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Andrew Ghio

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Caroline P Ozment; Mary Lee Campbell; Andrew J Ghio; Yuliya Lokhnygina; Lisa B Mamo; Jennifer L Turi
Transfusion-related biologic effects and free hemoglobin, heme, and iron.
William E Funk; John K McGee; Andrew F Olshan; Andrew J Ghio
Quantification of arsenic, lead, mercury and cadmium in newborn dried blood spots.
Jeanine D'Armiento; John E Connett; Patrick Geraghty; Andrew J Ghio; Monica P Goldklang; Andrew A Hardigan; Monirul Islam; Michael D Roth; Steven M Scharf; Frank C Sciurba; Jincy Thankachen; Robert Wise; Robert F Foronjy
Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema.

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2013: Caroline P Ozment; Mary Lee Campbell; Andrew J Ghio; Yuliya Lokhnygina; Lisa B Mamo; Jennifer L Turi
Transfusion-related biologic effects and free hemoglobin, heme, and iron.
Transfusion 2013;53(4):732-40.
2013: William E Funk; John K McGee; Andrew F Olshan; Andrew J Ghio
Quantification of arsenic, lead, mercury and cadmium in newborn dried blood spots.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2013;18(2):174-7.
2013: Jeanine D'Armiento; John E Connett; Patrick Geraghty; Andrew J Ghio; Monica P Goldklang; Andrew A Hardigan; Monirul Islam; Michael D Roth; Steven M Scharf; Frank C Sciurba; Jincy Thankachen; Robert Wise; Robert F Foronjy
Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema.
PloS one 2013;8(2):e56352.
2012: Yuh-Chin T Huang; Ana G Rappold; Andrew J Ghio; Donald W Graff; Robert B Devlin
Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans.
Inhalation toxicology 2012;24(12):790-7.
2012: Jerome A Roth; Balakrishnan Ganapathy; Andrew J Ghio
Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin.
Toxicology in vitro : an international journal published in association with BIBRA 2012;26(7):1143-9.
2012: Marisa L Meyer; Erin N Potts-Kant; Bernard M Fischer; W Michael Foster; Andrew J Ghio; Judith A Voynow
NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia.
American journal of physiology. Lung cellular and molecular physiology 2012;303(3):L181-8.
2012: Jonathan H Shannahan; Witold M Winnik; Mette C Schladweiler; Oscar Alzate; Debora Andrews; Stephen H Gavett; Andrew J Ghio; Urmila P Kodavanti
Acute phase response, inflammation and metabolic syndrome biomarkers of Libby asbestos exposure.
Toxicology and applied pharmacology 2012;260(2):105-14.
2012: Andrew J Ghio; Joachim D Pleil; Jon R Sobus; Michael C Madden
Controlled human exposures to diesel exhaust.
Swiss medical weekly 2012;142():w13597.
2011: Jonathan H Shannahan; Andrew J Ghio; Mette C Schladweiler; John K McGee; Judy H Richards; Stephen H Gavett; Urmila P Kodavanti
The role of iron in Libby amphibole-induced acute lung injury and inflammation.
Inhalation toxicology 2011;23(6):313-23.
2011: Andrew J Ghio; Joleen M Soukup; Lisa A Dailey; Judy Richards; Zhongping Deng; Jerrold L Abraham
Gadolinium exposure disrupts iron homeostasis in cultured cells.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(4):567-75.
2011: Marie D Frazier; Andrew J Ghio; Lisa B Mamo; Jennifer L Turi
Hepcidin expression in human airway epithelial cells is regulated by interferon-γ.
Respiratory research 2011;12():100.
2011: G R Scott Budinger; Joanne L McKell; Daniela Urich; Nancy Foiles; Ivy Weiss; Sergio E Chiarella; Angel Gonzalez; Saul Soberanes; Andrew J Ghio; Recep Nigdelioglu; Ece A Mutlu; Kathryn A Radigan; David Green; Hau C Kwaan; Gökhan M Mutlu
Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms.
PloS one 2011;6(4):e18525.
2010: Kelly E Duncan; Andrew J Ghio; Lisa A Dailey; Amy M Bern; Eugene A Gibbs-Flournoy; Danielle J Padilla-Carlin; Victor L Roggli; Robert B Devlin
Effect of size fractionation on the toxicity of amosite and Libby amphibole asbestos.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(2):420-34.
2010: Funmei Yang; Jacqueline G Stonehuerner; Judy H Richards; Ngoc-Bich Nguyen; Kimberly D Callaghan; David Haile; Andrew J Ghio
Deficiency in the divalent metal transporter 1 increases bleomycin-induced lung injury.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2010;23(4):657-67.
2010: Rahul G Sangani; Joleen M Soukup; Andrew J Ghio
Metals in air pollution particles decrease whole-blood coagulation time.
Inhalation toxicology 2010;22(8):621-6.
2010: Rachel McIntosh; Sungryul Lee; Andrew J Ghio; Jinkun Xi; Min Zhu; Xiangjun Shen; Guillaume Chanoit; David Zvara; Zhelong Xu
The critical role of intracellular zinc in adenosine A(2) receptor activation induced cardioprotection against reperfusion injury.
Journal of molecular and cellular cardiology 2010;49(1):41-7.
2010: Andrew J Ghio; Rahul G Sangani; Luisa E Brighton; Johnny L Carson
MRT letter: Auto-fluorescence by human alveolar macrophages after in vitro exposure to air pollution particles.
Microscopy research and technique 2010;73(6):579-82.
2010: Mitchell D Cohen; Maureen Sisco; Colette Prophete; Kotaro Yoshida; Lung Chi Chen; Judith T Zelikoff; Jason Smee; Alvin Holder; Jacqueline Stonehuerner; Debbie C Crans; Andrew J Ghio
Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium.
Inhalation toxicology 2010;22(2):169-78.
2010: Jonathan H Shannahan; Mette C Schladweiler; Judy H Richards; Allen D Ledbetter; Andrew J Ghio; Urmila P Kodavanti
Pulmonary oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular disease.
Journal of toxicology and environmental health. Part A 2010;73(10):641-56.
2010: K Sawyer; S Mundandhara; Andrew J Ghio; Michael C Madden
The effects of ambient particulate matter on human alveolar macrophage oxidative and inflammatory responses.
Journal of toxicology and environmental health. Part A 2010;73(1):41-57.
2009: Bernard M Fischer; Denise A Lopez Domowicz; Shuo Zheng; Jamie L Carter; N Gerry McElvaney; Clifford Taggart; James R Lehmann; Judith A Voynow; Andrew J Ghio
Neutrophil elastase increases airway epithelial nonheme iron levels.
Clinical and translational science 2009;2(5):333-9.
2009: Zhongping Deng; Lisa A Dailey; Joleen Soukup; Jacqueline Stonehuerner; Judy D Richards; Kimberly D Callaghan; Funmei Yang; Andrew J Ghio
Zinc transport by respiratory epithelial cells and interaction with iron homeostasis.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2009;22(5):803-15.
2009: Andrew J Ghio; Lisa A Dailey; Judy H Richards; Myoseon Jang
Acid and organic aerosol coatings on magnetic nanoparticles increase iron concentrations in human airway epithelial cells.
Inhalation toxicology 2009;21(8):659-67.
2009: Daniela Urich; Saul Soberanes; Zach Burgess; Sergio E Chiarella; Andrew J Ghio; Karen M Ridge; David W Kamp; Navdeep S Chandel; Gökhan M Mutlu; G R Scott Budinger
Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(7):2055-64.
2009: Jinju Li; Andrew J Ghio; Seung-Hyun Cho; Constance E Brinckerhoff; Sidney A Simon; Wolfgang Liedtke
Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS.
Environmental health perspectives 2009;117(3):400-9.
2009: Saul Soberanes; Daniela Urich; Christina M Baker; Zach Burgess; Sergio E Chiarella; Eric L Bell; Andrew J Ghio; Andrea De Vizcaya-Ruiz; Jing Liu; Karen M Ridge; David W Kamp; Navdeep S Chandel; Paul T Schumacker; Gökhan M Mutlu; G R Scott Budinger
Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
The Journal of biological chemistry 2009;284(4):2176-86.
2009: Yuh-Chin T Huang; Andrew J Ghio
Controlled human exposures to ambient pollutant particles in susceptible populations.
Environmental health : a global access science source 2009;8():33.
2008: Andrew J Ghio; Elizabeth D Hilborn; Jacqueline G Stonehuerner; Lisa A Dailey; Jacqueline D Carter; Judy H Richards; Kay M Crissman; Robert F Foronjy; Dale L Uyeminami; Kent E Pinkerton
Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect.
American journal of respiratory and critical care medicine 2008;178(11):1130-8.
2008: O Kamdar; Wei Le; J Zhang; Andrew J Ghio; Glenn D Rosen; Daya Upadhyay
Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium.
FEBS letters 2008;582(25-26):3601-6.
2008: Jennifer L Turi; Claude A Piantadosi; Jackie D Stonehuerner; Andrew J Ghio
Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2008;21(5):571-80.
2008: Andrew J Ghio; Jacqueline G Stonehuerner; Lisa A Dailey; Judy H Richards; Michael D Madden; Zhongping Deng; N-B Nguyen; Kimberly D Callaghan; Funmei Yang; Claude A Piantadosi
Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function.
American journal of respiratory cell and molecular biology 2008;38(6):715-23.
2008: Andrew J Ghio
Mechanism of asthmatic exacerbation by ambient air pollution particles.
Expert review of respiratory medicine 2008;2(1):109-18.
2008: Andrew J Ghio; Jacqueline Stonehuerner; Judy Richards; Robert B Devlin
Iron homeostasis in the lung following asbestos exposure.
Antioxidants & redox signaling 2008;10(2):371-7.
2008: Thaw Sint; James F Donohue; Andrew J Ghio
Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease.
Inhalation toxicology 2008;20(1):25-9.
2008: Andrew J Ghio; Jacqueline G Stonehuerner; Judy H Richards; Kay Crissman; Victor L Roggli; Claude A Piantadosi; Martha Sue Carraway
Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study.
Respiratory research 2008;9():10.
2007: Jingmei Zhang; Andrew J Ghio; Mingxing Gao; Ke Wei; Glenn D Rosen; Daya Upadhyay
Ambient particulate matter induces alveolar epithelial cell cycle arrest: role of G1 cyclins.
FEBS letters 2007;581(27):5315-20.
2007: Gökhan M Mutlu; David Green; Amy Bellmeyer; Christina M Baker; Zach Burgess; Nalini Rajamannan; John W Christman; Nancy Foiles; David W Kamp; Andrew J Ghio; Navdeep S Chandel; David A Dean; Jacob I Sznajder; G R Scott Budinger
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.
The Journal of clinical investigation 2007;117(10):2952-61.
2007: J Zhang; Andrew J Ghio; W Chang; O Kamdar; Glenn D Rosen; Daya Upadhyay
Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells.
FEBS letters 2007;581(22):4148-52.
2007: Shuo Zheng; Angela S Byrd; Bernard M Fischer; Amy R Grover; Andrew J Ghio; Judith A Voynow
Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1.
Free radical biology & medicine 2007;42(9):1398-408.
2007: Kimberly J Swanson; Michael C Madden; Andrew J Ghio
Biodiesel exhaust: the need for health effects research.
Environmental health perspectives 2007;115(4):496-9.
2007: Molly S Bolger; DeAndre S Ross; Haixiang Jiang; Michael M Frank; Andrew J Ghio; David A Schwartz; Jo Rae Wright
Complement levels and activity in the normal and LPS-injured lung.
American journal of physiology. Lung cellular and molecular physiology 2007;292(3):L748-59.
2007: James M Samet; Donald W Graff; Jon Berntsen; Andrew J Ghio; Yuh-Chin T Huang; Robert B Devlin
A comparison of studies on the effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single location.
Inhalation toxicology 2007;19 Suppl 1():29-32.
2007: Andrew J Ghio; Jennifer L Turi; Michael C Madden; Lisa A Dailey; Judy D Richards; Jacqueline G Stonehuerner; Daniel L Morgan; Steven Singleton; Laura M Garrick; Michael D Garrick
Lung injury after ozone exposure is iron dependent.
American journal of physiology. Lung cellular and molecular physiology 2007;292(1):L134-43.
2006: Martha Sue Carraway; Hagir Suliman; Michael C Madden; Claude A Piantadosi; Andrew J Ghio
Metabolic capacity regulates iron homeostasis in endothelial cells.
Free radical biology & medicine 2006;41(11):1662-9.
2006: Saul Soberanes; Vijayalakshmi Panduri; Gökhan M Mutlu; Andrew J Ghio; G R Scott Bundinger; David W Kamp
p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis.
American journal of respiratory and critical care medicine 2006;174(11):1229-38.
2006: Donald E Schmechel; Jeffrey Browndyke; Andrew J Ghio
Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders.
Neurotoxicology 2006;27(5):637-57.
2006: Joshua G McCaskill; Kelly D Chason; Xiaoyang Hua; Isabel P Neuringer; Andrew J Ghio; William K Funkhouser; Stephen L Tilley
Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice.
American journal of respiratory cell and molecular biology 2006;35(3):347-56.
2006: Myoseon Jang; Andrew J Ghio; Gang Cao
Exposure of BEAS-2B cells to secondary organic aerosol coated on magnetic nanoparticles.
Chemical research in toxicology 2006;19(8):1044-50.
2006: Jennifer L Turi; Xinchao Wang; Andrew T McKie; Eva Nozik-Grayck; Lisa B Mamo; Kay Crissman; Claude A Piantadosi; Andrew J Ghio
Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2006;291(2):L272-80.
2006: Yuh-Chin T Huang; Andrew J Ghio
Vascular effects of ambient pollutant particles and metals.
Current vascular pharmacology 2006;4(3):199-203.
2006: Gökhan M Mutlu; Colleen Snyder; Amy Bellmeyer; Helena Wang; Keenan Hawkins; Saul Soberanes; Lynn C Welch; Andrew J Ghio; Navdeep S Chandel; David W Kamp; Jacob I Sznajder; G R Scott Budinger
Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation.
American journal of respiratory cell and molecular biology 2006;34(6):670-6.
2006: Xinchao Wang; Yiming Wu; Jacqueline G Stonehuerner; Lisa A Dailey; Judy D Richards; Ilona Jaspers; Claude A Piantadosi; Andrew J Ghio
Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos.
American journal of respiratory cell and molecular biology 2006;34(3):286-92.
2006: Victor L Roggli; Claude A Piantadosi; Neil R MacIntyre; Stephen L Young; Peter S Kussin; Mark P Steele; Martha Sue Carraway; Karen E Welty-Wolf; Joseph A Govert; Timothy J McMahon; Scott M Palmer; Thomas A Sporn; Andrew J Ghio
Physician subsidies for tobacco advertising.
American journal of respiratory and critical care medicine 2006;173(2):246.
2006: Andrew J Ghio; William K Funkhouser; Christopher B Pugh; Scot Winters; Jacqueline G Stonehuerner; Annabelle M Mahar; Victor L Roggli
Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers.
Toxicologic pathology 2006;34(6):723-9.
2006: Andrew J Ghio; Jennifer L Turi; Funmei Yang; Laura M Garrick; Michael D Garrick
Iron homeostasis in the lung.
Biological research 2006;39(1):67-77.
2006: Karen E Welty-Wolf; Martha Sue Carraway; Thomas L Ortel; Andrew J Ghio; Steven Idell; Jack Egan; Xiaoyun Zhu; Jin-an Jiao; Hing C Wong; Claude A Piantadosi
Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure.
American journal of physiology. Lung cellular and molecular physiology 2006;290(1):L21-31.
2005: Andrew J Ghio; Mitchell D Cohen
Disruption of iron homeostasis as a mechanism of biologic effect by ambient air pollution particles.
Inhalation toxicology 2005;17(13):709-16.
2005: Christopher Pugh; Vasan Hathwar; Judy H Richards; Jacqueline Stonehuerner; Andrew J Ghio
Disruption of iron homeostasis in the lungs of transplant patients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005;24(11):1821-7.
2005: Andrew J Ghio; Claude A Piantadosi; Xinchao Wang; Lisa A Dailey; Jacqueline Stonehuerner; Michael C Madden; Funmei Yang; Kevin G Dolan; Michael D Garrick; Laura M Garrick
Divalent metal transporter-1 decreases metal-related injury in the lung.
American journal of physiology. Lung cellular and molecular physiology 2005;289(3):L460-7.
2005: Robert B Devlin; Mark L Frampton; Andrew J Ghio
In vitro studies: what is their role in toxicology?
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2005;57 Suppl 1():183-8.
2005: Xinchao Wang; Michael D Garrick; Funmei Yang; Lisa A Dailey; Claude A Piantadosi; Andrew J Ghio
TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2005;289(1):L24-33.
2005: Funmei Yang; David Haile; Xinchao Wang; Lisa A Dailey; Jacqueline G Stonehuerner; Andrew J Ghio
Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung.
American journal of physiology. Lung cellular and molecular physiology 2005;289(1):L14-23.
2005: Andrew J Ghio; Earl S Ford; Thomas P Kennedy; John R Hoidal
The association between serum ferritin and uric acid in humans.
Free radical research 2005;39(3):337-42.
2004: Sukhdev S Brar; Claude Grigg; Kimberly S Wilson; Walter D Holder; Didier Dreau; Catherine Austin; Mareva Foster; Andrew J Ghio; A Richard Whorton; Grayson W Stowell; Linda B Whittall; Robert R Whittle; David P White; Thomas P Kennedy
Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease.
Molecular cancer therapeutics 2004;3(9):1049-60.
2004: Jennifer L Turi; Funmei Yang; Michael D Garrick; Claude A Piantadosi; Andrew J Ghio
The iron cycle and oxidative stress in the lung.
Free radical biology & medicine 2004;36(7):850-7.
2004: Andrew J Ghio
Biological effects of Utah Valley ambient air particles in humans: a review.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2004;17(2):157-64.
2004: Andrew J Ghio; Yuh-Chin T Huang
Exposure to concentrated ambient particles (CAPs): a review.
Inhalation toxicology 2004;16(1):53-9.
2003: Andrew J Ghio; Eva Nozik-Grayck; Jennifer L Turi; Ilona Jaspers; Danielle Carrick; Ryszard Kole; Claude A Piantadosi
Superoxide-dependent iron uptake: a new role for anion exchange protein 2.
American journal of respiratory cell and molecular biology 2003;29(6):653-60.
2003: Andrew J Ghio; Victor L Roggli; Judy H Richards; Kay Crissman; Jacqueline Stonehuerner; Claude A Piantadosi
Oxalate deposition on asbestos bodies.
Human pathology 2003;34(8):737-42.
2003: Daya Upadhyay; Vijayalakshmi Panduri; Andrew J Ghio; David W Kamp
Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria.
American journal of respiratory cell and molecular biology 2003;29(2):180-7.
2003: Weidong Wu; Xinchao Wang; Wenli Zhang; William Reed; James M Samet; Young E Whang; Andrew J Ghio
Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells.
The Journal of biological chemistry 2003;278(30):28258-63.
2003: Andrew J Ghio; Xinchao Wang; Robert Silbajoris; Michael D Garrick; Claude A Piantadosi; Funmei Yang
DMT1 expression is increased in the lungs of hypotransferrinemic mice.
American journal of physiology. Lung cellular and molecular physiology 2003;284(6):L938-44.
2003: Martha Sue Carraway; Karen E Welty-Wolf; Debra L Miller; Thomas L Ortel; Steven Idell; Andrew J Ghio; Lars C Petersen; Claude A Piantadosi
Blockade of tissue factor: treatment for organ injury in established sepsis.
American journal of respiratory and critical care medicine 2003;167(9):1200-9.
2003: Yuh-Chin T Huang; Andrew J Ghio; Jacqueline Stonehuerner; John McGee; Jacqueline D Carter; Steven C Grambow; Robert B Devlin
The role of soluble components in ambient fine particles-induced changes in human lungs and blood.
Inhalation toxicology 2003;15(4):327-42.
2003: Michael D Garrick; Kevin G Dolan; Craig Horbinski; Andrew J Ghio; Dennis Higgins; Michael Porubcin; Elizabeth G Moore; Lucille N Hainsworth; Jay N Umbreit; Marcel E Conrad; Lee Feng; Agnieszka Lis; Jerome A Roth; Steven Singleton; Laura M Garrick
DMT1: a mammalian transporter for multiple metals.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2003;16(1):41-54.
2003: Andrew J Ghio; Jacqueline D Carter; Judy H Richards; Lori D Richer; Colin K Grissom; Mark R Elstad
Iron and iron-related proteins in the lower respiratory tract of patients with acute respiratory distress syndrome.
Critical care medicine 2003;31(2):395-400.
2002: Alejandro Molinelli; Michael C Madden; John K McGee; Jacqueline G Stonehuerner; Andrew J Ghio
Effect of metal removal on the toxicity of airborne particulate matter from the Utah Valley.
Inhalation toxicology 2002;14(10):1069-86.
2002: Jennifer L Turi; Ilona Jaspers; Lisa A Dailey; Michael C Madden; Luisa E Brighton; Jacqueline D Carter; Eva Nozik-Grayck; Claude A Piantadosi; Andrew J Ghio
Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2002;283(4):L791-8.
2002: Andrew J Ghio; Thomas P Kennedy; Jacqueline Stonehuerner; Jacqueline D Carter; Kelly A Skinner; Dale A Parks; John R Hoidal
Iron regulates xanthine oxidase activity in the lung.
American journal of physiology. Lung cellular and molecular physiology 2002;283(3):L563-72.
2002: Andrew J Ghio; Hagir Suliman; Jacqueline D Carter; Amir M Abushamaa; Rodney J Folz
Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash.
American journal of physiology. Lung cellular and molecular physiology 2002;283(1):L211-8.
2002: Debra L Miller; Karen E Welty-Wolf; Martha Sue Carraway; Mirella Ezban; Andrew J Ghio; Hagir Suliman; Claude A Piantadosi
Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide.
American journal of respiratory cell and molecular biology 2002;26(6):650-8.
2002: Xinchao Wang; Andrew J Ghio; Funmei Yang; Kevin G Dolan; Michael D Garrick; Claude A Piantadosi
Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L987-95.
2002: Neil E Alexis; Judy H Richards; Jacqueline D Carter; Andrew J Ghio
Iron-binding and storage proteins in sputum.
Inhalation toxicology 2002;14(4):387-400.
2002: Martha Sue Carraway; Andrew J Ghio; Hagir Suliman; Jacqueline D Carter; A Richard Whorton; Claude A Piantadosi
Carbon monoxide promotes hypoxic pulmonary vascular remodeling.
American journal of physiology. Lung cellular and molecular physiology 2002;282(4):L693-702.
2002: Andrew J Ghio; Robert Silbajoris; Johnny L Carson; James M Samet
Biologic effects of oil fly ash.
Environmental health perspectives 2002;110 Suppl 1():89-94.
2002: Hagir Suliman; Martha Sue Carraway; Leonard W Velsor; Brian Day; Andrew J Ghio; Claude A Piantadosi
Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure.
Free radical biology & medicine 2002;32(3):246-56.
2002: Yuh-Chin T Huang; Weidong Wu; Andrew J Ghio; Jacqueline D Carter; Robert Silbajoris; Robert B Devlin; James M Samet
Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash.
Experimental lung research 2002;28(1):19-38.
2001: John Lay; Kirby L Zeman; Andrew J Ghio; William D Bennett
Effects of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects.
Inhalation toxicology 2001;13(12):1065-78.
2001: Karen E Welty-Wolf; Martha Sue Carraway; Debra L Miller; Thomas L Ortel; Mirella Ezban; Andrew J Ghio; Steven Idell; Claude A Piantadosi
Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons.
American journal of respiratory and critical care medicine 2001;164(10 Pt 1):1988-96.
2001: Andrew J Ghio; J G Gilbey; Victor L Roggli; Judy H Richards; John K McGee; Johnny L Carson; Robert B Devlin; Wayne E Cascio
Diffuse alveolar damage after exposure to an oil fly ash.
American journal of respiratory and critical care medicine 2001;164(8 Pt 1):1514-8.
2001: Andrew J Ghio; Robert B Devlin
Inflammatory lung injury after bronchial instillation of air pollution particles.
American journal of respiratory and critical care medicine 2001;164(4):704-8.
2001: S D Harder; Joleen M Soukup; Andrew J Ghio; Robert B Devlin; Susanne Becker
Inhalation of PM2.5 does not modulate host defense or immune parameters in blood or lung of normal human subjects.
Environmental health perspectives 2001;109 Suppl 4():599-604.
2001: Weidong Wu; James M Samet; Andrew J Ghio; Robert B Devlin
Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.
American journal of physiology. Lung cellular and molecular physiology 2001;281(2):L483-9.
2001: AK Prahalad; J Inmon; Lisa A Dailey; Michael C Madden; Andrew J Ghio; Jane E Gallagher
Air pollution particles mediated oxidative DNA base damage in a cell free system and in human airway epithelial cells in relation to particulate metal content and bioreactivity.
Chemical research in toxicology 2001;14(7):879-87.
2001: Janice A Dye; James R Lehmann; John K McGee; Darrell W Winsett; Allen D Ledbetter; Jeffrey I Everitt; Andrew J Ghio; Daniel L Costa
Acute pulmonary toxicity of particulate matter filter extracts in rats: coherence with epidemiologic studies in Utah Valley residents.
Environmental health perspectives 2001;109 Suppl 3():395-403.
2001: Sukhdev S Brar; Thomas P Kennedy; A Richard Whorton; Anne B Sturrock; Thomas P Huecksteadt; Andrew J Ghio; John R Hoidal
Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells.
American journal of physiology. Cell physiology 2001;280(3):C659-76.
2001: Y T Huang; Andrew J Ghio; Eva Nozik-Grayck; Claude A Piantadosi
Vascular release of nonheme iron in perfused rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(3):L474-81.
2000: Wendy T Watford; Andrew J Ghio; Jo Rae Wright
Complement-mediated host defense in the lung.
American journal of physiology. Lung cellular and molecular physiology 2000;279(5):L790-8.
2000: Michael C Madden; Judy H Richards; Lisa A Dailey; Gary E Hatch; Andrew J Ghio
Effect of ozone on diesel exhaust particle toxicity in rat lung.
Toxicology and applied pharmacology 2000;168(2):140-8.
2000: AK Prahalad; J Inmon; Andrew J Ghio; Jane E Gallagher
Enhancement of 2'-deoxyguanosine hydroxylation and DNA damage by coal and oil fly ash in relation to particulate metal content and availability.
Chemical research in toxicology 2000;13(10):1011-9.
2000: Neil E Alexis; Joleen M Soukup; Andrew J Ghio; S Becker
Sputum phagocytes from healthy individuals are functional and activated: a flow cytometric comparison with cells in bronchoalveolar lavage and peripheral blood.
Clinical immunology (Orlando, Fla.) 2000;97(1):21-32.
2000: Andrew J Ghio; Judy H Richards; Kay Crissman; Jacqueline D Carter
Iron disequilibrium in the rat lung after instilled blood.
Chest 2000;118(3):814-23.
2000: Andrew J Ghio; C Kim; Robert B Devlin
Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers.
American journal of respiratory and critical care medicine 2000;162(3 Pt 1):981-8.
2000: Andrew J Ghio; Judy H Richards; Jacqueline D Carter; Michael C Madden
Accumulation of iron in the rat lung after tracheal instillation of diesel particles.
Toxicologic pathology 2000;28(4):619-27.
2000: Andrew J Ghio; Victor L Roggli; T P Kennedy; Claude A Piantadosi
Calcium oxalate and iron accumulation in sarcoidosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 2000;17(2):140-50.
2000: Robert Silbajoris; Andrew J Ghio; James M Samet; Richard H Jaskot; Kevin L Dreher; L E Brighton
In vivo and in vitro correlation of pulmonary MAP kinase activation following metallic exposure.
Inhalation toxicology 2000;12(6):453-68.
2000: Joleen M Soukup; Andrew J Ghio; Susanne Becker
Soluble components of Utah Valley particulate pollution alter alveolar macrophage function in vivo and in vitro.
Inhalation toxicology 2000;12(5):401-14.
2000: Karen E Welty-Wolf; Martha Sue Carraway; Andrew J Ghio; SP Kantrow; Yuh-Chin T Huang; Claude A Piantadosi
Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy.
Shock (Augusta, Ga.) 2000;13(5):404-9.
2000: Andrew J Ghio; Jacqueline D Carter; Judy H Richards; Kay Crissman; H H Bobb; Funmei Yang
Diminished injury in hypotransferrinemic mice after exposure to a metal-rich particle.
American journal of physiology. Lung cellular and molecular physiology 2000;278(5):L1051-61.
2000: Martha Sue Carraway; Andrew J Ghio; J D Carter; Claude A Piantadosi
Detection of granulocyte-macrophage colony-stimulating factor in patients with pulmonary alveolar proteinosis.
American journal of respiratory and critical care medicine 2000;161(4 Pt 1):1294-9.
2000: Martha Sue Carraway; Andrew J Ghio; Jacqueline D Carter; Claude A Piantadosi
Expression of heme oxygenase-1 in the lung in chronic hypoxia.
American journal of physiology. Lung cellular and molecular physiology 2000;278(4):L806-12.
2000: James M Samet; Andrew J Ghio; Daniel L Costa; M C Madden
Increased expression of cyclooxygenase 2 mediates oil fly ash-induced lung injury.
Experimental lung research 2000;26(1):57-69.
1999: S Sachs; Andrew J Ghio; Stephen L Young
Tyloxapol confers durable protection against hyperoxic lung injury in the rat.
Experimental lung research 1999;25(6):543-59.
1999: AK Prahalad; J M Soukup; J Inmon; R Willis; Andrew J Ghio; Susanne Becker; Jane E Gallagher
Ambient air particles: effects on cellular oxidant radical generation in relation to particulate elemental chemistry.
Toxicology and applied pharmacology 1999;158(2):81-91.
1999: Michael C Madden; M J Thomas; Andrew J Ghio
Acetaldehyde (CH3CHO) production in rodent lung after exposure to metal-rich particles.
Free radical biology & medicine 1999;26(11-12):1569-77.
1999: Andrew J Ghio; Jacqueline D Carter; Lisa A Dailey; Robert B Devlin; James M Samet
Respiratory epithelial cells demonstrate lactoferrin receptors that increase after metal exposure.
The American journal of physiology 1999;276(6 Pt 1):L933-40.
1999: Andrew J Ghio; J Stoneheurner; John K McGee; J S Kinsey
Sulfate content correlates with iron concentrations in ambient air pollution particles.
Inhalation toxicology 1999;11(4):293-307.
1999: John Lay; William D Bennett; Andrew J Ghio; Philip A Bromberg; Daniel L Costa; C S Kim; Hillel S Koren; Robert B Devlin
Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles.
American journal of respiratory cell and molecular biology 1999;20(4):631-42.
1999: Andrew J Ghio; Jacqueline Stonehuerner; Lisa A Dailey; Jacqueline D Carter
Metals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stress.
Inhalation toxicology 1999;11(1):37-49.
1998: T Kennedy; Andrew J Ghio; William Reed; J Samet; J Zagorski; JL Quay; J Carter; Lisa A Dailey; John R Hoidal; Robert B Devlin
Copper-dependent inflammation and nuclear factor-kappaB activation by particulate air pollution.
American journal of respiratory cell and molecular biology 1998;19(3):366-78.
1998: Martha Sue Carraway; Andrew J Ghio; J L Taylor; Claude A Piantadosi
Induction of ferritin and heme oxygenase-1 by endotoxin in the lung.
The American journal of physiology 1998;275(3 Pt 1):L583-92.
1998: James M Samet; Lee M Graves; JL Quay; Lisa A Dailey; Robert B Devlin; Andrew J Ghio; Weidong Wu; Philip A Bromberg; William Reed
Activation of MAPKs in human bronchial epithelial cells exposed to metals.
The American journal of physiology 1998;275(3 Pt 1):L551-8.
1998: Andrew J Ghio; Jacqueline D Carter; James M Samet; William Reed; JL Quay; Lisa A Dailey; Judy H Richards; Robert B Devlin
Metal-dependent expression of ferritin and lactoferrin by respiratory epithelial cells.
The American journal of physiology 1998;274(5 Pt 1):L728-36.
1998: Andrew J Ghio; Judy H Richards; K L Dittrich; James M Samet
Metal storage and transport proteins increase after exposure of the rat lung to an air pollution particle.
Toxicologic pathology 1998;26(3):388-94.
1998: Andrew J Ghio; Thomas P Kennedy; Kay Crissman; Judy H Richards; Gary E Hatch
Depletion of iron and ascorbate in rodents diminishes lung injury after silica.
Experimental lung research 1998;24(2):219-32.
1998: Andrew J Ghio; Jacqueline D Carter; Judy H Richards; Luisa E Brighton; John Lay; Robert B Devlin
Disruption of normal iron homeostasis after bronchial instillation of an iron-containing particle.
The American journal of physiology 1998;274(3 Pt 1):L396-403.
1998: Andrew J Ghio; D E Taylor; J G Stonehuerner; Claude A Piantadosi; Alvin L Crumbliss
The release of iron from different asbestos structures by hydrogen peroxide with concomitant O2 generation.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 1998;11(1):41-7.
1998: Andrew J Ghio; M B Kadiiska; Q H Xiang; R P Mason
In vivo evidence of free radical formation after asbestos instillation: an ESR spin trapping investigation.
Free radical biology & medicine 1998;24(1):11-7.
1997: Andrew J Ghio; Jacqueline D Carter; James M Samet; JL Quay; I A Wortman; Judy H Richards; Thomas P Kennedy; Robert B Devlin
Ferritin expression after in vitro exposures of human alveolar macrophages to silica is iron-dependent.
American journal of respiratory cell and molecular biology 1997;17(5):533-40.
1997: Maria B Kadiiska; Ronald P Mason; Kevin L Dreher; Daniel L Costa; Andrew J Ghio
In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle.
Chemical research in toxicology 1997;10(10):1104-8.
1997: Jacqueline D Carter; Andrew J Ghio; James M Samet; Robert B Devlin
Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent.
Toxicology and applied pharmacology 1997;146(2):180-8.
1997: Andrew J Ghio; Claude A Piantadosi; A L Crumbliss
Hypothesis: iron chelation plays a vital role in neutrophilic inflammation.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 1997;10(2):135-42.
1997: Urmila P Kodavanti; Richard H Jaskot; WY Su; Daniel L Costa; Andrew J Ghio; Kevin L Dreher
Genetic variability in combustion particle-induced chronic lung injury.
The American journal of physiology 1997;272(3 Pt 1):L521-32.
1997: James M Samet; Jacqueline Stonehuerner; William Reed; Robert B Devlin; Lisa A Dailey; Thomas P Kennedy; Philip A Bromberg; Andrew J Ghio
Disruption of protein tyrosine phosphate homeostasis in bronchial epithelial cells exposed to oil fly ash.
The American journal of physiology 1997;272(3 Pt 1):L426-32.
1997: Kevin L Dreher; Richard H Jaskot; James R Lehmann; Judy H Richards; John K McGee; Andrew J Ghio; Daniel L Costa
Soluble transition metals mediate residual oil fly ash induced acute lung injury.
Journal of toxicology and environmental health 1997;50(3):285-305.
1997: Andrew J Ghio; A LeFurgey; Victor L Roggli
In vivo accumulation of iron on crocidolite is associated with decrements in oxidant generation by the fiber.
Journal of toxicology and environmental health 1997;50(2):125-42.
1997: Andrew J Ghio; R J Pritchard; K L Dittrich; J M Samet
Non-heme (Fe3+) in the lung increases with age in both humans and rats.
The Journal of laboratory and clinical medicine 1997;129(1):53-61.
1996: James M Samet; William Reed; Andrew J Ghio; Robert B Devlin; Jacqueline D Carter; Lisa A Dailey; Philip A Bromberg; Michael C Madden
Induction of prostaglandin H synthase 2 in human airway epithelial cells exposed to residual oil fly ash.
Toxicology and applied pharmacology 1996;141(1):159-68.
1996: Andrew J Ghio; R J Pritchard; James R Lehmann; Darrell W Winsett; Gary E Hatch
Lung inflammation after exposure to nonfibrous silicates increases with chelatable [Fe3+].
Journal of toxicology and environmental health 1996;49(1):11-28.
1996: Andrew J Ghio; B C Marshall; J L Diaz; T Hasegawa; Wayne M Samuelson; D Povia; Thomas P Kennedy; C A Piantodosi
Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.
American journal of respiratory and critical care medicine 1996;154(3 Pt 1):783-8.
1996: Andrew J Ghio; Gary E Hatch
Tolerance to phosgene is associated with a neutrophilic influx into the rat lung.
American journal of respiratory and critical care medicine 1996;153(3):1064-71.
1996: J B Pracyk; SG Simonson; Stephen L Young; Andrew J Ghio; V L Roggli; Claude A Piantadosi
Composition of lung lavage in pulmonary alveolar microlithiasis.
Respiration; international review of thoracic diseases 1996;63(4):254-60.
1995: Tim D Oury; L Tatro; Andrew J Ghio; Claude A Piantadosi
Nitration of tyrosine by hydrogen peroxide and nitrite.
Free radical research 1995;23(6):537-47.
1995: J W McDonald; Andrew J Ghio; C E Sheehan; P F Bernhardt; Victor L Roggli
Rare earth (cerium oxide) pneumoconiosis: analytical scanning electron microscopy and literature review.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1995;8(8):859-65.
1995: Ralph M Schapira; Andrew J Ghio; Richard M Effros; J Morrisey; Urias Almagro; Christopher A Dawson; A D Hacker
Hydroxyl radical production and lung injury in the rat following silica or titanium dioxide instillation in vivo.
American journal of respiratory cell and molecular biology 1995;12(2):220-6.
1995: D E Taylor; Andrew J Ghio; Claude A Piantadosi
Reactive oxygen species produced by liver mitochondria of rats in sepsis.
Archives of biochemistry and biophysics 1995;316(1):70-6.
1994: Andrew J Ghio; Jacqueline Stonehuerner; M P Steele; Alvin L Crumbliss
Phagocyte-generated superoxide reduces Fe3+ to displace it from the surface of asbestos.
Archives of biochemistry and biophysics 1994;315(2):219-25.
1994: Andrew J Ghio; Richard H Jaskot; Gary E Hatch
Lung injury after silica instillation is associated with an accumulation of iron in rats.
The American journal of physiology 1994;267(6 Pt 1):L686-92.
1994: Andrew J Ghio; Thomas P Kennedy; G Rao; C L Cooke; M J Miller; John R Hoidal
Complexation of iron cation by sodium urate crystals and gouty inflammation.
Archives of biochemistry and biophysics 1994;313(2):215-21.
1994: Andrew J Ghio; D R Quigley
Complexation of iron by humic-like substances in lung tissue: role in coal workers' pneumoconiosis.
The American journal of physiology 1994;267(2 Pt 1):L173-9.
1994: Andrew J Ghio; Thomas P Kennedy; Jacqueline Stonehuerner; Alvin L Crumbliss; John R Hoidal
DNA strand breaks following in vitro exposure to asbestos increase with surface-complexed [Fe3+].
Archives of biochemistry and biophysics 1994;311(1):13-8.
1994: Ralph M Schapira; Andrew J Ghio; Richard M Effros; J Morrisey; Christopher A Dawson; A D Hacker
Hydroxyl radicals are formed in the rat lung after asbestos instillation in vivo.
American journal of respiratory cell and molecular biology 1994;10(5):573-9.
1994: Andrew J Ghio; Jacqueline Stonehuerner; D R Quigley
Humic-like substances in cigarette smoke condensate and lung tissue of smokers.
The American journal of physiology 1994;266(4 Pt 1):L382-8.
1993: Andrew J Ghio; Gary E Hatch
Lavage phospholipid concentration after silica instillation in the rat is associated with complexed [Fe3+] on the dust surface.
American journal of respiratory cell and molecular biology 1993;8(4):403-7.
1992: Andrew J Ghio; Thomas P Kennedy; A R Whorton; Alvin L Crumbliss; Gary E Hatch; John R Hoidal
Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates.
The American journal of physiology 1992;263(5 Pt 1):L511-8.
1992: Andrew J Ghio; J Zhang; Claude A Piantadosi
Generation of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+].
Archives of biochemistry and biophysics 1992;298(2):646-50.
1991: Andrew J Ghio; Thomas P Kennedy; Gary E Hatch; J S Tepper
Reduction of neutrophil influx diminishes lung injury and mortality following phosgene inhalation.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(2):657-65.
1990: Y. Leon Guo; Thomas P Kennedy; JR Michael; Alfred M Sciuto; Andrew J Ghio; N FRANKLIN ADKINSON; G H Gurtner
Mechanism of phosgene-induced lung toxicity: role of arachidonate mediators.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(5):1615-22.
1990: Andrew J Ghio; Thomas P Kennedy; Ralph M Schapira; Alvin L Crumbliss; John R Hoidal
Hypothesis: is lung disease after silicate inhalation caused by oxidant generation?
Lancet 1990;336(8721):967-9.