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Elizabeth Getzoff

Research Profile

Concepts & Ideas

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X Ray Crystallography

Genes & Molecular Sequences

Amino Acid Sequences

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TOP 3
Till Biskup; Elizabeth D Getzoff; Kenichi Hitomi; Asako Okafuji; Bernd Paulus; Stefan Weber; Erik Schleicher
Variable electron transfer pathways in an amphibian cryptochrome: tryptophan versus tyrosine-based radical pairs.
I M Mahaputra Wijaya; Junpei Yamamoto; Yu Zhang; Elizabeth D Getzoff; Kenichi Hitomi; Shigenori Iwai; Tatsuya Iwata; Hideki Kandori
Detection of distinct α-helical rearrangements of cyclobutane pyrimidine dimer photolyase upon substrate binding by Fourier transform infrared spectroscopy.
Daichi Yamada; Yu Zhang; Elizabeth D Getzoff; Kenichi Hitomi; Tatsuya Iwata; Hideki Kandori
Fourier-transform infrared study of the photoactivation process of Xenopus (6-4) photolyase.

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All Publications

2013: Till Biskup; Elizabeth D Getzoff; Kenichi Hitomi; Asako Okafuji; Bernd Paulus; Stefan Weber; Erik Schleicher
Variable electron transfer pathways in an amphibian cryptochrome: tryptophan versus tyrosine-based radical pairs.
The Journal of biological chemistry 2013;288(13):9249-60.
2013: I M Mahaputra Wijaya; Junpei Yamamoto; Yu Zhang; Elizabeth D Getzoff; Kenichi Hitomi; Shigenori Iwai; Tatsuya Iwata; Hideki Kandori
Detection of distinct α-helical rearrangements of cyclobutane pyrimidine dimer photolyase upon substrate binding by Fourier transform infrared spectroscopy.
Biochemistry 2013;52(6):1019-27.
2012: Daichi Yamada; Yu Zhang; Elizabeth D Getzoff; Kenichi Hitomi; Tatsuya Iwata; Hideki Kandori
Fourier-transform infrared study of the photoactivation process of Xenopus (6-4) photolyase.
Biochemistry 2012;51(29):5774-83.
2012: John M Christie; Andrew S Arvai; Kimberly A Hartfield; Kenichi Hitomi; Marcel Mettlen; Ashley J Pratt; John A Tainer; Elizabeth D Getzoff
Structural tuning of the fluorescent protein iLOV for improved photostability.
The Journal of biological chemistry 2012;287(26):22295-304.
2012: Kenichi Hitomi; Shigenori Iwai; John A Tainer; Mika Teranishi; Junpei Yamamoto; Kazuo Yamamoto; Andrew S Arvai; Jun Hidema; Tokuhisa Hirouchi; Chiharu Hitomi; Elizabeth D Getzoff
Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants.
The Journal of biological chemistry 2012;287(15):12060-9.
2012: John M Christie; Andrew S Arvai; Katherine J Baxter; Monika Heilmann; Kenichi Hitomi; Michael Hothorn; Gareth I Jenkins; Sharon M Kelly; Andrew O'Hara; Ashley J Pratt; Brian O Smith; Elizabeth D Getzoff
Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges.
Science (New York, N.Y.) 2012;335(6075):1492-6.
2012: Minh-Hieu Trinh; Shu-wen W Chen; Elizabeth D Getzoff; Michael Odorico; Pierre PAROT; Michael E Pique; Victoria A Roberts; Lynn F Ten Eyck; Jean-Marie Teulon; Jean-Luc Pellequer
Computational reconstruction of multidomain proteins using atomic force microscopy data.
Structure (London, England : 1993) 2012;20(1):113-20.
2011: Masato Kondoh; Pavel Müller; Chiaki Shiraishi; Margaret Ahmad; Elizabeth D Getzoff; Kenichi Hitomi; Masahide Terazima
Light-induced conformational changes in full-length Arabidopsis thaliana cryptochrome.
Journal of molecular biology 2011;413(1):128-37.
2011: Yu Zhang; Tatsuya Iwata; Junpei Yamamoto; Kenichi Hitomi; Shigenori Iwai; Takeshi Todo; Elizabeth D Getzoff; Hideki Kandori
FTIR study of light-dependent activation and DNA repair processes of (6-4) photolyase.
Biochemistry 2011;50(18):3591-8.
2011: Masato Kondoh; Kenichi Hitomi; Junpei Yamamoto; Takeshi Todo; Shigenori Iwai; Elizabeth D Getzoff; Masahide Terazima
Light-induced conformational change and product release in DNA repair by (6-4) photolyase.
Journal of the American Chemical Society 2011;133(7):2183-91.
2010: Stefan Weber; Till Biskup; Asako Okafuji; Anthony R Marino; Thomas Berthold; Gerhard Link; Kenichi Hitomi; Elizabeth D Getzoff; Erik Schleicher; James R Norris
Origin of light-induced spin-correlated radical pairs in cryptochrome.
The journal of physical chemistry. B 2010;114(45):14745-54.
2010: Tatsuya Iwata; Yu Zhang; Kenichi Hitomi; Elizabeth D Getzoff; Hideki Kandori
Key dynamics of conserved asparagine in a cryptochrome/photolyase family protein by fourier transform infrared spectroscopy.
Biochemistry 2010;49(41):8882-91.
2010: Robin J Rosenfeld; Joseph Bonaventura; Blair R Szymczyna; Michael J MacCoss; Andrew S Arvai; John R Yates; John A Tainer; Elizabeth D Getzoff
Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.
The Journal of biological chemistry 2010;285(41):31581-9.
2010: Katharine E Hubbard; Noriyuki Nishimura; Kenichi Hitomi; Elizabeth D Getzoff; Julian I Schroeder
Early abscisic acid signal transduction mechanisms: newly discovered components and newly emerging questions.
Genes & development 2010;24(16):1695-708.
2010: Asako Okafuji; Till Biskup; Kenichi Hitomi; Elizabeth D Getzoff; Gebhard Kaiser; Alfred Batschauer; Adelbert Bacher; Jun Hidema; Mika Teranishi; Kazuo Yamamoto; Erik Schleicher; Stefan Weber
Light-induced activation of class II cyclobutane pyrimidine dimer photolyases.
DNA repair 2010;9(5):495-505.
2010: Zhi-Wen Guan; Mohammad Mahfuzul Haque; Chin-Chuan Wei; Elsa D Garcin; Elizabeth D Getzoff; Dennis J Stuehr
Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer.
The Journal of biological chemistry 2010;285(5):3064-75.
2009: Noriyuki Nishimura; Kenichi Hitomi; Andrew S Arvai; Robert P Rambo; Chiharu Hitomi; Sean R Cutler; Julian I Schroeder; Elizabeth D Getzoff
Structural mechanism of abscisic acid binding and signaling by dimeric PYR1.
Science (New York, N.Y.) 2009;326(5958):1373-9.
2009: Xian-De Liu; Tuhina Mazumdar; Yi Xu; Elizabeth D Getzoff; N Tony Eissa
Identification of a flavin mononucleotide module residue critical for activity of inducible nitrite oxide synthase.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5977-82.
2009: Junpei Yamamoto; Kenichi Hitomi; Ryosuke Hayashi; Elizabeth D Getzoff; Shigenori Iwai
Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction.
Biochemistry 2009;48(39):9306-12.
2009: Kenichi Hitomi; Luciano DiTacchio; Andrew S Arvai; Junpei Yamamoto; Sang-Tae Kim; Takeshi Todo; John A Tainer; Shigenori Iwai; Satchidananda Panda; Elizabeth D Getzoff
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):6962-7.
2009: David S Shin; Michael DiDonato; David P Barondeau; Greg L Hura; Chiharu Hitomi; J Andrew Berglund; Elizabeth D Getzoff; S Craig Cary; John A Tainer
Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.
Journal of molecular biology 2009;385(5):1534-55.
2009: Junpei Yamamoto; Kenichi Hitomi; Ryosuke Hayashi; Elizabeth D Getzoff; Shigenori Iwai
Recognition and reaction mechanisms of the (6-4) photolyase as determined by using a (6-4) photoproduct analog.
Nucleic acids symposium series (2004) 2009;(53):221-2.
2009: Till Biskup; Erik Schleicher; Asako Okafuji; Gerhard Link; Kenichi Hitomi; Elizabeth D Getzoff; Stefan Weber
Direct observation of a photoinduced radical pair in a cryptochrome blue-light photoreceptor.
Angewandte Chemie (International ed. in English) 2009;48(2):404-7.
2008: Elsa D Garcin; Andrew S Arvai; Robin J Rosenfeld; Matt D Kroeger; Brian R Crane; Gunilla Andersson; Glen Andrews; Peter J Hamley; Philip R Mallinder; David J Nicholls; Stephen A St-Gallay; Alan C Tinker; Nigel P Gensmantel; Antonio Mete; David R Cheshire; Stephen Connolly; Dennis J Stuehr; Anders Aberg; Alan V Wallace; John A Tainer; Elizabeth D Getzoff
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nature chemical biology 2008;4(11):700-7.
2007: Blaine R Roberts; John A Tainer; Elizabeth D Getzoff; Dean A Malencik; Sonia R Anderson; Valerie C Bomben; Kathrin R Meyers; P Andrew Karplus; Joseph S Beckman
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.
Journal of molecular biology 2007;373(4):877-90.
2007: Gerald A Rameau; David S Tukey; Elsa D Garcin-Hosfield; Roseann F Titcombe; Charu Misra; Latika Khatri; Elizabeth D Getzoff; Edward B Ziff
Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(13):3445-55.
2007: David P Barondeau; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis.
Journal of the American Chemical Society 2007;129(11):3118-26.
2007: Erik Schleicher; Kenichi Hitomi; Christopher W M Kay; Elizabeth D Getzoff; Takeshi Todo; Stefan Weber
Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase.
The Journal of biological chemistry 2007;282(7):4738-47.
2007: Junpei Yamamoto; Yoshiyuki Tanaka; Kenichi Hitomi; Elizabeth D Getzoff; Shigenori Iwai
Spectroscopic studies on a novel intramolecular hydrogen bond within the (6-4) photoproduct.
Nucleic acids symposium series (2004) 2007;(51):79-80.
2006: Koustubh Panda; Mohammad Mahfuzul Haque; Elsa D Garcin-Hosfield; Deborah Durra; Elizabeth D Getzoff; Dennis J Stuehr
Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase.
The Journal of biological chemistry 2006;281(48):36819-27.
2006: Ronald Brudler; Chris R Gessner; Sheng Li; Sammy Tyndall; Elizabeth D Getzoff; Virgil L Woods
PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry.
Journal of molecular biology 2006;363(1):148-60.
2006: David P Barondeau; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation.
Journal of the American Chemical Society 2006;128(14):4685-93.
2006: David P Barondeau; John A Tainer; Elizabeth D Getzoff
Structural evidence for an enolate intermediate in GFP fluorophore biosynthesis.
Journal of the American Chemical Society 2006;128(10):3166-8.
2005: Timothy I Wood; David P Barondeau; Chiharu Hitomi; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis.
Biochemistry 2005;44(49):16211-20.
2005: Mauro Tiso; David W Konas; Koustubh Panda; Elsa D Garcin; Manisha Sharma; Elizabeth D Getzoff; Dennis J Stuehr
C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.
The Journal of biological chemistry 2005;280(47):39208-19.
2005: Julie L Tubbs; John A Tainer; Elizabeth D Getzoff
Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation.
Biochemistry 2005;44(29):9833-40.
2005: Kenichi Hitomi; Tokitaka Oyama; Seungil Han; Andrew S Arvai; Elizabeth D Getzoff
Tetrameric architecture of the circadian clock protein KaiB. A novel interface for intermolecular interactions and its impact on the circadian rhythm.
The Journal of biological chemistry 2005;280(19):19127-35.
2005: Alexander R Dunn; Wendy Belliston-Bittner; Jay R Winkler; Elizabeth D Getzoff; Dennis J Stuehr; Harry B Gray
Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase.
Journal of the American Chemical Society 2005;127(14):5169-73.
2005: Chin-Chuan Wei; Zhi-Qiang Wang; Deborah Durra; Craig Hemann; Russ Hille; Elsa D Garcin; Elizabeth D Getzoff; Dennis J Stuehr
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.
The Journal of biological chemistry 2005;280(10):8929-35.
2005: David P Barondeau; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Understanding GFP chromophore biosynthesis: controlling backbone cyclization and modifying post-translational chemistry.
Biochemistry 2005;44(6):1960-70.
2004: David P Barondeau; Elizabeth D Getzoff
Structural insights into protein-metal ion partnerships.
Current opinion in structural biology 2004;14(6):765-74.
2004: Jitka Vévodová; Ross M Graham; Evelyne Raux; Heidi L Schubert; David I Roper; Amanda A Brindley; A Ian Scott; Charles A Roessner; N Patrick J Stamford; M Elizabeth Stroupe; Elizabeth D Getzoff; Martin J Warren; Keith S Wilson
Structure/function studies on a S-adenosyl-L-methionine-dependent uroporphyrinogen III C methyltransferase (SUMT), a key regulatory enzyme of tetrapyrrole biosynthesis.
Journal of molecular biology 2004;344(2):419-33.
2004: Elsa D Garcin; Christopher M Bruns; Sarah J Lloyd; David J Hosfield; Mauro Tiso; Ratan Gachhui; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
The Journal of biological chemistry 2004;279(36):37918-27.
2004: David P Barondeau; Carey J Kassmann; Cami K Bruns; John A Tainer; Elizabeth D Getzoff
Nickel superoxide dismutase structure and mechanism.
Biochemistry 2004;43(25):8038-47.
2004: Dennis J Stuehr; Chin-Chuan Wei; Jerome Santolini; Zhi- Qiang Wang; Mika Aoyagi; Elizabeth D Getzoff
Radical reactions of nitric oxide synthases.
Biochemical Society symposium 2004;(71):39-49.
2003: M Elizabeth Stroupe; Helen K Leech; Douglas S Daniels; Martin J Warren; Elizabeth D Getzoff
CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis.
Nature structural biology 2003;10(12):1064-73.
2003: David P Barondeau; Christopher D Putnam; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12111-6.
2003: Michael DiDonato; Lisa Craig; Mary E Huff; Maria M Thayer; Rosa M F Cardoso; Carey J Kassmann; Terence P Lo; Cami K Bruns; Evan T Powers; Jeffery W Kelly; Elizabeth D Getzoff; John A Tainer
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.
Journal of molecular biology 2003;332(3):601-15.
2003: Nancy Sung; Jeffrey I Gordon; George D Rose; Elizabeth D Getzoff; Stephen J Kron; David Mumford; José N Onuchic; Norbert F Scherer; DeWitt L Sumners; Nancy Kopell
Science education. Educating future scientists.
Science (New York, N.Y.) 2003;301(5639):1485.
2003: Elizabeth D Getzoff; Karl N Gutwin; Ulrich K Genick
Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation.
Nature structural biology 2003;10(8):663-8.
2003: Michael J Thompson; Donald Bashford; Louis Noodleman; Elizabeth D Getzoff
Photoisomerization and proton transfer in photoactive yellow protein.
Journal of the American Chemical Society 2003;125(27):8186-94.
2003: Lisa Craig; Ronald K Taylor; Michael E Pique; Brian D Adair; Andrew S Arvai; Mona Singh; Sarah J Lloyd; David S Shin; Elizabeth D Getzoff; Mark Yeager; Katrina T Forest; John A Tainer
Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin.
Molecular cell 2003;11(5):1139-50.
2003: Terry E Meyer; Savitha Devanathan; TT Woo; Elizabeth D Getzoff; Gordon Tollin; Michael A Cusanovich
Site-specific mutations provide new insights into the origin of pH effects and alternative spectral forms in the photoactive yellow protein from Halorhodospira halophila.
Biochemistry 2003;42(11):3319-25.
2003: Chin-Chuan Wei; Zhi-Qiang Wang; Andrew S Arvai; Craig Hemann; Russ Hille; Elizabeth D Getzoff; Dennis J Stuehr
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.
Biochemistry 2003;42(7):1969-77.
2003: Mika Aoyagi; Andrew S Arvai; John A Tainer; Elizabeth D Getzoff
Structural basis for endothelial nitric oxide synthase binding to calmodulin.
The EMBO journal 2003;22(4):766-75.
2003: Ronald Brudler; Kenichi Hitomi; Hiromi Daiyasu; Hiroyuki Toh; Ken-ichi Kucho; Masahiro Ishiura; Minoru Kanehisa; Victoria A Roberts; Takeshi Todo; John A Tainer; Elizabeth D Getzoff
Identification of a new cryptochrome class. Structure, function, and evolution.
Molecular cell 2003;11(1):59-67.
2002: Robin J Rosenfeld; Elsa D Garcin; Koustubh Panda; Gunilla Andersson; Anders Aberg; Alan V Wallace; Garrett M Morris; Arthur J Olson; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.
Biochemistry 2002;41(47):13915-25.
2002: Rosa M F Cardoso; Maria M Thayer; Michael DiDonato; Terence P Lo; Cami K Bruns; Elizabeth D Getzoff; John A Tainer
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase.
Journal of molecular biology 2002;324(2):247-56.
2002: Elizabeth D Getzoff
PASsing a signal: low carbs, less protein.
Chemistry & biology 2002;9(11):1165-6.
2002: Andrew J Gale; Xiao Xu; Jean-Luc Pellequer; Elizabeth D Getzoff; John H Griffin
Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C.
Protein science : a publication of the Protein Society 2002;11(9):2091-101.
2002: Koustubh Panda; Robin J Rosenfeld; Sanjay Ghosh; Abigail L Meade; Elizabeth D Getzoff; Dennis J Stuehr
Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III.
The Journal of biological chemistry 2002;277(34):31020-30.
2002: David P Barondeau; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Structural chemistry of a green fluorescent protein Zn biosensor.
Journal of the American Chemical Society 2002;124(14):3522-4.
2002: Subrata Adak; Alexandrine M Bilwes; Koustubh Panda; David J Hosfield; kulwant aulak; John F McDonald; John A Tainer; Elizabeth D Getzoff; Brian R Crane; Dennis J Stuehr
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):107-12.
2002: Jesus M Castagnetto; Sean W Hennessy; Victoria A Roberts; Elizabeth D Getzoff; John A Tainer; Michael E Pique
MDB: the Metalloprotein Database and Browser at The Scripps Research Institute.
Nucleic acids research 2002;30(1):379-82.
2001: M Aoyagi; Andrew S Arvai; Sanjay Ghosh; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry 2001;40(43):12826-32.
2001: Ronald Brudler; R Rammelsberg; TT Woo; Elizabeth D Getzoff; Klaus Gerwert
Structure of the I1 early intermediate of photoactive yellow protein by FTIR spectroscopy.
Nature structural biology 2001;8(3):265-70.
2000: Ronald Brudler; Terry E Meyer; Ulrich K Genick; Savitha Devanathan; TT Woo; David P Millar; Klaus Gerwert; Michael A Cusanovich; Gordon Tollin; Elizabeth D Getzoff
Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein.
Biochemistry 2000;39(44):13478-86.
2000: Jean-Luc Pellequer; Andrew J Gale; Elizabeth D Getzoff; John H Griffin
Three-dimensional model of coagulation factor Va bound to activated protein C.
Thrombosis and haemostasis 2000;84(5):849-57.
2000: Brian R Crane; Andrew S Arvai; Sanjay Ghosh; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Biochemistry 2000;39(16):4608-21.
2000: Jean-Luc Pellequer; Andrew J Gale; Elizabeth D Getzoff
Blood coagulation: The outstanding hydrophobic residues.
Current biology : CB 2000;10(6):R237-40.
2000: Katrina T Forest; Paul Langford; J Simon Kroll; Elizabeth D Getzoff
Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface.
Journal of molecular biology 2000;296(1):145-53.
2000: E Demchuk; Ulrich K Genick; TT Woo; Elizabeth D Getzoff; Donald Bashford
Protonation states and pH titration in the photocycle of photoactive yellow protein.
Biochemistry 2000;39(5):1100-13.
2000: Andrew J Gale; Jean-Luc Pellequer; Elizabeth D Getzoff; John H Griffin
Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII.
Thrombosis and haemostasis 2000;83(1):78-85.
1999: Brian R Crane; Robin J Rosenfeld; Andrew S Arvai; DK Ghosh; Sanjay Ghosh; John A Tainer; Dennis J Stuehr; Elizabeth D Getzoff
N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
The EMBO journal 1999;18(22):6271-81.
1999: DK Ghosh; Brian R Crane; Sanjay Ghosh; D Wolan; Ratan Gachhui; C Crooks; A Presta; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.
The EMBO journal 1999;18(22):6260-70.
1999: Savitha Devanathan; Ronald Brudler; Benedikt Hessling; TT Woo; Klaus Gerwert; Elizabeth D Getzoff; Michael A Cusanovich; Gordon Tollin
Dual photoactive species in Glu46Asp and Glu46Ala mutants of photoactive yellow protein: a pH-driven color transition.
Biochemistry 1999;38(41):13766-72.
1999: Subrata Adak; C Crooks; Qing Wang; Brian R Crane; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition.
The Journal of biological chemistry 1999;274(38):26907-11.
1999: Sanjay Ghosh; D Wolan; Subrata Adak; Brian R Crane; N S Kwon; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.
The Journal of biological chemistry 1999;274(34):24100-12.
1999: Maria M Thayer; E H Olender; Andrew S Arvai; C K Koike; IL Canestrelli; J D Stewart; Stephen J Benkovic; Elizabeth D Getzoff; Victoria A Roberts
Structural basis for amide hydrolysis catalyzed by the 43C9 antibody.
Journal of molecular biology 1999;291(2):329-45.
1999: Jean-Luc Pellequer; S w Chen; Victoria A Roberts; John A Tainer; Elizabeth D Getzoff
Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding.
Journal of molecular recognition : JMR 1999;12(4):267-75.
1999: Jean-Luc Pellequer; Ronald Brudler; Elizabeth D Getzoff
Biological sensors: More than one way to sense oxygen.
Current biology : CB 1999;9(11):R416-8.
1998: Jean-Luc Pellequer; Andrew J Gale; John H Griffin; Elizabeth D Getzoff
Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains.
Blood cells, molecules & diseases 1998;24(4):448-61.
1998: Savitha Devanathan; Ulrich K Genick; IL Canestrelli; Terry E Meyer; Michael A Cusanovich; Elizabeth D Getzoff; Gordon Tollin
New insights into the photocycle of Ectothiorhodospira halophila photoactive yellow protein: photorecovery of the long-lived photobleached intermediate in the Met100Ala mutant.
Biochemistry 1998;37(33):11563-8.
1998: S E Mylvaganam; Yvonne Paterson; Elizabeth D Getzoff
Structural basis for the binding of an anti-cytochrome c antibody to its antigen: crystal structures of FabE8-cytochrome c complex to 1.8 A resolution and FabE8 to 2.26 A resolution.
Journal of molecular biology 1998;281(2):301-22.
1998: Jean-Luc Pellequer; KA Wager-Smith; Steve A Kay; Elizabeth D Getzoff
Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):5884-90.
1998: Brian R Crane; Andrew S Arvai; DK Ghosh; Chuanyue Wu; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science (New York, N.Y.) 1998;279(5359):2121-6.
1998: Ulrich K Genick; S Michael Soltis; Peter Kuhn; IL Canestrelli; Elizabeth D Getzoff
Structure at 0.85 A resolution of an early protein photocycle intermediate.
Nature 1998;392(6672):206-9.
1997: Brian R Crane; Andrew S Arvai; Ratan Gachhui; Chuanyue Wu; DK Ghosh; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Science (New York, N.Y.) 1997;278(5337):425-31.
1997: Brian R Crane; Lewis Siegel; Elizabeth D Getzoff
Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products.
Biochemistry 1997;36(40):12120-37.
1997: Brian R Crane; Lewis Siegel; Elizabeth D Getzoff
Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange.
Biochemistry 1997;36(40):12101-19.
1997: C L Fisher; Diane E Cabelli; RA Hallewell; P Beroza; Terence P Lo; Elizabeth D Getzoff; John A Tainer
Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase.
Proteins 1997;29(1):103-12.
1997: Maurice Boissinot; S Karnas; James R Lepock; Diane E Cabelli; John A Tainer; Elizabeth D Getzoff; RA Hallewell
Function of the Greek key connection analysed using circular permutants of superoxide dismutase.
The EMBO journal 1997;16(9):2171-8.
1997: Savitha Devanathan; Ulrich K Genick; Elizabeth D Getzoff; Terry E Meyer; Michael A Cusanovich; Gordon Tollin
Preparation and properties of a 3,4-dihydroxycinnamic acid chromophore variant of the photoactive yellow protein.
Archives of biochemistry and biophysics 1997;340(1):83-9.
1997: Ulrich K Genick; Gloria E. Borgstahl; K Ng; Zhong Ren; C Pradervand; P M Burke; Vukica Srajer; Tsu-Yi Teng; Wilfried Schildkamp; Duncan E McRee; John Keith Moffat; Elizabeth D Getzoff
Structure of a protein photocycle intermediate by millisecond time-resolved crystallography.
Science (New York, N.Y.) 1997;275(5305):1471-5.
1997: Ulrich K Genick; Savitha Devanathan; Terry E Meyer; IL Canestrelli; E Williams; Michael A Cusanovich; Gordon Tollin; Elizabeth D Getzoff
Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein.
Biochemistry 1997;36(1):8-14.
1996: Brian R Crane; Elizabeth D Getzoff
The relationship between structure and function for the sulfite reductases.
Current opinion in structural biology 1996;6(6):744-56.
1996: Y Bourne; S M Redford; Howard M Steinman; James R Lepock; John A Tainer; Elizabeth D Getzoff
Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):12774-9.
1996: S E Mylvaganam; C Bonaventura; J Bonaventura; Elizabeth D Getzoff
Structural basis for the root effect in haemoglobin.
Nature structural biology 1996;3(3):275-83.
1996: Katrina T Forest; S L Bernstein; Elizabeth D Getzoff; Magdalene So; G Tribbick; H M Geysen; C D Deal; John A Tainer
Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies.
Infection and immunity 1996;64(2):644-52.
1995: Leslie A Kuhn; C A Swanson; Michael E Pique; John A Tainer; Elizabeth D Getzoff
Atomic and residue hydrophilicity in the context of folded protein structures.
Proteins 1995;23(4):536-47.
1995: H E Parge; Katrina T Forest; M J Hickey; D A Christensen; Elizabeth D Getzoff; John A Tainer
Structure of the fibre-forming protein pilin at 2.6 A resolution.
Nature 1995;378(6552):32-8.
1995: Brian R Crane; Lewis Siegel; Elizabeth D Getzoff
Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions.
Science (New York, N.Y.) 1995;270(5233):59-67.
1995: Gloria E. Borgstahl; D R Williams; Elizabeth D Getzoff
1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore.
Biochemistry 1995;34(19):6278-87.
1995: K Ng; Elizabeth D Getzoff; John Keith Moffat
Optical studies of a bacterial photoreceptor protein, photoactive yellow protein, in single crystals.
Biochemistry 1995;34(3):879-90.
1995: Victoria A Roberts; Elizabeth D Getzoff
Metalloantibody design.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(1):94-100.
1994: M Baca; Gloria E. Borgstahl; Maurice Boissinot; P M Burke; D R Williams; K A Slater; Elizabeth D Getzoff
Complete chemical structure of photoactive yellow protein: novel thioester-linked 4-hydroxycinnamyl chromophore and photocycle chemistry.
Biochemistry 1994;33(48):14369-77.
1994: C L Fisher; Diane E Cabelli; John A Tainer; RA Hallewell; Elizabeth D Getzoff
The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis.
Proteins 1994;19(1):24-34.
1994: R D Bowditch; M Hariharan; E F Tominna; J W Smith; K M Yamada; Elizabeth D Getzoff; Mark H Ginsberg
Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins.
The Journal of biological chemistry 1994;269(14):10856-63.
1994: J D Stewart; Victoria A Roberts; N R Thomas; Elizabeth D Getzoff; Stephen J Benkovic
Site-directed mutagenesis of a catalytic antibody: an arginine and a histidine residue play key roles.
Biochemistry 1994;33(8):1994-2003.
1994: Victoria A Roberts; J Stewart; Stephen J Benkovic; Elizabeth D Getzoff
Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization.
Journal of molecular biology 1994;235(3):1098-116.
1993: Lucia Banci; Diane E Cabelli; Elizabeth D Getzoff; RA Hallewell; Maria Silvia Viezzoli
An essential role for the conserved Glu-133 in the anion interaction with superoxide dismutase.
Journal of inorganic biochemistry 1993;50(2):89-100.
1992: Leslie A Kuhn; M A Siani; Michael E Pique; C L Fisher; Elizabeth D Getzoff; John A Tainer
The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures.
Journal of molecular biology 1992;228(1):13-22.
1992: John A Tainer; Victoria A Roberts; Elizabeth D Getzoff
Protein metal-binding sites.
Current opinion in biotechnology 1992;3(4):378-87.
1992: Elizabeth D Getzoff; Diane E Cabelli; C L Fisher; H E Parge; Maria Silvia Viezzoli; Lucia Banci; RA Hallewell
Faster superoxide dismutase mutants designed by enhancing electrostatic guidance.
Nature 1992;358(6384):347-51.
1991: RA Hallewell; K C Imlay; P Lee; N M Fong; C Gallegos; Elizabeth D Getzoff; John A Tainer; Diane E Cabelli; P Tekamp-Olson; G T Mullenbach
Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines.
Biochemical and biophysical research communications 1991;181(1):474-80.
1991: S E Mylvaganam; Yvonne Paterson; K Kaiser; K Bowdish; Elizabeth D Getzoff
Biochemical implications from the variable gene sequences of an anti-cytochrome c antibody and crystallographic characterization of its antigen-binding fragment in free and antigen-complexed forms.
Journal of molecular biology 1991;221(2):455-62.
1991: John A Tainer; Victoria A Roberts; Elizabeth D Getzoff
Metal-binding sites in proteins.
Current opinion in biotechnology 1991;2(4):582-91.
1991: Victoria A Roberts; H C Freeman; Arthur J Olson; John A Tainer; Elizabeth D Getzoff
Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c.
The Journal of biological chemistry 1991;266(20):13431-41.
1991: John A Tainer; C D Deal; H M Geysen; Victoria A Roberts; Elizabeth D Getzoff
Defining antibody-antigen recognition: towards engineered antibodies and epitopes.
International reviews of immunology 1991;7(2):165-88.
1991: C L Fisher; RA Hallewell; Victoria A Roberts; John A Tainer; Elizabeth D Getzoff
Probing the structural basis for enzyme-substrate recognition in Cu,Zn superoxide dismutase.
Free radical research communications 1991;12-13 Pt 1():287-96.
1991: Victoria A Roberts; C L Fisher; S M Redford; Duncan E McRee; H E Parge; Elizabeth D Getzoff; John A Tainer
Mechanism and atomic structure of superoxide dismutase.
Free radical research communications 1991;12-13 Pt 1():269-78.
1990: Victoria A Roberts; B L Iverson; S A Iverson; Stephen J Benkovic; Richard A Lerner; Elizabeth D Getzoff; John A Tainer
Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6654-8.
1990: C L Fisher; John A Tainer; Michael E Pique; Elizabeth D Getzoff
Visualization of molecular flexibility and its effects on electrostatic recognition.
Journal of molecular graphics 1990;8(3):125-32, 145.
1990: Duncan E McRee; S M Redford; Elizabeth D Getzoff; James R Lepock; RA Hallewell; John A Tainer
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.
The Journal of biological chemistry 1990;265(24):14234-41.
1990: B L Iverson; S A Iverson; Victoria A Roberts; Elizabeth D Getzoff; John A Tainer; Stephen J Benkovic; Richard A Lerner
Metalloantibodies.
Science (New York, N.Y.) 1990;249(4969):659-62.
1990: S M Redford; Duncan E McRee; Elizabeth D Getzoff; Howard M Steinman; John A Tainer
Crystallographic characterization of a Cu,Zn superoxide dismutase from Photobacterium leiognathi.
Journal of molecular biology 1990;212(3):449-51.
1989: Duncan E McRee; John A Tainer; T E Meyer; J Van Beeumen; M A Cusanovich; Elizabeth D Getzoff
Crystallographic structure of a photoreceptor protein at 2.4 A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6533-7.
1989: N C Chien; Victoria A Roberts; A M Giusti; Matthew D Scharff; Elizabeth D Getzoff
Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5532-6.
1989: RA Hallewell; I Laria; A Tabrizi; G Carlin; Elizabeth D Getzoff; John A Tainer; L S Cousens; G T Mullenbach
Genetically engineered polymers of human CuZn superoxide dismutase. Biochemistry and serum half-lives.
The Journal of biological chemistry 1989;264(9):5260-8.
1989: S M Behar; N C Chien; S Corbet; Betty Diamond; Elizabeth D Getzoff; D Lustgarten; Victoria A Roberts; Matthew D Scharff; Seung-Uon Shin
Impact of somatic mutation on the S107(T15) heavy-chain V region of antibodies reactive with self and nonself.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():921-31.
1988: Elizabeth D Getzoff; H E Parge; Duncan E McRee; John A Tainer
Understanding the structure and antigenicity of gonococcal pili.
Reviews of infectious diseases 1988;10 Suppl 2():S296-9.
1988: John A Tainer; RA Hallewell; Victoria A Roberts; H E Parge; Elizabeth D Getzoff
Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase.
Basic life sciences 1988;49():635-40.
1988: Elizabeth D Getzoff; John A Tainer; Richard A Lerner; H M Geysen
The chemistry and mechanism of antibody binding to protein antigens.
Advances in immunology 1988;43():1-98.
1987: H E Parge; Duncan E McRee; M A Capozza; S L Bernstein; Elizabeth D Getzoff; John A Tainer
Three dimensional structure of bacterial pili.
Antonie van Leeuwenhoek 1987;53(6):447-53.
1986: H E Parge; Elizabeth D Getzoff; C S Scandella; RA Hallewell; John A Tainer
Crystallographic characterization of recombinant human CuZn superoxide dismutase.
The Journal of biological chemistry 1986;261(34):16215-8.
1986: Duncan E McRee; T E Meyer; M A Cusanovich; H E Parge; Elizabeth D Getzoff
Crystallographic characterization of a photoactive yellow protein with photochemistry similar to sensory rhodopsin.
The Journal of biological chemistry 1986;261(29):13850-1.