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Amato Giaccia

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Edward L LaGory; Amato J Giaccia
A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: the Atkins diet suppresses tumor growth.
Olga Catalina-Rodriguez; Amato J Giaccia; Eric Glasgow; Vamsi K Kolukula; Ferdinando Palmieri; Anju Preet; York Tomita; Anton Wellstein; Chris Albanese; Stephen Byers; Maria Laura Avantaggiati
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.
Eric Jonasch; William Y Kim; Ghada Kurban; Armin Pause; Michael B Atkins; Sean T Bailey; James Brugarolas; Ian J Davis; Judith Frydman; P Andrew Futreal; Amato J Giaccia; Brian I Rini; Pam Sharma; Cheryl L Walker; Amado J Zurita; W Kimryn Rathmell
State of the science: an update on renal cell carcinoma.

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2013: Edward L LaGory; Amato J Giaccia
A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: the Atkins diet suppresses tumor growth.
Cell cycle (Georgetown, Tex.) 2013;12(5):718-9.
2012: Olga Catalina-Rodriguez; Amato J Giaccia; Eric Glasgow; Vamsi K Kolukula; Ferdinando Palmieri; Anju Preet; York Tomita; Anton Wellstein; Chris Albanese; Stephen Byers; Maria Laura Avantaggiati
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.
Oncotarget 2012;3(10):1220-35.
2012: Eric Jonasch; William Y Kim; Ghada Kurban; Armin Pause; Michael B Atkins; Sean T Bailey; James Brugarolas; Ian J Davis; Judith Frydman; P Andrew Futreal; Amato J Giaccia; Brian I Rini; Pam Sharma; Cheryl L Walker; Amado J Zurita; W Kimryn Rathmell
State of the science: an update on renal cell carcinoma.
Molecular cancer research : MCR 2012;10(7):859-80.
2012: Colleen Wu; Erinn B Rankin; Amato J Giaccia
Blood and bones: osteoblastic HIF signaling regulates erythropoiesis.
Cell cycle (Georgetown, Tex.) 2012;11(12):2221-2.
2012: Erinn B Rankin; Ernestina Schipani; Tremika L S Wilson; Colleen Wu; Jenny Yuan; Rebecca Andersen; Elisa Araldi; Richa Khatri; Calvin J Kuo; Andrew L Rankin; Amato J Giaccia
The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.
Cell 2012;149(1):63-74.
2012: Christa Maes; Riet Van Looveren; Elisa Araldi; Geert Carmeliet; Amato J Giaccia; Jody J Haigh; Katharina Haigh; Richa Khatri; Ernestina Schipani
VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(3):596-609.
2011: Mei Huang; Fangjun Jia; Mark A Kay; Divya Nag; Patricia Nguyen; Robert C Robbins; Li Wang; Patricia E de Almeida; Amato J Giaccia; Yongquan Gong; Shijun Hu; Joseph C Wu
Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction.
Circulation 2011;124(11 Suppl):S46-54.
2011: Denise A Chan; Jen-Tsan Chi; William A Denny; Jack U Flanagan; Alice Banh; Muriel Bonnet; Donna M Bouley; Edward Graves; Michael Hay; Edwin W Lai; Phuong Nguyen; Gloria E Reynolds; David E Solow-Cordero; Patrick D Sutphin; Sandra Turcotte; Jason Wu; Amato J Giaccia
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality.
Science translational medicine 2011;3(94):94ra70.
2011: Alice Banh; Donna M Bouley; Hongbin Cao; Amato J Giaccia; Christina Kong; Albert C Koong; Shirley Kwok; Jing Zhang; Quynh-Thu Le
Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis.
Cancer research 2011;71(13):4423-31.
2011: Muriel Bonnet; Jack U Flanagan; Denise A Chan; Edwin W Lai; Phuong Nguyen; Amato J Giaccia; Michael Hay
SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells.
Bioorganic & medicinal chemistry 2011;19(11):3347-56.
2011: Erinn B Rankin; Amato J Giaccia; Ernestina Schipani
A central role for hypoxic signaling in cartilage, bone, and hematopoiesis.
Current osteoporosis reports 2011;9(2):46-52.
2011: Denise A Chan; Amato J Giaccia
Harnessing synthetic lethal interactions in anticancer drug discovery.
Nature reviews. Drug discovery 2011;10(5):351-64.
2011: Scott M Welford; Amato J Giaccia
Hypoxia and senescence: the impact of oxygenation on tumor suppression.
Molecular cancer research : MCR 2011;9(5):538-44.
2011: Olga V Razorenova; Elizabeth C Finger; Renata Colavitti; Sophia B Chernikova; Alexander D Boiko; Charles K F Chan; Adam Krieg; Barbara Bedogni; Edward LaGory; Irving L Weissman; Marianne Broome-Powell; Amato J Giaccia
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(5):1931-6.
2011: Elisa Araldi; Richa Khatri; Amato J Giaccia; M Celeste Simon; Ernestina Schipani
Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development.
Nature medicine 2011;17(1):25-6; author reply 27-9.
2011: Nikolay B Pestov; Irina A Okkelman; Vadim V Shmanai; Alaksiej L Hurski; Amato J Giaccia; Mikhail S Shchepinov
Control of lysyl oxidase activity through site-specific deuteration of lysine.
Bioorganic & medicinal chemistry letters 2011;21(1):255-8.
2010: Edward Graves; Marta Vilalta; Ivana K Cecic; Janine T Erler; Phuoc Tran; Dean W Felsher; Leanne Sayles; Alejandro Sweet-Cordero; Quynh-Thu Le; Amato J Giaccia
Hypoxia in models of lung cancer: implications for targeted therapeutics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(19):4843-52.
2010: Erinn B Rankin; Katherine C Fuh; Tiffany E Taylor; Adam J Krieg; Margaret Musser; Jenny Yuan; Kevin Wei; Calvin J Kuo; Teri A Longacre; Amato J Giaccia
AXL is an essential factor and therapeutic target for metastatic ovarian cancer.
Cancer research 2010;70(19):7570-9.
2010: Scott M Welford; Mary Jo Dorie; Xiaofeng Li; Volker H Haase; Amato J Giaccia
Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress.
Molecular and cellular biology 2010;30(19):4595-603.
2010: David A Patten; Véronique N Lafleur; Geneviève A Robitaille; Denise A Chan; Amato J Giaccia; Darren E Richard
Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species.
Molecular biology of the cell 2010;21(18):3247-57.
2010: Mandi Wiley; Kristin R Sweeney; Denise A Chan; Kevin M Brown; Curtis McMurtrey; Eric W Howard; Amato J Giaccia; Ira J Blader
Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.
The Journal of biological chemistry 2010;285(35):26852-60.
2010: Elizabeth C Finger; Amato J Giaccia
Hypoxia, inflammation, and the tumor microenvironment in metastatic disease.
Cancer metastasis reviews 2010;29(2):285-93.
2010: Xin Huang; Quynh-Thu Le; Amato J Giaccia
MiR-210--micromanager of the hypoxia pathway.
Trends in molecular medicine 2010;16(5):230-7.
2010: Sandra Turcotte; Amato J Giaccia
Targeting cancer cells through autophagy for anticancer therapy.
Current opinion in cell biology 2010;22(2):246-51.
2010: Michael Hay; Sandra Turcotte; Jack U Flanagan; Muriel Bonnet; Denise A Chan; Patrick D Sutphin; Phuong Nguyen; Amato J Giaccia; William A Denny
4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death.
Journal of medicinal chemistry 2010;53(2):787-97.
2010: Amato J Giaccia; Ernestina Schipani
Role of carcinoma-associated fibroblasts and hypoxia in tumor progression.
Current topics in microbiology and immunology 2010;345():31-45.
2010: Adam J Krieg; Erinn B Rankin; Denise Chan; Olga Razorenova; Sully Fernandez; Amato J Giaccia
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.
Molecular and cellular biology 2010;30(1):344-53.
2009: Rob A Cairns; Kevin L Bennewith; Edward E Graves; Amato J Giaccia; Daniel T Chang; Nicholas C Denko
Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(23):7170-4.
2009: Yue Xu; Kyle E Hammerick; Aaron James; Antoine L Carre; Philipp Leucht; Amato J Giaccia; Michael T Longaker
Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells.
Tissue engineering. Part A 2009;15(12):3697-707.
2009: Carlotta Granchi; Tiziana Funaioli; Janine T Erler; Amato J Giaccia; Marco Macchia; Filippo Minutolo
Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours.
ChemMedChem 2009;4(10):1590-4.
2009: Xin Huang; Lianghao Ding; Kevin L Bennewith; Ricky T Tong; Scott M Welford; K Kian Ang; Michael Story; Quynh-Thu Le; Amato J Giaccia
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.
Molecular cell 2009;35(6):856-67.
2009: Quynh-Thu Le; Jonathan Harris; anthony magliocco; Christina S Kong; Roman Diaz; Brian Shin; Hongbin Cao; Andy Trotti; Janine T Erler; Christine H Chung; Adam Dicker; Thomas F Pajak; Amato J Giaccia; K Kian Ang
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(26):4281-6.
2009: Denise A Chan; Tiara L A Kawahara; Patrick D Sutphin; Howard Y Chang; Jen-Tsan Chi; Amato J Giaccia
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
Cancer cell 2009;15(6):527-38.
2009: Erinn B Rankin; Amato J Giaccia; Ester M Hammond
Bringing H2AX into the angiogenesis family.
Cancer cell 2009;15(6):459-61.
2009: Asish K Ghosh; Tait D Shanafelt; Amelia Cimmino; Cristian Taccioli; Stefano Volinia; Chang-gong liu; George A Calin; Carlo M Croce; Denise A Chan; Amato J Giaccia; Charla Secreto; Linda E Wellik; Yean K Lee; Debabrata Mukhopadhyay; Neil E Kay
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells.
Blood 2009;113(22):5568-74.
2009: Kevin L Bennewith; Xin Huang; Christine M Ham; Edward Graves; Janine T Erler; Neeraja Kambham; Jonathan Feazell; George P Yang; Albert C Koong; Amato J Giaccia
The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth.
Cancer research 2009;69(3):775-84.
2009: Janine T Erler; Kevin L Bennewith; Thomas R Cox; Georgina Lang; Demelza Bird; Albert C Koong; Quynh-Thu Le; Amato J Giaccia
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.
Cancer cell 2009;15(1):35-44.
2009: Zuzana Bencokova; Muriel R Kaufmann; Isabel M Pires; Philip S Lecane; Amato J Giaccia; Ester M Hammond
ATM activation and signaling under hypoxic conditions.
Molecular and cellular biology 2009;29(2):526-37.
2008: Barbara Bedogni; James A Warneke; Brian J Nickoloff; Amato J Giaccia; Marianne Powell
Notch1 is an effector of Akt and hypoxia in melanoma development.
The Journal of clinical investigation 2008;118(11):3660-70.
2008: Denise A Chan; Amato J Giaccia
Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics.
Cell cycle (Georgetown, Tex.) 2008;7(19):2987-90.
2008: Sandra Turcotte; Patrick D Sutphin; Amato J Giaccia
Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death.
Autophagy 2008;4(7):944-6.
2008: Mei Huang; Denise A Chan; Fangjun Jia; Xiaoyan Xie; Zongjin Li; Grant Hoyt; Robert C Robbins; Xiaoyuan Chen; Amato J Giaccia; Joseph C Wu
Short hairpin RNA interference therapy for ischemic heart disease.
Circulation 2008;118(14 Suppl):S226-33.
2008: Sandra Turcotte; Denise A Chan; Patrick D Sutphin; Michael Hay; William A Denny; Amato J Giaccia
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.
Cancer cell 2008;14(1):90-102.
2008: Marie-Claude Lauzier; Geneviève A Robitaille; Denise A Chan; Amato J Giaccia; Darren E Richard
(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors.
Molecular pharmacology 2008;74(1):282-8.
2008: Shashwati Basak; Suzanne B R Jacobs; Adam J Krieg; Navneeta Pathak; Qi Zeng; Philipp Kaldis; Amato J Giaccia; Laura D Attardi
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation.
Molecular cell 2008;30(3):303-14.
2008: Clara Y H Choi; Denise A Chan; Ramasamy Paulmurugan; Patrick D Sutphin; Quynh-Thu Le; Albert C Koong; Wayne Zundel; Sanjiv S Gambhir; Amato J Giaccia
Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice.
Molecular imaging 2008;7(3):139-46.
2008: E B Rankin; Amato J Giaccia
The role of hypoxia-inducible factors in tumorigenesis.
Cell death and differentiation 2008;15(4):678-85.
2008: Elisabeth L Pagé; Denise A Chan; Amato J Giaccia; Mark Levine; Darren E Richard
Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.
Molecular biology of the cell 2008;19(1):86-94.
2007: Edward I Chang; Shang A Loh; Daniel J Ceradini; Edward I Chang; Shin-e Lin; Nicholas Bastidas; Shahram Aarabi; Denise A Chan; Michael L Freedman; Amato J Giaccia; Geoffrey C Gurtner
Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia.
Circulation 2007;116(24):2818-29.
2007: Ester M Hammond; Muriel R Kaufmann; Amato J Giaccia
Oxygen sensing and the DNA-damage response.
Current opinion in cell biology 2007;19(6):680-4.
2007: Yue Xu; Preeti Malladi; Michael Chiou; Elena Bekerman; Amato J Giaccia; Michael T Longaker
In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis.
Tissue engineering 2007;13(12):2981-93.
2007: Quynh-Thu Le; Christina Kong; Philip W Lavori; Ken O'byrne; Janine T Erler; Xin Huang; Yijun Chen; Hongbin Cao; Robert Tibshirani; Nicholas C Denko; Amato J Giaccia; Albert C Koong
Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas.
International journal of radiation oncology, biology, physics 2007;69(1):167-75.
2007: Ivana Cecic; Denise A Chan; Patrick D Sutphin; Pritha Ray; Sanjiv S Gambhir; Amato J Giaccia; Edward Graves
Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia.
Molecular imaging 2007;6(4):219-28.
2007: Patrick D Sutphin; Denise A Chan; James M Li; Sandra Turcotte; Adam J Krieg; Amato J Giaccia
Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells.
Cancer research 2007;67(12):5896-905.
2007: Patrick D Sutphin; Amato J Giaccia; Denise A Chan
Energy regulation: HIF MXIes it up with the C-MYC powerhouse.
Developmental cell 2007;12(6):845-6.
2007: Preeti Malladi; Yue Xu; Michael Chiou; Amato J Giaccia; Michael T Longaker
Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells.
Tissue engineering 2007;13(6):1159-71.
2007: Denise A Chan; Amato J Giaccia
Hypoxia, gene expression, and metastasis.
Cancer metastasis reviews 2007;26(2):333-9.
2007: Sylvain Provot; Dawn Zinyk; Yasemin Gunes; Richa Kathri; Quynh Le; Henry M Kronenberg; Randall S Johnson; Michael T Longaker; Amato J Giaccia; Ernestina Schipani
Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.
The Journal of cell biology 2007;177(3):451-64.
2007: Edward Graves; Amato J Giaccia
Imaging tumoral hypoxia: oxygen concentrations and beyond.
Oncology (Williston Park, N.Y.) 2007;21(3):368-76; discussion 377-8, 384.
2007: Yi Pan; Kyle D Mansfield; Cara C Bertozzi; Viktoriya Rudenko; Denise A Chan; Amato J Giaccia; M Celeste Simon
Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.
Molecular and cellular biology 2007;27(3):912-25.
2007: Denise A Chan; Adam J Krieg; Sandra Turcotte; Amato J Giaccia
HIF gene expression in cancer therapy.
Methods in enzymology 2007;435():323-45.
2006: Scott M Welford; Barbara Bedogni; Katarina Gradin; Lorenz Poellinger; Marianne Broome Powell; Amato J Giaccia
HIF1alpha delays premature senescence through the activation of MIF.
Genes & development 2006;20(24):3366-71.
2006: David Petrik; Philip W Lavori; Hongbin Cao; Yonghua Zhu; Priscilla Wong; Erin Christofferson; Michael J Kaplan; Harlan A Pinto; Patrick D Sutphin; Albert C Koong; Amato J Giaccia; Quynh-Thu Le
Plasma osteopontin is an independent prognostic marker for head and neck cancers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(33):5291-7.
2006: Janine T Erler; Amato J Giaccia
Lysyl oxidase mediates hypoxic control of metastasis.
Cancer research 2006;66(21):10238-41.
2006: Adam J Krieg; Ester M Hammond; Amato J Giaccia
Functional analysis of p53 binding under differential stresses.
Molecular and cellular biology 2006;26(19):7030-45.
2006: Ester M Hammond; Amato J Giaccia
Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers?
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(17):5007-9.
2006: Ester M Hammond; Rachel A Freiberg; Amato J Giaccia
The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation.
Cancer letters 2006;238(2):161-7.
2006: Rachel A Freiberg; Adam J Krieg; Amato J Giaccia; Ester M Hammond
Checking in on hypoxia/reoxygenation.
Cell cycle (Georgetown, Tex.) 2006;5(12):1304-7.
2006: Nadja Dornhöfer; Suzanne Spong; Kevin Bennewith; Ali Salim; Stephen Klaus; Neeraja Kambham; Carol Wong; Fiona Kaper; Patrick D Sutphin; Randall P Nacamuli; Rendall Nacalumi; Michael Höckel; Quynh Le; Michael Longaker; George Yang; Albert C Koong; Amato J Giaccia
Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis.
Cancer research 2006;66(11):5816-27.
2006: Ester M Hammond; Daniel J Mandell; Ali Salim; Adam J Krieg; Thomas M Johnson; Haider A Shirazi; Laura D Attardi; Amato J Giaccia
Genome-wide analysis of p53 under hypoxic conditions.
Molecular and cellular biology 2006;26(9):3492-504.
2006: Janine T Erler; Kevin L Bennewith; Monica Nicolau; Nadja Dornhöfer; Christina Kong; Quynh-Thu Le; Jen-Tsan Chi; Stefanie S Jeffrey; Amato J Giaccia
Lysyl oxidase is essential for hypoxia-induced metastasis.
Nature 2006;440(7088):1222-6.
2006: Preeti Malladi; Yue Xu; Michael Chiou; Amato J Giaccia; Michael T Longaker
Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells.
American journal of physiology. Cell physiology 2006;290(4):C1139-46.
2006: Quynh-Thu Le; Eunice Chen; Ali Salim; Hongbin Cao; Christina S Kong; Richard I Whyte; Jessica S Donington; Walter Cannon; Heather A Wakelee; Robert Tibshirani; John D Mitchell; Donna Richardson; Ken J O'Byrne; Albert C Koong; Amato J Giaccia
An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1507-14.
2006: Rachel A Freiberg; Ester M Hammond; Mary Jo Dorie; Scott M Welford; Amato J Giaccia
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
Molecular and cellular biology 2006;26(5):1598-609.
2006: Jen-Tsan Chi; Zhen Wang; Dimitry S A Nuyten; Edwin H Rodriguez; Marci E Schaner; Ali Salim; Yun Wang; Gunnar Kristensen; Aslaug Helland; Anne-Lise Børresen-Dale; Amato J Giaccia; Michael T Longaker; Trevor Hastie; George P Yang; Marc J van de Vijver; Patrick O Brown
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.
PLoS medicine 2006;3(3):e47.
2006: Fiona Kaper; Nadja Dornhoefer; Amato J Giaccia
Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions.
Cancer research 2006;66(3):1561-9.
2006: Quynh-Thu Le; Hongbin Cao; Albert C Koong; Amato J Giaccia
Comment on: osteopontin as toxic marker.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2006;78(2):230; author reply 230-1.
2006: Wade Spear; Denise Chan; Isabelle Coppens; Randall S Johnson; Amato J Giaccia; Ira J Blader
The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels.
Cellular microbiology 2006;8(2):339-52.
2005: Quynh-Thu Le; Gongyi Shi; Hongbin Cao; Daniel W Nelson; Yingyun Wang; Eunice Y Chen; Shuchun Zhao; Christina Kong; Donna Richardson; Ken J O'Byrne; Amato J Giaccia; Albert C Koong
Galectin-1: a link between tumor hypoxia and tumor immune privilege.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(35):8932-41.
2005: Barbara Bedogni; Scott M Welford; David S Cassarino; Brian J Nickoloff; Amato J Giaccia; Marianne Powell
The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation.
Cancer cell 2005;8(6):443-54.
2005: Yonghua Zhu; David T Denhardt; Hongbin Cao; Patrick D Sutphin; Albert C Koong; Amato J Giaccia; Quynh-Thu Le
Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer.
Oncogene 2005;24(43):6555-63.
2005: Denise A Chan; Patrick D Sutphin; Shing-Erh Yen; Amato J Giaccia
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.
Molecular and cellular biology 2005;25(15):6415-26.
2005: Daniel W Nelson; Hongbin Cao; Yonghua Zhu; Bulbin Sunar-Reeder; Clara Y H Choi; James D Faix; J Martin Brown; Albert C Koong; Amato J Giaccia; Quynh-Thu Le
A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.
Cancer research 2005;65(14):6151-8.
2005: Tony D Fang; Ali Salim; Wei Xia; Randall P Nacamuli; Samira Guccione; HanJoon M Song; Richard A D Carano; Ellen H Filvaroff; Mark D Bednarski; Amato J Giaccia; Michael T Longaker
Angiogenesis is required for successful bone induction during distraction osteogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(7):1114-24.
2005: Ester M Hammond; Amato J Giaccia
The role of p53 in hypoxia-induced apoptosis.
Biochemical and biophysical research communications 2005;331(3):718-25.
2005: Ioanna Papandreou; Chaya Krishna; Fiona Kaper; Deli Cai; Amato J Giaccia; Nicholas C Denko
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment.
Cancer research 2005;65(8):3171-8.
2005: Zhong Yun; Qun Lin; Amato J Giaccia
Adaptive myogenesis under hypoxia.
Molecular and cellular biology 2005;25(8):3040-55.
2005: Jin Hyen Baek; Patrick C Mahon; Jane Oh; Brian Kelly; Balaji Krishnamachary; Mia Pearson; Denise A Chan; Amato J Giaccia; Gregg L Semenza
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Molecular cell 2005;17(4):503-12.
2005: Thomas M Johnson; Ester M Hammond; Amato J Giaccia; Laura D Attardi
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality.
Nature genetics 2005;37(2):145-52.
2004: Yijun Chen; Gongyi Shi; Wei Xia; Christina Kong; Shuchun Zhao; Allison F Gaw; Eunice Y Chen; George P Yang; Amato J Giaccia; Quynh-Thu Le; Albert C Koong
Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling.
Cancer research 2004;64(20):7302-10.
2004: Damien Gerald; Edurne Berra; Yves-Michel Frapart; Denise A Chan; Amato J Giaccia; Daniel Mansuy; Jacques Pouysségur; Moshe Yaniv; Fatima Mechta-Grigoriou
JunD reduces tumor angiogenesis by protecting cells from oxidative stress.
Cell 2004;118(6):781-94.
2004: Ali Salim; Randall P Nacamuli; Elise F Morgan; Amato J Giaccia; Michael T Longaker
Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts.
The Journal of biological chemistry 2004;279(38):40007-16.
2004: Ester M Hammond; Mary Jo Dorie; Amato J Giaccia
Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation.
Cancer research 2004;64(18):6556-62.
2004: Amato J Giaccia; M Celeste Simon; Randall Johnson
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.
Genes & development 2004;18(18):2183-94.
2004: Jacques Bernier; Eric J Hall; Amato J Giaccia
Radiation oncology: a century of achievements.
Nature reviews. Cancer 2004;4(9):737-47.
2004: Lorenzo Romero-Ramirez; Hongbin Cao; Daniel Nelson; Ester Hammond; Ann-Hwee Lee; Hiderou Yoshida; Kazutoshi Mori; Laurie H Glimcher; Nicholas C Denko; Amato J Giaccia; Quynh-Thu Le; Albert C Koong
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
Cancer research 2004;64(17):5943-7.
2004: S-T Joseph Huang; Kim Chi Vo; Deirdre J Lyell; Gerry H Faessen; Suzana Tulac; R Tibshirani; Amato J Giaccia; Linda C Giudice
Developmental response to hypoxia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1348-65.
2004: Ester M Hammond; Amato J Giaccia
The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation.
DNA repair 2004;3(8-9):1117-22.
2004: Quynh-Thu Le; Nicholas C Denko; Amato J Giaccia
Hypoxic gene expression and metastasis.
Cancer metastasis reviews 2004;23(3-4):293-310.
2004: Scott G Soltys; Quynh-Thu Le; Gongyi Shi; Robert Tibshirani; Amato J Giaccia; Albert C Koong
The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(14):4806-12.
2004: Cornelia Leo; Amato J Giaccia; Nicholas C Denko
The hypoxic tumor microenvironment and gene expression.
Seminars in radiation oncology 2004;14(3):207-14.
2004: Ali Salim; Amato J Giaccia; Michael T Longaker
Stem cell differentiation.
Nature biotechnology 2004;22(7):804-5; author reply 805-6.
2004: David Pfander; Tatsuya Kobayashi; Melissa C Knight; Elazar Zelzer; Denise A Chan; Bjorn R Olsen; Amato J Giaccia; Randall S Johnson; Volker H Haase; Ernestina Schipani
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.
Development (Cambridge, England) 2004;131(10):2497-508.
2004: Bennett Kaufman; Orit Scharf; Jeffrey Arbeit; Margaret Ashcroft; J Martin Brown; Richard K Bruick; J Donald Chapman; Sydney M Evans; Amato J Giaccia; Adrian L Harris; Eric Huang; Randall Johnson; William Kaelin; Cameron J Koch; Patrick Maxwell; James Mitchell; Len Neckers; Garth Powis; Joseph Rajendran; Gregg L Semenza; Jonathan Simons; Erik Storkebaum; Michael J Welch; Murray Whitelaw; Giovanni Melillo; S Percy Ivy
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Cancer research 2004;64(9):3350-6.
2004: Lynne Bemis; Denise A Chan; Carla V Finkielstein; Lin Qi; Patrick D Sutphin; Xiaojiang S Chen; Kurt R Stenmark; Amato J Giaccia; Wayne Zundel
Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.
Genes & development 2004;18(7):739-44.
2004: Barbara Bedogni; Melony S O'Neill; Scott M Welford; Donna M Bouley; Amato J Giaccia; Nicholas C Denko; Marianne Powell
Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice.
Cancer research 2004;64(7):2552-60.
2004: Patrick D Sutphin; Denise A Chan; Amato J Giaccia
Dead cells don't form tumors: HIF-dependent cytotoxins.
Cell cycle (Georgetown, Tex.) 2004;3(2):160-3.
2004: Lillian Marie Swiersz; Amato J Giaccia; Zhong Yun
Oxygen-dependent regulation of adipogenesis.
Methods in enzymology 2004;381():387-95.
2003: Ester M Hammond; Susannah L Green; Amato J Giaccia
Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest.
Mutation research 2003;532(1-2):205-13.
2003: Quynh-Thu Le; Amato J Giaccia
Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(12):4287-95.
2003: Amato J Giaccia; Bronwyn G Siim; Randall S Johnson
HIF-1 as a target for drug development.
Nature reviews. Drug discovery 2003;2(10):803-11.
2003: Nicholas C Denko; Lucrezia A Fontana; Karen M Hudson; Patrick D Sutphin; Soumya Raychaudhuri; Russ Altman; Amato J Giaccia
Investigating hypoxic tumor physiology through gene expression patterns.
Oncogene 2003;22(37):5907-14.
2003: Quynh-Thu Le; Amato J Giaccia
HIF-alpha, a gender independent transcription factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2391-3.
2003: Sang-Ki Park; Agnes Dadak; Volker H Haase; Lucrezia Fontana; Amato J Giaccia; Randall S Johnson
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.
Molecular and cellular biology 2003;23(14):4959-71.
2003: Ester M Hammond; Mary Jo Dorie; Amato J Giaccia
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation.
The Journal of biological chemistry 2003;278(14):12207-13.
2003: Zhong Yun; Amato J Giaccia
Tumor deprivation of oxygen and tumor suppressor gene function.
Methods in molecular biology (Clifton, N.J.) 2003;223():485-504.
2003: Quynh-Thu Le; Patrick D Sutphin; Soumya Raychaudhuri; Sheue Ching T Yu; David J Terris; Ho-Sheng Lin; Bert Lum; Harlan A Pinto; Albert C Koong; Amato J Giaccia
Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):59-67.
2002: Denise A Chan; Patrick D Sutphin; Nicholas C Denko; Amato J Giaccia
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
The Journal of biological chemistry 2002;277(42):40112-7.
2002: Christine C Hudson; Mei Liu; Gary G Chiang; Diane M Otterness; Dawn C Loomis; Fiona Kaper; Amato J Giaccia; Robert T Abraham
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.
Molecular and cellular biology 2002;22(20):7004-14.
2002: Heather L Maecker; Zhong Yun; Holden T Maecker; Amato J Giaccia
Epigenetic changes in tumor Fas levels determine immune escape and response to therapy.
Cancer cell 2002;2(2):139-48.
2002: Ester M Hammond; Amato J Giaccia
Antiangiogenic therapy and p53.
Science (New York, N.Y.) 2002;297(5581):471; discussion 471.
2002: Maria Lluria-Prevatt; Jeanne Morreale; Jacie Gregus; David S Alberts; Fiona Kaper; Amato J Giaccia; Marianne Powell
Effects of perillyl alcohol on melanoma in the TPras mouse model.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002;11(6):573-9.
2002: Zhong Yun; Heather L Maecker; Randall S Johnson; Amato J Giaccia
Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia.
Developmental cell 2002;2(3):331-41.
2002: Ester M Hammond; Nicholas C Denko; Mary Jo Dorie; Robert T Abraham; Amato J Giaccia
Hypoxia links ATR and p53 through replication arrest.
Molecular and cellular biology 2002;22(6):1834-43.
2002: S C Liu; N P Minton; Amato J Giaccia; J Martin Brown
Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis.
Gene therapy 2002;9(4):291-6.
2002: Toru Shibata; Amato J Giaccia; J Martin Brown
Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy.
Neoplasia (New York, N.Y.) 2002;4(1):40-8.
2001: RM Popovici; M Lu; S Bhatia; Gerry H Faessen; Amato J Giaccia; Linda C Giudice
Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency.
The Journal of clinical endocrinology and metabolism 2001;86(6):2653-9.
2001: Eunice Y Chen; NM Mazure; J A Cooper; Amato J Giaccia
Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation.
Cancer research 2001;61(6):2429-33.
2001: Nicholas C Denko; Amato J Giaccia
Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis.
Cancer research 2001;61(3):795-8.
2001: Constantinos Koumenis; RM Alarcon; Ester Hammond; Patrick D Sutphin; W Hoffman; M Murphy; J Derr; Yoichi Taya; Scott W Lowe; M Kastan; Amato J Giaccia
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.
Molecular and cellular biology 2001;21(4):1297-310.
2001: Sherril L Green; Rachel A Freiberg; Amato J Giaccia
p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest.
Molecular and cellular biology 2001;21(4):1196-206.
2001: RM Alarcon; Nicholas C Denko; Amato J Giaccia
Genetic determinants that influence hypoxia-induced apoptosis.
Novartis Foundation symposium 2001;240():115-28; discussion 128-32.
2000: J Sugawara; Salli I Tazuke; LF Suen; D R Powell; Fiona Kaper; Amato J Giaccia; Linda C Giudice
Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3',5'-cyclic adenosine monophosphate is additive in HepG2 cells.
The Journal of clinical endocrinology and metabolism 2000;85(10):3821-7.
2000: Heather L Maecker; Constantinos Koumenis; Amato J Giaccia
p53 promotes selection for Fas-mediated apoptotic resistance.
Cancer research 2000;60(16):4638-44.
2000: J Sugawara; D S Suh; Gerry H Faessen; LF Suen; T Shibata; Fiona Kaper; Amato J Giaccia; Linda C Giudice
Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions.
The Journal of clinical endocrinology and metabolism 2000;85(8):2714-21.
2000: Nicholas C Denko; Sherril L Green; D Edwards; Amato J Giaccia
p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia.
Experimental cell research 2000;258(1):82-91.
2000: Keith R Laderoute; RM Alarcon; M D Brody; Joy M Calaoagan; E Y Chen; A Merrill Knapp; Z Yun; Nicholas C Denko; Amato J Giaccia
Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2941-50.
2000: T Shibata; Amato J Giaccia; J Martin Brown
Development of a hypoxia-responsive vector for tumor-specific gene therapy.
Gene therapy 2000;7(6):493-8.
2000: Wayne Zundel; Lillian Marie Swiersz; Amato J Giaccia
Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide.
Molecular and cellular biology 2000;20(5):1507-14.
2000: Albert C Koong; Nicholas C Denko; K M Hudson; Cornelia Leo; Lillian Marie Swiersz; C Koch; S Evans; H Ibrahim; Quynh-Thu Le; David J Terris; Amato J Giaccia
Candidate genes for the hypoxic tumor phenotype.
Cancer research 2000;60(4):883-7.
2000: Wayne Zundel; Cornelia Leo; Daphne A Haas-Kogan; Albert C Koong; Fiona Kaper; E Chen; A R Gottschalk; H E Ryan; Randall S Johnson; A B Jefferson; David Stokoe; Amato J Giaccia
Loss of PTEN facilitates HIF-1-mediated gene expression.
Genes & development 2000;14(4):391-6.
2000: Nicholas C Denko; Cornelia Leo; Albert C Koong; Keith R Laderoute; C Green; Amato J Giaccia
Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):480-7.
1999: R Alarcón; Constantinos Koumenis; Rory Geyer; Carl G Maki; Amato J Giaccia
Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation.
Cancer research 1999;59(24):6046-51.
1999: Bradly G Wouters; Nicholas C Denko; Amato J Giaccia; J M Brown
A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy.
Oncogene 1999;18(47):6540-5.
1999: RM Popovici; JC Irwin; Amato J Giaccia; Linda C Giudice
Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration.
The Journal of clinical endocrinology and metabolism 1999;84(6):2245-8.
1999: Keith R Laderoute; Holly L Mendonca; Joy M Calaoagan; A Merrill Knapp; Amato J Giaccia; Philip J S Stork
Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity.
The Journal of biological chemistry 1999;274(18):12890-7.
1999: Brian J Murphy; Glen K Andrews; Doug Bittel; D J Discher; J McCue; C J Green; M Yanovsky; Amato J Giaccia; R M Sutherland; Keith R Laderoute; Keith A Webster
Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.
Cancer research 1999;59(6):1315-22.
1998: A Spicher; OM Guicherit; L Duret; Aaron S. Aslanian; E M Sanjines; Nicholas C Denko; Amato J Giaccia; Helen M Blau
Highly conserved RNA sequences that are sensors of environmental stress.
Molecular and cellular biology 1998;18(12):7371-82.
1998: Amato J Giaccia; M B Kastan
The complexity of p53 modulation: emerging patterns from divergent signals.
Genes & development 1998;12(19):2973-83.
1998: Salli I Tazuke; NM Mazure; J Sugawara; G Carland; Gerry H Faessen; LF Suen; JC Irwin; D R Powell; Amato J Giaccia; Linda C Giudice
Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10188-93.
1998: Sherril L Green; Amato J Giaccia
Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy.
The cancer journal from Scientific American 1998;4(4):218-23.
1998: Wayne Zundel; Amato J Giaccia
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress.
Genes & development 1998;12(13):1941-6.
1998: J E Lee; C Y Kim; Amato J Giaccia; Rona G Giffard
The E6 and E7 genes of human papilloma virus-type 16 protect primary astrocyte cultures from injury.
Brain research 1998;795(1-2):10-6.
1998: BA Rupnow; AD Murtha; RM Alarcon; Amato J Giaccia; Susan J Knox
Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy.
Cancer research 1998;58(9):1779-84.
1998: J Martin Brown; Amato J Giaccia
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
Cancer research 1998;58(7):1408-16.
1998: BA Rupnow; RM Alarcon; Amato J Giaccia; Susan J Knox
p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts.
Cell death and differentiation 1998;5(2):141-7.
1997: Constantinos Koumenis; Amato J Giaccia
Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis.
Molecular and cellular biology 1997;17(12):7306-16.
1997: Bradly G Wouters; Amato J Giaccia; Nicholas C Denko; J Martin Brown
Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism.
Cancer research 1997;57(21):4703-6.
1997: NM Mazure; Eunice Y Chen; Keith R Laderoute; Amato J Giaccia
Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element.
Blood 1997;90(9):3322-31.
1997: C Y Kim; M H Tsai; C Osmanian; T G Graeber; J E Lee; Rona G Giffard; J A DiPaolo; Donna M Peehl; Amato J Giaccia
Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions.
Cancer research 1997;57(19):4200-4.
1997: M J Lemmon; P van Zijl; M E Fox; M L Mauchline; Amato J Giaccia; N P Minton; J Martin Brown
Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment.
Gene therapy 1997;4(8):791-6.
1996: L M Fried; Constantinos Koumenis; SR Peterson; Sherril L Green; P van Zijl; J Allalunis-Turner; David J Chen; R Fishel; Amato J Giaccia; J Martin Brown; C U Kirchgessner
The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13825-30.
1996: RM Alarcon; BA Rupnow; T G Graeber; Susan J Knox; Amato J Giaccia
Modulation of c-Myc activity and apoptosis in vivo.
Cancer research 1996;56(19):4315-9.
1996: N M Mazure; E Y Chen; P Yeh; Keith R Laderoute; Amato J Giaccia
Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.
Cancer research 1996;56(15):3436-40.
1996: M E Fox; M J Lemmon; M L Mauchline; T O Davis; Amato J Giaccia; Nigel P Minton; J M Brown
Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia.
Gene therapy 1996;3(2):173-8.
1996: M Bergeron; Nahid F Mivechi; Amato J Giaccia; Rona G Giffard
Mechanism of heat shock protein 72 induction in primary cultured astrocytes after oxygen-glucose deprivation.
Neurological research 1996;18(1):64-72.
1996: T G Graeber; C Osmanian; T Jacks; D E Housman; C J Koch; Scott W Lowe; Amato J Giaccia
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours.
Nature 1996;379(6560):88-91.
1995: Nahid F Mivechi; Amato J Giaccia
Mitogen-activated protein kinase acts as a negative regulator of the heat shock response in NIH3T3 cells.
Cancer research 1995;55(23):5512-9.
1995: Nigel P Minton; M L Mauchline; M J Lemmon; J K Brehm; M Fox; N P Michael; Amato J Giaccia; J M Brown
Chemotherapeutic tumour targeting using clostridial spores.
FEMS microbiology reviews 1995;17(3):357-64.
1995: T Girinsky; Constantinos Koumenis; T G Graeber; Donna M Peehl; Amato J Giaccia
Attenuated response of p53 and p21 in primary cultures of human prostatic epithelial cells exposed to DNA-damaging agents.
Cancer research 1995;55(17):3726-31.
1994: A C Koong; E Y Chen; Nahid F Mivechi; Nicholas C Denko; Peter J Stambrook; Amato J Giaccia
Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).
Cancer research 1994;54(20):5273-9.
1994: A H Saad; S S Kuo; A C Koong; G M Hahn; Amato J Giaccia
Modulation of potassium channels by protein tyrosine kinase inhibitors.
Journal of cellular physiology 1994;161(1):142-8.
1994: T G Graeber; J F Peterson; M Tsai; K Monica; A J Fornace; Amato J Giaccia
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.
Molecular and cellular biology 1994;14(9):6264-77.
1994: Nicholas C Denko; Amato J Giaccia; J R Stringer; Peter J Stambrook
The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5124-8.
1994: A C Koong; E Y Chen; C Y Kim; Amato J Giaccia
Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells.
International journal of radiation oncology, biology, physics 1994;29(2):259-65.
1994: Nahid F Mivechi; A C Koong; Amato J Giaccia; G M Hahn
Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1994;10(3):371-9.
1994: A C Koong; E A Auger; E Y Chen; Amato J Giaccia
The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors.
Radiation research 1994;138(1 Suppl):S60-3.
1994: A C Koong; E Y Chen; Amato J Giaccia
Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.
Cancer research 1994;54(6):1425-30.
1994: A C Koong; E Y Chen; A S Lee; J Martin Brown; Amato J Giaccia
Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction.
International journal of radiation oncology, biology, physics 1994;28(3):661-6.
1993: L Alvarez; James W Evans; R Wilks; J N Lucas; J Martin Brown; Amato J Giaccia
Chromosomal radiosensitivity at intrachromosomal telomeric sites.
Genes, chromosomes & cancer 1993;8(1):8-14.
1993: A C Koong; Amato J Giaccia; G M Hahn; A H Saad
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
Journal of cellular physiology 1993;156(2):341-7.
1993: E A Auger; Amato J Giaccia; G M Hahn
Heat sensitivity of bleomycin-sensitive CHO derivatives is not due to improper initialization of heat shock response.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1993;9(2):275-84.
1993: S S Kuo; A H Saad; A C Koong; G M Hahn; Amato J Giaccia
Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):908-12.
1992: Amato J Giaccia; J Schwartz; J Shieh; J Martin Brown
The use of asymmetric-field inversion gel electrophoresis to predict tumor cell radiosensitivity.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1992;24(4):231-8.
1992: Amato J Giaccia; E A Auger; A Koong; David J Terris; A I Minchinton; G M Hahn; J Martin Brown
Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro.
International journal of radiation oncology, biology, physics 1992;23(4):891-7.
1992: A Cholon; Amato J Giaccia; A D Lewis; I Hickson; J Martin Brown
What role do glutathione S-transferases play in the cellular response to ionizing radiation?
International journal of radiation oncology, biology, physics 1992;22(4):759-63.
1992: Amato J Giaccia; K A Biedermann; L M Tosto; A I Minchinton; Mary S Kovacs; J Martin Brown
Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233.
International journal of radiation oncology, biology, physics 1992;22(4):681-4.
1991: Amato J Giaccia; A D Lewis; Nicholas C Denko; A Cholon; James W Evans; Charles A Waldren; Thomas D Stamato; J Martin Brown
The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity.
Cancer research 1991;51(16):4463-9.
1991: Amato J Giaccia; J Shieh; A Cholon; J Martin Brown
Biochemical evidence for two different mechanisms for bleomycin-induced cell killing.
Mutation research 1991;263(2):69-75.
1991: R L Anderson; K J Fong; T Gabriele; P Lavagnini; G M Hahn; James W Evans; Charles A Waldren; Thomas D Stamato; Amato J Giaccia
Loss of the intrinsic heat resistance of human cells and changes in Mr 70,000 heat shock protein expression in human x hamster hybrids.
Cancer research 1991;51(10):2636-41.
1991: K A Biedermann; J R Sun; Amato J Giaccia; L M Tosto; J Martin Brown
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1394-7.
1990: Amato J Giaccia; James W Evans; J Martin Brown
Use of fluorescent in situ hybridization to detect chromosomal rearrangements in somatic cell hybrids.
Genes, chromosomes & cancer 1990;2(3):248-51.
1990: Amato J Giaccia; Nicholas C Denko; R MacLaren; D Mirman; Charles A Waldren; I Hart; Thomas D Stamato
Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.
American journal of human genetics 1990;47(3):459-69.
1990: I B Bahari; Joel S Bedford; Amato J Giaccia; Thomas D Stamato
Measurement of the relative proportion of symmetrical and asymmetrical chromosome-type interchanges induced by gamma radiation in human-hamster hybrid cells.
Radiation research 1990;123(1):105-7.
1990: Amato J Giaccia; R A MacLaren; Nicholas C Denko; D Nicolaou; Thomas D Stamato
Increased sensitivity to killing by restriction enzymes in the XR-1 DNA double-strand break repair-deficient mutant.
Mutation research 1990;236(1):67-76.
1990: P Hentosh; Andrew Collins; L Correll; A J Fornace; Amato J Giaccia; Charles A Waldren
Genetic and biochemical characterization of the CHO-UV-1 mutant defective in postreplication recovery of DNA.
Cancer research 1990;50(8):2356-62.
1989: P Dasgupta; A J Linnenbach; Amato J Giaccia; Thomas D Stamato; E Premkumar Reddy
Molecular cloning of the breakpoint region on chromosome 6 in cutaneous malignant melanoma: evidence for deletion in the c-myb locus and translocation of a segment of chromosome 12.
Oncogene 1989;4(10):1201-5.
1989: Thomas D Stamato; E Richardson; J Ianacone; R A MacLaren; Nicholas C Denko; Amato J Giaccia
Isolation and characterization of glucose-6-phosphate dehydrogenase-deficient Chinese hamster cells derived from pure mutant colonies.
Mutagenesis 1989;4(4):259-64.
1989: Nicholas C Denko; Amato J Giaccia; B Peters; Thomas D Stamato
An asymmetric field inversion gel electrophoresis method for the separation of large DNA molecules.
Analytical biochemistry 1989;178(1):172-6.
1989: Amato J Giaccia; E Richardson; Nicholas C Denko; Thomas D Stamato
Genetic analysis of XR-1 mutation in hamster and human hybrids.
Somatic cell and molecular genetics 1989;15(1):71-7.
1988: Thomas D Stamato; A Dipatri; Amato J Giaccia
Cell-cycle-dependent repair of potentially lethal damage in the XR-1 gamma-ray-sensitive Chinese hamster ovary cell.
Radiation research 1988;115(2):325-33.
1987: Thomas D Stamato; B Peters; P Patil; Nicholas C Denko; R Weinstein; Amato J Giaccia
Isolation and characterization of bleomycin-sensitive Chinese hamster ovary cells.
Cancer research 1987;47(6):1588-92.
1985: Amato J Giaccia; R Weinstein; J Hu; Thomas D Stamato
Cell cycle-dependent repair of double-strand DNA breaks in a gamma-ray-sensitive Chinese hamster cell.
Somatic cell and molecular genetics 1985;11(5):485-91.
1984: Thomas D Stamato; R Weinstein; Amato J Giaccia
Timing of mutation-fixation events in ethyl methane sulfonate-treated Chinese hamster cells.
Somatic cell and molecular genetics 1984;10(4):429-34.