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Adria Giacca
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23
Vranic, Mladen
22
Lewis, Gary
18
Shi, ZQ
11
Lam, Tony
11
Carpentier, André
9
Fisher, SJ
9
Goh, Tracy
9
Gupta, Neehar
8
Lam, Loretta
8
Fantus, George
7
Lickley, Lavina
7
Tchipashvili, Vaja
6
McCall, RH
6
Bruce, Robert
5
Efendic, Suad
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All Publications
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2009: Chen Jian; Chu Michael; Koulajian Khajag; Wu Xiao Yu; Giacca Adria; Sun Yu
A monolithic polymeric microdevice for pH-responsive drug delivery.
Biomedical microdevices 2009;11(6):1251-7.
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2009: Breen Danna M; Chan Kalam K; Dhaliwall Jiwanjeet K; Ward Michael R; Al Koudsi Nael; Lam Loretta; De Souza Melissa; Ghanim Husam; Dandona Paresh; Stewart Duncan J; Bendeck Michelle P; Giacca Adria
Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1060-6.
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2009: Chintoh Araba F; Mann Steve W; Lam Loretta; Giacca Adria; Fletcher Paul; Nobrega Jose; Remington Gary
Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal model.
Schizophrenia research 2009;108(1-3):127-33.
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2009: Duez Hélène; Smith Angela C; Xiao C; Giacca Adria; Szeto Linda; Drucker Daniel J; Lewis Gary F
Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.
Endocrinology 2009;150(1):56-62.
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2008: Chintoh Araba F; Mann Steve W; Lam Loretta; Lam Carol; Cohn Tony A; Fletcher Paul J; Nobrega Jose N; Giacca Adria; Remington Gary
Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration.
Journal of clinical psychopharmacology 2008;28(5):494-9.
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2008: Chintoh Araba F; Mann Steve W; Lam Tony K T; Giacca Adria; Remington Gary
Insulin resistance following continuous, chronic olanzapine treatment: an animal model.
Schizophrenia research 2008;104(1-3):23-30.
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2008: Diao Jingyu; Allister Emma M; Koshkin Vasilij; Lee Simon C; Bhattacharjee Alpana; Tang Christine; Giacca Adria; Chan Catherine B; Wheeler Michael B
UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):12057-62.
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2008: Szeto Ignatius M Y; Aziz Alfred; Das Paul J; Taha Ameer Y; Okubo Nobuhiko; Reza-Lopez Sandra; Giacca Adria; Anderson G Harvey
High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(2):R575-82.
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2008: Xiao C; Giacca A; Lewis G F
Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men.
Diabetologia 2008;51(1):139-46.
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2007: Oprescu Andrei I; Bikopoulos George; Naassan Anthony; Allister Emma M; Tang Christine; Park Edward; Uchino Hiroshi; Lewis Gary F; Fantus I George; Rozakis-Adcock Maria; Wheeler Michael B; Giacca Adria
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.
Diabetes 2007;56(12):2927-37.
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2007: Park Edward; Wong Victor; Guan Xinyu; Oprescu Andrei I; Giacca Adria
Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.
The Journal of endocrinology 2007;195(2):323-31.
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2007: Tang Christine; Han Ping; Oprescu Andrei I; Lee Simon C; Gyulkhandanyan Armen V; Chan Gary N Y; Wheeler Michael B; Giacca Adria
Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.
Diabetes 2007;56(11):2722-31.
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2007: Goh Tracy T; Mason Timothy M; Gupta Neehar; So Abby; Lam Tony K T; Lam Loretta; Lewis Gary F; Mari Andrea; Giacca Adria
Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.
American journal of physiology. Endocrinology and metabolism 2007;292(2):E549-60.
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2006: Gupta Neehar; Park Edward; Sandhu Harmanjit; Goh Tracy; Tchipashvili Vaja; Giacca Adria
Direct and indirect effects of insulin on hepatic glucose production in diabetic depancreatized dogs during euglycemia.
The Journal of endocrinology 2006;190(3):695-702.
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2006: Chen Shu; Lam Tony K T; Park Edward; Burdett Elena; Wang Penny Y T; Wiesenthal Stephanie R; Lam Loretta; Tchipashvili Vaja; Fantus I George; Giacca Adria
Oleate-induced decrease in hepatocyte insulin binding is mediated by PKC-delta.
Biochemical and biophysical research communications 2006;346(3):931-7.
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2006: Xiao C; Giacca A; Carpentier A; Lewis G F
Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans.
Diabetologia 2006;49(6):1371-9.
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2006: Yoshii Hidenori; Lam Tony K T; Gupta Neehar; Goh Tracy; Haber C Andrew; Uchino Hiroshi; Kim Tony T Y; Chong Victor Z; Shah Keyur; Fantus I George; Mari Andrea; Kawamori Ryuzo; Giacca Adria
Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1089-97.
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2006: Tran Thien T; Naigamwalla Dinaz; Oprescu Andrei I; Lam Loretta; McKeown-Eyssen Gail; Bruce W Robert; Giacca Adria
Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo.
Endocrinology 2006;147(4):1830-7.
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2005: Kim Tony; Chan Kalam K; Dhaliwall Jiwanjeet K; Huynh Nghia; Suen Renee; Uchino Hiroshi; Naigamwalla Dinaz; Bendeck Michelle P; Giacca Adria
Anti-atherogenic effect of insulin in vivo.
Journal of vascular research 2005;42(6):455-62.
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2005: Bruce W R; Cirocco M; Giacca A; Kim Y-I; Marcon N; Minkin S
A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation.
British journal of cancer 2005;93(6):639-46.
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2005: Uchino Hiroshi; Kim Tony; Lam Tony K T; Yoshii Hidenori; Klement Peter; Williams Wendy; Kawamori Ryuzo; Giacca Adria
FK-614, a selective peroxisome proliferator-activated receptor gamma agonist, improves peripheral glucose utilization while decreasing hepatic insulin extraction in alloxan-induced diabetic dogs.
Metabolism: clinical and experimental 2005;54(9):1250-8.
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2005: Aziz Alfred; Anderson G Harvey; Giacca Adria; Cho France
Hyperglycemia after protein ingestion concurrent with injection of a GLP-1 receptor agonist in rats: a possible role for dietary peptides.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(3):R688-94.
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2005: Wijesekara Nadeeja; Konrad Daniel; Eweida Mohamed; Jefferies Craig; Liadis Nicole; Giacca Adria; Crackower Mike; Suzuki Akira; Mak Tak W; Kahn C Ronald; Klip Amira; Woo Minna
Muscle-specific Pten deletion protects against insulin resistance and diabetes.
Molecular and cellular biology 2005;25(3):1135-45.
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2005: Lin Ying; Berg Anders H; Iyengar Puneeth; Lam Tony K T; Giacca Adria; Combs Terry P; Rajala Michael W; Du Xueliang; Rollman Brent; Li Weijie; Hawkins Meredith; Barzilai Nir; Rhodes Christopher J; Fantus I George; Brownlee Michael; Scherer Philipp E
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
The Journal of biological chemistry 2005;280(6):4617-26.
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2004: Leung N; Sakaue T; Carpentier A; Uffelman K; Giacca A; Lewis G F
Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men.
Diabetologia 2004;47(2):204-13.
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2004: Wang Xiaolin; Li Hui; De Leo Domenica; Guo Wanbei; Koshkin Vasilij; Fantus I George; Giacca Adria; Chan Catherine B; Der Sandy; Wheeler Michael B
Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.
Diabetes 2004;53(1):129-40.
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2003: Haber C Andrew; Lam Tony K T; Yu Zhiwen; Gupta Neehar; Goh Tracy; Bogdanovic Elena; Giacca Adria; Fantus I George
N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress.
American journal of physiology. Endocrinology and metabolism 2003;285(4):E744-53.
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2003: Carpentier André; Zinman Bernard; Leung Nathalie; Giacca Adria; Hanley Anthony J G; Harris Stewart B; Hegele Robert A; Lewis Gary F
Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes.
Diabetes 2003;52(6):1485-95.
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2003: Lam Tony K T; Carpentier André; Lewis Gary F; van de Werve Gérald; Fantus I George; Giacca Adria
Mechanisms of the free fatty acid-induced increase in hepatic glucose production.
American journal of physiology. Endocrinology and metabolism 2003;284(5):E863-73.
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2003: Wang Chao-Hung; Leung Nathalie; Lapointe Nathalie; Szeto Linda; Uffelman Kristine D; Giacca Adria; Rouleau Jean L; Lewis Gary F
Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I receptor blocker.
Circulation 2003;107(14):1923-9.
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2003: Lam Tony K T; van de Werve Gérald; Giacca Adria
Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites.
American journal of physiology. Endocrinology and metabolism 2003;284(2):E281-90.
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2003: Tran Thien T; Gupta Neehar; Goh Tracy; Naigamwalla Dinaz; Chia Marie C; Koohestani Niloofar; Mehrotra Shruti; McKeown-Eyssen Gail; Giacca Adria; Bruce W Robert
Direct measure of insulin sensitivity with the hyperinsulinemic-euglycemic clamp and surrogate measures of insulin sensitivity with the oral glucose tolerance test: correlations with aberrant crypt foci promotion in rats.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(1):47-56.
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2002: Gupta Neehar; Sandhu Harmanjit; Goh Tracy; Shah Keyur; Wiesenthal Stephanie R; Yoshii Hidenori; Chong Victor; Lam Tony K T; Haber C Andrew; Williams Wendy; Tchipashvili Vaja; Giacca Adria
Insulin inhibits glucose production by a direct effect in diabetic depancreatized dogs during euglycemia.
American journal of physiology. Endocrinology and metabolism 2002;283(5):E1002-7.
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2002: Lam Tony K T; Yoshii Hidenori; Haber C Andrew; Bogdanovic Elena; Lam Loretta; Fantus I George; Giacca Adria
Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta.
American journal of physiology. Endocrinology and metabolism 2002;283(4):E682-91.
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2002: Dobbins Robert L; Szczepaniak Lidia S; Myhill Jeff; Tamura Yoshifumi; Uchino Hiroshi; Giacca Adria; McGarry J Denis
The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats.
Diabetes 2002;51(6):1825-33.
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2002: Lewis Gary F; Carpentier André; Adeli Khosrow; Giacca Adria
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes.
Endocrine reviews 2002;23(2):201-29.
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2002: Mason T M; Chan B; El-Bahrani B; Goh T; Gupta N; Gamble J; Qing Shi Z; Prentki M; Steiner G; Giacca Adria
The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats.
Atherosclerosis 2002;161(2):345-52.
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2002: Bruce W R; Giacca A; Medline A
Possible mechanisms relating diet to colorectal cancer risk.
IARC scientific publications 2002;156():277-81.
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2001: Carpentier A; Giacca A; Lewis G F
Effect of increased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans.
Diabetologia 2001;44(11):1989-97.
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2001: Carpentier A; Patterson B W; Uffelman K D; Giacca A; Vranic M; Cattral M S; Lewis G F
The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism.
Diabetes 2001;50(6):1402-13.
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2001: Fisher S J; Shi Z Q; Lickley H L; Efendic S; Vranic M; Giacca A
Low-dose IGF-I has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic depancreatized dogs.
The Journal of endocrinology 2001;168(1):49-58.
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2000: Bruce W R; Giacca A; Medline A
Possible mechanisms relating diet and risk of colon cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(12):1271-9.
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2000: Mason T M; Gupta N; Goh T; El-Bahrani B; Zannis J; van de Werve G; Giacca A
Chronic intraperitoneal insulin delivery, as compared with subcutaneous delivery, improves hepatic glucose metabolism in streptozotocin diabetic rats.
Metabolism: clinical and experimental 2000;49(11):1411-6.
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2000: Wan C K; Giacca A; Matsuhisa M; El-Bahrani B; Lam L; Rodgers C; Shi Z Q
Increased responses of glucagon and glucose production to hypoglycemia with intraperitoneal versus subcutaneous insulin treatment.
Metabolism: clinical and experimental 2000;49(8):984-9.
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2000: Niwa M; Rashid S; Shum K; Mathoo J M; Chan O; Tchipashvili V; Kawamori R; Vranic M; Giacca A
Effect of JTT-501 on net hepatic glucose balance and peripheral glucose uptake in alloxan-induced diabetic dogs.
Metabolism: clinical and experimental 2000;49(7):862-7.
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2000: Carpentier A; Mittelman S D; Bergman R N; Giacca A; Lewis G F
Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.
Diabetes 2000;49(3):399-408.
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2000: Bruce W R; Wolever T M; Giacca A
Mechanisms linking diet and colorectal cancer: the possible role of insulin resistance.
Nutrition and cancer 2000;37(1):19-26.
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1999: Carpentier A; Mittelman S D; Lamarche B; Bergman R N; Giacca A; Lewis G F
Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation.
The American journal of physiology 1999;276(6 Pt 1):E1055-66.
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1999: Sandhu H; Wiesenthal S R; MacDonald P E; McCall R H; Tchipashvili V; Rashid S; Satkunarajah M; Irwin D M; Shi Z Q; Brubaker P L; Wheeler M B; Vranic M; Efendic S; Giacca A
Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs.
Diabetes 1999;48(5):1045-53.
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1999: Wiesenthal S R; Sandhu H; McCall R H; Tchipashvili V; Yoshii H; Polonsky K; Shi Z Q; Lewis G F; Mari A; Giacca A
Free fatty acids impair hepatic insulin extraction in vivo.
Diabetes 1999;48(4):766-74.
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1999: Lewis G F; Carpentier A; Bilinski D; Giacca A; Vranic M
Counterregulatory response to hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans.
The Journal of clinical endocrinology and metabolism 1999;84(3):1037-46.
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1999: Lewis G F; Carpentier A; Vranic M; Giacca A
Resistance to insulin's acute direct hepatic effect in suppressing steady-state glucose production in individuals with type 2 diabetes.
Diabetes 1999;48(3):570-6.
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1999: Mason T M; Goh T; Tchipashvili V; Sandhu H; Gupta N; Lewis G F; Giacca A
Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats.
Diabetes 1999;48(3):524-30.
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1999: Giacca A; McCall R; Chan B; Shi Z Q
Increased dependence of glucose production on peripheral insulin in diabetic depancreatized dogs.
Metabolism: clinical and experimental 1999;48(2):153-60.
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1998: Giacca A; Groenewoud Y; Tsui E; McClean P; Zinman B
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia.
Diabetes 1998;47(11):1763-70.
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1998: Lewis G F; Vranic M; Giacca A
Role of free fatty acids and glucagon in the peripheral effect of insulin on glucose production in humans.
The American journal of physiology 1998;275(1 Pt 1):E177-86.
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1998: McCall R H; Wiesenthal S R; Shi Z Q; Polonsky K; Giacca A
Insulin acutely suppresses glucose production by both peripheral and hepatic effects in normal dogs.
The American journal of physiology 1998;274(2 Pt 1):E346-56.
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1997: Fisher S J; Lekas M; Shi Z Q; Bilinski D; Carvalho G; Giacca A; Vranic M
Insulin-independent acute restoration of euglycemia normalizes the impaired glucose clearance during exercise in diabetic dogs.
Diabetes 1997;46(11):1805-12.
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1997: Lewis G F; Vranic M; Harley P; Giacca A
Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans.
Diabetes 1997;46(7):1111-9.
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1997: Lewis G F; Vranic M; Giacca A
Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans.
The American journal of physiology 1997;272(3 Pt 1):E371-8.
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1997: Giacca A; Fisher S J; McCall R H; Shi Z Q; Vranic M
Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: role of glucagon.
Endocrinology 1997;138(3):999-1007.
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1997: Matsuhisa M; Shi Z Q; Wan C; Lekas M; Rodgers C D; Giacca A; Kawamori R; Vranic M
The effect of pioglitazone on hepatic glucose uptake measured with indirect and direct methods in alloxan-induced diabetic dogs.
Diabetes 1997;46(2):224-31.
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1996: Fisher S J; Shi Z Q; Lickley H L; Efendic S; Vranic M; Giacca A
A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp.
Metabolism: clinical and experimental 1996;45(5):587-93.
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1996: Fisher S J; Lekas M C; McCall R H; Shi Z Q; Giacca A; Vranic M
Determinants of glucose turnover in the pathophysiology of diabetes: an in vivo analysis in diabetic dogs.
Diabetes & metabolism 1996;22(2):111-21.
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1996: Lewis G F; Zinman B; Groenewoud Y; Vranic M; Giacca A
Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans.
Diabetes 1996;45(4):454-62.
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1994: Shi Z Q; Giacca A; Fisher S; Vidal H; van de Werve G; Vranic M
Importance of substrate changes in the decrease of hepatic glucose cycling during insulin infusion and declining glycemia in the depancreatized dog.
Diabetes 1994;43(11):1284-90.
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1994: Giacca A; Fisher S J; Shi Z Q; Gupta R; Lickley H L; Skottner A; Anderson G H; Efendic S; Vranic M
Insulin-like growth factor-I and insulin have no differential effects on glucose production and utilization under conditions of hyperglycemia.
Endocrinology 1994;134(5):2251-8.
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1993: Shi Z Q; Giacca A; Yamatani K; Fisher S J; Lickley H L; Vranic M
Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs.
The American journal of physiology 1993;264(3 Pt 1):E334-41.
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1993: Shi Z Q; Giacca A; Fisher S J; Lekas M; Bilinski D; Van Delangeryt M; Lickley H L; Vranic M
Indirect effects of insulin in regulating glucose fluxes.
Advances in experimental medicine and biology 1993;334():151-68.
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1992: Klip A; Marette A; Dimitrakoudis D; Ramlal T; Giacca A; Shi Z Q; Vranic M
Effect of diabetes on glucoregulation. From glucose transporters to glucose metabolism in vivo.
Diabetes care 1992;15(11):1747-66.
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1992: Giacca A; Fisher S J; Shi Z Q; Gupta R; Lickley H L; Vranic M
Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs.
The Journal of clinical investigation 1992;90(5):1769-77.
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1992: Yamatani K; Shi Z Q; Giacca A; Gupta R; Fisher S; Lickley H L; Vranic M
Role of FFA-glucose cycle in glucoregulation during exercise in total absence of insulin.
The American journal of physiology 1992;263(4 Pt 1):E646-53.
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1990: Giacca A; Gupta R; Efendic S; Hall K; Skottner A; Lickley L; Vranic M
Differential effects of IGF-I and insulin on glucoregulation and fat metabolism in depancreatized dogs.
Diabetes 1990;39(3):340-7.
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