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Manfred Gessler

Research Profile

Disorders

Living Beings

Mouse

Anatomy

Chromosomes, Human, Pair 11

Concepts & Ideas

Procedures

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Gene Expression Regulation, Developmental

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Publications

TOP 3
Jana Schmitt; Jenny Wegert; Nasenien Nourkami-Tutdibi; Rhoikos Furtwängler; Manfred Gessler; Norbert Graf; Paul Grundy; Nunja Habel; Sabrina Heisel; Andreas Keller; Petra Leidinger; Hans-Peter Lenhof; Nicole Ludwig; Eckart Meese
Multicenter study identified molecular blood-born protein signatures for Wilms Tumor.
Julia Heisig; Susanne Kneitz; Wing-Kin Sung; David Weber; Chia-Lin Wei; Anja Winkler; Elmar Wolf; Martin Eilers; Eva Englberger; Manfred Gessler
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.
Xiaolin Tu; Cornelia Wiese; kameswaran surendran; Jianquan Chen; Manfred Gessler; Julia Heisig; Courtney M Karner; Raphael Kopan; Seung-Yon Lee; Joohyun Lim; Fanxin Long
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.

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All Publications

2012: Jana Schmitt; Jenny Wegert; Nasenien Nourkami-Tutdibi; Rhoikos Furtwängler; Manfred Gessler; Norbert Graf; Paul Grundy; Nunja Habel; Sabrina Heisel; Andreas Keller; Petra Leidinger; Hans-Peter Lenhof; Nicole Ludwig; Eckart Meese
Multicenter study identified molecular blood-born protein signatures for Wilms Tumor.
International journal of cancer. Journal international du cancer 2012;131(3):673-82.
2012: Julia Heisig; Susanne Kneitz; Wing-Kin Sung; David Weber; Chia-Lin Wei; Anja Winkler; Elmar Wolf; Martin Eilers; Eva Englberger; Manfred Gessler
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.
PLoS genetics 2012;8(5):e1002728.
2012: Xiaolin Tu; Cornelia Wiese; kameswaran surendran; Jianquan Chen; Manfred Gessler; Julia Heisig; Courtney M Karner; Raphael Kopan; Seung-Yon Lee; Joohyun Lim; Fanxin Long
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.
PLoS genetics 2012;8(3):e1002577.
2012: Jenny Wegert; Sabrina Bausenwein; Eva Geissinger; Norbert Graf; Sabine Roth; Manfred Gessler
Characterization of primary Wilms tumor cultures as an in vitro model.
Genes, chromosomes & cancer 2012;51(1):92-104.
2009: Jenny Wegert; Stefanie Wittmann; Ivo Leuschner; Eva Geissinger; Norbert Graf; Manfred Gessler
WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact.
Genes, chromosomes & cancer 2009;48(12):1102-11.
2008: Stefanie Wittmann; Christian Wunder; Birgit Zirn; Rhoikos Furtwängler; Jenny Wegert; Norbert Graf; Manfred Gessler
New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors.
Genes, chromosomes & cancer 2008;47(5):386-95.
2007: Barbara Probst; Rebecca Rock; Manfred Gessler; Andrea Vortkamp; Andreas W Püschel
The rodent Four-jointed ortholog Fjx1 regulates dendrite extension.
Developmental biology 2007;312(1):461-70.
2007: Verena Muthig; Ralf Gilsbach; Miriam Haubold; Melanie Philipp; Tomi Ivacevic; Manfred Gessler; Lutz Hein
Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice.
Circulation research 2007;101(7):682-91.
2007: Andreas Fischer; Christian Steidl; Toni Wagner; Esra Lang; Peter M Jakob; Peter Friedl; Klaus-Peter Knobeloch; Manfred Gessler
Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.
Circulation research 2007;100(6):856-63.
2007: Stefanie Wittmann; Birgit Zirn; Muhannad Alkassar; Peter Ambros; Norbert Graf; Manfred Gessler
Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis.
Genes, chromosomes & cancer 2007;46(2):163-70.
2007: Andreas Fischer; Manfred Gessler
Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors.
Nucleic acids research 2007;35(14):4583-96.
2007: Holger Diez; Andreas Fischer; Anja Winkler; Cheng-Jun Hu; Antonis K Hatzopoulos; Georg Breier; Manfred Gessler
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate.
Experimental cell research 2007;313(1):1-9.
2006: Magdalena Benetkiewicz; Teresita Díaz de Ståhl; Anita Gördör; Susan Pfeifer; Stefanie Wittmann; Manfred Gessler; Jan P Dumanski
Identification of limited regions of genetic aberrations in patients affected with Wilms' tumor using a tiling-path chromosome 22 array.
International journal of cancer. Journal international du cancer 2006;119(3):571-8.
2006: Birgit Zirn; Birgit Samans; Stefanie Wittmann; Torsten Pietsch; Ivo Leuschner; Norbert Graf; Manfred Gessler
Target genes of the WNT/beta-catenin pathway in Wilms tumors.
Genes, chromosomes & cancer 2006;45(6):565-74.
2006: Birgit Zirn; O Hartmann; Birgit Samans; Michael Krause; Stefanie Wittmann; F Mertens; Norbert Graf; Martin Eilers; Manfred Gessler
Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters.
International journal of cancer. Journal international du cancer 2006;118(8):1954-62.
2005: Anaid Mees; Rebecca Rock; Francesca D Ciccarelli; Cornelia B Leberfinger; Johanna M Borawski; Peer Bork; Stefan Wiese; Manfred Gessler; Eugen Kerkhoff
Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases.
Gene expression patterns : GEP 2005;6(1):79-85.
2005: Rebecca Rock; Achim C Heinrich; Nina Schumacher; Manfred Gessler
Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;234(3):602-12.
2005: Rebecca Rock; Sabrina Schrauth; Manfred Gessler
Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;234(3):747-55.
2005: Andreas Fischer; Jürgen Klattig; Burkhard Kneitz; Holger Diez; Manfred Maier; Bettina Holtmann; Christoph Englert; Manfred Gessler
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts.
Molecular and cellular biology 2005;25(20):8960-70.
2005: Birgit Zirn; Birgit Samans; Christian Spangenberg; Norbert Graf; Martin Eilers; Manfred Gessler
All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo.
Oncogene 2005;24(33):5246-51.
2005: Birgit Zirn; Stefanie Wittmann; Manfred Gessler
Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2005;45(6):1100-4.
2005: Birgit Zirn; Stefanie Wittmann; Norbert Graf; Manfred Gessler
Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development.
Cancer letters 2005;220(1):115-20.
2005: Jürgen Brandt; Sabrina Schrauth; Anne-Marie Veith; Alexander Froschauer; Torsten Haneke; Christina Schultheis; Manfred Gessler; Cornelia Leimeister; Jean-Nicolas Volff
Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.
Gene 2005;345(1):101-11.
2004: Andreas Fischer; Barbara Klamt; Nina Schumacher; Christiane Glaeser; Ingo Hansmann; Hartmut Fenge; Manfred Gessler
Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(9):711-6.
2004: Harun Elmasri; Daniel Liedtke; Genia Lücking; Jean-Nicolas Volff; Manfred Gessler; Christoph Winkler
her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes).
Gene expression patterns : GEP 2004;4(5):553-9.
2004: Cornelia Leimeister; Nina Schumacher; Holger Diez; Manfred Gessler
Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;230(2):371-7.
2004: Nina Schumacher; Johanna M Borawski; Cornelia B Leberfinger; Manfred Gessler; Eugen Kerkhoff
Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain.
Gene expression patterns : GEP 2004;4(3):249-55.
2004: Andreas Fischer; Nina Schumacher; Manfred Maier; Michael Sendtner; Manfred Gessler
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.
Genes & development 2004;18(8):901-11.
2003: Christoph Winkler; Harun Elmasri; Barbara Klamt; Jean-Nicolas Volff; Manfred Gessler
Characterization of hey bHLH genes in teleost fish.
Development genes and evolution 2003;213(11):541-53.
2003: Cornelia Leimeister; Nina Schumacher; Manfred Gessler
Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.
Gene expression patterns : GEP 2003;3(5):595-8.
2003: Andreas Fischer; Manfred Gessler
Hey genes in cardiovascular development.
Trends in cardiovascular medicine 2003;13(6):221-6.
2002: Manfred Gessler; Klaus-Peter Knobeloch; Armin Helisch; Kerstin Amann; Nina Schumacher; Elvira Rohde; Andreas Fischer; Cornelia Leimeister
Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice.
Current biology : CB 2002;12(18):1601-4.
2002: Cornelia Leimeister; Christian Steidl; Nina Schumacher; Sabine Erhard; Manfred Gessler
Developmental expression and biochemical characterization of Emu family members.
Developmental biology 2002;249(2):204-18.
2002: Melanie Philipp; Marc Brede; Kerstin Hadamek; Manfred Gessler; Martin J Lohse; Lutz Hein
Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo.
Nature genetics 2002;31(3):311-5.
2002: Andreas Fischer; Cornelia Leimeister; Christoph Winkler; Nina Schumacher; Barbara Klamt; Harun Elmasri; Christian Steidl; Manfred Maier; Klaus-Peter Knobeloch; Kerstin Amann; Armin Helisch; Michael Sendtner; Manfred Gessler
Hey bHLH factors in cardiovascular development.
Cold Spring Harbor symposia on quantitative biology 2002;67():63-70.
2000: Cornelia Leimeister; K Dale; Andreas Fischer; Barbara Klamt; M Hrabe de Angelis; F Radtke; MJ McGrew; Olivier Pourquié; Manfred Gessler
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors.
Developmental biology 2000;227(1):91-103.
2000: Cornelia Leimeister; Nina Schumacher; Christian Steidl; Manfred Gessler
Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos.
Mechanisms of development 2000;98(1-2):175-8.
2000: M M Maier; Manfred Gessler
Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.
Biochemical and biophysical research communications 2000;275(2):652-60.
2000: S Schulz; Karl-Friedrich Becker; E Braungart; C Reichmuth; Barbara Klamt; Ingrid Becker; M Atkinson; Manfred Gessler; Heinz Höfler
Molecular analysis of E-cadherin and cadherin-11 in Wilms' tumours.
The Journal of pathology 2000;191(2):162-9.
2000: Christian Steidl; Cornelia Leimeister; Barbara Klamt; Manfred Maier; Indrajit Nanda; M Dixon; R Clarke; Michael Schmid; Manfred Gessler
Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.
Genomics 2000;66(2):195-203.
2000: Meei-Hua Lin; Cornelia Leimeister; Manfred Gessler; Raphael Kopan
Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers.
Development (Cambridge, England) 2000;127(11):2421-32.
1999: B Gawin; A Niederführ; Nina Schumacher; Holger Hummerich; P F Little; Manfred Gessler
A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1.
Genome research 1999;9(11):1074-86.
1999: Cornelia Leimeister; A Externbrink; Barbara Klamt; Manfred Gessler
Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.
Mechanisms of development 1999;85(1-2):173-7.
1999: Ruth Ashery-Padan; Gonzalo Alvarez-Bolado; Barbara Klamt; Manfred Gessler; Peter Gruss
Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain.
Mechanisms of development 1999;80(2):213-7.
1999: Cornelia Leimeister; A Bach; A S Woolf; Manfred Gessler
Screen for genes regulated during early kidney morphogenesis.
Developmental genetics 1999;24(3-4):273-83.
1998: A Niederführ; Holger Hummerich; B Gawin; S Boyle; P F Little; Manfred Gessler
A sequence-ready 3-Mb PAC contig covering 16 breakpoints of the Wilms tumor/anirida region of human chromosome 11p13.
Genomics 1998;53(2):155-63.
1998: C Thäte; Christoph Englert; Manfred Gessler
Analysis of WT1 target gene expression in stably transfected cell lines.
Oncogene 1998;17(10):1287-94.
1998: Barbara Klamt; M Schulze; C Thäte; Jaroslav Mares; Petr Goetz; Roman Kodet; W Scheulen; Angela Weirich; Norbert Graf; Manfred Gessler
Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters.
Genes, chromosomes & cancer 1998;22(4):287-94.
1998: Cornelia Leimeister; A Bach; Manfred Gessler
Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.
Mechanisms of development 1998;75(1-2):29-42.
1998: R Warneke-Wittstock; Andreas Marquardt; Andrea Gehrig; CG Sauer; Manfred Gessler; Bernhard H F Weber
Transcript map of a 900-kb genomic region in Xp22.1-p22.2: identification of 12 novel genes.
Genomics 1998;51(1):59-67.
1998: Barbara Klamt; Ania Koziell; Francis Poulat; P Wieacker; Peter J Scambler; Philippe Berta; Manfred Gessler
Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.
Human molecular genetics 1998;7(4):709-14.
1996: S Beck; F Badbanchi; M Otto; N Grzeschik; Juergen Kunz; N Speich; Manfred Gessler; Karl-Heinz Grzeschik
Six new polymorphic microsatellite markers used for the integration of genetic and physical maps of human chromosome 7.
Human genetics 1996;97(6):842-4.
1996: Manfred Gessler; Barbara Klamt; S Tsaoussidou; J A Ellis; J P Luzio
The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse.
Genomics 1996;32(1):169-70.
1995: B Gawin; Barbara Klamt; A König; C Thäte; D Le Paslier; I Chumakov; R Bhogal; G Zehetner; G Bruns; Manfred Gessler
An integrated YAC clone contig for the WAGR region on human chromosome 11p13-p14.1.
Genomics 1995;30(1):37-45.
1995: F Schwartz; R Eisenman; J Knoll; Manfred Gessler; G Bruns
cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.
Genomics 1995;29(2):526-32.
1995: A Vortkamp; Manfred Gessler; Karl-Heinz Grzeschik
Identification of optimized target sequences for the GLI3 zinc finger protein.
DNA and cell biology 1995;14(7):629-34.
1995: C Thäte; J Pongratz; A König; Barbara Klamt; S Tsaoussidou; Michael J Higgins; T Shows; C Jones; Manfred Gessler
CpG island clones for chromosome 11p--a resource for mapping and gene identification.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(6):421-5.
1995: A Vortkamp; C Heid; Manfred Gessler; Karl-Heinz Grzeschik
Isolation and characterization of a cosmid contig for the GCPS gene region.
Human genetics 1995;95(1):82-8.
1994: F Schwartz; R Neve; R Eisenman; Manfred Gessler; G Bruns
A WAGR region gene between PAX-6 and FSHB expressed in fetal brain.
Human genetics 1994;94(6):658-64.
1994: Michael J Higgins; NJ Smilinich; Sheila N J Sait; A Koenig; J Pongratz; Manfred Gessler; C W Richard; MR James; J P Sanford; B W Kim
An ordered NotI fragment map of human chromosome band 11p15.
Genomics 1994;23(1):211-22.
1994: A Vortkamp; Manfred Gessler; D Le Paslier; R Elaswarapu; S Smith; Karl-Heinz Grzeschik
Isolation of a yeast artificial chromosome contig spanning the Greig cephalopolysyndactyly syndrome (GCPS) gene region.
Genomics 1994;22(3):563-8.
1994: Manfred Gessler; A König; K Arden; P Grundy; Stuart H Orkin; S Sallan; C Peters; S Ruyle; J Mandell; Frederick P Li
Infrequent mutation of the WT1 gene in 77 Wilms' Tumors.
Human mutation 1994;3(3):212-22.
1993: A König; Sibylle Jakubiczka; Peter Wieacker; H W Schlösser; Manfred Gessler
Further evidence that imbalance of WT1 isoforms may be involved in Denys-Drash syndrome.
Human molecular genetics 1993;2(11):1967-8.
1993: Manfred Gessler; G A Bruns
Sequence of the WT1 upstream region including the Wit-1 gene.
Genomics 1993;17(2):499-501.
1993: Manfred Gessler; A König; J Moore; S Qualman; K Arden; W Cavenee; G Bruns
Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome.
Genes, chromosomes & cancer 1993;7(3):131-6.
1993: I Henry; Jan M N Hoovers; F Barichard; M F Berthéas; A Puech; F Prieur; Manfred Gessler; G Bruns; marcel mannens; Claudine Junien
Pericentric intrachromosomal insertion responsible for recurrence of del(11)(p13p14) in a family.
Genes, chromosomes & cancer 1993;7(1):57-62.
1993: Francis Poulat; D Morin; A König; P Brun; J Giltay; Charles Sultan; R Dumas; Manfred Gessler; Philippe Berta
Distinct molecular origins for Denys-Drash and Frasier syndromes.
Human genetics 1993;91(3):285-6.
1992: Manfred Gessler; A Grupe; Karl-Heinz Grzeschik; O Pongs
The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene.
Human genetics 1992;90(3):319-21.
1992: M Wolf; J Klug; R Hackenberg; Manfred Gessler; Karl-Heinz Grzeschik; Miguel Beato; Guntram Suske
Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines.
Human molecular genetics 1992;1(6):371-8.
1992: Manfred Gessler; A König; G A Bruns
The genomic organization and expression of the WT1 gene.
Genomics 1992;12(4):807-13.
1992: A Vortkamp; T Franz; Manfred Gessler; Karl-Heinz Grzeschik
Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt).
Mammalian genome : official journal of the International Mammalian Genome Society 1992;3(8):461-3.
1991: A Vortkamp; U Thias; Manfred Gessler; W Rosenkranz; Peter M Kroisel; Niels Tommerup; G Krüger; J Götz; L Pelz; Karl-Heinz Grzeschik
A somatic cell hybrid panel and DNA probes for physical mapping of human chromosome 7p.
Genomics 1991;11(3):737-43.
1991: A Vortkamp; Manfred Gessler; Karl-Heinz Grzeschik
GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families.
Nature 1991;352(6335):539-40.
1990: Manfred Gessler; H Hameister; I Henry; C Junien; T Braun; H H Arnold
The human MyoD1 (MYF3) gene maps on the short arm of chromosome 11 but is not associated with the WAGR locus or the region for the Beckwith-Wiedemann syndrome.
Human genetics 1990;86(2):135-8.
1990: Manfred Gessler; A Poustka; W Cavenee; R L Neve; Stuart H Orkin; G A Bruns
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping.
Nature 1990;343(6260):774-8.
1989: Manfred Gessler; G A Bruns
A physical map around the WAGR complex on the short arm of chromosome 11.
Genomics 1989;5(1):43-55.
1989: Manfred Gessler; K O Simola; G A Bruns
Cloning of breakpoints of a chromosome translocation identifies the AN2 locus.
Science (New York, N.Y.) 1989;244(4912):1575-8.
1989: Manfred Gessler; George H Thomas; P Couillin; C Junien; B C McGillivray; M Hayden; G Jaschek; G A Bruns
A deletion map of the WAGR region on chromosome 11.
American journal of human genetics 1989;44(4):486-95.
1988: Manfred Gessler; G A Bruns
Molecular mapping and cloning of the breakpoints of a chromosome 11p14.1-p13 deletion associated with the AGR syndrome.
Genomics 1988;3(2):117-23.