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Stefania Gessi

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Fabrizio Vincenzi; Pier Giovanni Baraldi; Pier Andrea Borea; Carmen Corciulo; Stefania Gessi; Stefania Merighi; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Martina Targa; Katia Varani
Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models.
Fabrizio Vincenzi; Pier Andrea Borea; Carmen Corciulo; Stefania Gessi; Sarah Giacuzzo; Marcello Govoni; Stefania Merighi; Melissa Padovan; Martina Targa; Katia Varani
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.
Stefania Gessi; Roberto Marci; Stefania Merighi; Prisco Mirandola; Alberto Sensi; Angela Stefanelli; Katia Varani; Alessandra Bonfatti; Pier Andrea Borea; Sergio Fini; Fortunato Vesce
Downregulation of A(1) and A(2B) adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi.

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2013: Fabrizio Vincenzi; Pier Giovanni Baraldi; Pier Andrea Borea; Carmen Corciulo; Stefania Gessi; Stefania Merighi; Giulia Saponaro; Mojgan Aghazadeh Tabrizi; Martina Targa; Katia Varani
Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models.
Pain 2013;154(6):864-73.
2013: Fabrizio Vincenzi; Pier Andrea Borea; Carmen Corciulo; Stefania Gessi; Sarah Giacuzzo; Marcello Govoni; Stefania Merighi; Melissa Padovan; Martina Targa; Katia Varani
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.
PloS one 2013;8(1):e54195.
2012: Stefania Gessi; Roberto Marci; Stefania Merighi; Prisco Mirandola; Alberto Sensi; Angela Stefanelli; Katia Varani; Alessandra Bonfatti; Pier Andrea Borea; Sergio Fini; Fortunato Vesce
Downregulation of A(1) and A(2B) adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi.
Biochimica et biophysica acta 2012;1822(11):1660-70.
2012: Stefania Merighi; Katia Varani; Debora Fazzi; Stefania Gessi; Pier Andrea Borea
Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes.
Pharmacological research : the official journal of the Italian Pharmacological Society 2012;66(5):428-36.
2012: Stefania Merighi; Prisco Mirandola; Katia Varani; Debora Fazzi; Stefania Gessi; Pier Andrea Borea
Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells.
British journal of pharmacology 2012;166(8):2371-85.
2012: Pier Giovanni Baraldi; Stefania Baraldi; Pier Andrea Borea; Sandro Cosconati; Salvatore Di Maro; Stefania Gessi; Luciana Marinelli; Stefania Merighi; Allan R Moorman; Romeo Romagnoli; Giulia Saponaro; Katia Varani; Mojgan Aghazadeh Tabrizi; Delia Preti
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(11):5380-90.
2012: Stefania Merighi; Prisco Mirandola; Carolina Simioni; Katia Varani; Debora Fazzi; Stefania Gessi; Pier Andrea Borea
Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide.
British journal of pharmacology 2012;165(6):1773-88.
2012: Fabrizio Vincenzi; Pier Andrea Borea; Ruggero Cadossi; Carmen Corciulo; Stefania Gessi; Stefania Merighi; Stefania Setti; Martina Targa; Katia Varani
The anti-tumor effect of A3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cells.
PloS one 2012;7(6):e39317.
2011: Stefania Gessi; Stefania Merighi; Angela Stefanelli; Katia Varani; Debora Fazzi; Pier Andrea Borea
Adenosine receptor targeting in health and disease.
Expert opinion on investigational drugs 2011;20(12):1591-609.
2010: Stefania Gessi; Valeria Sacchetto; Eleonora Fogli; Stefania Merighi; Katia Varani; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Edward Leung; Stephen Maclennan; Pier Andrea Borea
Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors.
Biochemical pharmacology 2010;79(10):1483-95.
2010: Katia Varani; Fabrizio Vincenzi; Alice Tosi; Stefania Gessi; Ilaria Casetta; Gino Granieri; Patrik Fazio; Edward Leung; Stephen Maclennan; Enrico Granieri; Pier Andrea Borea
A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(2):587-98.
2010: Stefania Merighi; Carolina Simioni; Stefania Gessi; Katia Varani; Pier Andrea Borea
Binding thermodynamics at the human cannabinoid CB1 and CB2 receptors.
Biochemical pharmacology 2010;79(3):471-7.
2010: Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Glucocorticoid's pharmacology: past, present and future.
Current pharmaceutical design 2010;16(32):3540-53.
2010: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Stefania Gessi; Pier Andrea Borea; Stefania Merighi
Allosteric enhancers of A1 adenosine receptors: state of the art and new horizons for drug development.
Current medicinal chemistry 2010;17(30):3488-502.
2010: Stefania Gessi; Eleonora Fogli; Valeria Sacchetto; Stefania Merighi; Katia Varani; Delia Preti; Edward Leung; Stephen Maclennan; Pier Andrea Borea
Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(1):90-7.
2009: Stefania Merighi; Carolina Simioni; Stefania Gessi; Katia Varani; Prisco Mirandola; Mojgan Aghazadeh Tabrizi; Pier Giovanni Baraldi; Pier Andrea Borea
A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.
Neoplasia (New York, N.Y.) 2009;11(10):1064-73.
2009: Gianluca Aguiari; Katia Varani; Marco Bogo; Alessandra Mangolini; Fabrizio Vincenzi; Chiara Durante; Stefania Gessi; Valeria Sacchetto; Luigi Catizone; Peter Harris; Rosario Rizzuto; Pier Andrea Borea; Laura del Senno
Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells.
Biochimica et biophysica acta 2009;1792(6):531-40.
2008: Katia Varani; Monica De Mattei; Fabrizio Vincenzi; Azzurra Tosi; Stefania Gessi; Stefania Merighi; Agnese Pellati; F Masieri; Alessia Ongaro; Pier Andrea Borea
Pharmacological characterization of P2X1 and P2X3 purinergic receptors in bovine chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(11):1421-9.
2008: Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Pier Andrea Borea; Stefania Gessi
The P2X7 receptor as a therapeutic target.
Expert opinion on therapeutic targets 2008;12(5):647-61.
2008: Katia Varani; Annmarie Surprenant; Fabrizio Vincenzi; Alice Tosi; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Binding thermodynamic characterization of human P2X1 and P2X3 purinergic receptors.
Biochemical pharmacology 2008;75(5):1198-208.
2008: Katia Varani; Monica De Mattei; Fabrizio Vincenzi; Stefania Gessi; Stefania Merighi; Agnese Pellati; Alessia Ongaro; Angelo Caruso; Ruggero Cadossi; Pier Andrea Borea
Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(3):292-304.
2008: Stefania Gessi; Eleonora Fogli; Valeria Sacchetto; Katia Varani; Stefania Merighi; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
Thermodynamics of A2B adenosine receptor binding discriminates agonistic from antagonistic behaviour.
Biochemical pharmacology 2008;75(2):562-9.
2008: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Stefania Gessi; Pier Andrea Borea
Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility.
Chemical reviews 2008;108(1):238-63.
2008: Stefania Gessi; Stefania Merighi; Katia Varani; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
The A3 adenosine receptor: an enigmatic player in cell biology.
Pharmacology & therapeutics 2008;117(1):123-40.
2007: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Carolina Simioni; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.
Molecular pharmacology 2007;72(2):395-406.
2007: Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; LUISA-CARLOTA LÓPEZ-CARA; Delia Preti; Olga Cruz-Lopez; Mojgan Aghazadeh Tabrizi; Allan R Moorman; Stefania Gessi; Eleonora Fogli; Valeria Sacchetto; Pier Andrea Borea
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
Journal of medicinal chemistry 2007;50(15):3706-15.
2007: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells.
Molecular pharmacology 2007;72(1):162-72.
2007: Stefania Gessi; Stefania Merighi; Katia Varani; Elena Cattabriga; Annalisa Benini; Prisco Mirandola; Edward Leung; Stephen Mac Lennan; Claudio F Feo; Stefania Baraldi; Pier Andrea Borea
Adenosine receptors in colon carcinoma tissues and colon tumoral cell lines: focus on the A(3) adenosine subtype.
Journal of cellular physiology 2007;211(3):826-36.
2007: Pier Giovanni Baraldi; Delia Preti; Mojgan Aghazadeh Tabrizi; Francesca Fruttarolo; Giulia Saponaro; Stefania Baraldi; LUISA-CARLOTA LÓPEZ-CARA; Allan R Moorman; Stefania Gessi; Katia Varani; Pier Andrea Borea
N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.
Bioorganic & medicinal chemistry 2007;15(7):2514-27.
2007: Stefania Gessi; Katia Varani; Stefania Merighi; Eleonora Fogli; Valeria Sacchetto; Annalisa Benini; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
Adenosine and lymphocyte regulation.
Purinergic signalling 2007;3(1-2):109-16.
2006: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A₃ adenosine receptor.
Purinergic signalling 2006;2(4):627-32.
2006: Stefania Gessi; Katia Varani; Stefania Merighi; Edward Leung; Stephen Mac Lennan; Pier Giovanni Baraldi; Pier Andrea Borea
Novel selective antagonist radioligands for the pharmacological study of A(2B) adenosine receptors.
Purinergic signalling 2006;2(4):583-8.
2006: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Andrea Borea
Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells.
Biochemical pharmacology 2006;72(1):19-31.
2006: Katia Varani; Gaetano Caramori; Fabrizio Vincenzi; Ian Adcock; Paolo Casolari; Edward Leung; Stephen Maclennan; Stefania Gessi; Silvana Morello; Peter J Barnes; Kazuhiro Ito; K Fan Chung; Giorgio Cavallesco; Gianfranco Azzena; Alberto Papi; Pier Andrea Borea
Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2006;173(4):398-406.
2005: Katia Varani; Stefania Gessi; Stefania Merighi; Fabrizio Vincenzi; Elena Cattabriga; Annalisa Benini; Karl-Norbert Klotz; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Stephen Mac Lennan; Edward Leung; Pier Andrea Borea
Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors.
Biochemical pharmacology 2005;70(11):1601-12.
2005: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Giovanni Baraldi; Pier Andrea Borea
A3 adenosine receptors modulate hypoxia-inducible factor-1alpha expression in human A375 melanoma cells.
Neoplasia (New York, N.Y.) 2005;7(10):894-903.
2005: Katia Varani; Francesco Portaluppi; Stefania Gessi; Stefania Merighi; Fabrizio Vincenzi; Elena Cattabriga; Alessandro Dalpiaz; F Bortolotti; L Belardinelli; Pier Andrea Borea
Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors.
Cellular and molecular life sciences : CMLS 2005;62(19-20):2350-8.
2005: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Cecilia Pancaldi; Youri Szabadkai; Rosario Rizzuto; Karl-Norbert Klotz; Edward Leung; Stephen Mac Lennan; Pier Giovanni Baraldi; Pier Andrea Borea
Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.
Molecular pharmacology 2005;67(6):2137-47.
2005: Stefania Merighi; Annalisa Benini; Prisco Mirandola; Stefania Gessi; Katia Varani; Edward Leung; Stephen Maclennan; Pier Andrea Borea
A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells.
The Journal of biological chemistry 2005;280(20):19516-26.
2005: Daniele Simoni; Marcello Rossi; Valerio Bertolasi; Marinella Roberti; Daniela Pizzirani; Riccardo Rondanin; Riccardo Baruchello; Francesco Paolo Invidiata; Manlio Tolomeo; Stefania Grimaudo; Stefania Merighi; Katia Varani; Stefania Gessi; Pier Andrea Borea; Silvia Marino; Sabrina Cavallini; Clementina Bianchi; Anna Siniscalchi
Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter.
Journal of medicinal chemistry 2005;48(9):3337-43.
2005: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; LUISA-CARLOTA LÓPEZ-CARA; Francesca Fruttarolo; Stefania Merighi; Katia Varani; Stefania Gessi; Pier Andrea Borea
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine ligands, new tools to characterize A3 adenosine receptors in human tumor cell lines.
Current medicinal chemistry 2005;12(11):1319-29.
2004: LUISA-CARLOTA LÓPEZ-CARA; Pier Giovanni Baraldi; Maria Giovanna Pavani; Mojgan Aghazadeh Tabrizi; Allan R Moorman; Francesco Di Virgilio; Elena Cattabriga; Cecilia Pancaldi; Stefania Gessi; Pier Andrea Borea
Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor.
Bioorganic & medicinal chemistry letters 2004;14(22):5709-12.
2004: Stefania Gessi; Elena Cattabriga; Arianna Avitabile; Roberta Gafa'; Roberta Gafà; Luigi Cavazzini; Nicoletta Bianchi; Roberto Gambari; Claudio F Feo; Alberto Liboni; Sergio Gullini; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
Elevated expression of A3 adenosine receptors in human colorectal cancer is reflected in peripheral blood cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5895-901.
2004: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Delia Preti; Andrea Bovero; Francesca Fruttarolo; LUISA-CARLOTA LÓPEZ-CARA; Allan R Moorman; Stefania Gessi; Stefania Merighi; Katia Varani; Pier Andrea Borea
[3H]-MRE 2029-F20, a selective antagonist radioligand for the human A2B adenosine receptors.
Bioorganic & medicinal chemistry letters 2004;14(13):3607-10.
2004: Maura Floreani; Guglielmina Froldi; Maurizio Cavalli; Sergio Bova; Maria Cecilia Giron; Katia Varani; Stefania Gessi; Pier Andrea Borea; Maria Teresa Dorigo; Paola Dorigo
Characterization of intrinsic sympathomimetic activity of carteolol in rat cardiovascular preparations.
Journal of pharmacological sciences 2004;95(1):115-23.
2004: Gianluca Aguiari; Manuela Banzi; Stefania Gessi; Yiqiang Cai; Emanuela Zeggio; Elisa Manzati; Roberta Piva; Elisabetta Lambertini; Luisa Ferrari; Dorien J Peters; Francesco Lanza; Peter C Harris; Pier Andrea Borea; Stefan Somlo; Laura del Senno
Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):884-6.
2004: Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Delia Preti; Andrea Bovero; LUISA-CARLOTA LÓPEZ-CARA; Francesca Fruttarolo; Naser Abdel Zaid; Allan R Moorman; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
Journal of medicinal chemistry 2004;47(6):1434-47.
2004: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Arianna Avitabile; Riccardo Gavioli; Cinzia Fortini; Edward Leung; Stephen Mac Lennan; Pier Andrea Borea
Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation.
Molecular pharmacology 2004;65(3):711-9.
2004: Pier Andrea Borea; Katia Varani; Stefania Gessi; Stefania Merighi; Alessandro Dal Piaz; Paola Gilli; Gastone Gilli
Receptor binding thermodynamics at the neuronal nicotinic receptor.
Current topics in medicinal chemistry 2004;4(3):361-8.
2003: Katia Varani; Stefania Gessi; Stefania Merighi; Valeria Iannotta; Elena Cattabriga; Cecilia Pancaldi; Ruggero Cadossi; Pier Andrea Borea
Alteration of A(3) adenosine receptors in human neutrophils and low frequency electromagnetic fields.
Biochemical pharmacology 2003;66(10):1897-906.
2003: Stefania Merighi; Prisco Mirandola; Katia Varani; Stefania Gessi; Edward Leung; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Pier Andrea Borea
A glance at adenosine receptors: novel target for antitumor therapy.
Pharmacology & therapeutics 2003;100(1):31-48.
2003: Giorgia Pastorin; Tatiana Da Ros; Giampiero Spalluto; Francesca Deflorian; Stefano Moro; Barbara Cacciari; Pier Giovanni Baraldi; Stefania Gessi; Katia Varani; Pier Andrea Borea
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.
Journal of medicinal chemistry 2003;46(20):4287-96.
2003: Stefania Merighi; Prisco Mirandola; Katia Varani; Stefania Gessi; Silvano Capitani; Edward Leung; Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Pier Andrea Borea
Pyrazolotriazolopyrimidine derivatives sensitize melanoma cells to the chemotherapic drugs: taxol and vindesine.
Biochemical pharmacology 2003;66(5):739-48.
2003: Pier Giovanni Baraldi; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; Delia Preti; LUISA-CARLOTA LÓPEZ-CARA; Hussein El-Kashef; Allan Moorman; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.
Journal of medicinal chemistry 2003;46(7):1229-41.
2003: Maura Floreani; Paola Fossa; Stefania Gessi; Luisa Mosti; Pier Andrea Borea; Paola Dorigo
New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(2):109-18.
2002: Stefania Merighi; Prisco Mirandola; Daniela Milani; Katia Varani; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.
The Journal of investigative dermatology 2002;119(4):923-33.
2002: Giuseppe Caliendo; Ferdinando Fiorino; Elisa Perissutti; Beatrice Severino; Daniela Scolaro; Stefania Gessi; Elena Cattabriga; Pier Andrea Borea; Vincenzo Santagada
A convenient synthesis by microwave heating and pharmacological evaluation of novel benzoyltriazole and saccharine derivatives as 5-HT(1A) receptor ligands.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;16(1-2):15-28.
2002: Katia Varani; Stefania Gessi; Stefania Merighi; Valeria Iannotta; Elena Cattabriga; Susanna Spisani; Ruggero Cadossi; Pier Andrea Borea
Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils.
British journal of pharmacology 2002;136(1):57-66.
2002: Pier Giovanni Baraldi; Barbara Cacciari; Stefano Moro; Giampiero Spalluto; Giorgia Pastorin; Tatiana Da Ros; Karl-Norbert Klotz; Katia Varani; Stefania Gessi; Pier Andrea Borea
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(4):770-80.
2002: Stefania Gessi; Katia Varani; Stefania Merighi; Elena Cattabriga; Valeria Iannotta; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.
Molecular pharmacology 2002;61(2):415-24.
2002: Stefania Merighi; Katia Varani; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Pier Andrea Borea
Binding thermodynamics at the human A(3) adenosine receptor.
Biochemical pharmacology 2002;63(2):157-61.
2001: Giuseppe Caliendo; Ferdinando Fiorino; Elisa Perissutti; Beatrice Severino; Stefania Gessi; Elena Cattabriga; Pier Andrea Borea; Vincenzo Santagada
Synthesis by microwave irradiation and binding properties of novel 5-HT(1A) receptor ligands.
European journal of medicinal chemistry 2001;36(11-12):873-86.
2001: Stefania Merighi; Katia Varani; Stefania Gessi; Elena Cattabriga; Valeria Iannotta; C Ulouglu; Edward Leung; Pier Andrea Borea
Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line.
British journal of pharmacology 2001;134(6):1215-26.
2001: Stefania Gessi; Katia Varani; Stefania Merighi; Antonio Morelli; Davide Ferrari; Edward Leung; Pier Giovanni Baraldi; Giampiero Spalluto; Pier Andrea Borea
Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells.
British journal of pharmacology 2001;134(1):116-26.
2001: Pier Giovanni Baraldi; Barbara Cacciari; Stefano Moro; LUISA-CARLOTA LÓPEZ-CARA; Kenneth Alan Jacobson; Stefania Gessi; Pier Andrea Borea; Giampiero Spalluto
Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.
Journal of medicinal chemistry 2001;44(17):2735-42.
2001: Daniele Simoni; Marinella Roberti; Riccardo Rondanin; Riccardo Baruchello; Marcello Rossi; Francesco Paolo Invidiata; Stefania Merighi; Katia Varani; Stefania Gessi; Pier Andrea Borea; Silvia Marino; Sabrina Cavallini; Clementina Bianchi; Anna Siniscalchi
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter.
Bioorganic & medicinal chemistry letters 2001;11(6):823-7.
2000: P G Baraldi; Barbara Cacciari; R Romagnoli; Giampiero Spalluto; Stefano Moro; Karl-Norbert Klotz; E Leung; K Varani; Stefania Gessi; Stefania Merighi; P A Borea
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.
Journal of medicinal chemistry 2000;43(25):4768-80.
2000: Luisa Mosti; Giulia Menozzi; Paola Fossa; Walter Filippelli; Stefania Gessi; Barbara Rinaldi; Giuseppe Falcone
Synthesis and preliminary biological evaluation of novel N-substituted 1-amino-3-[1-methyl(phenyl)-1H-indazol-4-yloxy]-propan-2-ols interesting as potential antiarrhythmic, local anaesthetic and analgesic agents.
Arzneimittel-Forschung 2000;50(11):963-72.
2000: Remo Guerrini; Girolamo Caló; Raffaella Bigoni; Anna Rizzi; Katia Varani; Géza Toth; Stefania Gessi; Eiji Hashiba; Y Hashimoto; David G Lambert; Pier Andrea Borea; Roberto Tomatis; Severo Salvadori; Domenico Regoli
Further studies on nociceptin-related peptides: discovery of a new chemical template with antagonist activity on the nociceptin receptor.
Journal of medicinal chemistry 2000;43(15):2805-13.
2000: Katia Varani; Francesco Portaluppi; Stefania Gessi; Stefania Merighi; Ennio Ongini; L Belardinelli; Pier Andrea Borea
Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors : functional and biochemical aspects.
Circulation 2000;102(3):285-9.
2000: Katia Varani; Stefania Merighi; Stefania Gessi; Karl-Norbert Klotz; Edward Leung; Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Pier Andrea Borea
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
Molecular pharmacology 2000;57(5):968-75.
2000: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Katia Varani; Stefania Merighi; Stefania Gessi; Pier Andrea Borea; Edward Leung; S L Hickey; Giampiero Spalluto
Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.
Bioorganic & medicinal chemistry letters 2000;10(3):209-11.
2000: Francesco Portaluppi; Roberto Manfredini; Katia Varani; Stefania Gessi; A Caiazza; Pier Andrea Borea
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension are normalized after treatment with doxazosin but not propranolol.
Journal of hypertension 2000;18(2):217-21.
2000: Stefania Gessi; Katia Varani; Stefania Merighi; Ennio Ongini; Pier Andrea Borea
A(2A) adenosine receptors in human peripheral blood cells.
British journal of pharmacology 2000;129(1):2-11.
1999: Pier Giovanni Baraldi; Barbara Cacciari; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Karl-Norbert Klotz; E Leung; Katia Varani; Stefania Gessi; Stefania Merighi; Pier Andrea Borea
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.
Journal of medicinal chemistry 1999;42(22):4473-8.
1999: Katia Varani; Anna Rizzi; Girolamo Calo; Raffaella Bigoni; Géza Toth; Remo Guerrini; Stefania Gessi; Severo Salvadori; Pier Andrea Borea; Domenico Regoli
Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(3):270-7.
1999: Anna Siniscalchi; Donata Rodi; Stefania Gessi; F Campi; Pier Andrea Borea
Early changes in adenosine A1 receptors in cerebral cortex slices submitted to in vitro ischemia.
Neurochemistry international 1999;34(6):517-22.
1999: Katia Varani; Stefania Gessi; A Caiazza; G Rastelli; Francesco Portaluppi; Pier Andrea Borea
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension.
British journal of clinical pharmacology 1999;47(2):167-72.
1999: Gianni Bregola; Katia Varani; Stefania Gessi; Lorenzo Beani; Clementina Bianchi; Pier Andrea Borea; Domenico Regoli; Michele Simonato
Changes in hippocampal and cortical B1 bradykinin receptor biological activity in two experimental models of epilepsy.
Neuroscience 1999;92(3):1043-9.
1999: Stefania Gessi; Alessandro Dalpiaz; Katia Varani; Pier Andrea Borea
Temperature dependence and GABA modulation of beta-carboline binding to rat cerebellum benzodiazepine receptors.
Life sciences 1999;64(16):PL185-92.
1999: Stefania Gessi; F Campi; Katia Varani; Pier Andrea Borea
Alpha2-adrenergic agonist modulation of [35S]GTPgammaS binding to guanine-nucleotide-binding-proteins in human platelet membranes.
Life sciences 1999;64(16):1403-13.
1999: Ennio Ongini; S Dionisotti; Stefania Gessi; E Irenius; Bertil B. Fredholm
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(1):7-10.
1998: Pier Andrea Borea; Katia Varani; Stefania Gessi; Paola Gilli; Gastone Gilli
Binding thermodynamics at the human neuronal nicotine receptor.
Biochemical pharmacology 1998;55(8):1189-97.
1998: Pier Andrea Borea; Katia Varani; Stefania Gessi; Paola Gilli; Alessandro Dalpiaz
Receptor binding thermodynamics as a tool for linking drug efficacy and affinity.
Farmaco (Società chimica italiana : 1989) 1998;53(4):249-54.
1998: Katia Varani; Stefania Gessi; S Dionisotti; Ennio Ongini; Pier Andrea Borea
[3H]-SCH 58261 labelling of functional A2A adenosine receptors in human neutrophil membranes.
British journal of pharmacology 1998;123(8):1723-31.
1997: Stefania Gessi; Anna Rizzi; Girolamo Calò; G Agnello; G Jorizzo; Gioacchino Mollica; Pier Andrea Borea; Domenico Regoli
Human vascular kinin receptors of the B2 type characterized by radioligand binding.
British journal of pharmacology 1997;122(7):1450-4.
1997: Maura Floreani; Pier Andrea Borea; Stefania Gessi; Luisa Mosti; Paola Fossa; Paola Dorigo
A new milrinone analog: role of binding to A1 adenosine receptor in its positive inotropic effect on isolated guinea pig and rat atria.
The Journal of pharmacology and experimental therapeutics 1997;283(2):541-7.
1997: Katia Varani; Stefania Gessi; Alessandro Dalpiaz; Ennio Ongini; Pier Andrea Borea
Characterization of A2A adenosine receptors in human lymphocyte membranes by [3H]-SCH 58261 binding.
British journal of pharmacology 1997;122(2):386-92.
1997: Alessandro Dalpiaz; Stefania Gessi; K Varani; P A Borea
De novo analysis of receptor binding affinity data of 8-ethenyl-xanthine antagonists to adenosine A1 and A2a receptors.
Arzneimittel-Forschung 1997;47(5):591-4.
1996: Alessandro Dalpiaz; Pier Andrea Borea; Stefania Gessi; G Gilli
Binding thermodynamics of 5-HT1A receptor ligands.
European journal of pharmacology 1996;312(1):107-14.
1996: L Guerra; Elisabetta Cerbai; Stefania Gessi; Pier Andrea Borea; Alessandro Mugelli
The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes.
British journal of pharmacology 1996;118(5):1278-84.
1996: Katia Varani; Stefania Gessi; Alessandro Dalpiaz; Pier Andrea Borea
Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding.
British journal of pharmacology 1996;117(8):1693-701.
1996: Pier Andrea Borea; Alessandro Dalpiaz; Stefania Gessi; G Gilli
Thermodynamics of 5-HT3 receptor binding discriminates agonistic from antagonistic behaviour.
European journal of pharmacology 1996;298(3):329-34.
1996: Pier Andrea Borea; Alessandro Dalpiaz; Katia Varani; Stefania Gessi; G Gilli
Binding thermodynamics at A1 and A2A adenosine receptors.
Life sciences 1996;59(17):1373-88.
1995: Alessandro Dalpiaz; Stefania Gessi; Pier Andrea Borea; G Gilli
Binding thermodynamics of serotonin to rat-brain 5-HT1A, 5HT2A and 5-HT3 receptors.
Life sciences 1995;57(12):PL141-6.