
2009: Melanie Oschlies; Achim Dickmanns; Thomas Haselhorst; Wiebke Schaper; Katharina Stummeyer; Joe Tiralongo; Birgit Weinhold; Rita Gerardy-Schahn; Mark von Itzstein; Ralf Ficner; Anja K Münster-Kühnel
A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme.
Journal of molecular biology 2009;393(1):83-97.
2009: Herbert Hildebrandt; Martina Mühlenhoff; Imke Oltmann-Norden; Iris Röckle; Hannelore Burkhardt; Birgit Weinhold; Rita Gerardy-Schahn
Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity.
Brain : a journal of neurology 2009;132(Pt 10):2831-8.
2009: Penelope M Drake; Christina M Stock; Jay K Nathan; Phung Gip; Kevin P K Golden; Birgit Weinhold; Rita Gerardy-Schahn; Carolyn R Bertozzi
Polysialic acid governs T-cell development by regulating progenitor access to the thymus.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):11995-2000.
2009: Martina Mühlenhoff; Imke Oltmann-Norden; Birgit Weinhold; Herbert Hildebrandt; Rita Gerardy-Schahn
Brain development needs sugar: the role of polysialic acid in controlling NCAM functions.
Biological chemistry 2009;390(7):567-74.
2009: David Schwarzer; Katharina Stummeyer; Thomas Haselhorst; Friedrich Freiberger; Bastian Rode; Melanie Grove; Thomas Scheper; Mark von Itzstein; Martina Mühlenhoff; Rita Gerardy-Schahn
Proteolytic release of the intramolecular chaperone domain confers processivity to endosialidase F.
The Journal of biological chemistry 2009;284(14):9465-74.
2009: Julia Jungnickel; Christian Brämer; Paul Bronzlik; Esther Lipokatic-Takacs; Birgit Weinhold; Rita Gerardy-Schahn; Claudia Grothe
Level and localization of polysialic acid is critical for early peripheral nerve regeneration.
Molecular and cellular neurosciences 2009;40(3):374-81.
2009: Hans Bakker; Takuji Oka; Angel Ashikov; Ajit Yadav; Monika Berger; Nadia A Rana; Xiaomei Bai; Yoshifumi Jigami; Robert S Haltiwanger; Jeffrey D Esko; Rita Gerardy-Schahn
Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase.
The Journal of biological chemistry 2009;284(4):2576-83.
2009: Anita Johswich; Benjamin Kraft; Manfred Wuhrer; Monika Berger; André M Deelder; Cornelis H Hokke; Rita Gerardy-Schahn; Hans Bakker
Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot.
The Journal of cell biology 2009;184(1):173-83.
2009: Kaan Boztug; Giridharan Appaswamy; Angel Ashikov; Alejandro A Schäffer; Ulrich Salzer; Jana Diestelhorst; Manuela Germeshausen; Gudrun Brandes; Jacqueline Lee-Gossler; Fatih Noyan; Anna-Katherina Gatzke; Milen Minkov; Johann Greil; Christian Kratz; Theoni Petropoulou; Isabelle Pellier; Christine Bellanné-Chantelot; Nima Rezaei; Kirsten Mönkemöller; Noha Irani-Hakimeh; Hans Bakker; Rita Gerardy-Schahn; Cornelia Zeidler; Bodo Grimbacher; Karl Welte; Christoph Klein
A syndrome with congenital neutropenia and mutations in G6PC3.
The New England journal of medicine 2009;360(1):32-43.
2008: Penelope M Drake; Jay K Nathan; Christina M Stock; Pamela V Chang; Marcus O Muench; Daisuke Nakata; J Rachel Reader; Phung Gip; Kevin P K Golden; Birgit Weinhold; Rita Gerardy-Schahn; Frederic A Troy; Carolyn R Bertozzi
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6850-8.
2008: Silke Berski; Jeroen van Bergeijk; David Schwarzer; Yvonne Stark; Cornelia Kasper; Thomas Scheper; Claudia Grothe; Rita Gerardy-Schahn; Andreas Kirschning; Gerald Dräger
Synthesis and biological evaluation of a polysialic acid-based hydrogel as enzymatically degradable scaffold material for tissue engineering.
Biomacromolecules 2008;9(9):2353-9.
2008: Sina Hartlieb; Almut Günzel; Rita Gerardy-Schahn; Anja K Münster-Kühnel; Andreas Kirschning; Gerald Dräger
Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid.
Carbohydrate research 2008;343(12):2075-82.
2008: Hans Bakker; Francoise Routier; Angel Ashikov; Detlef Neumann; Dirk Bosch; Rita Gerardy-Schahn
A CMP-sialic acid transporter cloned from Arabidopsis thaliana.
Carbohydrate research 2008;343(12):2148-52.
2008: Iris Röckle; Ralph Seidenfaden; Birgit Weinhold; Martina Mühlenhoff; Rita Gerardy-Schahn; Herbert Hildebrandt
Polysialic acid controls NCAM-induced differentiation of neuronal precursors into calretinin-positive olfactory bulb interneurons.
Developmental neurobiology 2008;68(9):1170-84.
2008: Bastian Rode; Christian Endres; Chen Ran; Frank Stahl; Sascha Beutel; Cornelia Kasper; Sebastian Galuska; Rudolf Geyer; Martina Mühlenhoff; Rita Gerardy-Schahn; Thomas Scheper
Large-scale production and homogenous purification of long chain polysialic acids from E. coli K1.
Journal of biotechnology 2008;135(2):202-9.
2008: Heidrun Potschka; Anton Pekcec; B Weinhold; Rita Gerardy-Schahn
Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX.
Neuroscience 2008;152(4):1093-8.
2008: Yohannes Haile; Silke Berski; Gerald Dräger; André Dos Santos Nobre; Katharina Stummeyer; Rita Gerardy-Schahn; Claudia Grothe
The effect of modified polysialic acid based hydrogels on the adhesion and viability of primary neurons and glial cells.
Biomaterials 2008;29(12):1880-91.
2008: Anton Pekcec; Christina Fuest; Martina Mühlenhoff; Rita Gerardy-Schahn; Heidrun Potschka
Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development.
Journal of neurochemistry 2008;105(2):389-400.
2008: Anita Stolz; Nicola Haines; Andreas Pich; Kenneth D Irvine; Cornelis H Hokke; André M Deelder; Rita Gerardy-Schahn; Manfred Wuhrer; Hans Bakker
Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis.
Glycoconjugate journal 2008;25(2):167-75.
2008: Imke Oltmann-Norden; Sebastian P Galuska; Herbert Hildebrandt; Rudolf Geyer; Rita Gerardy-Schahn; Hildegard Geyer; Martina Mühlenhoff
Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development.
The Journal of biological chemistry 2008;283(3):1463-71.
2008: Sebastian P Galuska; Rudolf Geyer; Rita Gerardy-Schahn; Martina Mühlenhoff; Hildegard Geyer
Enzyme-dependent variations in the polysialylation of the neural cell adhesion molecule (NCAM) in vivo.
The Journal of biological chemistry 2008;283(1):17-28.
2007: Herbert Hildebrandt; Martina Mühlenhoff; Birgit Weinhold; Rita Gerardy-Schahn
Dissecting polysialic acid and NCAM functions in brain development.
Journal of neurochemistry 2007;103 Suppl 1():56-64.
2007: Andrea Maggioni; Mark von Itzstein; Rita Gerardy-Schahn; Joe Tiralongo
Targeting the expression of functional murine CMP-sialic acid transporter to the E. coli inner membrane.
Biochemical and biophysical research communications 2007;362(3):779-84.
2007: Sabrina Curreli; Zita Arany; Rita Gerardy-Schahn; Dean L Mann; Nicholas M Stamatos
Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions.
The Journal of biological chemistry 2007;282(42):30346-56.
2007: Friedrich Freiberger; Heike Claus; Almut Günzel; Imke Oltmann-Norden; Justine Vionnet; Martina Mühlenhoff; Ulrich Vogel; Willie F Vann; Rita Gerardy-Schahn; Katharina Stummeyer
Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases.
Molecular microbiology 2007;65(5):1258-75.
2007: Joe Tiralongo; Akiko Fujita; Chihiro Sato; Ken Kitajima; Friederike Lehmann; Melanie Oschlies; Rita Gerardy-Schahn; Anja K Münster-Kühnel
The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme.
Glycobiology 2007;17(9):945-54.
2007: Petr Leiman; Anthony J Battisti; valorie bowman; Katharina Stummeyer; Martina Mühlenhoff; Rita Gerardy-Schahn; Dean Scholl; Ian J Molineux
The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities.
Journal of molecular biology 2007;371(3):836-49.
2007: Thomas Haselhorst; Anja K Münster-Kühnel; Melanie Oschlies; Joe Tiralongo; Rita Gerardy-Schahn; Mark von Itzstein
Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy.
Biochemical and biophysical research communications 2007;359(4):866-70.
2007: Anton Pekcec; Martina Mühlenhoff; Rita Gerardy-Schahn; Heidrun Potschka
Impact of the PSA-NCAM system on pathophysiology in a chronic rodent model of temporal lobe epilepsy.
Neurobiology of disease 2007;27(1):54-66.
2007: Monika Marx; Eric Rivera-Milla; Katharina Stummeyer; Rita Gerardy-Schahn; Martin Bastmeyer
Divergent evolution of the vertebrate polysialyltransferase Stx and Pst genes revealed by fish-to-mammal comparison.
Developmental biology 2007;306(2):560-71.
2007: Thomas Steiner; Anne-Christin Lamerz; Petra Hess; Constanze Breithaupt; Stephan Krapp; Gleb P Bourenkov; Robert Huber; Rita Gerardy-Schahn; Uwe Jacob
Open and closed structures of the UDP-glucose pyrophosphorylase from Leishmania major.
The Journal of biological chemistry 2007;282(17):13003-10.
2007: Barbara Kleczka; Anne-Christin Lamerz; Ger van Zandbergen; Alexander Wenzel; Rita Gerardy-Schahn; Martin Wiese; Francoise Routier
Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence.
The Journal of biological chemistry 2007;282(14):10498-505.
2007: David Schwarzer; Katharina Stummeyer; Rita Gerardy-Schahn; Martina Mühlenhoff
Characterization of a novel intramolecular chaperone domain conserved in endosialidases and other bacteriophage tail spike and fiber proteins.
The Journal of biological chemistry 2007;282(5):2821-31.
2007: Y Haile; Kirsten Haastert; Konstantin Cesnulevicius; Katharina Stummeyer; Marco Timmer; S Berski; G Dräger; Rita Gerardy-Schahn; Claudia Grothe
Culturing of glial and neuronal cells on polysialic acid.
Biomaterials 2007;28(6):1163-73.
2006: Thomas Haselhorst; Katharina Stummeyer; Martina Mühlenhoff; Wiebke Schaper; Rita Gerardy-Schahn; Mark von Itzstein
Endosialidase NF appears to bind polySia DP5 in a helical conformation.
Chembiochem : a European journal of chemical biology 2006;7(12):1875-7.
2006: Sebastian P Galuska; Imke Oltmann-Norden; Hildegard Geyer; Birgit Weinhold; Klaus Kuchelmeister; Herbert Hildebrandt; Rita Gerardy-Schahn; Rudolf Geyer; Martina Mühlenhoff
Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV.
The Journal of biological chemistry 2006;281(42):31605-15.
2006: Oleg Senkov; Mu Sun; Birgit Weinhold; Rita Gerardy-Schahn; Melitta Schachner; Alexander Dityatev
Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(42):10888-109898.
2006: Thomas Haselhorst; Melanie Oschlies; Tareq Abu-Izneid; Milton J Kiefel; Joe Tiralongo; Anja K Münster-Kühnel; Rita Gerardy-Schahn; Mark von Itzstein
A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase.
Glycoconjugate journal 2006;23(5-6):371-5.
2006: Anne-Christin Lamerz; Thomas Haselhorst; Anne K Bergfeld; Mark von Itzstein; Rita Gerardy-Schahn
Molecular cloning of the Leishmania major UDP-glucose pyrophosphorylase, functional characterization, and ligand binding analyses using NMR spectroscopy.
The Journal of biological chemistry 2006;281(24):16314-22.
2006: Katharina Stummeyer; David Schwarzer; Heike Claus; Ulrich Vogel; Rita Gerardy-Schahn; Martina Mühlenhoff
Evolution of bacteriophages infecting encapsulated bacteria: lessons from Escherichia coli K1-specific phages.
Molecular microbiology 2006;60(5):1123-35.
2006: Luminita Stoenica; Oleg Senkov; Rita Gerardy-Schahn; Birgit Weinhold; Melitta Schachner; Alexander Dityatev
In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid.
The European journal of neuroscience 2006;23(9):2255-64.
2006: Joe Tiralongo; Angel Ashikov; Francoise Routier; Matthias Eckhardt; Hans Bakker; Rita Gerardy-Schahn; Mark von Itzstein
Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier.
Glycobiology 2006;16(1):73-81.
2005: Birgit Weinhold; Ralph Seidenfaden; Iris Röckle; Martina Mühlenhoff; Frank Schertzinger; Sidonie Conzelmann; Jamey D Marth; Rita Gerardy-Schahn; Herbert Hildebrandt
Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.
The Journal of biological chemistry 2005;280(52):42971-7.
2005: Roland Kabuss; Angel Ashikov; Stefan Oelmann; Rita Gerardy-Schahn; Hans Bakker
Endoplasmic reticulum retention of the large splice variant of the UDP-galactose transporter is caused by a dilysine motif.
Glycobiology 2005;15(10):905-11.
2005: Kaya Bork; Werner Reutter; Rita Gerardy-Schahn; Rüdiger Horstkorte
The intracellular concentration of sialic acid regulates the polysialylation of the neural cell adhesion molecule.
FEBS letters 2005;579(22):5079-83.
2005: Angel Ashikov; Francoise Routier; Jutta Fuhlrott; Yvonne Helmus; Martin Wild; Rita Gerardy-Schahn; Hans Bakker
The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.
The Journal of biological chemistry 2005;280(29):27230-5.
2005: Hans Bakker; Barbara Kleczka; Rita Gerardy-Schahn; Francoise Routier
Identification and partial characterization of two eukaryotic UDP-galactopyranose mutases.
Biological chemistry 2005;386(7):657-61.
2005: Thomas Haselhorst; Anja K Münster-Kühnel; Anita Stolz; Melanie Oschlies; Joe Tiralongo; Ken Kitajima; Rita Gerardy-Schahn; Mark von Itzstein
Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy.
Biochemical and biophysical research communications 2005;327(2):565-70.
2005: Akiko Fujita; Chihiro Sato; Anja K Münster-Kühnel; Rita Gerardy-Schahn; Ken Kitajima
Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system.
Analytical biochemistry 2005;337(1):12-21.
2005: Hans Bakker; Francoise Routier; Stefan Oelmann; Wilco Jordi; Arjen Lommen; Rita Gerardy-Schahn; Dirk Bosch
Molecular cloning of two Arabidopsis UDP-galactose transporters by complementation of a deficient Chinese hamster ovary cell line.
Glycobiology 2005;15(2):193-201.
2005: Katharina Stummeyer; Achim Dickmanns; Martina Mühlenhoff; Rita Gerardy-Schahn; Ralf Ficner
Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F.
Nature structural & molecular biology 2005;12(1):90-6.
2004: Anja K Münster-Kühnel; Joe Tiralongo; Stephan Krapp; Birgit Weinhold; Valentina Ritz-Sedlacek; Uwe Jacob; Rita Gerardy-Schahn
Structure and function of vertebrate CMP-sialic acid synthetases.
Glycobiology 2004;14(10):43R-51R.
2004: Rüdiger Horstkorte; Martina Mühlenhoff; Werner Reutter; Sabine Nöhring; Martin Zimmermann-Kordmann; Rita Gerardy-Schahn
Selective inhibition of polysialyltransferase ST8SiaII by unnatural sialic acids.
Experimental cell research 2004;298(1):268-74.
2004: Edward L Kean; Anja K Münster-Kühnel; Rita Gerardy-Schahn
CMP-sialic acid synthetase of the nucleus.
Biochimica et biophysica acta 2004;1673(1-2):56-65.
2003: Stephan Krapp; Anja K Münster-Kühnel; Jens Thomas Kaiser; Robert Huber; Joe Tiralongo; Rita Gerardy-Schahn; Uwe Jacob
The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase.
Journal of molecular biology 2003;334(4):625-37.
2003: Ralph Seidenfaden; Andrea Krauter; Frank Schertzinger; Rita Gerardy-Schahn; Herbert Hildebrandt
Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions.
Molecular and cellular biology 2003;23(16):5908-18.
2003: Martina Mühlenhoff; Katharina Stummeyer; Melanie Grove; Markus Sauerborn; Rita Gerardy-Schahn
Proteolytic processing and oligomerization of bacteriophage-derived endosialidases.
The Journal of biological chemistry 2003;278(15):12634-44.
2003: Manfred Wuhrer; Hildegard Geyer; Maren von der Ohe; Rita Gerardy-Schahn; Melitta Schachner; Rudolf Geyer
Localization of defined carbohydrate epitopes in bovine polysialylated NCAM.
Biochimie 2003;85(1-2):207-18.
2002: Anja-K Munster; Birgit Weinhold; Birgit Gotza; Martina Muhlenhoff; Matthias Frosch; Rita Gerardy-Schahn
Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity.
The Journal of biological chemistry 2002;277(22):19688-96.
2002: Maren von Der Ohe; Susan F Wheeler; Manfred Wuhrer; David Harvey; Steffen Liedtke; Martina Mühlenhoff; Rita Gerardy-Schahn; Hildegard Geyer; Raymond A Dwek; Rudolf Geyer; David R Wing; Melitta Schachner
Localization and characterization of polysialic acid-containing N-linked glycans from bovine NCAM.
Glycobiology 2002;12(1):47-63.
2001: T Schuster; M Krug; M Stalder; N Hackel; Rita Gerardy-Schahn; Melitta Schachner
Immunoelectron microscopic localization of the neural recognition molecules L1, NCAM, and its isoform NCAM180, the NCAM-associated polysialic acid, beta1 integrin and the extracellular matrix molecule tenascin-R in synapses of the adult rat hippocampus.
Journal of neurobiology 2001;49(2):142-58.
2001: Martina Mühlenhoff; A Manegold; M Windfuhr; Birgit Gotza; Rita Gerardy-Schahn
The impact of N-glycosylation on the functions of polysialyltransferases.
The Journal of biological chemistry 2001;276(36):34066-73.
2001: Rita Gerardy-Schahn; Stefan Oelmann; Hans Bakker
Nucleotide sugar transporters: biological and functional aspects.
Biochimie 2001;83(8):775-82.
2001: Daisuke Nakata; A K Münster; Rita Gerardy-Schahn; N Aoki; Tsukasa Matsuda; Ken Kitajima
Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates.
Glycobiology 2001;11(8):685-92.
2001: Stefan Oelmann; Pamela Stanley; Rita Gerardy-Schahn
Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters.
The Journal of biological chemistry 2001;276(28):26291-300.
2001: Steffen Liedtke; Hildegard Geyer; Manfred Wuhrer; Rudolf Geyer; G Frank; Rita Gerardy-Schahn; Ulrich Zähringer; Melitta Schachner
Characterization of N-glycans from mouse brain neural cell adhesion molecule.
Glycobiology 2001;11(5):373-84.
2001: Kerstin Lühn; Martin K Wild; M Eckhardt; Rita Gerardy-Schahn; Dietmar Vestweber
The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter.
Nature genetics 2001;28(1):69-72.
2000: M Windfuhr; A Manegold; M Muhlenhoff; M Eckhardt; Rita Gerardy-Schahn
Molecular defects that cause loss of polysialic acid in the complementation group 2A10.
The Journal of biological chemistry 2000;275(42):32861-70.
2000: Ralph Seidenfaden; Rita Gerardy-Schahn; Herbert Hildebrandt
Control of NCAM polysialylation by the differential expression of polysialyltransferases ST8SiaII and ST8SiaIV.
European journal of cell biology 2000;79(10):680-8.
2000: Joe Tiralongo; S Abo; B Danylec; Rita Gerardy-Schahn; Mark von Itzstein
A high-throughput assay for rat liver golgi and Saccharomyces cerevisiae-expressed murine CMP-N-acetylneuraminic acid transport proteins.
Analytical biochemistry 2000;285(1):21-32.
2000: M Eckhardt; Olena Bukalo; Geneviève Chazal; L Wang; Christo Goridis; Melitta Schachner; Rita Gerardy-Schahn; Harold Cremer; Alexander Dityatev
Mice deficient in the polysialyltransferase ST8SiaIV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(14):5234-44.
1999: M Eckhardt; Birgit Gotza; Rita Gerardy-Schahn
Membrane topology of the mammalian CMP-sialic acid transporter.
The Journal of biological chemistry 1999;274(13):8779-87.
1999: Rüdiger Horstkorte; N Lessner; Rita Gerardy-Schahn; Lothar Lucka; Kerstin Danker; Werner Reutter
Expression of the polysialyltransferase ST8SiaIV: polysialylation interferes with adhesion of PC12 cells in vitro.
Experimental cell research 1999;246(1):122-8.
1998: M Eckhardt; Rita Gerardy-Schahn
Genomic organization of the murine polysialyltransferase gene ST8SiaIV (PST-1).
Glycobiology 1998;8(12):1165-72.
1998: Sylvia Glüer; MA Wunder; C Schelp; E Radtke; Rita Gerardy-Schahn
Polysialylated neural cell adhesion molecule serum levels in normal children.
Pediatric research 1998;44(6):915-9.
1998: Herbert Hildebrandt; C Becker; M Mürau; Rita Gerardy-Schahn; Hinrich Rahmann
Heterogeneous expression of the polysialyltransferases ST8Sia II and ST8Sia IV during postnatal rat brain development.
Journal of neurochemistry 1998;71(6):2339-48.
1998: Martina Mühlenhoff; M Eckhardt; Rita Gerardy-Schahn
Polysialic acid: three-dimensional structure, biosynthesis and function.
Current opinion in structural biology 1998;8(5):558-64.
1998: Sylvia Glüer; C Schelp; Rita Gerardy-Schahn; Dietrich von Schweinitz
Polysialylated neural cell adhesion molecule as a marker for differential diagnosis in pediatric tumors.
Journal of pediatric surgery 1998;33(10):1516-20.
1998: M Eckhardt; Birgit Gotza; Rita Gerardy-Schahn
Mutants of the CMP-sialic acid transporter causing the Lec2 phenotype.
The Journal of biological chemistry 1998;273(32):20189-95.
1998: A K Münster; M Eckhardt; Barry Potvin; Martina Mühlenhoff; Pamela Stanley; Rita Gerardy-Schahn
Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9140-5.
1998: Sylvia Glüer; C Schelp; N Madry; Dietrich von Schweinitz; M Eckhardt; Rita Gerardy-Schahn
Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.
British journal of cancer 1998;78(1):106-10.
1998: Herbert Hildebrandt; C Becker; Sylvia Glüer; Harald Rösner; Rita Gerardy-Schahn; Hinrich Rahmann
Polysialic acid on the neural cell adhesion molecule correlates with expression of polysialyltransferases and promotes neuroblastoma cell growth.
Cancer research 1998;58(4):779-84.
1998: Sylvia Glüer; C Schelp; Dietrich von Schweinitz; Rita Gerardy-Schahn
Polysialylated neural cell adhesion molecule in childhood rhabdomyosarcoma.
Pediatric research 1998;43(1):145-7.
1997: Heike Claus; Ulrich Vogel; Martina Mühlenhoff; Rita Gerardy-Schahn; Matthias Frosch
Molecular divergence of the sia locus in different serogroups of Neisseria meningitidis expressing polysialic acid capsules.
Molecular & general genetics : MGG 1997;257(1):28-34.
1997: M Eckhardt; Rita Gerardy-Schahn
Molecular cloning of the hamster CMP-sialic acid transporter.
European journal of biochemistry / FEBS 1997;248(1):187-92.
1997: Patricia M Berninsone; M Eckhardt; Rita Gerardy-Schahn; Carlos B Hirschberg
Functional expression of the murine Golgi CMP-sialic acid transporter in saccharomyces cerevisiae.
The Journal of biological chemistry 1997;272(19):12616-9.
1996: Martina Mühlenhoff; M Eckhardt; A Bethe; Matthias Frosch; Rita Gerardy-Schahn
Autocatalytic polysialylation of polysialyltransferase-1.
The EMBO journal 1996;15(24):6943-50.
1996: Martina Mühlenhoff; M Eckhardt; A Bethe; Matthias Frosch; Rita Gerardy-Schahn
Polysialylation of NCAM by a single enzyme.
Current biology : CB 1996;6(9):1188-91.
1996: M Eckhardt; Martina Mühlenhoff; A Bethe; Rita Gerardy-Schahn
Expression cloning of the Golgi CMP-sialic acid transporter.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7572-6.
1996: S Hammerschmidt; A Müller; H Sillmann; Martina Mühlenhoff; R Borrow; A Fox; J van Putten; W D Zollinger; Rita Gerardy-Schahn; Matthias Frosch
Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal disease.
Molecular microbiology 1996;20(6):1211-20.
1996: S Hammerschmidt; R Hilse; J P van Putten; Rita Gerardy-Schahn; Alexandra Schubert-Unkmeir; Matthias Frosch
Modulation of cell surface sialic acid expression in Neisseria meningitidis via a transposable genetic element.
The EMBO journal 1996;15(1):192-8.
1995: Rita Gerardy-Schahn; A Bethe; T Brennecke; Martina Mühlenhoff; M Eckhardt; Stefan Ziesing; F Lottspeich; Matthias Frosch
Molecular cloning and functional expression of bacteriophage PK1E-encoded endoneuraminidase Endo NE.
Molecular microbiology 1995;16(3):441-50.
1995: M Eckhardt; Martina Mühlenhoff; A Bethe; J Koopman; Matthias Frosch; Rita Gerardy-Schahn
Molecular characterization of eukaryotic polysialyltransferase-1.
Nature 1995;373(6516):715-8.
1994: U Edwards; A Müller; S Hammerschmidt; Rita Gerardy-Schahn; Matthias Frosch
Molecular analysis of the biosynthesis pathway of the alpha-2,8 polysialic acid capsule by Neisseria meningitidis serogroup B.
Molecular microbiology 1994;14(1):141-9.
1994: K Takamatsu; B Auerbach; Rita Gerardy-Schahn; M Eckhardt; G Jaques; N Madry
Characterization of tumor-associated neural cell adhesion molecule in human serum.
Cancer research 1994;54(10):2598-603.
1994: K Takamatsu; B Auerbach; Rita Gerardy-Schahn; G Jaques; D Krause; N Madry
Evaluation of the binding properties of monoclonal antibodies submitted to Third International IASLC Workshop on Lung Tumor and Differentiation Antigens to Neural Cell Adhesion Molecule.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1994;8():30-3.
1994: Rita Gerardy-Schahn; M Eckhardt
Hot spots of antigenicity in the neural cell adhesion molecule NCAM.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1994;8():38-42.
1994: Rita Gerardy-Schahn; M Eckhardt; J Ledermann; J T Kemshead
Topography of NCAM antigenic epitopes recognized by SCLC-cluster-1 antibodies. A consensus view.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1994;8():27-9.
1992: M Federwisch; M Casaretto; Rita Gerardy-Schahn; D Bitter-Suermann; Axel Wollmer
Enhanced biopotency of synthetic C3a analogues by membrane binding. A fluorescence anisotropy decay study.
Biophysical chemistry 1992;44(3):151-61.
1991: Rita Gerardy-Schahn; H W Mittrücker; U Schultze; Bernhard Fleischer
Selective loss of pertussis toxin-sensitive G-proteins from the plasma membrane after antibody-induced internalization of T-cell surface molecules.
The Journal of biological chemistry 1991;266(11):6942-7.
1991: Bernhard Fleischer; Rita Gerardy-Schahn; B Metzroth; S Carrel; D Gerlach; W Köhler
An evolutionary conserved mechanism of T cell activation by microbial toxins. Evidence for different affinities of T cell receptor-toxin interaction.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(1):11-7.
1989: Rita Gerardy-Schahn; D Ambrosius; D Saunders; M Casaretto; C Mittler; G Karwarth; S Görgen; D Bitter-Suermann
Characterization of C3a receptor-proteins on guinea pig platelets and human polymorphonuclear leukocytes.
European journal of immunology 1989;19(6):1095-102.
1989: D Ambrosius; M Casaretto; Rita Gerardy-Schahn; D Saunders; D Brandenburg; H Zahn
Peptide analogues of the anaphylatoxin C3a; syntheses and properties.
Biological chemistry Hoppe-Seyler 1989;370(3):217-27.
1988: Rita Gerardy-Schahn; D Ambrosius; M Casaretto; Joachim Grötzinger; D Saunders; Axel Wollmer; D Brandenburg; D Bitter-Suermann
Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements.
The Biochemical journal 1988;255(1):209-16.
1983: Ralf Schnabel; M Thomm; Rita Gerardy-Schahn; Wolfram Zillig; K O Stetter; J Huet
Structural homology between different archaebacterial DNA-dependent RNA polymerases analyzed by immunological comparison of their components.
The EMBO journal 1983;2(5):751-5.