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Giuseppe Giaccone

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Lesley K Seymour; Marinus W Lobbezoo; A Hilary Calvert; Elizabeth A Eisenhauer; Giuseppe Giaccone
Design and conduct of early clinical studies of two or more targeted anticancer therapies: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies.
Kazuto Furuyama; Giuseppe Giaccone; Taishi Harada; Kayo Ijichi; Eiji Iwama; Heyan Li; Kyoko Okamura; Keiichi Ota; Yoshimasa Shiraishi; Koichi Takayama; Shuo Wang; Akiko Fujii; Yoichi Nakanishi
Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors.
Iacopo Petrini; Trung Pham; Donna Voeller; Yisong Wang; Paolo Andrea Zucali; Hye Seung Lee; Paul S Meltzer; Giuseppe Giaccone
Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors.

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2013: Lesley K Seymour; Marinus W Lobbezoo; A Hilary Calvert; Elizabeth A Eisenhauer; Giuseppe Giaccone
Design and conduct of early clinical studies of two or more targeted anticancer therapies: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies.
European journal of cancer (Oxford, England : 1990) 2013;49(8):1808-14.
2013: Kazuto Furuyama; Giuseppe Giaccone; Taishi Harada; Kayo Ijichi; Eiji Iwama; Heyan Li; Kyoko Okamura; Keiichi Ota; Yoshimasa Shiraishi; Koichi Takayama; Shuo Wang; Akiko Fujii; Yoichi Nakanishi
Sensitivity and kinase activity of epidermal growth factor receptor (EGFR) exon 19 and others to EGFR-tyrosine kinase inhibitors.
Cancer science 2013;104(5):584-9.
2013: Iacopo Petrini; Trung Pham; Donna Voeller; Yisong Wang; Paolo Andrea Zucali; Hye Seung Lee; Paul S Meltzer; Giuseppe Giaccone
Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(8):1960-71.
2013: Marcello Tiseo; Arun Rajan; Anish Thomas; Giuseppe Giaccone
"Pseudocavitation" in thymic carcinoma during treatment with sunitinib.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(4):511-2.
2013: Anish Thomas; David Venzon; Arlene W Berman; Peter Choyke; Sean Khozin; Karen A Kurdziel; Esther Mena; Arun Rajan; Eva Szabo; Giuseppe Giaccone
18F-fluorodeoxyglucose positron emission tomography in the management of patients with thymic epithelial tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(6):1487-93.
2013: A Thomas; Y Wang; A Lopez-Chavez; A Rajan; Giuseppe Giaccone
From targets to targeted therapies and molecular profiling in non-small cell lung carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2013;24(3):577-85.
2013: Anish Thomas; Andrew Arai; Arlene Berman; Karl Haglund; Marko Jakopovic; King F Kwong; Arun Rajan; David S Schrump; Sujata Shanbhag; Eva Szabo; Giuseppe Giaccone
Characterization and management of cardiac involvement of thymic epithelial tumors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(2):246-9.
2013: Christina Brzezniak; Corey A Carter; Giuseppe Giaccone
Dacomitinib, a new therapy for the treatment of non-small cell lung cancer.
Expert opinion on pharmacotherapy 2013;14(2):247-53.
2013: Iacopo Petrini; Trung Pham; Arun Rajan; Donna Voeller; Yisong Wang; Sean Davis; James Gao; Giuseppe Giaccone
Whole genome and transcriptome sequencing of a b3 thymoma.
PloS one 2013;8(4):e60572.
2013: Johannes Voortman; Y Wang; R P Chang; T Harada; J Keith Killian; M Lucchi; Paul S Meltzer; William Smith; Miia Suuriniemi; Giuseppe Giaccone
Detection and therapeutic implications of c-Met mutations in small cell lung cancer and neuroendocrine tumors.
Current pharmaceutical design 2013;19(5):833-40.
2012: Meng-Tzu Weng; Poonam Mannan; Aaron J Schetter; Sina Shahamatdar; Jin-Chuan Sheu; Stephen Swatkoski; Shu-Chen Wei; Christina M Annunziata; Chad J Creighton; Michael J Emanuele; Susan Garfield; Giuseppe Giaccone; Marjan Gucek; Curtis C Harris; Dennis Hsu; Marianne K H Kim; Jih-Hsiang Lee; Qiuning Li; Ji Luo
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(52):E3659-67.
2012: Sean Khozin; Arun Rajan; Mark J Roth; Karen Smith; Anish Thomas; Arlene Berman; Giuseppe Giaccone
Hepatoid carcinoma of the lung with anaplastic lymphoma kinase gene rearrangement.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(11):e29-31.
2012: Takefumi Komiya; Arun Rajan; Anish Thomas; Yisong Wang; Sean Khozin; Giuseppe Giaccone
Response to crizotinib in ROS1-rearranged non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(27):3425-6; author reply 3426.
2012: Paola Tucci; Peter Vandenabeele; Karen H Vousden; Patricia A J Muller; Berna S Sayan; Nozomi Takahashi; Alessandro Terrinoni; Massimiliano Agostini; Volker Dötsch; Giuseppe Giaccone; Francesca Grespi; Sebastian Kehrloesser; Richard A Knight; Arnold J Levine; Scott W Lowe; Elke K Markert; Gerry Melino
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15312-7.
2012: Ronan J Kelly; Corey A Carter; Giuseppe Giaccone
HER2 mutations in non-small-cell lung cancer can be continually targeted.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(26):3318-9.
2012: Nicola M Neary; Nicholas Schaub; Constantine A Stratakis; Brent S Abel; Alison M Boyce; Giuseppe Giaccone; King Kwong; Ariel Lopez-Chavez; Cesar A Moran; Lynnette K Nieman
Neuroendocrine ACTH-producing tumor of the thymus--experience with 12 patients over 25 years.
The Journal of clinical endocrinology and metabolism 2012;97(7):2223-30.
2012: Anish Thomas; Arun Rajan; Giuseppe Giaccone
Tyrosine kinase inhibitors in lung cancer.
Hematology/oncology clinics of North America 2012;26(3):589-605, viii.
2012: Charles Rudin; Geoffrey I Shapiro; Philip D Bonomi; Todd A Busman; D Ross Camidge; Arunava Chakravartty; Quincy Chu; Brenda J Chyla; Caroline Dive; Barry L Dowell; Edward B Garon; Giuseppe Giaccone; CHRISTINE HANN; Rod A Humerickhouse; Divis Khaira; Andrew Krivoshik; M Mabry; Evelyn M McKeegan; Cathy E Nolan; Suresh S Ramalingam; Malcolm R Ranson; Moacyr Ribeiro de Oliveira; Niki Rudersdorf; Leena Gandhi
Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(11):3163-9.
2012: Arun Rajan; Shawn Spencer; Eva Szabo; Sukyung Woo; Mary Ann Yancey; Martin Gutierrez; Jiuping Ji; Ronan J Kelly; Shivaani Kummar; Baskar Mannargudi; Corey A Carter; William Douglas Figg; Giuseppe Giaccone
A phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(8):2344-51.
2012: Petrini Petrini; Arun Rajan; Yisong Wang; Jianwu Xie; Paolo A Zucali; Michael J Cameron; Christopher A French; Elaine S Jaffe; Giuseppe Giaccone
NUT rearrangement is uncommon in human thymic epithelial tumors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(4):744-50.
2012: Cody J Peer; Emily D Richardson; Tristan Sissung; Sarah M Troutman; David Venzon; BRIGITTE WIDEMANN; Sukyung Woo; Robert Yarchoan; William Dahut; Bevin C English; Joel Federspiel; Erin R Gardner; Giuseppe Giaccone; Lokesh Jain; Aerang Kim; C Tyler Kirkland; Elise Kohn; Shivaani Kummar; William D Figg
Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9: implications of genetic variants on pharmacokinetics and hyperbilirubinemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(7):2099-107.
2012: Sinchita Roy Chowdhuri; Michael R Emmert-Buck; Arlene Berman; Giuseppe Giaccone; Jeffrey Hanson; Trinh Hoc-Tran Pham; Mark Raffeld; Arun Rajan; Jaime Rodriguez-Canales; Liqiang Xi; Armando C Filie
EGFR and KRAS mutation analysis in cytologic samples of lung adenocarcinoma enabled by laser capture microdissection.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012;25(4):548-55.
2012: Corey A Carter; Giuseppe Giaccone
Treatment of nonsmall cell lung cancer: overcoming the resistance to epidermal growth factor receptor inhibitors.
Current opinion in oncology 2012;24(2):123-9.
2012: Jih-Hsiang Lee; Paul S Meltzer; Iacopo Petrini; Seth M Steinberg; Johannes Voortman; Qiuyan Wang; Yisong Wang; Yonghong Wang; Nicola Funel; Elisa Giovannetti; Jin-Hyeok Hwang; Giuseppe Giaccone
Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(2):524-33.
2012: Sinchita Roy Chowdhuri; Jaime Rodriguez-Canales; Ulysses J Balis; Jerome Cheng; Michael R Emmert-Buck; Patricia A Fetsch; Armando C Filie; Giuseppe Giaccone; Jeffrey Hanson; Jason D Hipp
Semiautomated laser capture microdissection of lung adenocarcinoma cytology samples.
Acta cytologica 2012;56(6):622-31.
2012: Christopher G Azzoli; Sarah Temin; Giuseppe Giaccone
2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer.
Journal of oncology practice / American Society of Clinical Oncology 2012;8(1):63-6.
2011: Arun Rajan; Michael Shnaidman; Jane B Trepel; Wadih M Zein; Sylvia V Alarcon; Nicoletta Brega; Sonja Crandon; William D Figg; Martin Gutierrez; Brett E Houk; Lokesh Jain; Ronan J Kelly; Yeong Sang Kim; Shivaani Kummar; Baskar Mannargudi; Giuseppe Giaccone
A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(21):6831-9.
2011: Christopher G Azzoli; Sherman Baker; Julie R Brahmer; Giuseppe Giaccone; David H Johnson; Janessa L Laskin; Gregory Masters; Daniel Milton; Luke Nordquist; William Pao; David G Pfister; Steven Piantadosi; Joan H Schiller; Reily Smith; Thomas J Smith; John R Strawn; Sarah Temin; David Trent; Timothy B Aliff
2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(28):3825-31.
2011: Giuseppe Giaccone; Yisong Wang
Strategies for overcoming resistance to EGFR family tyrosine kinase inhibitors.
Cancer treatment reviews 2011;37(6):456-64.
2011: Victoria L Luchenko; Robert F Murphy; Yves Pommier; Crystal D Salcido; Keli Agama; Susan E Bates; Giuseppe Giaccone; Edina Komlodi-Pasztor; Yongwei Zhang; Lyuba Varticovski
Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancer.
Cell cycle (Georgetown, Tex.) 2011;10(18):3119-28.
2011: Ronan J Kelly; Giuseppe Giaccone
Lung cancer vaccines.
Cancer journal (Sudbury, Mass.) 2011;17(5):302-8.
2011: Hester van Cruijsen; Karin Weijers; Cynthia Fehres; Giuseppe Giaccone; Klaas Hoekman; Jelle J Lindenberg; Sinéad M Lougheed; Dinja Oosterhoff; Rik J Scheper; Robert van Boerdonk; Tanja D de Gruijl
Glioblastoma-induced inhibition of Langerhans cell differentiation from CD34(+) precursors is mediated by IL-6 but unaffected by JAK2/STAT3 inhibition.
Immunotherapy 2011;3(9):1051-61.
2011: Lokesh Jain; Elise C Kohn; Shivaani Kummar; Diane R Mould; Jürgen Venitz; Sukyung Woo; Robert Yarchoan; William L Dahut; Erin R Gardner; Giuseppe Giaccone; William D Figg
Population pharmacokinetic analysis of sorafenib in patients with solid tumours.
British journal of clinical pharmacology 2011;72(2):294-305.
2011: Jeremy Force; Arun Rajan; Seth M Steinberg; Eva Dombi; Giuseppe Giaccone
Assessment of objective responses using volumetric evaluation in advanced thymic malignancies and metastatic non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(7):1267-73.
2011: Shahinaz Gadalla; Arun Rajan; Ruth Pfeiffer; Sigurdur Y Kristinsson; Magnus Björkholm; Ola Landgren; Giuseppe Giaccone
A population-based assessment of mortality and morbidity patterns among patients with thymoma.
International journal of cancer. Journal international du cancer 2011;128(11):2688-94.
2011: Giuseppe Giaccone; Arun Rajan; Arlene Berman; Ronan J Kelly; Eva Szabo; Ariel Lopez-Chavez; Jane Trepel; Min-Jung Lee; Liang Cao; Igor Espinoza-Delgado; John Spittler; Patrick J Loehrer
Phase II study of belinostat in patients with recurrent or refractory advanced thymic epithelial tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(15):2052-9.
2011: Vicki Leigh Keedy; Sarah Temin; Mark R Somerfield; Mary Beth Beasley; David H Johnson; Lisa M McShane; Daniel T Milton; John R Strawn; Heather A Wakelee; Giuseppe Giaccone
American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(15):2121-7.
2011: Taishi Harada; Yasushi Yatabe; Masafumi Takeshita; Takaomi Koga; Tokujiro Yano; Yisong Wang; Giuseppe Giaccone
Role and relevance of TrkB mutations and expression in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(9):2638-45.
2011: Marco Breinig; Philipp Mayer; Andreas Harjung; Benjamin Goeppert; Mona Malz; Roland Penzel; Olaf Neumann; Arndt Hartmann; Hendrik Dienemann; Giuseppe Giaccone; Peter Schirmacher; Michael André Kern; Gabriela Chiosis; Ralf Joachim Rieker
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2237-49.
2011: T Harada; A Lopez-Chavez; L Xi; Mark Raffeld; Y Wang; Giuseppe Giaccone
Characterization of epidermal growth factor receptor mutations in non-small-cell lung cancer patients of African-American ancestry.
Oncogene 2011;30(15):1744-52.
2011: Ronan J Kelly; Arun Rajan; Jeremy Force; Ariel Lopez-Chavez; Corrine Keen; Liang Cao; Yunkai Yu; Peter Choyke; Baris Turkbey; Mark Raffeld; Liqiang Xi; Seth M Steinberg; John J Wright; Shivaani Kummar; Martin Gutierrez; Giuseppe Giaccone
Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(5):1190-9.
2011: Clara Lemos; Elisa Giovannetti; Paolo A Zucali; Yehuda G Assaraf; George L Scheffer; Tahar van der Straaten; Armida D'Incecco; Alfredo Falcone; Henk-Jan Guchelaar; Romano Danesi; Armando Santoro; Giuseppe Giaccone; Carmelo Tibaldi; Godefridus J Peters
Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients.
Pharmacogenomics 2011;12(2):159-70.
2011: Arun Rajan; Giuseppe Giaccone
Chemotherapy for thymic tumors: induction, consolidation, palliation.
Thoracic surgery clinics 2011;21(1):107-14, viii.
2011: Yisong Wang; Giuseppe Giaccone
Challenges in cancer molecular targets and therapeutics.
Frontiers in oncology 2011;1():4.
2011: Giuseppe Giaccone
Grand challenges in oncology.
Frontiers in oncology 2011;1():26.
2011: Jih-Hsiang Lee; Trung Pham; Donna M Voeller; Johannes Voortman; Yisong Wang; Anne-Marie C Dingemans; Giuseppe Giaccone
MicroRNA expression and clinical outcome of small cell lung cancer.
PloS one 2011;6(6):e21300.
2010: Peter D Burbelo; Sarah K Browne; Elizabeth P Sampaio; Giuseppe Giaccone; Rifat Zaman; Ervand Kristosturyan; Arun Rajan; Li Ding; Kathryn H Ching; Arlene Berman; Joao B Oliveira; Amy P Hsu; Caitlin M Klimavicz; Michael J Iadarola; Steven M Holland
Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia.
Blood 2010;116(23):4848-58.
2010: Yisong Wang; Jane B Trepel; Leonard M Neckers; Giuseppe Giaccone
STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer.
Current opinion in investigational drugs (London, England : 2000) 2010;11(12):1466-76.
2010: Lokesh Jain; Erin R Gardner; Jürgen Venitz; Giuseppe Giaccone; Brett E Houk; William D Figg
Determination of PF-04928473 in human plasma using liquid chromatography with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(30):3187-92.
2010: Johannes Voortman; Akiteru Goto; Jean Mendiboure; Jane J Sohn; Aaron J Schetter; Motonobu Saito; Ariane Dunant; Trung C Pham; Iacopo Petrini; Alan Lee; Mohammed A Khan; Pierre Hainaut; Jean-Pierre Pignon; Elisabeth Brambilla; Helmut H Popper; Martin Filipits; Curtis C Harris; Giuseppe Giaccone
MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma.
Cancer research 2010;70(21):8288-98.
2010: J Keith Killian; Robert L Walker; Miia Suuriniemi; Laura Jones; Stephanie Scurci; Parvati Singh; Robert Cornelison; Shannon Harmon; Nichole Boisvert; Jack Zhu; Yonghong Wang; Sven Bilke; Sean Davis; Giuseppe Giaccone; William I Smith; Paul S Meltzer
Archival fine-needle aspiration cytopathology (FNAC) samples: untapped resource for clinical molecular profiling.
The Journal of molecular diagnostics : JMD 2010;12(6):739-45.
2010: Paolo Andrea Zucali; Iacopo Petrini; Elena Lorenzi; Maria Merino; Liang Cao; Luca Di Tommaso; Hye Seung Lee; Matteo Incarbone; Beatriz A Walter; Matteo Simonelli; Massimo Roncalli; Armando Santoro; Giuseppe Giaccone
Insulin-like growth factor-1 receptor and phosphorylated AKT-serine 473 expression in 132 resected thymomas and thymic carcinomas.
Cancer 2010;116(20):4686-95.
2010: Arun Rajan; Giuseppe Giaccone
Targeted therapy for advanced thymic tumors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(10 Suppl 4):S361-4.
2010: Giuseppe Giaccone
Epithelial tumors of the thymic gland are rare malignancies. Foreword.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(10 Suppl 4):S259.
2010: Min Chen; Donna Voeller; Victor E Marquez; Frederic J Kaye; Patricia S Steeg; Giuseppe Giaccone; Maria Zajac-Kaye
Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.
International journal of oncology 2010;37(4):963-71.
2010: Ronan J Kelly; Corey Carter; Giuseppe Giaccone
Personalizing therapy in an epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer using PF-00299804 and trastuzumab.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(28):e507-10.
2010: Ronan J Kelly; Giuseppe Giaccone
The role of talactoferrin alpha in the treatment of non-small cell lung cancer.
Expert opinion on biological therapy 2010;10(9):1379-86.
2010: Iacopo Petrini; Paolo Andrea Zucali; Hye Seung Lee; Marbin A Pineda; Paul S Meltzer; Beatriz Walter-Rodriguez; Massimo Roncalli; Armando Santoro; Yisong Wang; Giuseppe Giaccone
Expression and mutational status of c-kit in thymic epithelial tumors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(9):1447-53.
2010: Jane Trepel; Mehdi Mollapour; Giuseppe Giaccone; Len Neckers
Targeting the dynamic HSP90 complex in cancer.
Nature reviews. Cancer 2010;10(8):537-49.
2010: Ronan J Kelly; Sarah K Browne; Arun Rajan; Giuseppe Giaccone
Thymoma-associated paraneoplastic polymyositis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(22):e378.
2010: Johannes Voortman; Jih-Hsiang Lee; Jonathan Keith Killian; Miia Suuriniemi; Yonghong Wang; Marco Lucchi; William I Smith; Paul Meltzer; Yisong Wang; Giuseppe Giaccone
Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(29):13040-5.
2010: Terry W Moody; Marc J Berna; Samuel A Mantey; Veronica Sancho; Lisa A Ridnour; David A Wink; Daniel Chan; Giuseppe Giaccone; Robert T Jensen
Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells.
European journal of pharmacology 2010;637(1-3):38-45.
2010: Ronan J Kelly; James L Gulley; Giuseppe Giaccone
Targeting the immune system in non-small-cell lung cancer: bridging the gap between promising concept and therapeutic reality.
Clinical lung cancer 2010;11(4):228-37.
2010: Ariel Lopez-Chavez; Giuseppe Giaccone
Targeted therapies: Importance of patient selection for EGFR TKIs in lung cancer.
Nature reviews. Clinical oncology 2010;7(7):360-2.
2010: Adeline X Y Ge; Mary E Ryan; Giuseppe Giaccone; Marybeth S Hughes; Steven Z Pavletic
Acupuncture treatment for persistent hiccups in patients with cancer.
Journal of alternative and complementary medicine (New York, N.Y.) 2010;16(7):811-6.
2010: Federico Cappuzzo; tudor ciuleanu; Lilia Stelmakh; Saulius Cicenas; Aleksandra Szczésna; Erzsébet Juhász; Emilio Esteban; Olivier Molinier; Wolfram Brugger; Ivan Melezínek; Gaëlle Klingelschmitt; Barbara Klughammer; Giuseppe Giaccone
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study.
The lancet oncology 2010;11(6):521-9.
2010: Terry W Moody; Christopher Switzer; Wilmarie Santana-Flores; Lisa A Ridnour; Marc Berna; Michelle Thill; Robert T Jensen; Anna Sparatore; Piero Del Soldato; Grace C Yeh; David D Roberts; Giuseppe Giaccone; David A Wink
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.
Lung cancer (Amsterdam, Netherlands) 2010;68(2):154-60.
2010: Bart Kuenen; Petronella O Witteveen; Rita Ruijter; Giuseppe Giaccone; Aruna Dontabhaktuni; Floyd Fox; Terry Katz; Hagop Youssoufian; Junming Zhu; Eric K Rowinsky; Emile E Voest
A phase I pharmacologic study of necitumumab (IMC-11F8), a fully human IgG1 monoclonal antibody directed against EGFR in patients with advanced solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(6):1915-23.
2010: Christopher G Azzoli; Sherman Baker; Sarah Temin; William Pao; Timothy Aliff; Julie R Brahmer; David H Johnson; Janessa L Laskin; Gregory Masters; Daniel Milton; Luke Nordquist; David G Pfister; Steven Piantadosi; Joan H Schiller; Reily Smith; Thomas J Smith; John R Strawn; David Trent; Giuseppe Giaccone
[American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2010;13(3):171-89.
2010: Elisa Giovannetti; Paolo A Zucali; Godefridus J Peters; Filippo Cortesi; Armida D'Incecco; Egbert F Smit; Alfredo Falcone; Jacobus A Burgers; Armando Santoro; Romano Danesi; Giuseppe Giaccone; Carmelo Tibaldi
Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.
Molecular cancer therapeutics 2010;9(3):581-93.
2010: Hester van Cruijsen; Emile E Voest; Cornelis J A Punt; Klaas Hoekman; Petronella O Witteveen; Martijn R Meijerink; Thomas A Puchalski; Jane Robertson; Owain Saunders; Juliane M Jürgensmeier; Carla M L van Herpen; Giuseppe Giaccone
Phase I evaluation of cediranib, a selective VEGFR signalling inhibitor, in combination with gefitinib in patients with advanced tumours.
European journal of cancer (Oxford, England : 1990) 2010;46(5):901-11.
2010: Lokesh Jain; Tristan Sissung; Romano Danesi; Elise C Kohn; William L Dahut; Shivaani Kummar; David Venzon; David J Liewehr; Bevin C English; Caitlin E Baum; Robert Yarchoan; Giuseppe Giaccone; Jürgen Venitz; Douglas K Price; William D Figg
Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib.
Journal of experimental & clinical cancer research : CR 2010;29():95.
2010: Christopher G Azzoli; Giuseppe Giaccone; Sarah Temin
American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer.
Journal of oncology practice / American Society of Clinical Oncology 2010;6(1):39-43.
2010: Jin-Hyeok Hwang; Johannes Voortman; Elisa Giovannetti; Seth M Steinberg; Leticia G Leon; Yong-Tae Kim; Niccola Funel; Joo Kyung Park; Min A Kim; Gyeong Hoon Kang; Sun-Whe Kim; Marco Del Chiaro; Godefridus J Peters; Giuseppe Giaccone
Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer.
PloS one 2010;5(5):e10630.
2010: Frank C Detterbeck; Giuseppe Giaccone; Patrick Loehrer; Saul Suster; Cameron Wright
International thymic malignancy interest group.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(1):1-2.
2010: Shivaani Kummar; Martin E Gutierrez; Erin R Gardner; Xiaohong Chen; William D Figg; Maria Zajac-Kaye; Min Chen; Seth M Steinberg; Christine A Muir; Mary Ann Yancey; Yvonne R Horneffer; Lamin Juwara; Giovanni Melillo; S Percy Ivy; Maria Merino; Len Neckers; Patricia S Steeg; BA Conley; Giuseppe Giaccone; James Doroshow; Anthony J Murgo
Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies.
European journal of cancer (Oxford, England : 1990) 2010;46(2):340-7.
2010: Elisa Giovannetti; Richard Honeywell; Axel R Hanauske; Christina Tekle; Bart Kuenen; Jennifer Sigmond; Giuseppe Giaccone; Godefridus J Peters
Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).
Current drug targets 2010;11(1):12-28.
2009: Christopher G Azzoli; Sherman Baker; Sarah Temin; William Pao; Timothy Aliff; Julie R Brahmer; David H Johnson; Janessa L Laskin; Gregory Masters; Daniel Milton; Luke Nordquist; David G Pfister; Steven Piantadosi; Joan H Schiller; Reily Smith; Thomas J Smith; John R Strawn; David Trent; Giuseppe Giaccone
American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(36):6251-66.
2009: Ronan J Kelly; Oleh Hnatiuk; Giuseppe Giaccone
Antiangiogenesis induced tumor cavitation in lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(12):1573-5.
2009: Ariel Lopez-Chavez; Corey A Carter; Giuseppe Giaccone
The role of KRAS mutations in resistance to EGFR inhibition in the treatment of cancer.
Current opinion in investigational drugs (London, England : 2000) 2009;10(12):1305-14.
2009: Corey A Carter; Ronan J Kelly; Giuseppe Giaccone
Small-molecule inhibitors of the human epidermal receptor family.
Expert opinion on investigational drugs 2009;18(12):1829-42.
2009: Lucia Nogová; Ronald Boellaard; Carsten Kobe; Nikie Hoetjes; Thomas Zander; Stefan Hubert Gross; Sasa Dimitrijevic; Ted Pellas; Wolfgang Eschner; Katja Schmidt; Christopher Bangard; Wendy Hayes; Roman K Thomas; Markus Dietlein; Giuseppe Giaccone; Otto S Hoekstra; Adriaan A Lammertsma; Jürgen Wolf
Downregulation of 18F-FDG uptake in PET as an early pharmacodynamic effect in treatment of non-small cell lung cancer with the mTOR inhibitor everolimus.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(11):1815-9.
2009: Giuseppe Giaccone; Arun Rajan; Rita Ruijter; Egbert Smit; Cees van Groeningen; Pancras C W Hogendoorn
Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(10):1270-3.
2009: Jean-Charles Soria; F A Shepherd; Jean-Yves Douillard; J Wolf; Giuseppe Giaccone; Lucio Crino; F Cappuzzo; S Sharma; S H Gross; S Dimitrijevic; L Di Scala; H Gardner; L Nogova; V Papadimitrakopoulou
Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(10):1674-81.
2009: Giuseppe Giaccone; Petr Zatloukal; Jaromir Roubec; Karijn Floor; Jaromir Musil; Milan Kuta; Rob J van Klaveren; Subhash Chaudhary; Adrie Gunther; Setareh Shamsili
Multicenter phase II trial of YM155, a small-molecule suppressor of survivin, in patients with advanced, refractory, non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(27):4481-6.
2009: Giuseppe Giaccone; Arun Rajan
Met amplification and HSP90 inhibitors.
Cell cycle (Georgetown, Tex.) 2009;8(17):2682.
2009: J M van Riel; Godefridus J Peters; L H Mammatas; R J Honeywell; Adrie C Laan; R Ruyter; F G van den Berg; Giuseppe Giaccone; Cees J van Groeningen
A phase I and pharmacokinetic study of gemcitabine given by 24-h hepatic arterial infusion.
European journal of cancer (Oxford, England : 1990) 2009;45(14):2519-27.
2009: David M Jackman; Vincent A Miller; Leigh-Anne Cioffredi; Beow Y Yeap; Pasi A Janne; Gregory J Riely; Marielle Gallegos Ruiz; Giuseppe Giaccone; Lecia V Sequist; Bruce E Johnson
Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5267-73.
2009: Agnieszka Checińska; Giuseppe Giaccone; Jose A Rodriguez; Frank A E Kruyt; Connie R Jimenez
Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells.
Journal of proteomics 2009;72(4):575-85.
2009: Martin E Gutierrez; Shivaani Kummar; Giuseppe Giaccone
Next generation oncology drug development: opportunities and challenges.
Nature reviews. Clinical oncology 2009;6(5):259-65.
2009: Cecilia Ceresa; Elisa Giovannetti; Johannes Voortman; Adrie C Laan; Richard Honeywell; Giuseppe Giaccone; Godefridus J Peters
Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells.
Molecular cancer therapeutics 2009;8(5):1026-36.
2009: Shivaani Kummar; James Doroshow; Joseph E Tomaszewski; A Hilary Calvert; Marinus Lobbezoo; Giuseppe Giaccone
Phase 0 clinical trials: recommendations from the Task Force on Methodology for the Development of Innovative Cancer Therapies.
European journal of cancer (Oxford, England : 1990) 2009;45(5):741-6.
2009: Giuseppe Giaccone; Renee B Iacona; Abderrahim Fandi; Mette Janas; Judith S Ochs; Roy S Herbst; David H Johnson
Epidermal growth factor receptor expression analysis in chemotherapy-naive patients with advanced non-small-cell lung cancer treated with gefitinib or placebo in combination with platinum-based chemotherapy.
Journal of cancer research and clinical oncology 2009;135(3):467-76.
2009: M I Galleges Ruiz; Karijn Floor; S M Steinberg; Katrien Grunberg; F B J M Thunnissen; J A M Belien; Gerrit A Meijer; Godefridus J Peters; Egbert F Smit; Jose A Rodriguez; Giuseppe Giaccone
Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients.
British journal of cancer 2009;100(1):145-52.
2009: Corey A Carter; Arun Rajan; Giuseppe Giaccone
Plantar erythrodysesthesia with bullous otitis externa, toxicities from sorafenib: a case report.
Cases journal 2009;2():6264.
2009: Yeong Sang Kim; S V Alarcon; S Lee; Mao-Jung Lee; Giuseppe Giaccone; Len Neckers; Jane Trepel
Update on Hsp90 inhibitors in clinical trial.
Current topics in medicinal chemistry 2009;9(15):1479-92.
2009: Johannes Voortman; Thang V Pham; Jaco C Knol; Giuseppe Giaccone; Connie R Jimenez
Prediction of outcome of non-small cell lung cancer patients treated with chemotherapy and bortezomib by time-course MALDI-TOF-MS serum peptide profiling.
Proteome science 2009;7():34.
2009: Hester van Cruijsen; Mariëlle Gallegos Ruiz; Paul Van Der Valk; Tanja D de Gruijl; Giuseppe Giaccone
Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer.
BMC cancer 2009;9():180.
2009: Paul Roepman; Jacek Jassem; Egbert F Smit; Thomas Muley; Jacek Niklinski; Tony van de Velde; Anke T Witteveen; Witold Rzyman; Arno Floore; Sjaak Burgers; Giuseppe Giaccone; Michael Meister; Hendrik Dienemann; Marcin Skrzypski; Miroslaw Kozlowski; Wolter J Mooi; nico van zandwijk
An immune response enriched 72-gene prognostic profile for early-stage non-small-cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(1):284-90.
2008: Arun Rajan; Giuseppe Giaccone
Treatment of advanced thymoma and thymic carcinoma.
Current treatment options in oncology 2008;9(4-6):277-87.
2008: Min-Jung Lee; Yeong Sang Kim; Shivaani Kummar; Giuseppe Giaccone; Jane Trepel
Histone deacetylase inhibitors in cancer therapy.
Current opinion in oncology 2008;20(6):639-49.
2008: andrew bottomley; Channa Debruyne; Enriqueta Felip; Michael Millward; Luc Thiberville; Giannicola D'Addario; Lisa Rome; Petr Zatloukal; Corneel Coens; Giuseppe Giaccone
Symptom and quality of life results of an international randomised phase III study of adjuvant vaccination with Bec2/BCG in responding patients with limited disease small-cell lung cancer.
European journal of cancer (Oxford, England : 1990) 2008;44(15):2178-84.
2008: Lars R Perk; Marijke Stigter-van Walsum; Gerard W M Visser; Reina W Kloet; Maria J W D Vosjan; René Leemans; Giuseppe Giaccone; Raffaella Albano; Paolo M Comoglio; Guus A M S van Dongen
Quantitative PET imaging of Met-expressing human cancer xenografts with 89Zr-labelled monoclonal antibody DN30.
European journal of nuclear medicine and molecular imaging 2008;35(10):1857-67.
2008: Hester van Cruijsen; Astrid A M van der Veldt; Laura Vroling; Dinja Oosterhoff; Henk J Broxterman; Rik J Scheper; Giuseppe Giaccone; John B A G Haanen; Alfons J M van den Eertwegh; Epie Boven; Klaas Hoekman; Tanja D de Gruijl
Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5884-92.
2008: A Rajan; M Gutierrez; Giuseppe Giaccone
Newer opportunities in systemic therapy of lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19 Suppl 7():vii31-7.
2008: Linda E Bröker; Manuel Valdivieso; Mary Jo Pilat; Pamela Deluca; Xiaofei Zhou; Susan Parker; Giuseppe Giaccone; Patricia M LoRusso
Effect of food on the pharmacokinetic behavior of the potent oral taxane BMS-275183.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4186-91.
2008: Giuseppe Giaccone; P A Zucali
Src as a potential therapeutic target in non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(7):1219-23.
2008: Elisa Giovannetti; Clara Lemos; Christina Tekle; Kees Smid; Sara Nannizzi; José A Rodriguez; Simona Ricciardi; Romano Danesi; Giuseppe Giaccone; Godefridus J Peters
Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.
Molecular pharmacology 2008;73(4):1290-300.
2008: Fabrice Barlési; Giuseppe Giaccone; Marielle I Gallegos-Ruiz; Simone W Span; Pierre Lefesvre; Frank A E Kruyt; Jose Antonio Rodriguez
Genotype analysis of the VNTR polymorphism in the SMYD3 histone methyltransferase gene: lack of correlation with the level of histone H3 methylation in NSCLC tissues or with the risk of NSCLC.
International journal of cancer. Journal international du cancer 2008;122(6):1441-2.
2008: Martin Gutierrez; Giuseppe Giaccone
Antiangiogenic therapy in nonsmall cell lung cancer.
Current opinion in oncology 2008;20(2):176-82.
2008: David A Eberhard; Giuseppe Giaccone; Bruce E Johnson
Biomarkers of response to epidermal growth factor receptor inhibitors in Non-Small-Cell Lung Cancer Working Group: standardization for use in the clinical trial setting.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(6):983-94.
2008: Mariëlle I Gallegos-Ruiz; Karijn Floor; Paul Roepman; José A Rodriguez; Gerrit A Meijer; Wolter J Mooi; Ewa Jassem; Jacek Niklinski; Thomas Muley; nico van zandwijk; Egbert F Smit; Kristin Beebe; Len Neckers; Bauke Ylstra; Giuseppe Giaccone
Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target.
PloS one 2008;3(3):e0001722.
2008: Christopher M Booth; A Hilary Calvert; Giuseppe Giaccone; Marinus W Lobbezoo; Lesley K Seymour; Elizabeth A Eisenhauer
Endpoints and other considerations in phase I studies of targeted anticancer therapy: recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies (MDICT).
European journal of cancer (Oxford, England : 1990) 2008;44(1):19-24.
2008: Christopher M Booth; A Hilary Calvert; Giuseppe Giaccone; Marinus W Lobbezoo; Elizabeth A Eisenhauer; Lesley K Seymour
Design and conduct of phase II studies of targeted anticancer therapy: recommendations from the task force on methodology for the development of innovative cancer therapies (MDICT).
European journal of cancer (Oxford, England : 1990) 2008;44(1):25-9.
2007: Giuseppe Giaccone
18Fluorodeoxyglucose positron emission tomography, a standard diagnostic tool in lung cancer.
Journal of the National Cancer Institute 2007;99(23):1741-3.
2007: Mariëlle I Gallegos-Ruiz; Karijn Floor; Wim Vos; Katrien Grunberg; Gerrit A Meijer; Jose A Rodriguez; Giuseppe Giaccone
Epidermal growth factor receptor (EGFR) gene copy number detection in non-small-cell lung cancer; a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization.
Histopathology 2007;51(5):631-7.
2007: Dieuwke Engelsma; Jose A Rodriguez; Alexander Fish; Giuseppe Giaccone; Maarten Fornerod
Homodimerization antagonizes nuclear export of survivin.
Traffic (Copenhagen, Denmark) 2007;8(11):1495-502.
2007: Fabrice Barlési; Giuseppe Giaccone; Mariëlle I Gallegos-Ruiz; ANDERSON DIEUDONNE LOUNDOU; Simone W Span; Pierre Lefesvre; Frank A E Kruyt; Jose A Rodriguez
Global histone modifications predict prognosis of resected non small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(28):4358-64.
2007: Johannes Voortman; Tatiana P Resende; Mohamed A I Abou El Hassan; Giuseppe Giaccone; Frank A E Kruyt
TRAIL therapy in non-small cell lung cancer cells: sensitization to death receptor-mediated apoptosis by proteasome inhibitor bortezomib.
Molecular cancer therapeutics 2007;6(7):2103-12.
2007: Linda E Bröker; Stephan A Veltkamp; Elisabeth Iljas Heath; Bart C Kuenen; Helen Gall; Ludovic Astier; Susan Parker; Louis Kayitalire; Patricia M LoRusso; Jan H M Schellens; Giuseppe Giaccone
A phase I safety and pharmacologic study of a twice weekly dosing regimen of the oral taxane BMS-275183.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(13):3906-12.
2007: Martijn R Meijerink; Hester van Cruijsen; Klaas Hoekman; Matthijs Kater; Cors van Schaik; Jan-Hein T M van Waesberghe; Giuseppe Giaccone; Radu A Manoliu
The use of perfusion CT for the evaluation of therapy combining AZD2171 with gefitinib in cancer patients.
European radiology 2007;17(7):1700-13.
2007: Johannes Voortman; Egbert F Smit; Richard Honeywell; Bart C Kuenen; Godefridus J Peters; Helgi van de Velde; Giuseppe Giaccone
A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(12):3642-51.
2007: Connie R Jimenez; Zineb El Filali; Jaco C Knol; Klaas Hoekman; Frank A E Kruyt; Giuseppe Giaccone; August B Smit; Ka Wan Li
Automated serum peptide profiling using novel magnetic C18 beads off-line coupled to MALDI-TOF-MS.
Proteomics. Clinical applications 2007;1(6):598-604.
2007: Giuseppe Giaccone
Advances at the Center for Cancer Research at the National Cancer Institute's Medical Oncology Branch.
Clinical advances in hematology & oncology : H&O 2007;5(6):443-4, 459.
2007: Giuseppe Giaccone
The potential of antiangiogenic therapy in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):1961-70.
2007: Barbara Vischioni; Joost Oudejans; Frank A E Kruyt; Giuseppe Giaccone; Jose A Rodriguez
Immunohistochemical detection of nuclear survivin in NSCLC: a comparison of commercial antibodies.
Histopathology 2007;50(5):671-5.
2007: Agnieszka Checinska; Bas S J Hoogeland; Jose A Rodriguez; Giuseppe Giaccone; Frank A E Kruyt
Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells: a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation.
Experimental cell research 2007;313(6):1215-24.
2007: Jan P van Meerbeeck; Gijsbert W P M Kramer; Paul E Y Van Schil; Catherine Legrand; Egbert F Smit; Franz Schramel; Vivianne C G Tjan-Heijnen; Bonne Biesma; Channa Debruyne; nico van zandwijk; Ted A W Splinter; Giuseppe Giaccone
Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer.
Journal of the National Cancer Institute 2007;99(6):442-50.
2007: Johannes Voortman; Agnieszka Checinska; Giuseppe Giaccone; Jose A Rodriguez; Frank A E Kruyt
Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non-small cell lung cancer cell line NCI-H460.
Molecular cancer therapeutics 2007;6(3):1046-53.
2007: Richard Honeywell; Adrie C Laan; Cees J van Groeningen; E Strocchi; R Ruiter; Giuseppe Giaccone; Godefridus J Peters
The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;847(2):142-52.
2007: Herlinde Dumez; Helen Gall; Renaud Capdeville; Catherine Dutreix; Allan T van Oosterom; Giuseppe Giaccone
A phase I and pharmacokinetic study of LAF389 administered to patients with advanced cancer.
Anti-cancer drugs 2007;18(2):219-25.
2007: Hester van Cruijsen; Klaas Hoekman; A G M Stam; Alfons J M van den Eertwegh; Bart C Kuenen; Rik J Scheper; Giuseppe Giaccone; Tanja D de Gruijl
Defective differentiation of myeloid and plasmacytoid dendritic cells in advanced cancer patients is not normalized by tyrosine kinase inhibition of the vascular endothelial growth factor receptor.
Clinical & developmental immunology 2007;2007():17315.
2007: Johannes Voortman; Agnieszka Checińska; Giuseppe Giaccone
The proteasomal and apoptotic phenotype determine bortezomib sensitivity of non-small cell lung cancer cells.
Molecular cancer 2007;6():73.
2007: Georgios Kesisis; Henk Broxterman; Giuseppe Giaccone
Angiogenesis inhibitors. Drug selectivity and target specificity.
Current pharmaceutical design 2007;13(27):2795-809.
2007: Matheus M de Gunst; Mariëlle I Gallegos-Ruiz; Giuseppe Giaccone; Jose A Rodriguez
Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain.
Molecular cancer 2007;6():56.
2007: Mariëlle I Gallegos-Ruiz; Karijn Floor; Frank Rijmen; Katrien Grunberg; Jose A Rodriguez; Giuseppe Giaccone
EGFR and K-ras mutation analysis in non-small cell lung cancer: comparison of paraffin embedded versus frozen specimens.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2007;29(3):257-64.
2007: Mariëlle I Gallegos-Ruiz; Hester van Cruijsen; Egbert F Smit; Katrien Grunberg; Gerrit A Meijer; Jose A Rodriguez; Bauke Ylstra; Giuseppe Giaccone
Genetic heterogeneity in patients with multiple neoplastic lung lesions: a report of three cases.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007;2(1):12-21.
2007: José S A Belderbos; Lon Uitterhoeve; nico van zandwijk; Huub Belderbos; Patrick T R Rodrigus; Paul van de Vaart; Allan Price; Nico van Walree; Catherine Legrand; Sonia Dussenne; Harry Bartelink; Giuseppe Giaccone; Caro Koning
Randomised trial of sequential versus concurrent chemo-radiotherapy in patients with inoperable non-small cell lung cancer (EORTC 08972-22973).
European journal of cancer (Oxford, England : 1990) 2007;43(1):114-21.
2006: Mark G Kris; Giuseppe Giaccone; Angela Davies; Masahiro Fukuoka; David H Garfield; Jacek Jassem; Elisabeth Quoix; Alan B Sandler; Giorgio V Scagliotti; Jan P van Meerbeeck; Howard West
Systemic therapy of bronchioloalveolar carcinoma: results of the first IASLC/ASCO consensus conference on bronchioloalveolar carcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9 Suppl):S32-6.
2006: Michaela Achille; Marielle Gallegos-Ruiz; Giuseppe Giaccone; Jean-Charles Soria
Response to erlotinib in first-line treatment of non-small-cell lung cancer in a white male smoker with squamous-cell histology.
Clinical lung cancer 2006;8(3):214-6.
2006: Barbara Vischioni; Joost Oudejans; Wim Vos; Jose A Rodriguez; Giuseppe Giaccone
Frequent overexpression of aurora B kinase, a novel drug target, in non-small cell lung carcinoma patients.
Molecular cancer therapeutics 2006;5(11):2905-13.
2006: Paolo A Zucali; Giuseppe Giaccone
Biology and management of malignant pleural mesothelioma.
European journal of cancer (Oxford, England : 1990) 2006;42(16):2706-14.
2006: Fabio Efficace; andrew bottomley; Egbert F Smit; Pilar Lianes; Catherine Legrand; Channa Debruyne; Franz Schramel; Hans J M Smit; Rabab Mohamed Gaafar; Bonne Biesma; Christian Manegold; Corneel Coens; Giuseppe Giaccone; Jan P van Meerbeeck
Is a patient's self-reported health-related quality of life a prognostic factor for survival in non-small-cell lung cancer patients? A multivariate analysis of prognostic factors of EORTC study 08975.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(11):1698-704.
2006: Bernard M Tijink; Jan Buter; Remco de Bree; Giuseppe Giaccone; Margreet S Lang; Alexander Staab; René Leemans; Guus A M S van Dongen
A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):6064-72.
2006: Giuseppe Giaccone; Marielle Gallegos Ruiz; Thierry Le Chevalier; Nick Thatcher; Egbert Smit; Jose A Rodriguez; Pasi A Janne; Dalila Oulid-Aissa; Jean-Charles Soria
Erlotinib for frontline treatment of advanced non-small cell lung cancer: a phase II study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):6049-55.
2006: Jorine H Savonije; Cees J van Groeningen; W J M van den Broek; M E M Rentinck; Frans H M Corstens; Chad Gundy; Giuseppe Giaccone; Joannes Marx
Iron absorption during epoetin alfa therapy for chemotherapy-associated anaemia.
Cancer investigation 2006;24(6):562-6.
2006: Judith R Kroep; Egbert F Smit; Giuseppe Giaccone; Kasper van der Born; Jos H Beijnen; Cees J van Groeningen; Wim J F van der Vijgh; Pieter E Postmus; HERBERT PINEDO; Godefridus J Peters
Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.
Cancer chemotherapy and pharmacology 2006;58(4):509-16.
2006: Agnieszka Checinska; Joost Oudejans; Simone W Span; Jose A Rodriguez; Frank A E Kruyt; Giuseppe Giaccone
The expression of TUCAN, an inhibitor of apoptosis protein, in patients with advanced non-small cell lung cancer treated with chemotherapy.
Anticancer research 2006;26(5B):3819-24.
2006: Jose A Rodriguez; Susanne M A Lens; Simone W Span; Gerben Vader; René H Medema; Frank A E Kruyt; Giuseppe Giaccone
Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown.
Oncogene 2006;25(35):4867-79.
2006: Giuseppe Giaccone; Hanneke Wilmink; Marinus A Paul; Paul Van Der Valk
Systemic treatment of malignant thymoma: a decade experience at a single institution.
American journal of clinical oncology 2006;29(4):336-44.
2006: Gijsbert W P M Kramer; Catherine L Legrand; Paul Van Schil; Lon Uitterhoeve; Egbert F Smit; Franz Schramel; Bonne Biesma; Vivianne C G Tjan-Heijnen; nico van zandwijk; Ted A W Splinter; Giuseppe Giaccone; Jan P van Meerbeeck
Quality assurance of thoracic radiotherapy in EORTC 08941: a randomised trial of surgery versus thoracic radiotherapy in patients with stage IIIA non-small-cell lung cancer (NSCLC) after response to induction chemotherapy.
European journal of cancer (Oxford, England : 1990) 2006;42(10):1391-8.
2006: Adriaan A Lammertsma; Corneline Hoekstra; Giuseppe Giaccone; Otto S Hoekstra
How should we analyse FDG PET studies for monitoring tumour response?
European journal of nuclear medicine and molecular imaging 2006;33 Suppl 1():16-21.
2006: Maarten L Janmaat; Mariëlle I Gallegos-Ruiz; Jose A Rodriguez; Gerrit A Meijer; Walter L Vervenne; Dick J Richel; Cees Van Groeningen; Giuseppe Giaccone
Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(10):1612-9.
2006: Susanne M A Lens; Jose A Rodriguez; Gerben Vader; Simone W Span; Giuseppe Giaccone; René H Medema
Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.
Molecular biology of the cell 2006;17(4):1897-909.
2006: andrew bottomley; Rabab Mohamed Gaafar; Rabab Gaafa; Christian Manegold; Sjaak A Burgers; Corneel Coens; Catherine Legrand; mark vincent; Giuseppe Giaccone; Jan P van Meerbeeck
Short-term treatment-related symptoms and quality of life: results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an EORTC Lung-Cancer Group and National Cancer Institute, Canada, Intergroup Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(9):1435-42.
2006: Linda E Bröker; Filip De Vos; Cees J van Groeningen; Bart C Kuenen; Helen Gall; Michael H Woo; Maurizio Voi; Jourik A Gietema; Elisabeth G E de Vries; Giuseppe Giaccone
Phase I trial with BMS-275183, a novel oral taxane with promising antitumor activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1760-7.
2006: Jose Antonio Rodriguez; Giuseppe Giaccone
Keynote comment: are large-scale cancer-genomics projects ready to use?
The lancet oncology 2006;7(3):190-1.
2006: Jorine H Savonije; Cees J van Groeningen; Lars W Wormhoudt; Giuseppe Giaccone
Early intervention with epoetin alfa during platinum-based chemotherapy: an analysis of the results of a multicenter, randomized, controlled trial based on initial hemoglobin level.
The oncologist 2006;11(2):206-16.
2006: Jorine H Savonije; Cees J van Groeningen; Lars W Wormhoudt; Giuseppe Giaccone
Early Intervention with epoetin alfa during platinum-based chemotherapy: an analysis of quality-of-life results of a multicenter, randomized, controlled trial compared with population normative data.
The oncologist 2006;11(2):197-205.
2006: Richard Honeywell; Cees J van Groeningen; Adrie C Laan; E Strocchi; R Ruiter; Giuseppe Giaccone; Godefridus J Peters
Analysis of deoxycytidine accumulation in gemcitabine treated patients.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1225-32.
2006: Agnieszka Checinska; Giuseppe Giaccone; Bas S J Hoogeland; Carlos G Ferreira; Jose A Rodriguez; Frank A E Kruyt
TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells.
BMC cancer 2006;6():166.
2006: Johannes Voortman; Giuseppe Giaccone
Severe reversible cardiac failure after bortezomib treatment combined with chemotherapy in a non-small cell lung cancer patient: a case report.
BMC cancer 2006;6():129.
2006: Barbara Vischioni; Paul Van Der Valk; Simone W Span; Frank A E Kruyt; Jose A Rodriguez; Giuseppe Giaccone
Expression and localization of inhibitor of apoptosis proteins in normal human tissues.
Human pathology 2006;37(1):78-86.
2006: Carolien H Smorenburg; Godefridus J Peters; Cees J van Groeningen; Paul Noordhuis; Kees Smid; A M G H van Riel; W Dercksen; HERBERT PINEDO; Giuseppe Giaccone
Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(1):35-42.
2006: Maarten L Janmaat; Jose A Rodriguez; Mariëlle Gallegos-Ruiz; Frank A E Kruyt; Giuseppe Giaccone
Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells.
International journal of cancer. Journal international du cancer 2006;118(1):209-14.
2005: Hester van Cruijsen; Giuseppe Giaccone; Klaas Hoekman
Epidermal growth factor receptor and angiogenesis: Opportunities for combined anticancer strategies.
International journal of cancer. Journal international du cancer 2005;117(6):883-8.
2005: Giuseppe Giaccone
The role of EGFR-TK inhibition in non-small cell lung cancer.
Onkologie 2005;28(12):619-20.
2005: Jan Buter; Giuseppe Giaccone
EGFR inhibitors in lung cancer.
Oncology (Williston Park, N.Y.) 2005;19(13):1707-11; discussion 1711-2, 1720-3.
2005: Giuseppe Giaccone; Jose Antonio Rodriguez
EGFR inhibitors: what have we learned from the treatment of lung cancer?
Nature clinical practice. Oncology 2005;2(11):554-61.
2005: Daphne W Bell; Thomas J Lynch; Sara M Haserlat; Patricia Neal; Ross A Okimoto; Brian W Brannigan; Dennis C Sgroi; Beth Muir; Markus J Riemenschneider; Renee Bailey Iacona; Annetta D Krebs; David H Johnson; Giuseppe Giaccone; Roy S Herbst; Christian Manegold; Masahiro Fukuoka; Mark G Kris; José Baselga; Judith S Ochs; Daniel A Haber
Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(31):8081-92.
2005: Heinz Ludwig; David Khayat; Giuseppe Giaccone; Thierry Facon
Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies.
Cancer 2005;104(9):1794-807.
2005: Jan P van Meerbeeck; Rabab Mohamed Gaafar; Christian Manegold; Rob J van Klaveren; Eric A Van Marck; mark vincent; Catherine Legrand; andrew bottomley; Channa Debruyne; Giuseppe Giaccone
Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(28):6881-9.
2005: Giuseppe Giaccone; Channa Debruyne; Enriqueta Felip; Paul B Chapman; Stefan C Grant; Michael Millward; Luc Thiberville; Giannicola D'Addario; Corneel Coens; Lisa S Rome; Petr Zatloukal; Oriol Masso; Catherine Legrand
Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(28):6854-64.
2005: Giorgio V Scagliotti; Egbert Smit; Lionel Bosquee; Mary O'Brien; Andrea Ardizzoni; Peter Zatloukal; Wilfried Eberhardt; Maartje Smid-Geirnaerdt; Hein G de Bruin; Sonia Dussenne; Catherine Legrand; Giuseppe Giaccone
A phase II study of paclitaxel in advanced bronchioloalveolar carcinoma (EORTC trial 08956).
Lung cancer (Amsterdam, Netherlands) 2005;50(1):91-6.
2005: A H G Hansma; Henk J Broxterman; I van der Horst; Yuana Yuana; Epie Boven; Giuseppe Giaccone; HERBERT PINEDO; Klaas Hoekman
Recombinant human endostatin administered as a 28-day continuous intravenous infusion, followed by daily subcutaneous injections: a phase I and pharmacokinetic study in patients with advanced cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(10):1695-701.
2005: Bart C Kuenen; Giuseppe Giaccone; Rita Ruijter; astrid kok; Casper G Schalkwijk; Klaas Hoekman; HERBERT PINEDO
Dose-finding study of the multitargeted tyrosine kinase inhibitor SU6668 in patients with advanced malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6240-6.
2005: Giuseppe Giaccone
Targeting HER1/EGFR in cancer therapy: experience with erlotinib.
Future oncology (London, England) 2005;1(4):449-60.
2005: Maarten L Janmaat; Jose A Rodriguez; José Jimeno; Frank A E Kruyt; Giuseppe Giaccone
Kahalalide F induces necrosis-like cell death that involves depletion of ErbB3 and inhibition of Akt signaling.
Molecular pharmacology 2005;68(2):502-10.
2005: Jorine H Savonije; Cees J van Groeningen; Aart van Bochove; Aafke H Honkoop; C L van Felius; Lars W Wormhoudt; Giuseppe Giaccone
Effects of early intervention with epoetin alfa on transfusion requirement, hemoglobin level and survival during platinum-based chemotherapy: Results of a multicenter randomised controlled trial.
European journal of cancer (Oxford, England : 1990) 2005;41(11):1560-9.
2005: Carin A Uyl-de Groot; Giuseppe Giaccone
Health economics: can we afford an unrestricted use of new biological agents in gastrointestinal oncology?
Current opinion in oncology 2005;17(4):392-6.
2005: Giuseppe Giaccone
EGFR point mutation confers resistance to gefitinib in a patient with non-small-cell lung cancer.
Nature clinical practice. Oncology 2005;2(6):296-7.
2005: Miriam Ferrer; Jose A Rodríguez; Ellen A Spierings; Johan P de Winter; Giuseppe Giaccone; Frank A E Kruyt
Identification of multiple nuclear export sequences in Fanconi anemia group A protein that contribute to CRM1-dependent nuclear export.
Human molecular genetics 2005;14(10):1271-81.
2005: Giuseppe Giaccone
Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(14):3235-42.
2005: Epie Boven; Marjan J Westerman; Cees J van Groeningen; Miranda Verschraagen; Rita Ruijter; I Zegers; Wim J F van der Vijgh; Giuseppe Giaccone
Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule.
British journal of cancer 2005;92(9):1636-43.
2005: Linda E Bröker; Frank A E Kruyt; Giuseppe Giaccone
Cell death independent of caspases: a review.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(9):3155-62.
2005: Giuseppe Giaccone
HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(4):538-48.
2005: Dinja Oosterhoff; Renée M Overmeer; Michelle de Graaf; I H van der Meulen; Giuseppe Giaccone; Victor W van Beusechem; Hidde J Haisma; HERBERT PINEDO; Winald Gerritsen
Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11.
British journal of cancer 2005;92(5):882-7.
2005: Giuseppe Giaccone
Treatment of malignant thymoma.
Current opinion in oncology 2005;17(2):140-6.
2005: Giuseppe Giaccone; Egbert Smit
Lung cancer.
Cancer chemotherapy and biological response modifiers 2005;22():413-42.
2005: Jan Buter; Giuseppe Giaccone
Medical treatment of non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16 Suppl 2():ii229-32.
2005: Miriam Ferrer; Simone W Span; Barbara Vischioni; Joost Oudejans; Paulus van Diest; Johan P de Winter; Giuseppe Giaccone; Frank A E Kruyt
FANCD2 expression in advanced non-small-cell lung cancer and response to platinum-based chemotherapy.
Clinical lung cancer 2005;6(4):250-4.
2004: Luca Roz; Francesca Andriani; Carlos G Ferreira; Giuseppe Giaccone; Gabriella Sozzi
The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl-2 or Bcl-x(L) overexpression.
Oncogene 2004;23(56):9102-10.
2004: Barbara Vischioni; Paul Van Der Valk; Simone W Span; Frank A E Kruyt; Jose A Rodriguez; Giuseppe Giaccone
Nuclear localization of survivin is a positive prognostic factor for survival in advanced non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(11):1654-60.
2004: Birgit Geoerger; Gilles Vassal; Paule Opolon; Clemens M F Dirven; Jackie Morizet; Lysiane Laudani; jacques grill; Giuseppe Giaccone; W Peter Vandertop; Winald Gerritsen; Victor W van Beusechem
Oncolytic activity of p53-expressing conditionally replicative adenovirus AdDelta24-p53 against human malignant glioma.
Cancer research 2004;64(16):5753-9.
2004: Barbara Vischioni; Giuseppe Giaccone; Simone W Span; Frank A E Kruyt; Jose A Rodriguez
Nuclear shuttling and TRAF2-mediated retention in the cytoplasm regulate the subcellular localization of cIAP1 and cIAP2.
Experimental cell research 2004;298(2):535-48.
2004: Miriam Ferrer; Johan P de Winter; D C Jeroen Mastenbroek; David T Curiel; Winald Gerritsen; Giuseppe Giaccone; Frank A E Kruyt
Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA.
Cancer gene therapy 2004;11(8):539-46.
2004: Mohamed A I Abou El Hassan; D C Jeroen Mastenbroek; Winald Gerritsen; Giuseppe Giaccone; Frank A E Kruyt
Overexpression of Bcl2 abrogates chemo- and radiotherapy-induced sensitisation of NCI-H460 non-small-cell lung cancer cells to adenovirus-mediated expression of full-length TRAIL.
British journal of cancer 2004;91(1):171-7.
2004: N Croles; Carolien H Smorenburg; Cees J van Groeningen; Giuseppe Giaccone; Epie Boven
FOLFOX3 in heavily pretreated patients with metastatic colorectal cancer.
The Netherlands journal of medicine 2004;62(7):242-5.
2004: Hans J J van der Vliet; Johan Molling; B Mary E von Blomberg; Nobusuke Nishi; Wendy Kölgen; Alfons J M van den Eertwegh; HERBERT PINEDO; Giuseppe Giaccone; Rik J Scheper
The immunoregulatory role of CD1d-restricted natural killer T cells in disease.
Clinical immunology (Orlando, Fla.) 2004;112(1):8-23.
2004: Giuseppe Giaccone
The role of gefitinib in lung cancer treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 2):4233s-4237s.
2004: Thomas J Lynch; Alex A. Adjei; Paul A Bunn; Raymond DuBois; David R Gandara; Giuseppe Giaccone; Ramaswamy Govindan; Roy S Herbst; Bruce E Johnson; Fadlo R Khuri; Roman Perez-Soler; Rafael Rosell; Eric K Rowinsky; Alan B Sandler; Giorgio V Scagliotti; Joan H Schiller; Geoffrey I Shapiro; Mark A Socinski; Carol S Hart
Novel agents in the treatment of lung cancer: conference summary statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 2):4199s-4204s.
2004: Godefridus J Peters; Paul Noordhuis; Cees J van Groeningen; Giuseppe Giaccone; Ulbe Holwerda; Daphne Voorn; Ad Schrijvers; Jan H Schornagel; Jos H Beijnen; Pierre Fumoleau; Jan H M Schellens
The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):4072-6.
2004: Giuseppe Giaccone; J L González-Larriba; A T van Oosterom; R Alfonso; Egbert F Smit; M Martens; Godefridus J Peters; Wim J F van der Vijgh; R Smith; Steven D Averbuch; Abderrahim Fandi
Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(5):831-8.
2004: Giuseppe Giaccone; Egbert F Smit; M de Jonge; E Dansin; Evangelos Briasoulis; Andrea Ardizzoni; Jean-Yves Douillard; Dominique Spaeth; D Lacombe; B Baron; P Bachmann; Pierre Fumoleau
Glufosfamide administered by 1-hour infusion as a second-line treatment for advanced non-small cell lung cancer; a phase II trial of the EORTC-New Drug Development Group.
European journal of cancer (Oxford, England : 1990) 2004;40(5):667-72.
2004: SM de Lange; Cees J van Groeningen; Judith R Kroep; Aart van Bochove; J F Snijders; Godefridus J Peters; HERBERT PINEDO; Giuseppe Giaccone
Phase II trial of cisplatin and gemcitabine in patients with advanced gastric cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(3):484-8.
2004: Roy S Herbst; Giuseppe Giaccone; Joan H Schiller; Ronald B Natale; Vincent A Miller; Christian Manegold; Giorgio V Scagliotti; Rafael Rosell; Ira Oliff; James A Reeves; Michael K Wolf; Annetta D Krebs; Steven D Averbuch; Judith S Ochs; John Grous; Abderrahim Fandi; David H Johnson
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 2.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(5):785-94.
2004: Giuseppe Giaccone; Roy S Herbst; Christian Manegold; Giorgio V Scagliotti; Rafael Rosell; Vincent A Miller; Ronald B Natale; Joan H Schiller; Joachim von Pawel; Anna Pluzanska; Ulrich Gatzemeier; John Grous; Judith S Ochs; Steven D Averbuch; Michael K Wolf; Pamela Rennie; Abderrahim Fandi; David H Johnson
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(5):777-84.
2004: Judith R Kroep; HERBERT PINEDO; Giuseppe Giaccone; Aart van Bochove; Godefridus J Peters; Cees J van Groeningen
Phase II study of cisplatin preceding gemcitabine in patients with advanced oesophageal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(2):230-5.
2004: Giuseppe Giaccone
Twenty-five years of treating advanced NSCLC: what have we achieved?
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15 Suppl 4():iv81-3.
2004: Linda E Bröker; Cynthia Huisman; Simone W Span; Jose A Rodriguez; Frank A E Kruyt; Giuseppe Giaccone
Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells.
Cancer research 2004;64(1):27-30.
2004: Rob J van Klaveren; Joachim G J V Aerts; Hein de Bruin; Giuseppe Giaccone; Christian Manegold; Jan P van Meerbeeck
Inadequacy of the RECIST criteria for response evaluation in patients with malignant pleural mesothelioma.
Lung cancer (Amsterdam, Netherlands) 2004;43(1):63-9.
2004: J M G H van Riel; Cees J van Groeningen; J de Greve; G Gruia; HERBERT PINEDO; Giuseppe Giaccone
Continuous infusion of hepatic arterial irinotecan in pretreated patients with colorectal cancer metastatic to the liver.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2004;15(1):59-63.
2003: Egbert F Smit; Jan P van Meerbeeck; Pilar Lianes; Channa Debruyne; Catherine Legrand; Franz Schramel; Hans Smit; Rabab Mohamed Gaafar; Bonne Biesma; Chris Manegold; Niels Neymark; Giuseppe Giaccone
Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group--EORTC 08975.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(21):3909-17.
2003: Frank A E Kruyt; Agnieszka Checinska; Giuseppe Giaccone; Carlos G Ferreira
Correspondence re: L. Yang et al., Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res., 63: 831-837, 2003.
Cancer research 2003;63(19):6566-7; author reply 6568.
2003: Giorgio V Scagliotti; Roldano Fossati; Valter Torri; Lucio Crinò; Giuseppe Giaccone; Giovanni Silvano; Massimo Martelli; Maurizia Clerici; Francesco Cognetti; Maurizio Tonato
Randomized study of adjuvant chemotherapy for completely resected stage I, II, or IIIA non-small-cell Lung cancer.
Journal of the National Cancer Institute 2003;95(19):1453-61.
2003: Paul A Bunn; Frances A Shepherd; Alan B Sandler; Thierry Le Chevalier; Chandra P Belani; Paris A Kosmidis; Giorgio V Scagliotti; Giuseppe Giaccone
Ongoing and future trials of biologic therapies in lung cancer.
Lung cancer (Amsterdam, Netherlands) 2003;41 Suppl 1():S175-86.
2003: Fred R Hirsch; Paul A Bunn; David H Johnson; Giuseppe Giaccone; Rafael Rosell
Lung cancer. Introduction.
Lung cancer (Amsterdam, Netherlands) 2003;41 Suppl 1():S1.
2003: Hans J J van der Vliet; Johan Molling; Nobusuke Nishi; Allan J Masterson; Wendy Kölgen; Steven A Porcelli; Alfons J M van den Eertwegh; B Mary E von Blomberg; HERBERT PINEDO; Giuseppe Giaccone; Rik J Scheper
Polarization of Valpha24+ Vbeta11+ natural killer T cells of healthy volunteers and cancer patients using alpha-galactosylceramide-loaded and environmentally instructed dendritic cells.
Cancer research 2003;63(14):4101-6.
2003: M E R O'Brien; Ted A W Splinter; Egbert F Smit; Bonne Biesma; Maciej Krzakowski; Vivianne C G Tjan-Heijnen; Aart van Bochove; J Stigt; M J A Smid-Geirnaerdt; Channa Debruyne; Catherine Legrand; Giuseppe Giaccone
Carboplatin and paclitaxol (Taxol) as an induction regimen for patients with biopsy-proven stage IIIA N2 non-small cell lung cancer. an EORTC phase II study (EORTC 08958).
European journal of cancer (Oxford, England : 1990) 2003;39(10):1416-22.
2003: Godefridus J Peters; Paul Noordhuis; André B P van Kuilenburg; Jan H Schornagel; Helen Gall; S L Turner; M S Swart; Daphne Voorn; A H Van Gennip; J Wanders; Ulbe Holwerda; Kees Smid; Giuseppe Giaccone; Pierre Fumoleau; Cees J van Groeningen
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Cancer chemotherapy and pharmacology 2003;52(1):1-12.
2003: Jose A Rodriguez; Simone W Span; Frank A E Kruyt; Giuseppe Giaccone
Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins.
The Biochemical journal 2003;373(Pt 1):251-9.
2003: Masahiro Fukuoka; Seiji Yano; Giuseppe Giaccone; Tomohide Tamura; Kazuhiko Nakagawa; Jean-Yves Douillard; Yutaka Nishiwaki; Johan Vansteenkiste; Shinzoh Kudoh; Danny Rischin; Richard Eek; Takeshi Horai; Kazumasa Noda; Ichiro Takata; Egbert Smit; Steven D Averbuch; Angela Macleod; Andrea Feyereislova; Rui-Ping Dong; José Baselga
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected].
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(12):2237-46.
2003: Miriam Ferrer; Thijs Izeboud; Carlos G Ferreira; Simone W Span; Giuseppe Giaccone; Frank A E Kruyt
Cisplatin triggers apoptotic or nonapoptotic cell death in Fanconi anemia lymphoblasts in a concentration-dependent manner.
Experimental cell research 2003;286(2):381-95.
2003: Maarten L Janmaat; Frank A E Kruyt; Jose A Rodriguez; Giuseppe Giaccone
Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):2316-26.
2003: Rafal Dziadziuszko; Andrea Ardizzoni; Pieter E Postmus; Egbert F Smit; A Price; Channa Debruyne; Catherine Legrand; Giuseppe Giaccone
Temozolomide in patients with advanced non-small cell lung cancer with and without brain metastases. a phase II study of the EORTC Lung Cancer Group (08965).
European journal of cancer (Oxford, England : 1990) 2003;39(9):1271-6.
2003: Paul Baas; Andrea Ardizzoni; Francesco Grossi; K Nackaerts; Gianmauro Numico; E Van Marck; Marc J van de Vijver; Francesco Monetti; M J A Smid-Geirnaerdt; nico van zandwijk; Channa Debruyne; Catherine Legrand; Giuseppe Giaccone
The activity of raltitrexed (Tomudex) in malignant pleural mesothelioma: an EORTC phase II study (08992).
European journal of cancer (Oxford, England : 1990) 2003;39(3):353-7.
2003: Vivianne C G Tjan-Heijnen; S Caleo; Pieter E Postmus; Andrea Ardizzoni; Jos Burghouts; E Buccholz; Bonne Biesma; Thierry Gorlia; R Crott; Giuseppe Giaccone; Channa Debruyne; Christian Manegold
Economic evaluation of antibiotic prophylaxis in small-cell lung cancer patients receiving chemotherapy: an EORTC double-blind placebo-controlled phase III study (08923).
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(2):248-57.
2003: Giuseppe Giaccone; Egbert Smit
Lung cancer.
Cancer chemotherapy and biological response modifiers 2003;21():445-83.
2003: Maarten L Janmaat; Giuseppe Giaccone
The epidermal growth factor receptor pathway and its inhibition as anticancer therapy.
Drugs of today (Barcelona, Spain : 1998) 2003;39 Suppl C():61-80.
2003: Maarten L Janmaat; Giuseppe Giaccone
Small-molecule epidermal growth factor receptor tyrosine kinase inhibitors.
The oncologist 2003;8(6):576-86.
2003: Marinus W Lobbezoo; Giuseppe Giaccone; Coenraad Van Kalken
Signal transduction modulators for cancer therapy: from promise to practice?
The oncologist 2003;8(2):210-3.
2002: Giuseppe Giaccone; Cornelis J A Punt; Yoshitaka Ando; Rita Ruijter; Nobusuke Nishi; Marlies Peters; B Mary E von Blomberg; Rik J Scheper; Hans J J van der Vliet; Alfons J M van den Eertwegh; Marja Roelvink; Jos Beijnen; Heinz Zwierzina; HERBERT PINEDO
A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3702-9.
2002: Linda E Bröker; Giuseppe Giaccone
The role of new agents in the treatment of non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990) 2002;38(18):2347-61.
2002: Frances A Shepherd; Giuseppe Giaccone; Lesley Seymour; Channa Debruyne; Andrea Bezjak; Vera Hirsh; Michael Smylie; Sheldon Rubin; Heidi Martins; Alan Lamont; Maciej Krzakowski; Anna Sadura; Benny Zee
Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(22):4434-9.
2002: Giuseppe Giaccone
Targeted therapy in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2002;38 Suppl 2():S29-32.
2002: Giuseppe Giaccone
Clinical impact of novel treatment strategies.
Oncogene 2002;21(45):6970-81.
2002: Andrea Ardizzoni; Vivianne C G Tjan-Heijnen; Pieter E Postmus; Erika Buchholz; Bonne Biesma; Hanna Karnicka-Mlodkowska; Rafal Dziadziuszko; Jos Burghouts; Jan P van Meerbeeck; Steven Gans; Catherine Legrand; Channa Debruyne; Giuseppe Giaccone; Christian Manegold
Standard versus intensified chemotherapy with granulocyte colony-stimulating factor support in small-cell lung cancer: a prospective European Organization for Research and Treatment of Cancer-Lung Cancer Group Phase III Trial-08923.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(19):3947-55.
2002: Hans J J van der Vliet; HERBERT PINEDO; B Mary E von Blomberg; Alfons J M van den Eertwegh; Rik J Scheper; Giuseppe Giaccone
Natural Killer T cells.
The lancet oncology 2002;3(9):574.
2002: Linda E Bröker; Cynthia Huisman; Carlos G Ferreira; Jose A Rodriguez; Frank A E Kruyt; Giuseppe Giaccone
Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells.
Cancer research 2002;62(14):4081-8.
2002: Carlos G Ferreira; Mirjam Epping; Frank A E Kruyt; Giuseppe Giaccone
Apoptosis: target of cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2024-34.
2002: Giuseppe Giaccone
Early results of a randomized phase III trial of platinum-containing doublets versus a nonplatinum doublet in the treatment of advanced non-small cell lung cancer: European Organization for Research and Treatment of Cancer 08975.
Seminars in oncology 2002;29(3 Suppl 9):47-9.
2002: SM de Lange; Cees J van Groeningen; O W M Meijer; Miguel A Cuesta; J A Langendijk; J M G H van Riel; HERBERT PINEDO; Godefridus J Peters; Sybren Meijer; Ben Slotman; Giuseppe Giaccone
Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer.
European journal of cancer (Oxford, England : 1990) 2002;38(9):1212-7.
2002: Arnold Baars; A M E Claessen; John Wagstaff; Giuseppe Giaccone; Rik J Scheper; Sybren Meijer; M J A G Schakel; Helen Gall; C J L M Meijer; Jan B Vermorken; HERBERT PINEDO; Alfons J M van den Eertwegh
A phase II study of active specific immunotherapy and 5-FU/Leucovorin as adjuvant therapy for stage III colon carcinoma.
British journal of cancer 2002;86(8):1230-4.
2002: Jose A Rodríguez; Simone W Span; Carlos G Ferreira; Frank A E Kruyt; Giuseppe Giaccone
CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin.
Experimental cell research 2002;275(1):44-53.
2002: Jan P van Meerbeeck; Paul Baas; Channa Debruyne; Egbert F Smit; Rob J van Klaveren; D Galdermans; M A Lentz; Christian Manegold; Giuseppe Giaccone
A phase II EORTC study of temozolomide in patients with malignant pleural mesothelioma.
European journal of cancer (Oxford, England : 1990) 2002;38(6):779-83.
2002: Mirjam Crul; Ron A A Mathôt; Giuseppe Giaccone; Cornelis A Punt; Hilde Rosing; Michel X Hillebrand; Yoshitaka Ando; Nobosuke Nishi; Hideji Tanaka; Jan M Schellens; Jos H Beijnen
Population pharmacokinetics of the novel anticancer agent KRN7000.
Cancer chemotherapy and pharmacology 2002;49(4):287-93.
2002: Bart C Kuenen; Lee Rosen; Egbert F Smit; Mandy R N Parson; Marcel Levi; Rita Ruijter; Holger Huisman; Marc A Kedde; Paul Noordhuis; Wim J F van der Vijgh; Godefridus J Peters; Gillian F Cropp; Paul Scigalla; Klaas Hoekman; HERBERT PINEDO; Giuseppe Giaccone
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(6):1657-67.
2002: Cynthia Huisman; Carlos G Ferreira; Linda E Bröker; Jose A Rodriguez; Egbert F Smit; Pieter E Postmus; Frank A E Kruyt; Giuseppe Giaccone
Paclitaxel triggers cell death primarily via caspase-independent routes in the non-small cell lung cancer cell line NCI-H460.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):596-606.
2002: J M G H van Riel; Cees J van Groeningen; Marc A Kedde; Helen Gall; Johanna M A Leisink; Gabriella Gruia; HERBERT PINEDO; Wim J F van der Vijgh; Giuseppe Giaccone
Continuous administration of irinotecan by hepatic arterial infusion: a phase I and pharmacokinetic study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):405-12.
2002: Hans J J van der Vliet; B Mary E von Blomberg; Mette D Hazenberg; Nobusuke Nishi; Sigrid A Otto; Birgit H B van Benthem; Maria Prins; Frans A Claessen; Alfons J M van den Eertwegh; Giuseppe Giaccone; Frank Miedema; Rik J Scheper; HERBERT PINEDO
Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1490-5.
2002: Giuseppe Giaccone; Egbert F Smit
Update on the systemic treatment of lung cancer.
Cancer chemotherapy and biological response modifiers 2002;20():697-716.
2002: T Cerny; Giuseppe Giaccone
Pleura mesothelioma: combined modality treatments.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13 Suppl 4():217-25.
2002: Carlos G Ferreira; Cynthia Huisman; Giuseppe Giaccone
Novel approaches to the treatment of non-small cell lung cancer.
Critical reviews in oncology/hematology 2002;41(1):57-77.
2001: Muhammed Hadithi; TJ van Boxem; Giuseppe Giaccone; Pieter E Postmus
Exercise-induced spontaneous hemothorax insinuates trauma; yet unmasks a lament disorder.
The Netherlands journal of medicine 2001;59(6):292-4.
2001: Cynthia Huisman; Bonne Biesma; Pieter E Postmus; Giuseppe Giaccone; Franz Schramel; Egbert F Smit
Accelerated cisplatin and high-dose epirubicin with G-CSF support in patients with relapsed non-small-cell lung cancer: feasibility and efficacy.
British journal of cancer 2001;85(10):1456-61.
2001: Cynthia Huisman; Pieter E Postmus; Giuseppe Giaccone; Egbert F Smit
A phase I study of sequential intravenous topotecan and etoposide in lung cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(11):1567-73.
2001: Giuseppe Giaccone
State of the art in systemic treatment of lung cancer.
European journal of cancer (Oxford, England : 1990) 2001;37 Suppl 7():S99-114.
2001: Vivianne C G Tjan-Heijnen; Pieter E Postmus; Andrea Ardizzoni; Christian Manegold; Jos Burghouts; Jan P van Meerbeeck; Steven Gans; M Mollers; Erika Buchholz; Bonne Biesma; Catherine Legrand; Channa Debruyne; Giuseppe Giaccone
Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: an EORTC double-blind placebo-controlled phase III study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(10):1359-68.
2001: Cynthia Huisman; Giuseppe Giaccone; C J van Groeningen; GT Sutedja; Pieter E Postmus; Egbert F Smit
Combination of gemcitabine and cisplatin for advanced non-small cell lung cancer: a phase II study with emphasis on scheduling.
Lung cancer (Amsterdam, Netherlands) 2001;33(2-3):267-75.
2001: Carlos G Ferreira; Paul Van Der Valk; Simone W Span; Irene S Ludwig; Egbert F Smit; Frank A E Kruyt; HERBERT PINEDO; Harm van Tinteren; Giuseppe Giaccone
Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2468-74.
2001: Hans J J van der Vliet; B Mary E von Blomberg; Nobusuke Nishi; M Reijm; Alexandre E Voskuyl; Ad van Bodegraven; C H Polman; Thomas Rustemeyer; P Lips; Alfons J M van den Eertwegh; Giuseppe Giaccone; Rik J Scheper; HERBERT PINEDO
Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage.
Clinical immunology (Orlando, Fla.) 2001;100(2):144-8.
2001: Carlos G Ferreira; Paul Van Der Valk; Simone W Span; J M Jonker; Pieter E Postmus; Frank A E Kruyt; Giuseppe Giaccone
Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(6):799-805.
2001: Jorine H Savonije; B W Spanier; Cees J van Groeningen; Giuseppe Giaccone; HERBERT PINEDO
[Decline in the need for blood transfusions in cancer patients due to the use of epoietin alfa during cisplatin based chemotherapy].
Nederlands tijdschrift voor geneeskunde 2001;145(18):878-81.
2001: A C Dingemans; J van Ark-Otte; Simone W Span; Giorgio V Scagliotti; Paul Van Der Valk; Pieter E Postmus; Giuseppe Giaccone
Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2001;32(2):117-28.
2001: Harold H J Backus; Danny F Dukers; Cees J van Groeningen; Wim Vos; Elisabeth Bloemena; Dorine Wouters; J M G H van Riel; Kees Smid; Giuseppe Giaccone; HERBERT PINEDO; Godefridus J Peters
5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(2):209-16.
2001: Giuseppe Giaccone; Egbert F Smit
Lung cancer.
Cancer chemotherapy and biological response modifiers 2001;19():485-534.
2001: Scott B Johnson; Tony Y Eng; Giuseppe Giaccone; Charles Thomas
Thymoma: update for the new millennium.
The oncologist 2001;6(3):239-46.
2001: Nobusuke Nishi; Yasuhiko Koezuka; Steven A Porcelli; HERBERT PINEDO; Rik J Scheper; Giuseppe Giaccone
Potent expansion of human natural killer T cells using alpha-galactosylceramide (KRN7000)-loaded monocyte-derived dendritic cells, cultured in the presence of IL-7 and IL-15.
Journal of immunological methods 2001;247(1-2):61-72.
2000: Carlos G Ferreira; Simone W Span; Godefridus J Peters; Frank A E Kruyt; Giuseppe Giaccone
Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.
Cancer research 2000;60(24):7133-41.
2000: J M G H van Riel; Cees J van Groeningen; S H Albers; Marcel Cazemier; Sybren Meijer; R Bleichrodt; Fred G van den Berg; HERBERT PINEDO; Giuseppe Giaccone
Hepatic arterial 5-fluorouracil in patients with liver metastases of colorectal cancer: single-centre experience in 145 patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(12):1563-70.
2000: Catharina J A Van Moorsel; HERBERT PINEDO; Kees Smid; Elizabeth M Comijn; Daphne Voorn; Gijsbert Veerman; B Lakerveld; Wim J F van der Vijgh; Giuseppe Giaccone; Pieter E Postmus; Godefridus J Peters
Schedule-dependent pharmacodynamic effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small cell lung tumours.
European journal of cancer (Oxford, England : 1990) 2000;36(18):2420-9.
2000: Cynthia Huisman; Egbert F Smit; Giuseppe Giaccone; Pieter E Postmus
Second-line chemotherapy in relapsing or refractory non-small-cell lung cancer: a review.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(21):3722-30.
2000: Jose Padron; Clasina L Van der Wilt; Kees Smid; E Smitskamp-Wilms; Harold H J Backus; P E Pizao; Giuseppe Giaccone; Godefridus J Peters
The multilayered postconfluent cell culture as a model for drug screening.
Critical reviews in oncology/hematology 2000;36(2-3):141-57.
2000: Jetske M Meerum Terwogt; Olaf van Tellingen; VR Nannan Panday; manon huizing; J H M Schellens; Wim W ten Bokkel Huinink; M U Boschma; Giuseppe Giaccone; Cindy Veenhof; Jos H Beijnen
Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients.
Anti-cancer drugs 2000;11(9):687-94.
2000: Pieter E Postmus; H Haaxma-Reiche; Egbert F Smit; Harry J M Groen; H Karnicka; T Lewinski; Jan P van Meerbeeck; M Clerico; Anna Gregor; Desmond Curran; TM Sahmoud; A Kirkpatrick; Giuseppe Giaccone
Treatment of brain metastases of small-cell lung cancer: comparing teniposide and teniposide with whole-brain radiotherapy--a phase III study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(19):3400-8.
2000: André Bergman; Giuseppe Giaccone; Catharina J A Van Moorsel; Robert Mauritz; Paul Noordhuis; HERBERT PINEDO; Godefridus J Peters
Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.
European journal of cancer (Oxford, England : 1990) 2000;36(15):1974-83.
2000: Judith R Kroep; Giuseppe Giaccone; C Tolis; Daphne Voorn; Willem J P Loves; C J Groeningen; HERBERT PINEDO; Godefridus J Peters
Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines.
British journal of cancer 2000;83(8):1069-76.
2000: AM Dingemans; J van Ark-Otte; Egbert F Smit; Pieter E Postmus; Giuseppe Giaccone
Validation of a polymerase chain reaction aided transcript titration assay (PATTY) for topoisomerase II in lung cancer samples.
Anticancer research 2000;20(5B):3549-54.
2000: Arnold Baars; A M E Claessen; Alfons J M van den Eertwegh; Helen Gall; Anita G M Stam; Sybren Meijer; Giuseppe Giaccone; Chris J L M Meijer; Rik J Scheper; John Wagstaff; Jan B Vermorken; HERBERT PINEDO
Skin tests predict survival after autologous tumor cell vaccination in metastatic melanoma: experience in 81 patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(8):965-70.
2000: J M G H van Riel; Cees J van Groeningen; Giuseppe Giaccone; HERBERT PINEDO
Hepatic arterial chemotherapy for colorectal cancer metastatic to the liver.
Oncology 2000;59(2):89-97.
2000: Cees J van Groeningen; Godefridus J Peters; Jan H Schornagel; Helen Gall; Paul Noordhuis; M J de Vries; S L Turner; M S Swart; HERBERT PINEDO; A R Hanauske; Giuseppe Giaccone
Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(14):2772-9.
2000: nico van zandwijk; Egbert F Smit; Gijsbert W P M Kramer; Franz Schramel; Steven Gans; Joost M Festen; A Termeer; N J Schlosser; Channa Debruyne; Desmond Curran; Giuseppe Giaccone
Gemcitabine and cisplatin as induction regimen for patients with biopsy-proven stage IIIA N2 non-small-cell lung cancer: a phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group (EORTC 08955).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(14):2658-64.
2000: Paul Baas; Jan P van Meerbeeck; H Groen; Hugo Schouwink; Sjaak A Burgers; S Daamen; Giuseppe Giaccone
Caelyx in malignant mesothelioma: a phase II EORTC study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(6):697-700.
2000: Ronald K Linskens; Richard P Golding; Cees J van Groeningen; Giuseppe Giaccone
Severe acute lung injury induced by gemcitabine.
The Netherlands journal of medicine 2000;56(6):232-5.
2000: Muhammed Hadithi; Marcel C Weijmer; J van den Bosch; Giuseppe Giaccone
A bone biopsy is mandatory in the optimal management of bone lesions in patients with a long-term history of malignancy of the breast.
The Netherlands journal of medicine 2000;56(6):223-8.
2000: B van Triest; HERBERT PINEDO; Giuseppe Giaccone; Godefridus J Peters
Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(4):385-91.
2000: Nobusuke Nishi; Hans J J van der Vliet; Yasuhiko Koezuka; B Mary E von Blomberg; Rik J Scheper; HERBERT PINEDO; Giuseppe Giaccone
Synergistic effect of KRN7000 with interleukin-15, -7, and -2 on the expansion of human V alpha 24+V beta 11+ T cells in vitro.
Human immunology 2000;61(4):357-65.
2000: Giuseppe Giaccone
Treatment of thymoma and thymic carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11 Suppl 3():245-6.
2000: Giuseppe Giaccone; Egbert F Smit; Jan P van Meerbeeck; Ted A W Splinter; Richard P Golding; HERBERT PINEDO; D Laan; Harm van Tinteren; Pieter E Postmus
A phase I-II study of gemcitabine and paclitaxel in advanced non-small-cell lung cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2000;11(1):109-12.
2000: Carlos G Ferreira; C Tolis; Simone W Span; Godefridus J Peters; T van Lopik; A J Kummer; HERBERT PINEDO; Giuseppe Giaccone
Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):203-12.
1999: Hans J J van der Vliet; Nobusuke Nishi; Yasuhiko Koezuka; Marie-Alix Peyrat; B Mary E von Blomberg; Alfons J M van den Eertwegh; HERBERT PINEDO; Giuseppe Giaccone; Rik J Scheper
Effects of alpha-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Valpha24+ Vbeta11+ T cells.
Immunology 1999;98(4):557-63.
1999: Carlos G Ferreira; C Tolis; Giuseppe Giaccone
p53 and chemosensitivity.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(9):1011-21.
1999: AM Dingemans; M Adhiambo Witlox; R A Stallaert; Paul Van Der Valk; Pieter E Postmus; Giuseppe Giaccone
Expression of DNA topoisomerase IIalpha and topoisomerase IIbeta genes predicts survival and response to chemotherapy in patients with small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2048-58.
1999: Cynthia Huisman; Pieter E Postmus; Giuseppe Giaccone; Egbert F Smit
Second-line chemotherapy and its evaluation in small cell lung cancer.
Cancer treatment reviews 1999;25(4):199-206.
1999: Judith R Kroep; Giuseppe Giaccone; Daphne Voorn; Egbert F Smit; Jos H Beijnen; H Rosing; Catharina J A Van Moorsel; Cees J van Groeningen; Pieter E Postmus; HERBERT PINEDO; Godefridus J Peters
Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(7):2190-7.
1999: Jan P van Meerbeeck; Paul Baas; Channa Debruyne; Harry J M Groen; Christian Manegold; Andrea Ardizzoni; C Gridelli; E A van Marck; M Lentz; Giuseppe Giaccone
A Phase II study of gemcitabine in patients with malignant pleural mesothelioma. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.
Cancer 1999;85(12):2577-82.
1999: C Tolis; Godefridus J Peters; Carlos G Ferreira; HERBERT PINEDO; Giuseppe Giaccone
Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines.
European journal of cancer (Oxford, England : 1990) 1999;35(5):796-807.
1999: Gert Jan Meersma; M Bakker; Harry J M Groen; Ate G J van der Zee; P B Jensen; Giuseppe Giaccone; Elisabeth G E de Vries; Egbert F Smit
A PCR-aided transcript titration assay (PATTY) to measure topoisomerase I gene expression in human tumor specimens.
Anticancer research 1999;19(2A):1309-15.
1999: Giuseppe Giaccone
Gemcitabine plus taxane combinations in non-small cell lung cancer.
Seminars in oncology 1999;26(1 Suppl 4):19-24.
1999: J M G H van Riel; Giuseppe Giaccone; HERBERT PINEDO
Pancreaticobiliary cancer: the future aspects of medical oncology.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():296-9.
1999: J M G H van Riel; Cees J van Groeningen; HERBERT PINEDO; Giuseppe Giaccone
Current chemotherapeutic possibilities in pancreaticobiliary cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10 Suppl 4():157-61.
1999: Aafke H Honkoop; Sylvia A Luykx-de Bakker; Klaas Hoekman; S Meyer; O W Meyer; Cees J van Groeningen; Paulus van Diest; Epie Boven; ELSKEN VAN DER WALL; Giuseppe Giaccone; John Wagstaff; HERBERT PINEDO
Prolonged neoadjuvant chemotherapy with GM-CSF in locally advanced breast cancer.
The oncologist 1999;4(2):106-11.
1998: Epie Boven; HERBERT PINEDO; Annemarie H Van Hattum; Peter G Scheffer; W H Peters; C A M Erkelens; Hennie M M Schlüper; CM Kuiper; J van Ark-Otte; Giuseppe Giaccone
Characterization of human soft-tissue sarcoma xenografts for use in secondary drug screening.
British journal of cancer 1998;78(12):1586-93.
1998: AM Dingemans; HERBERT PINEDO; Giuseppe Giaccone
Clinical resistance to topoisomerase-targeted drugs.
Biochimica et biophysica acta 1998;1400(1-3):275-88.
1998: Giuseppe Giaccone; C Manegold; R Rosell; U Gatzemeier; Elisabeth Quoix
An update on European randomized studies in non-small cell lung cancer.
Seminars in oncology 1998;25(4 Suppl 9):11-7.
1998: J van Ark-Otte; Marc A Kedde; Wim J F van der Vijgh; AM Dingemans; WJ Jansen; HERBERT PINEDO; Epie Boven; Giuseppe Giaccone
Determinants of CPT-11 and SN-38 activities in human lung cancer cells.
British journal of cancer 1998;77(12):2171-6.
1998: Giuseppe Giaccone; Ted A W Splinter; Channa Debruyne; G S Kho; Pilar Lianes; nico van zandwijk; M C Pennucci; Giorgio V Scagliotti; Jan P van Meerbeeck; Q van Hoesel; Desmond Curran; TM Sahmoud; Pieter E Postmus
Randomized study of paclitaxel-cisplatin versus cisplatin-teniposide in patients with advanced non-small-cell lung cancer. The European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(6):2133-41.
1998: Aafke H Honkoop; Paulus van Diest; JS De Jong; SC Linn; Giuseppe Giaccone; Klaas Hoekman; John Wagstaff; HERBERT PINEDO
Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer.
British journal of cancer 1998;77(4):621-6.
1998: VR Nannan Panday; LJ van Warmerdam; manon huizing; Wim W ten Bokkel Huinink; Jan B Vermorken; Giuseppe Giaccone; Cindy Veenhof; J H M Schellens; Jos H Beijnen
Carboplatin dosage formulae can generate inaccurate predictions of Carboplatin exposure in carboplatin/paclitaxel combination regimens.
Clinical drug investigation 1998;15(4):327-35.
1998: WJ Jansen; Theresia M Hulscher; J van Ark-Otte; Giuseppe Giaccone; HERBERT PINEDO; Epie Boven
CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated protein.
British journal of cancer 1998;77(3):359-65.
1998: J van Ark-Otte; G Samelis; G Rubio; J B Lopez Saez; HERBERT PINEDO; Giuseppe Giaccone
Effects of tubulin-inhibiting agents in human lung and breast cancer cell lines with different multidrug resistance phenotypes.
Oncology reports 1998;5(1):249-55.
1997: Giuseppe Giaccone; SC Linn; J Welink; G Catimel; H Stieltjes; Wim J F van der Vijgh; CM Eeltink; Jan B Vermorken; HERBERT PINEDO
A dose-finding and pharmacokinetic study of reversal of multidrug resistance with SDZ PSC 833 in combination with doxorubicin in patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2005-15.
1997: TM Sahmoud; Pieter E Postmus; C van Pottelsberghe; Karin Mattson; Lauri Tammilehto; Ted A W Splinter; A S T Planting; Tom G Sutedja; J van Pawel; nico van zandwijk; Paul Baas; K J Roozendaal; M Schrijver; A Kirkpatrick; M Van Glabbeke; Andrea Ardizzoni; Giuseppe Giaccone
Etoposide in malignant pleural mesothelioma: two phase II trials of the EORTC Lung Cancer Cooperative Group.
European journal of cancer (Oxford, England : 1990) 1997;33(13):2211-5.
1997: nico van zandwijk; Harry J M Groen; Pieter E Postmus; Jos Burghouts; G P ten Velde; Andrea Ardizzoni; I E Smith; Paul Baas; TM Sahmoud; A Kirkpatrick; Otilia Dalesio; Giuseppe Giaccone
Role of recombinant interferon-gamma maintenance in responding patients with small cell lung cancer. A randomised phase III study of the EORTC Lung Cancer Cooperative Group.
European journal of cancer (Oxford, England : 1990) 1997;33(11):1759-66.
1997: Aafke H Honkoop; ELSKEN VAN DER WALL; Nicole Feller; Gerrit J Schuurhuis; Wim J F van der Vijgh; Epie Boven; Cees J van Groeningen; Giuseppe Giaccone; Klaas Hoekman; Jan B Vermorken; John Wagstaff; HERBERT PINEDO
Multiple cycles of high-dose doxorubicin and cyclophosphamide with G-CSF mobilized peripheral blood progenitor cell support in patients with metastatic breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8(10):957-62.
1997: AM Dingemans; Ruud H Brakenhoff; Pieter E Postmus; Giuseppe Giaccone
Detection of cytokeratin-19 transcripts by reverse transcriptase-polymerase chain reaction in lung cancer cell lines and blood of lung cancer patients.
Laboratory investigation; a journal of technical methods and pathology 1997;77(3):213-20.
1997: Anna Gregor; P Drings; Jos Burghouts; Pieter E Postmus; D Morgan; TM Sahmoud; A Kirkpatrick; Otilia Dalesio; Giuseppe Giaccone
Randomized trial of alternating versus sequential radiotherapy/chemotherapy in limited-disease patients with small-cell lung cancer: a European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(8):2840-9.
1997: R M Apolinario; Paul Van Der Valk; JS De Jong; W Deville; J van Ark-Otte; AM Dingemans; Johan C van Mourik; Pieter E Postmus; HERBERT PINEDO; Giuseppe Giaccone
Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(6):2456-66.
1997: SC Linn; HERBERT PINEDO; J van Ark-Otte; P van der Valk; Klaas Hoekman; Aafke H Honkoop; Jan B Vermorken; Giuseppe Giaccone
Expression of drug resistance proteins in breast cancer, in relation to chemotherapy.
International journal of cancer. Journal international du cancer 1997;71(5):787-95.
1997: Giuseppe Giaccone; Pieter E Postmus; Ted A W Splinter; M Diaz-Puente; nico van zandwijk; Giorgio V Scagliotti; Andrea Ardizzoni; Jan P van Meerbeeck; Channa Debruyne
Cisplatin/paclitaxel vs cisplatin/teniposide for advanced non-small-cell lung cancer. The EORTC Lung Cancer Cooperative Group. The European Organization for Research and Treatment of Cancer.
Oncology (Williston Park, N.Y.) 1997;11(4 Suppl 3):11-4.
1997: WJ Jansen; B Zwart; S T Hulscher; Giuseppe Giaccone; HERBERT PINEDO; Epie Boven
CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants.
International journal of cancer. Journal international du cancer 1997;70(3):335-40.
1996: Pieter E Postmus; Giuseppe Giaccone; Channa Debruyne; TM Sahmoud; Ted A W Splinter; nico van zandwijk
Results of the phase II EORTC study comparing paclitaxel/cisplatin with teniposide/cisplatin in patients with non-small cell lung cancer. EORTC Lung Cancer Cooperative Group.
Seminars in oncology 1996;23(5 Suppl 12):10-3.
1996: Jan P van Meerbeeck; Channa Debruyne; nico van zandwijk; Pieter E Postmus; M C Pennucci; F van Breukelen; D Galdermans; H Groen; P Pinson; M van Glabbeke; Eric Van Marck; Giuseppe Giaccone
Paclitaxel for malignant pleural mesothelioma: a phase II study of the EORTC Lung Cancer Cooperative Group.
British journal of cancer 1996;74(6):961-3.
1996: Pieter E Postmus; Giorgio V Scagliotti; H J Groen; F Gozzelino; J T Burghouts; Desmond Curran; TM Sahmoud; A Kirkpatrick; Giuseppe Giaccone; Ted A W Splinter
Standard versus alternating non-cross-resistant chemotherapy in extensive small cell lung cancer: an EORTC Phase III trial.
European journal of cancer (Oxford, England : 1990) 1996;32A(9):1498-503.
1996: AM Dingemans; J van Ark-Otte; Paul Van Der Valk; R M Apolinario; Rik J Scheper; Pieter E Postmus; Giuseppe Giaccone
Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7(6):625-30.
1996: SC Linn; Aafke H Honkoop; Klaas Hoekman; Paul Van Der Valk; HERBERT PINEDO; Giuseppe Giaccone
p53 and P-glycoprotein are often co-expressed and are associated with poor prognosis in breast cancer.
British journal of cancer 1996;74(1):63-8.
1996: Giuseppe Giaccone; J van Ark-Otte; G J Rubio; A F Gazdar; Henk J Broxterman; AM Dingemans; Marcel J Flens; Rik J Scheper; HERBERT PINEDO
MRP is frequently expressed in human lung-cancer cell lines, in non-small-cell lung cancer and in normal lungs.
International journal of cancer. Journal international du cancer 1996;66(6):760-7.
1996: Giuseppe Giaccone
New drugs for the management of lung cancer.
British journal of hospital medicine 1996;55(10):634-8.
1996: Miguel A Izquierdo; George L Scheffer; Marcel J Flens; Giuseppe Giaccone; Henk J Broxterman; Chris J L M Meijer; Paul Van Der Valk; Rik J Scheper
Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.
The American journal of pathology 1996;148(3):877-87.
1996: nico van zandwijk; Giuseppe Giaccone
Treatment of metastatic non-small cell lung cancer.
Current opinion in oncology 1996;8(2):120-5.
1996: Giuseppe Giaccone; Andrea Ardizzoni; A Kirkpatrick; M Clerico; TM Sahmoud; nico van zandwijk
Cisplatin and etoposide combination chemotherapy for locally advanced or metastatic thymoma. A phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(3):814-20.
1996: A S T Planting; P Helle; P Drings; Otilia Dalesio; A Kirkpatrick; G McVie; Giuseppe Giaccone
A randomized study of high-dose split course radiotherapy preceded by high-dose chemotherapy versus high-dose radiotherapy only in locally advanced non-small-cell lung cancer. An EORTC Lung Cancer Cooperative Group trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7(2):139-44.
1996: Aafke H Honkoop; Klaas Hoekman; John Wagstaff; Epie Boven; Cees J van Groeningen; Giuseppe Giaccone; Jan B Vermorken; HERBERT PINEDO
Dose-intensive chemotherapy with doxorubicin, cyclophosphamide and GM-CSF fails to improve survival of metastatic breast cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7(1):35-9.
1996: Ted A W Splinter; TM Sahmoud; J Festen; nico van zandwijk; S Sörenson; M Clerico; J Burghouts; B Dautzenberg; G S Kho; A Kirkpatrick; Giuseppe Giaccone
Two schedules of teniposide with or without cisplatin in advanced non-small-cell lung cancer: a randomized study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(1):127-34.
1995: Giuseppe Giaccone; J van Ark-Otte; Giorgio V Scagliotti; G Capranico; Paul Van Der Valk; G Rubio; O Dalesio; R Lopez; F Zunino; J Walboomers
Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung.
Biochimica et biophysica acta 1995;1264(3):337-46.
1995: Miguel A Izquierdo; Paul Van Der Valk; J van Ark-Otte; G Rubio; J R Germa-Lluch; R Ueda; Rik J Scheper; T Takahashi; Giuseppe Giaccone
Differential expression of the c-kit proto-oncogene in germ cell tumours.
The Journal of pathology 1995;177(3):253-8.
1995: Henk J Broxterman; Giuseppe Giaccone; Jan Lankelma
Multidrug resistance proteins and other drug transport-related resistance to natural product agents.
Current opinion in oncology 1995;7(6):532-40.
1995: E Smitskamp-Wilms; Giuseppe Giaccone; HERBERT PINEDO; B F van der Laan; Godefridus J Peters
DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
British journal of cancer 1995;72(4):917-21.
1995: S C Linn; Giuseppe Giaccone; Paulus van Diest; W M Blokhuis; Paul Van Der Valk; C K van Kalken; CM Kuiper; HERBERT PINEDO; Jan P A Baak
Prognostic relevance of P-glycoprotein expression in breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(7):679-85.
1995: Miguel A Izquierdo; Ate G J van der Zee; J B Vermorken; Paul Van Der Valk; Jeroen A M Beliën; Giuseppe Giaccone; George L Scheffer; Marcel J Flens; HERBERT PINEDO; P Kenemans
Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma.
Journal of the National Cancer Institute 1995;87(16):1230-7.
1995: Giuseppe Giaccone; manon huizing; P E Postmus; Wim W ten Bokkel Huinink; M Koolen; nico van zandwijk; Jan B Vermorken; Jos H Beijnen; Otilia Dalesio; HERBERT PINEDO
Dose-finding and sequencing study of paclitaxel and carboplatin in non-small cell lung cancer.
Seminars in oncology 1995;22(4 Suppl 9):78-82.
1995: S C Linn; Giuseppe Giaccone
MDR1/P-glycoprotein expression in colorectal cancer.
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1291-4.
1995: Giuseppe Giaccone
New drugs in non-small cell lung cancer. An overview.
Lung cancer (Amsterdam, Netherlands) 1995;12 Suppl 1():S155-62.
1995: Giuseppe Giaccone; S C Linn; HERBERT PINEDO
Multidrug resistance in breast cancer: mechanisms, strategies.
European journal of cancer (Oxford, England : 1990) 1995;31A Suppl 7():S15-7.
1995: G J Rubio; HERBERT PINEDO; J Virizuela; J van Ark-Otte; Giuseppe Giaccone
Effects of suramin on human lung cancer cell lines.
European journal of cancer (Oxford, England : 1990) 1995;31A(2):244-51.
1994: Jos H Beijnen; manon huizing; Wim W ten Bokkel Huinink; Cindy Veenhof; Jan B Vermorken; Giuseppe Giaccone; HERBERT PINEDO
Bioanalysis, pharmacokinetics, and pharmacodynamics of the novel anticancer drug paclitaxel (Taxol).
Seminars in oncology 1994;21(5 Suppl 8):53-62.
1994: Giuseppe Giaccone; manon huizing; Wim W ten Bokkel Huinink; M Koolen; P Postmus; K van Kralingen; nico van zandwijk; Jan B Vermorken; Jos H Beijnen; Otilia Dalesio
Preliminary results of two dose-finding studies of paclitaxel (Taxol) and carboplatin in non-small cell lung and ovarian cancers: a European Cancer Centre effort.
Seminars in oncology 1994;21(5 Suppl 8):34-8.
1994: P E Pizao; E Smitskamp-Wilms; J van Ark-Otte; Jos H Beijnen; Godefridus J Peters; HERBERT PINEDO; Giuseppe Giaccone
Antiproliferative activity of the topoisomerase I inhibitors topotecan and camptothecin, on sub- and postconfluent tumor cell cultures.
Biochemical pharmacology 1994;48(6):1145-54.
1994: E Smitskamp-Wilms; Godefridus J Peters; HERBERT PINEDO; J van Ark-Otte; Giuseppe Giaccone
Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression.
Biochemical pharmacology 1994;47(8):1325-32.
1994: S C Linn; C K van Kalken; O van Tellingen; Paul Van Der Valk; Cees J van Groeningen; CM Kuiper; HERBERT PINEDO; Giuseppe Giaccone
Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(4):812-9.
1994: Giuseppe Giaccone
DNA topoisomerases and topoisomerase inhibitors.
Pathologie-biologie 1994;42(4):346-52.
1994: Giuseppe Giaccone
Small cell lung cancer and topoisomerases.
Anticancer research 1994;14(1B):269-76.
1994: R Lopez; Godefridus J Peters; E Smitskamp-Wilms; J A Virizuela; J van Ark-Otte; HERBERT PINEDO; Giuseppe Giaccone
In vitro sequence-dependent synergistic effect of suramin and camptothecin.
European journal of cancer (Oxford, England : 1990) 1994;30A(11):1670-4.
1993: Giuseppe Giaccone; O Dalesio; G J McVie; A Kirkpatrick; Pieter E Postmus; J T Burghouts; W Bakker; M G Koolen; C P Vendrik; K J Roozendaal
Maintenance chemotherapy in small-cell lung cancer: long-term results of a randomized trial. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(7):1230-40.
1993: M Clerico; Oscar Bertetto; M P Morandini; C Cardinali; Giuseppe Giaccone
Antiemetic activity of oral lorazepam in addition to methylprednisolone and metoclopramide in the prophylactic treatment of vomiting induced by cisplatin. A double-blind, placebo-controlled study with crossover design.
Tumori 1993;79(2):119-22.
1993: C K van Kalken; Henk J Broxterman; HERBERT PINEDO; Nicole Feller; H Dekker; Jan Lankelma; Giuseppe Giaccone
Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
British journal of cancer 1993;67(2):284-9.
1993: P E Pizao; Godefridus J Peters; J van Ark-Otte; L A Smets; E Smitskamp-Wilms; B Winograd; HERBERT PINEDO; Giuseppe Giaccone
Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures.
European journal of cancer (Oxford, England : 1990) 1993;29A(11):1566-73.
1992: C K van Kalken; Giuseppe Giaccone; Paul Van Der Valk; CM Kuiper; M M Hadisaputro; S A Bosma; Rik J Scheper; C J Meijer; HERBERT PINEDO
Multidrug resistance gene (P-glycoprotein) expression in the human fetus.
The American journal of pathology 1992;141(5):1063-72.
1992: P E Pizao; D M Lyaruu; Godefridus J Peters; J van Ark-Otte; B Winograd; Giuseppe Giaccone; HERBERT PINEDO
Growth, morphology and chemosensitivity studies on postconfluent cells cultured in 'V'-bottomed microtiter plates.
British journal of cancer 1992;66(4):660-5.
1992: P E Pizao; B Winograd; Godefridus J Peters; A Leyva; Giuseppe Giaccone; HERBERT PINEDO
In vitro chemosensitivity testing of multilayered microcultures.
Anticancer research 1992;12(4):1319-22.
1992: K Mattson; Giuseppe Giaccone; A Kirkpatrick; D Evrard; L Tammilehto; F J van Breukelen; H T Planteydt; nico van zandwijk
Epirubicin in malignant mesothelioma: a phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(5):824-8.
1992: Giuseppe Giaccone; T A Splinter; A Kirkpatrick; O Dalesio; nico van zandwijk; J G McVie
The European Organization for Research and Treatment of Cancer experience with teniposide: preliminary results of a randomized study in non-small cell lung cancer.
Seminars in oncology 1992;19(2 Suppl 6):98-102.
1992: Giuseppe Giaccone
Teniposide alone and in combination chemotherapy in small cell lung cancer.
Seminars in oncology 1992;19(2 Suppl 6):75-80.
1992: Elisabeth Quoix; Giuseppe Giaccone; Jacek Jassem; H Karnicka; Elzbieta Wiatr; H Cortes-Funes; K J Roozendaal; A Kirkpatrick; D Evrard; nico van zandwijk
Epirubicin in previously untreated patients with small cell lung cancer: a phase II study by the EORTC Lung Cancer Cooperative Group.
European journal of cancer (Oxford, England : 1990) 1992;28A(10):1667-70.
1991: Giuseppe Giaccone; G Schmidt; A Calciati
Pilot study of teniposide in combination chemotherapy for small cell lung cancer.
European journal of cancer (Oxford, England : 1990) 1991;27(2):141-3.
1991: C K van Kalken; J J van der Hoeven; J de Jong; Giuseppe Giaccone; Gerrit J Schuurhuis; P A Maessen; W M Blokhuis; W J van der Vijgh; HERBERT PINEDO
Bepridil in combination with anthracyclines to reverse anthracycline resistance in cancer patients.
European journal of cancer (Oxford, England : 1990) 1991;27(6):739-44.
1991: F J van Breukelen; K Mattson; Giuseppe Giaccone; nico van zandwijk; H T Planteydt; A Kirkpatrick; Otilia Dalesio
Mitoxantrone in malignant pleural mesothelioma: a study by the EORTC Lung Cancer Cooperative Group.
European journal of cancer (Oxford, England : 1990) 1991;27(12):1627-9.
1991: C K van Kalken; HERBERT PINEDO; Giuseppe Giaccone
Multidrug resistance from the clinical point of view.
European journal of cancer (Oxford, England : 1990) 1991;27(11):1481-6.
1991: V Iberti; M Donadio; Giuseppe Giaccone
Cisplatin and teniposide chemotherapy for advanced non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990) 1991;27(9):1104-6.
1991: Giuseppe Giaccone; V Iberti; M Donadio; F Testore
Mitomycin C, teniposide, and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung.
Cancer chemotherapy and pharmacology 1991;28(2):147-9.
1990: Giuseppe Giaccone; M Donadio; G Bonardi; V Iberti; A Calciati
4'-EPI-doxorubicin in advanced lung cancer. A phase II trial.
Investigational new drugs 1990;8(4):393-6.
1990: Giuseppe Giaccone; M Donadio; G Bonardi; F Testore; A Calciati
Doxorubicin and etoposide in the treatment of advanced measurable breast cancer.
Oncology 1990;47(2):105-8.
1989: Giuseppe Giaccone; M Bagatella; M Donadio; A Calciati
Phase II study of divided-dose vinblastine in advanced cancer patients.
Tumori 1989;75(3):248-51.
1989: G Anderson; M Clavel; J Smyth; Giuseppe Giaccone; M Gracia; A S T Planting; O Dalesio; A Kirkpatrick; G McVie
Phase II study of 9-hydroxy-2-methyl-ellipticinium acetate (ellipticinium) in patients with advanced carcinoma of the lung. EORTC Lung Cancer Cooperative Group.
European journal of cancer & clinical oncology 1989;25(5):909-10.
1989: G Bonardi; M Donadio; F Maestroni; Giuseppe Giaccone; A Calciati
Isolated central nervous system metastasis from ovarian carcinoma: a case report.
Tumori 1989;75(2):181-2.
1989: Giuseppe Giaccone
Identification of new drugs in pretreated patients with small cell lung cancer.
European journal of cancer & clinical oncology 1989;25(3):411-3.
1989: Giuseppe Giaccone; M Donadio; G Bonardi; L Silvestro; Ilario Viano; G Cotevino; M Vinzio; E Genazzani; A Calciati
Phase II study of alpha-interferon plus bleomycin in advanced non-small cell lung cancer.
Anticancer research 1989;9(2):405-8.
1989: Giuseppe Giaccone; M Bagatella; M Donadio; G Bonardi; F Maestroni; A Calciati
Lonidamine versus polychemotherapy in advanced non-small-cell lung cancer. A preliminary analysis.
Tumori 1989;75(1):43-6.
1989: Giuseppe Giaccone; M Donadio; A Calciati
Phase II study of esorubicin in the treatment of patients with advanced sarcoma.
Oncology 1989;46(5):285-7.
1988: Giuseppe Giaccone; M Donadio; G Bonardi; F Testore; A Calciati
Teniposide in the treatment of small-cell lung cancer: the influence of prior chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(8):1264-70.
1988: Giuseppe Giaccone; M Donadio; P Ferrati; A Calciati
Cisplatin and etoposide in chemotherapy-refractory advanced breast cancer.
Tumori 1988;74(2):191-3.
1988: Giuseppe Giaccone; M Donadio; G M Bonardi; F Testore; A Calciati
Teniposide (VM26): an effective treatment for brain metastases of small cell carcinoma of the lung.
European journal of cancer & clinical oncology 1988;24(4):629-31.
1988: Giuseppe Giaccone; Oscar Bertetto; M A Secat; A Calciati
High doses of methylprednisolone with or without alizapride in the prevention of cisplatin-induced emesis. A randomized, double-blind, crossover study.
Oncology 1988;45(2):74-8.
1988: Giuseppe Giaccone; M Bagatella; Oscar Bertetto; M Donadio; A Calciati
Phase II study of divided-dose vinblastine in advanced breast cancer patients.
Cancer chemotherapy and pharmacology 1988;21(1):65-7.
1987: Giuseppe Giaccone; P Ferrati; M Donadio; F Testore; A Calciati
Reinduction chemotherapy in small cell lung cancer.
European journal of cancer & clinical oncology 1987;23(11):1697-9.
1987: Giuseppe Giaccone; M Bagatella; M Donadio; G M Bonardi; F Testore; P Ferrati; L Ciuffreda; A Calciati
Mitomycin C, vinblastine and cis-platin. An active regimen for advanced non-small cell lung cancer.
British journal of cancer 1987;56(4):475-8.
1987: Giuseppe Giaccone; M Donadio; G Bonardi; M Bagatella; A Calciati
4'-Deoxydoxorubicin, an inactive drug in small cell lung cancer.
European journal of cancer & clinical oncology 1987;23(9):1407-8.
1987: Giuseppe Giaccone; M Donadio; P Ferrati; G Bonardi; L Ciuffreda; M Bagatella; A Calciati
Teniposide in the treatment of non-small cell lung carcinoma.
Cancer treatment reports 1987;71(1):83-5.
1987: Giuseppe Giaccone; L Ciuffreda; M Donadio; P Ferrati; M Risio; G Leria; G Bonardi; A Calciati
Bone marrow evaluation in small cell carcinoma of the lung.
Acta oncologica (Stockholm, Sweden) 1987;26(3):185-8.
1986: Giuseppe Giaccone; G Bonardi; G Leria; M Donadio; A Calciati
Long-term survival and complete response to adriamycin and etoposide in a case of hepatocellular carcinoma.
Tumori 1986;72(4):409-11.
1986: G Maggi; Giuseppe Giaccone; M Donadio; L Ciuffreda; O Dalesio; G Leria; G Trifiletti; C Casadio; G Palestro; M Mancuso
Thymomas. A review of 169 cases, with particular reference to results of surgical treatment.
Cancer 1986;58(3):765-76.
1986: Giuseppe Giaccone; M Risio; G Bonardi; A Calciati
Stevens-Johnson syndrome and fatal pulmonary toxicity to combination chemotherapy containing bleomycin: a case report.
Tumori 1986;72(3):331-3.
1985: Giuseppe Giaccone; R Musella; Oscar Bertetto; M Donadio; A Calciati
Cisplatin-containing chemotherapy in the treatment of invasive thymoma: report of five cases.
Cancer treatment reports 1985;69(6):695-7.
1985: Giuseppe Giaccone; M Donadio; P Ferrati; L Ciuffreda; M Bagatella; M Gaddi; A Calciati
Disorders of serum electrolytes and renal function in patients treated with cis-platinum on an outpatient basis.
European journal of cancer & clinical oncology 1985;21(4):433-7.
1984: Giuseppe Giaccone; M Donadio; R Musella; Oscar Bertetto; L Ciuffreda; P Ferrati; M Clerico; A Calciati
Comparison of methylprednisolone and metoclopramide in the prophylactic treatment of cis-platin-induced nausea and vomiting.
Tumori 1984;70(3):237-41.
1983: R Musella; Giuseppe Giaccone; E D'Ambrosio; A Calciati
Father-son testicular cancer, case report.
Tumori 1983;69(3):269-70.
1981: P F Conte; Giuseppe Giaccone; R Musella; A Calciati
Combination chemotherapy for metastatic brain tumors.
Tumori 1981;67(6):559-62.