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Anna Ghelli

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Anna Ghelli; Luisa Iommarini; Ivana Kurelac; Alessandra Marchesini; Andrea Martinuzzi; Anna Maria Porcelli; Maria Antonietta Calvaruso; Fevzi Daldal; Vera De Nardo; Giuseppe Gasparre; Nur Selamoglu; Concetta V Tropeano; John Vissing; Flemming Wibrand; Claudia Zanna; Michela Rugolo
The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes.
Giuseppe Gasparre; Anna Ghelli; Luisa Iommarini; Ivana Kurelac; Pier-Luigi Lollini; Patrizia Nanni; Giordano Nicoletti; Christine M Betts; Mariantonietta Capristo; Valerio Carelli; Claudio Ceccarelli; Carla De Giovanni; Giovanni Romeo; Michela Rugolo; Katia Scotlandi; Anna Maria Porcelli
A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.
Valerio Carelli; Simone Schimpf; Nico Fuhrmann; Maria Lucia Valentino; Claudia Zanna; Luisa Iommarini; Monika Papke; Simone Schaich; Sabine Tippmann; Britta Baumann; Piero Barboni; Lora Longanesi; Michela Rugolo; Anna Ghelli; Marcel Alavi; Richard J Youle; Laura Bucchi; Rosanna Carroccia; Maria Pia Giannoccaro; Caterina Tonon; Raffaele Lodi; Giovanna Cenacchi; Pasquale Montagna; Rocco Liguori; Bernd Wissinger
A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16.

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All Publications

2013: Anna Ghelli; Luisa Iommarini; Ivana Kurelac; Alessandra Marchesini; Andrea Martinuzzi; Anna Maria Porcelli; Maria Antonietta Calvaruso; Fevzi Daldal; Vera De Nardo; Giuseppe Gasparre; Nur Selamoglu; Concetta V Tropeano; John Vissing; Flemming Wibrand; Claudia Zanna; Michela Rugolo
The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes.
Human molecular genetics 2013;22(11):2141-51.
2011: Giuseppe Gasparre; Anna Ghelli; Luisa Iommarini; Ivana Kurelac; Pier-Luigi Lollini; Patrizia Nanni; Giordano Nicoletti; Christine M Betts; Mariantonietta Capristo; Valerio Carelli; Claudio Ceccarelli; Carla De Giovanni; Giovanni Romeo; Michela Rugolo; Katia Scotlandi; Anna Maria Porcelli
A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.
Cancer research 2011;71(19):6220-9.
2011: Valerio Carelli; Simone Schimpf; Nico Fuhrmann; Maria Lucia Valentino; Claudia Zanna; Luisa Iommarini; Monika Papke; Simone Schaich; Sabine Tippmann; Britta Baumann; Piero Barboni; Lora Longanesi; Michela Rugolo; Anna Ghelli; Marcel Alavi; Richard J Youle; Laura Bucchi; Rosanna Carroccia; Maria Pia Giannoccaro; Caterina Tonon; Raffaele Lodi; Giovanna Cenacchi; Pasquale Montagna; Rocco Liguori; Bernd Wissinger
A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16.
Human molecular genetics 2011;20(10):1893-905.
2011: D Gonzalez-Halphen; Luisa Iommarini; Valerio Carelli; Anna Ghelli; Mauro Degli Esposti
Mitochondrial complex I and cell death: a semi-automatic shotgun model.
Cell death & disease 2011;2():e222.
2011: Carla Giordano; monica montopoli; Elena Perli; Maurizia Orlandi; Marianna Fantin; Fred N Ross-Cisneros; Laura Caparrotta; Andrea Martinuzzi; Eugenio Ragazzi; Anna Ghelli; Alfredo Sadun; Giulia d'Amati; Valerio Carelli
Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy.
Brain : a journal of neurology 2011;134(Pt 1):220-34.
2010: Anna Maria Porcelli; Anna Ghelli; Claudio Ceccarelli; Martin Lang; Giovanna Cenacchi; Mariantonietta Capristo; Lucia Fiammetta Pennisi; Isabella Morra; Enrica Ciccarelli; Antonio Melcarne; Anna Bartoletti-Stella; Nunzio Salfi; Giovanni Tallini; Andrea Martinuzzi; Valerio Carelli; Marcella Attimonelli; Michela Rugolo; Giovanni Romeo; Giuseppe Gasparre
The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization.
Human molecular genetics 2010;19(6):1019-32.
2009: Giuseppe Gasparre; Luisa Iommarini; Anna Maria Porcelli; Martin Lang; Gian Gaetano Ferri; Ivana Kurelac; Roberta Zuntini; Elisa Mariani; Lucia Fiammetta Pennisi; Ernesto Pasquini; Gianandrea Pasquinelli; Anna Ghelli; Elena Bonora; Claudio Ceccarelli; Michela Rugolo; Nunzio Salfi; Giovanni Romeo; Valerio Carelli
An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells.
Human mutation 2009;30(3):391-6.
2009: Anna Maria Porcelli; Alessia Angelin; Anna Ghelli; Elisa Mariani; Andrea Martinuzzi; Valerio Carelli; Valeria Petronilli; Paolo Bernardi; Michela Rugolo
Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels.
The Journal of biological chemistry 2009;284(4):2045-52.
2009: Anna Ghelli; Anna Maria Porcelli; Claudia Zanna; Sara Vidoni; Stefano Mattioli; Anna Barbieri; Luisa Iommarini; Maria Pala; Alessandro Achilli; Antonio Torroni; Michela Rugolo; Valerio Carelli
The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity.
PloS one 2009;4(11):e7922.
2008: Anna Maria Porcelli; Anna Ghelli; Luisa Iommarini; E Mariani; M Hoque; Claudia Zanna; Giuseppe Gasparre; Michela Rugolo
The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.
Cellular and molecular life sciences : CMLS 2008;65(18):2943-51.
2008: Anna Ghelli; Anna Maria Porcelli; Claudia Zanna; Andrea Martinuzzi; Valerio Carelli; Michela Rugolo
Protection against oxidant-induced apoptosis by exogenous glutathione in Leber hereditary optic neuropathy cybrids.
Investigative ophthalmology & visual science 2008;49(2):671-6.
2008: Claudia Zanna; Anna Ghelli; Anna Maria Porcelli; Mariusz Karbowski; Richard J Youle; Simone Schimpf; Bernd Wissinger; Marcello Pinti; Andrea Cossarizza; Sara Vidoni; Maria Lucia Valentino; Michela Rugolo; Valerio Carelli
OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.
Brain : a journal of neurology 2008;131(Pt 2):352-67.
2007: Cristina Angeloni; Tullia Maraldi; Anna Ghelli; Michela Rugolo; Emanuela Leoncini; Gabriele Hakim; Silvana Hrelia
Green tea modulates alpha(1)-adrenergic stimulated glucose transport in cultured rat cardiomyocytes.
Journal of agricultural and food chemistry 2007;55(18):7553-8.
2007: Giuseppe Gasparre; Anna Maria Porcelli; Elena Bonora; Lucia Fiammetta Pennisi; Matteo Toller; Luisa Iommarini; Anna Ghelli; Massimo Moretti; Christine M Betts; Giuseppe Nicola Martinelli; Alberto Rinaldi Ceroni; Francesco Curcio; Valerio Carelli; Michela Rugolo; Giovanni Tallini; Giovanni Romeo
Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):9001-6.
2006: Elena Bonora; Anna Maria Porcelli; Giuseppe Gasparre; Annalisa Biondi; Anna Ghelli; Valerio Carelli; Alessandra Baracca; Giovanni Tallini; Andrea Martinuzzi; Giorgio Lenaz; Michela Rugolo; Giovanni Romeo
Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.
Cancer research 2006;66(12):6087-96.
2005: Claudia Zanna; Anna Ghelli; Anna Maria Porcelli; Andrea Martinuzzi; Valerio Carelli; Michela Rugolo
Caspase-independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G.
Apoptosis : an international journal on programmed cell death 2005;10(5):997-1007.
2005: Anna Maria Porcelli; Anna Ghelli; Claudia Zanna; Paolo Pinton; Rosario Rizzuto; Michela Rugolo
pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant.
Biochemical and biophysical research communications 2005;326(4):799-804.
2004: Maria Lucia Valentino; Piero Barboni; Anna Ghelli; Lauro Bucchi; Chiara Rengo; Alessandro Achilli; Antonio Torroni; Alessandra Lugaresi; Raffaele Lodi; Bruno Barbiroli; Mariateresa Dotti; Antonio Federico; Agostino Baruzzi; Valerio Carelli
The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy.
Annals of neurology 2004;56(5):631-41.
2004: Valerio Carelli; Michela Rugolo; Gianluca Sgarbi; Anna Ghelli; Claudia Zanna; Alessandra Baracca; Giorgio Lenaz; Eleonora Napoli; Andrea Martinuzzi; Giancarlo Solaini
Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration.
Biochimica et biophysica acta 2004;1658(1-2):172-9.
2004: Anna Maria Porcelli; Anna Ghelli; Claudia Zanna; Pierluigi Valente; Stefano Ferroni; Michela Rugolo
Apoptosis induced by staurosporine in ECV304 cells requires cell shrinkage and upregulation of Cl- conductance.
Cell death and differentiation 2004;11(6):655-62.
2003: Anna Maria Porcelli; Anna Ghelli; Claudia Zanna; Pierluigi Valente; Stefano Ferroni; Michela Rugolo
Staurosporine induces apoptotic volume decrease (AVD) in ECV304 cells.
Annals of the New York Academy of Sciences 2003;1010():342-6.
2003: Claudia Zanna; Anna Ghelli; Anna Maria Porcelli; Valerio Carelli; Andrea Martinuzzi; Michela Rugolo
Apoptotic cell death of cybrid cells bearing Leber's hereditary optic neuropathy mutations is caspase independent.
Annals of the New York Academy of Sciences 2003;1010():213-7.
2003: Anna Ghelli; Claudia Zanna; Anna Maria Porcelli; Anthony H V Schapira; Andrea Martinuzzi; Valerio Carelli; Michela Rugolo
Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium.
The Journal of biological chemistry 2003;278(6):4145-50.
2002: Anna Ghelli; Anna Maria Porcelli; Annalisa Facchini; Silvana Hrelia; Flavio Flamigni; Michela Rugolo
Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta.
The Biochemical journal 2002;366(Pt 1):187-93.
2002: Anna Ghelli; Anna Maria Porcelli; Claudia Zanna; Michela Rugolo
7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells.
Archives of biochemistry and biophysics 2002;402(2):208-17.
2002: Anna Maria Porcelli; Anna Ghelli; Silvana Hrelia; Michela Rugolo
Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells.
Cellular signalling 2002;14(1):75-81.
1999: Anna Maria Porcelli; Anna Ghelli; T Mastrocola; Michela Rugolo
Arachidonic acid release by ionomycin and phorbol ester is similar in C127 epithelial cells expressing wild-type or mutated (delta F508) cystic fibrosis transmembrane conductance regulator.
Cellular and molecular life sciences : CMLS 1999;56(1-2):167-73.
1999: Mauro Degli Esposti; Anna Ghelli
Ubiquinone and inhibitor sites in complex I: one, two or three?
Biochemical Society transactions 1999;27(4):606-9.
1999: Valerio Carelli; Anna Ghelli; Lauro Bucchi; Pasquale Montagna; Anna Maria De Negri; Vincenzo Leuzzi; Carla Carducci; Giorgio Lenaz; Elio Lugaresi; M Degli Esposti
Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy.
Annals of neurology 1999;45(3):320-8.
1997: Alessandra Baracca; Lauro Bucchi; Anna Ghelli; Giorgio Lenaz
Protonophoric activity of NADH coenzyme Q reductase and ATP synthase in coupled submitochondrial particles from horse platelets.
Biochemical and biophysical research communications 1997;235(3):469-73.
1997: Valerio Carelli; Anna Ghelli; Marina Ratta; E Bacchilega; Simonetta Sangiorgi; R Mancini; Vincenzo Leuzzi; Pietro Cortelli; Pasquale Montagna; Elio Lugaresi; M Degli Esposti
Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype.
Neurology 1997;48(6):1623-32.
1997: Anna Ghelli; B Benelli; Mauro Degli Esposti
Measurement of the membrane potential generated by complex I in submitochondrial particles.
Journal of biochemistry 1997;121(4):746-55.
1997: L Helfenbaum; A Ngo; Anna Ghelli; A W Linnane; M Degli Esposti
Proton pumping of mitochondrial complex I: differential activation by analogs of ubiquinone.
Journal of bioenergetics and biomembranes 1997;29(1):71-80.
1997: Anna Ghelli; M Degli Esposti; Valerio Carelli; Giorgio Lenaz
Changes in mitochondrial complex I activity and coenzyme Q binding site in Leber's hereditary optic neuropathy (LHON).
Molecular aspects of medicine 1997;18 Suppl():S263-7.
1996: Mauro Degli Esposti; A Ngo; Anna Ghelli; B Benelli; Valerio Carelli; H McLennan; Anthony Linnane
The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria.
Archives of biochemistry and biophysics 1996;330(2):395-400.
1996: Milena Merlo Pich; Carla Bovina; Gabriella Formiggini; G G Cometti; Anna Ghelli; Giovanna Parenti Castelli; Maria Luisa Genova; M Marchetti; S Semeraro; Giorgio Lenaz
Inhibitor sensitivity of respiratory complex I in human platelets: a possible biomarker of ageing.
FEBS letters 1996;380(1-2):176-8.
1996: M Degli Esposti; A Ngo; G L McMullen; Anna Ghelli; F Sparla; B Benelli; Marina Ratta; Anthony Linnane
The specificity of mitochondrial complex I for ubiquinones.
The Biochemical journal 1996;313 ( Pt 1)():327-34.
1995: Aldo Andreani; M Rambaldi; Alberto Leoni; Alessandra Locatelli; Anna Ghelli; Marina Ratta; B Benelli; M Degli Esposti
Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase.
Journal of medicinal chemistry 1995;38(7):1090-7.
1994: M Degli Esposti; Valerio Carelli; Anna Ghelli; Marina Ratta; Massimo Crimi; S Sangiorgi; Pasquale Montagna; Giorgio Lenaz; Elio Lugaresi; Pietro Cortelli
Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy.
FEBS letters 1994;352(3):375-9.
1994: M Degli Esposti; Anna Ghelli
The mechanism of proton and electron transport in mitochondrial complex I.
Biochimica et biophysica acta 1994;1187(2):116-20.
1994: M Degli Esposti; Anna Ghelli; Marina Ratta; Diego Cortes; Ernesto Estornell
Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).
The Biochemical journal 1994;301 ( Pt 1)():161-7.
1994: Aldo Andreani; M Rambaldi; Alessandra Locatelli; Alberto Leoni; Anna Ghelli; M Degli Esposti
Thienylvinylindoles as inhibitors of mitochondrial NADH dehydrogenase.
Pharmaceutica acta Helvetiae 1994;69(1):15-20.
1994: M Degli Esposti; Massimo Crimi; Anna Ghelli
Natural variation in the potency and binding sites of mitochondrial quinone-like inhibitors.
Biochemical Society transactions 1994;22(1):209-13.
1993: Mauro Degli Esposti; S De Vries; Massimo Crimi; Anna Ghelli; T Patarnello; A Meyer
Mitochondrial cytochrome b: evolution and structure of the protein.
Biochimica et biophysica acta 1993;1143(3):243-71.
1993: M Degli Esposti; Anna Ghelli; Massimo Crimi; Ernesto Estornell; Romana Fato; Giorgio Lenaz
Complex I and complex III of mitochondria have common inhibitors acting as ubiquinone antagonists.
Biochemical and biophysical research communications 1993;190(3):1090-6.
1992: Anna Ghelli; Massimo Crimi; S Orsini; L Gradoni; M Zannotti; Giorgio Lenaz; M Degli Esposti
Cytochrome b of protozoan mitochondria: relationships between function and structure.
Comparative biochemistry and physiology. B, Comparative biochemistry 1992;103(2):329-38.
1992: M Degli Esposti; Anna Ghelli; Massimo Crimi; Alessandra Baracca; Giancarlo Solaini; T Tron; A Meyer
Cytochrome b of fish mitochondria is strongly resistant to funiculosin, a powerful inhibitor of respiration.
Archives of biochemistry and biophysics 1992;295(1):198-204.
1990: M Degli Esposti; Anna Ghelli; G Butler; Marina Roberti; A Mustich; Palmiro Cantatore
The cytochrome b of the sea urchin Paracentrotus lividus is naturally resistant to myxothiazol and mucidin.
FEBS letters 1990;263(2):245-7.
1989: M Degli Esposti; Anna Ghelli; R Luchetti; Massimo Crimi; Giorgio Lenaz
New approaches to the prediction of the folding of membrane proteins with redox function.
The Italian journal of biochemistry 1989;38(1):1-22.