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Arieh Gertler

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Yacir Benomar; Delphine Crépin; Pamela De Lacy; Arieh Gertler; Hassina Ould Hamouda; Laure Riffault; Mohammed Taouis
Central resistin overexposure induces insulin resistance through Toll-like receptor 4.
Leonora Niv-Spector; Michal Shpilman; Chen Varol; Eran Elinav; Meirav Katz; Mariela Levi-Bober; Arieh Gertler
Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists.
Odile Couvreur; Delphine Crépin; Jéril Degrouard; Arieh Gertler; Mohammed Taouis; Alain Aubourg; Claire-Marie Vacher
The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons.

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All Publications

2013: Yacir Benomar; Delphine Crépin; Pamela De Lacy; Arieh Gertler; Hassina Ould Hamouda; Laure Riffault; Mohammed Taouis
Central resistin overexposure induces insulin resistance through Toll-like receptor 4.
Diabetes 2013;62(1):102-14.
2012: Leonora Niv-Spector; Michal Shpilman; Chen Varol; Eran Elinav; Meirav Katz; Mariela Levi-Bober; Arieh Gertler
Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists.
Protein engineering, design & selection : PEDS 2012;25(8):397-404.
2012: Odile Couvreur; Delphine Crépin; Jéril Degrouard; Arieh Gertler; Mohammed Taouis; Alain Aubourg; Claire-Marie Vacher
The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons.
American journal of physiology. Endocrinology and metabolism 2012;302(4):E458-67.
2012: Leonora Niv-Spector; Michal Shpilman; Yves Boisclair; Arieh Gertler
Large-scale preparation and characterization of non-pegylated and pegylated superactive ovine leptin antagonist.
Protein expression and purification 2012;81(2):186-92.
2012: shay reicher; Y R Boisclair; E Gootwine; S M Hileman; J M Ramos-Nieves; Arieh Gertler
Nonsynonymous natural genetic polymorphisms in the bovine leptin gene affect biochemical and biological characteristics of the mature hormone.
Journal of animal science 2012;90(2):410-8.
2011: shay reicher; Eyal Seroussi; Michal Shpilman; Arieh Gertler; E Gootwine
Biochemical and in vitro biological significance of natural sequence variation in the ovine leptin gene.
General and comparative endocrinology 2011;173(1):63-71.
2011: Anna Hrabia; Arieh Gertler; Andrzej Sechman; Janusz Rząsa
Effect of growth hormone on steroid content, proliferation and apoptosis in the chicken ovary during sexual maturation.
Cell and tissue research 2011;345(1):191-202.
2011: Sigal Samuel-Mendelsohn; Michal Inbar; Esther Weiss-Messer; Leonora Niv-Spector; Arieh Gertler; Ronnie J Barkey
Leptin signaling and apoptotic effects in human prostate cancer cell lines.
The Prostate 2011;71(9):929-45.
2011: Flavien Berthou; Claude Rouch; Arieh Gertler; Kyriaki Gerozissis; Mohammed Taouis
Chronic central leptin infusion differently modulates brain and liver insulin signaling.
Molecular and cellular endocrinology 2011;337(1-2):89-95.
2011: Linda Attig; Arieh Gertler; Thibaut Larcher; Latifa Abdennebi-Najar; Jean Djiane
Postnatal leptin is necessary for maturation of numerous organs in newborn rats.
Organogenesis 2011;7(2):88-94.
2011: Michal Shpilman; Leonora Niv-Spector; Meirav Katz; Chen Varol; Gili Solomon; Michal Ayalon-Soffer; Eric Boder; Zamir Halpern; Eran Elinav; Arieh Gertler
Development and characterization of high affinity leptins and leptin antagonists.
The Journal of biological chemistry 2011;286(6):4429-42.
2011: Odile Couvreur; Jacqueline Ferezou; Daniel Gripois; Colette Serougne; Delphine Crépin; Alain Aubourg; Arieh Gertler; Claire-Marie Vacher; Mohammed Taouis
Unexpected long-term protection of adult offspring born to high-fat fed dams against obesity induced by a sucrose-rich diet.
PloS one 2011;6(3):e18043.
2010: Leonora Niv-Spector; Michal Shpilman; Asaf Grupi; Arieh Gertler
The obese phenotype-inducing N82K mutation in human leptin disrupts receptor-binding and biological activity.
Molecular genetics and metabolism 2010;100(2):193-7.
2010: E Ons; Arieh Gertler; Johan Buyse; E Lebihan-Duval; A Bordas; Bruno Goddeeris; Sami Dridi
Visfatin gene expression in chickens is sex and tissue dependent.
Domestic animal endocrinology 2010;38(2):63-74.
2009: Eran Elinav; Leonora Niv-Spector; Meirav Katz; Tulin O Price; Mohammed Ali; Michal Yacobovitz; Gili Solomon; shay reicher; Jessica L Lynch; Zamir Halpern; William A Banks; Arieh Gertler
Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity.
Endocrinology 2009;150(7):3083-91.
2009: Yacir Benomar; Flavien Berthou; Claire-Marie Vacher; Virginie Bailleux; Arieh Gertler; Jean Djiane; Mohammed Taouis
Leptin but not ciliary neurotrophic factor (CNTF) induces phosphotyrosine phosphatase-1B expression in human neuronal cells (SH-SY5Y): putative explanation of CNTF efficacy in leptin-resistant state.
Endocrinology 2009;150(3):1182-91.
2008: Shelley Klompus; Gila Solomon; Arieh Gertler
A simple novel method for the preparation of noncovalent homodimeric, biologically active human interleukin 10 in Escherichia coli-enhancing protein expression by degenerate PCR of 5' DNA in the open reading frame.
Protein expression and purification 2008;62(2):199-205.
2008: C-M Vacher; D Crépin; Alain Aubourg; O Couvreur; Virginie Bailleux; V Nicolas; Jacqueline Férézou; Daniel Gripois; Arieh Gertler; Mohammed Taouis
A putative physiological role of hypothalamic CNTF in the control of energy homeostasis.
FEBS letters 2008;582(27):3832-8.
2008: M Yacobovitz; G Solomon; E E Gusakovsky; Berta Levavi-Sivan; Arieh Gertler
Purification and characterization of recombinant pufferfish (Takifugu rubripes) leptin.
General and comparative endocrinology 2008;156(1):83-90.
2008: shay reicher; Leonora Niv-Spector; Arieh Gertler; E Gootwine
Pituitary and placental ovine growth hormone variants differ in their receptor-binding ability and in their biological properties.
General and comparative endocrinology 2008;155(2):368-77.
2007: Anne-France Roy; Yacir Benomar; Virginie Bailleux; C M Vacher; Alain Aubourg; Arieh Gertler; Jean Djiane; Mohammed Taouis
Lack of cross-desensitization between leptin and prolactin signaling pathways despite the induction of suppressor of cytokine signaling 3 and PTP-1B.
The Journal of endocrinology 2007;195(2):341-50.
2007: Jacqueline Férézou-Viala; Anne-France Roy; Colette Sérougne; Daniel Gripois; Michel Parquet; Virginie Bailleux; Arieh Gertler; Bernadette Delplanque; Jean Djiane; Michel Riottot; Mohammed Taouis
Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R1056-62.
2007: Denise Figueiredo; Arieh Gertler; Gérard Cabello; Eddy Decuypere; Johan Buyse; Sami Dridi
Leptin downregulates heat shock protein-70 (HSP-70) gene expression in chicken liver and hypothalamus.
Cell and tissue research 2007;329(1):91-101.
2007: Sami Dridi; Mohammed Taouis; Arieh Gertler; Eddy Decuypere; Johan Buyse
The regulation of stearoyl-CoA desaturase gene expression is tissue specific in chickens.
The Journal of endocrinology 2007;192(1):229-36.
2007: Arieh Gertler; Leonora Niv-Spector; shay reicher
Is leptin an important physiological regulator of CRP?
Nature medicine 2007;13(1):18-9; author reply 19-21.
2006: Gili Solomon; Leonora Niv-Spector; Dana Gonen-Berger; Isabelle Callebaut; Jean Djiane; Arieh Gertler
Preparation of leptin antagonists by site-directed mutagenesis of human, ovine, rat, and mouse leptin's site III: implications on blocking undesired leptin action in vivo.
Annals of the New York Academy of Sciences 2006;1091():531-9.
2006: Helena Elzbieta Paczoska-Eliasiewicz; Gili Salomon; shay reicher; Eugene E Gussakowsky; Anna Hrabia; Arieh Gertler
Preparation and characterization of recombinant chicken growth hormone (chGH) and its putative antagonist chGH G119R mutein.
Annals of the New York Academy of Sciences 2006;1091():501-8.
2006: Arieh Gertler
Development of leptin antagonists and their potential use in experimental biology and medicine.
Trends in endocrinology and metabolism: TEM 2006;17(9):372-8.
2006: G Solomon; shay reicher; Eugene E Gussakovsky; J-Baptiste Jomain; Arieh Gertler
Large-scale preparation and in vitro characterization of biologically active human placental (20 and 22K) and pituitary (20K) growth hormones: placental growth hormones have no lactogenic activity in humans.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2006;16(5-6):297-307.
2006: Helena Elzbieta Paczoska-Eliasiewicz; Monika Proszkowiec-Weglarz; John Proudman; Tomasz Jacek; Maria Mika; Andrzej Sechman; Janusz Rzasa; Arieh Gertler
Exogenous leptin advances puberty in domestic hen.
Domestic animal endocrinology 2006;31(3):211-26.
2006: Eva Biener-Ramanujan; V Krishnan Ramanujan; Brian Herman; Arieh Gertler
Spatio-temporal kinetics of growth hormone receptor signaling in single cells using FRET microscopy.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2006;16(4):247-57.
2006: Yacir Benomar; Nadia Naour; Alain Aubourg; Virginie Bailleux; Arieh Gertler; Jean Djiane; Michèle Guerre-Millo; Mohammed Taouis
Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism.
Endocrinology 2006;147(5):2550-6.
2006: Gili Salomon; Leonora Niv-Spector; Eugene E Gussakovsky; Arieh Gertler
Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists.
Protein expression and purification 2006;47(1):128-36.
2006: Arieh Gertler
Bacterial expression of prolactin family proteins.
Methods in molecular medicine 2006;122():341-54.
2005: Yossi Dagon; Yosefa Avraham; Iddo Magen; Arieh Gertler; Tamir Ben-Hur; Elliot M Berry
Nutritional status, cognition, and survival: a new role for leptin and AMP kinase.
The Journal of biological chemistry 2005;280(51):42142-8.
2005: Eva Biener; Madia Charlier; V Krishnan Ramanujan; Nathalie Daniel; Avital Eisenberg; Christian Bjørbaek; Brian Herman; Arieh Gertler; Jean Djiane
Quantitative FRET imaging of leptin receptor oligomerization kinetics in single cells.
Biology of the cell / under the auspices of the European Cell Biology Organization 2005;97(12):905-19.
2005: Leonora Niv-Spector; Dana Gonen-Berger; Isabelle Gourdou; Eva Biener; Eugene E Gussakovsky; Yacir Benomar; Krishnan V Ramanujan; Mohammed Taouis; Brian Herman; Isabelle Callebaut; Jean Djiane; Arieh Gertler
Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists.
The Biochemical journal 2005;391(Pt 2):221-30.
2005: Leonora Niv-Spector; Nina Raver; M Friedman-Einat; Jeanne Grosclaude; Eugene E Gussakovsky; Oded Livnah; Arieh Gertler
Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor.
The Biochemical journal 2005;390(Pt 2):475-84.
2005: Nele Martens; Galit Uzan; Maxime Wery; Robert Hooghe; Elisabeth L Hooghe-Peters; Arieh Gertler
Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.
The Journal of biological chemistry 2005;280(14):13817-23.
2005: Arieh Gertler; Eva Biener; Krishnan V Ramanujan; Jean Djiane; Brian Herman
Fluorescence resonance energy transfer (FRET) microscopy in living cells as a novel tool for the study of cytokine action.
The Journal of dairy research 2005;72 Spec No():14-9.
2004: Sarah Maurice; Amos Nussinovitch; Nicole Jaffe; Oded Shoseyov; Arieh Gertler
Oral immunization of Carassius auratus with modified recombinant A-layer proteins entrapped in alginate beads.
Vaccine 2004;23(4):450-9.
2004: Nele Martens; Maxime Wery; Ping Wang; Filip Braet; Arieh Gertler; Robert Hooghe; Jean Vandenhaute; Elisabeth L Hooghe-Peters
The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin.
Experimental cell research 2004;298(1):239-48.
2004: Avital Eisenberg; Eva Biener; Madia Charlier; R Venkata Krishnan; Jean Djiane; Brian Herman; Arieh Gertler
Transactivation of erbB2 by short and long isoforms of leptin receptors.
FEBS letters 2004;565(1-3):139-42.
2004: MR Garcia; Marcel Amstalden; Duane Keisler; Nina Raver; Arieh Gertler; Gary L Williams
Leptin attenuates the acute effects of centrally administered neuropeptide Y on somatotropin but not gonadotropin secretion in ovariectomized cows.
Domestic animal endocrinology 2004;26(3):189-200.
2003: Helena Elzbieta Paczoska-Eliasiewicz; Arieh Gertler; M Proszkowiec; J Proudman; Anna Hrabia; Andrzej Sechman; Maria Mika; Tomasz Jacek; Sandrine Cassy; Nina Raver; Janusz Rzasa
Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus).
Reproduction (Cambridge, England) 2003;126(6):739-51.
2003: Eva Biener; Cyril Martin; Nathalie Daniel; Stuart J Frank; Victoria Frohlich; Brian Herman; Jean Djiane; Arieh Gertler
Ovine placental lactogen-induced heterodimerization of ovine growth hormone and prolactin receptors in living cells is demonstrated by fluorescence resonance energy transfer microscopy and leads to prolonged phosphorylation of signal transducer and activator of transcription (STAT)1 and STAT3.
Endocrinology 2003;144(8):3532-40.
2003: Jolanta Kolodziejczyk; Arieh Gertler; Haim Leibovich; Janusz Rzasa; Ewa L Gregoraszczuk
Synergistic action of growth hormone and insulin-like growth factor I (IGF-I) on proliferation and estradiol secretion in porcine granulosa and theca cells cultured alone or in coculture.
Theriogenology 2003;60(3):559-70.
2003: Sarah Maurice; Mara Dekel; Oded Shoseyov; Arieh Gertler
Cellulose beads bound to cellulose binding domain-fused recombinant proteins; an adjuvant system for parenteral vaccination of fish.
Vaccine 2003;21(23):3200-7.
2003: Dorota Zieba; Marcel Amstalden; Marlon N Maciel; Duane Keisler; Nina Raver; Arieh Gertler; Gary L Williams
Divergent effects of leptin on luteinizing hormone and insulin secretion are dose dependent.
Experimental biology and medicine (Maywood, N.J.) 2003;228(3):325-30.
2003: Sekoni Noel; Asael Herman; Greg A Johnson; C Allison Gray; M David Stewart; Fuller W Bazer; Arieh Gertler; Thomas E Spencer
Ovine placental lactogen specifically binds to endometrial glands of the ovine uterus.
Biology of reproduction 2003;68(3):772-80.
2003: Karen D Carpenter; C Allison Gray; Sekoni Noel; Arieh Gertler; Fuller W Bazer; Thomas E Spencer
Prolactin regulation of neonatal ovine uterine gland morphogenesis.
Endocrinology 2003;144(1):110-20.
2002: Yael Sandowski; Nina Raver; Eugene E Gussakovsky; Suzan Shochat; Orly Dym; Oded Livnah; Menachem Rubinstein; Radha Krishna; Arieh Gertler
Subcloning, expression, purification, and characterization of recombinant human leptin-binding domain.
The Journal of biological chemistry 2002;277(48):46304-9.
2002: Liora Ben-Yair; Rita Slaaby; Asael Herman; Yael Cohen; Eva Biener; Nava Moran; Akihiko Yoshimura; Jonathan Whittaker; Pierre De Meyts; Brian Herman; Arieh Gertler
Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins.
Protein expression and purification 2002;25(3):456-64.
2002: Eva Biener; Sarah Maurice; Yael Sandowski; Yael Cohen; Eugene E Gusakowsky; Robert Hooghe; Akihiko Yoshimura; Oded Livnah; Arieh Gertler
Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization.
Protein expression and purification 2002;25(2):305-12.
2002: Felix G Ayson; Evelyn Grace T de Jesus; Shunsuke Moriyama; Susumu Hyodo; Bruria Funkenstein; Arieh Gertler; Hiroshi Kawauchi
Differential expression of insulin-like growth factor I and II mRNAs during embryogenesis and early larval development in rabbitfish, Siganus guttatus.
General and comparative endocrinology 2002;126(2):165-74.
2002: Nina Raver; Eyal Vardy; Oded Livnah; Rene Devos; Arieh Gertler
Comparison of R128Q mutations in human, ovine, and chicken leptins.
General and comparative endocrinology 2002;126(1):52-8.
2002: Arieh Gertler; Jean Djiane
Mechanism of ruminant placental lactogen action: molecular and in vivo studies.
Molecular genetics and metabolism 2002;75(3):189-201.
2001: Mohammed Taouis; Sami Dridi; Sandrine Cassy; Yacir Benomar; Nina Raver; Nicole Rideau; Michel Picard; J Williams; Arieh Gertler
Chicken leptin: properties and actions.
Domestic animal endocrinology 2001;21(4):319-27.
2001: Haim Leibovich; Nina Raver; A Herman; Ewa L Gregoraszczuk; E Gootwine; Arieh Gertler
Large-scale preparation of recombinant ovine prolactin and determination of its in vitro and in vivo activity.
Protein expression and purification 2001;22(3):489-96.
2001: J Kołodziejczyk; Ewa L Gregoraszczuk; Haim Leibovich; Arieh Gertler
Different action of ovine GH on porcine theca and granulosa cells proliferation and insulin-like growth factors I- and II-stimulated estradiol production.
Reproductive biology 2001;1(1):33-41.
2001: D Helman; A Herman; Jacqueline Paly; Oded Livnah; PA Elkins; Abraham M de Vos; Jean Djiane; Arieh Gertler
Mutations of ovine and bovine placental lactogens change, in different ways, the biological activity mediated through homologous and heterologous lactogenic receptors.
The Journal of endocrinology 2001;169(1):43-54.
2001: P L Rouzic; Olivier Sandra; Jeanne Grosclaude; F Rentier-Delrue; O Jolois; M Tujague; pakdel farzad; Yael Sandowski; Yael Cohen; Arieh Gertler; Patrick Prunet
Evidence of rainbow trout prolactin interaction with its receptor through unstable homodimerisation.
Molecular and cellular endocrinology 2001;172(1-2):105-13.
2001: Christopher D Morrison; Joseph A Daniel; B J Holmberg; Jean Djiane; Nina Raver; Arieh Gertler; Duane Keisler
Central infusion of leptin into well-fed and undernourished ewe lambs: effects on feed intake and serum concentrations of growth hormone and luteinizing hormone.
The Journal of endocrinology 2001;168(2):317-24.
2000: Haim Leibovich; Arieh Gertler; Fuller W Bazer; E Gootwine
Active immunization of ewes against ovine placental lactogen increases birth weight of lambs and milk production with no adverse effect on conception rate.
Animal reproduction science 2000;64(1-2):33-47.
2000: PA Elkins; Hans W Christinger; Yael Sandowski; E Sakal; Arieh Gertler; Abraham M de Vos; Anthony A Kossiakoff
Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nature structural biology 2000;7(9):808-15.
2000: Sami Dridi; Nina Raver; Eugene E Gussakovsky; Michel Derouet; Michel Picard; Arieh Gertler; Mohammed Taouis
Biological activities of recombinant chicken leptin C4S analog compared with unmodified leptins.
American journal of physiology. Endocrinology and metabolism 2000;279(1):E116-23.
2000: Nina Raver; Eugene E Gussakovsky; Duane Keisler; R Krishna; J Mistry; Arieh Gertler
Preparation of recombinant bovine, porcine, and porcine W4R/R5K leptins and comparison of their activity and immunoreactivity with ovine, chicken, and human leptins.
Protein expression and purification 2000;19(1):30-40.
2000: Yael Sandowski; Yael Cohen; P Le Rouzic; C Bignon; F Rentier-Delrue; Jean Djiane; Patrick Prunet; Arieh Gertler
Recombinant prolactin receptor extracellular domain of rainbow trout (Oncorhynchus mykiss): subcloning, preparation, and characterization.
General and comparative endocrinology 2000;118(2):302-9.
2000: Carole Delavaud; François Bocquier; Yves Chilliard; Duane Keisler; Arieh Gertler; G Kann
Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep.
The Journal of endocrinology 2000;165(2):519-26.
2000: E Sakal; N Chapnik-Cohen; Lucette Belair; Jean Djiane; Arieh Gertler
Recombinant extracellular domain of rabbit growth hormone receptor and biological activity of somatogenic hormones.
Preparative biochemistry & biotechnology 2000;30(2):107-23.
2000: Sami Dridi; J Williams; V Bruggeman; M Onagbesan; Nina Raver; Eddy Decuypere; Jean Djiane; Arieh Gertler; Mohammed Taouis
A chicken leptin-specific radioimmunoassay.
Domestic animal endocrinology 2000;18(3):325-35.
2000: A Herman; C Bignon; Nathalie Daniel; Jeanne Grosclaude; Arieh Gertler; Jean Djiane
Functional heterodimerization of prolactin and growth hormone receptors by ovine placental lactogen.
The Journal of biological chemistry 2000;275(9):6295-301.
2000: Ewa L Gregoraszczuk; Dorota Zieba; E Wierzchoś; Maciej Murawski; Arieh Gertler
Placental lactogen as a regulator of luteal cells function during pregnancy in sheep.
Theriogenology 2000;53(4):877-85.
2000: Ewa L Gregoraszczuk; A Bylica; Arieh Gertler
Response of porcine theca and granulosa cells to GH during short-term in vitro culture.
Animal reproduction science 2000;58(1-2):113-25.
2000: Ewa L Gregoraszczuk; Arieh Gertler; E Futoma
Effect of exogenous ovine placental lactogen on basal and prostaglandin-stimulated progesterone production by porcine luteal cells.
Acta veterinaria Hungarica 2000;48(2):199-208.
2000: E Wierzchoś; Ewa L Gregoraszczuk; Dorota Zieba; Maciej Murawski; Arieh Gertler
Placental lactogen not growth hormone and prolactin regulates secretion of progesterone in vitro by the 40-45 day ovine corpus luteum of pregnancy.
Folia biologica 2000;48(1-2):19-24.
1999: Thomas E Spencer; A Gray; Greg A Johnson; KM Taylor; Arieh Gertler; E Gootwine; Troy L Ott; Fuller W Bazer
Effects of recombinant ovine interferon tau, placental lactogen, and growth hormone on the ovine uterus.
Biology of reproduction 1999;61(6):1409-18.
1999: A Paduel; N Chapnik-Cohen; Arieh Gertler; A Elizur
Preparation and characterization of recombinant dolphin fish (Coryphaena hippurus) growth hormone.
Protein expression and purification 1999;16(3):417-23.
1999: Sarah Maurice; D Hädge; Mara Dekel; A Friedman; Arieh Gertler; Oded Shoseyov
A-protein from achromogenic atypical Aeromonas salmonicida: molecular cloning, expression, purification, and characterization.
Protein expression and purification 1999;16(3):396-404.
1999: A Herman; D Helman; Oded Livnah; Arieh Gertler
Ruminant placental lactogens act as antagonists to homologous growth hormone receptors and as agonists to human or rabbit growth hormone receptors.
The Journal of biological chemistry 1999;274(12):7631-9.
1999: G Kann; A Delobelle-Deroide; Lucette Belair; Arieh Gertler; Jean Djiane
Demonstration of in vivo mammogenic and lactogenic effects of recombinant ovine placental lactogen and mammogenic effect of recombinant ovine GH in ewes during artificial induction of lactation.
The Journal of endocrinology 1999;160(3):365-77.
1999: I Ben-Atia; M Fine; A Tandler; Bruria Funkenstein; S Maurice; B Cavari; Arieh Gertler
Preparation of recombinant gilthead seabream (Sparus aurata) growth hormone and its use for stimulation of larvae growth by oral administration.
General and comparative endocrinology 1999;113(1):155-64.
1998: D Helman; Yael Sandowski; Yael Cohen; A Matsumoto; Akihiko Yoshimura; S Merchav; Arieh Gertler
Cytokine-inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor-mediated STAT5 signaling.
FEBS letters 1998;441(2):287-91.
1998: Nina Raver; Mohammed Taouis; Sami Dridi; Michel Derouet; J Simon; B Robinzon; Jean Djiane; Arieh Gertler
Large-scale preparation of biologically active recombinant chicken obese protein (leptin).
Protein expression and purification 1998;14(3):403-8.
1998: E Sakal; C Bignon; N Chapnik-Cohen; Nathalie Daniel; Jacqueline Paly; Lucette Belair; Jean Djiane; Arieh Gertler
Cloning, preparation and characterization of biologically active recombinant caprine placental lactogen.
The Journal of endocrinology 1998;159(3):509-18.
1998: Hans W Christinger; PA Elkins; Yael Sandowski; E Sakal; Arieh Gertler; Anthony A Kossiakoff; Abraham M de Vos
Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 2):1408-11.
1998: D Helman; N R Staten; Jeanne Grosclaude; Nathalie Daniel; C Nespoulous; Jean Djiane; Arieh Gertler
Novel recombinant analogues of bovine placental lactogen. G133K and G133R provide a tool to understand the difference between the action of prolactin and growth hormone receptors.
The Journal of biological chemistry 1998;273(26):16067-74.
1998: Arieh Gertler; Jeanne Grosclaude; Jean Djiane
Interaction of lactogenic hormones with prolactin receptors.
Annals of the New York Academy of Sciences 1998;839():177-81.
1998: Arieh Gertler; J Simmons; Duane Keisler
Large-scale preparation of biologically active recombinant ovine obese protein (leptin).
FEBS letters 1998;422(2):137-40.
1997: D Helman; N R Staten; J Byatt; Jeanne Grosclaude; R E McKinnie; Jean Djiane; Arieh Gertler
Site-directed mutagenesis of recombinant bovine placental lactogen at lysine-73 leads to selective attenuation of its somatogenic activity.
Endocrinology 1997;138(10):4069-80.
1997: E Sakal; G Elberg; Arieh Gertler
Direct evidence that lactogenic hormones induce homodimerization of membrane-anchored prolactin receptor in intact Nb2-11C rat lymphoma cells.
FEBS letters 1997;410(2-3):289-92.
1997: A Tchelet; T Vogel; D Helman; R Guy; C Neospouolus; V Goffin; Jean Djiane; Arieh Gertler
Selective modification at the N-terminal region of human growth hormone that shows antagonistic activity.
Molecular and cellular endocrinology 1997;130(1-2):141-52.
1997: M Fine; R Amuly; Yael Sandowski; T A Marchant; SJ Chan; Arieh Gertler; Bruria Funkenstein
Recombinant gilthead seabream (Sparus aurata) insulin-like growth factor-I: subcloning, expression in Escherichia coli, purification and characterization.
The Journal of endocrinology 1997;153(1):139-50.
1997: E Sakal; C Bignon; Jeanne Grosclaude; A Kantor; Roni Shapira; H Leibovitch; D Helman; C Nespoulous; A Shamay; S W Rowlinson; Jean Djiane; Arieh Gertler
Large-scale preparation and characterization of recombinant ovine placental lactogen.
The Journal of endocrinology 1997;152(2):317-27.
1997: Arieh Gertler
Recombinant analogues of prolactin, growth hormone, and placental lactogen: correlations between physical structure, binding characteristics, and activity.
Journal of mammary gland biology and neoplasia 1997;2(1):69-80.
1996: Arieh Gertler; Jeanne Grosclaude; C J Strasburger; S Nir; Jean Djiane
Real-time kinetic measurements of the interactions between lactogenic hormones and prolactin-receptor extracellular domains from several species support the model of hormone-induced transient receptor dimerization.
The Journal of biological chemistry 1996;271(40):24482-91.
1996: D Vashdi-Elberg; N R Staten; E Sakal; R E McKinnie; Jean Djiane; G G Krivi; Arieh Gertler
Selective modification of recombinant bovine placental lactogen by site-directed mutagenesis at its C terminus.
The Journal of biological chemistry 1996;271(10):5558-64.
1996: G Elberg; M J Rapoport; D Vashdi-Elberg; Arieh Gertler; Yoram Shechter
Lactogenic hormones rapidly activate p21( ras )/mitogen-activated protein kinase in Nb2-11C rat lymphoma cells.
Endocrine 1996;4(1):65-71.
1996: E Sakal; M C Robertson; N Chapnik-Cohen; A Tchelet; Arieh Gertler
Interaction of recombinant rat placental lactogen-I with extracellular domains of prolactin receptors from three species.
Receptors & signal transduction 1996;6(1):35-42.
1995: Yael Sandowski; M Nagano; C Bignon; Jean Djiane; Paul A Kelly; Arieh Gertler
Preparation and characterization of recombinant prolactin receptor extracellular domain from rat.
Molecular and cellular endocrinology 1995;115(1):1-11.
1995: E Monsonego; O Halevy; Arieh Gertler; S Hurwitz; Mark Pines
Growth hormone inhibits differentiation of avian epiphyseal growth-plate chondrocytes.
Molecular and cellular endocrinology 1995;114(1-2):35-42.
1995: D Vashdi-Elberg; N R Staten; E Sakal; G G Krivi; Arieh Gertler
N-terminal-truncated recombinant analogs of bovine placental lactogen: interaction with human and rat growth hormone receptors and insulin-like growth factor-I secretion mediated by somatogenic receptors in rat hepatocytes.
Endocrinology 1995;136(3):1258-66.
1995: A Tchelet; N R Staten; D P Creely; G G Krivi; Arieh Gertler
Extracellular domain of prolactin receptor from bovine mammary gland: expression in Escherichia coli, purification and characterization of its interaction with lactogenic hormones.
The Journal of endocrinology 1995;144(3):393-403.
1994: S Horn; R Cohen; Arieh Gertler
Regulation of heat-shock protein (hsp70) gene expression by hGH and IL2 in rat Nb2 lymphoma cells.
Molecular and cellular endocrinology 1994;105(2):139-46.
1994: Arieh Gertler; C Bignon; N R Staten; E Sakal; A Tchelet; G G Krivi; Jean Djiane
Interaction of lactogenic hormones with the soluble extracellular domain of prolactin receptors.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):273-9.
1994: C Bignon; E Sakal; Lucette Belair; N Chapnik-Cohen; Jean Djiane; Arieh Gertler
Preparation of the extracellular domain of the rabbit prolactin receptor expressed in Escherichia coli and its interaction with lactogenic hormones.
The Journal of biological chemistry 1994;269(5):3318-24.
1994: A Tchelet; Arieh Gertler; E Sakal; Jean Djiane; T Vogel
Selective modification of human growth hormone by site-directed mutagenesis: implications for the diversity of biological actions.
Hormone research 1994;41 Suppl 2():103-12.
1993: E Sakal; A Tchelet; E Uchida; S Shimokawa; S Nishikawa; T Hayakawa; G G Krivi; Arieh Gertler
Site-directed mutagenesis of hGH at the 54-74 loop selectively modifies its lactogenic receptor-mediated biological activity.
Molecular and cellular endocrinology 1993;97(1-2):129-34.
1993: E Monsonego; O Halevy; Arieh Gertler; M Volokita; M Schickler; S Hurwitz; Mark Pines
Growth hormone receptors in avian epiphyseal growth-plate chondrocytes.
General and comparative endocrinology 1993;92(2):179-88.
1993: I Granot; O Halevy; A Tchelet; E Sakal; Arieh Gertler; T Vogel; S Hurwitz; Mark Pines
Effect of N-terminal modified analogs of growth hormone on collagen synthesis in avian skin fibroblasts.
Molecular and cellular endocrinology 1993;92(2):241-6.
1993: Arieh Gertler; B Petridou; G G Kriwi; Jean Djiane
Interaction of lactogenic hormones with purified recombinant extracellular domain of rabbit prolactin receptor expressed in insect cells.
FEBS letters 1993;319(3):277-81.
1993: I Peri; Arieh Gertler; I Bruckental; H Barash
The effect of manipulation in energy allowance during the rearing period of heifers on hormone concentrations and milk production in first lactation cows.
Journal of dairy science 1993;76(3):742-51.
1993: M Fine; E Sakal; D Vashdi; V Daniel; A Levanon; O Lipshitz; Arieh Gertler
Recombinant carp (Cyprinus carpio) growth hormone: expression, purification, and determination of biological activity in vitro and in vivo.
General and comparative endocrinology 1993;89(1):51-61.
1992: E Sakal; Arieh Gertler; L Aflalo; Rina Meidan
Characterization of insulin-like growth factor binding proteins secreted by cultured bovine theca and granulosa cells.
Molecular and cellular endocrinology 1992;90(1):39-46.
1992: D Vashdi; G Elberg; E Sakal; Arieh Gertler
Biological activity of bovine placental lactogen in 3T3-F442A preadipocytes is mediated through a somatogenic receptor.
FEBS letters 1992;305(2):101-4.
1992: Arieh Gertler; S D Hauser; E Sakal; D Vashdi; N Staten; J J Freeman; G G Krivi
Preparation, purification, and determination of the biological activities of 12 N terminus-truncated recombinant analogues of bovine placental lactogen.
The Journal of biological chemistry 1992;267(18):12655-9.
1992: I Peri; A Shamay; M F McGrath; Robert Collier; Arieh Gertler
Comparative mitogenic and galactopoietic effects of IGF-I, IGF-II and Des-3-IGF-I in bovine mammary gland in vitro.
Cell biology international reports 1992;16(4):359-68.
1992: Roberto Towns; J L Kostyo; T Vogel; E Sakal; A Tchelet; R Maher; Arieh Gertler
Evidence that the N-terminus of human growth hormone is involved in expression of its growth promoting, diabetogenic, and insulin-like activities.
Endocrinology 1992;130(3):1225-30.
1992: I Barash; Z Madar; Arieh Gertler
Short-term in vivo regulation of prolactin receptors in the liver, testes, kidneys, and mammary gland of rats.
Receptor 1992;2(1):39-44.
1992: Y Hertz; Y Shechter; Zecharia Madar; Arieh Gertler
Oral absorption of biologically active insulin in common carp (Cyprinus carpio L.).
Comparative biochemistry and physiology. A, Comparative physiology 1992;101(1):19-22.
1991: E Sakal; Arieh Gertler; Y Shechter
Biological activity of a fluorescein human growth hormone derivative prepared by specific covalent labeling of lysine-70.
Biochemistry 1991;30(36):8899-904.
1991: Y Shechter; E Sakal; R Cohen; N Cohen-Chapnik; Arieh Gertler
Hydroxyphenyl acetate derivatives inhibit protein tyrosine kinase activity and proliferation in Nb2 rat lymphoma cells and insulin-induced lipogenesis in rat adipocytes.
Molecular and cellular endocrinology 1991;80(1-3):183-92.
1991: S S Galosy; Arieh Gertler; G Elberg; D M Laird
Distinct placental lactogen and prolactin (lactogen) receptors in bovine endometrium.
Molecular and cellular endocrinology 1991;78(3):229-36.
1991: M Waksman; A Shamay; Arieh Gertler
Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins.
Domestic animal endocrinology 1991;8(2):271-80.
1991: Y Hertz; A Tchelet; Zecharia Madar; Arieh Gertler
Absorption of bioactive human growth hormone after oral administration in the common carp (Cyprinus carpio) and its enhancement by deoxycholate.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 1991;161(2):159-63.
1990: G Elberg; P A Kelly; J Djiane; L Binder; Arieh Gertler
Mitogenic and binding properties of monoclonal antibodies to the prolactin receptor in Nb2 rat lymphoma cells. Selective enhancement by anti-mouse IgG.
The Journal of biological chemistry 1990;265(25):14770-6.
1990: L Binder; Arieh Gertler; G Elberg; R Guy; T Vogel
Site-directed mutations of human growth hormone that selectively modify its lactogenic activity and binding properties.
Molecular endocrinology (Baltimore, Md.) 1990;4(7):1060-8.
1990: A Shamay; M Pines; M Waksman; Arieh Gertler
Proliferation of bovine undifferentiated mammary epithelial cells in vitro is modulated by G-proteins.
Molecular and cellular endocrinology 1990;69(2-3):217-26.
1989: C J Strasburger; L Binder; G Elberg; N Cohen-Chapnik; F Kohen; Arieh Gertler
Indication of different lactogen and somatogen binding sites in the human growth hormone molecule as probed with monoclonal antibodies.
Molecular and cellular endocrinology 1989;67(1):55-62.
1989: L Binder; T Vogel; D Hadary; G Elberg; Arieh Gertler
Chimeric bovine-human growth hormone prepared by recombinant DNA technology: binding properties and biological activity.
Molecular endocrinology (Baltimore, Md.) 1989;3(6):923-30.
1989: A Shamay; N Cohen; Z Madar; I Levin; Arieh Gertler
Effect of prolactin on casein and fat synthesis and casein secretion in explants of bovine mammary tissue pretreated in athymic nude mice.
Journal of dairy science 1989;72(5):1169-74.
1989: G Elberg; A Ashkenazi; Arieh Gertler
Solubilization and characterization of lactogenic hormone receptor from kidney of lactating cow.
Molecular and cellular endocrinology 1989;61(1):77-85.
1988: A Shamay; N Cohen; M Niwa; Arieh Gertler
Effect of insulin-like growth factor I on deoxyribonucleic acid synthesis and galactopoiesis in bovine undifferentiated and lactating mammary tissue in vitro.
Endocrinology 1988;123(2):804-9.
1988: Mark Pines; A Ashkenazi; N Cohen-Chapnik; L Binder; Arieh Gertler
Inhibition of the proliferation of Nb2 cells by femtomolar concentrations of cholera toxin and partial reversal of the effect by 12-O-tetradecanoyl-phorbol-13-acetate.
Journal of cellular biochemistry 1988;37(1):119-29.
1987: A Ashkenazi; T Vogel; I Barash; D Hadari; A Levanon; M Gorecki; Arieh Gertler
Comparative study of in vitro and in vivo modulation of lactogenic and somatotropic receptors by native human growth hormone and its modified analog prepared by recombinant deoxyribonucleic acid technology.
Endocrinology 1987;121(1):414-9.
1987: A Ashkenazi; M Pines; Arieh Gertler
Down-regulation of lactogenic hormone receptors in Nb2 lymphoma cells by cholera toxin.
Biochemistry international 1987;14(6):1065-72.
1987: R Cohen; A Ashkenazi; G Elberg; Arieh Gertler
A comparative study of lactogenic hormone binding sites in the adrenal gland, ovary and kidney of the lactating cow.
Journal of receptor research 1987;7(6):921-36.
1986: I Barash; Z Madar; Arieh Gertler
Short-term regulation of prolactin receptors in the liver, mammary gland and kidney of pregnant and lactating rats infused with ovine prolactin or human growth hormone.
Molecular and cellular endocrinology 1986;46(3):235-44.
1986: Arieh Gertler; A Shamay; N Cohen; A Ashkenazi; H G Friesen; A Levanon; M Gorecki; H Aviv; D Hadary; T Vogel
Inhibition of lactogenic activities of ovine prolactin and human growth hormone (hGH) by a novel form of a modified recombinant hGH.
Endocrinology 1986;118(2):720-6.
1983: I Barash; Z Madar; Arieh Gertler
Down-regulation of prolactin receptors in the liver, mammary gland and kidney of female virgin rat, infused with ovine prolactin or human growth hormone.
Biochemical and biophysical research communications 1983;116(2):644-50.