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Debashis Ghosh

Research Profile

Concepts & Ideas

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X Ray Crystallography

Chemicals & Drugs

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Placenta

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Publications

TOP 3
Debashis Ghosh; Jennifer Griswold; Mary Erman; Walter Pangborn
X-ray structure of human aromatase reveals an androgen-specific active site.
Debashis Ghosh
Human sulfatases: a structural perspective to catalysis.
Weonsup Lee; Kyoung-Soo Choi; Jonah Riddell; Clement Ip; Debashis Ghosh; Jong-Hoon Park; Young-Mee Park
Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2.

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All Publications

2010: Debashis Ghosh; Jennifer Griswold; Mary Erman; Walter Pangborn
X-ray structure of human aromatase reveals an androgen-specific active site.
The Journal of steroid biochemistry and molecular biology 2010;118(4-5):197-202.
2007: Debashis Ghosh
Human sulfatases: a structural perspective to catalysis.
Cellular and molecular life sciences : CMLS 2007;64(15):2013-22.
2007: Weonsup Lee; Kyoung-Soo Choi; Jonah Riddell; Clement Ip; Debashis Ghosh; Jong-Hoon Park; Young-Mee Park
Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2.
The Journal of biological chemistry 2007;282(30):22011-22.
2007: Debashis Ghosh; Jennifer B Griswold; Thomas Bevilacqua; Federico Gonzalez-Fernandez
Purification of the full-length Xenopus interphotoreceptor retinoid binding protein and growth of diffraction-quality crystals.
Molecular vision 2007;13():2275-81.
2005: Chien-Chung Chang; Francisco G Hernandez-Guzman; Wei Luo; Xinhui Wang; Soldano Ferrone; Debashis Ghosh
Structural basis of antigen mimicry in a clinically relevant melanoma antigen system.
The Journal of biological chemistry 2005;280(50):41546-52.
2005: Debashis Ghosh
Three-dimensional structures of sulfatases.
Methods in enzymology 2005;400():273-93.
2004: Debashis Ghosh
Mutations in X-linked ichthyosis disrupt the active site structure of estrone/DHEA sulfatase.
Biochimica et biophysica acta 2004;1739(1):1-4.
2004: Puloma Lala; Tadayoshi Higashiyama; Mary Erman; Jennifer Griswold; Traci Wagner; Yoshio Osawa; Debashis Ghosh
Suppression of human cytochrome P450 aromatase activity by monoclonal and recombinant antibody fragments and identification of a stable antigenic complex.
The Journal of steroid biochemistry and molecular biology 2004;88(3):235-45.
2003: Francisco G Hernandez-Guzman; Tadayoshi Higashiyama; Walter Pangborn; Yoshio Osawa; Debashis Ghosh
Structure of human estrone sulfatase suggests functional roles of membrane association.
The Journal of biological chemistry 2003;278(25):22989-97.
2001: Francisco G Hernandez-Guzman; Tadayoshi Higashiyama; Yoshio Osawa; Debashis Ghosh
Purification, characterization and crystallization of human placental estrone/dehydroepiandrosterone sulfatase, a membrane-bound enzyme of the endoplasmic reticulum.
The Journal of steroid biochemistry and molecular biology 2001;78(5):441-50.
2001: Debashis Ghosh; M Sawicki; Vladimir Pletnev; Mary Erman; S Ohno; S Nakajin; William L Duax
Porcine carbonyl reductase. structural basis for a functional monomer in short chain dehydrogenases/reductases.
The Journal of biological chemistry 2001;276(21):18457-63.
2001: Debashis Ghosh; M Sawicki; Puloma Lala; Mary Erman; Walter Pangborn; J Eyzaguirre; R Gutierrez; H Jornvall; D J Thiel
Multiple conformations of catalytic serine and histidine in acetylxylan esterase at 0.90 A.
The Journal of biological chemistry 2001;276(14):11159-66.
2001: Debashis Ghosh; Pirkko Vihko
Molecular mechanisms of estrogen recognition and 17-keto reduction by human 17beta-hydroxysteroid dehydrogenase 1.
Chemico-biological interactions 2001;130-132(1-3):637-50.
2001: Pirkko Vihko; Veli Isomaa; Debashis Ghosh
Structure and function of 17beta-hydroxysteroid dehydrogenase type 1 and type 2.
Molecular and cellular endocrinology 2001;171(1-2):71-6.
2000: M Miettinen; Veli Isomaa; Hellevi Peltoketo; Debashis Ghosh; Pirkko Vihko
Estrogen metabolism as a regulator of estrogen action in the mammary gland.
Journal of mammary gland biology and neoplasia 2000;5(3):259-70.
2000: William L Duax; Debashis Ghosh; Vladimir Pletnev
Steroid dehydrogenase structures, mechanism of action, and disease.
Vitamins and hormones 2000;58():121-48.
1999: N Li; Mary Erman; Walter Pangborn; William L Duax; C M Park; J Bruenn; Debashis Ghosh
Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore.
The Journal of biological chemistry 1999;274(29):20425-31.
1999: TJ Puranen; Riitta Kurkela; Jouni Lakkakorpi; Matti Poutanen; Petri Itäranta; J P Melis; Debashis Ghosh; RK Vihko; Pirkko Vihko
Characterization of molecular and catalytic properties of intact and truncated human 17beta-hydroxysteroid dehydrogenase type 2 enzymes: intracellular localization of the wild-type enzyme in the endoplasmic reticulum.
Endocrinology 1999;140(7):3334-41.
1999: M W Sawicki; P C Ng; BM Burkhart; Vladimir Pletnev; Tadayoshi Higashiyama; Yoshio Osawa; Debashis Ghosh
Structure of an activity suppressing Fab fragment to cytochrome P450 aromatase: insights into the antibody-antigen interactions.
Molecular immunology 1999;36(7):423-32.
1999: Debashis Ghosh; Mary Erman; M Sawicki; Puloma Lala; D R Weeks; N Li; Walter Pangborn; D J Thiel; H Jörnvall; R Gutierrez; J Eyzaguirre
Determination of a protein structure by iodination: the structure of iodinated acetylxylan esterase.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 4):779-84.
1999: M W Sawicki; N Li; Debashis Ghosh
Equilin.
Acta crystallographica. Section C, Crystal structure communications 1999;55 ( Pt 3)():425-7.
1999: M W Sawicki; M Erman; TJ Puranen; Pirkko Vihko; Debashis Ghosh
Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):840-5.
1999: Charles M Weeks; A W Roszak; Mary Erman; R Kaiser; H Jörnvall; Debashis Ghosh
Structure of rabbit liver fructose 1,6-bisphosphatase at 2.3 A resolution.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):93-102.
1997: TJ Puranen; Matti Poutanen; Debashis Ghosh; RK Vihko; Pirkko Vihko
Origin of substrate specificity of human and rat 17beta-hydroxysteroid dehydrogenase type 1, using chimeric enzymes and site-directed substitutions.
Endocrinology 1997;138(8):3532-9.
1997: William L Duax; Debashis Ghosh
Structure and function of steroid dehydrogenases involved in hypertension, fertility, and cancer.
Steroids 1997;62(1):95-100.
1997: TJ Puranen; Matti Poutanen; Debashis Ghosh; Pirkko Vihko; RK Vihko
Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis.
Molecular endocrinology (Baltimore, Md.) 1997;11(1):77-86.
1996: Sheng-Xiang Lin; DW Zhu; A Azzi; R L Campbell; R Breton; Fernand Labrie; Debashis Ghosh; Vladimir Pletnev; William L Duax; Walter Pangborn
Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase.
The Journal of endocrinology 1996;150 Suppl():S13-20.
1996: R Kaiser; H Olsson; Mary Erman; Charles M Weeks; Lars Hjelmqvist; Debashis Ghosh; Hans Jörnvall
Fructose-1,6-bisphosphatase. Primary structure of the rabbit liver enzyme. 'Intermediate' variability of an oligomeric protein.
FEBS letters 1996;389(3):249-52.
1996: Walter Pangborn; Mary Erman; N Li; BM Burkhart; Vladimir Pletnev; William L Duax; R Gutierrez; Alessandra Peirano; Jaime Eyzaguirre; D J Thiel; Debashis Ghosh
Characterization of crystals of Penicillium purpurogenum acetyl xylan esterase from high-resolution x-ray diffraction.
Proteins 1996;24(4):523-4.
1995: Debashis Ghosh; Z Wawrzak; Vladimir Pletnev; Mary Erman; William L Duax; Walter Pangborn; DW Zhu; Fernand Labrie; Sheng-Xiang Lin
Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function.
Annals of the New York Academy of Sciences 1995;761():341-3.
1995: Debashis Ghosh; Vladimir Pletnev; DW Zhu; Z Wawrzak; William L Duax; Walter Pangborn; Fernand Labrie; Sheng-Xiang Lin
Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution.
Structure (London, England : 1993) 1995;3(5):503-13.
1995: Debashis Ghosh; Z Wawrzak; Vladimir Pletnev; N Li; R Kaiser; Walter Pangborn; Hans Jörnvall; Mary Erman; William L Duax
Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase.
Structure (London, England : 1993) 1995;3(3):279-88.
1994: Debashis Ghosh; Mary Erman; Z Wawrzak; William L Duax; Walter Pangborn
Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor.
Structure (London, England : 1993) 1994;2(10):973-80.
1994: Debashis Ghosh; Z Wawrzak; Charles M Weeks; William L Duax; Mary Erman
The refined three-dimensional structure of 3 alpha,20 beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases.
Structure (London, England : 1993) 1994;2(7):629-40.
1994: R Kaiser; Mary Erman; William L Duax; Debashis Ghosh; Hans Jörnvall
Monomeric and dimeric forms of cholesterol esterase from Candida cylindracea. Primary structure, identity in peptide patterns, and additional microheterogeneity.
FEBS letters 1994;337(2):123-7.
1993: DW Zhu; Xavier Lee; R Breton; Debashis Ghosh; Walter Pangborn; W L Daux; Sheng-Xiang Lin
Crystallization and preliminary X-ray diffraction analysis of the complex of human placental 17 beta-hydroxysteroid dehydrogenase with NADP+.
Journal of molecular biology 1993;234(1):242-4.
1993: Debashis Ghosh; Mary Erman; Walter Pangborn; William L Duax; S Nakajin; S Ohno; M Shinoda
Crystallization and preliminary X-ray diffraction studies of a mammalian steroid dehydrogenase.
The Journal of steroid biochemistry and molecular biology 1993;46(1):103-4.
1992: Debashis Ghosh; Mary Erman; Walter Pangborn; William L Duax; M E Baker
Inhibition of Streptomyces hydrogenans 3 alpha,20 beta-hydroxysteroid dehydrogenase by licorice-derived compounds and crystallization of an enzyme-cofactor-inhibitor complex.
The Journal of steroid biochemistry and molecular biology 1992;42(8):849-53.
1991: Debashis Ghosh; Charles M Weeks; P Grochulski; William L Duax; Mary Erman; R L Rimsay; J C Orr
Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10064-8.
1991: Debashis Ghosh; Mary Erman; William L Duax
Crystallization and preliminary diffraction analysis of cholesterol esterase from Candida cylindracea.
The Journal of steroid biochemistry and molecular biology 1991;38(5):663-5.
1988: J S Punzi; Debashis Ghosh; Charles M Weeks; P Van Roey; William L Duax
Crystallization of prostatic binding protein.
Journal of steroid biochemistry 1988;31(4A):365-70.
1986: Debashis Ghosh; J S Punzi; William L Duax
Crystals of active tetramers of 3 alpha, 20 beta-hydroxysteroid dehydrogenase.
The Journal of biological chemistry 1986;261(3):1306-8.