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Berhane Ghebrehiwet

Research Profile

Chemicals & Drugs

Physiology

Complement Activation

Anatomy

Phenomena

Protein Binding

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Inflammation

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Berhane Ghebrehiwet; Kinga H Hosszu; Jolyon Jesty; Yan Ji; Nithin Tumma; Alisa Valentino; Rama Vinayagasundaram; Uma Vinayagasundaram; Ellinor I B Peerschke
Targeting gC1qR domains for therapy against infection and inflammation.
Berhane Ghebrehiwet; Kinga H Hosszu; Jolyon Jesty; Yan Ji; Nithin Tumma; Alisa Valentino; Rama Vinayagasundaram; Uma Vinayagasundaram; Ellinor I B Peerschke
Targeting gC1qR Domains for Therapy Against Infection and Inflammation.
Kinga K Hosszu; Yan Ji; M Gordon Joyce; Ellinor I B Peerschke; Alisa Valentino; Rama Vinayagasundaram; Uma Vinayagasundaram; Berhane Ghebrehiwet
DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

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2013: Berhane Ghebrehiwet; Kinga H Hosszu; Jolyon Jesty; Yan Ji; Nithin Tumma; Alisa Valentino; Rama Vinayagasundaram; Uma Vinayagasundaram; Ellinor I B Peerschke
Targeting gC1qR domains for therapy against infection and inflammation.
Advances in experimental medicine and biology 2013;735():97-110.
2013: Berhane Ghebrehiwet; Kinga H Hosszu; Jolyon Jesty; Yan Ji; Nithin Tumma; Alisa Valentino; Rama Vinayagasundaram; Uma Vinayagasundaram; Ellinor I B Peerschke
Targeting gC1qR Domains for Therapy Against Infection and Inflammation.
Advances in experimental medicine and biology 2013;734():97-110.
2012: Kinga K Hosszu; Yan Ji; M Gordon Joyce; Ellinor I B Peerschke; Alisa Valentino; Rama Vinayagasundaram; Uma Vinayagasundaram; Berhane Ghebrehiwet
DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.
Blood 2012;120(6):1228-36.
2012: Francine R Dembitzer; Roberto Garcia; Berhane Ghebrehiwet; Noam Harpaz; Shabnam Jaffer; Yayoi Kinoshita; Mary Beth Beasley; David Burstein; Robert G Phelps; Swan N Thung; Pamela D Unger; Ellinor I Peerschke
gC1qR expression in normal and pathologic human tissues: differential expression in tissues of epithelial and mesenchymal origin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012;60(6):467-74.
2012: Kinga K Hosszu; Yan Ji; Mara Matkovic; Lina Pednekar; Ellinor I B Peerschke; Nina Rehage; Nithin Tumma; Alisa Valentino; Berhane Ghebrehiwet
Cell surface expression and function of the macromolecular c1 complex on the surface of human monocytes.
Frontiers in immunology 2012;3():38.
2011: Glenda Trujillo; Jianhua Zhang; Mahalakshmi Ramadass; Lingyin Ge; Berhane Ghebrehiwet; David M Habiel; Richard R Kew
Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors.
Molecular immunology 2011;49(3):495-503.
2011: Fleur Bossi; Berhane Ghebrehiwet; Ellinor I Peerschke; Francesco Tedesco
Cross-talk between the complement and the kinin system in vascular permeability.
Immunology letters 2011;140(1-2):7-13.
2011: Shneh Sethi; Mathias Herrmann; Jonas Roller; Lutz Von Müller; Ellinor I Peerschke; Berhane Ghebrehiwet; Irma Bajric; Michael D Menger; Matthias W Laschke
Blockade of gC1qR/p33, a receptor for C1q, inhibits adherence of Staphylococcus aureus to the microvascular endothelium.
Microvascular research 2011;82(1):66-72.
2010: Chiara Agostinis; Roberta Bulla; Claudio Tripodo; Angela Gismondi; Helena Stabile; Fleur Bossi; Carla Guarnotta; Cecilia Garlanda; Francesco De Seta; Paola Spessotto; Angela Santoni; Berhane Ghebrehiwet; Guillermina Girardi; Francesco Tedesco
An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4420-9.
2010: Ellinor I Peerschke; Wei Yin; Berhane Ghebrehiwet
Complement activation on platelets: implications for vascular inflammation and thrombosis.
Molecular immunology 2010;47(13):2170-5.
2010: Allen P Kaplan; Berhane Ghebrehiwet
The plasma bradykinin-forming pathways and its interrelationships with complement.
Molecular immunology 2010;47(13):2161-9.
2010: Kinga K Hosszu; Frances Santiago-Schwarz; Ellinor I B Peerschke; Berhane Ghebrehiwet
Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity.
Innate immunity 2010;16(2):115-27.
2009: Fleur Bossi; Fabio Fischetti; Domenico Regoli; Paolo Durigutto; Barbara Frossi; Fernand Gobeil; Berhane Ghebrehiwet; Ellinor I Peerschke; Marco Cicardi; Francesco Tedesco
Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency.
The Journal of allergy and clinical immunology 2009;124(6):1303-10.e4.
2009: Domenico Sansonno; Felicia Anna Tucci; Berhane Ghebrehiwet; Gianfranco Lauletta; Ellinor I B Peerschke; Vincenza Conteduca; Sabino Russi; Pietro Gatti; Loredana Sansonno; Franco Dammacco
Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):6013-20.
2009: E I B Peerschke; W Yin; D R Alpert; Robert A S Roubey; J E Salmon; Berhane Ghebrehiwet
Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies.
Lupus 2009;18(6):530-8.
2008: Wei Yin; Berhane Ghebrehiwet; Ellinor I B Peerschke
Expression of complement components and inhibitors on platelet microparticles.
Platelets 2008;19(3):225-33.
2008: Roberta Bulla; Chiara Agostinis; Fleur Bossi; Lucia Rizzi; Alessandra Debeus; Claudio Tripodo; Oriano Radillo; Francesco De Seta; Berhane Ghebrehiwet; Francesco Tedesco
Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium.
Molecular immunology 2008;45(9):2629-40.
2008: Pascale Tacnet; Eric Chung Chee Cheong; Pierrette Goeltz; Berhane Ghebrehiwet; Gérard J Arlaud; Xiang-Yang Liu; Claire Lesieur
Trimeric reassembly of the globular domain of human C1q.
Biochimica et biophysica acta 2008;1784(3):518-29.
2008: Helena Paidassi; Pascale Tacnet-Delorme; Virginie Garlatti; Claudine Darnault; Berhane Ghebrehiwet; Christine Gaboriaud; Gérard J Arlaud; Philippe Frachet
C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2329-38.
2008: Ellinor I B Peerschke; Wei Yin; Berhane Ghebrehiwet
Platelet mediated complement activation.
Advances in experimental medicine and biology 2008;632():81-91.
2008: Wei Yin; Berhane Ghebrehiwet; Babette Weksler; Ellinor I B Peerschke
Regulated complement deposition on the surface of human endothelial cells: effect of tobacco smoke and shear stress.
Thrombosis research 2008;122(2):221-8.
2007: Wei Yin; Berhane Ghebrehiwet; Babette B Weksler; Ellinor I B Peerschke
Classical pathway complement activation on human endothelial cells.
Molecular immunology 2007;44(9):2228-34.
2007: Berhane Ghebrehiwet; Lee Tantral; Mathew A Titmus; Barbara J Panessa-Warren; George T Tortora; Stanislaus S Wong; John B Warren
The exosporium of B. cereus contains a binding site for gC1qR/p33: implication in spore attachment and/or entry.
Advances in experimental medicine and biology 2007;598():181-97.
2007: Ellinor I B Peerschke; Berhane Ghebrehiwet
The contribution of gC1qR/p33 in infection and inflammation.
Immunobiology 2007;212(4-5):333-42.
2006: Mohammad M Khan; Harlan N Bradford; Irma Isordia-Salas; Yuchuan Liu; Yi Wu; Ricardo G Espinola; Berhane Ghebrehiwet; Robert W Colman
High-molecular-weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1, and gC1qR in monocytes.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2260-6.
2006: Ellinor I B Peerschke; W Yin; S E Grigg; Berhane Ghebrehiwet
Blood platelets activate the classical pathway of human complement.
Journal of thrombosis and haemostasis : JTH 2006;4(9):2035-42.
2006: Ellinor I B Peerschke; Arnold S Bayer; Berhane Ghebrehiwet; Yan-Qiong Xiong
gC1qR/p33 blockade reduces Staphylococcus aureus colonization of target tissues in an animal model of infective endocarditis.
Infection and immunity 2006;74(8):4418-23.
2006: Zsuzsa Vegh; Richard R Kew; Barry L Gruber; Berhane Ghebrehiwet
Chemotaxis of human monocyte-derived dendritic cells to complement component C1q is mediated by the receptors gC1qR and cC1qR.
Molecular immunology 2006;43(9):1402-7.
2006: Berhane Ghebrehiwet; Claudia CebadaMora; Lee Tantral; Jolyon Jesty; Ellinor I B Peerschke
gC1qR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation.
Advances in experimental medicine and biology 2006;586():95-105.
2005: Allen P Kaplan; Berhane Ghebrehiwet
Does C-2 kinin exist?
The Journal of allergy and clinical immunology 2005;115(4):876.
2004: Ellinor I B Peerschke; Ramona J Petrovan; Berhane Ghebrehiwet; Wolfram Ruf
Tissue factor pathway inhibitor-2 (TFPI-2) recognizes the complement and kininogen binding protein gC1qR/p33 (gC1qR): implications for vascular inflammation.
Thrombosis and haemostasis 2004;92(4):811-9.
2004: Daniel B Rubinstein; Alexei Stortchevoi; Michael S Boosalis; Raheela Ashfaq; Berhane Ghebrehiwet; Ellinor I B Peerschke; Fabien Calvo; Thierry Guillaume
Receptor for the globular heads of C1q (gC1q-R, p33, hyaluronan-binding protein) is preferentially expressed by adenocarcinoma cells.
International journal of cancer. Journal international du cancer 2004;110(5):741-50.
2004: Ellinor I B Peerschke; Joe O Minta; Sonya Z Zhou; Alessandra Bini; Avrum Gotlieb; Robert W Colman; Berhane Ghebrehiwet
Expression of gC1q-R/p33 and its major ligands in human atherosclerotic lesions.
Molecular immunology 2004;41(8):759-66.
2004: Berhane Ghebrehiwet; Ellinor I B Peerschke
cC1q-R (calreticulin) and gC1q-R/p33: ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection.
Molecular immunology 2004;41(2-3):173-83.
2004: Berhane Ghebrehiwet; Ellinor I B Peerschke
Role of C1q and C1q receptors in the pathogenesis of systemic lupus erythematosus.
Current directions in autoimmunity 2004;7():87-97.
2004: Kusumam Joseph; Baby G Tholanikunnel; Berhane Ghebrehiwet; Allen P Kaplan
Interaction of high molecular weight kininogen binding proteins on endothelial cells.
Thrombosis and haemostasis 2004;91(1):61-70.
2003: Zsuzsa Vegh; Earl C Goyarts; Kimberly Rozengarten; Amitabha Mazumder; Berhane Ghebrehiwet
Maturation-dependent expression of C1q-binding proteins on the cell surface of human monocyte-derived dendritic cells.
International immunopharmacology 2003;3(3):345-57.
2003: Berhane Ghebrehiwet; Xiaodong Feng; Rajeev Kumar; Ellinor I B Peerschke
Complement component C1q induces endothelial cell adhesion and spreading through a docking/signaling partnership of C1q receptors and integrins.
International immunopharmacology 2003;3(3):299-310.
2003: Ellinor I B Peerschke; Tara K Murphy; Berhane Ghebrehiwet
Activation-dependent surface expression of gC1qR/p33 on human blood platelets.
Thrombosis and haemostasis 2003;89(2):331-9.
2003: Zsuzsa Vegh; Earl C Goyarts; Kimberly Rozengarten; Amitabha Mazumder; Berhane Ghebrehiwet
Maturation-dependent expression of C1q binding proteins on the cell surface of human monocyte-derived dendritic cells.
International immunopharmacology 2003;3(1):39-51.
2002: Dmitri V Rozanov; Berhane Ghebrehiwet; Boris I Ratnikov; Edward Monosov; Elena I Deryugina; Alex Y Strongin
The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein.
FEBS letters 2002;527(1-3):51-7.
2002: Berhane Ghebrehiwet; Jolyon Jesty; Ellinor I B Peerschke
gC1q-R/p33: structure-function predictions from the crystal structure.
Immunobiology 2002;205(4-5):421-32.
2002: Rajeev Kumar; Ellinor I B Peerschke; Berhane Ghebrehiwet
Zinc induces exposure of hydrophobic sites in the C-terminal domain of gC1q-R/p33.
Molecular immunology 2002;39(1-2):69-75.
2002: K V K Mohan; Berhane Ghebrehiwet; Chintamani D Atreya
The N-terminal conserved domain of rubella virus capsid interacts with the C-terminal region of cellular p32 and overexpression of p32 enhances the viral infectivity.
Virus research 2002;85(2):151-61.
2002: Dmitri V Rozanov; Berhane Ghebrehiwet; Tatiana I Postnova; Andreas Eichinger; Elena I Deryugina; Alex Y Strongin
The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR.
The Journal of biological chemistry 2002;277(11):9318-25.
2002: Kristen S Grace; Richard A Bronson; Berhane Ghebrehiwet
Surface expression of complement receptor gC1q-R/p33 is increased on the plasma membrane of human spermatozoa after capacitation.
Biology of reproduction 2002;66(3):823-9.
2002: Xiaodong Feng; Marcia G Tonnesen; Ellinor I B Peerschke; Berhane Ghebrehiwet
Cooperation of C1q receptors and integrins in C1q-mediated endothelial cell adhesion and spreading.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2441-8.
2001: Carol Anne Ogden; Aimee M deCathelineau; Peter R Hoffmann; Donna L Bratton; Berhane Ghebrehiwet; Valerie A Fadok; Peter M Henson
C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells.
The Journal of experimental medicine 2001;194(6):781-95.
2001: A J Tye; Berhane Ghebrehiwet; Ning Guo; K N Sastry; Billy K C Chow; Ellinor I B Peerschke; Boon L Lim
The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis.
The Journal of biological chemistry 2001;276(20):17069-75.
2001: Judit Szabó; L Cervenák; F D Tóth; Zoltan Prohaszka ; Laura Horváth; Krisztina Kerekes; Zoltán Beck; Attila Bácsi; Anna Erdei; Ellinor I B Peerschke; George Füst; Berhane Ghebrehiwet
Soluble gC1q-R/p33, a cell protein that binds to the globular "heads" of C1q, effectively inhibits the growth of HIV-1 strains in cell cultures.
Clinical immunology (Orlando, Fla.) 2001;99(2):222-31.
2001: Berhane Ghebrehiwet; Boon L Lim; R Kumar; X Feng; Ellinor I B Peerschke
gC1q-R/p33, a member of a new class of multifunctional and multicompartmental cellular proteins, is involved in inflammation and infection.
Immunological reviews 2001;180():65-77.
2001: Ellinor I B Peerschke; Berhane Ghebrehiwet
Human blood platelet gC1qR/p33.
Immunological reviews 2001;180():56-64.
2001: Allen P Kaplan; Kusumam Joseph; Y Shibayama; SR Reddigari; Berhane Ghebrehiwet
Activation of the plasma kinin forming cascade along cell surfaces.
International archives of allergy and immunology 2001;124(1-3):339-42.
2001: Kusumam Joseph; Berhane Ghebrehiwet; Allen P Kaplan
Activation of the kinin-forming cascade on the surface of endothelial cells.
Biological chemistry 2001;382(1):71-5.
2001: Kusumam Joseph; Y Shibayama; Berhane Ghebrehiwet; Allen P Kaplan
Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1.
Thrombosis and haemostasis 2001;85(1):119-24.
2000: Peter Storz; Angelika Hausser; Gisela Link; J Dedio; Berhane Ghebrehiwet; Klaus Pfizenmaier; Franz-Josef Johannes
Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32.
The Journal of biological chemistry 2000;275(32):24601-7.
2000: L Braun; Berhane Ghebrehiwet; Pascale Cossart
gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes.
The EMBO journal 2000;19(7):1458-66.
2000: T Nguyen; Berhane Ghebrehiwet; Ellinor I B Peerschke
Staphylococcus aureus protein A recognizes platelet gC1qR/p33: a novel mechanism for staphylococcal interactions with platelets.
Infection and immunity 2000;68(4):2061-8.
1999: Kusumam Joseph; Y Shibayama; Yoshitaka Nakazawa; Ellinor I B Peerschke; Berhane Ghebrehiwet; Allen P Kaplan
Interaction of factor XII and high molecular weight kininogen with cytokeratin 1 and gC1qR of vascular endothelial cells and with aggregated Abeta protein of Alzheimer's disease.
Immunopharmacology 1999;43(2-3):203-10.
1999: Kusumam Joseph; Berhane Ghebrehiwet; Allen P Kaplan
Cytokeratin 1 and gC1qR mediate high molecular weight kininogen binding to endothelial cells.
Clinical immunology (Orlando, Fla.) 1999;92(3):246-55.
1999: Kusumam Joseph; Yoshitaka Nakazawa; W F Bahou; Berhane Ghebrehiwet; Allen P Kaplan
Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen.
Molecular medicine (Cambridge, Mass.) 1999;5(8):555-63.
1999: W X Guo; Berhane Ghebrehiwet; B Weksler; K Schweitzer; Ellinor I B Peerschke
Up-regulation of endothelial cell binding proteins/receptors for complement component C1q by inflammatory cytokines.
The Journal of laboratory and clinical medicine 1999;133(6):541-50.
1999: PD Lu; D K Galanakis; Berhane Ghebrehiwet; Ellinor I B Peerschke
The receptor for the globular "heads" of C1q, gC1q-R, binds to fibrinogen/fibrin and impairs its polymerization.
Clinical immunology (Orlando, Fla.) 1999;90(3):360-7.
1998: Ellinor I B Peerschke; Berhane Ghebrehiwet
Platelet receptors for the complement component C1q: implications for hemostasis and thrombosis.
Immunobiology 1998;199(2):239-49.
1998: Berhane Ghebrehiwet; Ellinor I B Peerschke
Structure and function of gC1q-R: a multiligand binding cellular protein.
Immunobiology 1998;199(2):225-38.
1998: X Tan; S T Wong; Berhane Ghebrehiwet; D R Storm; Sandra Bordin
Complement C1q inhibits cellular spreading and stimulates adenylyl cyclase activity of fibroblasts.
Clinical immunology and immunopathology 1998;87(2):193-204.
1998: R Bronson; Susan K Bronson; L Oula; W Zhang; Berhane Ghebrehiwet
Detection of complement C1q receptors on human spermatozoa.
Journal of reproductive immunology 1998;38(1):1-14.
1998: Boon L Lim; R A White; G S Hummel; Wilhelm J Schwaeble; N J Lynch; Ellinor I B Peerschke; K B Reid; Berhane Ghebrehiwet
Characterization of the murine gene of gC1qBP, a novel cell protein that binds the globular heads of C1q, vitronectin, high molecular weight kininogen and factor XII.
Gene 1998;209(1-2):229-37.
1998: LE Leigh; Berhane Ghebrehiwet; Timothy Perera; I N Bird; Peter Strong; Uday Kishore; Kenneth B M Reid; Paul Eggleton
C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms.
The Biochemical journal 1998;330 ( Pt 1)():247-54.
1998: Allen P Kaplan; Kusumam Joseph; Y Shibayama; Yoshitaka Nakazawa; Berhane Ghebrehiwet; SR Reddigari; Michael Silverberg
Bradykinin formation. Plasma and tissue pathways and cellular interactions.
Clinical reviews in allergy & immunology 1998;16(4):403-29.
1998: Ellinor I B Peerschke; Jolyon Jesty; K B Reid; Berhane Ghebrehiwet
The soluble recombinant form of a binding protein/receptor for the globular domain of C1q (gC1qR) enhances blood coagulation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1998;9(1):29-37.
1997: Ellinor I B Peerschke; Berhane Ghebrehiwet
C1q augments platelet activation in response to aggregated Ig.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5594-8.
1997: Nicholas J Lynch; Kenneth B M Reid; R H van den Berg; M R Daha; L A Leigh; Berhane Ghebrehiwet; W B Lim; Wilhelm J Schwaeble
Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q.
FEBS letters 1997;418(1-2):111-4.
1997: Berhane Ghebrehiwet; PD Lu; W Zhang; S A Keilbaugh; LE Leigh; Paul Eggleton; Kenneth B M Reid; Ellinor I B Peerschke
Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1429-36.
1997: Zoltan Prohaszka ; J Nemes; T Hidvégi; F D Tóth; Krisztina Kerekes; Anna Erdei; Judit Szabó; E Ujhelyi; Nicole M Thielens; M P Dierich; P Späth; Berhane Ghebrehiwet; H Hampl; J Kiss; Gérard J Arlaud; George Füst
Two parallel routes of the complement-mediated antibody-dependent enhancement of HIV-1 infection.
AIDS (London, England) 1997;11(8):949-58.
1997: K L Peterson; W Zhang; PD Lu; S A Keilbaugh; Ellinor I B Peerschke; Berhane Ghebrehiwet
The C1q-binding cell membrane proteins cC1q-R and gC1q-R are released from activated cells: subcellular distribution and immunochemical characterization.
Clinical immunology and immunopathology 1997;84(1):17-26.
1997: Allen P Kaplan; Kusumam Joseph; Y Shibayama; SR Reddigari; Berhane Ghebrehiwet; Michael Silverberg
The intrinsic coagulation/kinin-forming cascade: assembly in plasma and cell surfaces in inflammation.
Advances in immunology 1997;66():225-72.
1997: Ning Guo; S Weremowicz; N Lynch; Boon L Lim; Wilhelm J Schwaeble; Ellinor I B Peerschke; C C Morton; K B Reid; Berhane Ghebrehiwet; K N Sastry
Assignment of C1QBP encoding the C1q globular domain binding protein (gC1q-R) to human chromosome 17 band p13.3 by in situ hybridization.
Cytogenetics and cell genetics 1997;77(3-4):283-4.
1996: E I Peerschke; Susan Smyth; E I Teng; M Dalzell; Berhane Ghebrehiwet
Human umbilical vein endothelial cells possess binding sites for the globular domain of C1q.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):4154-8.
1996: Boon L Lim; Kenneth B M Reid; Berhane Ghebrehiwet; Ellinor I B Peerschke; L A Leigh; K T Preissner
The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor.
The Journal of biological chemistry 1996;271(43):26739-44.
1996: Berhane Ghebrehiwet; P D Lu; W Zhang; Boon L Lim; Paul Eggleton; L E Leigh; Kenneth B M Reid; Ellinor I B Peerschke
Identification of functional domains on gC1Q-R, a cell surface protein that binds to the globular "heads" of C1Q, using monoclonal antibodies and synthetic peptides.
Hybridoma 1996;15(5):333-42.
1996: Piotr Kuna; M Iyer; E I Peerschke; A P Kaplan; K B Reid; Berhane Ghebrehiwet
Human C1q induces eosinophil migration.
Clinical immunology and immunopathology 1996;81(1):48-54.
1996: Kusumam Joseph; Berhane Ghebrehiwet; Ellinor I B Peerschke; Kenneth B M Reid; Allen P Kaplan
Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R).
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8552-7.
1995: Berhane Ghebrehiwet; Richard R Kew; Barry L Gruber; Mary J Marchese; Ellinor I B Peerschke; Kenneth B M Reid
Murine mast cells express two types of C1q receptors that are involved in the induction of chemotaxis and chemokinesis.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2614-9.
1995: Paul Eggleton; Berhane Ghebrehiwet; K N Sastry; J P Coburn; K S Zaner; Kenneth B M Reid; Alfred I Tauber
Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R.
The Journal of clinical investigation 1995;95(4):1569-78.
1994: E I Peerschke; Berhane Ghebrehiwet
Platelet membrane receptors for the complement component C1q.
Seminars in hematology 1994;31(4):320-8.
1994: Paul Eggleton; Berhane Ghebrehiwet; J P Coburn; K N Sastry; K S Zaner; Alfred I Tauber
Characterization of the human neutrophil C1q receptor and functional effects of free ligand on activated neutrophils.
Blood 1994;84(5):1640-9.
1994: Paul Eggleton; T S Lieu; E G Zappi; K Sastry; J Coburn; K S Zaner; Richard D Sontheimer; J Donald Capra; Berhane Ghebrehiwet; Alfred I Tauber
Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein.
Clinical immunology and immunopathology 1994;72(3):405-9.
1994: A Chen; S Gaddipati; Y Hong; D J Volkman; Ellinor I B Peerschke; Berhane Ghebrehiwet
Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1430-40.
1994: Ellinor I B Peerschke; Kenneth B M Reid; Berhane Ghebrehiwet
Identification of a novel 33-kDa C1q-binding site on human blood platelets.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5896-901.
1994: Berhane Ghebrehiwet; Boon L Lim; Ellinor I B Peerschke; Antony C Willis; Kenneth B M Reid
Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q.
The Journal of experimental medicine 1994;179(6):1809-21.
1994: D K Galanakis; Berhane Ghebrehiwet
A unique property of a plasma proteoglycan, the C1q inhibitor. An anticoagulant state resulting from its binding to fibrinogen.
The Journal of clinical investigation 1994;93(1):303-10.
1993: Berhane Ghebrehiwet; Ellinor I B Peerschke
The C1q-R participates in immunoregulation and signal transduction.
Behring Institute Mitteilungen 1993;(93):236-40.
1993: Berhane Ghebrehiwet; D K Galanakis
C1q inhibitor (chondroitin-4-sulfate proteoglycan): structure and function.
Behring Institute Mitteilungen 1993;(93):214-23.
1993: E I Peerschke; K B Reid; Berhane Ghebrehiwet
Platelet activation by C1q results in the induction of alpha IIb/beta 3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity.
The Journal of experimental medicine 1993;178(2):579-87.
1993: E I Peerschke; R Malhotra; Berhane Ghebrehiwet; Kenneth B M Reid; Antony C Willis; Robert B Sim
Isolation of a human endothelial cell C1q receptor (C1qR).
Journal of leukocyte biology 1993;53(2):179-84.
1992: Berhane Ghebrehiwet; Ellinor I B Peerschke; Y Hong; P Munoz; P D Gorevic
Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV.
Journal of leukocyte biology 1992;51(6):546-56.
1992: Y Hong; C W Kim; Berhane Ghebrehiwet
Trichinella spiralis: activation of complement by infective larvae, adults, and newborn larvae.
Experimental parasitology 1992;74(3):290-9.
1992: Sandra Bordin; M Smith; Berhane Ghebrehiwet; D Oda; Roy C Page
Smooth muscle and epithelial cells express specific binding sites for the C1q component of complement.
Clinical immunology and immunopathology 1992;63(1):51-7.
1992: E I Peerschke; Berhane Ghebrehiwet
Platelet interactions with C1q in whole blood and in the presence of immune complexes or aggregated IgG.
Clinical immunology and immunopathology 1992;63(1):45-50.
1992: Y Q Hong; Berhane Ghebrehiwet
Effect of Pseudomonas aeruginosa elastase and alkaline protease on serum complement and isolated components C1q and C3.
Clinical immunology and immunopathology 1992;62(2):133-8.
1992: E I Peerschke; Berhane Ghebrehiwet
Biochemical and functional comparison of platelet and raji cell clq receptors.
Platelets 1992;3(4):189-93.
1991: Francesco Fusi; Richard A Bronson; Y Hong; Berhane Ghebrehiwet
Complement component C1q and its receptor are involved in the interaction of human sperm with zona-free hamster eggs.
Molecular reproduction and development 1991;29(2):180-8.
1990: E I Peerschke; Berhane Ghebrehiwet
Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(9):2984-8.
1990: Sandra Bordin; Berhane Ghebrehiwet; Roy C Page
Participation of C1q and its receptor in adherence of human diploid fibroblast.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2520-6.
1990: E I Peerschke; Berhane Ghebrehiwet
Modulation of platelet responses to collagen by Clq receptors.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(1):221-5.
1990: Berhane Ghebrehiwet; G S Habicht; G Beck
Interaction of C1q with its receptor on cultured cell lines induces an anti-proliferative response.
Clinical immunology and immunopathology 1990;54(1):148-60.
1989: Berhane Ghebrehiwet
Functions associated with the C1q receptor.
Behring Institute Mitteilungen 1989;(84):204-15.
1989: Allen P Kaplan; M Silverberg; Berhane Ghebrehiwet; P Atkins; B Zweiman
Pathways of kinin formation and role in allergic diseases.
Clinical immunology and immunopathology 1989;50(1 Pt 2):S41-51.
1989: A P Kaplan; M Silverberg; Berhane Ghebrehiwet; P Atkins; B Zweiman
The kallikrein-kinin system in inflammation.
Advances in experimental medicine and biology 1989;247A():125-36.
1988: B P Randazzo; H B Fleit; Allen P Kaplan; Berhane Ghebrehiwet
Expression of functional cell surface C1-inactivator by U937 cells.
Clinical immunology and immunopathology 1988;49(3):463-77.
1988: E I Peerschke; Berhane Ghebrehiwet
Identification and partial characterization of human platelet C1q binding sites.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3505-11.
1988: Berhane Ghebrehiwet; S Bossone; A Erdei; Kenneth B M Reid
Reversible biotinylation of C1q with a cleavable biotinyl derivative. Application in C1q receptor (C1qR) purification.
Journal of immunological methods 1988;110(2):251-60.
1987: Richard R Kew; Berhane Ghebrehiwet; A Janoff
Characterization of the third component of complement (C3) after activation by cigarette smoke.
Clinical immunology and immunopathology 1987;44(2):248-58.
1987: G S Habicht; G Beck; Berhane Ghebrehiwet
C1q inhibits the expression of B lymphoblastoid cell line interleukin 1 (IL 1).
Journal of immunology (Baltimore, Md. : 1950) 1987;138(8):2593-7.
1987: Richard R Kew; Berhane Ghebrehiwet; A Janoff
The fifth component of complement (C5) is necessary for maximal pulmonary leukocytosis in mice chronically exposed to cigarette smoke.
Clinical immunology and immunopathology 1987;43(1):73-81.
1987: E I Peerschke; Berhane Ghebrehiwet
Human blood platelets possess specific binding sites for C1q.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(5):1537-41.
1987: Berhane Ghebrehiwet
C1q receptor.
Methods in enzymology 1987;150():558-78.
1986: Berhane Ghebrehiwet
Production and characterization of a murine monoclonal IgM antibody to human C1q receptor (C1qR).
Journal of immunology (Baltimore, Md. : 1950) 1986;137(2):618-24.
1986: Richard R Kew; Berhane Ghebrehiwet; A Janoff
The role of complement in cigarette smoke-induced chemotactic activity of lung fluids.
The American review of respiratory disease 1986;133(3):478-81.
1986: A P Kaplan; M Silverberg; Berhane Ghebrehiwet
The intrinsic coagulation/kinin pathway--the classical complement pathway and their interactions.
Advances in experimental medicine and biology 1986;198 Pt B():11-25.
1985: B P Randazzo; R J Dattwyler; Allen P Kaplan; Berhane Ghebrehiwet
Synthesis of C1 inhibitor (C1-INA) by a human monocyte-like cell line, U937.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(2):1313-9.
1985: Richard R Kew; Berhane Ghebrehiwet; A Janoff
Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement.
The Journal of clinical investigation 1985;75(3):1000-7.
1984: Berhane Ghebrehiwet; L Silvestri; C McDevitt
Identification of the Raji cell membrane-derived C1q inhibitor as a receptor for human C1q. Purification and immunochemical characterization.
The Journal of experimental medicine 1984;160(5):1375-89.
1984: Berhane Ghebrehiwet; B P Randazzo; Allen P Kaplan
Studies of complement autoactivatability in hereditary angioedema: direct relationship to functional C-1-INA and the effect of classical pathway activators.
Clinical immunology and immunopathology 1984;32(1):101-10.
1984: Berhane Ghebrehiwet
The release of lysosomal enzymes from human polymorphonuclear leukocytes by human C3e.
Clinical immunology and immunopathology 1984;30(2):321-9.
1984: A D Rosen; M I Hamburger; Berhane Ghebrehiwet; G Gerardi
Visual evoked potentials altered by serum IgG of patients with multiple sclerosis.
Neurology 1984;34(1):89-91.
1983: T R Fields; E N Gerardi; Berhane Ghebrehiwet; R S Bennett; T J Lawley; R P Hall; Paul H Plotz; J R Karsh; M M Frank; M I Hamburger
Reticuloendothelial system fc receptor function in rheumatoid arthritis.
The Journal of rheumatology 1983;10(4):550-7.
1983: T Fields; Berhane Ghebrehiwet; A P Kaplan
Kinin formation in hereditary angioedema plasma: evidence against kinin derivation from C2 and in support of "spontaneous" formation of bradykinin.
The Journal of allergy and clinical immunology 1983;72(1):54-60.
1983: Berhane Ghebrehiwet; B P Randazzo; J T Dunn; M Silverberg; Allen P Kaplan
Mechanisms of activation of the classical pathway of complement by Hageman factor fragment.
The Journal of clinical investigation 1983;71(5):1450-6.
1983: T R Fields; S B Abramson; G Weissmann; A P Kaplan; Berhane Ghebrehiwet
Activation of the alternative pathway of complement by monosodium urate crystals.
Clinical immunology and immunopathology 1983;26(2):249-57.
1982: Berhane Ghebrehiwet; M Hamburger
Purification and partial characterization of a C1q inhibitor from the membranes of human peripheral blood lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(1):157-62.
1982: A P Kaplan; M Silverberg; J T Dunn; Berhane Ghebrehiwet
Interaction of the clotting, kinin-forming, complement, and fibrinolytic pathways in inflammation.
Annals of the New York Academy of Sciences 1982;389():25-38.
1981: A P Kaplan; Berhane Ghebrehiwet; M Silverberg; J E Sealey
The intrinsic coagulation-kinin pathway, complement cascades, plasma renin-angiotensin system, and their interrelationships.
Critical reviews in immunology 1981;3(1):75-93.
1981: Berhane Ghebrehiwet
C1q inhibitor (C1qINH): functional properties and possible relationship to a lymphocyte membrane-associated C1q precipitin.
Journal of immunology (Baltimore, Md. : 1950) 1981;126(5):1837-42.
1981: Berhane Ghebrehiwet; M Silverberg; A P Kaplan
Activation of the classical pathway of complement by Hageman factor fragment.
The Journal of experimental medicine 1981;153(3):665-76.
1979: Berhane Ghebrehiwet; R G Medicus; H J Müller-Eberhard
Potentiation of antiboty-dependent cell-mediated cytotoxicity by target cell-bound C3b.
Journal of immunology (Baltimore, Md. : 1950) 1979;123(3):1285-8.
1979: Berhane Ghebrehiwet; H J Müller-Eberhard
C3e: an acidic fragment of human C3 with leukocytosis-inducing activity.
Journal of immunology (Baltimore, Md. : 1950) 1979;123(2):616-21.
1978: Berhane Ghebrehiwet; H J Müller-Eberhard
Lysis of C1Q-coated chicken erythrocytes by human lymphoblastoid cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1978;120(1):27-32.