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Diego Arango

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Rocco Mazzolini; Mark S Mooseker; Santiago Ramón y Cajal; Jaume Reventós; Paulo Rodrigues; Simo Schwartz; Hiromu Suzuki; Stefan M Woerner; Hiroyuki Yamamoto; Sarah Bazzocco; Higinio Dopeso; Ana M Ferreira; Johannes Gebert; Javier Hernandez Losa; Robert M W Hofstra; Stefania Landolfi; Irati Macaya; John M Mariadason; Silvia Mateo-Lozano; Hafid Alazzouzi; Elena Andretta; Diego Arango
Brush border myosin Ia inactivation in gastric but not endometrial tumors.
Verónica Dávalos; Eloi Espín; Yolanda Fernandez; Angel Guerra-Moreno; Anthea Messent; Eva Musulen; Joan Sayós; Ibane Abasolo; Diego Arango; Aurelio Ariza; Manel Armengol; Julio Castaño; Lucía Súarez-López; Simó Schwartz
Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.
Diego Arango; Do-Sun Byun; Azadeh A Carr; Georgia Corner; Higinio Dopeso; Barry Iacopetta; Rocco Mazzolini; Carmel Murone; Lars Tögel; David S Williams; Nikolajs Zeps; Lauri A Aaltonen; Sheren Al-Obaidi; John M Mariadason
Villin expression is frequently lost in poorly differentiated colon cancer.

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All Publications

2013: Rocco Mazzolini; Mark S Mooseker; Santiago Ramón y Cajal; Jaume Reventós; Paulo Rodrigues; Simo Schwartz; Hiromu Suzuki; Stefan M Woerner; Hiroyuki Yamamoto; Sarah Bazzocco; Higinio Dopeso; Ana M Ferreira; Johannes Gebert; Javier Hernandez Losa; Robert M W Hofstra; Stefania Landolfi; Irati Macaya; John M Mariadason; Silvia Mateo-Lozano; Hafid Alazzouzi; Elena Andretta; Diego Arango
Brush border myosin Ia inactivation in gastric but not endometrial tumors.
International journal of cancer. Journal international du cancer 2013;132(8):1790-9.
2012: Verónica Dávalos; Eloi Espín; Yolanda Fernandez; Angel Guerra-Moreno; Anthea Messent; Eva Musulen; Joan Sayós; Ibane Abasolo; Diego Arango; Aurelio Ariza; Manel Armengol; Julio Castaño; Lucía Súarez-López; Simó Schwartz
Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.
The Journal of biological chemistry 2012;287(52):43472-81.
2012: Diego Arango; Do-Sun Byun; Azadeh A Carr; Georgia Corner; Higinio Dopeso; Barry Iacopetta; Rocco Mazzolini; Carmel Murone; Lars Tögel; David S Williams; Nikolajs Zeps; Lauri A Aaltonen; Sheren Al-Obaidi; John M Mariadason
Villin expression is frequently lost in poorly differentiated colon cancer.
The American journal of pathology 2012;180(4):1509-21.
2012: Pia Alhopuro; Diego Arango; Mia Biström; Ana M Ferreira; Sampsa Hautaniemi; Elina Heliövaara; Robert M W Hofstra; Heikki Järvinen; Auli Karhu; Heli J Lehtonen; Jukka-Pekka Mecklin; Iina Niittymäki; Kari Nousiainen; Torben F Orntoft; Jani Puhakka; Anniina Raitila; Ari Ristimäki; Juha Saharinen; Heli Sammalkorpi; Raquel Seruca; Sónia Sousa; Sari Tuupanen; Lauri A Aaltonen
Candidate driver genes in microsatellite-unstable colorectal cancer.
International journal of cancer. Journal international du cancer 2012;130(7):1558-66.
2012: Rocco Mazzolini; Mark S Mooseker; Santiago Ramón y Cajal; Paulo Rodrigues; Simo Schwartz; Josep Tabernero; Lauri A Aaltonen; Hafid Alazzouzi; Pia Alhopuro; Elena Andretta; Manel Armengol; Sarah Bazzocco; Wakam Chang; Higinio Dopeso; Eloy Espín; Johannes Gebert; Javier Hernandez Losa; Matthias Kloor; Stefania Landolfi; John M Mariadason; Silvia Mateo-Lozano; Diego Arango
Brush border myosin Ia has tumor suppressor activity in the intestine.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):1530-5.
2010: Pia Alhopuro; Mikael Björklund; Heli Sammalkorpi; Mikko Turunen; Sari Tuupanen; Mia Biström; Iina Niittymäki; Heli J Lehtonen; Teemu Kivioja; Virpi Launonen; Juha Saharinen; Kari Nousiainen; Sampsa Hautaniemi; Kyösti Nuorva; Jukka-Pekka Mecklin; Heikki Järvinen; Torben F Orntoft; Diego Arango; Rainer Lehtonen; Auli Karhu; Jussi Taipale; Lauri A Aaltonen
Mutations in the circadian gene CLOCK in colorectal cancer.
Molecular cancer research : MCR 2010;8(7):952-60.
2010: Higinio Dopeso; Silvia Mateo-Lozano; Elena Elez; Stefania Landolfi; Francisco Javier Ramos Pascual; Javier Hernandez Losa; Rocco Mazzolini; Paulo Rodrigues; Sarah Bazzocco; Maria Josep Carreras; Eloi Espín; Manel Armengol; Andrew J Wilson; John M Mariadason; Santiago Ramon Y Cajal; Josep Tabernero; Simo Schwartz; Diego Arango
Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(8):2375-82.
2010: Andrew J Wilson; Anderly Chueh; Lars Tögel; Georgia A Corner; Naseem Ahmed; SANJAY GOEL; Do-Sun Byun; Shannon Nasser; Michele A Houston; Minaxi Jhawer; Helena J M Smartt; Lucas B Murray; Courtney Nicholas; Barbara G Heerdt; Diego Arango; Leonard H Augenlicht; John M Mariadason
Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.
Cancer research 2010;70(2):609-20.
2009: Ziqiang Yuan; Joongho Shin; Andrew J Wilson; SANJAY GOEL; Yi-He Ling; Naseem Ahmed; Higinio Dopeso; Minaxi Jhawer; Shannon Nasser; Cristina Montagna; Kenneth Fordyce; Leonard H Augenlicht; Lauri A Aaltonen; Diego Arango; Thomas K. Weber; John M Mariadason
An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.
Cancer research 2009;69(19):7811-8.
2008: Andrew J Wilson; Do-Sun Byun; Shannon Nasser; Lucas B Murray; Kanyalakshmi Ayyanar; Diego Arango; Maria Figueroa; Ari Melnick; Gary D Kao; Leonard H Augenlicht; John M Mariadason
HDAC4 promotes growth of colon cancer cells via repression of p21.
Molecular biology of the cell 2008;19(10):4062-75.
2008: Santiago Ropero; Esteban Ballestar; Miguel Alaminos; Diego Arango; Simó Schwartz; Manel Esteller
Transforming pathways unleashed by a HDAC2 mutation in human cancer.
Oncogene 2008;27(28):4008-12.
2008: Pia Alhopuro; Denis Phichith; Sari Tuupanen; Heli Sammalkorpi; Miranda Nybondas; Juha Saharinen; James P Robinson; Zhaohui Yang; Li-Qiong Chen; Torben Orntoft; Jukka-Pekka Mecklin; Heikki Järvinen; Charis Eng; Gabriela Moeslein; Darryl Shibata; richard Houlston; Anneke Lucassen; Ian P M Tomlinson; Virpi Launonen; Ari Ristimäki; Diego Arango; Auli Karhu; H Lee Sweeney; Lauri A Aaltonen
Unregulated smooth-muscle myosin in human intestinal neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5513-8.
2008: Minaxi Jhawer; SANJAY GOEL; Andrew J Wilson; Cristina Montagna; Yi-He Ling; Do-Sun Byun; Shannon Nasser; Diego Arango; Joongho Shin; Lidija Klampfer; Leonard H Augenlicht; Roman Perez-Soler; Roman Perez Soler; John M Mariadason
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.
Cancer research 2008;68(6):1953-61.
2008: Jordi Romero-Giménez; Higinio Dopeso; Ignacio Blanco; Angel Guerra-Moreno; Sara Gonzalez; Stefanie Vogt; Stefan Aretz; Simo Schwartz; Gabriel Capella; Diego Arango
Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families.
International journal of cancer. Journal international du cancer 2008;122(6):1422-5.
2007: Päivi Laiho; Antti Kokko; Sakari Vanharanta; Reijo Salovaara; Heli Sammalkorpi; Heikki Järvinen; Jukka-Pekka Mecklin; Tuomo J Karttunen; Karoliina Tuppurainen; Veronica Davalos; Simó Schwartz; Diego Arango; Markus Makinen; Lauri A Aaltonen
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.
Oncogene 2007;26(2):312-20.
2007: Veronica Davalos; H Dopeso; Sérgia Velho; A M Ferreira; Luís Cirnes; N Díaz-Chico; Cristina Bilbao; R Ramírez; G Rodríguez; Orlando Falcón; L León; Renée C Niessen; Gisela Keller; G Dallenbach-Hellweg; Eloi Espín; Manel Armengol; Alberto Plaja; Manuel Perucho; Kohzoh Imai; Hiroyuki Yamamoto; Johannes Gebert; Juan C Díaz-Chico; Robert M W Hofstra; Stefan M Woerner; Raquel Seruca; Simó Schwartz; Diego Arango
High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability.
Oncogene 2007;26(2):308-11.
2007: Hafid Alazzouzi; Gianpaolo Suriano; Angel Guerra; Alberto Plaja; Eloi Espín; Manel Armengol; Pia Alhopuro; Sergia Velho; Yasuhisa Shinomura; Juan José González-Aguilera; Hiroyuki Yamamoto; Lauri A Aaltonen; Victor Moreno; Gabriel Capellà; Miguel Angel Peinado; Raquel Seruca; Diego Arango; Simó Schwartz
Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells.
Journal of medical genetics 2007;44(1):75-80.
2006: Veronica Davalos; Higinio Dopeso; Julio Castaño; Andrew J Wilson; Felip Vilardell; Jordi Romero-Gimenez; Eloi Espín; Manel Armengol; Gabriel Capella; John M Mariadason; Lauri A Aaltonen; Simo Schwartz; Diego Arango
EPHB4 and survival of colorectal cancer patients.
Cancer research 2006;66(18):8943-8.
2006: Andrew J Wilson; Do-Sun Byun; Natalia Popova; Lucas B Murray; Kaitlin L'Italien; Yoshihiro Sowa; Diego Arango; Anna Velcich; Leonard H Augenlicht; John M Mariadason
Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer.
The Journal of biological chemistry 2006;281(19):13548-58.
2006: Viktoriya Paroder; Shelly R Spencer; Monika Paroder; Diego Arango; Simo Schwartz; John M Mariadason; Leonard H Augenlicht; Sepehr Eskandari; Nancy Carrasco
Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7270-5.
2006: Santiago Ropero; Mario F Fraga; Esteban Ballestar; Richard Hamelin; Hiroyuki Yamamoto; Manuel Boix-Chornet; Rosalia Caballero; Miguel Alaminos; Fernando Setien; Maria Fe Paz; Michel Herranz; José Palacios; Diego Arango; Torben F Orntoft; Lauri A Aaltonen; Simó Schwartz; Manel Esteller
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.
Nature genetics 2006;38(5):566-9.
2006: Antti Kokko; Sanna S K Ylisaukko-Oja; Maija Kiuru; Maarit Takatalo; Paula Salmikangas; Jarno Tuimala; Diego Arango; Auli Karhu; Lauri A Aaltonen; Jussi Jäntti
Modeling tumor predisposing FH mutations in yeast: effects on fumarase activity, growth phenotype and gene expression profile.
International journal of cancer. Journal international du cancer 2006;118(6):1340-5.
2006: Sakari Vanharanta; Patrick J Pollard; Heli J Lehtonen; Päivi Laiho; Jari Sjöberg; Arto Leminen; Kristiina Aittomäki; Johanna Arola; Mogens Kruhoffer; Torben F Orntoft; Ian P M Tomlinson; Maija Kiuru; Diego Arango; Lauri A Aaltonen
Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.
Human molecular genetics 2006;15(1):97-103.
2005: Hafid Alazzouzi; Veronica Davalos; Antti Kokko; Enric Domingo; Stefan M Woerner; Andrew J Wilson; Lars Konrad; Päivi Laiho; Eloi Espín; Manel Armengol; Kohzoh Imai; Hiroyuki Yamamoto; John M Mariadason; Johannes Gebert; Lauri A Aaltonen; Simo Schwartz; Diego Arango
Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.
Cancer research 2005;65(22):10170-3.
2005: Sakari Vanharanta; Noel C Wortham; Päivi Laiho; Jari Sjöberg; Kristiina Aittomäki; Johanna Arola; Ian P M Tomlinson; Auli Karhu; Diego Arango; Lauri A Aaltonen
7q deletion mapping and expression profiling in uterine fibroids.
Oncogene 2005;24(43):6545-54.
2005: Pia Alhopuro; Hafid Alazzouzi; Heli Sammalkorpi; Verónica Dávalos; Reijo Salovaara; Akseli Hemminki; Heikki Järvinen; Jukka-Pekka Mecklin; Simo Schwartz; Lauri A Aaltonen; Diego Arango
SMAD4 levels and response to 5-fluorouracil in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6311-6.
2005: Diego Arango; Päivi Laiho; Antti Kokko; Pia Alhopuro; Heli Sammalkorpi; Reijo Salovaara; Daniel Nicorici; Sampsa Hautaniemi; Hafid Alazzouzi; Jukka-Pekka Mecklin; Heikki Järvinen; Akseli Hemminki; Jaakko Astola; Simo Schwartz; Lauri A Aaltonen
Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer.
Gastroenterology 2005;129(3):874-84.
2005: Mogens Kruhøffer; Jens Ledet Jensen; Päivi Laiho; Lars Dyrskjøt; Reijo Salovaara; Diego Arango; Karin Birkenkamp-Demtroder; Flemming Brandt Sørensen; Lise Lotte Christensen; L Buhl; Jukka-Pekka Mecklin; Heikki Järvinen; Thomas Thykjaer; Friedrik P Wikman; F Bech-Knudsen; M Juhola; Nina N Nupponen; Søren Laurberg; Claus L Andersen; Lauri A Aaltonen; Torben F Ørntoft
Gene expression signatures for colorectal cancer microsatellite status and HNPCC.
British journal of cancer 2005;92(12):2240-8.
2005: Tuija Hienonen; Heli Sammalkorpi; Susa Enholm; Pia Alhopuro; Thomas D Barber; Rainer Lehtonen; Nina N Nupponen; Heli J Lehtonen; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Riitta Koistinen; Diego Arango; Virpi Launonen; Bert Vogelstein; Auli Karhu; Lauri A Aaltonen
Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.
Cancer research 2005;65(11):4607-13.
2005: John M Mariadason; Courtney Nicholas; Kaitlin E L'Italien; Min Zhuang; Helena J M Smartt; Barbara G Heerdt; Wancai Yang; Georgia A Corner; Andrew J Wilson; Lidija Klampfer; Diego Arango; Leonard H Augenlicht
Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis.
Gastroenterology 2005;128(4):1081-8.
2005: Hafid Alazzouzi; Pia Alhopuro; Reijo Salovaara; Heli Sammalkorpi; Heikki Järvinen; Jukka-Pekka Mecklin; Akseli Hemminki; Simo Schwartz; Lauri A Aaltonen; Diego Arango
SMAD4 as a prognostic marker in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2606-11.
2004: Diego Arango; Andrew J Wilson; Quihu Shi; Georgia A Corner; M J Arañes; Courtney Nicholas; Martin Lesser; John M Mariadason; Leonard H Augenlicht
Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells.
British journal of cancer 2004;91(11):1931-46.
2004: Carla Oliveira; Jantine L Westra; Diego Arango; Miina Ollikainen; Enric Domingo; Ana Ferreira; Sérgia Velho; Renée C Niessen; Kristina Lagerstedt; Pia Alhopuro; Päivi Laiho; Isabel Veiga; Manuel Teixeira; M J L Ligtenberg; Jan H Kleibeuker; Rolf Sijmons; John T M Plukker; Kohzoh Imai; Pedro Lage; Richard Hamelin; Cristina Albuquerque; Simo Schwartz; Annika Lindblom; Paivi Peltomaki; Hiroyuki Yamamoto; Lauri A Aaltonen; Raquel Seruca; Robert M W Hofstra
Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status.
Human molecular genetics 2004;13(19):2303-11.
2004: John M Mariadason; Diego Arango; Leonard H Augenlicht
Customizing chemotherapy for colon cancer: the potential of gene expression profiling.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2004;7(3):209-18.
2004: Dineo Khabele; Melissa Lopez-Jones; Wancai Yang; Diego Arango; Susan J Gross; Leonard H Augenlicht; Gary L Goldberg
Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer.
Gynecologic oncology 2004;93(1):19-26.
2003: John M Mariadason; Diego Arango; Qiuhu Shi; Andrew J Wilson; Georgia A Corner; Courtney Nicholas; Maria J Aranes; Martin Lesser; Edward L Schwartz; Leonard H Augenlicht
Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin.
Cancer research 2003;63(24):8791-812.
2003: Lidija Klampfer; Jie Huang; Georgia A Corner; John M Mariadason; Diego Arango; Takehiko Sasazuki; Senji Shirasawa; Leonard H Augenlicht
Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression.
The Journal of biological chemistry 2003;278(47):46278-87.
2003: Diego Arango; John M Mariadason; Andrew J Wilson; Wancai Yang; Georgia A Corner; Courtney Nicholas; M J Aranes; Leonard H Augenlicht
c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis.
British journal of cancer 2003;89(9):1757-65.
2003: Andrew J Wilson; Diego Arango; John M Mariadason; Barbara G Heerdt; Leonard H Augenlicht
TR3/Nur77 in colon cancer cell apoptosis.
Cancer research 2003;63(17):5401-7.
2003: Leonard H Augenlicht; Anna Velcich; Lidija Klampfer; Jie Huang; Georgia A Corner; Maria Aranes; Christian L Laboisse; Basil Rigas; Martin Lipkin; Kan Yang; Quihu Shi; Martin Lesser; Barbara G Heerdt; Diego Arango; Wancai Yang; Andrew J Wilson; John M Mariadason
Application of gene expression profiling to colon cell maturation, transformation and chemoprevention.
The Journal of nutrition 2003;133(7 Suppl):2410S-2416S.
2003: John M Mariadason; Leonard H Augenlicht; Diego Arango
Microarray analysis in the clinical management of cancer.
Hematology/oncology clinics of North America 2003;17(2):377-87.
2002: Leonard H Augenlicht; John M Mariadason; Andrew J Wilson; Diego Arango; Wancai Yang; Barbara G Heerdt; Anna Velcich
Short chain fatty acids and colon cancer.
The Journal of nutrition 2002;132(12):3804S-3808S.
2002: Andrew J Wilson; Anna Velcich; Diego Arango; Amy R Kurland; Shailesh M Shenoy; Rossanna C Pezo; Jeffrey M. Levsky; Robert H Singer; Leonard H Augenlicht
Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention.
Cancer research 2002;62(21):6006-10.
2002: John M Mariadason; Diego Arango; Georgia A Corner; Maria J Arañes; Kylie A Hotchkiss; Wancai Yang; Leonard H Augenlicht
A gene expression profile that defines colon cell maturation in vitro.
Cancer research 2002;62(16):4791-804.
2001: Leonard H Augenlicht; S Wadler; Diego Arango
Clinical response to fluorouracil and p53.
The New England journal of medicine 2001;345(14):1065-6.
2001: Diego Arango; Georgia A Corner; Scott Wadler; Paul J Catalano; Leonard H Augenlicht
c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo.
Cancer research 2001;61(12):4910-5.