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Jeroen Geurtsen

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Chemicals & Drugs

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Jeroen Geurtsen; Monika Dzieciatkowska; Liana Steeghs; Hendrik-Jan Hamstra; Johanna Boleij; Kelly Broen; Grietsje Akkerman; Hassan El Hassan; Jianjun Li; James C Richards; Jan Tommassen; Peter van der Ley
Identification of a novel lipopolysaccharide core biosynthesis gene cluster in Bordetella pertussis, and influence of core structure and lipid A glucosamine substitution on endotoxic activity.
Jeroen Geurtsen; Floris Fransen; Rob Vandebriel; Eric R Gremmer; Liset J J de la Fonteyne-Blankestijn; Betsy Kuipers; Jan Tommassen; Peter van der Ley
Supplementation of whole-cell pertussis vaccines with lipopolysaccharide analogs: modification of vaccine-induced immune responses.
Jeroen Geurtsen; Eline Angevaare; Marlieke Janssen; Hendrik-Jan Hamstra; Jan ten Hove; Alex de Haan; Betsy Kuipers; Jan Tommassen; Peter van der Ley
A novel secondary acyl chain in the lipopolysaccharide of Bordetella pertussis required for efficient infection of human macrophages.

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All Publications

2009: Jeroen Geurtsen; Monika Dzieciatkowska; Liana Steeghs; Hendrik-Jan Hamstra; Johanna Boleij; Kelly Broen; Grietsje Akkerman; Hassan El Hassan; Jianjun Li; James C Richards; Jan Tommassen; Peter van der Ley
Identification of a novel lipopolysaccharide core biosynthesis gene cluster in Bordetella pertussis, and influence of core structure and lipid A glucosamine substitution on endotoxic activity.
Infection and immunity 2009;77(7):2602-11.
2008: Jeroen Geurtsen; Floris Fransen; Rob Vandebriel; Eric R Gremmer; Liset J J de la Fonteyne-Blankestijn; Betsy Kuipers; Jan Tommassen; Peter van der Ley
Supplementation of whole-cell pertussis vaccines with lipopolysaccharide analogs: modification of vaccine-induced immune responses.
Vaccine 2008;26(7):899-906.
2007: Jeroen Geurtsen; Eline Angevaare; Marlieke Janssen; Hendrik-Jan Hamstra; Jan ten Hove; Alex de Haan; Betsy Kuipers; Jan Tommassen; Peter van der Ley
A novel secondary acyl chain in the lipopolysaccharide of Bordetella pertussis required for efficient infection of human macrophages.
The Journal of biological chemistry 2007;282(52):37875-84.
2007: Jeroen Geurtsen; Rob Vandebriel; Eric R Gremmer; Betsy Kuipers; Jan Tommassen; Peter van der Ley
Consequences of the expression of lipopolysaccharide-modifying enzymes for the efficacy and reactogenicity of whole-cell pertussis vaccines.
Microbes and infection / Institut Pasteur 2007;9(9):1096-103.
2007: Jeroen Geurtsen; H Alexander Banus; Eric R Gremmer; Henke Ferguson; Liset J J de la Fonteyne-Blankestijn; Jolanda P Vermeulen; J A M A Dormans; Jan Tommassen; Peter van der Ley; Frits R Mooi; Rob Vandebriel
Lipopolysaccharide analogs improve efficacy of acellular pertussis vaccine and reduce type I hypersensitivity in mice.
Clinical and vaccine immunology : CVI 2007;14(7):821-9.
2006: Jeroen Geurtsen; Liana Steeghs; Hendrik-Jan Hamstra; Jan ten Hove; Alex de Haan; Betsy Kuipers; Jan Tommassen; Peter van der Ley
Expression of the lipopolysaccharide-modifying enzymes PagP and PagL modulates the endotoxic activity of Bordetella pertussis.
Infection and immunity 2006;74(10):5574-85.
2006: Lucy Rutten; Jeroen Geurtsen; Wietske Lambert; Jeroen J M Smolenaers; Alexandre Bonvin; Alex de Haan; Peter van der Ley; Maarten R Egmond; Piet Gros; Jan Tommassen
Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7071-6.
2005: Jeroen Geurtsen; Liana Steeghs; Jan Ten Hove; Peter van der Ley; Jan Tommassen
Dissemination of lipid A deacylases (pagL) among gram-negative bacteria: identification of active-site histidine and serine residues.
The Journal of biological chemistry 2005;280(9):8248-59.
2005: Boris Tefsen; Jeroen Geurtsen; Frank Beckers; Jan Tommassen; Hans de Cock
Lipopolysaccharide transport to the bacterial outer membrane in spheroplasts.
The Journal of biological chemistry 2005;280(6):4504-9.
2004: Martine P Bos; Boris Tefsen; Jeroen Geurtsen; Jan Tommassen
Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9417-22.
2003: Romé Voulhoux; Martine P Bos; Jeroen Geurtsen; Maarten Mols; Jan Tommassen
Role of a highly conserved bacterial protein in outer membrane protein assembly.
Science (New York, N.Y.) 2003;299(5604):262-5.