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Michael German

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Olov Andersson; Gregory C Ellis; Michael S German; Philipp Gut; Bruce A Adams; Ryan M Anderson; Daniel Yoo; Didier Y R Stainier
Adenosine signaling promotes regeneration of pancreatic β cells in vivo.
Gregory M Ku; Chun Chieh Luo; Michael S German; Zachary Pappalardo; Michael McManus
An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production.
Li-Jun Yao; Jian Wang; Katherine Y Yang; Morris J Birnbaum; Krishna M Boini; Gian Luca Colussi; Michael S German; Atif Kidwai; Florian Lang; James McCormick; David Pearce
Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.

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2012: Olov Andersson; Gregory C Ellis; Michael S German; Philipp Gut; Bruce A Adams; Ryan M Anderson; Daniel Yoo; Didier Y R Stainier
Adenosine signaling promotes regeneration of pancreatic β cells in vivo.
Cell metabolism 2012;15(6):885-94.
2012: Gregory M Ku; Chun Chieh Luo; Michael S German; Zachary Pappalardo; Michael McManus
An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production.
PLoS genetics 2012;8(1):e1002449.
2011: Li-Jun Yao; Jian Wang; Katherine Y Yang; Morris J Birnbaum; Krishna M Boini; Gian Luca Colussi; Michael S German; Atif Kidwai; Florian Lang; James McCormick; David Pearce
Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.
Molecular endocrinology (Baltimore, Md.) 2011;25(12):2106-18.
2011: Dennis Van Hoof; Adam D Mendelsohn; Rina Seerke; Tejal A Desai; Michael S German
Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters.
Stem cell research 2011;6(3):276-85.
2011: Takeshi Miyatsuka; Yasuhiro Kosaka; Hail Kim; Michael S German
Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):185-90.
2010: Anna Kalousova; Anastasia Mavropoulos; Bruce A Adams; Nada Nekrep; Zhongmei Li; Stephan Krauss; Didier Y R Stainier; Michael S German
Dachshund homologues play a conserved role in islet cell development.
Developmental biology 2010;348(2):143-52.
2010: Hail Kim; Yukiko Toyofuku; Francis C Lynn; Eric Chak; Toyoyoshi Uchida; Hiroki Mizukami; Yoshio Fujitani; Ryuzo Kawamori; Takeshi Miyatsuka; Yasuhiro Kosaka; Katherine Yang; Gerard Honig; Marieke van der Hart; Nina Kishimoto; Juehu Wang; Soroku Yagihashi; Laurence H Tecott; Hirotaka Watada; Michael S German
Serotonin regulates pancreatic beta cell mass during pregnancy.
Nature medicine 2010;16(7):804-8.
2010: Yu-cheng Wang; Marlene B Zuraek; Yasuhiro Kosaka; Yasuharu Ota; Michael S German; Evan S Deneris; Emily K Bergsland; David B Donner; Robert S Warren; Eric K Nakakura
The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
Endocrine-related cancer 2010;17(1):283-91.
2010: Stuart B Smith; Hui-Qi Qu; Nadine Taleb; Nina Y Kishimoto; David W Scheel; Yang Lu; Ann-Marie Patch; Rosemary Grabs; Juehu Wang; Francis C Lynn; Takeshi Miyatsuka; John Mitchell; Rina Seerke; Julie Désir; Marc Abramowicz; Nadine Kacet; Jacques Weill; Marie-Eve Renard; Mattia Gentile; Inger Hansen; Ken Dewar; Andrew T Hattersley; Rennian Wang; Maria E Wilson; Jeffrey D Johnson; Constantin Polychronakos; Serge Vanden Eijnden; Michael S German
Rfx6 directs islet formation and insulin production in mice and humans.
Nature 2010;463(7282):775-80.
2010: Gerard Honig; Angela Liou; Miles Berger; Michael S German; Laurence H Tecott
Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.
Journal of biomedical science 2010;17():82.
2009: Dennis Van Hoof; Kevin A D'Amour; Michael S German
Derivation of insulin-producing cells from human embryonic stem cells.
Stem cell research 2009;3(2-3):73-87.
2009: Takeshi Miyatsuka; Zhongmei Li; Michael S German
Chronology of islet differentiation revealed by temporal cell labeling.
Diabetes 2009;58(8):1863-8.
2009: Yu-Cheng Wang; Emerick Gallego-Arteche; Gioia Iezza; Xiaochen Yuan; Mary R Matli; Su-Pin Choo; Marlene B Zuraek; Ravi Gogia; Francis C Lynn; Michael S German; Emily K Bergsland; David B Donner; Robert S Warren; Eric K Nakakura
Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.
Endocrine-related cancer 2009;16(1):267-79.
2008: Michael S German
New beta-cells from old acini.
Nature biotechnology 2008;26(10):1092-3.
2008: Nada Nekrep; Juehu Wang; Takeshi Miyatsuka; Michael S German
Signals from the neural crest regulate beta-cell mass in the pancreas.
Development (Cambridge, England) 2008;135(12):2151-60.
2008: David A Cano; Ingrid C Rulifson; Patrick W Heiser; Lamorna Brown Swigart; Stella Pelengaris; Michael S German; Gerard I Evan; Jeffrey A Bluestone; Matthias Hebrok
Regulated beta-cell regeneration in the adult mouse pancreas.
Diabetes 2008;57(4):958-66.
2008: Rosa Gasa; Caroline Mrejen; Francis C Lynn; Peter Skewes-Cox; Lidia Sanchez; Katherine Y Yang; Chin-Hsing Lin; Ramon Gomis; Michael S German
Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.
Differentiation; research in biological diversity 2008;76(4):381-91.
2008: Francis C Lynn; Lidia Sanchez; Ramon Gomis; Michael S German; Rosa Gasa
Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.
PloS one 2008;3(6):e2430.
2007: Francis C Lynn; Peter Skewes-Cox; Yasuhiro Kosaka; Michael McManus; Brian D Harfe; Michael S German
MicroRNA expression is required for pancreatic islet cell genesis in the mouse.
Diabetes 2007;56(12):2938-45.
2007: Francis C Lynn; S B Smith; Maria E Wilson; K Y Yang; Nada Nekrep; Michael S German
Sox9 coordinates a transcriptional network in pancreatic progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10500-5.
2005: Maria E Wilson; Katherine Y Yang; Anna Kalousova; Janet Lau; Yasuhiro Kosaka; Francis C Lynn; Juehu Wang; Caroline Mrejen; Vasso Episkopou; Hans Clevers; Michael S German
The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.
Diabetes 2005;54(12):3402-9.
2005: Jonathan Schisler; Per Bo Jensen; David G Taylor; Thomas C Becker; Filip K Knop; Shiro Takekawa; Michael S German; Gordon C Weir; Danhong Lu; Raghavendra G Mirmira; Christopher B Newgard
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7297-302.
2005: Hiroshi Kawahira; David W Scheel; Stuart B Smith; Michael S German; Matthias Hebrok
Hedgehog signaling regulates expansion of pancreatic epithelial cells.
Developmental biology 2005;280(1):111-21.
2004: Rosa Gasa; Caroline Mrejen; Nathaniel Leachman; Marc Otten; Michael Barnes; Juehu Wang; Swarup Chakrabarti; Raghavendra G Mirmira; Michael S German
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13245-50.
2004: Shih Khoo; Tara Beers Gibson; Don Arnette; Michael Lawrence; Bridgette January; Kathleen McGlynn; Colleen A Vanderbilt; Steven C Griffen; Michael S German; Melanie H Cobb
MAP kinases and their roles in pancreatic beta-cells.
Cell biochemistry and biophysics 2004;40(3 Suppl):191-200.
2004: Stuart B Smith; Hirotaka Watada; Michael S German
Neurogenin3 activates the islet differentiation program while repressing its own expression.
Molecular endocrinology (Baltimore, Md.) 2004;18(1):142-9.
2003: Stuart B Smith; Rosa Gasa; Hirotaka Watada; Juehu Wang; Steven C Griffen; Michael S German
Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4.
The Journal of biological chemistry 2003;278(40):38254-9.
2003: Shih Khoo; Steven C Griffen; Ying Xia; Richard J Baer; Michael S German; Melanie H Cobb
Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.
The Journal of biological chemistry 2003;278(35):32969-77.
2003: Hirotaka Watada; David W Scheel; Joey Leung; Michael S German
Distinct gene expression programs function in progenitor and mature islet cells.
The Journal of biological chemistry 2003;278(19):17130-40.
2003: Maria E Wilson; David W Scheel; Michael S German
Gene expression cascades in pancreatic development.
Mechanisms of development 2003;120(1):65-80.
2003: Jeffrey Lee; Yuanyuan Wu; Yingchuan Qi; Haipeng Xue; Ying Liu; David W Scheel; Michael S German; Mengsheng Qiu; François Guillemot; Mahendra S Rao; Gérard Gradwohl
Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord.
Developmental biology 2003;253(1):84-98.
2002: Maria E Wilson; Julie A Kalamaras; Michael S German
Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.
Mechanisms of development 2002;115(1-2):171-6.
2001: J C Lee; Stuart B Smith; Hirotaka Watada; J Lin; David W Scheel; Juehu Wang; Raghavendra G Mirmira; Michael S German
Regulation of the pancreatic pro-endocrine gene neurogenin3.
Diabetes 2001;50(5):928-36.
2001: Laura Del Bosque-Plata; J Lin; Yukio Horikawa; P E H Schwarz; Nancy J Cox; Naoko Iwasaki; Makiko Ogata; Yasuhiko Iwamoto; Michael S German; Graeme I Bell
Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.
Diabetes 2001;50(3):694-6.
2001: Steven C Griffen; Juehu Wang; Michael S German
A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat.
Diabetes 2001;50(1):63-8.
2000: M Sander; L Sussel; JR Conners; David W Scheel; Julie A Kalamaras; Filemon Dela Cruz; VM Schwitzgebel; A Hayes-Jordan; Michael S German
Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
Development (Cambridge, England) 2000;127(24):5533-40.
2000: Stuart B Smith; Hirotaka Watada; David W Scheel; Caroline Mrejen; Michael S German
Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter.
The Journal of biological chemistry 2000;275(47):36910-9.
2000: Hirotaka Watada; Raghavendra G Mirmira; J Leung; Michael S German
Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.
The Journal of biological chemistry 2000;275(44):34224-30.
2000: Yukio Horikawa; Y Horikawa; Nancy J Cox; Naoko Iwasaki; Makiko Ogata; Yasuhiko Iwamoto; VM Schwitzgebel; Michael S German; Graeme I Bell
beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.
Diabetes 2000;49(11):1955-7.
2000: M Sander; S Paydar; Johan Ericson; James Briscoe; E Berber; Michael S German; Thomas M Jessell; John L R Rubenstein
Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates.
Genes & development 2000;14(17):2134-9.
2000: Hirotaka Watada; Raghavendra G Mirmira; Julie A Kalamaras; Michael S German
Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9443-8.
2000: VM Schwitzgebel; David W Scheel; JR Conners; Julie A Kalamaras; J E Lee; D J Anderson; L Sussel; J D Johnson; Michael S German
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.
Development (Cambridge, England) 2000;127(16):3533-42.
2000: Raghavendra G Mirmira; Hirotaka Watada; Michael S German
Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.
The Journal of biological chemistry 2000;275(19):14743-51.
2000: K Ohneda; Raghavendra G Mirmira; J Wang; J D Johnson; Michael S German
The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.
Molecular and cellular biology 2000;20(3):900-11.
1999: Stuart B Smith; H C Ee; JR Conners; Michael S German
Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development.
Molecular and cellular biology 1999;19(12):8272-80.
1998: M Sander; Steven C Griffen; J Huang; Michael S German
A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11572-7.
1998: H Furuta; Yukio Horikawa; Naoko Iwasaki; Manami Hara; L Sussel; Michelle M Le Beau; Elizabeth M Davis; Makiko Ogata; Yasuhiko Iwamoto; Michael S German; Graeme I Bell
Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese.
Diabetes 1998;47(8):1356-8.
1998: L Sussel; Julie A Kalamaras; Dennis J Hartigan-O'Connor; Juanito J Meneses; Roger A Pedersen; John L R Rubenstein; Michael S German
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Development (Cambridge, England) 1998;125(12):2213-21.
1997: C A Iannotti; H Inoue; E Bernal; M Aoki; L Liu; H Donis-Keller; Michael S German; M Alan Permutt
Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9.
Genomics 1997;46(3):520-4.
1997: M Sander; A Neubüser; Julie A Kalamaras; H C Ee; Gail R Martin; Michael S German
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
Genes & development 1997;11(13):1662-73.
1997: J D Johnson; W Zhang; A Rudnick; W J Rutter; Michael S German
Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity.
Molecular and cellular biology 1997;17(7):3488-96.
1997: M Sander; Michael S German
The beta cell transcription factors and development of the pancreas.
Journal of molecular medicine (Berlin, Germany) 1997;75(5):327-40.
1997: Jian Wang; L Shen; Habiba Najafi; Janice A Kolberg; F M Matschinsky; MS Urdea; Michael S German
Regulation of insulin preRNA splicing by glucose.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4360-5.
1997: H Inoue; A Rudnick; Michael S German; Rose Veile; H Donis-Keller; Rosalie A Veile
Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene.
Genomics 1997;40(2):367-70.
1996: H Odagiri; J Wang; Michael S German
Function of the human insulin promoter in primary cultured islet cells.
The Journal of biological chemistry 1996;271(4):1909-15.
1996: A Collins; Michael S German; Yuh Nung Jan; Lily Yeh Jan; B Zhao
A strongly inwardly rectifying K+ channel that is sensitive to ATP.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(1):1-9.
1995: M Stoffel; Y Tokuyama; J B Trabb; Michael S German; M L Tsaar; Lily Yeh Jan; Kenneth S Polonsky; Graeme I Bell
Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
Biochemical and biophysical research communications 1995;212(3):894-9.
1995: Meei-Ling Tsaur; Stephan Menzel; F P Lai; Rafael Espinosa; Patrick Concannon; Richard S Spielman; Craig L Hanis; Nancy J Cox; Michelle M Le Beau; Michael S German
Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM.
Diabetes 1995;44(5):592-6.
1995: G C Kennedy; Michael S German; W J Rutter
The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription.
Nature genetics 1995;9(3):293-8.
1994: A Rudnick; T Y Ling; H Odagiri; W J Rutter; Michael S German
Pancreatic beta cells express a diverse set of homeobox genes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12203-7.
1994: Michael S German; J Wang; A A Fernald; Rafael Espinosa; Michelle M Le Beau; G I Bell
Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13.
Genomics 1994;24(2):403-4.
1994: Michael S German; J Wang
The insulin gene contains multiple transcriptional elements that respond to glucose.
Molecular and cellular biology 1994;14(6):4067-75.
1993: Michael S German
Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1781-5.
1992: Michael S German; J Wang; R B Chadwick; W J Rutter
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.
Genes & development 1992;6(11):2165-76.
1992: Michael S German; L G Moss; J Wang; W J Rutter
The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes.
Molecular and cellular biology 1992;12(4):1777-88.
1991: Michael S German; Michael A Blanar; C Nelson; L G Moss; W J Rutter
Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer.
Molecular endocrinology (Baltimore, Md.) 1991;5(2):292-9.
1990: Michael S German; L G Moss; W J Rutter
Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures.
The Journal of biological chemistry 1990;265(36):22063-6.