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Ermanno Gherardi

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Sameer A Greenall; Luisa Iamele; Jacqueline F Donoghue; Ermanno Gherardi; Qian Li; Zhanqi Liu; Roger Murphy; Andrew M Scott; Angela A Vitali; Terrance G Johns
Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.
Mark Youles; Oliver Holmes; Maxim V Petoukhov; Merel A Nessen; Simona Stivala; Dmitri I Svergun; Ermanno Gherardi
Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist.
Krista R Catlow; Jon A Deakin; Zheng Wei; Maryse DELEHEDDE; David G Fernig; Ermanno Gherardi; John T Gallagher; Mauro Pavão; Malcolm Lyon
Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density.

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2012: Sameer A Greenall; Luisa Iamele; Jacqueline F Donoghue; Ermanno Gherardi; Qian Li; Zhanqi Liu; Roger Murphy; Andrew M Scott; Angela A Vitali; Terrance G Johns
Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.
PloS one 2012;7(4):e34658.
2008: Mark Youles; Oliver Holmes; Maxim V Petoukhov; Merel A Nessen; Simona Stivala; Dmitri I Svergun; Ermanno Gherardi
Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist.
Journal of molecular biology 2008;377(3):616-22.
2008: Krista R Catlow; Jon A Deakin; Zheng Wei; Maryse DELEHEDDE; David G Fernig; Ermanno Gherardi; John T Gallagher; Mauro Pavão; Malcolm Lyon
Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density.
The Journal of biological chemistry 2008;283(9):5235-48.
2007: Neda Farahi; Andrew S Cowburn; Paul D Upton; John Deighton; Anastasia Sobolewski; Ermanno Gherardi; Nicholas W Morrell; Edwin R Chilvers
Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1264-73.
2007: O Holmes; S Pillozzi; Jon A Deakin; F Carafoli; L Kemp; P Jonathan G Butler; Malcolm Lyon; Ermanno Gherardi
Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains.
Journal of molecular biology 2007;367(2):395-408.
2006: L E Kemp; B Mulloy; Ermanno Gherardi
Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.
Biochemical Society transactions 2006;34(Pt 3):414-7.
2006: Ermanno Gherardi; Sara Sandin; Maxim V Petoukhov; John Finch; Mark E Youles; Lars-Göran Ofverstedt; Ricardo N Miguel; Tom L Blundell; George Vande Woude; Ulf Skoglund; Dmitri I Svergun
Structural basis of hepatocyte growth factor/scatter factor and MET signalling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4046-51.
2006: Heather McKinnon; Ermanno Gherardi; Michael Reidy; David Bowyer
Hepatocyte growth factor/scatter factor and MET are involved in arterial repair and atherogenesis.
The American journal of pathology 2006;168(1):340-8.
2005: Federico Carafoli; Dimitri Y Chirgadze; Tom L Blundell; Ermanno Gherardi
Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein.
The FEBS journal 2005;272(22):5799-807.
2004: Malcolm Lyon; Jon A Deakin; Daniel Lietha; Ermanno Gherardi; John T Gallagher
The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides.
The Journal of biological chemistry 2004;279(42):43560-7.
2004: Damon Bevan; Ermanno Gherardi; Tai-Ping D Fan; Dylan Edwards; Richard Warn
Diverse and potent activities of HGF/SF in skin wound repair.
The Journal of pathology 2004;203(3):831-8.
2004: Shiladitya Sengupta; Lynda A Sellers; Ermanno Gherardi; Ram Sasisekharan; Tai-Ping D Fan
Nitric oxide modulates hepatocyte growth factor/scatter factor-induced angiogenesis.
Angiogenesis 2004;7(4):285-94.
2003: Carmen Birchmeier; Walter Birchmeier; Ermanno Gherardi; George Vande Woude
Met, metastasis, motility and more.
Nature reviews. Molecular cell biology 2003;4(12):915-25.
2003: shiladitya sengupta; Lynda A Sellers; Tereza Cindrova; Jeremy N Skepper; Ermanno Gherardi; Ram Sasisekharan; Tai-Ping D Fan
Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis.
Cancer research 2003;63(23):8351-9.
2003: Ermanno Gherardi; Mark E Youles; Ricardo N Miguel; Tom L Blundell; Luisa Iamele; Julian Gough; Abhishek Bandyopadhyay; Guido Hartmann; P Jonathan G Butler
Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12039-44.
2003: shiladitya sengupta; Lynda A Sellers; Rung-chi Li; Ermanno Gherardi; Ganlin Zhao; Nicki Watson; Ram Sasisekharan; Tai-Ping D Fan
Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis.
Circulation 2003;107(23):2955-61.
2003: shiladitya sengupta; Ermanno Gherardi; Lynda A Sellers; Jeanette M Wood; Ram Sasisekharan; Tai-Ping D Fan
Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):69-75.
2002: Keiichi Watanabe; Dimitri Y Chirgadze; Daniel Lietha; Hugo de Jonge; Tom L Blundell; Ermanno Gherardi
A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping.
Journal of molecular biology 2002;319(2):283-8.
2001: Daniel Lietha; Dimitri Y Chirgadze; B Mulloy; Tom L Blundell; Ermanno Gherardi
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.
The EMBO journal 2001;20(20):5543-55.
1999: M Zaccolo; Ermanno Gherardi
The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase.
Journal of molecular biology 1999;285(2):775-83.
1999: Dimitri Y Chirgadze; JP Hepple; H Zhou; R A Byrd; Tom L Blundell; Ermanno Gherardi
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
Nature structural biology 1999;6(1):72-9.
1998: Carmen Birchmeier; Ermanno Gherardi
Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase.
Trends in cell biology 1998;8(10):404-10.
1998: Dimitri Y Chirgadze; JP Hepple; R A Byrd; R Sowdhamini; Tom L Blundell; Ermanno Gherardi
Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation.
FEBS letters 1998;430(1-2):126-9.
1998: Guido Hartmann; TD Prospero; Volker Brinkmann; Cemil Ozcelik; G Winter; JP Hepple; S Batley; F Bladt; Martin Sachs; Carmen Birchmeier; Walter Birchmeier; Ermanno Gherardi; O Ozcelik
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo.
Current biology : CB 1998;8(3):125-34.
1997: M Zaccolo; A P Griffiths; TD Prospero; G Winter; Ermanno Gherardi
Dimerization of Fab fragments enables ready screening of phage antibodies that affect hepatocyte growth factor/scatter factor activity on target cells.
European journal of immunology 1997;27(3):618-23.
1997: Ermanno Gherardi; Guido Hartmann; JP Hepple; Dimitri Y Chirgadze; N Srinivasan; Tom L Blundell
Domain structure of hepatocyte growth factor/scatter factor (HGF/SF).
Ciba Foundation symposium 1997;212():84-93; discussion 93-104.
1996: M Zaccolo; D M Williams; D M Brown; Ermanno Gherardi
An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues.
Journal of molecular biology 1996;255(4):589-603.
1996: E Andermarcher; M A Surani; Ermanno Gherardi
Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis.
Developmental genetics 1996;18(3):254-66.
1995: Ian M Tomlinson; J P Cox; Ermanno Gherardi; Arthur M Lesk; Cyrus Chothia
The structural repertoire of the human V kappa domain.
The EMBO journal 1995;14(18):4628-38.
1995: C D Moorby; M Stoker; Ermanno Gherardi
HGF/SF inhibits junctional communication.
Experimental cell research 1995;219(2):657-63.
1995: AC Streit; Claudio D Stern; C Théry; Grenham Ireland; Samuel A J R Aparicio; M J Sharpe; Ermanno Gherardi
A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation.
Development (Cambridge, England) 1995;121(3):813-24.
1995: C Schmidt; F Bladt; S Goedecke; Volker Brinkmann; W Zschiesche; M Sharpe; Ermanno Gherardi; Carmen Birchmeier
Scatter factor/hepatocyte growth factor is essential for liver development.
Nature 1995;373(6516):699-702.
1995: Colin M Fitzsimmons; R Bush; D Hele; C Godliman; Ermanno Gherardi; David E Bowyer
Measurement of the absolute number of functioning low-density lipoprotein receptors in vivo using a monoclonal antibody.
The Biochemical journal 1995;305 ( Pt 3)():897-904.
1995: Adrian S Woolf; M Kolatsi-Joannou; P Hardman; E Andermarcher; C Moorby; Leon Fine; Parmjit S Jat; M D Noble; Ermanno Gherardi
Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros.
The Journal of cell biology 1995;128(1-2):171-84.
1995: C Théry; M J Sharpe; S J Batley; Claudio D Stern; Ermanno Gherardi
Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick development.
Developmental genetics 1995;17(1):90-101.
1994: L E Donate; Ermanno Gherardi; N Srinivasan; R Sowdhamini; Samuel A J R Aparicio; Tom L Blundell
Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP).
Protein science : a publication of the Protein Society 1994;3(12):2378-94.
1993: J Wilkinson; Joan A Higgins; Pieter Groot; Ermanno Gherardi; David E Bowyer
Topography of apolipoprotein B in subcellular fractions from rabbit liver.
Biochemical Society transactions 1993;21(2):126S.
1993: Ermanno Gherardi; M Sharpe; K Lane
Properties and structure-function relationship of HGF-SF.
EXS 1993;65():31-48.
1993: Ermanno Gherardi; M Sharpe; K Lane; A Sirulnik; M Stoker
Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behaviour of epithelial cells.
Symposia of the Society for Experimental Biology 1993;47():163-81.
1992: J Wilkinson; Joan A Higgins; Pieter Groot; Ermanno Gherardi; David E Bowyer
Determination of the intracellular distribution and pool sizes of apolipoprotein B in rabbit liver.
The Biochemical journal 1992;288 ( Pt 2)():413-9.
1992: C D Moorby; Ermanno Gherardi; L Dovey; C Godliman; David E Bowyer
Transforming growth factor-beta 1 and interleukin-1 beta stimulate LDL receptor activity in Hep G2 cells.
Atherosclerosis 1992;97(1):21-8.
1992: Cyrus Chothia; Arthur M Lesk; Ermanno Gherardi; Ian M Tomlinson; G Walter; James D Marks; M B Llewelyn; Greg Winter
Structural repertoire of the human VH segments.
Journal of molecular biology 1992;227(3):799-817.
1992: C D Moorby; Ermanno Gherardi; D Riddell; David E Bowyer
Porcine smooth muscle cell-conditioned medium stimulates LDL receptor activity in Hep G2 cells.
Journal of cell science 1992;103 ( Pt 2)():541-9.
1992: Ermanno Gherardi; K Thomas; T D Le Cras; Colin M Fitzsimmons; C D Moorby; David E Bowyer
Growth requirements and expression of LDL receptor and HMG-CoA reductase in Hep G2 hepatoblastoma cells cultured in a chemically defined medium.
Journal of cell science 1992;103 ( Pt 2)():531-9.
1992: J Wilkinson; Joan A Higgins; Pieter Groot; Ermanno Gherardi; David E Bowyer
Membrane-bound apolipoprotein B is exposed at the cytosolic surface of liver microsomes.
FEBS letters 1992;304(1):24-6.
1992: Tahereh Kamalati; B Thirunavukarasu; A Wallace; Nigel Holder; R Brooks; T Nakamura; M Stoker; Ermanno Gherardi; Lakjaya Buluwela
Down-regulation of scatter factor in MRC 5 fibroblasts by epithelial-derived cells. A model for scatter factor modulation.
Journal of cell science 1992;101 ( Pt 2)():323-32.
1991: Ermanno Gherardi; David E Bowyer; Colin M Fitzsimmons; T Le Cras; A Hutchings; G Butcher
Probing of the expression of the low-density lipoprotein receptor in vivo using an anti-receptor monoclonal antibody.
The Biochemical journal 1991;280 ( Pt 1)():1-7.
1991: T D Le Cras; Ermanno Gherardi; David E Bowyer
A sensitive RNase protection assay for the quantitation of the mRNAs for the LDL receptor and HMG-CoA reductase in human total RNA. Effects of treatments on cells in culture designed to up- and down-regulate expression of the LDL receptor.
Atherosclerosis 1991;90(1):81-90.
1991: Ermanno Gherardi; M Stoker
Hepatocyte growth factor--scatter factor: mitogen, motogen, and met.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(6):227-32.
1991: M Stoker; Ermanno Gherardi
Regulation of cell movement: the motogenic cytokines.
Biochimica et biophysica acta 1991;1072(1):81-102.
1990: Claudio D Stern; Grenham Ireland; Sarah E Herrick; Ermanno Gherardi; J Gray; M Perryman; M Stoker
Epithelial scatter factor and development of the chick embryonic axis.
Development (Cambridge, England) 1990;110(4):1271-84.
1990: J Wilkinson; Joan A Higgins; Pieter Groot; Ermanno Gherardi; David E Bowyer
The distribution of apolipoprotein B in endoplasmic reticulum and Golgi subfractions of rabbit liver.
Biochemical Society transactions 1990;18(6):1181.
1990: Ermanno Gherardi; M Stoker
Hepatocytes and scatter factor.
Nature 1990;346(6281):228.
1989: Ermanno Gherardi; J Gray; M Stoker; M Perryman; R Furlong
Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5844-8.
1989: M Stoker; Ermanno Gherardi
Scatter factor and other regulators of cell mobility.
British medical bulletin 1989;45(2):481-91.
1988: Ermanno Gherardi; N Brugni; David E Bowyer
Purification of low density lipoprotein receptor from liver and its quantification by anti-receptor monoclonal antibodies.
The Biochemical journal 1988;253(2):409-15.
1988: Ermanno Gherardi; A Hutchings; G Galfre; David E Bowyer
Rat monoclonal antibodies to rabbit and human serum low-density lipoprotein.
The Biochemical journal 1988;252(1):237-45.
1987: M Stoker; Ermanno Gherardi; M Perryman; J Gray
Scatter factor is a fibroblast-derived modulator of epithelial cell mobility.
Nature 1987;327(6119):239-42.
1987: M Stoker; Ermanno Gherardi
Factors affecting epithelial interactions.
Ciba Foundation symposium 1987;125():217-39.