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Sandro Ghisla

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Adrian Alder; Peter Beyer; Peter Bigler; Harro Bouwmeester; Mark Bruno; Sandro Ghisla; Muhammad Jamil; Mattia Marzorati; Martina Vermathen; Salim Al-Babili
The path from β-carotene to carlactone, a strigolactone-like plant hormone.
Patrick Schaub; Qiuju Yu; Salim Al-Babili; Jean Cavarelli; Sandra Gemmecker; Sandro Ghisla; Justine Mailliot; Alastair G McEwen; Pierre Poussin-Courmontagne; Peter Beyer
On the structure and function of the phytoene desaturase CRTI from Pantoea ananatis, a membrane-peripheral and FAD-dependent oxidase/isomerase.
Sandro Ghisla; Loredano Pollegioni; Gianluca Molla
Revisitation of the βCl-elimination reaction of D-amino acid oxidase: new interpretation of the reaction that sparked flavoprotein dehydrogenation mechanisms.

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2012: Adrian Alder; Peter Beyer; Peter Bigler; Harro Bouwmeester; Mark Bruno; Sandro Ghisla; Muhammad Jamil; Mattia Marzorati; Martina Vermathen; Salim Al-Babili
The path from β-carotene to carlactone, a strigolactone-like plant hormone.
Science (New York, N.Y.) 2012;335(6074):1348-51.
2012: Patrick Schaub; Qiuju Yu; Salim Al-Babili; Jean Cavarelli; Sandra Gemmecker; Sandro Ghisla; Justine Mailliot; Alastair G McEwen; Pierre Poussin-Courmontagne; Peter Beyer
On the structure and function of the phytoene desaturase CRTI from Pantoea ananatis, a membrane-peripheral and FAD-dependent oxidase/isomerase.
PloS one 2012;7(6):e39550.
2011: Sandro Ghisla; Loredano Pollegioni; Gianluca Molla
Revisitation of the βCl-elimination reaction of D-amino acid oxidase: new interpretation of the reaction that sparked flavoprotein dehydrogenation mechanisms.
The Journal of biological chemistry 2011;286(47):40987-98.
2011: Qiuju Yu; Sandro Ghisla; Joseph Hirschberg; Varda Mann; Peter Beyer
Plant carotene cis-trans isomerase CRTISO: a new member of the FAD(RED)-dependent flavoproteins catalyzing non-redox reactions.
The Journal of biological chemistry 2011;286(10):8666-76.
2011: Elena Rosini; Gianluca Molla; Sandro Ghisla; Loredano Pollegioni
On the reaction of D-amino acid oxidase with dioxygen: O2 diffusion pathways and enhancement of reactivity.
The FEBS journal 2011;278(3):482-92.
2010: Jan Saam; Elena Rosini; Gianluca Molla; Klaus Schulten; Loredano Pollegioni; Sandro Ghisla
O2 reactivity of flavoproteins: dynamic access of dioxygen to the active site and role of a H+ relay system in D-amino acid oxidase.
The Journal of biological chemistry 2010;285(32):24439-46.
2010: Qiuju Yu; Patrick Schaub; Sandro Ghisla; Salim Al-Babili; Anja Krieger-Liszkay; Peter Beyer
The lycopene cyclase CrtY from Pantoea ananatis (formerly Erwinia uredovora) catalyzes an FADred-dependent non-redox reaction.
The Journal of biological chemistry 2010;285(16):12109-20.
2009: Alice Vrielink; Sandro Ghisla
Cholesterol oxidase: biochemistry and structural features.
The FEBS journal 2009;276(23):6826-43.
2009: Elena Rosini; Loredano Pollegioni; Sandro Ghisla; Roberto Orru; Gianluca Molla
Optimization of D-amino acid oxidase for low substrate concentrations--towards a cancer enzyme therapy.
The FEBS journal 2009;276(17):4921-32.
2009: Mattia Pedotti; Sandro Ghisla; Laura Motteran; Gianluca Molla; Loredano Pollegioni
Catalytic and redox properties of glycine oxidase from Bacillus subtilis.
Biochimie 2009;91(5):604-12.
2008: Luciano Piubelli; Mattia Pedotti; Gianluca Molla; Susanne Feindler-Boeckh; Sandro Ghisla; Mirella S Pilone; Loredano Pollegioni
On the oxygen reactivity of flavoprotein oxidases: an oxygen access tunnel and gate in brevibacterium sterolicum cholesterol oxidase.
The Journal of biological chemistry 2008;283(36):24738-47.
2008: Sudharsana Rao Ande; Heike Fussi; Heide Knauer; Michael Murkovic; Sandro Ghisla; Kai-Uwe Fröhlich; Peter Macheroux
Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma.
Yeast (Chichester, England) 2008;25(5):349-57.
2008: Stefan Schildknecht; Andreas Daiber; Sandro Ghisla; Richard A Cohen; Markus Bachschmid
Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):215-24.
2007: Robert Gradinaru; Richard Schowen; Sandro Ghisla
Solvent isotope effects in reactions of human medium-chain acyl-CoA dehydrogenase active site mutants.
Biochemistry 2007;46(9):2497-509.
2007: Phaneeswara-Rao Kommoju; Peter Macheroux; Sandro Ghisla
Molecular cloning, expression and purification of L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma.
Protein expression and purification 2007;52(1):89-95.
2006: Louis Lim; Gianluca Molla; Nicole Guinn; Sandro Ghisla; Loredano Pollegioni; Alice Vrielink
Structural and kinetic analyses of the H121A mutant of cholesterol oxidase.
The Biochemical journal 2006;400(1):13-22.
2006: Sudharsana Rao Ande; Phaneeswara-Rao Kommoju; Sigrid Draxl; Michael Murkovic; Peter Macheroux; Sandro Ghisla; Elisa Ferrando-May
Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom.
Apoptosis : an international journal on programmed cell death 2006;11(8):1439-51.
2005: Kai Tittmann; Georg Wille; Ralph Golbik; Annett Weidner; Sandro Ghisla; Gerhard Hübner
Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum. Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FAD semiquinone/hydroxyethyl-ThDP radical pair.
Biochemistry 2005;44(40):13291-303.
2005: Peter Macheroux; Sandro Ghisla; Christoph Sanner; Heinz Rüterjans; Franz Müller
Reduced flavin: NMR investigation of N5-H exchange mechanism, estimation of ionisation constants and assessment of properties as biological catalyst.
BMC biochemistry 2005;6():26.
2004: Angelo Boselli; Luciano Piubelli; Gianluca Molla; Silvia Sacchi; Mirella S Pilone; Sandro Ghisla; Loredano Pollegioni
On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335.
Biochimica et biophysica acta 2004;1702(1):19-32.
2004: Ibrahim Nasser; Al-Walid A Mohsen; Ilian Jelesarov; Jerry Vockley; Peter Macheroux; Sandro Ghisla
Thermal unfolding of medium-chain acyl-CoA dehydrogenase and iso(3)valeryl-CoA dehydrogenase: study of the effect of genetic defects on enzyme stability.
Biochimica et biophysica acta 2004;1690(1):22-32.
2004: Sandro Ghisla; Colin Thorpe
Acyl-CoA dehydrogenases. A mechanistic overview.
European journal of biochemistry / FEBS 2004;271(3):494-508.
2004: Sandro Ghisla
Beta-oxidation of fatty acids. A century of discovery.
European journal of biochemistry / FEBS 2004;271(3):459-61.
2002: Loredano Pollegioni; Kay Diederichs; Gianluca Molla; Stephan Umhau; Wolfram Welte; Sandro Ghisla; Mirella S Pilone
Yeast D-amino acid oxidase: structural basis of its catalytic properties.
Journal of molecular biology 2002;324(3):535-46.
2002: Tien V Nguyen; Brage S Andresen; Thomas J Corydon; Sandro Ghisla; Nasser Abd-El Razik; Al-Walid A Mohsen; Stephen D Cederbaum; Diane S Roe; Charles R Roe; Nicolas J Lench; Jerry Vockley
Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans.
Molecular genetics and metabolism 2002;77(1-2):68-79.
2001: Loredano Pollegioni; CM Harris; Gianluca Molla; Mirella S Pilone; Sandro Ghisla
Identification and role of ionizing functional groups at the active center of Rhodotorula gracilis D-amino acid oxidase.
FEBS letters 2001;507(3):323-6.
2001: CM Harris; Loredano Pollegioni; Sandro Ghisla
pH and kinetic isotope effects in d-amino acid oxidase catalysis.
European journal of biochemistry / FEBS 2001;268(21):5504-20.
2001: R Coulombe; K Q Yue; Sandro Ghisla; Alice Vrielink
Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair.
The Journal of biological chemistry 2001;276(32):30435-41.
2001: A Geyer; T B Fitzpatrick; Peter D Pawelek; Karina Kitzing; Alice Vrielink; Sandro Ghisla; Peter Macheroux
Structure and characterization of the glycan moiety of L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma.
European journal of biochemistry / FEBS 2001;268(14):4044-53.
2001: Laura Motteran; Mirella S Pilone; Gianluca Molla; Sandro Ghisla; Loredano Pollegioni
Cholesterol oxidase from Brevibacterium sterolicum. The relationship between covalent flavinylation and redox properties.
The Journal of biological chemistry 2001;276(21):18024-30.
2001: Peter Macheroux; O Seth; C Bollschweiler; M Schwarz; M Kurfürst; L C Au; Sandro Ghisla
L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma. Comparative sequence analysis and characterization of active and inactive forms of the enzyme.
European journal of biochemistry / FEBS 2001;268(6):1679-86.
2000: Stephan Umhau; Loredano Pollegioni; Gianluca Molla; Kay Diederichs; Wolfram Welte; Mirella S Pilone; Sandro Ghisla
The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12463-8.
2000: Kai Tittmann; Ralph Golbik; Sandro Ghisla; Gerhard Hübner
Mechanism of elementary catalytic steps of pyruvate oxidase from Lactobacillus plantarum.
Biochemistry 2000;39(35):10747-54.
2000: Peter D Pawelek; J Cheah; R Coulombe; Peter Macheroux; Sandro Ghisla; Alice Vrielink
The structure of L-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site.
The EMBO journal 2000;19(16):4204-15.
1999: Loredano Pollegioni; giovanni gadda; D Ambrosius; Sandro Ghisla; Mirella S Pilone
Cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum: effect of surfactants and organic solvents on activity.
Biotechnology and applied biochemistry 1999;30 ( Pt 1)():27-33.
1999: Loredano Pollegioni; G Wels; Mirella S Pilone; Sandro Ghisla
Kinetic mechanisms of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum.
European journal of biochemistry / FEBS 1999;264(1):140-51.
1999: S Hartmann; C Hultschig; W Eisenreich; G Fuchs; A Bacher; Sandro Ghisla
NIH shift in flavin-dependent monooxygenation: mechanistic studies with 2-aminobenzoyl-CoA monooxygenase/reductase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7831-6.
1999: B Küchler; A G Abdel-Ghany; Peter Bross; Andreas Nandy; I Rasched; Sandro Ghisla
Biochemical characterization of a variant human medium-chain acyl-CoA dehydrogenase with a disease-associated mutation localized in the active site.
The Biochemical journal 1999;337 ( Pt 2)():225-30.
1999: S Engst; P Vock; M Wang; J J Kim; Sandro Ghisla
Mechanism of activation of acyl-CoA substrates by medium chain acyl-CoA dehydrogenase: interaction of the thioester carbonyl with the flavin adenine dinucleotide ribityl side chain.
Biochemistry 1999;38(1):257-67.
1999: M Stehr; L Smau; M Singh; O Seth; Peter Macheroux; Sandro Ghisla; H Diekmann
Studies with lysine N6-hydroxylase. Effect of a mutation in the assumed FAD binding site on coenzyme affinities and on lysine hydroxylating activity.
Biological chemistry 1999;380(1):47-54.
1998: Heike Bömmel; Andreas Reif; Lothar G Fröhlich; Armin Frey; H Hofmann; D M Marecak; V Groehn; Peter Kotsonis; M La; S Köster; M Meinecke; M Bernhardt; M Weeger; Sandro Ghisla; G D Prestwich; Wolfgang Pfleiderer; Harald Schmidt
Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase.
The Journal of biological chemistry 1998;273(50):33142-9.
1998: S Köster; G Stier; N Kubasch; H C Curtius; Sandro Ghisla
Pterin-4a-carbinolamine dehydratase from Pseudomonas aeruginosa: characterization, catalytic mechanism and comparison to the human enzyme.
Biological chemistry 1998;379(12):1427-32.
1998: G J Mancini-Samuelson; V Kieweg; KM Sabaj; Sandro Ghisla; Marian T Stankovich
Redox properties of human medium-chain acyl-CoA dehydrogenase, modulation by charged active-site amino acid residues.
Biochemistry 1998;37(41):14605-12.
1998: Gerhard Hübner; Kai Tittmann; Margrit Killenberg-Jabs; J Schäffner; Michael Spinka; Holger Neef; Dorothee Kern; Gunther Kern; G Schneider; C Wikner; Sandro Ghisla
Activation of thiamin diphosphate in enzymes.
Biochimica et biophysica acta 1998;1385(2):221-8.
1998: I Rudik; Sandro Ghisla; Colin Thorpe
Protonic equilibria in the reductive half-reaction of the medium-chain acyl-CoA dehydrogenase.
Biochemistry 1998;37(23):8437-45.
1998: Kai Tittmann; D Proske; Michael Spinka; Sandro Ghisla; Rainer Rudolph; Gerhard Hübner; Gunther Kern
Activation of thiamin diphosphate and FAD in the phosphatedependent pyruvate oxidase from Lactobacillus plantarum.
The Journal of biological chemistry 1998;273(21):12929-34.
1998: P Vock; S Engst; M Eder; Sandro Ghisla
Substrate activation by acyl-CoA dehydrogenases: transition-state stabilization and pKs of involved functional groups.
Biochemistry 1998;37(7):1848-60.
1998: M Stehr; H Diekmann; L Smau; O Seth; Sandro Ghisla; M Singh; Peter Macheroux
A hydrophobic sequence motif common to N-hydroxylating enzymes.
Trends in biochemical sciences 1998;23(2):56-7.
1997: giovanni gadda; G Wels; Loredano Pollegioni; S Zucchelli; D Ambrosius; Mirella S Pilone; Sandro Ghisla
Characterization of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum.
European journal of biochemistry / FEBS 1997;250(2):369-76.
1997: Peter Macheroux; C Sanner; H Büttner; V Kieweg; Heinz Rüterjans; Sandro Ghisla
Medium-chain acyl CoA dehydrogenase: evidence for phosphorylation.
Biological chemistry 1997;378(11):1381-5.
1997: V Kieweg; F G Kräutle; Andreas Nandy; S Engst; P Vock; A G Abdel-Ghany; Peter Bross; N Gregersen; I Rasched; A Strauss; Sandro Ghisla
Biochemical characterization of purified, human recombinant Lys304-->Glu medium-chain acyl-CoA dehydrogenase containing the common disease-causing mutation and comparison with the normal enzyme.
European journal of biochemistry / FEBS 1997;246(2):548-56.
1997: M Eder; F Kräutle; Y Dong; P Vock; V Kieweg; J J Kim; A W Strauss; Sandro Ghisla
Characterization of human and pig kidney long-chain-acyl-CoA dehydrogenases and their role in beta-oxidation.
European journal of biochemistry / FEBS 1997;245(3):600-7.
1997: Loredano Pollegioni; W Blodig; Sandro Ghisla
On the mechanism of D-amino acid oxidase. Structure/linear free energy correlations and deuterium kinetic isotope effects using substituted phenylglycines.
The Journal of biological chemistry 1997;272(8):4924-34.
1996: S Köster; G Stier; Ralf Ficner; M Hölzer; H C Curtius; Dietrich Suck; Sandro Ghisla
Location of the active site and proposed catalytic mechanism of pterin-4a-carbinolamine dehydratase.
European journal of biochemistry / FEBS 1996;241(3):858-64.
1996: Peter Macheroux; Stephen Bornemann; Sandro Ghisla; Roger N F Thorneley
Studies with flavin analogs provide evidence that a protonated reduced FMN is the substrate-induced transient intermediate in the reaction of Escherichia coli chorismate synthase.
The Journal of biological chemistry 1996;271(42):25850-8.
1996: Andreas Nandy; V Kieweg; F G Kräutle; P Vock; B Küchler; Peter Bross; J J Kim; I Rasched; Sandro Ghisla
Medium-long-chain chimeric human Acyl-CoA dehydrogenase: medium-chain enzyme with the active center base arrangement of long-chain Acyl-CoA dehydrogenase.
Biochemistry 1996;35(38):12402-11.
1996: Andreas Nandy; B Küchler; Sandro Ghisla
Molecular evolution and substrate specificity of acyl-CoA dehydrogenases: chimaeric "medium/long' chain-specific enzyme from medium-chain acyl-CoA dehydrogenase.
Biochemical Society transactions 1996;24(1):105-10.
1995: S Köster; Beat Thöny; Peter Macheroux; H C Curtius; C W Heizmann; Wolfgang Pfleiderer; Sandro Ghisla
Human pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1 alpha. Characterization and kinetic analysis of wild-type and mutant enzymes.
European journal of biochemistry / FEBS 1995;231(2):414-23.
1995: B Langkau; Sandro Ghisla
Kinetic and mechanistic studies on the reactions of 2-aminobenzoyl-CoA monooxygenase/reductase.
European journal of biochemistry / FEBS 1995;230(2):686-97.
1995: B Langkau; P Vock; V Massey; G Fuchs; Sandro Ghisla
2-Aminobenzoyl-CoA monooxygenase/reductase. Evidence for two distinct loci catalyzing substrate monooxygenation and hydrogenation.
European journal of biochemistry / FEBS 1995;230(2):676-85.
1995: Peter Bross; C Jespersen; Thomas G Jensen; Brage S Andresen; M J Kristensen; Vibeke Winter; Andreas Nandy; F Kräutle; Sandro Ghisla; L Bolundi
Effects of two mutations detected in medium chain acyl-CoA dehydrogenase (MCAD)-deficient patients on folding, oligomer assembly, and stability of MCAD enzyme.
The Journal of biological chemistry 1995;270(17):10284-90.
1994: Peter Bross; Thomas G Jensen; Brage S Andresen; M Kjeldsen; Andreas Nandy; Steen Kølvraa; Sandro Ghisla; I Rasched; Lars Bolund; Niels Gregersen
Characterization of wild-type human medium-chain acyl-CoA dehydrogenase (MCAD) and mutant enzymes present in MCAD-deficient patients by two-dimensional gel electrophoresis: evidence for post-translational modification of the enzyme.
Biochemical medicine and metabolic biology 1994;52(1):36-44.
1993: Peter Macheroux; Sandro Ghisla; J Woodland Hastings
Spectral detection of an intermediate preceding the excited state in the bacterial luciferase reaction.
Biochemistry 1993;32(51):14183-6.
1993: Loredano Pollegioni; S Butò; W Tischer; Sandro Ghisla; Mirella S Pilone
Characterization of D-amino acid oxidase from Trigonopsis variabilis.
Biochemistry and molecular biology international 1993;31(4):709-17.
1993: Peter Bross; Brage S Andresen; Vibeke Winter; F Kräutle; Thomas G Jensen; Andreas Nandy; Steen Kølvraa; Sandro Ghisla; Lars Bolund; Niels Gregersen
Co-overexpression of bacterial GroESL chaperonins partly overcomes non-productive folding and tetramer assembly of E. coli-expressed human medium-chain acyl-CoA dehydrogenase (MCAD) carrying the prevalent disease-causing K304E mutation.
Biochimica et biophysica acta 1993;1182(3):264-74.
1993: Loredano Pollegioni; B Langkau; W Tischer; Sandro Ghisla; Mirella S Pilone
Kinetic mechanism of D-amino acid oxidases from Rhodotorula gracilis and Trigonopsis variabilis.
The Journal of biological chemistry 1993;268(19):13850-7.
1993: C R Hauer; I Rebrin; Beat Thöny; Frank Neuheiser; H C Curtius; Peter Hunziker; Nenad Blau; Sandro Ghisla; Claus W Heizmann
Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence.
The Journal of biological chemistry 1993;268(7):4828-31.
1993: J W Eckstein; J Woodland Hastings; Sandro Ghisla
Mechanism of bacterial bioluminescence: 4a,5-dihydroflavin analogs as models for luciferase hydroperoxide intermediates and the effect of substituents at the 8-position of flavin on luciferase kinetics.
Biochemistry 1993;32(2):404-11.
1993: I Rebrin; H C Curtius; Sandro Ghisla; Falko H Herrmann
Spectroscopic characterization of human liver pterin 4a-carbinolamine dehydratase.
Advances in experimental medicine and biology 1993;338():111-4.
1993: H C Curtius; Sandro Ghisla; H Hasegawa; Nenad Blau; I Rebrin
Progress in the study of biosynthesis and role of 7-substituted pterins: function of pterin-4a-carbinolamine dehydratase.
Advances in experimental medicine and biology 1993;338():107-10.
1992: Loredano Pollegioni; Sandro Ghisla; Mirella S Pilone
Studies on the active centre of Rhodotorula gracilis D-amino acid oxidase and comparison with pig kidney enzyme.
The Biochemical journal 1992;286 ( Pt 2)():389-94.
1992: C Adler; Sandro Ghisla; I Rebrin; J Haavik; Claus W Heizmann; Nenad Blau; T Kuster; H C Curtius
7-substituted pterins in humans with suspected pterin-4a-carbinolamine dehydratase deficiency. Mechanism of formation via non-enzymatic transformation from 6-substituted pterins.
European journal of biochemistry / FEBS 1992;208(1):139-44.
1992: A Schieber; R W Frank; Sandro Ghisla
Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase.
European journal of biochemistry / FEBS 1992;206(2):491-502.
1992: A Schieber; Sandro Ghisla
Prostaglandin 9-ketoreductase from pig and human kidney: purification, properties and identity with human carbonyl reductase.
Eicosanoids 1992;5 Suppl():S37-8.
1992: Peter Bross; T Jensen; F Kräutle; Vibeke Winter; Brage S Andresen; S Engst; Lars Bolund; Steen Kølvraa; Sandro Ghisla; I Rasched
Characterization of medium-chain acyl-CoA dehydrogenase (MCAD) with a point mutation associated with MCAD deficiency.
Progress in clinical and biological research 1992;375():473-8.
1992: Sandro Ghisla; S Engst; M Moll; Peter Bross; A W Strauss; J J Kim
Alpha, beta-dehydrogenation by acyl-CoA dehydrogenases: role of functional groups at the active center.
Progress in clinical and biological research 1992;375():127-42.
1992: C Adler; Sandro Ghisla; I Rebrin; Claus W Heizmann; Nenad Blau; H C Curtius
Suspected pterin-4a-carbinolamine dehydratase deficiency: hyperphenylalaninaemia due to inhibition of phenylalanine hydroxylase by tetrahydro-7-biopterin.
Journal of inherited metabolic disease 1992;15(3):405-8.
1992: H C Curtius; C Adler; Claus W Heizmann; Nenad Blau; I Rebrin; Sandro Ghisla
7-substituted pterins: formation and occurrence.
Journal of nutritional science and vitaminology 1992;Spec No():501-4.
1991: K Melde; S Jackson; K Bartlett; H S Sherratt; Sandro Ghisla
Metabolic consequences of methylenecyclopropylglycine poisoning in rats.
The Biochemical journal 1991;274 ( Pt 2)():395-400.
1991: Niels Gregersen; Brage S Andresen; Peter Bross; Vibeke Winter; N Rüdiger; S Engst; Sandro Ghisla; E Christensen; D Kelly; A W Strauss
Characterization of a disease-causing Lys329 to Glu mutation in 16 patients with medium-chain acyl-CoA dehydrogenase deficiency.
Journal of inherited metabolic disease 1991;14(3):314-6.
1990: H C Curtius; C Adler; I Rebrin; Claus W Heizmann; Sandro Ghisla
7-Substituted pterins: formation during phenylalanine hydroxylation in the absence of dehydratase.
Biochemical and biophysical research communications 1990;172(3):1060-6.
1990: B Langkau; Sandro Ghisla; R Buder; K Ziegler; G Fuchs
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Identification of the reaction products.
European journal of biochemistry / FEBS 1990;191(2):365-71.
1990: Peter Bross; S Engst; A W Strauss; D P Kelly; I Rasched; Sandro Ghisla
Characterization of wild-type and an active site mutant of human medium chain acyl-CoA dehydrogenase after expression in Escherichia coli.
The Journal of biological chemistry 1990;265(13):7116-9.
1990: Sandro Ghisla; T Kuster; P Steinerstauch; Walter Leimbacher; W J Richter; F Raschdorf; R Dahinden; H C Curtius
1H-NMR and mass spectrometric studies of tetrahydropterins. Evidence for the structure of 6-pyruvoyl tetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin.
European journal of biochemistry / FEBS 1990;187(3):651-6.
1990: J W Eckstein; K W Cho; Pio Colepicolo; Sandro Ghisla; J Woodland Hastings; T Wilson
A time-dependent bacterial bioluminescence emission spectrum in an in vitro single turnover system: energy transfer alone cannot account for the yellow emission of Vibrio fischeri Y-1.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1466-70.
1990: Sandro Ghisla; K Melde; H D Zeller; W Boschert
Mechanisms of enzyme inhibition by hypoglycin, methylenecyclopropylglycine and their metabolites.
Progress in clinical and biological research 1990;321():185-92.
1989: R Buder; K Ziegler; G Fuchs; B Langkau; Sandro Ghisla
2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Studies on the stoichiometry and the course of the reaction.
European journal of biochemistry / FEBS 1989;185(3):637-43.
1989: K Melde; H Buettner; W Boschert; H P Wolf; Sandro Ghisla
Mechanism of hypoglycaemic action of methylenecyclopropylglycine.
The Biochemical journal 1989;259(3):921-4.
1989: M Kurfürst; Peter Macheroux; Sandro Ghisla; J Woodland Hastings
Bioluminescence emission of bacterial luciferase with 1-deaza-FMN. Evidence for the noninvolvement of N(1)-protonated flavin species as emitters.
European journal of biochemistry / FEBS 1989;181(2):453-7.
1989: Sandro Ghisla; V Massey
Mechanisms of flavoprotein-catalyzed reactions.
European journal of biochemistry / FEBS 1989;181(1):1-17.
1987: Peter Macheroux; K U Schmidt; P Steinerstauch; Sandro Ghisla; Pio Colepicolo; R Buntic; J Woodland Hastings
Purification of the yellow fluorescent protein from Vibrio fischeri and identity of the flavin chromophore.
Biochemical and biophysical research communications 1987;146(1):101-6.
1986: S Takikawa; H C Curtius; U Redweik; Walter Leimbacher; Sandro Ghisla
Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver.
European journal of biochemistry / FEBS 1986;161(2):295-302.
1986: S Takikawa; H C Curtius; U Redweik; Sandro Ghisla
Purification of 6-pyruvoyl-tetrahydropterin synthase from human liver.
Biochemical and biophysical research communications 1986;134(2):646-51.
1985: H C Curtius; D Heintel; Sandro Ghisla; T Kuster; Walter Leimbacher; A Niederwieser
Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved.
European journal of biochemistry / FEBS 1985;148(3):413-9.
1985: H C Curtius; D Heintel; Sandro Ghisla; T Kuster; Walter Leimbacher; A Niederwieser
Biosynthesis of tetrahydrobiopterin in man.
Journal of inherited metabolic disease 1985;8 Suppl 1():28-33.
1984: M Kurfürst; Sandro Ghisla; J Woodland Hastings
Characterization and postulated structure of the primary emitter in the bacterial luciferase reaction.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(10):2990-4.
1984: Sandro Ghisla; R Mack; G Blankenhorn; P Hemmerich; E Krienitz; T Kuster
Structure of a novel flavin chromophore from Avena coleoptiles, the possible 'blue light' photoreceptor.
European journal of biochemistry / FEBS 1984;138(2):339-44.
1983: M Kurfürst; Sandro Ghisla; J Woodland Hastings
Bioluminescence emission from the reaction of luciferase-flavin mononucleotide radical with O2-..
Biochemistry 1983;22(7):1521-5.
1982: M Kurfürst; Sandro Ghisla; R Presswood; J Woodland Hastings
Structure and catalytic inactivity of the bacterial luciferase neutral flavin radical.
European journal of biochemistry / FEBS 1982;123(2):355-61.
1978: Sandro Ghisla; J Woodland Hastings; V Favaudon; J M Lhoste
Structure of the oxygen adduct intermediate in the bacterial luciferase reaction: C nuclear magnetic resonance determination.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(12):5860-3.