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Robert Gerszten

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Francesco S Loffredo; Christine M Miller; James R Pancoast; Nikolaos Psychogios; Thomas Serwold; Jennifer L Shadrach; Britta S Singer; Manisha Sinha; Matthew L Steinhauser; Alex Stewart; Amy J Wagers; Pratyusha Yalamanchi; Claudia Dall'osso; Joseph Gannon; Robert E Gerszten; Adam J Hartigan; Steven M Jay; Danika Khong; Mi-Jeong Kim; Richard T Lee
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy.
Anjali K Nath; Lee D Roberts; Gary A Rockwood; Justine H Ryu; Andreas Werdich; Gerry R Boss; Matthew Brenner; Robert E Gerszten; James L Januzzi; Sonia Kim; Yan Liu; Calum A MacRae; Sari B Mahon; Randall T Peterson
Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure.
Shan Jin; Youngnam N Jin; David Kokel; Yan Liu; Calum A MacRae; Lee D Roberts; Kumar S Sarkar; Tjakko J Van Ham; Robert E Gerszten; Randall T Peterson
An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.

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All Publications

2013: Francesco S Loffredo; Christine M Miller; James R Pancoast; Nikolaos Psychogios; Thomas Serwold; Jennifer L Shadrach; Britta S Singer; Manisha Sinha; Matthew L Steinhauser; Alex Stewart; Amy J Wagers; Pratyusha Yalamanchi; Claudia Dall'osso; Joseph Gannon; Robert E Gerszten; Adam J Hartigan; Steven M Jay; Danika Khong; Mi-Jeong Kim; Richard T Lee
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy.
Cell 2013;153(4):828-39.
2013: Anjali K Nath; Lee D Roberts; Gary A Rockwood; Justine H Ryu; Andreas Werdich; Gerry R Boss; Matthew Brenner; Robert E Gerszten; James L Januzzi; Sonia Kim; Yan Liu; Calum A MacRae; Sari B Mahon; Randall T Peterson
Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(5):1928-38.
2013: Shan Jin; Youngnam N Jin; David Kokel; Yan Liu; Calum A MacRae; Lee D Roberts; Kumar S Sarkar; Tjakko J Van Ham; Robert E Gerszten; Randall T Peterson
An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.
Journal of biomolecular screening 2013;18(1):108-15.
2012: Heloisa Sawaya; Igal A Sebag; Timothy C Tan; Susan E Wiegers; Jose Banchs; Joseph R Carver; Victor Cohen; Robert E Gerszten; Elkan F Halpern; James L Januzzi; Irene Kuter; Bonnie Ky; Randolph P Martin; Jonathan Passeri; Michael H Picard; Juan Carlos Plana; Marielle Scherrer-Crosbie
Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab.
Circulation. Cardiovascular imaging 2012;5(5):596-603.
2012: Susan Cheng; Clary B Clish; Amy A Deik; Andre Dejam; Caroline S Fox; Robert E Gerszten; Martin G Larson; Gregory D Lewis; Martin Magnusson; Elizabeth L McCabe; Olle Melander; Christopher J O'Donnell; Melinda J Palma; Eugene P Rhee; Lee D Roberts; Dongxiao Shen; Amanda L Souza; Ramachandran S Vasan; Thomas J Wang
Metabolite profiling identifies pathways associated with metabolic risk in humans.
Circulation 2012;125(18):2222-31.
2012: Robert E Gerszten; Andrew M Tager
The monocyte in atherosclerosis--should I stay or should I go now?
The New England journal of medicine 2012;366(18):1734-6.
2012: Lee D Roberts; Amanda L Souza; Robert E Gerszten; Clary B Clish
Targeted metabolomics.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2012;Chapter 30():Unit 30.2.1-24.
2012: Tim Ahfeldt; Heba Al-Siddiqi; Raymond Camahort; Clary B Clish; Alicia Cowley; Rahul C Deo; Robert E Gerszten; David Hendrickson; Adam Kaplan; Frank H Lau; Youn-Kyoung Lee; David H Lum; Greg Mowrer; Kiran Musunuru; Matthias Nahrendorf; Eugene P Rhee; John L Rinn; Robert T Schinzel; Jennifer Shay; Tony Shen; Fang Xia; Chad A Cowan
Programming human pluripotent stem cells into white and brown adipocytes.
Nature cell biology 2012;14(2):209-19.
2011: Dongxiao Shen; Sumita Sinha; Thomas J T Anderson; Lan Cheng; Ethan David Cohen; Shoukat Dedhar; John J Lepore; Jian Li; Alexander Y Lin; Michael S Parmacek; Jesse D Roberts; Robert E Gerszten
Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells.
Circulation research 2011;109(6):616-28.
2011: Robert E Gerszten; Aarti Asnani; Steven A Carr
Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.
Circulation research 2011;109(4):463-74.
2011: Robert E Gerszten; Thomas J Wang
Two roads diverge: weight loss interventions and circulating amino acids.
Science translational medicine 2011;3(80):80ps15.
2011: Thomas J Wang; Martin G Larson; Ramachandran S Vasan; Susan Cheng; Eugene P Rhee; Elizabeth McCabe; Gregory D Lewis; Caroline S Fox; Paul F Jacques; Céline Fernandez; Christopher J O'Donnell; Stephen A Carr; Vamsi K Mootha; Jose C Florez; Amanda Souza; Olle Melander; Clary B Clish; Robert E Gerszten
Metabolite profiles and the risk of developing diabetes.
Nature medicine 2011;17(4):448-53.
2011: Eugene P Rhee; Susan Cheng; Martin G Larson; Geoffrey A Walford; Gregory D Lewis; Elizabeth McCabe; Elaine Yang; Laurie Farrell; Caroline S Fox; Christopher J O'Donnell; Steven A Carr; Ramachandran S Vasan; Jose C Florez; Clary B Clish; Thomas J Wang; Robert E Gerszten
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.
The Journal of clinical investigation 2011;121(4):1402-11.
2011: V Rottiers; L Zhong; S H Najafi-Shoushtari; N Bardeesy; D E Cohen; Robert E Gerszten; S Gurumurthy; F Kristo; Y Li; Raul Mostoslavsky; Anders M Näär
MicroRNAs in metabolism and metabolic diseases.
Cold Spring Harbor symposia on quantitative biology 2011;76():225-33.
2010: S Hani Najafi-Shoushtari; Fjoralba Kristo; Yingxia Li; Toshi Shioda; David E Cohen; Robert E Gerszten; Anders M Näär
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.
Science (New York, N.Y.) 2010;328(5985):1566-9.
2010: Eugene P Rhee; Amanda Souza; Laurie Farrell; Martin R Pollak; Gregory D Lewis; David J R Steele; Ravi Thadhani; Clary B Clish; Anna Greka; Robert E Gerszten
Metabolite profiling identifies markers of uremia.
Journal of the American Society of Nephrology : JASN 2010;21(6):1041-1051.
2010: Gregory D Lewis; Laurie Farrell; Malissa J Wood; Maryann Martinovic; Zoltan Arany; Glenn C Rowe; Amanda Souza; Susan Cheng; Elizabeth L McCabe; Elaine Yang; Xu Shi; Rahul Deo; Frederick P Roth; Aarti Asnani; Eugene P Rhee; David M Systrom; Marc J Semigran; Ramachandran S Vasan; Steven A Carr; Thomas J Wang; Marc S Sabatine; Clary B Clish; Robert E Gerszten
Metabolic signatures of exercise in human plasma.
Science translational medicine 2010;2(33):33ra37.
2010: Fjoralba Kristo; Gregory J Hardy; Thomas J T Anderson; Sumita Sinha; Neil Ahluwalia; Alexander Y Lin; Jonathan Passeri; Marielle Scherrer-Crosbie; Robert E Gerszten
Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation.
Atherosclerosis 2010;210(1):107-13.
2010: Rahul C Deo; Luke Hunter; Gregory D Lewis; Guillaume Pare; Ramachandran S Vasan; Daniel Chasman; Thomas J Wang; Robert E Gerszten; Frederick P Roth
Interpreting metabolomic profiles using unbiased pathway models.
PLoS computational biology 2010;6(2):e1000692.
2010: Robert E Gerszten; Steven A Carr; Marc S Sabatine
Integration of proteomic-based tools for improved biomarkers of myocardial injury.
Clinical chemistry 2010;56(2):194-201.
2009: Robert E Gerszten; Marc Sabatine; Thomas J Wang
New antibody assays for cardiovascular disease: future tools for the clinical chemist?
Clinical chemistry 2009;55(3):404-6.
2008: Gregory D Lewis; Ru Wei; Emerson Liu; Elaine Yang; Xu Shi; Maryann Martinovic; Laurie Farrell; Aarti Asnani; Marcoli Cyrille; Arvind Ramanathan; Oded Shaham; Gabriel Berriz; Patricia A Lowry; Igor F Palacios; Murat Taşan; Frederick P Roth; Jiangyong Min; Christian Baumgartner; Hasmik Keshishian; Terri Addona; Vamsi K Mootha; Anthony Rosenzweig; Steven A Carr; Michael A Fifer; Marc S Sabatine; Robert E Gerszten
Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury.
The Journal of clinical investigation 2008;118(10):3503-12.
2008: Donald B Bloch; Thomas J Wang; Robert E Gerszten
Novel antibody markers of unstable atherosclerotic lesions.
The Journal of clinical investigation 2008;118(8):2675-7.
2008: Gregory D Lewis; Aarti Asnani; Robert E Gerszten
Application of metabolomics to cardiovascular biomarker and pathway discovery.
Journal of the American College of Cardiology 2008;52(2):117-23.
2008: Robert E Gerszten; Frank Accurso; gordon bernard; Richard M Caprioli; Eric W Klee; George G Klee; Iftikhar Kullo; Theresa A Laguna; Frederick P Roth; Marc S Sabatine; Pothur Srinivas; Thomas J Wang; Lorraine B Ware
Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs.
American journal of physiology. Lung cellular and molecular physiology 2008;295(1):L16-22.
2008: Marc S Sabatine; David A Morrow; Luke J Higgins; Catherine MacGillivray; Wei Guo; Christophe Bode; Nader Rifai; Christopher P Cannon; Robert E Gerszten; Richard T Lee
Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction.
Circulation 2008;117(15):1936-44.
2008: Heather R Christofk; Matthew G Vander Heiden; Marian H Harris; Arvind Ramanathan; Robert E Gerszten; Ru Wei; Mark D Fleming; Stuart L Schreiber; Lewis C Cantley
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Nature 2008;452(7184):230-3.
2008: Moritz Kircher; Jan Grimm; Filip K Swirski; Peter Libby; Robert E Gerszten; Jennifer R Allport; Ralph Weissleder
Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions.
Circulation 2008;117(3):388-95.
2007: Gregory D Lewis; Ravi Shah; Khurram Shahzad; Janice M Camuso; Paul P Pappagianopoulos; Judy Hung; Ahmed Tawakol; Robert E Gerszten; David M Systrom; Kenneth D Bloch; Marc J Semigran
Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension.
Circulation 2007;116(14):1555-62.
2007: Neil Ahluwalia; Alexander Y Lin; Andrew M Tager; Ivy E Pruitt; Thomas J T Anderson; Fjoralba Kristo; Dongxiao Shen; Anna R Cruz; Masanori Aikawa; Andrew D Luster; Robert E Gerszten
Inhibited aortic aneurysm formation in BLT1-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):691-7.
2007: Kimberly A Kelly; Jennifer R Allport; Amy M Yu; Sumita Sinh; E Helene Sage; Robert E Gerszten; Ralph Weissleder
SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
Journal of leukocyte biology 2007;81(3):748-56.
2007: Savita V Dandapani; Hikaru Sugimoto; Benjamin D Matthews; Robert J Kolb; Sumita Sinha; Robert E Gerszten; Jing Zhou; Donald Ingber; Raghu Kalluri; Martin R Pollak
Alpha-actinin-4 is required for normal podocyte adhesion.
The Journal of biological chemistry 2007;282(1):467-77.
2006: Eric A Heller; Emerson Liu; Andrew M Tager; Qian Yuan; Alexander Y Lin; Neil Ahluwalia; Krister Jones; Stephanie L Koehn; Vincent M Lok; Elena Aikawa; Kathryn J Moore; Andrew D Luster; Robert E Gerszten
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.
Circulation 2006;113(19):2301-12.
2005: Marc S Sabatine; Emerson Liu; David A Morrow; Eric Heller; Robert McCarroll; Roger Wiegand; Gabriel F Berriz; Frederick P Roth; Robert E Gerszten
Metabolomic identification of novel biomarkers of myocardial ischemia.
Circulation 2005;112(25):3868-75.
2005: Emerson Liu; Sumita Sinha; Christine Williams; Marcoli Cyrille; Eric Heller; Scott B Snapper; Katia Georgopoulos; René St-Arnaud; Thomas Force; Shoukat Dedhar; Robert E Gerszten
Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival.
Molecular and cellular biology 2005;25(24):11145-55.
2005: Eric A Heller; Emerson Liu; Andrew M Tager; Sumita Sinha; Jesse D Roberts; Stephanie L Koehn; Peter Libby; Elena Aikawa; Ji Qiu Chen; Paul Huang; Mason W Freeman; Kathryn J Moore; Andrew D Luster; Robert E Gerszten
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.
Circulation 2005;112(4):578-86.
2005: Vivek R Shinde Patil; Erik B Friedrich; Allison E Wolley; Robert E Gerszten; Jennifer R Allport; Ralph Weissleder
Bone marrow-derived lin(-)c-kit(+)Sca-1+ stem cells do not contribute to vasculogenesis in Lewis lung carcinoma.
Neoplasia (New York, N.Y.) 2005;7(3):234-40.
2004: Erik B Friedrich; Emerson Liu; Sumita Sinha; Stuart Cook; David S Milstone; Calum A MacRae; Massimo Mariotti; Peter J Kuhlencordt; Thomas Force; Anthony Rosenzweig; René St-Arnaud; Shoukat Dedhar; Robert E Gerszten
Integrin-linked kinase regulates endothelial cell survival and vascular development.
Molecular and cellular biology 2004;24(18):8134-44.
2004: Peter J Kuhlencordt; Eva Rosel; Robert E Gerszten; Manuel Morales-Ruiz; David Dombkowski; William J Atkinson; Fred Han; Frederic Preffer; Anthony Rosenzweig; William C Sessa; Michael A Gimbrone; Georg Ertl; Paul L Huang
Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells.
American journal of physiology. Cell physiology 2004;286(5):C1195-202.
2003: Andrew M Tager; Shannon K Bromley; Benjamin D Medoff; Sabina A Islam; Scott D Bercury; Erik B Friedrich; Andrew D Carafone; Robert E Gerszten; Andrew D Luster
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment.
Nature immunology 2003;4(10):982-90.
2003: Erik B Friedrich; Andrew M Tager; Emerson Liu; Annika Pettersson; Christer Owman; Lance L Munn; Andrew D Luster; Robert E Gerszten
Mechanisms of leukotriene B4--triggered monocyte adhesion.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1761-7.
2003: Claudine H Kos; Tu Cam Le; Sumita Sinha; Joel M Henderson; Sung Han Kim; Hikaru Sugimoto; Raghu Kalluri; Robert E Gerszten; Martin R Pollak
Mice deficient in alpha-actinin-4 have severe glomerular disease.
The Journal of clinical investigation 2003;111(11):1683-90.
2002: Farouc A Jaffer; Ching-Hsuan Tung; Robert E Gerszten; Ralph Weissleder
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(11):1929-35.
2002: Erik B Friedrich; Sumita Sinha; Ling Li; Shoukat Dedhar; Thomas Force; Anthony Rosenzweig; Robert E Gerszten
Role of integrin-linked kinase in leukocyte recruitment.
The Journal of biological chemistry 2002;277(19):16371-5.
2002: Steffen E. Meiler; Rebecca R Hung; Robert E Gerszten; Jacopo Gianetti; Ling Li; Takashi Matsui; Michael A Gimbrone; Anthony Rosenzweig
Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions.
Journal of molecular and cellular cardiology 2002;34(3):349-59.
2002: Ching-Hsuan Tung; Robert E Gerszten; Farouc A Jaffer; Ralph Weissleder
A novel near-infrared fluorescence sensor for detection of thrombin activation in blood.
Chembiochem : a European journal of chemical biology 2002;3(2-3):207-11.
2001: Robert E Gerszten; Erik B Friedrich; Takashi Matsui; R R Hung; Ling Li; Thomas Force; Anthony Rosenzweig
Role of phosphoinositide 3-kinase in monocyte recruitment under flow conditions.
The Journal of biological chemistry 2001;276(29):26846-51.
2001: Masayuki Yoshida; T Sawada; Hiromasa Ishii; Robert E Gerszten; Anthony Rosenzweig; Michael A Gimbrone; Y Yasukochi; Fujio Numano
Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(7):1165-71.
2000: Robert E Gerszten; F Mach; Alain Sauty; Anthony Rosenzweig; Andrew D Luster
Chemokines, leukocytes, and atherosclerosis.
The Journal of laboratory and clinical medicine 2000;136(2):87-92.
2000: Francis W Luscinskas; Robert E Gerszten; EDUARDO GARCIA-ZEPEDA; Yaw-Chyn Lim; Masayuki Yoshida; H A Ding; Michael A Gimbrone; Andrew D Luster; Anthony Rosenzweig
C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions.
Annals of the New York Academy of Sciences 2000;902():288-93.
1999: Robert E Gerszten; EDUARDO GARCIA-ZEPEDA; Yaw-Chyn Lim; Masayuki Yoshida; H A Ding; Michael A Gimbrone; Andrew D Luster; Francis W Luscinskas; Anthony Rosenzweig
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.
Nature 1999;398(6729):718-23.
1998: Robert E Gerszten; Yaw-Chyn Lim; H T Ding; Karen R. Snapp; Geoffrey S Kansas; D A Dichek; C Cabañas; Francisco Sánchez-Madrid; Michael A Gimbrone; Anthony Rosenzweig; Francis W Luscinskas
Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis.
Circulation research 1998;82(8):871-8.
1996: Robert E Gerszten; Francis W Luscinskas; H T Ding; D A Dichek; Lloyd M Stoolman; Michael A Gimbrone; Anthony Rosenzweig
Adhesion of memory lymphocytes to vascular cell adhesion molecule-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro.
Circulation research 1996;79(6):1205-15.