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Jorge Ghiso

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Tsachaki Maria; Ghiso Jorge; Rostagno Agueda; Efthimiopoulos Spiros
BRI2 homodimerizes with the involvement of intermolecular disulfide bonds.
Rostagno Agueda; Ghiso Jorge
Isolation and biochemical characterization of amyloid plaques and paired helical filaments.
Britschgi M; Olin C E; Johns H T; Takeda-Uchimura Y; LeMieux M C; Rufibach K; Rajadas J; Zhang H; Tomooka B; Robinson W H; Clark C M; Fagan A M; Galasko D R; Holtzman D M; Jutel M; Kaye J A; Lemere C A; Leszek J; Li G; Peskind E R; Quinn J F; Yesavage J A; Ghiso J A; Wyss-Coray T
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.

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All Publications

2010: Tsachaki Maria; Ghiso Jorge; Rostagno Agueda; Efthimiopoulos Spiros
BRI2 homodimerizes with the involvement of intermolecular disulfide bonds.
Neurobiology of aging 2010;31(1):88-98.
2009: Rostagno Agueda; Ghiso Jorge
Isolation and biochemical characterization of amyloid plaques and paired helical filaments.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2009;Chapter 3():Unit 3.33 3.33.1-33.
2009: Britschgi M; Olin C E; Johns H T; Takeda-Uchimura Y; LeMieux M C; Rufibach K; Rajadas J; Zhang H; Tomooka B; Robinson W H; Clark C M; Fagan A M; Galasko D R; Holtzman D M; Jutel M; Kaye J A; Lemere C A; Leszek J; Li G; Peskind E R; Quinn J F; Yesavage J A; Ghiso J A; Wyss-Coray T
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12145-50.
2009: Revesz Tamas; Holton Janice L; Lashley Tammaryn; Plant Gordon; Frangione Blas; Rostagno Agueda; Ghiso Jorge
Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies.
Acta neuropathologica 2009;118(1):115-30.
2009: Viana R J S; Nunes A F; Castro R E; Ramalho R M; Meyerson J; Fossati S; Ghiso J; Rostagno A; Rodrigues C M P
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.
Cellular and molecular life sciences : CMLS 2009;66(6):1094-104.
2009: Solito Raffaella; Corti Federico; Fossati Silvia; Mezhericher Emiliya; Donnini Sandra; Ghiso Jorge; Giachetti Antonio; Rostagno Agueda; Ziche Marina
Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium.
Experimental cell research 2009;315(3):385-95.
2008: Tsachaki Maria; Ghiso Jorge; Efthimiopoulos Spiros
BRI2 as a central protein involved in neurodegeneration.
Biotechnology journal 2008;3(12):1548-54.
2008: Lashley T; Revesz T; Plant G; Bandopadhyay R; Lees A J; Frangione B; Wood N W; de Silva R; Ghiso J; Rostagno A; Holton J L
Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.
Neuropathology and applied neurobiology 2008;34(5):492-505.
2008: Hu Chih-Chi Andrew; Bachmann Thomas; Zhou Ge; Liang Feng-Xia; Ghiso Jorge; Kreibich Gert; Sun Tung-Tien
Assembly of a membrane receptor complex: roles of the uroplakin II prosequence in regulating uroplakin bacterial receptor oligomerization.
The Biochemical journal 2008;414(2):195-203.
2008: Berry Anne; Tomidokoro Yasushi; Ghiso Jorge; Thornton Jan
Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-beta levels in female rats.
Hormones and behavior 2008;54(1):143-52.
2008: Rostagno Agueda; Ghiso Jorge
Preamyloid lesions and cerebrovascular deposits in the mechanism of dementia: lessons from non-beta-amyloid cerebral amyloidosis.
Neuro-degenerative diseases 2008;5(3-4):173-5.
2007: Rostagno Agueda; Lashley Tammaryn; Ng Douglas; Meyerson Jordana; Braendgaard Hans; Plant Gordon; Bojsen-Møller Marie; Holton Janice; Frangione Blas; Revesz Tamas; Ghiso Jorge
Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.
Journal of the neurological sciences 2007;257(1-2):88-96.
2007: Ovodenko Boris; Rostagno Agueda; Neubert Thomas A; Shetty Vivekananda; Thomas Stefani; Yang Austin; Liebmann Jeffrey; Ghiso Jorge; Ritch Robert
Proteomic analysis of exfoliation deposits.
Investigative ophthalmology & visual science 2007;48(4):1447-57.
2006: Lashley T; Holton J L; Verbeek M M; Rostagno A; Bojsen-Møller M; David G; van Horssen J; Braendgaard H; Plant G; Frangione B; Ghiso J; Revesz T
Molecular chaperons, amyloid and preamyloid lesions in the BRI2 gene-related dementias: a morphological study.
Neuropathology and applied neurobiology 2006;32(5):492-504.
2006: Meyer-Luehmann Melanie; Coomaraswamy Janaky; Bolmont Tristan; Kaeser Stephan; Schaefer Claudia; Kilger Ellen; Neuenschwander Anton; Abramowski Dorothee; Frey Peter; Jaton Anneliese L; Vigouret Jean-Marie; Paganetti Paolo; Walsh Dominic M; Mathews Paul M; Ghiso Jorge; Staufenbiel Matthias; Walker Lary C; Jucker Mathias
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Science (New York, N.Y.) 2006;313(5794):1781-4.
2006: Ghiso J; Rostagno A; Tomidokoro Y; Lashley T; Bojsen-Møller M; Braendgaard H; Plant G; Holton J; Lal R; Revesz T; Frangione B
Genetic alterations of the BRI2 gene: familial British and Danish dementias.
Brain pathology (Zurich, Switzerland) 2006;16(1):71-9.
2006: Carter Troy L; Pedrini Steve; Ghiso Jorge; Ehrlich Michelle E; Gandy Sam
Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis.
Neuroscience letters 2006;392(3):235-9.
2005: Tomidokoro Yasushi; Lashley Tammaryn; Rostagno Agueda; Neubert Thomas A; Bojsen-Møller Marie; Braendgaard Hans; Plant Gordon; Holton Janice; Frangione Blas; Révész Tamas; Ghiso Jorge
Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.
The Journal of biological chemistry 2005;280(44):36883-94.
2005: Rábano Alberto; Jiménez-Huete Adolfo; Acevedo Boris; Calero Miguel; Ghiso Jorge; Valdés Israel; Gavilondo Jorge; Frangione Blas; Méndez Enrique
Diversity of senile plaques in Alzheimer's disease as revealed by a new monoclonal antibody that recognizes an internal sequence of the Abeta peptide.
Current Alzheimer research 2005;2(4):409-17.
2005: Fotinopoulou Angeliki; Tsachaki Maria; Vlavaki Maria; Poulopoulos Alexandros; Rostagno Agueda; Frangione Blas; Ghiso Jorge; Efthimiopoulos Spiros
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
The Journal of biological chemistry 2005;280(35):30768-72.
2005: Matsuda Shuji; Giliberto Luca; Matsuda Yukiko; Davies Peter; McGowan Eileen; Pickford Fiona; Ghiso Jorge; Frangione Blas; D'Adamio Luciano
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.
The Journal of biological chemistry 2005;280(32):28912-6.
2005: Rostagno A; Tomidokoro Y; Lashley T; Ng D; Plant G; Holton J; Frangione B; Revesz T; Ghiso J
Chromosome 13 dementias.
Cellular and molecular life sciences : CMLS 2005;62(16):1814-25.
2005: Quist Arjan; Doudevski Ivo; Lin Hai; Azimova Rushana; Ng Douglas; Frangione Blas; Kagan Bruce; Ghiso Jorge; Lal Ratnesh
Amyloid ion channels: a common structural link for protein-misfolding disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10427-32.
2005: Morelli Laura; Llovera Ramiro E; Alonso Leonardo G; Frangione Blas; de Prat-Gay Gonzalo; Ghiso Jorge; Castaño Eduardo M
Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia.
Biochemical and biophysical research communications 2005;332(3):808-16.
2005: Calero Miguel; Ghiso Jorge
Radiolabeling of amyloid-beta peptides.
Methods in molecular biology (Clifton, N.J.) 2005;299():325-48.
2005: Calero Miguel; Rostagno Agueda; Frangione Blas; Ghiso Jorge
Clusterin and Alzheimer's disease.
Sub-cellular biochemistry 2005;38():273-98.
2004: Morelli Laura; Llovera Ramiro E; Mathov Irina; Lue Lih-Fen; Frangione Blas; Ghiso Jorge; Castaño Eduardo M
Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.
The Journal of biological chemistry 2004;279(53):56004-13.
2004: Ghiso Jorge; Shayo Marcos; Calero Miguel; Ng Douglas; Tomidokoro Yasushi; Gandy Samuel; Rostagno Agueda; Frangione Blas
Systemic catabolism of Alzheimer's Abeta40 and Abeta42.
The Journal of biological chemistry 2004;279(44):45897-908.
2004: Ghiso Jorge; Wisniewski Thomas
An animal model of vascular amyloidosis.
Nature neuroscience 2004;7(9):902-4.
2004: Reiss Allison B; Siller Keith A; Rahman Mohammad M; Chan Edwin S L; Ghiso Jorge; de Leon Mony J
Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease.
Neurobiology of aging 2004;25(8):977-89.
2004: Matsubara Etsuro; Sekijima Yoshiki; Tokuda Takahiko; Urakami Katsuya; Amari Masakuni; Shizuka-Ikeda Masami; Tomidokoro Yasushi; Ikeda Masaki; Kawarabayashi Takeshi; Harigaya Yasuo; Ikeda Shu-ichi; Murakami Tetsuro; Abe Koji; Otomo Eiichi; Hirai Shunsaku; Frangione Blas; Ghiso Jorge; Shoji Mikio
Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins.
Neurobiology of aging 2004;25(7):833-41.
2003: Srinivasan Rekha; Jones Eric M; Liu Keqian; Ghiso Jorge; Marchant Roger E; Zagorski Michael G
pH-dependent amyloid and protofibril formation by the ABri peptide of familial British dementia.
Journal of molecular biology 2003;333(5):1003-23.
2003: Revesz Tamas; Ghiso Jorge; Lashley Tammaryn; Plant Gordon; Rostagno Agueda; Frangione Blas; Holton Janice L
Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view.
Journal of neuropathology and experimental neurology 2003;62(9):885-98.
2003: Deane Rashid; Du Yan Shi; Submamaryan Ram Kumar; LaRue Barbara; Jovanovic Suzana; Hogg Elizabeth; Welch Deborah; Manness Lawrence; Lin Chang; Yu Jin; Zhu Hong; Ghiso Jorge; Frangione Blas; Stern Alan; Schmidt Ann Marie; Armstrong Don L; Arnold Bernd; Liliensiek Birgit; Nawroth Peter; Hofman Florence; Kindy Mark; Stern David; Zlokovic Berislav
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Nature medicine 2003;9(7):907-13.
2003: Matsubara Etsuro; Bryant-Thomas Tara; Pacheco Quinto Javier; Henry Tracey L; Poeggeler Burkhard; Herbert Donald; Cruz-Sanchez Felix; Chyan Yau-Jan; Smith Mark A; Perry George; Shoji Mikio; Abe Koji; Leone Anna; Grundke-Ikbal Inge; Wilson Glen L; Ghiso Jorge; Williams Christina; Refolo Lorenzo M; Pappolla Miguel A; Chain Daniel G; Neria Eyal
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
Journal of neurochemistry 2003;85(5):1101-8.
2003: Morelli Laura; Llovera Ramiro; Gonzalez Silvia A; Affranchino Jose L; Prelli Frances; Frangione Blas; Ghiso Jorge; Castano Eduardo M
Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.
The Journal of biological chemistry 2003;278(26):23221-6.
2002: Ghiso Jorge; Frangione Blas
Amyloidosis and Alzheimer's disease.
Advanced drug delivery reviews 2002;54(12):1539-51.
2002: Rostagno Agueda; Revesz Tamas; Lashley Tammaryn; Tomidokoro Yasushi; Magnotti Laura; Braendgaard Hans; Plant Gordon; Bojsen-Møller Marie; Holton Janice; Frangione Blas; Ghiso Jorge
Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease.
The Journal of biological chemistry 2002;277(51):49782-90.
2002: Matsubara E; Shoji M; Murakami T; Abe K; Frangione B; Ghiso J
Platelet microparticles as carriers of soluble Alzheimer's amyloid beta (sAbeta).
Annals of the New York Academy of Sciences 2002;977():340-8.
2002: Rostagno Agueda; Frizzera Glauco; Ylagan Lourdes; Kumar Asok; Ghiso Jorge; Gallo Gloria
Tumoral non-amyloidotic monoclonal immunoglobulin light chain deposits ('aggregoma'): presenting feature of B-cell dyscrasia in three cases with immunohistochemical and biochemical analyses.
British journal of haematology 2002;119(1):62-9.
2002: Zhou Zhongmin; Relkin Norman; Ghiso Jorge; Smith Jonathan D; Gandy Sam
Human cerebrospinal fluid apolipoprotein E isoforms are apparently inefficient at complexing with synthetic Alzheimer's amyloid-[beta] peptide (A[beta] 1-40 ) in vitro.
Molecular medicine (Cambridge, Mass.) 2002;8(7):376-81.
2002: Revesz Tamas; Holton Janice L; Lashley Tammaryn; Plant Gordon; Rostagno Agueda; Ghiso Jorge; Frangione Blas
Sporadic and familial cerebral amyloid angiopathies.
Brain pathology (Zurich, Switzerland) 2002;12(3):343-57.
2002: Mackic Jasmina B; Bading James; Ghiso Jorge; Walker Larry; Wisniewski Thomas; Frangione Blas; Zlokovic Berislav V
Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.
Vascular pharmacology 2002;38(6):303-13.
2002: Bading James R; Yamada Shinya; Mackic Jasmina B; Kirkman Linda; Miller Carol; Calero Miguel; Ghiso Jorge; Frangione Blas; Zlokovic Berislav V
Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy.
Journal of drug targeting 2002;10(4):359-68.
2002: Monro O R; Mackic J B; Yamada S; Segal M B; Ghiso J; Maurer C; Calero M; Frangione B; Zlokovic B V
Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood.
Neurobiology of aging 2002;23(3):405-12.
2002: Holton Janice L; Lashley Tammaryn; Ghiso Jorge; Braendgaard Hans; Vidal Ruben; Guerin Christopher J; Gibb Graham; Hanger Diane P; Rostagno Agueda; Anderton Brian H; Strand Catherine; Ayling Hilary; Plant Gordon; Frangione Blas; Bojsen-Møller Marie; Revesz Tamas
Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
Journal of neuropathology and experimental neurology 2002;61(3):254-67.
2001: Ghiso J; Révész T; Holton J; Rostagno A; Lashley T; Houlden H; Gibb G; Anderton B; Bek T; Bojsen-Møller M; Wood N; Vidal R; Braendgaard H; Plant G; Frangione B
Chromosome 13 dementia syndromes as models of neurodegeneration.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8(4):277-84.
2001: Poeggeler B; Miravalle L; Zagorski M G; Wisniewski T; Chyan Y J; Zhang Y; Shao H; Bryant-Thomas T; Vidal R; Frangione B; Ghiso J; Pappolla M A
Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.
Biochemistry 2001;40(49):14995-5001.
2001: Ghiso J A; Holton J; Miravalle L; Calero M; Lashley T; Vidal R; Houlden H; Wood N; Neubert T A; Rostagno A; Plant G; Revesz T; Frangione B
Systemic amyloid deposits in familial British dementia.
The Journal of biological chemistry 2001;276(47):43909-14.
2001: Frangione B; Révész T; Vidal R; Holton J; Lashley T; Houlden H; Wood N; Rostagno A; Plant G; Ghiso J
Familial cerebral amyloid angiopathy related to stroke and dementia.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8 Suppl 1():36-42.
2001: Pappolla M A; Omar R A; Chyan Y J; Ghiso J; Hsiao K; Bozner P; Perry G; Smith M A; Cruz-Sanchez F
Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".
Journal of neurochemistry 2001;78(1):121-8.
2001: Teng M H; Yin J Y; Vidal R; Ghiso J; Kumar A; Rabenou R; Shah A; Jacobson D R; Tagoe C; Gallo G; Buxbaum J
Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis.
Laboratory investigation; a journal of technical methods and pathology 2001;81(3):385-96.
2001: Vidal R; Calero M; Révész T; Plant G; Ghiso J; Frangione B
Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family.
Gene 2001;266(1-2):95-102.
2001: Holton J L; Ghiso J; Lashley T; Rostagno A; Guerin C J; Gibb G; Houlden H; Ayling H; Martinian L; Anderton B H; Wood N W; Vidal R; Plant G; Frangione B; Revesz T
Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia.
The American journal of pathology 2001;158(2):515-26.
2000: Shibata M; Yamada S; Kumar S R; Calero M; Bading J; Frangione B; Holtzman D M; Miller C A; Strickland D K; Ghiso J; Zlokovic B V
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
The Journal of clinical investigation 2000;106(12):1489-99.
2000: Vidal R; Ghiso J; Frangione B
New familial forms of cerebral amyloid and dementia.
Molecular psychiatry 2000;5(6):575-6.
2000: Chen F; Yang D S; Petanceska S; Yang A; Tandon A; Yu G; Rozmahel R; Ghiso J; Nishimura M; Zhang D M; Kawarai T; Levesque G; Mills J; Levesque L; Song Y Q; Rogaeva E; Westaway D; Mount H; Gandy S; St George-Hyslop P; Fraser P E
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
The Journal of biological chemistry 2000;275(47):36794-802.
2000: Miravalle L; Tokuda T; Chiarle R; Giaccone G; Bugiani O; Tagliavini F; Frangione B; Ghiso J
Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.
The Journal of biological chemistry 2000;275(35):27110-6.
2000: Calero M; Rostagno A; Matsubara E; Zlokovic B; Frangione B; Ghiso J
Apolipoprotein J (clusterin) and Alzheimer's disease.
Microscopy research and technique 2000;50(4):305-15.
2000: Vidal R; Calero M; Piccardo P; Farlow M R; Unverzagt F W; Méndez E; Jiménez-Huete A; Beavis R; Gallo G; Gomez-Tortosa E; Ghiso J; Hyman B T; Frangione B; Ghetti B
Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele.
Acta neuropathologica 2000;100(1):1-12.
2000: Zlokovic B V; Yamada S; Holtzman D; Ghiso J; Frangione B
Clearance of amyloid beta-peptide from brain: transport or metabolism?
Nature medicine 2000;6(7):718-9.
2000: Tokuda T; Calero M; Matsubara E; Vidal R; Kumar A; Permanne B; Zlokovic B; Smith J D; Ladu M J; Rostagno A; Frangione B; Ghiso J
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.
The Biochemical journal 2000;348 Pt 2():359-65.
2000: Mead S; James-Galton M; Revesz T; Doshi R B; Harwood G; Pan E L; Ghiso J; Frangione B; Plant G
Familial British dementia with amyloid angiopathy: early clinical, neuropsychological and imaging findings.
Brain : a journal of neurology 2000;123 ( Pt 5)():975-91.
2000: Ghiso J; Vidal R; Rostagno A; Mead S; Révész T; Plant G; Frangione B
A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia.
Annals of the New York Academy of Sciences 2000;903():129-37.
2000: Vidal R; Revesz T; Rostagno A; Kim E; Holton J L; Bek T; Bojsen-Møller M; Braendgaard H; Plant G; Ghiso J; Frangione B
A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4920-5.
2000: Askanas V; Engel W K; Alvarez R B; Frangione B; Ghiso J; Vidal R
Inclusion body myositis, muscle blood vessel and cardiac amyloidosis, and transthyretin Val122Ile allele.
Annals of neurology 2000;47(4):544-9.
2000: Strazielle N; Ghersi-Egea J F; Ghiso J; Dehouck M P; Frangione B; Patlak C; Fenstermacher J; Gorevic P
In vitro evidence that beta-amyloid peptide 1-40 diffuses across the blood-brain barrier and affects its permeability.
Journal of neuropathology and experimental neurology 2000;59(1):29-38.
2000: Ghiso J; Vidal R; Rostagno A; Miravalle L; Holton J L; Mead S; Révész T; Plant G; Frangione B
Amyloidogenesis in familial British dementia is associated with a genetic defect on chromosome 13.
Annals of the New York Academy of Sciences 2000;920():84-92.
2000: Frangione B; Vidal R; Rostagno A; Ghiso J
Familial cerebral amyloid angiopathies and dementia.
Alzheimer disease and associated disorders 2000;14 Suppl 1():S25-30.
2000: Pappolla M A; Chyan Y J; Poeggeler B; Frangione B; Wilson G; Ghiso J; Reiter R J
An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(2):203-31.
1999: Rostagno A; Vidal R; Kaplan B; Chuba J; Kumar A; Elliott J I; Frangione B; Gallo G; Ghiso J
pH-dependent fibrillogenesis of a VkappaIII Bence Jones protein.
British journal of haematology 1999;107(4):835-43.
1999: Vidal R; Goñi F; Stevens F; Aucouturier P; Kumar A; Frangione B; Ghiso J; Gallo G
Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition.
The American journal of pathology 1999;155(6):2009-17.
1999: Calero M; Tokuda T; Rostagno A; Kumar A; Zlokovic B; Frangione B; Ghiso J
Functional and structural properties of lipid-associated apolipoprotein J (clusterin).
The Biochemical journal 1999;344 Pt 2():375-83.
1999: Pappolla M A; Chyan Y J; Poeggeler B; Bozner P; Ghiso J; LeDoux S P; Wilson G L
Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin.
Journal of pineal research 1999;27(4):226-9.
1999: Kaplan B; Vidal R; Kumar A; Ghiso J; Gallo G
Immunochemical microanalysis of amyloid proteins in fine-needle aspirates of abdominal fat.
American journal of clinical pathology 1999;112(3):403-7.
1999: Chyan Y J; Poeggeler B; Omar R A; Chain D G; Frangione B; Ghiso J; Pappolla M A
Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid.
The Journal of biological chemistry 1999;274(31):21937-42.
1999: Vidal R; Frangione B; Rostagno A; Mead S; Révész T; Plant G; Ghiso J
A stop-codon mutation in the BRI gene associated with familial British dementia.
Nature 1999;399(6738):776-81.
1999: Matsubara E; Ghiso J; Frangione B; Amari M; Tomidokoro Y; Ikeda Y; Harigaya Y; Okamoto K; Shoji M
Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome.
Annals of neurology 1999;45(4):537-41.
1999: Figueiredo-Pereira M E; Efthimiopoulos S; Tezapsidis N; Buku A; Ghiso J; Mehta P; Robakis N K
Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively.
Journal of neurochemistry 1999;72(4):1417-22.
1999: Raper J; Fung R; Ghiso J; Nussenzweig V; Tomlinson S
Characterization of a novel trypanosome lytic factor from human serum.
Infection and immunity 1999;67(4):1910-6.
1998: Mackic J B; Stins M; McComb J G; Calero M; Ghiso J; Kim K S; Yan S D; Stern D; Schmidt A M; Frangione B; Zlokovic B V
Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.
The Journal of clinical investigation 1998;102(4):734-43.
1998: Pizzolato M; Bragantini G; Bresciani P; Pavlovsky S; Chuba J; Vidal R; Rostagno A; Ghiso J
IgG1-kappa biclonal gammopathy associated with multiple myeloma suggests a regulatory mechanism.
British journal of haematology 1998;102(2):503-8.
1998: Pappolla M; Bozner P; Soto C; Shao H; Robakis N K; Zagorski M; Frangione B; Ghiso J
Inhibition of Alzheimer beta-fibrillogenesis by melatonin.
The Journal of biological chemistry 1998;273(13):7185-8.
1998: Mackic J B; Weiss M H; Miao W; Kirkman E; Ghiso J; Calero M; Bading J; Frangione B; Zlokovic B V
Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy.
Journal of neurochemistry 1998;70(1):210-5.
1997: Kaplan B; Vidal R; Kumar A; Ghiso J; Frangione B; Gallo G
Amino-terminal identity of co-existent amyloid and non-amyloid immunoglobulin kappa light chain deposits. A human disease to study alterations of protein conformation.
Clinical and experimental immunology 1997;110(3):472-8.
1997: Martel C L; Mackic J B; Matsubara E; Governale S; Miguel C; Miao W; McComb J G; Frangione B; Ghiso J; Zlokovic B V
Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta.
Journal of neurochemistry 1997;69(5):1995-2004.
1997: Ghiso J; Calero M; Matsubara E; Governale S; Chuba J; Beavis R; Wisniewski T; Frangione B
Alzheimer's soluble amyloid beta is a normal component of human urine.
FEBS letters 1997;408(1):105-8.
1997: Wisniewski T; Ghiso J; Frangione B
Biology of A beta amyloid in Alzheimer's disease.
Neurobiology of disease 1997;4(5):313-28.
1996: Rostagno A; Vidal R; Kumar A; Chuba J; Niederman G; Gold L; Frangione B; Ghiso J; Gallo G
Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1996;28(5):676-84.
1996: González J; Ramalho-Pinto F J; Frevert U; Ghiso J; Tomlinson S; Scharfstein J; Corey E J; Nussenzweig V
Proteasome activity is required for the stage-specific transformation of a protozoan parasite.
The Journal of experimental medicine 1996;184(5):1909-18.
1996: Vidal R; Ghiso J; Wisniewski T; Frangione B
Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant.
FEBS letters 1996;393(1):19-23.
1996: Ghersi-Egea J F; Gorevic P D; Ghiso J; Frangione B; Patlak C S; Fenstermacher J D
Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries.
Journal of neurochemistry 1996;67(2):880-3.
1996: Koudinov A R; Koudinova N V; Kumar A; Beavis R C; Ghiso J
Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins.
Biochemical and biophysical research communications 1996;223(3):592-7.
1996: Matsubara E; Soto C; Governale S; Frangione B; Ghiso J
Apolipoprotein J and Alzheimer's amyloid beta solubility.
The Biochemical journal 1996;316 ( Pt 2)():671-9.
1996: Gallo G; Goñi F; Boctor F; Vidal R; Kumar A; Stevens F J; Frangione B; Ghiso J
Light chain cardiomyopathy. Structural analysis of the light chain tissue deposits.
The American journal of pathology 1996;148(5):1397-406.
1996: Zlokovic B V; Martel C L; Matsubara E; McComb J G; Zheng G; McCluskey R T; Frangione B; Ghiso J
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4229-34.
1996: Martel C L; Mackic J B; McComb J G; Ghiso J; Zlokovic B V
Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs.
Neuroscience letters 1996;206(2-3):157-60.
1996: Baumann M H; Wisniewski T; Levy E; Plant G T; Ghiso J
C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type.
Biochemical and biophysical research communications 1996;219(1):238-42.
1996: Giaccone G; Pedrotti B; Migheli A; Verga L; Perez J; Racagni G; Smith M A; Perry G; De Gioia L; Selvaggini C; Salmona M; Ghiso J; Frangione B; Islam K; Bugiani O; Tagliavini F
beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.
The American journal of pathology 1996;148(1):79-87.
1996: Frangione B; Castaño E M; Wisniewski T; Ghiso J; Prelli F; Vidal R
Apolipoprotein E and amyloidogenesis.
Ciba Foundation symposium 1996;199():132-41; discussion 141-5.
1995: Wisniewski T; Palha J A; Ghiso J; Frangione B
S182 protein in Alzheimer's disease neuritic plaques.
Lancet 1995;346(8986):1366.
1995: Smith M A; Siedlak S L; Richey P L; Mulvihill P; Ghiso J; Frangione B; Tagliavini F; Giaccone G; Bugiani O; Praprotnik D
Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease.
Nature medicine 1995;1(4):365-9.
1995: Ghiso J; Plant G T; Révész T; Wisniewski T; Frangione B
Familial cerebral amyloid angiopathy (British type) with nonneuritic amyloid plaque formation may be due to a novel amyloid protein.
Journal of the neurological sciences 1995;129(1):74-5.
1995: Matsubara E; Frangione B; Ghiso J
Characterization of apolipoprotein J-Alzheimer's A beta interaction.
The Journal of biological chemistry 1995;270(13):7563-7.
1995: Tomlinson S; Jansen A M; Koudinov A; Ghiso J A; Choi-Miura N H; Rifkin M R; Ohtaki S; Nussenzweig V
High-density-lipoprotein-independent killing of Trypanosoma brucei by human serum.
Molecular and biochemical parasitology 1995;70(1-2):131-8.
1994: Zlokovic B V; Martel C L; Mackic J B; Matsubara E; Wisniewski T; McComb J G; Frangione B; Ghiso J
Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta.
Biochemical and biophysical research communications 1994;205(2):1431-7.
1994: Koudinov A; Matsubara E; Frangione B; Ghiso J
The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma.
Biochemical and biophysical research communications 1994;205(2):1164-71.
1994: Kivelä T; Tarkkanen A; Frangione B; Ghiso J; Haltia M
Ocular amyloid deposition in familial amyloidosis, Finnish: an analysis of native and variant gelsolin in Meretoja's syndrome.
Investigative ophthalmology & visual science 1994;35(10):3759-69.
1994: Gallo G; Wisniewski T; Choi-Miura N H; Ghiso J; Frangione B
Potential role of apolipoprotein-E in fibrillogenesis.
The American journal of pathology 1994;145(3):526-30.
1994: Ghiso J; Gardella J E; Liem L; Gorevic P D; Frangione B
Characterization of a novel processing pathway for Alzheimer's amyloid beta precursor protein.
Neuroscience letters 1994;171(1-2):213-6.
1994: Wisniewski T; Ghiso J; Frangione B
Alzheimer's disease and soluble A beta.
Neurobiology of aging 1994;15(2):143-52.
1994: Ghiso J; Wisniewski T; Frangione B
Unifying features of systemic and cerebral amyloidosis.
Molecular neurobiology 1994;8(1):49-64.
1994: Frangione B; Wisniewski T; Ghiso J
Chaperoning Alzheimer's amyloids.
Neurobiology of aging 1994;15 Suppl 2():S97-9.
1993: Zlokovic B V; Ghiso J; Mackic J B; McComb J G; Weiss M H; Frangione B
Blood-brain barrier transport of circulating Alzheimer's amyloid beta.
Biochemical and biophysical research communications 1993;197(3):1034-40.
1993: Kivelä T; Tarkkanen A; McLean I; Ghiso J; Frangione B; Haltia M
Immunohistochemical analysis of lattice corneal dystrophies types I and II.
The British journal of ophthalmology 1993;77(12):799-804.
1993: Wisniewski T; Castano E; Ghiso J; Frangione B
Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.
Annals of neurology 1993;34(4):631-3.
1993: Gardella J E; Gorgone G A; Candela L; Ghiso J; Castaño E M; Frangione B; Gorevic P D
High-level expression and in vitro mutagenesis of a fibrillogenic 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein.
The Biochemical journal 1993;294 ( Pt 3)():667-74.
1993: Ghiso J; Matsubara E; Koudinov A; Choi-Miura N H; Tomita M; Wisniewski T; Frangione B
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
The Biochemical journal 1993;293 ( Pt 1)():27-30.
1993: Goldfarb L G; Brown P; Haltia M; Ghiso J; Frangione B; Gajdusek D C
Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4451-4.
1993: Wisniewski T; Golabek A; Matsubara E; Ghiso J; Frangione B
Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid.
Biochemical and biophysical research communications 1993;192(2):359-65.
1993: Ramabhadran T V; Gandy S E; Ghiso J; Czernik A J; Ferris D; Bhasin R; Goldgaber D; Frangione B; Greengard P
Proteolytic processing of human amyloid beta protein precursor in insect cells. Major carboxyl-terminal fragment is identical to its human counterpart.
The Journal of biological chemistry 1993;268(3):2009-12.
1992: Ghiso J; Rostagno A; Gardella J E; Liem L; Gorevic P D; Frangione B
A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.
The Biochemical journal 1992;288 ( Pt 3)():1053-9.
1992: Shoji M; Golde T E; Ghiso J; Cheung T T; Estus S; Shaffer L M; Cai X D; McKay D M; Tintner R; Frangione B
Production of the Alzheimer amyloid beta protein by normal proteolytic processing.
Science (New York, N.Y.) 1992;258(5079):126-9.
1992: Vidal R G; Ghiso J; Gallo G; Cohen M; Gambetti P L; Frangione B
Amyloidoma of the CNS. II. Immunohistochemical and biochemical study.
Neurology 1992;42(10):2024-8.
1992: Gardella J E; Gorgone G A; Munoz P C; Ghiso J; Frangione B; Gorevic P D
Beta protein precursor expression in human platelets and a megakaryocyte cell line. Possible implications for the origin of cerebral amyloidosis in Alzheimer's disease.
Laboratory investigation; a journal of technical methods and pathology 1992;67(3):303-13.
1992: Ghiso J; Wisniewski T; Vidal R; Rostagno A; Frangione B
Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease.
The Biochemical journal 1992;282 ( Pt 2)():517-22.
1992: Coria F; Moreno A; Torres A; Ahmad I; Ghiso J
Distribution of Alzheimer's disease amyloid protein precursor in normal human and rat nervous system.
Neuropathology and applied neurobiology 1992;18(1):27-35.
1991: Gorevic P D; Munoz P C; Gorgone G; Purcell J J; Rodrigues M; Ghiso J; Levy E; Haltia M; Frangione B
Amyloidosis due to a mutation of the gelsolin gene in an American family with lattice corneal dystrophy type II.
The New England journal of medicine 1991;325(25):1780-5.
1991: Wisniewski T; Ghiso J; Frangione B
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;180(3):1528.
1991: Kuruvilla A P; Hochwald G M; Ghiso J; Castaño E M; Pizzolato M; Frangione B
Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid.
Brain research 1991;565(2):337-40.
1991: Wisniewski T; Ghiso J; Frangione B
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;179(3):1247-54.
1991: Tagliavini F; Giaccone G; Verga L; Ghiso J; Frangione B; Bugiani O
Alzheimer patients: preamyloid deposits are immunoreactive with antibodies to extracellular domains of the amyloid precursor protein.
Neuroscience letters 1991;128(1):117-20.
1991: Haltia M; Ghiso J; Wisniewski T; Kiuru S; Miller D; Frangione B
Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies.
Neurobiology of aging 1991;12(4):313-6.
1991: Wisniewski T; Haltia M; Ghiso J; Frangione B
Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type.
The American journal of pathology 1991;138(5):1077-83.
1991: Tagliavini F; Prelli F; Ghiso J; Bugiani O; Serban D; Prusiner S B; Farlow M R; Ghetti B; Frangione B
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
The EMBO journal 1991;10(3):513-9.
1991: Leoni J; Ghiso J; Goñi F; Frangione B
The primary structure of the Fab fragment of protein KAU, a monoclonal immunoglobulin M cold agglutinin.
The Journal of biological chemistry 1991;266(5):2836-42.
1990: Ghiso J; Haltia M; Prelli F; Novello J; Frangione B
Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.
The Biochemical journal 1990;272(3):827-30.
1990: Levy E; Haltia M; Fernandez-Madrid I; Koivunen O; Ghiso J; Prelli F; Frangione B
Mutation in gelsolin gene in Finnish hereditary amyloidosis.
The Journal of experimental medicine 1990;172(6):1865-7.
1990: Gardella J E; Ghiso J; Gorgone G A; Marratta D; Kaplan A P; Frangione B; Gorevic P D
Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA.
Biochemical and biophysical research communications 1990;173(3):1292-8.
1990: Marangoni S; Ghiso J; Sampaio S V; Arantes E C; Giglio J R; Oliveira B; Frangione B
The complete amino acid sequence of toxin TsTX-VI isolated from the venom of the scorpion Tityus serrulatus.
Journal of protein chemistry 1990;9(5):595-601.
1990: Haltia M; Ghiso J; Prelli F; Gallo G; Kiuru S; Somer H; Palo J; Frangione B
Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin.
The American journal of pathology 1990;136(6):1223-8.
1990: Tagliavini F; Ghiso J; Timmers W F; Giaccone G; Bugiani O; Frangione B
Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls.
Laboratory investigation; a journal of technical methods and pathology 1990;62(6):761-7.
1990: Haltia M; Prelli F; Ghiso J; Kiuru S; Somer H; Palo J; Frangione B
Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein.
Biochemical and biophysical research communications 1990;167(3):927-32.
1990: Ghiso J; Saball E; Leoni J; Rostagno A; Frangione B
Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1288-91.
1989: Ghiso J; Tagliavini F; Timmers W F; Frangione B
Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization.
Biochemical and biophysical research communications 1989;163(1):430-7.
1989: Levy E; Lopez-Otin C; Ghiso J; Geltner D; Frangione B
Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases.
The Journal of experimental medicine 1989;169(5):1771-8.
1989: Gowda D C; Margolis R K; Frangione B; Ghiso J; Larrondo-Lillo M; Margolis R U
Relation of the amyloid beta protein precursor to heparan sulfate proteoglycans.
Science (New York, N.Y.) 1989;244(4906):826-8.
1988: Ghiso J; Cowan N; Frangione B
Isolation of a sequence encoding human cystatin C. Conservation of exon-intron structure between members of the cysteine proteinase inhibitors superfamily.
Biological chemistry Hoppe-Seyler 1988;369 Suppl():205-8.
1987: Warfel A H; Zucker-Franklin D; Frangione B; Ghiso J
Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation.
The Journal of experimental medicine 1987;166(6):1912-7.
1987: Castaño E M; Ghiso J A; Frangione B
[Amyloidosis of the central nervous system]
Medicina 1987;47(5):534-42.
1986: Castaño E M; Ghiso J; Prelli F; Gorevic P D; Migheli A; Frangione B
In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein.
Biochemical and biophysical research communications 1986;141(2):782-9.
1986: Ghiso J; Jensson O; Frangione B
Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C).
Proceedings of the National Academy of Sciences of the United States of America 1986;83(9):2974-8.
1986: Ghiso J; Pons-Estel B; Frangione B
Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases.
Biochemical and biophysical research communications 1986;136(2):548-54.
1986: Ghiso J; Solomon A; Frangione B
Association of human lambda light chain V/J/C segments: serologic analysis and primary structure of the lambda VI Bence Jones protein THO.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(2):716-9.

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