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William Gerwick

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Living Beings

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Papua New Guinea

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Marine Biology

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TOP 3
William H Gerwick; Amanda M Fenner
Drug discovery from marine microbes.
Niclas Engene; William H Gerwick; Sarath P Gunasekera; Valerie J Paul
Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria.
Pedro Leão; Vitor Ramos; William H Gerwick; Patrício B Gonçalves; Olga M Lage; Flávia Viana; Vitor Vasconcelos
Chemoecological screening reveals high bioactivity in diverse culturable portuguese marine cyanobacteria.

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All Publications

2013: William H Gerwick; Amanda M Fenner
Drug discovery from marine microbes.
Microbial ecology 2013;65(4):800-6.
2013: Niclas Engene; William H Gerwick; Sarath P Gunasekera; Valerie J Paul
Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria.
Applied and environmental microbiology 2013;79(6):1882-8.
2013: Pedro Leão; Vitor Ramos; William H Gerwick; Patrício B Gonçalves; Olga M Lage; Flávia Viana; Vitor Vasconcelos
Chemoecological screening reveals high bioactivity in diverse culturable portuguese marine cyanobacteria.
Marine drugs 2013;11(4):1316-35.
2012: Jennifer Gehret McCarthy; David H Sherman; Peter Wipf; Eli B Eisman; Lena Gerwick; William H Gerwick; Sarang Kulkarni; Janet L Smith
Structural basis of functional group activation by sulfotransferases in complex metabolic pathways.
ACS chemical biology 2012;7(12):1994-2003.
2012: Eun Ji Kim; Jong Hyun Lee; Je Won Park; Alban R Pereira; David H Sherman; Young Ji Yoo; Yeon Hee Ban; Hyukjae Choi; William H Gerwick; Eunji Kim; Yeo Joon Yoon
Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product.
Organic letters 2012;14(23):5824-7.
2012: Joju George; William H Gerwick; Daniel G Baden; Thomas F Murray
Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(48):19840-5.
2012: Paul D Boudreau; Tara Byrum; Pieter dorrestein; Wei-Ting Liu; William H Gerwick
Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium.
Journal of natural products 2012;75(9):1560-70.
2012: David J Gonzalez; Paul R Jensen; Chih-Chuang Liaw; Wei-Ting Liu; István Molnár; Victor Nizet; Paul Straight; Yuquan Xu; Yu-Liang Yang; Liangcheng Du; Tram Duong; Anna Edlund; Eduardo Esquenazi; Michael Fischbach; William H Gerwick; Pieter dorrestein
Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes.
Journal of proteomics 2012;75(16):5069-76.
2012: Marcy J Balunas; Niclas Engene; Lena Gerwick; Manuel F Grosso; Dennis E Kyle; Kerry L McPhail; Laura M Pineda; Carmenza Spadafora; Kevin Tidgewell; Francisco A Villa; William H Gerwick
Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins.
Organic letters 2012;14(15):3878-81.
2012: Hyukjae Choi; Lena Gerwick; Tara Byrum; Samantha J Mascuch; Linda B Preskitt; David C Rowley; Jennifer E Smith; Margaret E Teasdale; Francisco A Villa; William H Gerwick
Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships.
Chemistry & biology 2012;19(5):589-98.
2012: Joshawna K Nunnery; Alban R Pereira; Sairam V Jabba; Teatulohi Matainaho; Thomas F Murray; Tara Byrum; Zhengyu Cao; Niclas Engene; William H Gerwick
Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.
The Journal of organic chemistry 2012;77(9):4198-208.
2012: Niclas Engene; Tara Byrum; Hyukjae Choi; Mark H Ellisman; Jiří Komárek; Erin C Rottacker; Jan Kaštovský; William H Gerwick
Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites.
International journal of systematic and evolutionary microbiology 2012;62(Pt 5):1171-8.
2012: Alban R Pereira; Frederick A Valeriote; Michael K Gilson; Andrew J Kale; Bradley S Moore; Tara Byrum; Hosana M Debonsi; Andrew T Fenley; William H Gerwick
The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium.
Chembiochem : a European journal of chemical biology 2012;13(6):810-7.
2012: Adam C Jones; Bradley S Moore; Sabine Ottilie; Daniel J Edwards; Alessandra S Eustáquio; Lena Gerwick; William H Gerwick
Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A.
The FEBS journal 2012;279(7):1243-51.
2012: Pedro N Leão; Agostinho Antunes; Niclas Engene; William H Gerwick; Vitor Vasconcelos
The chemical ecology of cyanobacteria.
Natural product reports 2012;29(3):372-91.
2012: Sergio Martínez-Luis; Carmenza Spadafora; Elizabeth Arnold; Lilia Cherigo; William H Gerwick; Luis Cubilla-Rios
Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544.
Natural product communications 2012;7(2):165-8.
2012: Jennifer J Gehret; Lena Gerwick; William H Gerwick; Liangcai Gu; David H Sherman; William Clay Brown; Todd W Geders; Janet L Smith
Structure and activity of DmmA, a marine haloalkane dehalogenase.
Protein science : a publication of the Protein Society 2012;21(2):239-48.
2012: William H Gerwick; Bradley S Moore
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.
Chemistry & biology 2012;19(1):85-98.
2012: Karla L Malloy; Teatulohi Matainaho; Thomas F Murray; Carmenza Spadafora; Takashi L Suyama; Zhengyu Cao; Hosana Debonsi; Niclas Engene; William H Gerwick
Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.
Journal of natural products 2012;75(1):60-6.
2012: Pep Charusanti; Nicole L Fong; William H Gerwick; Howard J Li; Harish Nagarajan; Alban R Pereira; Yongxuan Su; Elisa A Abate; Bernhard O Palsson
Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction.
PloS one 2012;7(3):e33727.
2011: Eduardo Esquenazi; William H Gerwick; Tasneem Bahrainwala; Michael Daly; Pieter dorrestein
Ion mobility mass spectrometry enables the efficient detection and identification of halogenated natural products from cyanobacteria with minimal sample preparation.
Bioorganic & medicinal chemistry 2011;19(22):6639-44.
2011: Carla S Jones; Pieter dorrestein; Eduardo Esquenazi; William H Gerwick
Probing the in vivo biosynthesis of scytonemin, a cyanobacterial ultraviolet radiation sunscreen, through small scale stable isotope incubation studies and MALDI-TOF mass spectrometry.
Bioorganic & medicinal chemistry 2011;19(22):6620-7.
2011: Takashi L Suyama; William H Gerwick; Kerry L McPhail
Survey of marine natural product structure revisions: a synergy of spectroscopy and chemical synthesis.
Bioorganic & medicinal chemistry 2011;19(22):6675-701.
2011: Marcelino Gutiérrez; Alessia Ligresti; Alban R Pereira; Hosana M Debonsi; Vincenzo Di Marzo; William H Gerwick
Cannabinomimetic lipid from a marine cyanobacterium.
Journal of natural products 2011;74(10):2313-7.
2011: Bingnan Han; Claudia S Maier; Kerry L McPhail; Douglas E Goeger; Harald Gross; William H Gerwick
Wewakamide A and guineamide G, cyclic depsipeptides from the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula.
Journal of microbiology and biotechnology 2011;21(9):930-6.
2011: Niclas Engene; Eduardo Esquenazi; Lena Gerwick; Tara Byrum; Zhengyu Cao; Hyukjae Choi; Pieter dorrestein; Thomas F Murray; Francisco A Villa; William H Gerwick
Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera.
Journal of natural products 2011;74(8):1737-43.
2011: Sergio Martínez-Luis; Carmenza Spadafora; Elizabeth Arnold; Lilia Cherigo; William H Gerwick; Sarah Higginbotham; Alicia Ibañez; Luis Cubilla-Rios
Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi.
International microbiology : the official journal of the Spanish Society for Microbiology 2011;14(2):95-102.
2011: Eufemio Moreno; Carmenza Spadafora; Titto Varughese; A Elizabeth Arnold; Phyllis D Coley; William H Gerwick; Thomas A Kursar; Luis Cubilla-Rios
Chemical constituents of the new endophytic fungus Mycosphaerella sp. nov. and their anti-parasitic activity.
Natural product communications 2011;6(6):835-40.
2011: Daniel W Udwary; Erin A Gontang; Adam C Jones; Carla S Jones; Andrew W Schultz; Jaclyn M Winter; Jane Y Yang; Nicholas Beauchemin; Todd L Capson; Benjamin R Clark; Eduardo Esquenazi; Alessandra S Eustáquio; Kelle Freel; Lena Gerwick; William H Gerwick; David Gonzalez; Wei-Ting Liu; Karla L Malloy; Katherine N Maloney; Markus Nett; Joshawna K Nunnery; Kevin Penn; Alejandra Prieto-Davo; Thomas L Simmons; Sara Weitz; Micheal C Wilson; Louis S Tisa; Pieter dorrestein; Bradley S Moore
Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses.
Applied and environmental microbiology 2011;77(11):3617-25.
2011: Niclas Engene; Hyukjae Choi; Eduardo Esquenazi; Erin C Rottacker; Mark H Ellisman; Pieter dorrestein; William H Gerwick
Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya.
Environmental microbiology 2011;13(6):1601-10.
2011: Emily Mevers; Wei-Ting Liu; Niclas Engene; Hosein Mohimani; Tara Byrum; Pavel A Pevzner; Pieter dorrestein; Carmenza Spadafora; William H Gerwick
Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera.
Journal of natural products 2011;74(5):928-36.
2011: Adam C Jones; Emily A Monroe; Sheila Podell; Wolfgang R Hess; Sven Klages; Eduardo Esquenazi; Sherry Niessen; Heather Hoover; Michael Rothmann; Roger S Lasken; John R Yates; Richard Reinhardt; Michael Kube; Michael D Burkart; Eric E Allen; Pieter dorrestein; William H Gerwick; Lena Gerwick
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(21):8815-20.
2011: Jennifer J Gehret; Liangcai Gu; William H Gerwick; Peter Wipf; David H Sherman; Janet L Smith
Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase.
The Journal of biological chemistry 2011;286(16):14445-54.
2011: Eduardo Esquenazi; Adam C Jones; Tara Byrum; Pieter dorrestein; William H Gerwick
Temporal dynamics of natural product biosynthesis in marine cyanobacteria.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(13):5226-31.
2011: Adam C Jones; Emily A Monroe; William H Gerwick
Elegant metabolite biosynthesis.
Chemistry & biology 2011;18(3):281-3.
2011: Liangcai Gu; Eli B Eisman; Somnath Dutta; Titus M Franzmann; Stefan Walter; William H Gerwick; georgios skiniotis; David H Sherman
Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect.
Angewandte Chemie (International ed. in English) 2011;50(12):2795-8.
2011: Karla L Malloy; Francisco A Villa; Niclas Engene; Teatulohi Matainaho; Lena Gerwick; William H Gerwick
Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium.
Journal of natural products 2011;74(1):95-8.
2011: Rashel V Grindberg; Thomas Ishoey; Dumitru Brinza; Eduardo Esquenazi; R Cameron Coates; Wei-Ting Liu; Lena Gerwick; Pieter dorrestein; Pavel A Pevzner; Roger Lasken; William H Gerwick
Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage.
PloS one 2011;6(4):e18565.
2010: Joshawna K Nunnery; Emily Mevers; William H Gerwick
Biologically active secondary metabolites from marine cyanobacteria.
Current opinion in biotechnology 2010;21(6):787-93.
2010: Alban R Pereira; Zhengyu Cao; Niclas Engene; Irma E Soria-Mercado; Thomas F Murray; William H Gerwick
Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria.
Organic letters 2010;12(20):4490-3.
2010: Harald Gross; Kerry L McPhail; Douglas E Goeger; Frederick A Valeriote; William H Gerwick
Two cytotoxic stereoisomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula.
Phytochemistry 2010;71(14-15):1729-35.
2010: Hyukjae Choi; Alban R Pereira; Zhengyu Cao; Cynthia F Shuman; Niclas Engene; Tara Byrum; Teatulohi Matainaho; Thomas F Murray; Alfonso Mangoni; William H Gerwick
The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria.
Journal of natural products 2010;73(8):1411-21.
2010: Dheeraj Khare; Bo Wang; Liangcai Gu; Jamie Razelun; David H Sherman; William H Gerwick; Kristina Håkansson; Janet L Smith
Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14099-104.
2010: Kevin Tidgewell; Niclas Engene; Tara Byrum; Joseph Media; Takayuki Doi; Frederick A Valeriote; William H Gerwick
Evolved diversification of a modular natural product pathway: apratoxins F and G, two cytotoxic cyclic depsipeptides from a Palmyra collection of Lyngbya bouillonii.
Chembiochem : a European journal of chemical biology 2010;11(10):1458-66.
2010: Adam C Jones; Emily A Monroe; Eli B Eisman; Lena Gerwick; David H Sherman; William H Gerwick
The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria.
Natural product reports 2010;27(7):1048-65.
2010: Pedro N Leão; Alban R Pereira; Wei-Ting Liu; Julio Ng; Pavel A Pevzner; Pieter C Dorrestein; Gabriele M König; Vitor Vasconcelos; William H Gerwick
Synergistic allelochemicals from a freshwater cyanobacterium.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11183-8.
2010: Laura M Sanchez; Dioxelis Lopez; Brian A Vesely; Gina Della Togna; William H Gerwick; Dennis E Kyle; Roger G Linington
Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds.
Journal of medicinal chemistry 2010;53(10):4187-97.
2010: Masatoshi Taniguchi; Joshawna K Nunnery; Niclas Engene; Eduardo Esquenazi; Tara Byrum; Pieter dorrestein; William H Gerwick
Palmyramide A, a cyclic depsipeptide from a Palmyra Atoll collection of the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2010;73(3):393-8.
2010: D Karl Bedke; Grant M Shibuya; Alban R Pereira; William H Gerwick; Christopher D Vanderwal
A concise enantioselective synthesis of the chlorosulfolipid malhamensilipin A.
Journal of the American Chemical Society 2010;132(8):2542-3.
2010: Alban R Pereira; Christine F McCue; William H Gerwick
Cyanolide A, a glycosidic macrolide with potent Molluscicidal activity from the Papua New Guinea cyanobacterium Lyngbya bouillonii.
Journal of natural products 2010;73(2):217-20.
2010: Alban R Pereira; Tara Byrum; Grant M Shibuya; Christopher D Vanderwal; William H Gerwick
Structure revision and absolute configuration of malhamensilipin A from the freshwater chrysophyte Poterioochromonas malhamensis.
Journal of natural products 2010;73(2):279-83.
2010: Takashi L Suyama; Zhengyu Cao; Thomas F Murray; William H Gerwick
Ichthyotoxic brominated diphenyl ethers from a mixed assemblage of a red alga and cyanobacterium: structure clarification and biological properties.
Toxicon : official journal of the International Society on Toxinology 2010;55(2-3):204-10.
2010: David L Akey; Jamie R Razelun; Jason Tehranisa; David H Sherman; William H Gerwick; Janet L Smith
Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.
Structure (London, England : 1993) 2010;18(1):94-105.
2010: Zhengyu Cao; William H Gerwick; Thomas F Murray
Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 α subunits.
BMC neuroscience 2010;11():154.
2010: Marcy J Balunas; Roger G Linington; Kevin Tidgewell; Amanda M Fenner; Luis-David Ureña; Gina Della Togna; Dennis E Kyle; William H Gerwick
Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity.
Journal of natural products 2010;73(1):60-6.
2010: Minh U Huynh; Matthew C Elston; Nick M Hernandez; David B Ball; Shin-ichiro Kajiyama; Kazuhiro Irie; William H Gerwick; Daniel J Edwards
Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase.
Journal of natural products 2010;73(1):71-4.
2009: Eduardo Esquenazi; Yu-Liang Yang; Jeramie Watrous; William H Gerwick; Pieter dorrestein
Imaging mass spectrometry of natural products.
Natural product reports 2009;26(12):1521-34.
2009: Liangcai Gu; Bo Wang; Amol Kulkarni; Jennifer J Gehret; Kayla R Lloyd; Lena Gerwick; William H Gerwick; Peter Wipf; Kristina Håkansson; Janet L Smith; David H Sherman
Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.
Journal of the American Chemical Society 2009;131(44):16033-5.
2009: Irma E Soria-Mercado; Alban Pereira; Zhengyu Cao; Thomas F Murray; William H Gerwick
Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.
Organic letters 2009;11(20):4704-7.
2009: Alban Pereira; Zhengyu Cao; Thomas F Murray; William H Gerwick
Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria.
Chemistry & biology 2009;16(8):893-906.
2009: Marcelino Gutiérrez; Eric H Andrianasolo; Won Kyo Shin; Douglas E Goeger; Alexandre Yokochi; Jörg Schemies; Manfred Jung; Dennis Stanley France; Susan Cornell-Kennon; Eun Lee; William H Gerwick
Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula.
The Journal of organic chemistry 2009;74(15):5267-75.
2009: Julio Ng; Nuno Bandeira; Wei-Ting Liu; Majid Ghassemian; Thomas L Simmons; William H Gerwick; Roger Linington; Pieter dorrestein; Pavel A Pevzner
Dereplication and de novo sequencing of nonribosomal peptides.
Nature methods 2009;6(8):596-9.
2009: Carla Sorrels; Philip J Proteau; William H Gerwick
Organization, evolution, and expression analysis of the biosynthetic gene cluster for scytonemin, a cyanobacterial UV-absorbing pigment.
Applied and environmental microbiology 2009;75(14):4861-9.
2009: D Karl Bedke; Grant M Shibuya; Alban Pereira; William H Gerwick; Thomas H Haines; Christopher D Vanderwal
Relative stereochemistry determination and synthesis of the major chlorosulfolipid from Ochromonas danica.
Journal of the American Chemical Society 2009;131(22):7570-2.
2009: Liangcai Gu; Bo Wang; Amol Kulkarni; Todd W Geders; Rashel V Grindberg; Lena Gerwick; Kristina Håkansson; Peter Wipf; Janet L Smith; William H Gerwick; David H Sherman
Metamorphic enzyme assembly in polyketide diversification.
Nature 2009;459(7247):731-5.
2009: T Luke Simmons; Lisa M Nogle; Joseph Media; Frederick A Valeriote; Susan Mooberry; William H Gerwick
Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms.
Journal of natural products 2009;72(6):1011-6.
2009: Wei-Ting Liu; Julio Ng; Dario Meluzzi; Nuno Bandeira; Marcelino Gutierrez; Thomas L Simmons; Andrew W Schultz; Roger G Linington; Bradley S Moore; William H Gerwick; Pavel A Pevzner; Pieter dorrestein
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides.
Analytical chemistry 2009;81(11):4200-9.
2009: Eduardo Esquenazi; Pieter dorrestein; William H Gerwick
Probing marine natural product defenses with DESI-imaging mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7269-70.
2009: Adam C Jones; Liangcai Gu; Carla Sorrels; David H Sherman; William H Gerwick
New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria.
Current opinion in chemical biology 2009;13(2):216-23.
2009: Adam C Jones; Lena Gerwick; David Gonzalez; Pieter C Dorrestein; William H Gerwick
Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins.
BMC microbiology 2009;9():247.
2009: Roger G Linington; Benjamin R Clark; Erin E Trimble; Alejandro Almanza; Luis-David Ureña; Dennis E Kyle; William H Gerwick
Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.
Journal of natural products 2009;72(1):14-7.
2008: Sergio Martínez-Luis; Gina Della-Togna; Phyllis D Coley; Thomas A Kursar; William H Gerwick; Luis Cubilla-Rios
Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp.
Journal of natural products 2008;71(12):2011-4.
2008: Takashi L Suyama; William H Gerwick
Stereospecific total synthesis of somocystinamide A.
Organic letters 2008;10(20):4449-52.
2008: T Luke Simmons; Niclas Engene; Luis David Ureña; Luz I Romero; Eduardo Ortega-Barría; Lena Gerwick; William H Gerwick
Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis.
Journal of natural products 2008;71(9):1544-50.
2008: Benjamin R Clark; Niclas Engene; Margaret E Teasdale; David C Rowley; Teatulohi Matainaho; Frederick A Valeriote; William H Gerwick
Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum.
Journal of natural products 2008;71(9):1530-7.
2008: Zhengyu Cao; Joju George; William H Gerwick; Daniel G Baden; Jon D Rainier; Thomas F Murray
Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons.
The Journal of pharmacology and experimental therapeutics 2008;326(2):604-13.
2008: Eduardo Esquenazi; Cameron Coates; Luke Simmons; David Gonzalez; William H Gerwick; Pieter dorrestein
Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging.
Molecular bioSystems 2008;4(6):562-70.
2008: Marcelino Gutiérrez; Takashi L Suyama; Niclas Engene; Joshua S Wingerd; Teatulohi Matainaho; William H Gerwick
Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida.
Journal of natural products 2008;71(6):1099-103.
2008: Rebecca A Medina; Douglas E Goeger; Patrice Hills; Susan Mooberry; Nelson Huang; Luz I Romero; Eduardo Ortega-Barría; William H Gerwick; Kerry L McPhail
Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp.
Journal of the American Chemical Society 2008;130(20):6324-5.
2008: T Luke Simmons; R Cameron Coates; Benjamin R Clark; Niclas Engene; David Gonzalez; Eduardo Esquenazi; Pieter dorrestein; William H Gerwick
Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4587-94.
2008: Wolf Wrasidlo; Ainhoa Mielgo; Vicente A Torres; Simone Barbero; Konstantin Stoletov; Takashi L Suyama; Richard L Klemke; William H Gerwick; Dennis A Carson; Stupack Dwayne
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2313-8.
2008: Roger G Linington; Daniel J Edwards; Cynthia F Shuman; Kerry L McPhail; Teatulohi Matainaho; William H Gerwick
Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp.
Journal of natural products 2008;71(1):22-7.
2007: Todd W Geders; Liangcai Gu; Jonathan C Mowers; Haichuan Liu; William H Gerwick; Kristina Håkansson; David H Sherman; Janet L Smith
Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.
The Journal of biological chemistry 2007;282(49):35954-63.
2007: Aishwarya V Ramaswamy; Carla Sorrels; William H Gerwick
Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2007;70(12):1977-86.
2007: Olga Kourtchenko; Mats X Andersson; Mats Hamberg; Asa Brunnström; Cornelia Göbel; Kerry L McPhail; William H Gerwick; Ivo Feussner; Mats Ellerström
Oxo-phytodienoic acid-containing galactolipids in Arabidopsis: jasmonate signaling dependence.
Plant physiology 2007;145(4):1658-69.
2007: Liangcai Gu; Todd W Geders; Bo Wang; William H Gerwick; Kristina Håkansson; Janet L Smith; David H Sherman
GNAT-like strategy for polyketide chain initiation.
Science (New York, N.Y.) 2007;318(5852):970-4.
2007: Carlos Jiménez Romero; Daniel Torres-Mendoza; Luis David Ureña González; Eduardo Ortega-Barría; Kerry L McPhail; William H Gerwick; Luis Cubilla-Rios
Hydroxyalkenylresorcinols from Stylogyne turbacensis.
Journal of natural products 2007;70(8):1249-52.
2007: Kerry L McPhail; Jhonny Correa; Roger G Linington; Jose Gonzalez Santamaria; Eduardo Ortega-Barría; Todd L Capson; William H Gerwick
Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2007;70(6):984-8.
2007: Roger G Linington; Jose Gonzalez Santamaria; Luis-David Ureña; Luz I Romero; Eduardo Ortega-Barría; William H Gerwick
Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp.
Journal of natural products 2007;70(3):397-401.
2007: Harald Gross; Virginia O Stockwell; Marcella D Henkels; Brian Nowak-Thompson; Joyce E Loper; William H Gerwick
The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters.
Chemistry & biology 2007;14(1):53-63.
2006: Mats X Andersson; Mats Hamberg; Olga Kourtchenko; Asa Brunnström; Kerry L McPhail; William H Gerwick; Cornelia Göbel; Ivo Feussner; Mats Ellerström
Oxylipin profiling of the hypersensitive response in Arabidopsis thaliana. Formation of a novel oxo-phytodienoic acid-containing galactolipid, arabidopside E.
The Journal of biological chemistry 2006;281(42):31528-37.
2006: Takashi L Suyama; William H Gerwick
Practical total syntheses of epiquinamide enantiomers.
Organic letters 2006;8(20):4541-3.
2006: Liangcai Gu; Junyong Jia; Haichuan Liu; Kristina Håkansson; William H Gerwick; David H Sherman
Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair.
Journal of the American Chemical Society 2006;128(28):9014-5.
2006: Patricia M Flatt; Susan J O'Connell; Kerry L McPhail; Gloria Zeller; Christine L Willis; David H Sherman; William H Gerwick
Characterization of the initial enzymatic steps of barbamide biosynthesis.
Journal of natural products 2006;69(6):938-44.
2006: Daniel Torres-Mendoza; José González; Eduardo Ortega-Barría; Maria Verónica Heller; Todd L Capson; Kerry L McPhail; William H Gerwick; Luis Cubilla-Rios
Weakly antimalarial flavonol arabinofuranosides from Calycolpus warszewiczianus.
Journal of natural products 2006;69(5):826-8.
2006: Harald Gross; Douglas E Goeger; Patrice Hills; Susan Mooberry; David L Ballantine; Thomas F Murray; Frederick A Valeriote; William H Gerwick
Lophocladines, bioactive alkaloids from the red alga Lophocladia sp.
Journal of natural products 2006;69(4):640-4.
2006: Eric H Andrianasolo; Dennis Stanley France; Susan Cornell-Kennon; William H Gerwick
DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii.
Journal of natural products 2006;69(4):576-9.
2006: Bingnan Han; Harald Gross; Douglas E Goeger; Susan Mooberry; William H Gerwick
Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2006;69(4):572-5.
2006: Pieter dorrestein; Jonathan Blackhall; Paul D Straight; Michael A Fischbach; Sylvie Garneau-Tsodikova; Daniel J Edwards; Shaun McLaughlin; Myat Lin; William H Gerwick; Roberto Kolter; Christopher T Walsh; Neil L Kelleher
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry.
Biochemistry 2006;45(6):1537-46.
2006: Jhonny Correa; Carlos Hernán Ríos; Amparo del Rosario Castillo; Luz I Romero; Eduardo Ortega-Barría; Phyllis D Coley; Thomas A Kursar; Maria Verónica Heller; William H Gerwick; Luis Cubilla Rios
Minor alkaloids from Guatteria dumetorum with antileishmanial activity.
Planta medica 2006;72(3):270-2.
2005: Keith T LePage; Douglas E Goeger; F Yokokawa; T Asano; T Shioiri; William H Gerwick; Thomas F Murray
The neurotoxic lipopeptide kalkitoxin interacts with voltage-sensitive sodium channels in cerebellar granule neurons.
Toxicology letters 2005;158(2):133-9.
2005: Omar M M Sabry; Simeon Andrews; Kerry L McPhail; Douglas E Goeger; Alexandre F T Yokochi; Keith T LePage; Thomas F Murray; William H Gerwick
Neurotoxic meroditerpenoids from the tropical marine brown alga Stypopodium flabelliforme.
Journal of natural products 2005;68(7):1022-30.
2005: Bingnan Han; Douglas E Goeger; Claudia S Maier; William H Gerwick
The wewakpeptins, cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena.
The Journal of organic chemistry 2005;70(8):3133-9.
2005: Eric H Andrianasolo; Harald Gross; Douglas E Goeger; Mirjam Musafija-Girt; Kerry L McPhail; Rachel M Leal; Susan Mooberry; William H Gerwick
Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria.
Organic letters 2005;7(7):1375-8.
2005: T Luke Simmons; Eric H Andrianasolo; Kerry L McPhail; Patricia M Flatt; William H Gerwick
Marine natural products as anticancer drugs.
Molecular cancer therapeutics 2005;4(2):333-42.
2005: Keith T LePage; Robert W Dickey; William H Gerwick; Edward L Jester; Thomas F Murray
On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies.
Critical reviews in neurobiology 2005;17(1):27-50.
2004: Daniel J Edwards; William H Gerwick
Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase.
Journal of the American Chemical Society 2004;126(37):11432-3.
2004: Zunxue Chang; Namthip Sitachitta; James V Rossi; Mary Ann Roberts; Patricia M Flatt; Junyong Jia; David H Sherman; William H Gerwick
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2004;67(8):1356-67.
2004: Daniel J Edwards; Brian L Marquez; Lisa M Nogle; Kerry L McPhail; Douglas E Goeger; Mary Ann Roberts; William H Gerwick
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.
Chemistry & biology 2004;11(6):817-33.
2004: Kerry L McPhail; Dennis Stanley France; Susan Cornell-Kennon; William H Gerwick
Peyssonenynes a and B, novel enediyne oxylipins with DNA methyl transferase inhibitory activity from the red marine alga peyssonneliacaulifera.
Journal of natural products 2004;67(6):1010-3.
2004: WI Li; Brian L Marquez; T Okino; F Yokokawa; T Shioiri; William H Gerwick; Thomas F Murray
Characterization of the preferred stereochemistry for the neuropharmacologic actions of antillatoxin.
Journal of natural products 2004;67(4):559-68.
2004: Stefan Gafner; Chantal Bergeron; Megan M McCollom; Lorena M Cooper; Kerry L McPhail; William H Gerwick; Cindy K Angerhofer
Evaluation of the efficiency of three different solvent systems to extract triterpene saponins from roots of Panax quinquefolius using high-performance liquid chromatography.
Journal of agricultural and food chemistry 2004;52(6):1546-50.
2004: Satoshi Takamatsu; Dale G Nagle; William H Gerwick
Secondary metabolites from marine cyanobacteria and algae inhibit LFA-1/ICAM-1 mediated cell adhesion.
Planta medica 2004;70(2):127-31.
2003: Bingnan Han; Kerry L McPhail; Alessia Ligresti; Vincenzo Di Marzo; William H Gerwick
Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena.
Journal of natural products 2003;66(10):1364-8.
2003: Lik Tong Tan; Namthip Sitachitta; William H Gerwick
The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2003;66(6):764-71.
2003: Satoshi Takamatsu; Tyler W Hodges; Ira Rajbhandari; William H Gerwick; Mark T Hamann; Dale G Nagle
Marine natural products as novel antioxidant prototypes.
Journal of natural products 2003;66(5):605-8.
2003: Lisa M Nogle; William H Gerwick
Diverse secondary metabolites from a Puerto Rican collection of Lyngbyamajuscula.
Journal of natural products 2003;66(2):217-20.
2003: Lisa M Nogle; Brian L Marquez; William H Gerwick
Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula.
Organic letters 2003;5(1):3-6.
2003: Kerry L McPhail; William H Gerwick
Three new malyngamides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2003;66(1):132-5.
2002: R Thomas Williamson; Anna Boulanger; Alexandra Vulpanovici; Mary A Roberts; William H Gerwick
Structure and absolute stereochemistry of phormidolide, a new toxic metabolite from the marine cyanobacterium Phormidium sp.
The Journal of organic chemistry 2002;67(23):7927-36.
2002: Christopher S Stevenson; Elizabeth A Capper; Amy K Roshak; Brian Marquez; Chris Eichman; Jeffrey R Jackson; Michael Mattern; William H Gerwick; Robert S Jacobs; Lisa A Marshall
The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore.
The Journal of pharmacology and experimental therapeutics 2002;303(2):858-66.
2002: Zunxue Chang; Patricia M Flatt; William H Gerwick; Viet-Anh Nguyen; Christine L Willis; David H Sherman
The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit.
Gene 2002;296(1-2):235-47.
2002: Lik Tong Tan; Brian L Márquez; William H Gerwick
Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii.
Journal of natural products 2002;65(6):925-8.
2002: Brian L Marquez; Karl Shawn Watts; Alexandre F T Yokochi; Mary Ann Roberts; Pascal Verdier-Pinard; Jorge I Jimenez; Ernest Hamel; Paul J Scheuer; William H Gerwick
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.
Journal of natural products 2002;65(6):866-71.
2002: Wei Zheng; Mitchell L Wise; Annette Wyrick; James G Metz; Ling Yuan; William H Gerwick
Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA.
Archives of biochemistry and biophysics 2002;401(1):11-20.
2002: Lisa M Nogle; William H Gerwick
Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage.
Organic letters 2002;4(7):1095-8.
2002: Hye-Dong Yoo; Sharon O Ketchum; Dennis Stanley France; Kenneth W Bair; William H Gerwick
Vidalenolone, a novel phenolic metabolite from the tropical red alga Vidalia sp.
Journal of natural products 2002;65(1):51-3.
2002: Lisa M Nogle; William H Gerwick
Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula.
Journal of natural products 2002;65(1):21-4.
2001: Lisa M Nogle; T Okino; William H Gerwick
Antillatoxin B, a neurotoxic lipopeptide from the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2001;64(7):983-5.
2001: WI Li; Frederick W Berman; T Okino; F Yokokawa; T Shioiri; William H Gerwick; Thomas F Murray
Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7599-604.
2001: Lisa M Nogle; R Thomas Williamson; William H Gerwick
Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species.
Journal of natural products 2001;64(6):716-9.
2001: William H Gerwick; Lik Tong Tan; Namthip Sitachitta
Nitrogen-containing metabolites from marine cyanobacteria.
The Alkaloids. Chemistry and biology 2001;57():75-184.
2000: KE Milligan; Brian L Marquez; R Thomas Williamson; William H Gerwick
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2000;63(10):1440-3.
2000: KE Milligan; Brian L Márquez; R Thomas Williamson; M Davies-Coleman; William H Gerwick
Two new malyngamides from a Madagascan Lyngbya majuscula.
Journal of natural products 2000;63(7):965-8.
2000: Lik Tong Tan; T Okino; William H Gerwick
Hermitamides A and B, toxic malyngamide-type natural products from the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 2000;63(7):952-5.
2000: R Thomas Williamson; John R Carney; William H Gerwick
Application of the BIRD sandwich for the rapid and accurate determination of (1)H-(1)H NMR coupling constants in higher order spin systems.
Journal of natural products 2000;63(6):876-8.
2000: R Thomas Williamson; Eleanor L Chapin; A W Carr; J R Gilbert; Paul R Graupner; Paul Lewer; P McKamey; John R Carney; William H Gerwick
New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures.
Organic letters 2000;2(3):289-92.
2000: Namthip Sitachitta; R Thomas Williamson; William H Gerwick
Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species.
Journal of natural products 2000;63(2):197-200.
2000: Lik Tong Tan; R Thomas Williamson; William H Gerwick; K S Watts; K McGough; R Jacobs
cis,cis- and trans,trans-ceratospongamide, new bioactive cyclic heptapeptides from the Indonesian red alga Ceratodictyon spongiosum and symbiotic sponge Sigmadocia symbiotica.
The Journal of organic chemistry 2000;65(2):419-25.
2000: Z D Jiang; Sharon O Ketchum; William H Gerwick
5-Lipoxygenase-derived oxylipins from the red alga Rhodymenia pertusa.
Phytochemistry 2000;53(1):129-33.
1999: Frederick W Berman; William H Gerwick; Thomas F Murray
Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity.
Toxicon : official journal of the International Society on Toxinology 1999;37(11):1645-8.
1999: Pascal Verdier-Pinard; Namthip Sitachitta; J V Rossi; D L Sackett; William H Gerwick; Ernest Hamel
Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.
Archives of biochemistry and biophysics 1999;370(1):51-8.
1999: I P Singh; KE Milligan; William H Gerwick
Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 1999;62(9):1333-5.
1999: William H Gerwick; M A Roberts; A Vulpanovici; D L Ballantine
Biogenesis and biological function of marine algal oxylipins.
Advances in experimental medicine and biology 1999;447():211-8.
1998: Brian L Márquez; Pascal Verdier-Pinard; Ernest Hamel; William H Gerwick
Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula.
Phytochemistry 1998;49(8):2387-9.
1998: Tiziana Bisogno; Dominique Melck; Luciano De Petrocellis; Natalia Gretskaya; Vladimir V. Bezuglov; Namthip Sitachitta; William H Gerwick; Vincenzo Di Marzo
Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.
Biochemical and biophysical research communications 1998;248(3):515-22.
1998: Namthip Sitachitta; William H Gerwick
Grenadadiene and grenadamide, cyclopropyl-containing fatty acid metabolites from the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 1998;61(5):681-4.
1998: M A Graber; William H Gerwick
Kalkipyrone, a toxic gamma-pyrone from an assemblage of the marine cyanobacteria Lyngbya majuscula and Tolypothrix sp.
Journal of natural products 1998;61(5):677-80.
1998: G J Hooper; Jimmy Orjala; R C Schatzman; William H Gerwick
Carmabins A and B, new lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula.
Journal of natural products 1998;61(4):529-33.
1998: Pascal Verdier-Pinard; J Y Lai; Hye-Dong Yoo; J Yu; Brian L Marquez; D G Nagle; M Nambu; J D White; J R Falck; William H Gerwick; B W Day; Ernest Hamel
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.
Molecular pharmacology 1998;53(1):62-76.
1997: Jimmy Orjala; William H Gerwick
Two quinoline alkaloids from the Caribbean cyanobacterium Lyngbya majuscula.
Phytochemistry 1997;45(5):1087-90.
1997: Mitchell L Wise; J Rossi; William H Gerwick
Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina.
Biochemistry 1997;36(10):2985-92.
1997: Z D Jiang; William H Gerwick
Novel oxylipins from the temperate red alga Polyneura latissima: evidence for an arachidonate 9(S)-lipoxygenase.
Lipids 1997;32(3):231-5.
1997: K Soderstrom; Thomas F Murray; Hye-Dong Yoo; Sharon O Ketchum; KE Milligan; William H Gerwick; M J Ortega; J Salva
Discovery of novel cannabinoid receptor ligands from diverse marine organisms.
Advances in experimental medicine and biology 1997;433():73-7.
1997: William H Gerwick; Mitchell L Wise; K Soderstrom; Thomas F Murray
Biosynthesis and cannabinoid receptor affinity of the novel eicosanoid, conjugated triene anandamide.
Advances in experimental medicine and biology 1997;407():329-34.
1996: William H Gerwick
Epoxy allylic carbocations as conceptual intermediates in the biogenesis of diverse marine oxylipins.
Lipids 1996;31(12):1215-31.
1996: Jimmy Orjala; William H Gerwick
Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula.
Journal of natural products 1996;59(4):427-30.
1996: M L Wise; K Soderstrom; Thomas F Murray; William H Gerwick
Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid.
Experientia 1996;52(1):88-92.
1995: A V Blokhin; H D Yoo; R S Geralds; D G Nagle; William H Gerwick; E Hamel
Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues.
Molecular pharmacology 1995;48(3):523-31.
1995: M V Mikhailova; D L Bemis; M L Wise; William H Gerwick; J N Norris; Robert S Jacobs
Structure and biosynthesis of novel conjugated polyene fatty acids from the marine green alga Anadyomene stellata.
Lipids 1995;30(7):583-9.
1995: Jimmy Orjala; D Nagle; William H Gerwick
Malyngamide H, an ichthyotoxic amide possessing a new carbon skeleton from the Caribbean cyanobacterium Lyngbya majuscula.
Journal of natural products 1995;58(5):764-8.
1995: J S Todd; William H Gerwick
Isolation of a cyclic carbonate, a gamma-butyrolactone, and a new indole derivative from the marine cyanobacterium Lyngbya majuscula.
Journal of natural products 1995;58(4):586-9.
1994: M L Wise; M Hamberg; William H Gerwick
Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina.
Biochemistry 1994;33(51):15223-32.
1994: Philip J Proteau; J V Rossi; William H Gerwick
Absolute stereochemistry of neohalicholactone from the brown alga Laminaria sinclairii.
Journal of natural products 1994;57(12):1717-9.
1994: J L Chen; William H Gerwick; R Schatzman; M Laney
Isorawsonol and related IMP dehydrogenase inhibitors from the tropical green alga Avrainvillea rawsonii.
Journal of natural products 1994;57(7):947-52.
1994: J L Chen; Philip J Proteau; M A Roberts; William H Gerwick; D L Slate; R H Lee
Structure of malhamensilipin A, an inhibitor of protein tyrosine kinase, from the cultured chrysophyte Poterioochromonas malhamensis.
Journal of natural products 1994;57(4):524-7.
1994: William H Gerwick
Structure and biosynthesis of marine algal oxylipins.
Biochimica et biophysica acta 1994;1211(3):243-55.
1994: J S Todd; Philip J Proteau; William H Gerwick
The absolute configuration of ecklonialactones A, B, and E, novel oxylipins from brown algae of the genera Ecklonia and Egregia.
Journal of natural products 1994;57(1):171-4.
1993: Philip J Proteau; William H Gerwick; F Garcia-Pichel; R Castenholz
The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria.
Experientia 1993;49(9):825-9.
1993: Philip J Proteau; William H Gerwick
Divinyl ethers and hydroxy fatty acids from three species of Laminaria (brown algae).
Lipids 1993;28(9):783-7.
1993: M W Bernart; G G Whatley; William H Gerwick
Unprecedented oxylipins from the marine green alga Acrosiphonia coalita.
Journal of natural products 1993;56(2):245-59.
1992: D G Nagle; W C McClatchey; William H Gerwick
New glycosphingolipids from the marine sponge Halichondria panicea.
Journal of natural products 1992;55(7):1013-7.
1991: Z D Jiang; William H Gerwick
An aldehyde-containing galactolipid from the red alga Gracilariopsis lemaneiformis.
Lipids 1991;26(11):960-3.
1991: M F Moghaddam; William H Gerwick
Cell-free biosynthesis and source of hydroxyl groups in (12R,13S)-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid, a novel eicosanoid from the marine alga Gracilariopsis lemaneiformis.
Journal of natural products 1991;54(6):1619-24.
1991: Z D Jiang; William H Gerwick
Novel pyrroles from the Oregon red alga Gracilariopsis lemaneiformis.
Journal of natural products 1991;54(2):403-7.
1990: M F Moghaddam; William H Gerwick; D L Ballantine
Discovery of the mammalian insulin release modulator, hepoxilin B3, from the tropical red algae Platysiphonia miniata and Cottoniella filamentosa.
The Journal of biological chemistry 1990;265(11):6126-30.
1989: M L Solem; Z D Jiang; William H Gerwick
Three new and bioactive icosanoids from the temperate red marine alga Farlowia mollis.
Lipids 1989;24(4):256-60.
1989: William H Gerwick
6-Desmethoxyhormothamnione, a new cytotoxic styrylchromone from the marine cryptophyte Chrysophaeum taylori.
Journal of natural products 1989;52(2):252-6.
1989: William H Gerwick; C Mrozek; M F Moghaddam; S K Agarwal
Novel cytotoxic peptides from the tropical marine cyanobacterium Hormothamnion enteromorphoides. 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material.
Experientia 1989;45(2):115-21.
1989: M F Moghaddam; William H Gerwick; D L Ballantine
Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata.
Prostaglandins 1989;37(2):303-8.
1988: D J Stennett; William H Gerwick; P K Egging; J M Christensen
Precipitate analysis from an indwelling total parenteral nutrition catheter.
JPEN. Journal of parenteral and enteral nutrition 1988;12(1):88-92.