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Benoit Giasson

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Todd E Golde; David R Borchelt; Benoit I Giasson; Jada Lewis
Thinking laterally about neurodegenerative proteinopathies.
Jason P Covy; Elisa A Waxman; Benoit I Giasson
Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants.
Kristel L Emmer; Jason P Covy; Elisa A Waxman; Benoit I Giasson
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.

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All Publications

2013: Todd E Golde; David R Borchelt; Benoit I Giasson; Jada Lewis
Thinking laterally about neurodegenerative proteinopathies.
The Journal of clinical investigation 2013;123(5):1847-55.
2012: Jason P Covy; Elisa A Waxman; Benoit I Giasson
Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants.
Journal of neuroscience research 2012;90(12):2306-16.
2011: Kristel L Emmer; Jason P Covy; Elisa A Waxman; Benoit I Giasson
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.
The Journal of biological chemistry 2011;286(40):35104-18.
2011: Jason P Covy; Benoit I Giasson
α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease.
Neurotoxicology 2011;32(5):622-9.
2011: Elisa A Waxman; Benoit I Giasson
Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(21):7604-18.
2011: Elisa A Waxman; Benoit I Giasson
Characterization of kinases involved in the phosphorylation of aggregated α-synuclein.
Journal of neuroscience research 2011;89(2):231-47.
2010: Ozlem Goker-Alpan; Barbara K Stubblefield; Benoit I Giasson; Ellen Sidransky
Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders.
Acta neuropathologica 2010;120(5):641-9.
2010: Chenere P Ramsey; Benoit I Giasson
L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments.
Journal of neuroscience research 2010;88(14):3111-24.
2010: Jason P Covy; Benoit I Giasson
The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition.
Journal of neurochemistry 2010;115(1):36-46.
2010: Ling-Yang Hao; Benoit I Giasson; Nancy M Bonini
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9747-52.
2010: Yien-Ming Kuo; Zhishan Li; Yun Jiao; Nathalie Gaborit; Amar K Pani; Bonnie M Orrison; Benoit G Bruneau; Benoit I Giasson; Richard J Smeyne; Michael D Gershon; Robert L Nussbaum
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.
Human molecular genetics 2010;19(9):1633-50.
2010: Chenere P Ramsey; Elpida Tsika; Harry Ischiropoulos; Benoit I Giasson
DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.
Human molecular genetics 2010;19(8):1425-37.
2010: Elisa A Waxman; Benoit I Giasson
A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation.
Journal of neurochemistry 2010;113(2):374-88.
2010: Chenere P Ramsey; Benoit I Giasson
Identification and characterization of a novel endogenous murine parkin mutation.
Journal of neurochemistry 2010;113(2):402-17.
2010: Elpida Tsika; Maria Moysidou; Jing Guo; Mimi Cushman; Patrick Gannon; Raphael Sandaltzopoulos; Benoit I Giasson; Dimitri Krainc; Harry Ischiropoulos; Joseph R Mazzulli
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(9):3409-18.
2010: Elisa A Waxman; Kristel L Emmer; Benoit I Giasson
Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation.
Biochemical and biophysical research communications 2010;391(3):1415-20.
2009: Elisa A Waxman; Joseph R Mazzulli; Benoit I Giasson
Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization.
Biochemistry 2009;48(40):9427-36.
2009: Elisa A Waxman; Jason P Covy; Irene Bukh; Xiaojie Li; Ted M Dawson; Benoit I Giasson
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.
Journal of neuropathology and experimental neurology 2009;68(7):785-96.
2009: Elisa A Waxman; Benoit I Giasson
Molecular mechanisms of alpha-synuclein neurodegeneration.
Biochimica et biophysica acta 2009;1792(7):616-24.
2009: Jason P Covy; Benoit I Giasson
Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2.
Biochemical and biophysical research communications 2009;378(3):473-7.
2009: Jason P Covy; Wuxing Yuan; Elisa A Waxman; Howard I Hurtig; Vivianna M Van Deerlin; Benoit I Giasson
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
Movement disorders : official journal of the Movement Disorder Society 2009;24(1):32-9.
2008: Chenere P Ramsey; Benoit I Giasson
The E163K DJ-1 mutant shows specific antioxidant deficiency.
Brain research 2008;1239():1-11.
2008: Elisa A Waxman; John E Duda; Benoit I Giasson
Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions.
Acta neuropathologica 2008;116(1):37-46.
2008: Elisa A Waxman; Benoit I Giasson
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.
Journal of neuropathology and experimental neurology 2008;67(5):402-16.
2008: Andis Klegeris; Steven Pelech; Benoit I Giasson; John Maguire; Hong Zhang; Edith G McGeer; Patrick L McGeer
Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia.
Neurobiology of aging 2008;29(5):739-52.
2008: Wen-Liang Song; John A Lawson; Dermot Reilly; Joshua Rokach; Chih-Tsung Chang; Benoit I Giasson; garret fitzgerald
Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid.
The Journal of biological chemistry 2008;283(1):6-16.
2008: Benoit I Giasson; Vivianna M Van Deerlin
Mutations in LRRK2 as a cause of Parkinson's disease.
Neuro-Signals 2008;16(1):99-105.
2007: Erin H Norris; Kunihiro Uryu; Susan Leight; Benoit I Giasson; John Q Trojanowski; Virginia M-Y Lee
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.
The American journal of pathology 2007;170(2):658-66.
2007: Chenere P Ramsey; Benoit I Giasson
Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment.
Drugs & aging 2007;24(2):95-105.
2006: Andis Klegeris; Benoit I Giasson; Hong Zhang; John Maguire; Steven Pelech; Patrick L McGeer
Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2000-8.
2006: Joseph R Mazzulli; Amanda J Mishizen; Benoit I Giasson; David R Lynch; Steven A Thomas; Akira Nakashima; Toshiharu Nagatsu; Akira Ota; Harry Ischiropoulos
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(39):10068-78.
2006: Ozlem Goker-Alpan; Benoit I Giasson; Michael J Eblan; J Nguyen; Howard I Hurtig; Virginia M-Y Lee; John Q Trojanowski; Ellen Sidransky
Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.
Neurology 2006;67(5):908-10.
2006: Kunihiro Uryu; Christiane Richter-Landsberg; William Welch; Eveline Sun; Olaf Goldbaum; Erin H Norris; Chi-Tuan Pham; Ikuru Yazawa; Kristen Hilburger; Matthew Micsenyi; Benoit I Giasson; Nancy M Bonini; Virginia M-Y Lee; John Q Trojanowski
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.
The American journal of pathology 2006;168(3):947-61.
2006: Benoit I Giasson; Jason P Covy; Nancy M Bonini; Howard I Hurtig; Matthew J Farrer; John Q Trojanowski; Vivianna M Van Deerlin
Biochemical and pathological characterization of Lrrk2.
Annals of neurology 2006;59(2):315-22.
2005: Nancy M Bonini; Benoit I Giasson
Snaring the function of alpha-synuclein.
Cell 2005;123(3):359-61.
2005: Changwei Liu; Benoit I Giasson; Karen A Lewis; Virginia M-Y Lee; George N DeMartino; Philip J Thomas
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.
The Journal of biological chemistry 2005;280(24):22670-8.
2005: Erin H Norris; Benoit I Giasson; Roberto Hodara; Shaohua Xu; John Q Trojanowski; Harry Ischiropoulos; Virginia M-Y Lee
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.
The Journal of biological chemistry 2005;280(22):21212-9.
2005: Marc C Meulener; Charles L Graves; Deepak M Sampathu; Cecilia E Armstrong-Gold; Nancy M Bonini; Benoit I Giasson
DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein.
Journal of neurochemistry 2005;93(6):1524-32.
2005: Amanda J Mishizen-Eberz; Erin H Norris; Benoit I Giasson; Roberto Hodara; Harry Ischiropoulos; Virginia M-Y Lee; John Q Trojanowski; David R Lynch
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Biochemistry 2005;44(21):7818-29.
2005: Erin H Norris; Benoit I Giasson
Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders.
Antioxidants & redox signaling 2005;7(5-6):672-84.
2005: Ikuru Yazawa; Benoit I Giasson; Ryogen Sasaki; Bin Zhang; Sonali Joyce; Kunihiro Uryu; John Q Trojanowski; Virginia M-Y Lee
Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration.
Neuron 2005;45(6):847-59.
2005: Eric A Greenbaum; Charles L Graves; Amanda J Mishizen-Eberz; Michael A Lupoli; David R Lynch; S Walter Englander; Paul H Axelsen; Benoit I Giasson
The E46K mutation in alpha-synuclein increases amyloid fibril formation.
The Journal of biological chemistry 2005;280(9):7800-7.
2004: Benoit I Giasson
Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease?
Science of aging knowledge environment : SAGE KE 2004;2004(48):pe42.
2004: Roberto Hodara; Erin H Norris; Benoit I Giasson; Amanda J Mishizen-Eberz; David R Lynch; Virginia M-Y Lee; Harry Ischiropoulos
Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.
The Journal of biological chemistry 2004;279(46):47746-53.
2004: Paul T Kotzbauer; Benoit I Giasson; Alexxai V Kravitz; Lawrence I Golbe; Margery H Mark; John Q Trojanowski; Virginia M-Y Lee
Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.
Experimental neurology 2004;187(2):279-88.
2004: Christina A Wilson; Diane D Murphy; Benoit I Giasson; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.
The Journal of cell biology 2004;165(3):335-46.
2004: Virginia M-Y Lee; Benoit I Giasson; John Q Trojanowski
More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.
Trends in neurosciences 2004;27(3):129-34.
2004: Erin H Norris; Benoit I Giasson; Virginia M-Y Lee
Alpha-synuclein: normal function and role in neurodegenerative diseases.
Current topics in developmental biology 2004;60():17-54.
2003: Aaron C Pawlyk; Benoit I Giasson; Deepak M Sampathu; Francisco A Perez; Kah Leong Lim; Valina Dawson; Ted M Dawson; Richard D Palmiter; John Q Trojanowski; Virginia M-Y Lee
Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.
The Journal of biological chemistry 2003;278(48):48120-8.
2003: Kunihiro Uryu; Benoit I Giasson; Luca Longhi; D Martinez; I Murray; Valeria Conte; M Nakamura; Kathryn E Saatman; Konrad Talbot; T Horiguchi; Tracy McIntosh; Virginia M-Y Lee; John Q Trojanowski
Age-dependent synuclein pathology following traumatic brain injury in mice.
Experimental neurology 2003;184(1):214-24.
2003: Adam S Crystal; Benoit I Giasson; Alexander Crowe; Mei-Ping Kung; Zhi-Ping Zhuang; John Q Trojanowski; Virginia M-Y Lee
A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114.
Journal of neurochemistry 2003;86(6):1359-68.
2003: Takashi Horiguchi; Kunihiro Uryu; Benoit I Giasson; Harry Ischiropoulos; Richard LightFoot; Christine Bellmann; Christiane Richter-Landsberg; Virginia M-Y Lee; John Q Trojanowski
Nitration of tau protein is linked to neurodegeneration in tauopathies.
The American journal of pathology 2003;163(3):1021-31.
2003: Benoit I Giasson; Meghann E Mabon; John E Duda; Thomas J Montine; David Robertson; Howard I Hurtig; Virginia M-Y Lee; John Q Trojanowski
Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy.
Acta neuropathologica 2003;106(3):243-50.
2003: Amanda J Mishizen-Eberz; Rodney P Guttmann; Benoit I Giasson; George A Day; Roberto Hodara; Harry Ischiropoulos; Virginia M-Y Lee; John Q Trojanowski; David R Lynch
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro.
Journal of neurochemistry 2003;86(4):836-47.
2003: Kar-Ming Fung; Lucy B Rorke; Benoit I Giasson; Virginia M-Y Lee; John Q Trojanowski
Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas.
Acta neuropathologica 2003;106(2):167-75.
2003: Ian V J Murray; Benoit I Giasson; Shawn M Quinn; Vishwanath Koppaka; Paul H Axelsen; Harry Ischiropoulos; John Q Trojanowski; Virginia M-Y Lee
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.
Biochemistry 2003;42(28):8530-40.
2003: Erin H Norris; Benoit I Giasson; Harry Ischiropoulos; Virginia M-Y Lee
Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.
The Journal of biological chemistry 2003;278(29):27230-40.
2003: Benoit I Giasson; Virginia M-Y Lee
Are ubiquitination pathways central to Parkinson's disease?
Cell 2003;114(1):1-8.
2003: Deepak M Sampathu; Benoit I Giasson; Aaron C Pawlyk; John Q Trojanowski; Virginia M-Y Lee
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.
The American journal of pathology 2003;163(1):91-100.
2003: Benoit I Giasson; Mark S Forman; Makoto Higuchi; Lawrence I Golbe; Charles L Graves; Paul T Kotzbauer; John Q Trojanowski; Virginia M-Y Lee
Initiation and synergistic fibrillization of tau and alpha-synuclein.
Science (New York, N.Y.) 2003;300(5619):636-40.
2003: Benoit I Giasson; Virginia M-Y Lee; John Q Trojanowski
Interactions of amyloidogenic proteins.
Neuromolecular medicine 2003;4(1-2):49-58.
2002: Benoit I Giasson; Deepak M Sampathu; Christina A Wilson; Vanessa Vogelsberg-Ragaglia; Walter E Mushynski; Virginia M-Y Lee
The environmental toxin arsenite induces tau hyperphosphorylation.
Biochemistry 2002;41(51):15376-87.
2002: Manuela Neumann; Philipp J Kahle; Benoit I Giasson; Laurence Ozmen; Edilio Borroni; Will Spooren; Veronika Müller; Sabine Odoy; Hideo Fujiwara; Masato Hasegawa; Takeshi Iwatsubo; John Q Trojanowski; Hans A Kretzschmar; Christian Haass
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
The Journal of clinical investigation 2002;110(10):1429-39.
2002: Zhong-Zong Pan; Wendy Bruening; Benoit I Giasson; Virginia M-Y Lee; Andrew K Godwin
Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways.
The Journal of biological chemistry 2002;277(38):35050-60.
2002: John E Duda; Benoit I Giasson; Meghann E Mabon; Virginia M-Y Lee; John Q Trojanowski
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.
Annals of neurology 2002;52(2):205-10.
2002: Hsueh-Ning Liu; Benoit I Giasson; Walter E Mushynski; Guillermina Almazan
AMPA receptor-mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3.
Journal of neurochemistry 2002;82(2):398-409.
2002: John E Duda; Benoit I Giasson; Meghann E Mabon; Douglas C Miller; Lawrence I Golbe; Virginia M-Y Lee; John Q Trojanowski
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
Acta neuropathologica 2002;104(1):7-11.
2002: Benoit I Giasson; Harry Ischiropoulos; Virginia M-Y Lee; John Q Trojanowski
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases.
Free radical biology & medicine 2002;32(12):1264-75.
2002: Benoit I Giasson; John E Duda; Shawn M Quinn; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.
Neuron 2002;34(4):521-33.
2001: Benoit I Giasson; John E Duda; Mark S Forman; Virginia M-Y Lee; John Q Trojanowski
Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons.
Experimental neurology 2001;172(2):354-62.
2001: Evgenia Paxinou; Q Chen; M Weisse; Benoit I Giasson; Erin H Norris; S M Rueter; John Q Trojanowski; Virginia M-Y Lee; Harry Ischiropoulos
Induction of alpha-synuclein aggregation by intracellular nitrative insult.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(20):8053-61.
2001: Benoit I Giasson; Virginia M-Y Lee
Parkin and the molecular pathways of Parkinson's disease.
Neuron 2001;31(6):885-8.
2001: M Luise Schmidt; Teresa Schuck; S Sheridan; Mei-Ping Kung; H Kung; Zhi-Ping Zhuang; Catherine Bergeron; J S Lamarche; Daniel M Skovronsky; Benoit I Giasson; Virginia M-Y Lee; John Q Trojanowski
The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains.
The American journal of pathology 2001;159(3):937-43.
2001: Benoit I Giasson; Ian V J Murray; John Q Trojanowski; Virginia M-Y Lee
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.
The Journal of biological chemistry 2001;276(4):2380-6.
2001: Serge Przedborski; Q Chen; Miquel Vila; Benoit I Giasson; R Djaldatti; S Vukosavic; José M Souza; Vernice Jackson-Lewis; Virginia M-Y Lee; Harry Ischiropoulos
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.
Journal of neurochemistry 2001;76(2):637-40.
2000: Benoit I Giasson; Virginia M-Y Lee
A new link between pesticides and Parkinson's disease.
Nature neuroscience 2000;3(12):1227-8.
2000: Benoit I Giasson; John E Duda; Ian V J Murray; Q Chen; José M Souza; Howard I Hurtig; Harry Ischiropoulos; John Q Trojanowski; Virginia M-Y Lee
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.
Science (New York, N.Y.) 2000;290(5493):985-9.
2000: John E Duda; Benoit I Giasson; Q Chen; Tamar L Gur; Howard I Hurtig; Matthew B Stern; SM Gollomp; Harry Ischiropoulos; Virginia M-Y Lee; John Q Trojanowski
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
The American journal of pathology 2000;157(5):1439-45.
2000: John E Duda; Benoit I Giasson; Tamar L Gur; Thomas J Montine; David Robertson; I Biaggioni; Howard I Hurtig; Matthew B Stern; SM Gollomp; Murray Grossman; Virginia M-Y Lee; John Q Trojanowski
Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy.
Journal of neuropathology and experimental neurology 2000;59(9):830-41.
2000: James E Galvin; Benoit I Giasson; Howard I Hurtig; Virginia M-Y Lee; John Q Trojanowski
Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.
The American journal of pathology 2000;157(2):361-8.
2000: José M Souza; Benoit I Giasson; Q Chen; Virginia M-Y Lee; Harry Ischiropoulos
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies.
The Journal of biological chemistry 2000;275(24):18344-9.
2000: José M Souza; Benoit I Giasson; Virginia M-Y Lee; Harry Ischiropoulos
Chaperone-like activity of synucleins.
FEBS letters 2000;474(1):116-9.
2000: Wendy Bruening; Benoit I Giasson; Andres J P Klein-Szanto; Virginia M-Y Lee; John Q Trojanowski; Andrew K Godwin
Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary.
Cancer 2000;88(9):2154-63.
2000: Benoit I Giasson; Ross Jakes; Michel Goedert; John E Duda; Susan Leight; John Q Trojanowski; Virginia M-Y Lee
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.
Journal of neuroscience research 2000;59(4):528-33.
1999: Benoit I Giasson; Kunihiro Uryu; John Q Trojanowski; Virginia M-Y Lee
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro.
The Journal of biological chemistry 1999;274(12):7619-22.
1999: Benoit I Giasson; Wendy Bruening; Heather D Durham; Walter E Mushynski
Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells.
Journal of neurochemistry 1999;72(3):1081-7.
1999: Wendy Bruening; J Roy; Benoit I Giasson; Denise A Figlewicz; Walter E Mushynski; Heather D Durham
Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis.
Journal of neurochemistry 1999;72(2):693-9.
1998: Carol F Lippa; H Fujiwara; D M A Mann; Benoit I Giasson; M Baba; ML Schmidt; Linda E Nee; B O'Connell; Daniel A Pollen; Peter St George-Hyslop; Bernardino Ghetti; David Nochlin; Thomas D Bird; Nigel J Cairns; Virginia M-Y Lee; Takeshi Iwatsubo; John Q Trojanowski
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
The American journal of pathology 1998;153(5):1365-70.
1998: Pang-hsien Tu; James E Galvin; M Baba; Benoit I Giasson; Taisuke Tomita; Susan Leight; S Nakajo; Takeshi Iwatsubo; John Q Trojanowski; Virginia M-Y Lee
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.
Annals of neurology 1998;44(3):415-22.
1998: Benoit I Giasson; Walter E Mushynski
Intermediate filament disassembly in cultured dorsal root ganglion neurons is associated with amino-terminal head domain phosphorylation of specific subunits.
Journal of neurochemistry 1998;70(5):1869-75.
1998: Wendy Bruening; Benoit I Giasson; Walter E Mushynski; Heather D Durham
Activation of stress-activated MAP protein kinases up-regulates expression of transgenes driven by the cytomegalovirus immediate/early promoter.
Nucleic acids research 1998;26(2):486-9.
1997: Benoit I Giasson; Walter E Mushynski
Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(24):9466-72.
1997: Benoit I Giasson; Walter E Mushynski
Developmentally regulated stabilization of neuronal intermediate filaments in rat cerebral cortex.
Neuroscience letters 1997;229(2):77-80.
1997: Benoit I Giasson; Walter E Mushynski
Okadaic acid reversibly inhibits neurite outgrowth in embryonic dorsal root ganglion neurons.
Journal of neurobiology 1997;32(2):193-201.
1996: Benoit I Giasson; Walter E Mushynski
Aberrant stress-induced phosphorylation of perikaryal neurofilaments.
The Journal of biological chemistry 1996;271(48):30404-9.
1996: Benoit I Giasson; J A Cromlish; E S Athlan; Walter E Mushynski
Activation of cyclic AMP-dependent protein kinase in okadaic acid-treated neurons potentiates neurofilament fragmentation and stimulates phosphorylation of Ser2 in the low-molecular-mass neurofilament subunit.
Journal of neurochemistry 1996;66(3):1207-13.
1995: D Jayaraman; Benoit I Giasson; Walter E Mushynski
Increased phosphorylation of neurofilament subunits in PC12 cells and rat dorsal root ganglion neurons treated with N-Acetyl-Leu-Leu-norleucinal.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1995;13(7):753-8.