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Diane Gesty-Palmer

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Diane Gesty-Palmer; Michael G Janech; Mi-Hye Lee; Louis M Luttrell; Bronwen Martin; Lam C Tsoi; William H Wood; Ling Yuan; W Jim Zheng; Stuart Maudsley
β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.
Xiaojuan Wang; Farshid Guilak; Shaoxi Liao; Erik Nelson; Richard T Premont; Robert Schmalzigaug; Robert F Spurney; Diane Gesty-Palmer
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.
B N Bohinc; Diane Gesty-Palmer
Biased agonism at the parathyroid hormone receptor: a demonstration of functional selectivity in bone metabolism.

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2013: Diane Gesty-Palmer; Michael G Janech; Mi-Hye Lee; Louis M Luttrell; Bronwen Martin; Lam C Tsoi; William H Wood; Ling Yuan; W Jim Zheng; Stuart Maudsley
β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.
Molecular endocrinology (Baltimore, Md.) 2013;27(2):296-314.
2012: Xiaojuan Wang; Farshid Guilak; Shaoxi Liao; Erik Nelson; Richard T Premont; Robert Schmalzigaug; Robert F Spurney; Diane Gesty-Palmer
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.
Biochemical and biophysical research communications 2012;425(2):407-12.
2012: B N Bohinc; Diane Gesty-Palmer
Biased agonism at the parathyroid hormone receptor: a demonstration of functional selectivity in bone metabolism.
Mini reviews in medicinal chemistry 2012;12(9):856-65.
2011: Erik Nelson; Jeffrey C Rathmell; Michihisa Umetani; Xiaojuan Wang; Carolyn D DuSell; Glenda Evans; Diane Gesty-Palmer; Matthew K Howe; Sundeep Khosla; Ryan Michalek; Donald P McDonnell
The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.
Endocrinology 2011;152(12):4691-705.
2011: Diane Gesty-Palmer; Louis M Luttrell
'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?
British journal of pharmacology 2011;164(1):59-67.
2011: Brittany N Bohinc; Diane Gesty-Palmer
β-arrestin-biased agonism at the parathyroid hormone receptor uncouples bone formation from bone resorption.
Endocrine, metabolic & immune disorders drug targets 2011;11(2):112-9.
2011: James Koh; Moahad Dar; Brian R Untch; Darshana Dixit; Yuhong Shi; Zhao Yang; Mohamed Abdelgadir Adam; Holly K Dressman; Xiaojuan Wang; Diane Gesty-Palmer; Jeffrey R Marks; Robert F Spurney; Kirk M Druey; John Olson
Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.
Molecular endocrinology (Baltimore, Md.) 2011;25(5):867-76.
2011: Wanda C Lakey; Susan Spratt; Emily N Vinson; Thomas Weber; Diane Gesty-Palmer; Scott Palmer
Osteoporosis in lung transplant candidates compared to matched healthy controls.
Clinical transplantation 2011;25(3):426-35.
2011: Diane Gesty-Palmer; Louis M Luttrell
Refining efficacy: exploiting functional selectivity for drug discovery.
Advances in pharmacology (San Diego, Calif.) 2011;62():79-107.
2010: Carolyn D DuSell; Erik Nelson; Xiaojuan Wang; Jennifer Abdo; Ulrike I Mödder; Michihisa Umetani; Diane Gesty-Palmer; Norman B Javitt; Sundeep Khosla; Donald P McDonnell
The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.
Endocrinology 2010;151(8):3675-85.
2010: Louis M Luttrell; Diane Gesty-Palmer
Beyond desensitization: physiological relevance of arrestin-dependent signaling.
Pharmacological reviews 2010;62(2):305-30.
2010: Benny J Chen; Divino Deoliveira; Ivan Spasojevic; Gregory D Sempowski; Chen Jiang; Kouros Owzar; Xiaojuan Wang; Diane Gesty-Palmer; J Mark Cline; J Daniel Bourland; Greg Dugan; Sarah K Meadows; Pamela Daher; Garrett G Muramoto; John P Chute; Nelson J Chao
Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.
PloS one 2010;5(6):e11056.
2009: Diane Gesty-Palmer; Pat Flannery; Ling Yuan; Leonor Corsino; Robert Spurney; Robert J Lefkowitz; Louis M Luttrell
A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.
Science translational medicine 2009;1(1):1ra1.
2009: Liming Wang; Diane Gesty-Palmer; Timothy A Fields; Robert F Spurney
Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).
Molecular endocrinology (Baltimore, Md.) 2009;23(9):1455-65.
2008: arun shukla; Jonathan D Violin; Erin J Whalen; Diane Gesty-Palmer; Sudha K Shenoy; Robert J Lefkowitz
Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):9988-93.
2008: Diane Gesty-Palmer; Louis M Luttrell
Heptahelical terpsichory. Who calls the tune?
Journal of receptor and signal transduction research 2008;28(1-2):39-58.
2006: Diane Gesty-Palmer; Minyong Chen; Eric Reiter; Seungkirl Ahn; Christopher D Nelson; Shuntai Wang; Allen E Eckhardt; Conrad L Cowan; Robert F Spurney; Louis M Luttrell; Robert J Lefkowitz
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
The Journal of biological chemistry 2006;281(16):10856-64.
2005: Diane Gesty-Palmer; Hesham M El-Shewy; Trudy A Kohout; Louis M Luttrell
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
The Journal of biological chemistry 2005;280(37):32157-67.
2005: Min Pi; Robert H Oakley; Diane Gesty-Palmer; Rachael D Cruickshank; Robert F Spurney; Louis M Luttrell; L Darryl Quarles
Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.
Molecular endocrinology (Baltimore, Md.) 2005;19(4):1078-87.
2003: Intekhab Ahmed; Diane Gesty-Palmer; Marc K Drezner; Louis M Luttrell
Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
Molecular endocrinology (Baltimore, Md.) 2003;17(8):1607-21.
2003: Akira Tohgo; Eric W Choy; Diane Gesty-Palmer; Kristen L Pierce; Stephane Laporte; Robert H Oakley; Marc G Caron; Robert J Lefkowitz; Louis M Luttrell
The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
The Journal of biological chemistry 2003;278(8):6258-67.
2000: AK Gopal; Vance G Fowler; Manish A Shah; Diane Gesty-Palmer; Kieren Marr; RS McClelland; LK Kong; GS Gottlieb; Kevin Lanclos; J Li; Daniel J Sexton; G Ralph Corey
Prospective analysis of Staphylococcus aureus bacteremia in nonneutropenic adults with malignancy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(5):1110-5.
1999: Vance G Fowler; LK Kong; G Ralph Corey; GS Gottlieb; RS McClelland; Daniel J Sexton; Diane Gesty-Palmer; Lizzie J Harrell
Recurrent Staphylococcus aureus bacteremia: pulsed-field gel electrophoresis findings in 29 patients.
The Journal of infectious diseases 1999;179(5):1157-61.