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Andreas Gescher

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Glen R B Irving; Donald J L Jones; Ines Kralj-Hans; Andrew S Miller; Stewart Sale; Edwina N Scott; Wendy S Atkin; David P Berry; Robert G Britton; Karen Brown; Susan K Clark; Andreas J Gescher; David Hemingway; Lynne M Howells; William P Steward
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.
Shaban E A Saad; William P Steward; Robert G Britton; Karen Brown; Andreas J Gescher; Emma Horner-Glister; Donald J L Jones; Leonie M Norris; Ketan R Patel; Stewart Sale
Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.
Andreas J Gescher
Dose escalation and pharmacokinetic study of nanoparticle curcumin… by Kanai et al., CCP 69:65-70, 2012.

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2013: Glen R B Irving; Donald J L Jones; Ines Kralj-Hans; Andrew S Miller; Stewart Sale; Edwina N Scott; Wendy S Atkin; David P Berry; Robert G Britton; Karen Brown; Susan K Clark; Andreas J Gescher; David Hemingway; Lynne M Howells; William P Steward
Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.
Cancer prevention research (Philadelphia, Pa.) 2013;6(2):119-28.
2012: Shaban E A Saad; William P Steward; Robert G Britton; Karen Brown; Andreas J Gescher; Emma Horner-Glister; Donald J L Jones; Leonie M Norris; Ketan R Patel; Stewart Sale
Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.
Biomedical chromatography : BMC 2012;26(12):1559-66.
2012: Andreas J Gescher
Dose escalation and pharmacokinetic study of nanoparticle curcumin… by Kanai et al., CCP 69:65-70, 2012.
Cancer chemotherapy and pharmacology 2012;70(3):487.
2012: Ankur Karmokar; Timothy H Marczylo; William P Steward; Hong Cai; Andreas J Gescher; Karen Brown
Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development.
Molecular nutrition & food research 2012;56(5):775-83.
2011: Lynne M Howells; E W Jacobson; William P Steward; B Hegarty; E Hoffmann; David P Berry; Karen Brown; P J Elliott; Andreas J Gescher
Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics.
Cancer prevention research (Philadelphia, Pa.) 2011;4(9):1419-25.
2011: Friederike Teichert; Swantje Winkler; William P Steward; Peter B Farmer; Andreas J Gescher; Hector C Keun; Rajinder Singh
Evaluation of urinary ribonucleoside profiling for clinical biomarker discovery using constant neutral loss scanning liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2011;25(14):2071-82.
2011: Hong Cai; Sarah C Thomasset; Giuseppe Garcea; Karen Brown; William P Steward; David P Berry; Andreas J Gescher
Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract.
Biomedical chromatography : BMC 2011;25(6):660-3.
2011: Melanie Esselen; Jessica Fritz; Melanie Hutter; Nicole Teller; Simone Baechler; Ute Boettler; Timothy H Marczylo; Andreas J Gescher; Doris Marko
Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.
Molecular nutrition & food research 2011;55 Suppl 1():S143-53.
2011: Hong Cai; Stewart Sale; Robert G Britton; Karen Brown; William P Steward; Andreas J Gescher
Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone).
Cancer chemotherapy and pharmacology 2011;67(2):255-63.
2011: Ketan R Patel; Edwina Scott; Victoria A Brown; Andreas J Gescher; William P Steward; Karen Brown
Clinical trials of resveratrol.
Annals of the New York Academy of Sciences 2011;1215():161-9.
2010: Victoria A Brown; Ketan R Patel; Maria Viskaduraki; James A Crowell; Marjorie Perloff; Tristan D Booth; Grygoriy Vasilinin; Ananda Sen; Anna Maria Schinas; Gianfranca Piccirilli; Karen Brown; William P Steward; Andreas J Gescher; Dean E Brenner
Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.
Cancer research 2010;70(22):9003-11.
2010: Ketan R Patel; Victoria A Brown; Donald J L Jones; Robert G Britton; David Hemingway; Andrew S Miller; Kevin P West; Tristan D Booth; Marjorie Perloff; James A Crowell; Dean E Brenner; William P Steward; Andreas J Gescher; Karen Brown
Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.
Cancer research 2010;70(19):7392-9.
2010: Friederike Teichert; Richard D Verschoyle; Peter Greaves; Donald J L Jones; Ian D Wilson; Peter B Farmer; William P Steward; Andreas J Gescher; Hector C Keun
Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer.
Molecular bioSystems 2010;6(10):1911-6.
2010: Lynne M Howells; Robert G Britton; Marco Mazzoletti; Peter Greaves; Massimo Broggini; Karen Brown; William P Steward; Andreas J Gescher; Stewart Sale
Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.
Cancer prevention research (Philadelphia, Pa.) 2010;3(8):929-39.
2010: Hong Cai; Timothy H Marczylo; Nicole Teller; Karen Brown; William P Steward; Doris Marko; Andreas J Gescher
Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase.
European journal of cancer (Oxford, England : 1990) 2010;46(4):811-7.
2009: Stewart Sale; Isabel L Fong; Carla de Giovanni; Lorena Landuzzi; Karen Brown; William P Steward; Andreas J Gescher
APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the Apc(Min) mouse model in vivo.
European journal of cancer (Oxford, England : 1990) 2009;45(16):2731-5.
2009: Timothy H Marczylo; Darren Cooke; Karen Brown; William P Steward; Andreas J Gescher
Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice.
Cancer chemotherapy and pharmacology 2009;64(6):1261-8.
2009: Hong Cai; Stewart Sale; Ralf Schmid; Robert G Britton; Karen Brown; William P Steward; Andreas J Gescher
Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy.
Cancer prevention research (Philadelphia, Pa.) 2009;2(8):743-50.
2009: Sarah Thomasset; David P Berry; Hong Cai; Kevin West; Timothy H Marczylo; Debbie Marsden; Karen Brown; Ashley Dennison; Giuseppe Garcea; Andrew Miller; David Hemingway; William P Steward; Andreas J Gescher
Pilot study of oral anthocyanins for colorectal cancer chemoprevention.
Cancer prevention research (Philadelphia, Pa.) 2009;2(7):625-33.
2009: Edwina N Scott; Andreas J Gescher; William P Steward; Karen Brown
Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials.
Cancer prevention research (Philadelphia, Pa.) 2009;2(6):525-30.
2009: Sarah Thomasset; Nicole Teller; Hong Cai; Doris Marko; David P Berry; William P Steward; Andreas J Gescher
Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?
Cancer chemotherapy and pharmacology 2009;64(1):201-11.
2009: Nicole Teller; Wilko Thiele; Timothy H Marczylo; Andreas J Gescher; Ute Boettler; Jonathan Sleeman; Doris Marko
Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes.
Journal of agricultural and food chemistry 2009;57(8):3094-101.
2009: Hong Cai; Karen Brown; William P Steward; Andreas J Gescher
Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection.
Biomedical chromatography : BMC 2009;23(4):335-9.
2009: Timothy H Marczylo; William P Steward; Andreas J Gescher
Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method.
Journal of agricultural and food chemistry 2009;57(3):797-803.
2008: Andreas J Gescher
Resveratrol from red grapes - pedestrian polyphenol or useful anticancer agent?
Planta medica 2008;74(13):1651-5.
2008: William P Steward; Andreas J Gescher
Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research.
Molecular nutrition & food research 2008;52(9):1005-9.
2008: Friederike Teichert; Richard D Verschoyle; Peter Greaves; Richard E Edwards; Orla Teahan; Donald J L Jones; Ian D Wilson; Peter B Farmer; William P Steward; Timothy W Gant; Andreas J Gescher; Hector C Keun
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
The Prostate 2008;68(10):1035-47.
2008: Richard D Verschoyle; Karen Brown; William P Steward; Andreas J Gescher
Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse.
Cancer chemotherapy and pharmacology 2008;62(2):369-72.
2008: Richard D Verschoyle; Peter Greaves; Ketan Patel; Debbie A Marsden; Karen Brown; William P Steward; Andreas J Gescher
Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.
European journal of cancer (Oxford, England : 1990) 2008;44(6):898-906.
2008: Sanjeev Pathak; Rajinder Singh; Richard D Verschoyle; Peter Greaves; Peter B Farmer; William P Steward; J Kilian Mellon; Andreas J Gescher; Ricky A Sharma
Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo.
Cancer letters 2008;261(1):74-83.
2007: Jane A Bond; Andreas J Gescher; Richard D Verschoyle; Nick Lemoine; Rachel J Errington; Marie Wiltshire; Paul J Smith; David Wynford-Thomas
Cytotoxic action of phorbol esters on human pancreatic cancer cells.
International journal of cancer. Journal international du cancer 2007;121(7):1445-54.
2007: Hong Cai; David J Boocock; William P Steward; Andreas J Gescher
Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties.
Cancer chemotherapy and pharmacology 2007;60(2):257-66.
2007: Timothy H Marczylo; Richard D Verschoyle; Darren N Cooke; Paolo Morazzoni; William P Steward; Andreas J Gescher
Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine.
Cancer chemotherapy and pharmacology 2007;60(2):171-7.
2007: David J Boocock; Guy E S Faust; Ketan R Patel; Anna M Schinas; Victoria A Brown; Murray P Ducharme; Tristan D Booth; James A Crowell; Marjorie Perloff; Andreas J Gescher; William P Steward; Dean E Brenner
Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1246-52.
2007: Siminder Kaur; Peter Greaves; Darren N Cooke; Richard Edwards; William P Steward; Andreas J Gescher; Timothy H Marczylo
Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts.
Journal of agricultural and food chemistry 2007;55(9):3378-85.
2007: Maurizio D'Incalci; William P Steward; Andreas J Gescher
Modulation of response to cancer chemotherapeutic agents by diet constituents: is the available evidence sufficiently robust for rational advice for patients?
Cancer treatment reviews 2007;33(3):223-9.
2007: Carmen S L Hoh; David J Boocock; Timothy H Marczylo; V A Brown; Hong Cai; William P Steward; David P Berry; Andreas J Gescher
Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites.
Journal of agricultural and food chemistry 2007;55(7):2532-5.
2007: J F Thorpe; S Jain; Timothy H Marczylo; Andreas J Gescher; William P Steward; J Kilian Mellon
A review of phase III clinical trials of prostate cancer chemoprevention.
Annals of the Royal College of Surgeons of England 2007;89(3):207-11.
2007: David J Boocock; Ketan R Patel; Guy E S Faust; Daniel Normolle; Timothy H Marczylo; James A Crowell; Dean E Brenner; Tristan D Booth; Andreas J Gescher; William P Steward
Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;848(2):182-7.
2007: Sarah C Thomasset; David P Berry; Giuseppe Garcea; Timothy H Marczylo; William P Steward; Andreas J Gescher
Dietary polyphenolic phytochemicals--promising cancer chemopreventive agents in humans? A review of their clinical properties.
International journal of cancer. Journal international du cancer 2007;120(3):451-8.
2007: Richard D Verschoyle; Peter Greaves; Hong Cai; Richard E Edwards; William P Steward; Andreas J Gescher
Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis.
British journal of cancer 2007;96(2):248-54.
2007: Richard D Verschoyle; William P Steward; Andreas J Gescher
Putative cancer chemopreventive agents of dietary origin-how safe are they?
Nutrition and cancer 2007;59(2):152-62.
2007: Ricky A Sharma; William P Steward; Andreas J Gescher
Pharmacokinetics and pharmacodynamics of curcumin.
Advances in experimental medicine and biology 2007;595():453-70.
2006: Mohammad Al-Fayez; Hong Cai; Richard G Tunstall; William P Steward; Andreas J Gescher
Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin.
Cancer chemotherapy and pharmacology 2006;58(6):816-25.
2006: Darren Cooke; Michael Schwarz; David J Boocock; Peter Winterhalter; William P Steward; Andreas J Gescher; Timothy H Marczylo
Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels.
International journal of cancer. Journal international du cancer 2006;119(9):2213-20.
2006: Stewart Sale; Richard G Tunstall; Ketan Chatrabhuj Ruparelia; PC Butler; Gerry A Potter; William P Steward; Andreas J Gescher
Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse.
Investigational new drugs 2006;24(6):459-64.
2006: Hong Cai; Delphine Raynaud; William P Steward; Andreas J Gescher
A simple HPLC method for the determination of apigenin in mouse tissues.
Biomedical chromatography : BMC 2006;20(10):1038-42.
2006: Darren N Cooke; Sarah C Thomasset; David J Boocock; Michael Schwarz; Peter Winterhalter; William P Steward; Andreas J Gescher; Timothy H Marczylo
Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine.
Journal of agricultural and food chemistry 2006;54(19):7009-13.
2006: Clarissa Gerhauser; Helmut Bartsch; James Crowell; Silvio De Flora; Maurizio D'Incalci; Christian Dittrich; Norbert Frank; Enrico Mihich; Christian Steffen; Giampaolo Tortora; Andreas J Gescher
Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005.
European journal of cancer (Oxford, England : 1990) 2006;42(10):1338-43.
2006: Giuseppe Garcea; Andreas J Gescher; William Steward; Ashley Dennison; David Berry
Oxidative stress in humans following the Pringle manoeuvre.
Hepatobiliary & pancreatic diseases international : HBPD INT 2006;5(2):210-4.
2006: Carmen Hoh; David J Boocock; Timothy H Marczylo; Rajinder Singh; David P Berry; Ashley R Dennison; David Hemingway; Andrew Miller; Kevin West; Stephanie A Euden; Giuseppe Garcea; Peter B Farmer; William P Steward; Andreas J Gescher
Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2944-50.
2006: Richard G Tunstall; Ricky A Sharma; Sarah Perkins; Stewart Sale; Raj Singh; Peter B Farmer; William P Steward; Andreas J Gescher
Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: modification by dietary curcumin and implications for clinical trials.
European journal of cancer (Oxford, England : 1990) 2006;42(3):415-21.
2006: Karen R Reed; Owen J Sansom; Anthony J Hayes; Andreas J Gescher; Jeffrey M Peters; Alan R Clarke
PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.
BMC cancer 2006;6():113.
2006: Richard D Verschoyle; Peter Greaves; Hong Cai; Arndt Borkhardt; Massimo Broggini; Maurizio D'Incalci; Edward S Riccio; Rupa Doppalapudi; Izet M Kapetanovic; William P Steward; Andreas J Gescher
Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone.
Cancer chemotherapy and pharmacology 2006;57(1):1-6.
2005: Donald J L Jones; Rebekah Jukes-Jones; Richard D Verschoyle; Peter B Farmer; Andreas J Gescher
A synthetic approach to the generation of quercetin sulfates and the detection of quercetin 3'-O-sulfate as a urinary metabolite in the rat.
Bioorganic & medicinal chemistry 2005;13(24):6727-31.
2005: Maurizio D'Incalci; William P Steward; Andreas J Gescher
Use of cancer chemopreventive phytochemicals as antineoplastic agents.
The lancet oncology 2005;6(11):899-904.
2005: Hong Cai; Mohammad Al-Fayez; Richard G Tunstall; Sharon L Platton; Peter Greaves; William P Steward; Andreas J Gescher
The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice.
Molecular cancer therapeutics 2005;4(9):1287-92.
2005: Darren Cooke; William P Steward; Andreas J Gescher; Timothy H Marczylo
Anthocyans from fruits and vegetables--does bright colour signal cancer chemopreventive activity?
European journal of cancer (Oxford, England : 1990) 2005;41(13):1931-40.
2005: Ricky A Sharma; Andreas J Gescher; William P Steward
Curcumin: the story so far.
European journal of cancer (Oxford, England : 1990) 2005;41(13):1955-68.
2005: Andreas J Gescher; William P Steward
Cancer chemoprevention--an update on a (still) novel and exciting field of oncology.
European journal of cancer (Oxford, England : 1990) 2005;41(13):1831-2.
2005: Hong Cai; William P Steward; Andreas J Gescher
Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection.
Biomedical chromatography : BMC 2005;19(7):518-22.
2005: Stewart Sale; Richard G Tunstall; Ketan Chatrabhuj Ruparelia; Gerry A Potter; William P Steward; Andreas J Gescher
Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells.
International journal of cancer. Journal international du cancer 2005;115(2):194-201.
2005: Giuseppe Garcea; David P Berry; Donald J L Jones; Raj Singh; Ashley R Dennison; Peter B Farmer; Ricky A Sharma; William P Steward; Andreas J Gescher
Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(1):120-5.
2005: Margaret M Manson; Peter B Farmer; Andreas J Gescher; William P Steward
Innovative agents in cancer prevention.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2005;166():257-75.
2005: S K Pathak; Ricky A Sharma; William P Steward; J Kilian Mellon; T R L Griffiths; Andreas J Gescher
Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies.
European journal of cancer (Oxford, England : 1990) 2005;41(1):61-70.
2004: Karen R Reed; Owen J Sansom; Anthony J Hayes; Andreas J Gescher; Douglas J Winton; Jeffrey M Peters; Alan R Clarke
PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine.
Oncogene 2004;23(55):8992-6.
2004: Andreas J Gescher
Polyphenolic phytochemicals versus non-steroidal anti-inflammatory drugs: which are better cancer chemopreventive agents?
Journal of chemotherapy (Florence, Italy) 2004;16 Suppl 4():3-6.
2004: Ricky A Sharma; Stephanie A Euden; Sharon L Platton; Darren N Cooke; Aisha Shafayat; Heather R Hewitt; Timothy H Marczylo; Bruno Morgan; David Hemingway; Simon M Plummer; Munir Pirmohamed; Andreas J Gescher; William P Steward
Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):6847-54.
2004: Sarah Donald; Richard D Verschoyle; Peter Greaves; Tina Colombo; Massimo Zucchetti; Cristiano Falcioni; Marco Zaffaroni; Maurizio D'Incalci; Margaret M Manson; José Jimeno; William P Steward; Andreas J Gescher
Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma.
International journal of cancer. Journal international du cancer 2004;111(6):961-7.
2004: Hong Cai; E Ann Hudson; P Mann; Richard D Verschoyle; Peter Greaves; Margaret M Manson; William P Steward; Andreas J Gescher
Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo.
British journal of cancer 2004;91(7):1364-71.
2004: Donald J L Jones; John H Lamb; Richard D Verschoyle; Lynne M Howells; Michael Butterworth; Chang Kee Lim; D Ferry; Peter B Farmer; Andreas J Gescher
Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity.
British journal of cancer 2004;91(6):1213-9.
2004: Mark J Anderton; Margaret M Manson; Richard D Verschoyle; Andreas J Gescher; John H Lamb; Peter B Farmer; William P Steward; Marion L Williams
Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(15):5233-41.
2004: Mark J Anderton; Margaret M Manson; Richard D Verschoyle; Andreas J Gescher; William P Steward; Marion L Williams; Donald E Mager
Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(6):632-8.
2004: Sarah Donald; Richard D Verschoyle; Peter Greaves; Samantha Orr; José Jimeno; Andreas J Gescher
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.
Cancer chemotherapy and pharmacology 2004;53(4):305-12.
2004: Giuseppe Garcea; Donald J L Jones; Raj Singh; Ashley R Dennison; Peter B Farmer; Ricky A Sharma; William P Steward; Andreas J Gescher; David P Berry
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration.
British journal of cancer 2004;90(5):1011-5.
2004: Stewart Sale; Richard D Verschoyle; David J Boocock; Donald J L Jones; N Wilsher; Ketan Chatrabhuj Ruparelia; Gerry A Potter; Peter B Farmer; William P Steward; Andreas J Gescher
Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene.
British journal of cancer 2004;90(3):736-44.
2003: Hong Cai; Richard D Verschoyle; William P Steward; Andreas J Gescher
Determination of the flavone tricin in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2003;17(7):435-9.
2003: Andreas J Gescher; William P Steward
Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(10):953-7.
2003: Sarah Donald; Richard D Verschoyle; Peter Greaves; Timothy W Gant; Tina Colombo; Marco Zaffaroni; Roberta Frapolli; Massimo Zucchetti; Maurizio D'Incalci; Daniela Meco; Riccardo Riccardi; Luis Lopez-Lazaro; José Jimeno; Andreas J Gescher
Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat.
Cancer research 2003;63(18):5902-8.
2003: Sarah Perkins; A R Clarke; William P Steward; Andreas J Gescher
Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin.
British journal of cancer 2003;88(9):1480-3.
2003: Mark J Anderton; Rebekah Jukes; John H Lamb; Margaret M Manson; Andreas J Gescher; William P Steward; Marion L Williams
Liquid chromatographic assay for the simultaneous determination of indole-3-carbinol and its acid condensation products in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;787(2):281-91.
2003: Karl J Hale; Mark Frigerio; Soraya Manaviazar; Marc G Hummersone; Ian J Fillingham; Igor Barsukov; Christian Damblon; Andreas J Gescher; Gordon Roberts
Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process.
Organic letters 2003;5(4):499-502.
2003: Andreas J Gescher; Ricky A Sharma; William P Steward
Cancer prevention and delay are as important as cure.
The lancet oncology 2003;4(2):72-3.
2003: E Ann Hudson; Lynne M Howells; Barbara Gallacher-Horley; Louise H Fox; Andreas J Gescher; Margaret M Manson
Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.
BMC cancer 2003;3():2.
2002: Hari L Ratan; William P Steward; Andreas J Gescher; J Kilian Mellon
Resveratrol--a prostate cancer chemopreventive agent?
Urologic oncology 2002;7(6):223-7.
2002: Sarah Donald; Richard D Verschoyle; Richard Edwards; David J Judah; Reginald Davies; Joan Riley; David Dinsdale; Luis Lopez-Lazaro; Andrew G Smith; Timothy W Gant; Peter Greaves; Andreas J Gescher
Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat.
Cancer research 2002;62(15):4256-62.
2002: Sarah Perkins; Richard D Verschoyle; Kirsti Hill; Ifat Parveen; Michael Threadgill; Ricky A Sharma; Marion L Williams; William P Steward; Andreas J Gescher
Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(6):535-40.
2002: Christopher R Ireson; Donald J L Jones; Samantha Orr; Michael W H Coughtrie; David J Boocock; Marion L Williams; Peter B Farmer; William P Steward; Andreas J Gescher
Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(1):105-11.
2001: Simon M Plummer; KA Hill; Michael F W Festing; William P Steward; Andreas J Gescher; Ricky A Sharma
Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(12):1295-9.
2001: JM Tullett; DD Rees; David E G Shuker; Andreas J Gescher
Lack of correlation between the observed stability and pharmacological properties of S-nitroso derivatives of glutathione and cysteine-related peptides.
Biochemical pharmacology 2001;62(9):1239-47.
2001: Ricky A Sharma; Andreas J Gescher; JP Plastaras; Chiara Leuratti; Rajinder Singh; Barbara Gallacher-Horley; E Offord; Lawrence J Marnett; William P Steward; S M Plummer
Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells.
Carcinogenesis 2001;22(9):1557-60.
2001: K Dampier; E Ann Hudson; Lynne M Howells; Margaret M Manson; Rosemary A Walker; Andreas J Gescher
Differences between human breast cell lines in susceptibility towards growth inhibition by genistein.
British journal of cancer 2001;85(4):618-24.
2001: Ricky A Sharma; H R McLelland; KA Hill; Christopher R Ireson; Stephanie A Euden; Margaret M Manson; Munir Pirmohamed; Lawrence J Marnett; Andreas J Gescher; William P Steward
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1894-900.
2001: Andreas J Gescher; Ricky A Sharma; William P Steward
Cancer chemoprevention by dietary constituents: a tale of failure and promise.
The lancet oncology 2001;2(6):371-9.
2001: Ricky A Sharma; Christopher R Ireson; Richard D Verschoyle; KA Hill; Marion L Williams; Chiara Leuratti; Margaret M Manson; Lawrence J Marnett; William P Steward; Andreas J Gescher
Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1452-8.
2001: Christopher R Ireson; Samantha Orr; Donald J L Jones; Richard D Verschoyle; Chang Kee Lim; JL Luo; Lynne M Howells; Simon M Plummer; Rebekah Jukes; M Williams; William P Steward; Andreas J Gescher
Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.
Cancer research 2001;61(3):1058-64.
2000: E Ann Hudson; P A Dinh; Tetsuo Kokubun; M S Simmonds; Andreas J Gescher
Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(11):1163-70.
2000: Stuart M Raleigh; Richard D Verschoyle; C Bowskill; U Pastorino; J N Staniforth; F Steele; David Dinsdale; P Carthew; Chang Kee Lim; J Silvester; Andreas J Gescher
Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol.
British journal of cancer 2000;83(7):935-40.
2000: Andreas J Gescher
Staurosporine analogues - pharmacological toys or useful antitumour agents?
Critical reviews in oncology/hematology 2000;34(2):127-35.
2000: Margaret M Manson; Andreas J Gescher; E Ann Hudson; Simon M Plummer; Matthew S Squires; Sally A Prigent
Blocking and suppressing mechanisms of chemoprevention by dietary constituents.
Toxicology letters 2000;112-113():499-505.
1999: K Sugiyama; T Akiyama; M Shimizu; Tatsuya Tamaoki; Carol Courage; Andreas J Gescher; Shiro Akinaga
Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine).
Cancer research 1999;59(17):4406-12.
1999: A Freund; C Rössig; Claudia Lanvers; Andreas J Gescher; B Hohenlöchter; Heribert Jürgens; Joachim Boos
All-trans-retinoic acid increases cytosine arabinoside cytotoxicity in HL-60 human leukemia cells in spite of decreased cellular ara-CTP accumulation.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(3):335-8.
1998: Andreas J Gescher
Analogs of staurosporine: potential anticancer drugs?
General pharmacology 1998;31(5):721-8.
1998: S T Harkin; Gerald M Cohen; Andreas J Gescher
Modulation of apoptosis in rat thymocytes by analogs of staurosporine: lack of direct association with inhibition of protein kinase C.
Molecular pharmacology 1998;54(4):663-70.
1998: C A Hall-Jackson; T Jones; N G Eccles; T P Dawson; Jane A Bond; Andreas J Gescher; David Wynford-Thomas
Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target.
British journal of cancer 1998;78(5):641-51.
1998: MH Schultze-Mosgau; I L Dale; Timothy W Gant; J K Chipman; D J Kerr; Andreas J Gescher
Regulation of c-fos transcription by chemopreventive isoflavonoids and lignans in MDA-MB-468 breast cancer cells.
European journal of cancer (Oxford, England : 1990) 1998;34(9):1425-31.
1998: Donald J L Jones; Chang Kee Lim; D R Ferry; Andreas J Gescher
Determination of quercetin in human plasma by HPLC with spectrophotometric or electrochemical detection.
Biomedical chromatography : BMC 1998;12(4):232-5.
1998: A Freund; Joachim Boos; S Harkin; MH Schultze-Mosgau; G Veerman; Godefridus J Peters; Andreas J Gescher
Augmentation of 1-beta-D-arabinofuranosylcytosine (Ara-C) cytotoxicity in leukaemia cells by co-administration with antisignalling drugs.
European journal of cancer (Oxford, England : 1990) 1998;34(6):895-901.
1998: Andreas J Gescher; U Pastorino; Simon M Plummer; Margaret M Manson
Suppression of tumour development by substances derived from the diet--mechanisms and clinical implications.
British journal of clinical pharmacology 1998;45(1):1-12.
1997: Carol Courage; S M Bradder; T Jones; MH Schultze-Mosgau; Andreas J Gescher
Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine.
International journal of cancer. Journal international du cancer 1997;73(5):763-8.
1997: T Jones; Carol Courage; A Hubbard; Andreas J Gescher
Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues.
Biochemical pharmacology 1997;53(10):1413-8.
1997: J Budworth; Timothy W Gant; Andreas J Gescher
Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells.
British journal of cancer 1997;75(9):1330-5.
1996: Carol Courage; R Snowden; Andreas J Gescher
Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells.
British journal of cancer 1996;74(8):1199-205.
1996: H J Cross; M Tilby; J K Chipman; David R Ferry; Andreas J Gescher
Effect of quercetin on the genotoxic potential of cisplatin.
International journal of cancer. Journal international du cancer 1996;66(3):404-8.
1996: J Budworth; Reginald Davies; J Malkhandi; Timothy W Gant; David R Ferry; Andreas J Gescher
Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells.
British journal of cancer 1996;73(9):1063-8.
1996: Reginald Davies; J Budworth; Joan Riley; R Snowden; Andreas J Gescher; Timothy W Gant
Regulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF-7/Dox cell line subclones.
British journal of cancer 1996;73(3):307-15.
1995: Martin G Rowlands; J Budworth; Michael Jarman; IR Hardcastle; R McCague; Andreas J Gescher
Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues.
Biochemical pharmacology 1995;50(5):723-6.
1995: J Budworth; Andreas J Gescher
Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.
FEBS letters 1995;362(2):139-42.
1995: Carol Courage; J Budworth; Andreas J Gescher
Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation.
British journal of cancer 1995;71(4):697-704.
1994: J Prendiville; Alan T McGown; Andreas J Gescher; A J Dickson; Carol Courage; George R Pettit; Derek Crowther; B W Fox
Establishment of a murine leukaemia cell line resistant to the growth-inhibitory effect of bryostatin 1.
British journal of cancer 1994;70(4):573-8.
1994: Andreas J Gescher; A Mantovani
Exploiting tumour biology: novel approaches in cancer therapy. ESBP Otzenhausen Conference, 6-8th September 1993.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(3):205-7.