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Jorge Ghiso

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Anika Saul; Janaky Coomaraswamy; Jorge Ghiso; Janice Holton; Tammaryn Lashley; Tamas Revesz; Oliver Wirths
Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias.
Jose Morales-Corraliza; Thomas A Neubert; Ralph A Nixon; Mala V Rao; Matthias Staufenbiel; Jason D Berger; Jorge Ghiso; Matthew J Mazzella; Paul M Mathews
Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice.
Ge Zhou; Zefang Wang; Miguel A Alonso; Jorge Ghiso; Gert Kreibich; Feng-Xia Liang; Yi Liao; Jose L Luque-Garcia; Thomas A Neubert; Rok Romih; Nicole Schaeren-Wiemers; Tung-Tien Sun
MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.

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2013: Anika Saul; Janaky Coomaraswamy; Jorge Ghiso; Janice Holton; Tammaryn Lashley; Tamas Revesz; Oliver Wirths
Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias.
Neurobiology of aging 2013;34(5):1416-25.
2012: Jose Morales-Corraliza; Thomas A Neubert; Ralph A Nixon; Mala V Rao; Matthias Staufenbiel; Jason D Berger; Jorge Ghiso; Matthew J Mazzella; Paul M Mathews
Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice.
Neurobiology of aging 2012;33(6):1125.e9-18.
2012: Ge Zhou; Zefang Wang; Miguel A Alonso; Jorge Ghiso; Gert Kreibich; Feng-Xia Liang; Yi Liao; Jose L Luque-Garcia; Thomas A Neubert; Rok Romih; Nicole Schaeren-Wiemers; Tung-Tien Sun
MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells.
Molecular biology of the cell 2012;23(7):1354-66.
2012: Miguel Calero; Agueda Rostagno; Jorge Ghiso
Search for amyloid-binding proteins by affinity chromatography.
Methods in molecular biology (Clifton, N.J.) 2012;849():213-23.
2012: Silvia Fossati; Jorge Ghiso; Agueda Rostagno
Insights into caspase-mediated apoptotic pathways induced by amyloid-β in cerebral microvascular endothelial cells.
Neuro-degenerative diseases 2012;10(1-4):324-8.
2011: Maria Tsachaki; Vasiliki Zarkou; Andriana Fetani; Jorge Ghiso; Ismini Rozani; Despina Serlidaki; Spiros Efthimiopoulos
Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.
Glycobiology 2011;21(10):1382-8.
2010: Yang Hu; Baihao Su; Chung-Sei Kim; Michael Hernandez; Agueda Rostagno; Jorge Ghiso; Jin Ryoun Kim
A strategy for designing a peptide probe for detection of β-amyloid oligomers.
Chembiochem : a European journal of chemical biology 2010;11(17):2409-18.
2010: Mar Hernandez-Guillamon; Stephanie Mawhirt; Silvia Fossati; Steven Blais; Mireia Pares; Anna Penalba; Merce Boada; Pierre-Olivier Couraud; Thomas A Neubert; Joan Montaner; Jorge Ghiso; Agueda Rostagno
Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells.
The Journal of biological chemistry 2010;285(35):27144-58.
2010: Janaky Coomaraswamy; Ellen Kilger; Heidrun Wölfing; Claudia Schäfer; Stephan A Kaeser; Bettina M Wegenast-Braun; Jasmin K Hefendehl; Hartwig Wolburg; Matthew Mazzella; Jorge Ghiso; Michel Goedert; Haruhiko Akiyama; Francisco Garcia-Sierra; David P Wolfer; Paul Mathews; Mathias Jucker
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(17):7969-74.
2010: Yasushi Tomidokoro; Agueda Rostagno; Thomas A Neubert; Yun Lu; G William Rebeck; Blas Frangione; Steven M Greenberg; Jorge Ghiso
Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits.
The American journal of pathology 2010;176(4):1841-54.
2010: Agueda Rostagno; J L Holton; Tammaryn Lashley; Tamas Revesz; Jorge Ghiso
Cerebral amyloidosis: amyloid subunits, mutants and phenotypes.
Cellular and molecular life sciences : CMLS 2010;67(4):581-600.
2010: Matthew J Sharman; Michael Morici; Eugene Hone; Tamar Berger; Kevin Taddei; Ian J Martins; Wei Ling F Lim; Sajla Singh; Markus R Wenk; Jorge Ghiso; Joseph Buxbaum; Sam Gandy; Ralph N Martins
APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice.
Journal of Alzheimer's disease : JAD 2010;21(2):403-9.
2010: Matthew J Sharman; Guanghou Shui; Aaron Z Fernandis; Wei Ling F Lim; Tamar Berger; Eugene Hone; Kevin Taddei; Ian J Martins; Jorge Ghiso; Joseph Buxbaum; Sam Gandy; Markus R Wenk; Ralph N Martins
Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry.
Journal of Alzheimer's disease : JAD 2010;20(1):105-11.
2010: S Fossati; J Cam; J Meyerson; E Mezhericher; Ignacio Romero; P O Couraud; B B Weksler; Jorge Ghiso; Agueda Rostagno
Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(1):229-41.
2010: Maria Tsachaki; Jorge Ghiso; Agueda Rostagno; Spiros Efthimiopoulos
BRI2 homodimerizes with the involvement of intermolecular disulfide bonds.
Neurobiology of aging 2010;31(1):88-98.
2009: Agueda Rostagno; Jorge Ghiso
Isolation and biochemical characterization of amyloid plaques and paired helical filaments.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2009;Chapter 3():Unit 3.33 3.33.1-33.
2009: Markus Britschgi; C E Olin; H T Johns; Y Takeda-Uchimura; Melburne C Lemieux; K Rufibach; J Rajadas; Haiyu Zhang; Beren H Tomooka; William H Robinson; C M Clark; A M Fagan; Douglas Galasko; David M Holtzman; M Jutel; Jeffrey A Kaye; Cynthia A Lemere; J Leszek; G Li; Elaine Peskind; Joseph F Quinn; Jerome A Yesavage; Jorge Ghiso; Tony Wyss-Coray
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12145-50.
2009: Tamas Revesz; Janice L Holton; Tammaryn Lashley; Gordon Plant; Blas Frangione; Agueda Rostagno; Jorge Ghiso
Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies.
Acta neuropathologica 2009;118(1):115-30.
2009: R J S Viana; A F Nunes; Rui E Castro; Rita M Ramalho; J Meyerson; S Fossati; Jorge Ghiso; Agueda Rostagno; Cecília M P Rodrigues
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.
Cellular and molecular life sciences : CMLS 2009;66(6):1094-104.
2009: Raffaella Solito; Federico Corti; Silvia Fossati; Emiliya Mezhericher; Sandra Donnini; Jorge Ghiso; Antonio Giachetti; Agueda Rostagno; Marina Ziche
Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium.
Experimental cell research 2009;315(3):385-95.
2008: Maria Tsachaki; Jorge Ghiso; Spiros Efthimiopoulos
BRI2 as a central protein involved in neurodegeneration.
Biotechnology journal 2008;3(12):1548-54.
2008: Tammaryn Lashley; Tamas Revesz; Gordon Plant; R Bandopadhyay; Andrew J Lees; Blas Frangione; Nicholas W Wood; Rohan de Silva; Jorge Ghiso; Agueda Rostagno; Janice L Holton
Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.
Neuropathology and applied neurobiology 2008;34(5):492-505.
2008: Chih-Chi Andrew Hu; Thomas Bachmann; Ge Zhou; Feng-Xia Liang; Jorge Ghiso; Gert Kreibich; Tung-Tien Sun
Assembly of a membrane receptor complex: roles of the uroplakin II prosequence in regulating uroplakin bacterial receptor oligomerization.
The Biochemical journal 2008;414(2):195-203.
2008: Anne Berry; Yasushi Tomidokoro; Jorge Ghiso; Jan Thornton
Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-beta levels in female rats.
Hormones and behavior 2008;54(1):143-52.
2008: Agueda Rostagno; Jorge Ghiso
Preamyloid lesions and cerebrovascular deposits in the mechanism of dementia: lessons from non-beta-amyloid cerebral amyloidosis.
Neuro-degenerative diseases 2008;5(3-4):173-5.
2007: Agueda Rostagno; Tammaryn Lashley; Douglas Ng; Jordana Meyerson; Hans Braendgaard; Gordon Plant; Marie Bojsen-Møller; Janice Holton; Blas Frangione; Tamas Revesz; Jorge Ghiso
Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.
Journal of the neurological sciences 2007;257(1-2):88-96.
2007: Boris Ovodenko; Agueda Rostagno; Thomas A Neubert; Vivekananda Shetty; Stefani N Thomas; Austin Yang; Jeffrey M Liebmann; Jorge Ghiso; Robert Ritch
Proteomic analysis of exfoliation deposits.
Investigative ophthalmology & visual science 2007;48(4):1447-57.
2006: Tammaryn Lashley; Janice L Holton; Marcel M Verbeek; Agueda Rostagno; Marie Bojsen-Møller; Guido David; Jack van Horssen; Hans Braendgaard; Gordon Plant; Blas Frangione; Jorge Ghiso; Tamas Revesz
Molecular chaperons, amyloid and preamyloid lesions in the BRI2 gene-related dementias: a morphological study.
Neuropathology and applied neurobiology 2006;32(5):492-504.
2006: Melanie Meyer-Luehmann; Janaky Coomaraswamy; Tristan Bolmont; Stephan A Kaeser; Claudia Schaefer; Ellen Kilger; Anton Neuenschwander; Dorothee Abramowski; Peter Frey; Anneliese L Jaton; Jean-Marie Vigouret; Paolo Paganetti; Dominic M Walsh; Paul Mathews; Jorge Ghiso; Matthias Staufenbiel; Lary Walker; Mathias Jucker
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Science (New York, N.Y.) 2006;313(5794):1781-4.
2006: Troy L Carter; Steve Pedrini; Jorge Ghiso; Michelle E Ehrlich; Sam Gandy
Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis.
Neuroscience letters 2006;392(3):235-9.
2006: Jorge Ghiso; Agueda Rostagno; Yasushi Tomidokoro; Tammaryn Lashley; Marie Bojsen-Møller; Hans Braendgaard; Gordon Plant; Janice Holton; Ratneshwar Lal; Tamas Revesz; Blas Frangione
Genetic alterations of the BRI2 gene: familial British and Danish dementias.
Brain pathology (Zurich, Switzerland) 2006;16(1):71-9.
2005: Yasushi Tomidokoro; Tammaryn Lashley; Agueda Rostagno; Thomas A Neubert; Marie Bojsen-Møller; Hans Braendgaard; Gordon Plant; Janice Holton; Blas Frangione; Tamas Révész; Jorge Ghiso
Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.
The Journal of biological chemistry 2005;280(44):36883-94.
2005: Alberto Rábano; Adolfo Jiménez-Huete; Boris Acevedo; Miguel Calero; Jorge Ghiso; Israel Valdés; Jorge V. Gavilondo; Blas Frangione; Enrique Méndez
Diversity of senile plaques in Alzheimer's disease as revealed by a new monoclonal antibody that recognizes an internal sequence of the Abeta peptide.
Current Alzheimer research 2005;2(4):409-17.
2005: Angeliki Fotinopoulou; Maria Tsachaki; Maria Vlavaki; Alexandros Poulopoulos; Agueda Rostagno; Blas Frangione; Jorge Ghiso; Spiros Efthimiopoulos
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
The Journal of biological chemistry 2005;280(35):30768-72.
2005: Shuji Matsuda; Luca Giliberto; Yukiko Matsuda; Peter Davies; Eileen McGowan; Fiona Pickford; Jorge Ghiso; Blas Frangione; Luciano D'Adamio
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.
The Journal of biological chemistry 2005;280(32):28912-6.
2005: Agueda Rostagno; Yasushi Tomidokoro; Tammaryn Lashley; Douglas Ng; Gordon Plant; Janice Holton; Blas Frangione; Tamas Revesz; Jorge Ghiso
Chromosome 13 dementias.
Cellular and molecular life sciences : CMLS 2005;62(16):1814-25.
2005: arjan quist; Ivo Doudevski; Hai Lin; Rushana Azimova; Douglas Ng; Blas Frangione; Bruce L Kagan; Jorge Ghiso; Ratneshwar Lal
Amyloid ion channels: a common structural link for protein-misfolding disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10427-32.
2005: Laura Morelli; Ramiro E Llovera; Leonardo G Alonso; Blas Frangione; Gonzalo De Prat-Gay; Jorge Ghiso; Eduardo M Castaño
Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia.
Biochemical and biophysical research communications 2005;332(3):808-16.
2005: Miguel Calero; Jorge Ghiso
Radiolabeling of amyloid-beta peptides.
Methods in molecular biology (Clifton, N.J.) 2005;299():325-48.
2005: Miguel Calero; Agueda Rostagno; Blas Frangione; Jorge Ghiso
Clusterin and Alzheimer's disease.
Sub-cellular biochemistry 2005;38():273-98.
2004: Laura Morelli; Ramiro E Llovera; Irina Mathov; Lih-Fen Lue; Blas Frangione; Jorge Ghiso; Eduardo M Castaño
Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.
The Journal of biological chemistry 2004;279(53):56004-13.
2004: Jorge Ghiso; Marcos Shayo; Miguel Calero; Douglas Ng; Yasushi Tomidokoro; Sam Gandy; Agueda Rostagno; Blas Frangione
Systemic catabolism of Alzheimer's Abeta40 and Abeta42.
The Journal of biological chemistry 2004;279(44):45897-908.
2004: Jorge Ghiso; Thomas Wisniewski
An animal model of vascular amyloidosis.
Nature neuroscience 2004;7(9):902-4.
2004: Allison B Reiss; Keith A Siller; Mohammad M Rahman; Edwin S L Chan; Jorge Ghiso; Mony J de Leon
Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease.
Neurobiology of aging 2004;25(8):977-89.
2004: Etsuro Matsubara; Yoshiki Sekijima; Takahiko Tokuda; Katsuya Urakami; Masakuni Amari; Masami Shizuka-Ikeda; Yasushi Tomidokoro; Masaki Ikeda; Takeshi Kawarabayashi; Yasuo Harigaya; Shu-ichi Ikeda; Tetsuro Murakami; Koji Abe; Eiichi Otomo; Shunsaku Hirai; Blas Frangione; Jorge Ghiso; Mikio Shoji
Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins.
Neurobiology of aging 2004;25(7):833-41.
2003: Rekha Srinivasan; Eric M Jones; Keqian Liu; Jorge Ghiso; Roger E Marchant; Michael G Zagorski
pH-dependent amyloid and protofibril formation by the ABri peptide of familial British dementia.
Journal of molecular biology 2003;333(5):1003-23.
2003: Tamas Revesz; Jorge Ghiso; Tammaryn Lashley; Gordon Plant; Agueda Rostagno; Blas Frangione; Janice L Holton
Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view.
Journal of neuropathology and experimental neurology 2003;62(9):885-98.
2003: Rashid Deane; Shi Du Yan; Ram Kumar Submamaryan; Barbra LaRue; Suzana Jovanovic; Elizabeth Hogg; Deborah Welch; Lawrence Manness; Chang Lin; Jin Yu; Hong Zhu; Jorge Ghiso; Blas Frangione; Alan Stern; Ann Marie Schmidt; Don L Armstrong; Bernd Arnold; Birgit Liliensiek; Peter Nawroth; Florence M Hofman; Mark S Kindy; David M Stern; Berislav V Zlokovic
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Nature medicine 2003;9(7):907-13.
2003: Laura Morelli; Ramiro E Llovera; Silvia A Gonzalez; Jose L Affranchino; Frances Prelli; Blas Frangione; Jorge Ghiso; Eduardo M Castano
Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.
The Journal of biological chemistry 2003;278(26):23221-6.
2003: Etsuro Matsubara; Tara Bryant-Thomas; Javier Pacheco Quinto; Tracey L Henry; Burkhard Poeggeler; Donald Herbert; Felix Cruz-Sanchez; Yau-Jan Chyan; Mark A. Smith; George Perry; Mikio Shoji; Koji Abe; Anna Leone; Inge Grundke-Ikbal; Glenn L Wilson; Jorge Ghiso; Christina Williams; Lorenzo M Refolo; Miguel Pappolla; Daniel G Chain; Eyal Neria
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
Journal of neurochemistry 2003;85(5):1101-8.
2002: Agueda Rostagno; Tamas Revesz; Tammaryn Lashley; Yasushi Tomidokoro; Laura Magnotti; Hans Braendgaard; Gordon Plant; Marie Bojsen-Møller; Janice Holton; Blas Frangione; Jorge Ghiso
Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease.
The Journal of biological chemistry 2002;277(51):49782-90.
2002: Jorge Ghiso; Blas Frangione
Amyloidosis and Alzheimer's disease.
Advanced drug delivery reviews 2002;54(12):1539-51.
2002: E Matsubara; Mikio Shoji; T Murakami; Koji Abe; Blas Frangione; Jorge Ghiso
Platelet microparticles as carriers of soluble Alzheimer's amyloid beta (sAbeta).
Annals of the New York Academy of Sciences 2002;977():340-8.
2002: Agueda Rostagno; Glauco Frizzera; Lourdes R Ylagan; Asok Kumar; Jorge Ghiso; Gloria Gallo
Tumoral non-amyloidotic monoclonal immunoglobulin light chain deposits ('aggregoma'): presenting feature of B-cell dyscrasia in three cases with immunohistochemical and biochemical analyses.
British journal of haematology 2002;119(1):62-9.
2002: Zhongmin Zhou; Norman Richard Relkin; Jorge Ghiso; Jonathan D. Smith; Sam Gandy
Human cerebrospinal fluid apolipoprotein E isoforms are apparently inefficient at complexing with synthetic Alzheimer's amyloid-[beta] peptide (A[beta] 1-40 ) in vitro.
Molecular medicine (Cambridge, Mass.) 2002;8(7):376-81.
2002: Tamas Revesz; Janice L Holton; Tammaryn Lashley; Gordon Plant; Agueda Rostagno; Jorge Ghiso; Blas Frangione
Sporadic and familial cerebral amyloid angiopathies.
Brain pathology (Zurich, Switzerland) 2002;12(3):343-57.
2002: Jasmina B Mackic; James R Bading; Jorge Ghiso; Larry Walker; Thomas Wisniewski; Blas Frangione; Berislav V Zlokovic
Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.
Vascular pharmacology 2002;38(6):303-13.
2002: James R Bading; Shinya Yamada; Jasmina B Mackic; Linda Kirkman; Carol Miller; Miguel Calero; Jorge Ghiso; Blas Frangione; Berislav V Zlokovic
Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy.
Journal of drug targeting 2002;10(4):359-68.
2002: O R Monro; Jasmina B Mackic; Shinya Yamada; M B Segal; Jorge Ghiso; C Maurer; Miguel Calero; Blas Frangione; Berislav V Zlokovic
Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood.
Neurobiology of aging 2002;23(3):405-12.
2002: Janice L Holton; Tammaryn Lashley; Jorge Ghiso; Hans Braendgaard; Ruben Vidal; Christopher J Guerin; Graham Gibb; Diane P Hanger; Agueda Rostagno; Brian H Anderton; Catherine Strand; Hilary Ayling; Gordon Plant; Blas Frangione; Marie Bojsen-Møller; Tamas Revesz
Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
Journal of neuropathology and experimental neurology 2002;61(3):254-67.
2001: Burkhard Poeggeler; Leticia Miravalle; Michael G Zagorski; Thomas Wisniewski; Yau-Jan Chyan; Yanbin Zhang; H Shao; Tara Bryant-Thomas; Ruben Vidal; Blas Frangione; Jorge Ghiso; Miguel Pappolla
Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.
Biochemistry 2001;40(49):14995-5001.
2001: Jorge Ghiso; Tamas Révész; Janice Holton; Agueda Rostagno; Tammaryn Lashley; Henry Houlden; Graham Gibb; Brian H Anderton; T Bek; Marie Bojsen-Møller; Nicholas W Wood; Ruben Vidal; Hans Braendgaard; Gordon Plant; Blas Frangione
Chromosome 13 dementia syndromes as models of neurodegeneration.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8(4):277-84.
2001: Jorge Ghiso; Janice Holton; Leticia Miravalle; Miguel Calero; Tammaryn Lashley; Ruben Vidal; Henry Houlden; Nicholas W Wood; Thomas A Neubert; Agueda Rostagno; Gordon Plant; Tamas Revesz; Blas Frangione
Systemic amyloid deposits in familial British dementia.
The Journal of biological chemistry 2001;276(47):43909-14.
2001: Blas Frangione; Tamas Révész; Ruben Vidal; Janice Holton; Tammaryn Lashley; Henry Houlden; Nicholas W Wood; Agueda Rostagno; Gordon Plant; Jorge Ghiso
Familial cerebral amyloid angiopathy related to stroke and dementia.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8 Suppl 1():36-42.
2001: Miguel Pappolla; RA Omar; Yau-Jan Chyan; Jorge Ghiso; K Hsiao; Peter Bozner; George Perry; Mark A. Smith; Felix Cruz-Sanchez
Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".
Journal of neurochemistry 2001;78(1):121-8.
2001: Ruben Vidal; Miguel Calero; Tamas Révész; Gordon Plant; Jorge Ghiso; Blas Frangione
Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family.
Gene 2001;266(1-2):95-102.
2001: M H Teng; J Y Yin; Ruben Vidal; Jorge Ghiso; A Kumar; Rahmin Rabenou; A Shah; Daniel R Jacobson; Clement E Tagoe; Gloria Gallo; Joel Buxbaum
Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis.
Laboratory investigation; a journal of technical methods and pathology 2001;81(3):385-96.
2001: Janice L Holton; Jorge Ghiso; Tammaryn Lashley; Agueda Rostagno; C J Guerin; Graham Gibb; Henry Houlden; H Ayling; Lillian Martinian; Brian H Anderton; Nicholas W Wood; Ruben Vidal; Gordon Plant; Blas Frangione; Tamas Revesz
Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia.
The American journal of pathology 2001;158(2):515-26.
2000: M Shibata; Shinya Yamada; S R Kumar; Miguel Calero; James R Bading; Blas Frangione; David M Holtzman; C A Miller; Dudley K Strickland; Jorge Ghiso; Berislav V Zlokovic
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
The Journal of clinical investigation 2000;106(12):1489-99.
2000: Fusheng Chen; Dun-Sheng Yang; Suzana Petanceska; Austin Yang; Anurag Tandon; Gang G. Yu; Richard Rozmahel; Jorge Ghiso; M Nishimura; DM Zhang; Toshitaka Kawarai; Georges Levesque; J Mills; L Levesque; You-Qiang Song; Ekaterina Rogaeva; David Westaway; Howard T J Mount; Sam Gandy; Peter St George-Hyslop; Paul E Fraser
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
The Journal of biological chemistry 2000;275(47):36794-802.
2000: Ruben Vidal; Jorge Ghiso; Blas Frangione
New familial forms of cerebral amyloid and dementia.
Molecular psychiatry 2000;5(6):575-6.
2000: Leticia Miravalle; T Tokuda; Roberto Chiarle; G Giaccone; O Bugiani; Fabrizio Tagliavini; Blas Frangione; Jorge Ghiso
Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.
The Journal of biological chemistry 2000;275(35):27110-6.
2000: Miguel Calero; Agueda Rostagno; E Matsubara; Berislav V Zlokovic; Blas Frangione; Jorge Ghiso
Apolipoprotein J (clusterin) and Alzheimer's disease.
Microscopy research and technique 2000;50(4):305-15.
2000: Ruben Vidal; Miguel Calero; Pedro Piccardo; Martin R Farlow; Frederick W Unverzagt; Enrique Méndez; Adolfo Jiménez-Huete; Ronald C Beavis; G Gallo; E Gomez-Tortosa; Jorge Ghiso; Bradley T Hyman; Blas Frangione; Bernardino Ghetti
Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele.
Acta neuropathologica 2000;100(1):1-12.
2000: Berislav V Zlokovic; S Yamada; David M Holtzman; Jorge Ghiso; Blas Frangione
Clearance of amyloid beta-peptide from brain: transport or metabolism?
Nature medicine 2000;6(7):718-9.
2000: T Tokuda; Miguel Calero; E Matsubara; Ruben Vidal; Asok Kumar; Bruno Permanne; Berislav V Zlokovic; Jonathan D. Smith; Mary Jo Ladu; Agueda Rostagno; Blas Frangione; Jorge Ghiso
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.
The Biochemical journal 2000;348 Pt 2():359-65.
2000: simon mead; M James-Galton; Tamas Revesz; R B Doshi; G Harwood; E L Pan; Jorge Ghiso; Blas Frangione; Gordon Plant
Familial British dementia with amyloid angiopathy: early clinical, neuropsychological and imaging findings.
Brain : a journal of neurology 2000;123 ( Pt 5)():975-91.
2000: Ruben Vidal; Tamas Revesz; Agueda Rostagno; E Kim; J L Holton; T Bek; Marie Bojsen-Møller; Hans Braendgaard; Gordon Plant; Jorge Ghiso; Blas Frangione
A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4920-5.
2000: Jorge Ghiso; Ruben Vidal; Agueda Rostagno; simon mead; Tamas Révész; Gordon Plant; Blas Frangione
A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia.
Annals of the New York Academy of Sciences 2000;903():129-37.
2000: Valerie Askanas; W King Engel; RB Alvarez; Blas Frangione; Jorge Ghiso; Ruben Vidal
Inclusion body myositis, muscle blood vessel and cardiac amyloidosis, and transthyretin Val122Ile allele.
Annals of neurology 2000;47(4):544-9.
2000: Jorge Ghiso; Ruben Vidal; Agueda Rostagno; Leticia Miravalle; J L Holton; simon mead; Tamas Révész; Gordon Plant; Blas Frangione
Amyloidogenesis in familial British dementia is associated with a genetic defect on chromosome 13.
Annals of the New York Academy of Sciences 2000;920():84-92.
2000: Blas Frangione; Ruben Vidal; Agueda Rostagno; Jorge Ghiso
Familial cerebral amyloid angiopathies and dementia.
Alzheimer disease and associated disorders 2000;14 Suppl 1():S25-30.
2000: Miguel Pappolla; Yau-Jan Chyan; Burkhard Poeggeler; Blas Frangione; G Wilson; Jorge Ghiso; Russel J Reiter
An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(2):203-31.
2000: Nathalie Strazielle; Jean-François Ghersi-Egea; Jorge Ghiso; M P Dehouck; Blas Frangione; C Patlak; Joseph D Fenstermacher; P Gorevic
In vitro evidence that beta-amyloid peptide 1-40 diffuses across the blood-brain barrier and affects its permeability.
Journal of neuropathology and experimental neurology 2000;59(1):29-38.
1999: Agueda Rostagno; Ruben Vidal; B Kaplan; J Chuba; Asok Kumar; J I Elliott; Blas Frangione; Gloria Gallo; Jorge Ghiso
pH-dependent fibrillogenesis of a VkappaIII Bence Jones protein.
British journal of haematology 1999;107(4):835-43.
1999: Ruben Vidal; F Goñi; F Stevens; Pierre Aucouturier; Asok Kumar; Blas Frangione; Jorge Ghiso; Gloria Gallo
Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition.
The American journal of pathology 1999;155(6):2009-17.
1999: Miguel Calero; T Tokuda; Agueda Rostagno; Asok Kumar; Berislav V Zlokovic; Blas Frangione; Jorge Ghiso
Functional and structural properties of lipid-associated apolipoprotein J (clusterin).
The Biochemical journal 1999;344 Pt 2():375-83.
1999: Miguel Pappolla; Yau-Jan Chyan; Burkhard Poeggeler; Peter Bozner; Jorge Ghiso; Susan P LeDoux; Glenn L Wilson
Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin.
Journal of pineal research 1999;27(4):226-9.
1999: Batia Kaplan; Ruben Vidal; A Kumar; Jorge Ghiso; G Gallo
Immunochemical microanalysis of amyloid proteins in fine-needle aspirates of abdominal fat.
American journal of clinical pathology 1999;112(3):403-7.
1999: Yau-Jan Chyan; Burkhard Poeggeler; RA Omar; Daniel G Chain; Blas Frangione; Jorge Ghiso; Miguel Pappolla
Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid.
The Journal of biological chemistry 1999;274(31):21937-42.
1999: Ruben Vidal; Blas Frangione; Agueda Rostagno; simon mead; Tamas Révész; Gordon Plant; Jorge Ghiso
A stop-codon mutation in the BRI gene associated with familial British dementia.
Nature 1999;399(6738):776-81.
1999: Etsuro Matsubara; Jorge Ghiso; Blas Frangione; Masakuni Amari; Yasushi Tomidokoro; Yoshio Ikeda; Yasuo Harigaya; Koichi Okamoto; Mikio Shoji
Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome.
Annals of neurology 1999;45(4):537-41.
1999: Maria E Figueiredo-Pereira; Spiros Efthimiopoulos; Nikolaos Tezapsidis; A Buku; Jorge Ghiso; Pankaj Mehta; Nikolaos K Robakis
Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively.
Journal of neurochemistry 1999;72(4):1417-22.
1999: Jayne Raper; R Fung; Jorge Ghiso; Victor Nussenzweig; Stephen Tomlinson
Characterization of a novel trypanosome lytic factor from human serum.
Infection and immunity 1999;67(4):1910-6.
1998: Jasmina B Mackic; Monique F Stins; J Gordon McComb; Miguel Calero; Jorge Ghiso; Kwang S Kim; Shi Du Yan; David M Stern; Ann Marie Schmidt; Blas Frangione; Berislav V Zlokovic
Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.
The Journal of clinical investigation 1998;102(4):734-43.
1998: Marco Pizzolato; G Bragantini; P Bresciani; Santiago Pavlovsky; J Chuba; Ruben Vidal; Agueda Rostagno; Jorge Ghiso
IgG1-kappa biclonal gammopathy associated with multiple myeloma suggests a regulatory mechanism.
British journal of haematology 1998;102(2):503-8.
1998: Miguel Pappolla; Peter Bozner; C Soto; H Shao; Nikolaos K Robakis; Michael G Zagorski; Blas Frangione; Jorge Ghiso
Inhibition of Alzheimer beta-fibrillogenesis by melatonin.
The Journal of biological chemistry 1998;273(13):7185-8.
1998: Jasmina B Mackic; Martin H Weiss; W Miao; E Kirkman; Jorge Ghiso; Miguel Calero; James R Bading; Blas Frangione; Berislav V Zlokovic
Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy.
Journal of neurochemistry 1998;70(1):210-5.
1997: B Kaplan; Ruben Vidal; Asok Kumar; Jorge Ghiso; Blas Frangione; Gloria Gallo
Amino-terminal identity of co-existent amyloid and non-amyloid immunoglobulin kappa light chain deposits. A human disease to study alterations of protein conformation.
Clinical and experimental immunology 1997;110(3):472-8.
1997: C L Martel; Jasmina B Mackic; E Matsubara; S Governale; C Miguel; W Miao; J Gordon McComb; Blas Frangione; Jorge Ghiso; Berislav V Zlokovic
Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta.
Journal of neurochemistry 1997;69(5):1995-2004.
1997: Jorge Ghiso; Miguel Calero; E Matsubara; S Governale; J Chuba; Ronald C Beavis; Thomas Wisniewski; Blas Frangione
Alzheimer's soluble amyloid beta is a normal component of human urine.
FEBS letters 1997;408(1):105-8.
1997: Thomas Wisniewski; Jorge Ghiso; Blas Frangione
Biology of A beta amyloid in Alzheimer's disease.
Neurobiology of disease 1997;4(5):313-28.
1996: Agueda Rostagno; Ruben Vidal; Asok Kumar; J Chuba; G Niederman; L Gold; Blas Frangione; Jorge Ghiso; Gloria Gallo
Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1996;28(5):676-84.
1996: J González; F. Juarez Ramalho-Pinto; Ute Frevert; Jorge Ghiso; Stephen Tomlinson; J Scharfstein; EJ Corey; Victor Nussenzweig
Proteasome activity is required for the stage-specific transformation of a protozoan parasite.
The Journal of experimental medicine 1996;184(5):1909-18.
1996: Ruben Vidal; Jorge Ghiso; Thomas Wisniewski; Blas Frangione
Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant.
FEBS letters 1996;393(1):19-23.
1996: Jean-François Ghersi-Egea; P D Gorevic; Jorge Ghiso; Blas Frangione; C S Patlak; Joseph D Fenstermacher
Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries.
Journal of neurochemistry 1996;67(2):880-3.
1996: Alexei R Koudinov; Natalia V Koudinova; A Kumar; Ronald C Beavis; Jorge Ghiso
Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins.
Biochemical and biophysical research communications 1996;223(3):592-7.
1996: E Matsubara; C Soto; S Governale; Blas Frangione; Jorge Ghiso
Apolipoprotein J and Alzheimer's amyloid beta solubility.
The Biochemical journal 1996;316 ( Pt 2)():671-9.
1996: Gloria Gallo; F Goñi; F Boctor; Ruben Vidal; Asok Kumar; F J Stevens; Blas Frangione; Jorge Ghiso
Light chain cardiomyopathy. Structural analysis of the light chain tissue deposits.
The American journal of pathology 1996;148(5):1397-406.
1996: Berislav V Zlokovic; C L Martel; E Matsubara; J Gordon McComb; G Zheng; R T McCluskey; Blas Frangione; Jorge Ghiso
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4229-34.
1996: C L Martel; Jasmina B Mackic; J Gordon McComb; Jorge Ghiso; Berislav V Zlokovic
Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs.
Neuroscience letters 1996;206(2-3):157-60.
1996: M H Baumann; Thomas Wisniewski; Efrat Levy; G T Plant; Jorge Ghiso
C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type.
Biochemical and biophysical research communications 1996;219(1):238-42.
1996: Blas Frangione; Eduardo M Castaño; Thomas Wisniewski; Jorge Ghiso; F Prelli; Ruben Vidal
Apolipoprotein E and amyloidogenesis.
Ciba Foundation symposium 1996;199():132-41; discussion 141-5.
1996: Giorgio Giaccone; B Pedrotti; antonio migheli; L Verga; J Perez; G Racagni; Mark A. Smith; George Perry; Luca De Gioia; C Selvaggini; Mario Salmona; Jorge Ghiso; Blas Frangione; K Islam; Orso Bugiani; Fabrizio Tagliavini
beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.
The American journal of pathology 1996;148(1):79-87.
1995: Thomas Wisniewski; Joana Almeida Palha; Jorge Ghiso; Blas Frangione
S182 protein in Alzheimer's disease neuritic plaques.
Lancet 1995;346(8986):1366.
1995: Mark A. Smith; Sandra L Siedlak; P L Richey; P Mulvihill; Jorge Ghiso; Blas Frangione; F Tagliavini; G Giaccone; O Bugiani; D Praprotnik
Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease.
Nature medicine 1995;1(4):365-9.
1995: E Matsubara; Blas Frangione; Jorge Ghiso
Characterization of apolipoprotein J-Alzheimer's A beta interaction.
The Journal of biological chemistry 1995;270(13):7563-7.
1995: Jorge Ghiso; G T Plant; T Révész; Thomas Wisniewski; Blas Frangione
Familial cerebral amyloid angiopathy (British type) with nonneuritic amyloid plaque formation may be due to a novel amyloid protein.
Journal of the neurological sciences 1995;129(1):74-5.
1995: Stephen Tomlinson; Ana Maria Jansen; Alexei R Koudinov; Jorge Ghiso; N H Choi-Miura; M R Rifkin; S Ohtaki; Victor Nussenzweig
High-density-lipoprotein-independent killing of Trypanosoma brucei by human serum.
Molecular and biochemical parasitology 1995;70(1-2):131-8.
1994: Berislav V Zlokovic; C L Martel; Jasmina B Mackic; E Matsubara; Thomas Wisniewski; J Gordon McComb; Blas Frangione; Jorge Ghiso
Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta.
Biochemical and biophysical research communications 1994;205(2):1431-7.
1994: Alexei R Koudinov; E Matsubara; Blas Frangione; Jorge Ghiso
The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma.
Biochemical and biophysical research communications 1994;205(2):1164-71.
1994: Tero Kivelä; Ahti Tarkkanen; Blas Frangione; Jorge Ghiso; Matti Haltia
Ocular amyloid deposition in familial amyloidosis, Finnish: an analysis of native and variant gelsolin in Meretoja's syndrome.
Investigative ophthalmology & visual science 1994;35(10):3759-69.
1994: Gloria Gallo; Thomas Wisniewski; N H Choi-Miura; Jorge Ghiso; Blas Frangione
Potential role of apolipoprotein-E in fibrillogenesis.
The American journal of pathology 1994;145(3):526-30.
1994: Jorge Ghiso; J E Gardella; L Liem; P D Gorevic; Blas Frangione
Characterization of a novel processing pathway for Alzheimer's amyloid beta precursor protein.
Neuroscience letters 1994;171(1-2):213-6.
1994: Thomas Wisniewski; Jorge Ghiso; Blas Frangione
Alzheimer's disease and soluble A beta.
Neurobiology of aging 1994;15(2):143-52.
1994: Jorge Ghiso; Thomas Wisniewski; Blas Frangione
Unifying features of systemic and cerebral amyloidosis.
Molecular neurobiology 1994;8(1):49-64.
1994: Blas Frangione; Thomas Wisniewski; Jorge Ghiso
Chaperoning Alzheimer's amyloids.
Neurobiology of aging 1994;15 Suppl 2():S97-9.
1993: Berislav V Zlokovic; Jorge Ghiso; Jasmina B Mackic; J Gordon McComb; M H Weiss; Blas Frangione
Blood-brain barrier transport of circulating Alzheimer's amyloid beta.
Biochemical and biophysical research communications 1993;197(3):1034-40.
1993: Tero Kivelä; Ahti Tarkkanen; I McLean; Jorge Ghiso; Blas Frangione; Matti Haltia
Immunohistochemical analysis of lattice corneal dystrophies types I and II.
The British journal of ophthalmology 1993;77(12):799-804.
1993: Thomas Wisniewski; E Castano; Jorge Ghiso; Blas Frangione
Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.
Annals of neurology 1993;34(4):631-3.
1993: J E Gardella; G A Gorgone; L Candela; Jorge Ghiso; Eduardo M Castaño; Blas Frangione; P D Gorevic
High-level expression and in vitro mutagenesis of a fibrillogenic 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein.
The Biochemical journal 1993;294 ( Pt 3)():667-74.
1993: Jorge Ghiso; E Matsubara; Alexei R Koudinov; N H Choi-Miura; M Tomita; Thomas Wisniewski; Blas Frangione
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
The Biochemical journal 1993;293 ( Pt 1)():27-30.
1993: Lev G Goldfarb; Paul Brown; Matti Haltia; Jorge Ghiso; Blas Frangione; D Carleton Gajdusek
Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4451-4.
1993: Thomas Wisniewski; Adam A Golabek; E Matsubara; Jorge Ghiso; Blas Frangione
Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid.
Biochemical and biophysical research communications 1993;192(2):359-65.
1993: T V Ramabhadran; Sam Gandy; Jorge Ghiso; Andrew J Czernik; D Ferris; R Bhasin; Dmitry Goldgaber; Blas Frangione; Paul Greengard
Proteolytic processing of human amyloid beta protein precursor in insect cells. Major carboxyl-terminal fragment is identical to its human counterpart.
The Journal of biological chemistry 1993;268(3):2009-12.
1992: Jorge Ghiso; Agueda Rostagno; J E Gardella; L Liem; P D Gorevic; Blas Frangione
A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.
The Biochemical journal 1992;288 ( Pt 3)():1053-9.
1992: Mikio Shoji; todd golde; Jorge Ghiso; T T Cheung; Steven Estus; L M Shaffer; X D Cai; D M McKay; R Tintner; Blas Frangione
Production of the Alzheimer amyloid beta protein by normal proteolytic processing.
Science (New York, N.Y.) 1992;258(5079):126-9.
1992: Ruben Vidal; Jorge Ghiso; G Gallo; M Cohen; P L Gambetti; Blas Frangione
Amyloidoma of the CNS. II. Immunohistochemical and biochemical study.
Neurology 1992;42(10):2024-8.
1992: J E Gardella; G A Gorgone; P C Munoz; Jorge Ghiso; Blas Frangione; P D Gorevic
Beta protein precursor expression in human platelets and a megakaryocyte cell line. Possible implications for the origin of cerebral amyloidosis in Alzheimer's disease.
Laboratory investigation; a journal of technical methods and pathology 1992;67(3):303-13.
1992: Jorge Ghiso; Thomas Wisniewski; Ruben Vidal; Agueda Rostagno; Blas Frangione
Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease.
The Biochemical journal 1992;282 ( Pt 2)():517-22.
1992: F Coria; A Moreno; A Torres; I Ahmad; Jorge Ghiso
Distribution of Alzheimer's disease amyloid protein precursor in normal human and rat nervous system.
Neuropathology and applied neurobiology 1992;18(1):27-35.
1991: P D Gorevic; P C Munoz; G Gorgone; J J Purcell; M Rodrigues; Jorge Ghiso; Efrat Levy; M Haltia; Blas Frangione
Amyloidosis due to a mutation of the gelsolin gene in an American family with lattice corneal dystrophy type II.
The New England journal of medicine 1991;325(25):1780-5.
1991: A P Kuruvilla; G M Hochwald; Jorge Ghiso; Eduardo M Castaño; M Pizzolato; Blas Frangione
Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid.
Brain research 1991;565(2):337-40.
1991: Thomas Wisniewski; Jorge Ghiso; Blas Frangione
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;180(3):1528.
1991: Thomas Wisniewski; Jorge Ghiso; Blas Frangione
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;179(3):1247-54.
1991: Fabrizio Tagliavini; Giorgio Giaccone; L Verga; Jorge Ghiso; Blas Frangione; Orso Bugiani
Alzheimer patients: preamyloid deposits are immunoreactive with antibodies to extracellular domains of the amyloid precursor protein.
Neuroscience letters 1991;128(1):117-20.
1991: Matti Haltia; Jorge Ghiso; Thomas Wisniewski; S Kiuru; D Miller; Blas Frangione
Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies.
Neurobiology of aging 1991;12(4):313-6.
1991: Thomas Wisniewski; Matti Haltia; Jorge Ghiso; Blas Frangione
Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type.
The American journal of pathology 1991;138(5):1077-83.
1991: Fabrizio Tagliavini; F Prelli; Jorge Ghiso; Orso Bugiani; D Serban; Stanley B Prusiner; Martin R Farlow; Bernardino Ghetti; Blas Frangione
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
The EMBO journal 1991;10(3):513-9.
1991: J Leoni; Jorge Ghiso; F Goñi; Blas Frangione
The primary structure of the Fab fragment of protein KAU, a monoclonal immunoglobulin M cold agglutinin.
The Journal of biological chemistry 1991;266(5):2836-42.
1990: J E Gardella; Jorge Ghiso; G A Gorgone; D Marratta; A P Kaplan; Blas Frangione; P D Gorevic
Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA.
Biochemical and biophysical research communications 1990;173(3):1292-8.
1990: Jorge Ghiso; Matti Haltia; F Prelli; J Novello; Blas Frangione
Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.
The Biochemical journal 1990;272(3):827-30.
1990: Efrat Levy; Matti Haltia; I Fernandez-Madrid; O Koivunen; Jorge Ghiso; F Prelli; Blas Frangione
Mutation in gelsolin gene in Finnish hereditary amyloidosis.
The Journal of experimental medicine 1990;172(6):1865-7.
1990: Sérgio Marangoni; Jorge Ghiso; Suely V Sampaio; Eliane C Arantes; José R Giglio; B Oliveira; Blas Frangione
The complete amino acid sequence of toxin TsTX-VI isolated from the venom of the scorpion Tityus serrulatus.
Journal of protein chemistry 1990;9(5):595-601.
1990: Matti Haltia; Jorge Ghiso; F Prelli; Gloria Gallo; S Kiuru; Hannu Somer; Jukka U Palo; Blas Frangione
Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin.
The American journal of pathology 1990;136(6):1223-8.
1990: Fabrizio Tagliavini; Jorge Ghiso; W F Timmers; G Giaccone; O Bugiani; Blas Frangione
Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls.
Laboratory investigation; a journal of technical methods and pathology 1990;62(6):761-7.
1990: Matti Haltia; F Prelli; Jorge Ghiso; S Kiuru; Hannu Somer; Jukka U Palo; Blas Frangione
Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein.
Biochemical and biophysical research communications 1990;167(3):927-32.
1990: Jorge Ghiso; E Saball; J Leoni; Agueda Rostagno; Blas Frangione
Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1288-91.
1989: Jorge Ghiso; Fabrizio Tagliavini; W F Timmers; Blas Frangione
Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization.
Biochemical and biophysical research communications 1989;163(1):430-7.
1989: D C Gowda; RK Margolis; Blas Frangione; Jorge Ghiso; M Larrondo-Lillo; Richard U Margolis
Relation of the amyloid beta protein precursor to heparan sulfate proteoglycans.
Science (New York, N.Y.) 1989;244(4906):826-8.
1989: Efrat Levy; C Lopez-Otin; Jorge Ghiso; D Geltner; Blas Frangione
Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases.
The Journal of experimental medicine 1989;169(5):1771-8.
1988: Jorge Ghiso; N Cowan; Blas Frangione
Isolation of a sequence encoding human cystatin C. Conservation of exon-intron structure between members of the cysteine proteinase inhibitors superfamily.
Biological chemistry Hoppe-Seyler 1988;369 Suppl():205-8.
1987: A H Warfel; Dorothea Zucker-Franklin; Blas Frangione; Jorge Ghiso
Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation.
The Journal of experimental medicine 1987;166(6):1912-7.
1987: Eduardo M Castaño; Jorge Ghiso; Blas Frangione
[Amyloidosis of the central nervous system].
Medicina 1987;47(5):534-42.
1986: Eduardo M Castaño; Jorge Ghiso; F Prelli; P D Gorevic; antonio migheli; Blas Frangione
In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein.
Biochemical and biophysical research communications 1986;141(2):782-9.
1986: Jorge Ghiso; O Jensson; Blas Frangione
Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C).
Proceedings of the National Academy of Sciences of the United States of America 1986;83(9):2974-8.
1986: Jorge Ghiso; B Pons-Estel; Blas Frangione
Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases.
Biochemical and biophysical research communications 1986;136(2):548-54.
1986: Jorge Ghiso; Alan Solomon; Blas Frangione
Association of human lambda light chain V/J/C segments: serologic analysis and primary structure of the lambda VI Bence Jones protein THO.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(2):716-9.