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Hossein Ghofrani

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Christopher J Rhodes; Tino Roexe; Ralph Schermuly; Henning Tiede; Hilda Tsang; John Wharton; Beata Wojciak-Stothard; Andreas M Zeiher; Reinier A Boon; Anob Chakrabarti; Robin Condliffe; Stefanie Dimmeler; Charles A Elliot; Hossein A Ghofrani; J Simon R Gibbs; Luke S Howard; Les Huson; David G Kiely; Allan Lawrie; Martin R Wilkins
Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.
Christine Veith; Florian Veit; Norbert Weissmann; Jochen Wilhelm; Bhola Kumar Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Gabriel Marta; Ralph Theo Schermuly; Sigrid Schmitt; Werner Seeger; Grazyna Kwapiszewska
Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension.
Rajkumar Savai; Axel Scheed; Werner Seeger; Axel Vater; Robert Voswinckel; Norbert Weissmann; Gamal-Andre Banat; Ewa Bieniek; Bhola K Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Sven Klussmann; Julia Kolbe; Soni Pullamsetti; Christin Ritter; Ralph Theo Schermuly
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.

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2013: Christopher J Rhodes; Tino Roexe; Ralph Schermuly; Henning Tiede; Hilda Tsang; John Wharton; Beata Wojciak-Stothard; Andreas M Zeiher; Reinier A Boon; Anob Chakrabarti; Robin Condliffe; Stefanie Dimmeler; Charles A Elliot; Hossein A Ghofrani; J Simon R Gibbs; Luke S Howard; Les Huson; David G Kiely; Allan Lawrie; Martin R Wilkins
Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2013;187(3):294-302.
2013: Christine Veith; Florian Veit; Norbert Weissmann; Jochen Wilhelm; Bhola Kumar Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Gabriel Marta; Ralph Theo Schermuly; Sigrid Schmitt; Werner Seeger; Grazyna Kwapiszewska
Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension.
Proteomics 2013;13(1):75-88.
2012: Rajkumar Savai; Axel Scheed; Werner Seeger; Axel Vater; Robert Voswinckel; Norbert Weissmann; Gamal-Andre Banat; Ewa Bieniek; Bhola K Dahal; Ludger Fink; Hossein A Ghofrani; Friedrich Grimminger; Walter Klepetko; Sven Klussmann; Julia Kolbe; Soni Pullamsetti; Christin Ritter; Ralph Theo Schermuly
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2012;186(9):897-908.
2012: Michael J Belly; Hossein A Ghofrani; Rory E Morty; Horst Olschewski; Richard Schulz; Werner Seeger; Christian Tanislav; Henning Tiede; Robert Voswinckel; Frank Reichenberger
HbA1c in pulmonary arterial hypertension: a marker of prognostic relevance?
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2012;31(10):1109-14.
2012: Stefano Ghio; Hossein A Ghofrani; Evangelos D Michelakis; Veselin Mitrovic; Ronald J Oudiz; Lothar Roessig; Diana Bonderman; Stephan B Felix; Reiner Frey; Marc J Semigran
Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design.
European journal of heart failure 2012;14(8):946-53.
2012: Ekkehard Grünig; Michael Halank; Gabriele Karger; Hans Klose; Hanno H Leuchte; Mona Lichtblau; Andreas Meyer; Christian Opitz; Frank Reichenberger; Stephan Rosenkranz; Hans-Jürgen Seyfarth; Stephan Sorichter; Rudolf Speich; Gerd Staehler; Heinrike Wilkens; Nicola Ehlken; Christine Fischer; Hossein A Ghofrani; Christian Nagel
Safety and efficacy of exercise training in various forms of pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;40(1):84-92.
2012: Soni Pullamsetti; Stephan Rosenkranz; Rajkumar Savai; Werner Seeger; Aleksandra Tretyn; Norbert Weissmann; Eva Maria Berghausen; Ralf P Brandes; Elsa Butrous; Ghazwan Butrous; Swati Dabral; Bhola Kumar Dahal; Hossein A Ghofrani; Friedrich Grimminger; Ralph Theo Schermuly
Role of Src tyrosine kinases in experimental pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(6):1354-65.
2012: Robert Voswinckel; M M Hoeper; T Kramm; Hossein A Ghofrani
[Right heart failure in chronic pulmonary hypertension and acute pulmonary embolism].
Der Internist 2012;53(5):545-56.
2012: Grazyna Kwapiszewska; Philipp Markart; Leigh Matthew Marsh; Andreas Meinhardt; Andrea Olschewski; Klaus Theo Preissner; Ralph Theo Schermuly; Werner Seeger; Martin Steinhoff; Christian Taube; Norbert Weissmann; Bhola Kumar Dahal; Hossein A Ghofrani; Baktybek Kojonazarov; Malgorzata Wygrecka
PAR-2 inhibition reverses experimental pulmonary hypertension.
Circulation research 2012;110(9):1179-91.
2012: Soni Pullamsetti; Rajkumar Savai; Werner Seeger; Norbert Weissmann; Andreas M Zeiher; Angelika Bonauer; Bhola K Dahal; Stefanie Dimmeler; Carmen Doebele; Ariane Fischer; Hossein A Ghofrani; Friedrich Grimminger; Baktybek Kojonazarov; Ralph Theo Schermuly
Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2012;185(4):409-19.
2012: Norbert Weissmann; Michael Mederos y Schnitzler; Ralf P Brandes; Alison C Brewer; Marc Freichel; Beate Fuchs; Hossein A Ghofrani; Friedrich Grimminger; Thomas Gudermann; Hermann Kalwa; Karl-Heinz Krause; Marcel Meissner; Stefan Offermanns; Oleg Pak; Ralph Theo Schermuly; Harald H H W Schmidt; Werner Seeger; Ajay M Shah; Ursula Storch; Akylbek Sydykov; Florian Veit; Alexander Dietrich
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
Nature communications 2012;3():649.
2012: Farzaneh Ketabchi; Ralph T Schermuly; Werner Seeger; S Mostafa Shid-Moosavi; Gholam A Dehghani; Bakytbek Egemnazarov; Hossein A Ghofrani; Friedrich Grimminger; Norbert Weissmann; Natascha Sommer
Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction.
Respiratory research 2012;13():7.
2011: Michael Seimetz; Akylbek Sydykov; Agnieszka Turowska; Florian Veit; Robert Voswinckel; Friederike C Weisel; Rio Dumitrascu; Bakytbek Egemnazarov; Beate Fuchs; Holger Garn; Hossein A Ghofrani; Friedrich Grimminger; Peter Jaksch; Walter Klepetko; Sawa Kostin; Grazyna Kwapiszewska; Thomas Medebach; Katrin Milger; Sandeep Nikam; Nirmal Parajuli; Alexandra Pichl; Markus Roth; Ralph T Schermuly; Werner Seeger; Norbert Weissmann
Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice.
Cell 2011;147(2):293-305.
2011: Ralph T Schermuly; Martin R Wilkins; Hossein A Ghofrani; Friedrich Grimminger
Mechanisms of disease: pulmonary arterial hypertension.
Nature reviews. Cardiology 2011;8(8):443-55.
2011: Soni Pullamsetti; Rajkumar Savai; Werner Seeger; Norbert Weissmann; Jochen Wilhelm; Dariusz Zakrzewicz; Bhola Kumar Dahal; Rio Dumitrascu; Oliver Eickelberg; Hossein A Ghofrani; Friedrich Grimminger; Andreas Guenther; Melanie Konigshoff; James Leiper; Ralph Theo Schermuly
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Science translational medicine 2011;3(87):87ra53.
2011: Robyn J Barst; Ronald J Oudiz; Anthony Beardsworth; Bruce H Brundage; Gerald Simonneau; Hossein A Ghofrani; David P Sundin; Nazzareno Galiè
Tadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hypertension.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011;30(6):632-43.
2011: R Dumitrascu; C Kulcke; M Königshoff; F Kouri; X Yang; N Morrell; Hossein A Ghofrani; Norbert Weissmann; R Reiter; Werner Seeger; Friedrich Grimminger; O Eickelberg; Ralph Theo Schermuly; S S Pullamsetti
Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;37(5):1104-18.
2011: Bhola K Dahal; Hossein A Ghofrani; Friedrich Grimminger; Rainer Heuchel; Soni Pullamsetti; Werner Seeger; Norbert Weissmann; Jochen Wilhelm; Ralph Theo Schermuly
Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.
Pulmonary circulation 2011;1(2):259-68.
2011: Melanie Thamm; Henning Tiede; Robert Voswinckel; Friedrich Grimminger; Friederike Lendeckel; Werner Seeger; Hossein A Ghofrani
Air travel can be safe and well tolerated in patients with clinically stable pulmonary hypertension.
Pulmonary circulation 2011;1(2):239-43.
2011: Marius M Hoeper; S Andreas; A Bastian; M Claussen; Hossein A Ghofrani; M Gorenflo; C Grohé; A Günther; Michael Halank; P Hammerl; M Held; S Krüger; T J Lange; F Reichenberger; A Sablotzki; G Staehler; W Stark; Hubert Wirtz; C Witt; Jürgen Behr
[Pulmonary hypertension due to chronic lung disease. Recommendations of the Cologne Consensus Conference 2010].
Pneumologie (Stuttgart, Germany) 2011;65(4):208-18.
2011: Soni Savai Pullamsetti; Rajkumar Savai; Martina Barbara Schaefer; Jochen Wilhelm; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; Ingrid Fleming; Konstantin Mayer; James Leiper; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Circulation 2011;123(11):1194-204.
2011: Djuro Kosanovic; Himal Luitel; Werner Seeger; Akylbek Sydykov; Norbert Weissmann; Ralf P Brandes; Teodora Cornitescu; Bhola K Dahal; Neil Davie; Hossein A Ghofrani; Friedrich Grimminger; Wiebke Janssen; Baktybek Kojonazarov; Ralph Theo Schermuly
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Respiratory research 2011;12():87.
2011: Bhola K Dahal; Djuro Kosanovic; Christina Kaulen; Teodora Cornitescu; Rajkumar Savai; Julia Hoffmann; Irwin Reiss; Hossein A Ghofrani; Norbert Weissmann; Wolfgang M Kuebler; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats.
Respiratory research 2011;12():60.
2011: Beate Fuchs; Markus Rupp; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Thomas Gudermann; Alexander Dietrich; Norbert Weissmann
Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.
Respiratory research 2011;12():20.
2011: S S Pullamsetti; Rajkumar Savai; W Janssen; B K Dahal; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani; Norbert Weissmann; Ralph Theo Schermuly
Inflammation, immunological reaction and role of infection in pulmonary hypertension.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2011;17(1):7-14.
2011: Helge Möllmann; H M Nef; S Voss; Christian Troidl; Matthias Willmer; S Szardien; A Rolf; M Klement; Robert Voswinckel; Sawa Kostin; Hossein A Ghofrani; C W Hamm; Albrecht Elsässer
Stem cell-mediated natural tissue engineering.
Journal of cellular and molecular medicine 2011;15(1):52-62.
2010: Friedrich Grimminger; Ralph T Schermuly; Hossein A Ghofrani
Targeting non-malignant disorders with tyrosine kinase inhibitors.
Nature reviews. Drug discovery 2010;9(12):956-70.
2010: Hossein A Ghofrani; Nicholas W Morrell; Marius M Hoeper; Horst Olschewski; Andrew J Peacock; Robyn J Barst; Shelley Shapiro; Heiko Golpon; Mark Toshner; Friedrich Grimminger; Steve Pascoe
Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy.
American journal of respiratory and critical care medicine 2010;182(9):1171-7.
2010: N Sommer; O Pak; S Schörner; T Derfuss; A Krug; E Gnaiger; Hossein A Ghofrani; Ralph Theo Schermuly; C Huckstorf; Werner Seeger; Friedrich Grimminger; Norbert Weissmann
Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(5):1056-66.
2010: Hossein A Ghofrani; O Distler; F Gerhardt; M Gorenflo; E Grünig; W E Haefeli; M Held; Marius M Hoeper; C-M Kähler; H Kaemmerer; H Klose; V Köllner; B Kopp; S Mebus; A Meyer; O Miera; D Pittrow; G Riemekasten; S Rosenkranz; D Schranz; Robert Voswinckel; Horst Olschewski
[Treatment of pulmonary arterial hypertension (PAH): recommendations of the Cologne Consensus Conference 2010].
Deutsche medizinische Wochenschrift (1946) 2010;135 Suppl 3():S87-101.
2010: Marius M Hoeper; S Andreas; A Bastian; M Claussen; Hossein A Ghofrani; M Gorenflo; C Grohé; A Günther; Michael Halank; P Hammerl; M Held; S Krüger; T J Lange; F Reichenberger; A Sablotzki; G Staehler; W Stark; Hubert Wirtz; C Witt; Jürgen Behr
[Pulmonary hypertension due to chronic lung disease. Recommendations of the Cologne Consensus Conference 2010].
Deutsche medizinische Wochenschrift (1946) 2010;135 Suppl 3():S115-24.
2010: B K Dahal; D Kosanovic; P K Pamarthi; A Sydykov; Y-J Lai; R Kast; H Schirok; J-P Stasch; Hossein A Ghofrani; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(4):808-18.
2010: Hossein A Ghofrani; Marius M Hoeper; M Halank; F J Meyer; G Staehler; Jürgen Behr; R Ewert; G Weimann; Friedrich Grimminger
Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(4):792-9.
2010: Marius M Hoeper; Hossein A Ghofrani; M Gorenflo; E Grünig; D Schranz; S Rosenkranz
[Diagnosis and treatment of pulmonary hypertension: European guidelines 2009].
Pneumologie (Stuttgart, Germany) 2010;64(7):401-14.
2010: Martin R Wilkins; Omar Ali; William Bradlow; John Wharton; Anne Taegtmeyer; Christopher J Rhodes; Hossein A Ghofrani; Luke Howard; Petros Nihoyannopoulos; Raad H Mohiaddin; J Simon R Gibbs
Simvastatin as a treatment for pulmonary hypertension trial.
American journal of respiratory and critical care medicine 2010;181(10):1106-13.
2010: Horst Olschewski; Marius M Hoeper; Jürgen Behr; Ralf Ewert; Andreas Meyer; Mathias M Borst; Jörg Winkler; Michael Pfeifer; Heinrike Wilkens; Hossein A Ghofrani; Sylvia Nikkho; Werner Seeger
Long-term therapy with inhaled iloprost in patients with pulmonary hypertension.
Respiratory medicine 2010;104(5):731-40.
2010: Bhola Kumar Dahal; Teodora Cornitescu; Aleksandra Tretyn; Soni Savai Pullamsetti; Djuro Kosanovic; Rio Dumitrascu; Hossein A Ghofrani; Norbert Weissmann; Robert Voswinckel; Gamal-Andre Banat; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2010;181(2):158-67.
2010: Sevdalina Nikolova; Andreas Guenther; Rajkumar Savai; Norbert Weissmann; Hossein A Ghofrani; Melanie Konigshoff; Oliver Eickelberg; Walter Klepetko; Robert Voswinckel; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly; Soni Pullamsetti
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.
Respiratory research 2010;11():146.
2010: Bakytbek Egemnazarov; Ralph Theo Schermuly; Bhola K Dahal; Garry T Elliott; Niel C Hoglen; Mark W Surber; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction.
Respiratory research 2010;11():81.
2010: Sergey Udalov; Rio Dumitrascu; Soni Pullamsetti; Hamza M Al-tamari; Norbert Weissmann; Hossein A Ghofrani; Andreas Guenther; Robert Voswinckel; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.
BMC pulmonary medicine 2010;10():26.
2009: Ronald J Oudiz; Nazzareno Galiè; Horst Olschewski; Fernando Torres; Adaani Frost; Hossein A Ghofrani; David B Badesch; Michael D McGoon; Vallerie V McLaughlin; Ellen B Roecker; Brooke C Harrison; Darrin Despain; Christopher Dufton; Lewis J Rubin
Long-term ambrisentan therapy for the treatment of pulmonary arterial hypertension.
Journal of the American College of Cardiology 2009;54(21):1971-81.
2009: Frank Reichenberger; L-E Wehner; Andreas Breithecker; Robert Voswinckel; O Mensch; Richard Schulz; Hossein A Ghofrani
[Pulmonary hypertension in hereditary haemorrhagic teleangiectasia].
Pneumologie (Stuttgart, Germany) 2009;63(11):669-74.
2009: Ewa Kolosionek; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Andreas Guenther; Friedrich Grimminger; Werner Seeger; Gamal-Andre Banat; Ralph Theo Schermuly; Soni Pullamsetti
Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.
Molecular biology of the cell 2009;20(22):4751-65.
2009: Farzaneh Ketabchi; Bakytbek Egemnazarov; Ralph T Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Mostafa Shid-Moosavi; Gholam A Dehghani; Norbert Weissmann; Natascha Sommer
Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction.
American journal of physiology. Lung cellular and molecular physiology 2009;297(5):L977-83.
2009: Frank Reichenberger; Robert Voswinckel; R Schulz; O Mensch; Hossein A Ghofrani; H Olschewski; Werner Seeger
Noninvasive detection of early pulmonary vascular dysfunction in scleroderma.
Respiratory medicine 2009;103(11):1713-8.
2009: Norbert Weissmann; Sascha Hackemack; Bhola Kumar Dahal; Soni Savai Pullamsetti; Rajkumar Savai; Manish Mittal; Beate Fuchs; Thomas Medebach; Rio Dumitrascu; Martin van Eickels; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.
American journal of physiology. Lung cellular and molecular physiology 2009;297(4):L658-65.
2009: Robert Voswinckel; Frank Reichenberger; H Gall; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
[Therapy of pulmonary arterial hypertension].
Der Internist 2009;50(9):1101-2, 1104-9.
2009: Markus Roth; Markus Rupp; Simone Hofmann; Manish Mittal; Beate Fuchs; Natascha Sommer; Nirmal Parajuli; Karin Quanz; Dominic Schubert; Eva Dony; Ralph Theo Schermuly; Hossein A Ghofrani; Ulrike Sausbier; Katrin Rutschmann; Sarah Wilhelm; Werner Seeger; Peter Ruth; Friedrich Grimminger; Matthias Sausbier; Norbert Weissmann
Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.
American journal of respiratory and critical care medicine 2009;180(4):353-64.
2009: Hossein A Ghofrani
[Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension].
Deutsche medizinische Wochenschrift (1946) 2009;134 Suppl 5():S177-8.
2009: Philipp Markart; Hossein A Ghofrani; Friedrich Grimminger; A Günther
[Pulmonary hypertension in COPD and interstitial lung diseases].
Deutsche medizinische Wochenschrift (1946) 2009;134 Suppl 5():S164-6.
2009: Robyn J Barst; J Simon R Gibbs; Hossein A Ghofrani; Marius M Hoeper; Vallerie V McLaughlin; Lewis J Rubin; Olivier Sitbon; Victor F Tapson; Nazzareno Galiè
Updated evidence-based treatment algorithm in pulmonary arterial hypertension.
Journal of the American College of Cardiology 2009;54(1 Suppl):S78-84.
2009: Hossein A Ghofrani; Robyn J Barst; Raymond L Benza; Hunter C Champion; Karen A Fagan; Friedrich Grimminger; Marc Humbert; Gérald Simonneau; Duncan J Stewart; Carlo Ventura; Lewis J Rubin
Future perspectives for the treatment of pulmonary arterial hypertension.
Journal of the American College of Cardiology 2009;54(1 Suppl):S108-17.
2009: Nazzareno Galiè; Bruce H Brundage; Hossein A Ghofrani; Ronald J Oudiz; Gerald Simonneau; Zeenat Safdar; Shelley Shapiro; R James White; Melanie Chan; Anthony Beardsworth; Lyn Frumkin; Robyn J Barst
Tadalafil therapy for pulmonary arterial hypertension.
Circulation 2009;119(22):2894-903.
2009: Ying Yu; Steve H Keller; Carmelle V Remillard; Olga Safrina; Ann Nicholson; Shenyuan L Zhang; Weihua Jiang; Nivruthi Vangala; Judd W Landsberg; Jian-Ying Wang; Patricia A Thistlethwaite; Richard N Channick; Ivan M Robbins; James E Loyd; Hossein A Ghofrani; Friedrich Grimminger; Ralph T Schermuly; Michael D Cahalan; Lewis J Rubin; Jason X-J Yuan
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.
Circulation 2009;119(17):2313-22.
2009: Friedrich Grimminger; G Weimann; Reiner Frey; Robert Voswinckel; M Thamm; D Bölkow; Norbert Weissmann; W Mück; S Unger; G Wensing; Ralph Theo Schermuly; Hossein A Ghofrani
First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(4):785-92.
2009: K Woyda; S Koebrich; Irwin Reiss; Silvia Rudloff; Soni Pullamsetti; A Rühlmann; Norbert Weissmann; Hossein A Ghofrani; Andreas Günther; Werner Seeger; Friedrich Grimminger; Rory Morty; Ralph Theo Schermuly
Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(4):861-70.
2009: Bakytbek Egemnazarov; Akylbek Sydykov; Ralph Theo Schermuly; Norbert Weissmann; Johannes-Peter Stasch; Akpai S Sarybaev; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology 2009;296(3):L462-9.
2009: Robert Voswinckel; Frank Reichenberger; Henning Gall; Thomas Schmehl; Tobias Gessler; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Werner Seeger; Hossein A Ghofrani; Horst Olschewski
Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2009;22(1):50-6.
2008: N Sommer; Alexander Dietrich; Ralph Theo Schermuly; Hossein A Ghofrani; Thomas Gudermann; Rainer Schulz; Werner Seeger; Friedrich Grimminger; Norbert Weissmann
Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(6):1639-51.
2008: Martina Klein; Ralph Theo Schermuly; Peter Ellinghaus; Hendrik Milting; Bernd Riedl; Sevdalina Nikolova; Soni S Pullamsetti; Norbert Weissmann; Eva Dony; Rajkumar Savai; Hossein A Ghofrani; Friedrich Grimminger; Andreas E Busch; Stefan Schäfer
Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling.
Circulation 2008;118(20):2081-90.
2008: Marius M Hoeper; Hossein A Ghofrani; Friedrich Grimminger; S Rosenkranz
[Dana Point: what is new in the treatment of pulmonary hypertension?].
Deutsche medizinische Wochenschrift (1946) 2008;133 Suppl 6():S191-5.
2008: Robert Voswinckel; Frank Reichenberger; Beate Enke; Andre Kreckel; Stefanie Krick; Henning Gall; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Horst Olschewski; Werner Seeger; Hossein A Ghofrani
Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.
Pulmonary pharmacology & therapeutics 2008;21(5):824-32.
2008: Ralph Theo Schermuly; J-P Stasch; Soni Pullamsetti; Ralf Middendorff; D Müller; Klaus-Dieter Schlüter; A Dingendorf; S Hackemack; E Kolosionek; C Kaulen; Rio Dumitrascu; Norbert Weissmann; J Mittendorf; Walter Klepetko; Werner Seeger; Hossein A Ghofrani; Friedrich Grimminger
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(4):881-91.
2008: Hossein A Ghofrani; Martin W Wilkins; Stuart Rich
Uncertainties in the diagnosis and treatment of pulmonary arterial hypertension.
Circulation 2008;118(11):1195-201.
2008: Grazyna Kwapiszewska; Malgorzata Wygrecka; Leigh M Marsh; Sigrid Schmitt; Roger Trösser; Jochen Wilhelm; Katja Helmus; Bastian Eul; Anna Zakrzewicz; Hossein A Ghofrani; Ralph Theo Schermuly; Rainer M Bohle; Friedrich Grimminger; Werner Seeger; Oliver Eickelberg; Ludger Fink; Norbert Weissmann
Fhl-1, a new key protein in pulmonary hypertension.
Circulation 2008;118(11):1183-94.
2008: Ying-Ju Lai; Soni Pullamsetti; Eva Dony; Norbert Weissmann; Ghazwan Butrous; Gamal-Andre Banat; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension.
American journal of respiratory and critical care medicine 2008;178(2):188-96.
2008: Nazzareno Galiè; Horst Olschewski; Ronald J Oudiz; Fernando Torres; Adaani Frost; Hossein A Ghofrani; David B Badesch; Michael D McGoon; Vallerie V McLaughlin; Ellen B Roecker; Michael J Gerber; Christopher Dufton; Brian L Wiens; Lewis J Rubin
Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.
Circulation 2008;117(23):3010-9.
2008: István Vadász; Ralph Theo Schermuly; Hossein A Ghofrani; Sebastian Rummel; Susan Wehner; Inge Mühldorfer; Klaus P Schäfer; Werner Seeger; Rory Morty; Friedrich Grimminger; Norbert Weissmann
The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs.
Critical care medicine 2008;36(5):1543-50.
2008: Hossein A Ghofrani
[The treatment of pulmonary arterial hypertension associated with chronic obstructive pulmonary disease makes sense - pro].
Deutsche medizinische Wochenschrift (1946) 2008;133(14):720.
2008: Eva Dony; Y-J Lai; Rio Dumitrascu; Soni Pullamsetti; Rajkumar Savai; Hossein A Ghofrani; Norbert Weissmann; Christian Schudt; D Flockerzi; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(3):599-610.
2008: Rio Dumitrascu; Silke Koebrich; Eva Dony; Norbert Weissmann; Rajkumar Savai; Soni Pullamsetti; Hossein A Ghofrani; Arun Samidurai; Heiko Traupe; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.
BMC pulmonary medicine 2008;8():25.
2008: Hans-Joachim Kabitz; Anja Schwoerer; Hinrich C Bremer; Florian Sonntag; Stephan Walterspacher; David Walker; Vanessa Schaefer; Nicola Ehlken; Gerd Staehler; Michael Halank; Hans Klose; Hossein A Ghofrani; Marius M Hoeper; Ekkehard Gruenig; Wolfram Windisch
Impairment of respiratory muscle function in pulmonary hypertension.
Clinical science (London, England : 1979) 2008;114(2):165-71.
2007: Frank Reichenberger; Markus G Kohstall; Timon Seeger; Horst Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function.
Respiratory physiology & neurobiology 2007;159(2):196-201.
2007: Frank Reichenberger; Robert Voswinckel; Beate Enke; M Rutsch; E El Fechtali; Thomas Schmehl; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Hossein A Ghofrani; Friedrich Grimminger; E Mayer; Werner Seeger
Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(5):922-7.
2007: Norbert Weissmann; Boris Gerigk; Ozlem Kocer; Matthias Nollen; Sascha Hackemack; Hossein A Ghofrani; Ralph Theo Schermuly; Ghazwan Butrous; Andreas Schulz; Markus Roth; Werner Seeger; Friedrich Grimminger
Hypoxia-induced pulmonary hypertension: different impact of iloprost, sildenafil, and nitric oxide.
Respiratory medicine 2007;101(10):2125-32.
2007: Manish Mittal; Markus Roth; Peter König; Simone Hofmann; Eva Dony; Parag Goyal; Anne-Christin Selbitz; Ralph Theo Schermuly; Hossein A Ghofrani; Grazyna Kwapiszewska; Wolfgang Kummer; Walter Klepetko; Mir Ali Reza Hoda; Ludger Fink; Jörg Hänze; Werner Seeger; Friedrich Grimminger; Harald Schmidt; Norbert Weissmann
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.
Circulation research 2007;101(3):258-67.
2007: Rajkumar Savai; Ralph Theo Schermuly; Soni Pullamsetti; Michael Schneider; Susanne Greschus; Hossein A Ghofrani; Heiko Traupe; Friedrich Grimminger; Gamal-Andre Banat
A combination hybrid-based vaccination/adoptive cellular therapy to prevent tumor growth by involvement of T cells.
Cancer research 2007;67(11):5443-53.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Grazyna Kwapiszewska; Rio Dumitrascu; Xia Tian; Norbert Weissmann; Hossein A Ghofrani; Christina Kaulen; Torsten R Dunkern; Christian Schudt; Robert Voswinckel; Jiang Zhou; Arun Samidurai; Walter Klepetko; Renate Paddenberg; Wolfgang Kummer; Werner Seeger; Friedrich Grimminger
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
Circulation 2007;115(17):2331-9.
2007: Andreas Günther; Beate Enke; Philipp Markart; P Hammerl; Harald Morr; Jürgen Behr; Gerd Stähler; Werner Seeger; Friedrich Grimminger; I Leconte; S Roux; Hossein A Ghofrani
Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(4):713-9.
2007: Ralph Theo Schermuly; Soni Pullamsetti; Susanne C Breitenbach; Norbert Weissmann; Hossein A Ghofrani; Friedrich Grimminger; Sigrid M Nilius; Karsten Schrör; Jutta M Kirchrath; Werner Seeger; Frank Rose
Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs.
Respiratory research 2007;8():4.
2007: Bernhard Rosengarten; Mirko Hecht; Dieter Auch; Hossein A Ghofrani; Ralph Theo Schermuly; Friedrich Grimminger; Manfred Kaps
Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats.
Cerebrovascular diseases (Basel, Switzerland) 2007;23(2-3):140-7.
2006: Marius M Hoeper; Stephen H Lee; Robert Voswinckel; Massimiliano Palazzini; Xavier Jais; Alessandro Marinelli; Robyn J Barst; Hossein A Ghofrani; Zhi-Cheng Jing; Christian F Opitz; Hans-Juergen Seyfarth; Michael Halank; Vallerie V McLaughlin; Ronald J Oudiz; Ralf Ewert; Heinrike Wilkens; Stefan Kluge; Hinrich C Bremer; Eva Baroke; Lewis J Rubin
Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers.
Journal of the American College of Cardiology 2006;48(12):2546-52.
2006: Norbert Weissmann; Alexander Dietrich; Beate Fuchs; Hermann Kalwa; Mahmut Ay; Rio Dumitrascu; Andrea Olschewski; Ursula Storch; Michael Mederos y Schnitzler; Hossein A Ghofrani; Ralph Theo Schermuly; Olaf Pinkenburg; Werner Seeger; Friedrich Grimminger; Thomas Gudermann
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19093-8.
2006: Hossein A Ghofrani; S Rosenkranz; Friedrich Grimminger
[Future aspects of the treatment of pulmonary arterial hypertension].
Deutsche medizinische Wochenschrift (1946) 2006;131(49 Suppl 9):S338-40.
2006: Hossein A Ghofrani; M M Hoeper
[Drug combination treatment for pulmonary arterial hypertension].
Deutsche medizinische Wochenschrift (1946) 2006;131(49 Suppl 9):S330-3.
2006: Hossein A Ghofrani; Friedrich Grimminger
[Treatment of pulmonary arterial hypertension: phosphodiesterase-5 inhibitors].
Deutsche medizinische Wochenschrift (1946) 2006;131(49 Suppl 9):S311-4.
2006: Robert Voswinckel; Beate Enke; Frank Reichenberger; Markus G Kohstall; André Kreckel; Stefanie Krick; Henning Gall; Tobias Gessler; Thomas Schmehl; Hossein A Ghofrani; Ralph Theo Schermuly; Friedrich Grimminger; Lewis J Rubin; Werner Seeger; Horst Olschewski
Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.
Journal of the American College of Cardiology 2006;48(8):1672-81.
2006: Hossein A Ghofrani; Robert Voswinckel; Frank Reichenberger; Norbert Weissmann; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies.
Cardiovascular research 2006;72(1):30-40.
2006: Frank Reichenberger; Robert Voswinckel; E Steveling; Beate Enke; André Kreckel; Horst Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Sildenafil treatment for portopulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(3):563-7.
2006: Norbert Weissmann; Natascha Sommer; Ralph Theo Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Oxygen sensors in hypoxic pulmonary vasoconstriction.
Cardiovascular research 2006;71(4):620-9.
2006: Hossein A Ghofrani; Ian H Osterloh; Friedrich Grimminger
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.
Nature reviews. Drug discovery 2006;5(8):689-702.
2006: Hossein A Ghofrani; R T Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
[Reverse remodeling -- paradigm shift in the treatment of pulmonary hypertension].
Deutsche medizinische Wochenschrift (1946) 2006;131(16):871-4.
2006: Soni Pullamsetti; Daniel Maring; Hossein A Ghofrani; Konstantin Mayer; Norbert Weissmann; Bernhard Rosengarten; Martin Lehner; Christian Schudt; Rainer Boer; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Thrombosis and haemostasis 2006;95(4):720-7.
2006: Norbert Weissmann; Stefanie Zeller; Rolf Schäfer; Carmen Turowski; Mahmut Ay; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Ludger Fink; Werner Seeger; Friedrich Grimminger
Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction.
American journal of respiratory cell and molecular biology 2006;34(4):505-13.
2006: Robert Voswinckel; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Inhaled treprostinil [corrected] for treatment of chronic pulmonary arterial hypertension.
Annals of internal medicine 2006;144(2):149-50.
2006: Rio Dumitrascu; Norbert Weissmann; Hossein A Ghofrani; Eva Dony; Knut Beuerlein; Harald Schmidt; Johannes-Peter Stasch; Mark J Gnoth; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling.
Circulation 2006;113(2):286-95.
2006: Ralph Theo Schermuly; Andreas Schulz; Hossein A Ghofrani; Christina Susanne Breitenbach; Norbert Weissmann; Michael Hildebrand; Julia Kurz; Friedrich Grimminger; Werner Seeger
Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: rapid tolerance development.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2006;19(3):353-63.
2006: Norbert Weissmann; Ralph Theo Schermuly; Hossein A Ghofrani; Jörg Hänze; Parag Goyal; Friedrich Grimminger; Werner Seeger
Hypoxic pulmonary vasoconstriction--triggered by an increase in reactive oxygen species?
Novartis Foundation symposium 2006;272():196-208; discussion 208-17.
2006: Bernhard Rosengarten; Ralph Theo Schermuly; Robert Voswinckel; Markus G Kohstall; Horst Olschewski; Norbert Weissmann; Werner Seeger; Manfred Kaps; Friedrich Grimminger; Hossein A Ghofrani
Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension.
Cerebrovascular diseases (Basel, Switzerland) 2006;21(3):194-200.
2005: Nazzareno Galiè; Hossein A Ghofrani; Adam Torbicki; Robyn J Barst; Lewis J Rubin; David B Badesch; Thomas Fleming; Tamiza Parpia; Gary Burgess; Angelo Branzi; Friedrich Grimminger; Marcin Kurzyna; Gérald Simonneau
Sildenafil citrate therapy for pulmonary arterial hypertension.
The New England journal of medicine 2005;353(20):2148-57.
2005: Ralph Theo Schermuly; Eva Dony; Hossein A Ghofrani; Soni Pullamsetti; Rajkumar Savai; Markus Roth; Akylbek Sydykov; Ying Ju Lai; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Reversal of experimental pulmonary hypertension by PDGF inhibition.
The Journal of clinical investigation 2005;115(10):2811-21.
2005: István Vadász; Rory Morty; Andrea Olschewski; Melanie Königshoff; Markus G Kohstall; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase.
American journal of respiratory cell and molecular biology 2005;33(4):343-54.
2005: Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Imatinib for the treatment of pulmonary arterial hypertension.
The New England journal of medicine 2005;353(13):1412-3.
2005: Norbert Weissmann; Daniel Manz; Daniela Buchspies; Stephan Keller; Tanja Mehling; Robert Voswinckel; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Ludger Fink; Werner Seeger; Max Gassmann; Friedrich Grimminger
Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
Thrombosis and haemostasis 2005;94(3):630-8.
2005: Georg Friese; Jürgen Lohmeyer; Werner Seeger; Friedrich Grimminger; Hossein A Ghofrani
[HIV-associated pulmonary hypertension ].
Herz 2005;30(6):481-5.
2005: Ralph Theo Schermuly; Hüseyin Yilmaz; Hossein A Ghofrani; Kathrin Woyda; Soni Pullamsetti; Andreas Schulz; Tobias Gessler; Rio Dumitrascu; Norbert Weissmann; Friedrich Grimminger; Werner Seeger
Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 2005;172(3):358-63.
2005: Soni Pullamsetti; Ladislau Kiss; Hossein A Ghofrani; Robert Voswinckel; Peter Haredza; Walter Klepetko; Clemens Aigner; Ludger Fink; Jai Prakash Muyal; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1175-7.
2005: István Vadász; Rory Morty; Markus G Kohstall; Andrea Olschewski; Friedrich Grimminger; Werner Seeger; Hossein A Ghofrani
Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome?
American journal of respiratory and critical care medicine 2005;171(5):469-79.
2005: Soni Pullamsetti; Stefanie Krick; Hüseyin Yilmaz; Hossein A Ghofrani; Christian Schudt; Norbert Weissmann; Beate Fuchs; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.
Respiratory research 2005;6():128.
2005: Norbert Weissmann; Nermin Kuzkaya; Beate Fuchs; Vedat Tiyerili; Rolf Schäfer; Hartwig Schütte; Hossein A Ghofrani; Ralph Theo Schermuly; Christian Schudt; Akylbek Sydykov; Bakytbek Egemnazarow; Werner Seeger; Friedrich Grimminger
Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy.
Respiratory research 2005;6():86.
2005: Ralph Theo Schermuly; Christiane Inholte; Hossein A Ghofrani; Henning Gall; Norbert Weissmann; Andreas Weidenbach; Werner Seeger; Friedrich Grimminger
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.
Respiratory research 2005;6():76.
2004: Hossein A Ghofrani; Robert Voswinckel; Frank Reichenberger; Horst Olschewski; Peter Haredza; Burcu Karadaş; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study.
Journal of the American College of Cardiology 2004;44(7):1488-96.
2004: Hossein A Ghofrani; Frank Reichenberger; Markus G Kohstall; Eike Mrosek; Timon Seeger; Horst Olschewski; Werner Seeger; Friedrich Grimminger
Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial.
Annals of internal medicine 2004;141(3):169-77.
2004: Hossein A Ghofrani; Joanna Pepke-Zaba; Joan A Barbera; Richard N Channick; Anne M Keogh; Miguel A Gomez-Sanchez; Meinhard Kneussl; Friedrich Grimminger
Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension.
Journal of the American College of Cardiology 2004;43(12 Suppl S):68S-72S.
2004: Parag Goyal; Norbert Weissmann; Friedrich Grimminger; Cornelia Hegel; Lucius Bader; Frank Rose; Ludger Fink; Hossein A Ghofrani; Ralph Theo Schermuly; Harald Schmidt; Werner Seeger; Jörg Hänze
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species.
Free radical biology & medicine 2004;36(10):1279-88.
2004: Horst Olschewski; Frank Rose; Ralph Theo Schermuly; Hossein A Ghofrani; Beate Enke; Andrea Olschewski; Werner Seeger
Prostacyclin and its analogues in the treatment of pulmonary hypertension.
Pharmacology & therapeutics 2004;102(2):139-53.
2004: Ralph Theo Schermuly; Klaus Peter Kreisselmeier; Hossein A Ghofrani; Arun Samidurai; Soni Pullamsetti; Norbert Weissmann; Christian Schudt; Leander Ermert; Werner Seeger; Friedrich Grimminger
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension.
Circulation research 2004;94(8):1101-8.
2004: Norbert Weissmann; Henrik Vogels; Ralph Theo Schermuly; Hossein A Ghofrani; Jörg Hänze; Ludger Fink; Frank Rose; Werner Seeger; Friedrich Grimminger
Measurement of exhaled hydrogen peroxide from rabbit lungs.
Biological chemistry 2004;385(3-4):259-64.
2004: Hossein A Ghofrani; Georg Friese; Thomas Discher; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger; Jürgen Lohmeyer
Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(2):321-6.
2004: Norbert Weissmann; Ercan Akkayagil; Karin Quanz; Ralph Theo Schermuly; Hossein A Ghofrani; Ludger Fink; Jörg Hänze; Frank Rose; Werner Seeger; Friedrich Grimminger
Basic features of hypoxic pulmonary vasoconstriction in mice.
Respiratory physiology & neurobiology 2004;139(2):191-202.
2004: Ralph Theo Schermuly; Klaus P Kreisselmeier; Hossein A Ghofrani; Hüseyin Yilmaz; Ghazwan Butrous; Leander Ermert; Monika Ermert; Norbert Weissmann; Frank Rose; Andreas Guenther; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats.
American journal of respiratory and critical care medicine 2004;169(1):39-45.
2003: Frank Rose; Katja Hattar; Sybille Gakisch; Friedrich Grimminger; Horst Olschewski; Werner Seeger; Annette Tschuschner; Ralph Theo Schermuly; Norbert Weissmann; Jörg Hanze; Ulf Sibelius; Hossein A Ghofrani
Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost.
Thrombosis and haemostasis 2003;90(6):1141-9.
2003: Norbert Weissmann; Nadine Ebert; Marit Ahrens; Hossein A Ghofrani; Ralph Theo Schermuly; Jörg Hänze; Ludger Fink; Frank Rose; Jörg Conzen; Werner Seeger; Friedrich Grimminger
Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2003;29(6):721-32.
2003: Horst Olschewski; Beate Rohde; Jürgen Behr; Ralph Ewert; Tobias Gessler; Hossein A Ghofrani; Thomas Schmehl
Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension.
Chest 2003;124(4):1294-304.
2003: Ralph Theo Schermuly; H Leuchte; Hossein A Ghofrani; Norbert Weissmann; Frank Rose; Markus G Kohstall; Horst Olschewski; Christian Schudt; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Zardaverine and aerosolised iloprost in a model of acute respiratory failure.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;22(2):342-7.
2003: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; André Kreckel; Norbert Weissmann; Stefanie Ghofrani; Beate Enke; Werner Seeger; Friedrich Grimminger
Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension.
Journal of the American College of Cardiology 2003;42(1):158-64.
2003: Hossein A Ghofrani; Ralph Theo Schermuly; Frank Rose; Ralph Wiedemann; Markus G Kohstall; André Kreckel; Horst Olschewski; Norbert Weissmann; Beate Enke; Stefanie Ghofrani; Werner Seeger; Friedrich Grimminger
Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension.
American journal of respiratory and critical care medicine 2003;167(8):1139-41.
2002: Hossein A Ghofrani; Horst Olschewski; Werner Seeger; Friedrich Grimminger
[Sildenafil for treatment of severe pulmonary hypertension and commencing right-heart failure].
Pneumologie (Stuttgart, Germany) 2002;56(11):665-72.
2002: Hossein A Ghofrani; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Ralph Wiedemann; Norbert Weissmann; Christian Schudt; Hermann Tenor; Werner Seeger; Friedrich Grimminger
Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension.
Critical care medicine 2002;30(11):2489-92.
2002: Ralph Theo Schermuly; Andreas Schulz; Hossein A Ghofrani; Arne Meidow; Frank Rose; Axel Roehl; Norbert Weissmann; Michael Hildebrand; Julia Kurz; Friedrich Grimminger; Dieter Walmrath; Werner Seeger
Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs.
The Journal of pharmacology and experimental therapeutics 2002;303(2):741-5.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Ralph Theo Schermuly; Horst Olschewski; Norbert Weissmann; Andreas Gunther; Dieter Walmrath; Werner Seeger; Friedrich Grimminger
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial.
Lancet 2002;360(9337):895-900.
2002: Horst Olschewski; Gérald Simonneau; Nazzareno Galiè; Tim Higenbottam; Robert Naeije; Lewis J Rubin; Sylvia Nikkho; Rudolf Speich; Marius M Hoeper; Jürgen Behr; Jörg Winkler; Olivier Sitbon; Wladimir Popov; Hossein A Ghofrani; Alessandra Manes; David G Kiely; Ralph Ewert; Andreas Meyer; Paul A Corris; Marion Delcroix; Miguel Gomez-Sanchez; Harald Siedentop; Werner Seeger
Inhaled iloprost for severe pulmonary hypertension.
The New England journal of medicine 2002;347(5):322-9.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Horst Olschewski; Ralph Theo Schermuly; Norbert Weissmann; Werner Seeger; Friedrich Grimminger
Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension.
Annals of internal medicine 2002;136(7):515-22.
2002: Hossein A Ghofrani; Ralph Wiedemann; Frank Rose; Norbert Weissmann; Ralph Theo Schermuly; Karin Quanz; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Lung cGMP release subsequent to NO inhalation in pulmonary hypertension: responders versus nonresponders.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):664-71.
2002: Richard Schulz; G Baseler; Hossein A Ghofrani; Friedrich Grimminger; Horst Olschewski; Werner Seeger
Nocturnal periodic breathing in primary pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(4):658-63.
2002: Frank Rose; Gabriele Dahlem; Bernd Guthmann; Friedrich Grimminger; Ulrich A Maus; Jörg Hänze; Nils Duemmer; Ulrich Grandel; Werner Seeger; Hossein A Ghofrani
Mediator generation and signaling events in alveolar epithelial cells attacked by S. aureus alpha-toxin.
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L207-14.
2001: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; H Leuchte; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2001;281(6):L1361-8.
2001: Ralph Theo Schermuly; E Krupnik; Hermann Tenor; Christian Schudt; Norbert Weissmann; Frank Rose; Friedrich Grimminger; Werner Seeger; Dieter Walmrath; Hossein A Ghofrani
Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity.
American journal of respiratory and critical care medicine 2001;164(9):1694-700.
2001: Ralph Wiedemann; Hossein A Ghofrani; Norbert Weissmann; Ralph Theo Schermuly; Karin Quanz; Friedrich Grimminger; Werner Seeger; Horst Olschewski
Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation.
Journal of the American College of Cardiology 2001;38(4):1130-6.
2001: Ralph Theo Schermuly; Norbert Weissmann; Beate Enke; Hossein A Ghofrani; W G Forssmann; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication.
American journal of respiratory cell and molecular biology 2001;25(2):219-25.
2001: Hossein A Ghofrani; Markus G Kohstall; Norbert Weissmann; Thomas Schmehl; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Alveolar epithelial barrier functions in ventilated perfused rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(5):L896-904.
2001: Ralph Theo Schermuly; Andreas Günther; Monika Ermert; Leander Ermert; Hossein A Ghofrani; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Conebulization of surfactant and urokinase restores gas exchange in perfused lungs with alveolar fibrin formation.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L792-800.
2001: Norbert Weissmann; S Winterhalder; Matthias Nollen; Robert Voswinckel; Karin Quanz; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L638-45.
2001: Tobias Gessler; Thomas Schmehl; M M Hoeper; Frank Rose; Hossein A Ghofrani; Horst Olschewski; Friedrich Grimminger; Werner Seeger
Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(1):14-9.
2000: Norbert Weissmann; A Tadic; Jörg Hänze; Frank Rose; S Winterhalder; Matthias Nollen; Ralph Theo Schermuly; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger
Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)?
American journal of physiology. Lung cellular and molecular physiology 2000;279(4):L683-90.
2000: Norbert Weissmann; Robert Voswinckel; A Tadic; T Hardebusch; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Nitric oxide (NO)-dependent but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs.
American journal of respiratory cell and molecular biology 2000;23(2):222-7.
2000: Horst Olschewski; Hossein A Ghofrani; Thomas Schmehl; J Winkler; Heinrike Wilkens; M M Höper; Jürgen Behr; F X Kleber; Werner Seeger
Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group.
Annals of internal medicine 2000;132(6):435-43.
2000: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Ralph Theo Schermuly; Bettina Temmesfeld-Wollbrück; Friedrich Grimminger; W Seeger
[Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to pulmonary fibrosis].
Pneumologie (Stuttgart, Germany) 2000;54(3):133-42.
2000: Ralph Theo Schermuly; Axel Roehl; Norbert Weissmann; Hossein A Ghofrani; Christian Schudt; Hermann Tenor; Friedrich Grimminger; Werner Seeger; Dieter Walmrath
Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange.
The Journal of pharmacology and experimental therapeutics 2000;292(2):512-20.
2000: Marius M Hoeper; Horst Olschewski; Hossein A Ghofrani; Heinrike Wilkens; J Winkler; Mathias M Borst; Jost Niedermeyer; Helmut Fabel; W Seeger
A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group.
Journal of the American College of Cardiology 2000;35(1):176-82.
2000: Ralph Theo Schermuly; Andreas Günther; Norbert Weissmann; Hossein A Ghofrani; Werner Seeger; Friedrich Grimminger; Dieter Walmrath
Differential impact of ultrasonically nebulized versus tracheal-instilled surfactant on ventilation-perfusion (VA/Q) mismatch in a model of acute lung injury.
American journal of respiratory and critical care medicine 2000;161(1):152-9.
1999: Ralph Theo Schermuly; Hossein A Ghofrani; Beate Enke; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Christian Schudt; Dieter Walmrath
Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1500-6.
1999: Frank Rose; K Zwick; Hossein A Ghofrani; Ulf Sibelius; Werner Seeger; Dieter Walmrath; Friedrich Grimminger
Prostacyclin enhances stretch-induced surfactant secretion in alveolar epithelial type II cells.
American journal of respiratory and critical care medicine 1999;160(3):846-51.
1999: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Ralph Theo Schermuly; B Temmesfeld-Wollbruck; Friedrich Grimminger; Werner Seeger
Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.
American journal of respiratory and critical care medicine 1999;160(2):600-7.
1999: Norbert Weissmann; Robert Voswinckel; T Hardebusch; Simone Rosseau; Hossein A Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger
Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction.
The American journal of physiology 1999;276(1 Pt 1):L90-5.
1998: Horst Olschewski; Hossein A Ghofrani; Dieter Walmrath; Bettina Temmesfeld-Wollbrück; Friedrich Grimminger; Werner Seeger
Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost.
Intensive care medicine 1998;24(6):631-4.
1998: Leander Ermert; Monika Ermert; M Goppelt-Struebe; Dieter Walmrath; Friedrich Grimminger; W Steudel; Hossein A Ghofrani; C Homberger; Hans-Rainer Duncker; Werner Seeger
Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs.
American journal of respiratory cell and molecular biology 1998;18(4):479-88.
1998: Horst Olschewski; Dieter Walmrath; Ralph Theo Schermuly; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
[Prostacyclin and iloprost in aerosol form in severe pulmonary hypertension].
Pneumologie (Stuttgart, Germany) 1998;52(1):3-7.
1996: Dieter Walmrath; Hossein A Ghofrani; Friedrich Grimminger; Werner Seeger
Synergism of alveolar endotoxin "priming" and intravascular exotoxin challenge in lung injury.
American journal of respiratory and critical care medicine 1996;154(2 Pt 1):460-8.
1996: Dieter Walmrath; Andreas Günther; Hossein A Ghofrani; Ralph Theo Schermuly; T Schneider; Friedrich Grimminger; Werner Seeger
Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis.
American journal of respiratory and critical care medicine 1996;154(1):57-62.
1996: Hossein A Ghofrani; Simone Rosseau; Dieter Walmrath; W Kaddus; A Kramer; Friedrich Grimminger; Jürgen Lohmeyer; Werner Seeger
Compartmentalized lung cytokine release in response to intravascular and alveolar endotoxin challenge.
The American journal of physiology 1996;270(1 Pt 1):L62-8.
1994: Dieter Walmrath; Hossein A Ghofrani; Simone Rosseau; Hartwig Schütte; A Cramer; W Kaddus; Friedrich Grimminger; Sucharit Bhakdi; Werner Seeger
Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin.
The Journal of experimental medicine 1994;180(4):1437-43.