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Jan Gettemans

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Chemicals & Drugs

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Sarah De Clercq; Aude Guillabert; Evelien Martens; Joël Vandekerckhove; Olivier Zwaenepoel; Jan Gettemans
Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation.
Joy Irobi; Dirk Adriaensen; Bob Asselbergh; Jan Gettemans; Anne Holmgren; Chantal Ceuterick-de Groote; Peter De Jonghe; Vicky De Winter; Rudy Van Coster; Vincent Timmerman
Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients.
Thomas Hubert; Joël Vandekerckhove; Jan Gettemans
Cdk1 and BRCA1 target γ-tubulin to microtubule domains.

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2013: Sarah De Clercq; Aude Guillabert; Evelien Martens; Joël Vandekerckhove; Olivier Zwaenepoel; Jan Gettemans
Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation.
Cellular and molecular life sciences : CMLS 2013;70(5):909-22.
2012: Joy Irobi; Dirk Adriaensen; Bob Asselbergh; Jan Gettemans; Anne Holmgren; Chantal Ceuterick-de Groote; Peter De Jonghe; Vicky De Winter; Rudy Van Coster; Vincent Timmerman
Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients.
Neuromuscular disorders : NMD 2012;22(8):699-711.
2011: Thomas Hubert; Joël Vandekerckhove; Jan Gettemans
Cdk1 and BRCA1 target γ-tubulin to microtubule domains.
Biochemical and biophysical research communications 2011;414(1):240-5.
2011: Thomas Hubert; Sofie Perdu; Joël Vandekerckhove; Jan Gettemans
γ-Tubulin localizes at actin-based membrane protrusions and inhibits formation of stress-fibers.
Biochemical and biophysical research communications 2011;408(2):248-52.
2011: Thomas Hubert; Joël Vandekerckhove; Jan Gettemans
Unconventional actin conformations localize on intermediate filaments in mitosis.
Biochemical and biophysical research communications 2011;406(1):101-6.
2011: Thomas Hubert; Joël Vandekerckhove; Jan Gettemans
Actin and Arp2/3 localize at the centrosome of interphase cells.
Biochemical and biophysical research communications 2011;404(1):153-8.
2010: Tsutomu Oka; Eline Remue; Kris Meerschaert; Berlinda Vanloo; Ciska Boucherie; David Gfeller; Gary D Bader; Sachdev S Sidhu; Joël Vandekerckhove; Jan Gettemans; Marius Sudol
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling.
The Biochemical journal 2010;432(3):461-72.
2010: Eline Remue; Kris Meerschaert; Tsutomu Oka; Ciska Boucherie; Joël Vandekerckhove; Marius Sudol; Jan Gettemans
TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner.
FEBS letters 2010;584(19):4175-80.
2010: Anske Van den Abbeele; Sarah De Clercq; Ariane De Ganck; Veerle De Corte; Berlinda Van Loo; Sameh Hamdy Soror; Vasundara Srinivasan; Jan Steyaert; Joël Vandekerckhove; Jan Gettemans
A llama-derived gelsolin single-domain antibody blocks gelsolin-G-actin interaction.
Cellular and molecular life sciences : CMLS 2010;67(9):1519-35.
2010: Leonardo Almeida-Souza; Sofie Goethals; Vicky de Winter; Ines Dierick; Rodrigo Gallardo; Joost Van Durme; Joy Irobi; Jan Gettemans; Frederic Rousseau; Joost Schymkowitz; Vincent Timmerman; Sophie Janssens
Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy.
The Journal of biological chemistry 2010;285(17):12778-86.
2010: Veerle Delanote; Berlinda Vanloo; Marie Catillon; Evelyne Friederich; Joël Vandekerckhove; Jan Gettemans
An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(1):105-18.
2009: Kris Meerschaert; Moe Phyu Tun; Eline Remue; Ariane De Ganck; Ciska Boucherie; Berlinda Vanloo; Gisèle Degeest; Joël Vandekerckhove; Pascale Zimmermann; Nitin Bhardwaj; Hui Lu; Wonhwa Cho; Jan Gettemans
The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain.
Cellular and molecular life sciences : CMLS 2009;66(24):3951-66.
2009: Thomas Hubert; Joël Vandekerckhove; Jan Gettemans
Exo70-mediated recruitment of nucleoporin Nup62 at the leading edge of migrating cells is required for cell migration.
Traffic (Copenhagen, Denmark) 2009;10(9):1257-71.
2009: Ariane De Ganck; Veerle De Corte; Erik Bruyneel; Marc Bracke; Joel Vandekerckhove; Jan Gettemans
Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells.
International journal of oncology 2009;34(5):1403-9.
2009: Thomas Hubert; Katrien Van Impe; Joël Vandekerckhove; Jan Gettemans
The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle.
Biochemical and biophysical research communications 2009;380(1):166-70.
2008: Thomas Hubert; Katrien Van Impe; Joël Vandekerckhove; Jan Gettemans
The F-actin filament capping protein CapG is a bona fide nucleolar protein.
Biochemical and biophysical research communications 2008;377(2):699-704.
2008: Ariane De Ganck; Veerle De Corte; An Staes; Kris Gevaert; Joël Vandekerckhove; Jan Gettemans
Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells.
Biochemical and biophysical research communications 2008;370(2):269-73.
2008: Katrien Van Impe; Thomas Hubert; Veerle De Corte; Berlinda Vanloo; Ciska Boucherie; Joël Vandekerckhove; Jan Gettemans
A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.
Traffic (Copenhagen, Denmark) 2008;9(5):695-707.
2007: Anske Van den Abbeele; Veerle De Corte; Katrien Van Impe; Erik Bruyneel; Ciska Boucherie; Marc Bracke; Joël Vandekerckhove; Jan Gettemans
Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro.
Cancer letters 2007;255(1):57-70.
2007: Kris Meerschaert; Erik Bruyneel; Olivier De Wever; Berlinda Vanloo; Ciska Boucherie; Marc Bracke; Joël Vandekerckhove; Jan Gettemans
The tandem PDZ domains of syntenin promote cell invasion.
Experimental cell research 2007;313(9):1790-804.
2006: Bassam Janji; Adeline Giganti; Veerle De Corte; Marie Catillon; Erik Bruyneel; Delphine Lentz; Julie Plastino; Jan Gettemans; Evelyne Friederich
Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells.
Journal of cell science 2006;119(Pt 9):1947-60.
2006: Albena Jordanova; Joy Irobi; Florian P Thomas; Patrick Van Dijck; Kris Meerschaert; Maarten Dewil; Ines Dierick; An Jacobs; Els De Vriendt; Velina Guergueltcheva; Chitharanjan V Rao; Ivailo Tournev; F A A Gondim; Marc D'Hooghe; Veerle Van Gerwen; Patrick Callaerts; Ludo Van Den Bosch; Jean-Pierre Timmermans; Wim Robberecht; Jan Gettemans; Johan M Thevelein; Peter De Jonghe; Ivo Kremensky; Vincent Timmerman
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.
Nature genetics 2006;38(2):197-202.
2005: Ariane De Ganck; Thomas Hubert; Katrien Van Impe; Danny Geelen; Joël Vandekerckhove; Veerle De Corte; Jan Gettemans
A monopartite nuclear localization sequence regulates nuclear targeting of the actin binding protein myopodin.
FEBS letters 2005;579(29):6673-80.
2005: Sophie Desmaret; Lian Qian; Berlinda Vanloo; Kris Meerschaert; Jozef Van Damme; Johan Grooten; Joël Vandekerckhove; Glenn D Prestwich; Jan Gettemans
Lysophosphatidic acid affinity chromatography reveals pyruvate kinase as a specific LPA-binding protein.
Biological chemistry 2005;386(11):1137-47.
2005: Jan Gettemans; Katrien Van Impe; Veerle Delanote; Thomas Hubert; Joël Vandekerckhove; Veerle De Corte
Nuclear actin-binding proteins as modulators of gene transcription.
Traffic (Copenhagen, Denmark) 2005;6(10):847-57.
2005: Veerle Delanote; Joël Vandekerckhove; Jan Gettemans
Plastins: versatile modulators of actin organization in (patho)physiological cellular processes.
Acta pharmacologica Sinica 2005;26(7):769-79.
2005: Veerle Delanote; Katrien Van Impe; Veerle De Corte; Erik Bruyneel; Guillaume Vetter; Ciska Boucherie; Marc Mareel; Joël Vandekerckhove; Evelyne Friederich; Jan Gettemans
Molecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin.
Traffic (Copenhagen, Denmark) 2005;6(4):335-45.
2004: Veerle De Corte; Katrien Van Impe; Erik Bruyneel; Ciska Boucherie; Marc Mareel; Joël Vandekerckhove; Jan Gettemans
Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion.
Journal of cell science 2004;117(Pt 22):5283-92.
2004: Oleg V Evgrafov; Irina V Mersiyanova; Joy Irobi; Ludo Van Den Bosch; Ines Dierick; Conrad L Leung; Olga Schagina; Nathalie Verpoorten; Katrien Van Impe; Valeriy Fedotov; Elena L Dadali; Michaela Auer-Grumbach; Christian Windpassinger; Klaus Wagner; Zoran Mitrovic; David Hilton-Jones; Kevin Talbot; Jean-Jacques Martin; Natalia Vasserman; Svetlana Tverskaya; Alexander V Polyakov; Ronald K H Liem; Jan Gettemans; Wim Robberecht; Peter De Jonghe; Vincent Timmerman
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Nature genetics 2004;36(6):602-6.
2004: Joy Irobi; Katrien Van Impe; Pavel Seeman; Albena Jordanova; Ines Dierick; Nathalie Verpoorten; Andrej Michalik; Els De Vriendt; An Jacobs; Veerle Van Gerwen; Krist'l Vennekens; Radim Mazanec; Ivailo Tournev; David Hilton-Jones; Kevin Talbot; Ivo Kremensky; Ludo Van Den Bosch; Wim Robberecht; Joël Van Vandekerckhove; Christine Van Broeckhoven; Jan Gettemans; Peter De Jonghe; Vincent Timmerman
Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy.
Nature genetics 2004;36(6):597-601.
2004: Christian Preisinger; Benjamin Short; Veerle De Corte; Erik Bruyneel; Alexander Haas; Robert Kopajtich; Jan Gettemans; Francis A Barr
YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.
The Journal of cell biology 2004;164(7):1009-20.
2003: Jan Gettemans; Kris Meerschaert; Joël Vandekerckhove; Veerle De Corte
A kelch beta propeller featuring as a G beta structural mimic: reinventing the wheel?
Science's STKE : signal transduction knowledge environment 2003;2003(191):PE27.
2003: Katrien Van Impe; Veerle De Corte; Ludwig Eichinger; Erik Bruyneel; Marc Mareel; Joël Vandekerckhove; Jan Gettemans
The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.
The Journal of biological chemistry 2003;278(20):17945-52.
2002: Veerle De Corte; Erik Bruyneel; Ciska Boucherie; Marc Mareel; Joël Vandekerckhove; Jan Gettemans
Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling.
The EMBO journal 2002;21(24):6781-90.
2002: Tatyana Sklyarova; Veerle De Corte; Kris Meerschaert; Liesbeth Devriendt; Berlinda Vanloo; Juliet Bailey; Lynnette J Cook; Marc Goethals; Jozef Van Damme; Magda Puype; Joël Vandekerckhove; Jan Gettemans
Fragmin60 encodes an actin-binding protein with a C2 domain and controls actin Thr-203 phosphorylation in Physarum plasmodia and sclerotia.
The Journal of biological chemistry 2002;277(42):39840-9.
2002: Pascale Zimmermann; Kris Meerschaert; Gunter Reekmans; Iris Leenaerts; J Victor Small; Joël Vandekerckhove; Guido David; Jan Gettemans
PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane.
Molecular cell 2002;9(6):1215-25.
2002: Davy T'Jampens; Liesbeth Devriendt; Veerle De Corte; Joël Vandekerckhove; Jan Gettemans
Selected BTB/POZ-kelch proteins bind ATP.
FEBS letters 2002;516(1-3):20-6.
2000: Etienne Waelkens; Veerle De Corte; Wilfried Merlevede; Joël Vandekerckhove; Jan Gettemans
A novel endogenous PP2C-like phosphatase dephosphorylates casein kinase II-phosphorylated Physarum fragmin.
Biochemical and biophysical research communications 2000;279(2):438-44.
1999: Jan Gettemans
Introduction to the histology and cell biology of the actin cytoskeleton.
Microscopy research and technique 1999;47(1):1-2.
1999: Davy T'Jampens; Juliet Bailey; Lynnette J Cook; Bruno Constantin; Joël Vandekerckhove; Jan Gettemans
Physarum amoebae express a distinct fragmin-like actin-binding protein that controls in vitro phosphorylation of actin by the actin-fragmin kinase.
European journal of biochemistry / FEBS 1999;265(1):240-50.
1999: Stefan Steinbacher; Patrick R Hof; Ludwig Eichinger; Michael Schleicher; Jan Gettemans; Joël Vandekerckhove; Robert Huber; J Benz
The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.
The EMBO journal 1999;18(11):2923-9.
1999: Veerle De Corte; Hans Demol; Marc Goethals; Jozef Van Damme; Jan Gettemans; Joël Vandekerckhove
Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach.
Protein science : a publication of the Protein Society 1999;8(1):234-41.
1998: Kris Meerschaert; Veerle De Corte; Y De Ville; Joël Vandekerckhove; Jan Gettemans
Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid.
The EMBO journal 1998;17(20):5923-32.
1998: Bruno Constantin; Kris Meerschaert; Joël Vandekerckhove; Jan Gettemans
Disruption of the actin cytoskeleton of mammalian cells by the capping complex actin-fragmin is inhibited by actin phosphorylation and regulated by Ca2+ ions.
Journal of cell science 1998;111 ( Pt 12)():1695-706.
1997: Davy T'Jampens; Kris Meerschaert; Bruno Constantin; Juliet Bailey; Lynnette J Cook; Veerle De Corte; H De Mol; Marc Goethals; Jozef Van Damme; Joël Vandekerckhove; Jan Gettemans
Molecular cloning, over-expression, developmental regulation and immunolocalization of fragminP, a gelsolin-related actin-binding protein from Physarum polycephalum plasmodia.
Journal of cell science 1997;110 ( Pt 10)():1215-26.
1997: Veerle De Corte; Jan Gettemans; Joël Vandekerckhove
Phosphatidylinositol 4,5-bisphosphate specifically stimulates PP60(c-src) catalyzed phosphorylation of gelsolin and related actin-binding proteins.
FEBS letters 1997;401(2-3):191-6.
1996: Veerle De Corte; Jan Gettemans; Etienne Waelkens; Joël Vandekerckhove
In vivo phosphorylation of actin in Physarum polycephalum. Study of the substrate specificity of the actin-fragmin kinase.
European journal of biochemistry / FEBS 1996;241(3):901-8.
1996: Veerle De Corte; Jan Gettemans; Y De Ville; Etienne Waelkens; Joël Vandekerckhove
Fragmin, a microfilament regulatory protein from Physarum polycephalum, is phosphorylated by casein kinase II-type enzymes.
Biochemistry 1996;35(17):5472-80.
1995: Jan Gettemans; Y De Ville; Etienne Waelkens; Joël Vandekerckhove
The actin-binding properties of the Physarum actin-fragmin complex. Regulation by calcium, phospholipids, and phosphorylation.
The Journal of biological chemistry 1995;270(6):2644-51.
1995: Etienne Waelkens; Jan Gettemans; Veerle De Corte; Y De Ville; Jozef Goris; Joël Vandekerckhove; Wilfried Merlevede
Microfilament dynamics: regulation of actin polymerization by actin-fragmin kinase and phosphatases.
Advances in enzyme regulation 1995;35():199-227.
1993: Jan Gettemans; Y De Ville; Joël Vandekerckhove; Etienne Waelkens
Purification and partial amino acid sequence of the actin-fragmin kinase from Physarum polycephalum.
European journal of biochemistry / FEBS 1993;214(1):111-9.
1992: Jan Gettemans; Y De Ville; Joël Vandekerckhove; Etienne Waelkens
Physarum actin is phosphorylated as the actin-fragmin complex at residues Thr203 and Thr202 by a specific 80 kDa kinase.
The EMBO journal 1992;11(9):3185-91.