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Philippe Gervois

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Nicolas Renault; Pierre Desreumaux; Jamal El Bakali; Amaury Farce; Christophe Furman; Philippe Gervois; Xavier Laurent; Roxane Mansouri; Régis Millet; Philippe CHAVATTE
Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.
Philippe Gervois; Roxane M Mansouri
PPARα as a therapeutic target in inflammation-associated diseases.
Roxane M Mansouri; Eric Baugé; Philippe Gervois; Jamila Fruchart-Najib; Catherine Fiévet; Bart Staels; Jean-Charles Fruchart
Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.

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All Publications

2013: Nicolas Renault; Pierre Desreumaux; Jamal El Bakali; Amaury Farce; Christophe Furman; Philippe Gervois; Xavier Laurent; Roxane Mansouri; Régis Millet; Philippe CHAVATTE
Virtual screening of CB(2) receptor agonists from bayesian network and high-throughput docking: structural insights into agonist-modulated GPCR features.
Chemical biology & drug design 2013;81(4):442-54.
2012: Philippe Gervois; Roxane M Mansouri
PPARα as a therapeutic target in inflammation-associated diseases.
Expert opinion on therapeutic targets 2012;16(11):1113-25.
2008: Roxane M Mansouri; Eric Baugé; Philippe Gervois; Jamila Fruchart-Najib; Catherine Fiévet; Bart Staels; Jean-Charles Fruchart
Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.
Circulation research 2008;103(5):450-3.
2008: Roxane M Mansouri; Eric Baugé; Bart Staels; Philippe Gervois
Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response.
Endocrinology 2008;149(6):3215-23.
2007: Coralie Fontaine; Elena Rigamonti; Atsushi Nohara; Philippe Gervois; Elisabeth Teissier; Jean-Charles Fruchart; Bart Staels; Giulia Chinetti-Gbaguidi
Liver X receptor activation potentiates the lipopolysaccharide response in human macrophages.
Circulation research 2007;101(1):40-9.
2007: Philippe Gervois; Jean-Charles Fruchart; Bart Staels
Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors.
Nature clinical practice. Endocrinology & metabolism 2007;3(2):145-56.
2006: Alberto Zambon; Philippe Gervois; Paolo Pauletto; Jean-Charles Fruchart; Bart Staels
Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):977-86.
2005: Florence Gizard; Romain Robillard; Philippe Gervois; Anne Faucompré; Françoise Révillion; Jean-Philippe Peyrat; W Dean Hum; Bart Staels
Progesterone inhibits human breast cancer cell growth through transcriptional upregulation of the cyclin-dependent kinase inhibitor p27Kip1 gene.
FEBS letters 2005;579(25):5535-41.
2005: Caroline Chauvet; Brigitte Bois-Joyeux; Coralie Fontaine; Philippe Gervois; Marguerite-Anne Bernard; Bart Staels; Jean-Louis Danan
The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2517-26.
2004: Philippe Gervois; Robert Kleemann; Antoine Pilon; Frédéric Percevault; Wolfgang Koenig; Bart Staels; Teake Kooistra
Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate.
The Journal of biological chemistry 2004;279(16):16154-60.
2003: Coralie Fontaine; Guillaume Dubois; Yannick Duguay; Torben Helledie; Ngoc Vu-Dac; Philippe Gervois; Fabrice SONCIN; Susanne Mandrup; Jean-Charles Fruchart; Jamila Fruchart-Najib; Bart Staels
The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation.
The Journal of biological chemistry 2003;278(39):37672-80.
2003: Ngoc Vu-Dac; Philippe Gervois; Heidelinde Jakel; Maxime NOWAK; Eric Bauge; Hélène Dehondt; Bart Staels; Len A Pennacchio; Edward M Rubin; Jamila Fruchart-Najib; Jean-Charles Fruchart
Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.
The Journal of biological chemistry 2003;278(20):17982-5.
2003: Robert Kleemann; Philippe Gervois; Lars Verschuren; Bart Staels; Hans M G Princen; Teake Kooistra
Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation.
Blood 2003;101(2):545-51.
2003: Philippe Gervois; Jean-Charles Fruchart
[PPAR gamma: a major nuclear receptor in adipogenesis].
Médecine sciences : M/S 2003;19(1):20-2.
2001: Sabine M Post; H Duez; Philippe Gervois; Bart Staels; Folkert Kuipers; Hans M G Princen
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1840-5.
2001: Philippe Gervois; Ngoc Vu-Dac; Robert Kleemann; M Kockx; Guillaume Dubois; B Laine; Vladimir Kosykh; Jean-Charles Fruchart; Teake Kooistra; Bart Staels
Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta.
The Journal of biological chemistry 2001;276(36):33471-7.
2001: Eric Raspé; Hélène Duez; Philippe Gervois; Catherine Fiévet; Jean-Charles Fruchart; Sandrine Besnard; Jean Mariani; Alain Tedgui; Bart Staels
Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha.
The Journal of biological chemistry 2001;276(4):2865-71.
2000: Michèle Guerre-Millo; Philippe Gervois; Eric Raspé; Lise Madsen; Philippe Poulain; B Derudas; J M Herbert; Deborah Winegar; T M Willson; Jean-Charles Fruchart; R K Berge; Bart Staels
Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity.
The Journal of biological chemistry 2000;275(22):16638-42.
2000: Philippe Gervois; Inés Pineda Torra; J C Fruchart; B Staels
Regulation of lipid and lipoprotein metabolism by PPAR activators.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2000;38(1):3-11.
1999: Philippe Gervois; Inés Pineda Torra; Giulia Chinetti; T Grötzinger; Guillaume Dubois; Jean-Charles Fruchart; Jamila Fruchart-Najib; E Leitersdorf; Bart Staels
A truncated human peroxisome proliferator-activated receptor alpha splice variant with dominant negative activity.
Molecular endocrinology (Baltimore, Md.) 1999;13(9):1535-49.
1999: M Kockx; Philippe Gervois; Philippe Poulain; B Derudas; J M Peters; Frank J Gonzalez; Hans M G Princen; Teake Kooistra; Bart Staels
Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha.
Blood 1999;93(9):2991-8.
1999: Philippe Gervois; S Chopin-Delannoy; A Fadel; Guillaume Dubois; Vladimir Kosykh; Jean-Charles Fruchart; J Najïb; Vincent Laudet; Bart Staels
Fibrates increase human REV-ERBalpha expression in liver via a novel peroxisome proliferator-activated receptor response element.
Molecular endocrinology (Baltimore, Md.) 1999;13(3):400-9.
1998: Ngoc Vu-Dac; S Chopin-Delannoy; Philippe Gervois; Edith Bonnelye; Geneviève Martin; Jean-Charles Fruchart; Vincent Laudet; Bart Staels
The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates.
The Journal of biological chemistry 1998;273(40):25713-20.
1998: Ngoc Vu-Dac; Philippe Gervois; Inés Pineda Torra; Jean-Charles Fruchart; Vladimir Kosykh; Teake Kooistra; H M Princen; Jean Dallongeville; Bart Staels
Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids.
The Journal of clinical investigation 1998;102(3):625-32.
1997: Ngoc Vu-Dac; Philippe Gervois; T Grötzinger; P De Vos; K Schoonjans; Jean-Charles Fruchart; J Auwerx; Jean Mariani; Alain Tedgui; Bart Staels
Transcriptional regulation of apolipoprotein A-I gene expression by the nuclear receptor RORalpha.
The Journal of biological chemistry 1997;272(36):22401-4.