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Geoffrey Gibbons

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Abdel M Hebbachi; Brian L Knight; David Wiggins; Dilip D Patel; Geoffrey F Gibbons
Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha.
Celia G Walker; Mark J Holness; Geoffrey F Gibbons; Mary C Sugden
Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency.
Celia G Walker; Mary C Sugden; Geoffrey F Gibbons; Mark J Holness
Peroxisome proliferator-activated receptor alpha deficiency modifies glucose handling by isolated mouse adipocytes.

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2008: Abdel M Hebbachi; Brian L Knight; David Wiggins; Dilip D Patel; Geoffrey F Gibbons
Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha.
The Journal of biological chemistry 2008;283(8):4866-76.
2007: Celia G Walker; Mark J Holness; Geoffrey F Gibbons; Mary C Sugden
Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency.
International journal of obesity (2005) 2007;31(7):1165-71.
2007: Celia G Walker; Mary C Sugden; Geoffrey F Gibbons; Mark J Holness
Peroxisome proliferator-activated receptor alpha deficiency modifies glucose handling by isolated mouse adipocytes.
The Journal of endocrinology 2007;193(1):39-43.
2005: Andrew James Murray; Marcello Panagia; David Hauton; Geoffrey F Gibbons; Kieran Clarke
Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels.
Diabetes 2005;54(12):3496-502.
2005: William E W Roediger; Geoffrey F Gibbons
Inflammatory demyelination could be attributed to nitric oxide inhibition of cytosolic CoA with failed lipogenesis.
Journal of neurology 2005;252(11):1418-9.
2005: Brian L Knight; Abdul M Hebbachi; David Hauton; Anna-Marie Brown; David Wiggins; Dilipkumar D Patel; Geoffrey F Gibbons
A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.
The Biochemical journal 2005;389(Pt 2):413-21.
2005: Christopher J Lelliott; Miguel López; R Keira Curtis; Nadeene Parker; Matthias Laudes; Giles Yeo; Mercedes Jimenez-Liñan; Johannes Grosse; Asish K Saha; David Wiggins; David Hauton; Martin D Brand; Stephen O'Rahilly; Julian L Griffin; Geoffrey F Gibbons; Antonio Vidal-Puig
Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1108-19.
2005: K K Islam; Brian L Knight; K N Frayn; Dilipkumar D Patel; Geoffrey F Gibbons
Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue.
Biochimica et biophysica acta 2005;1734(3):259-68.
2005: Marcello Panagia; Geoffrey F Gibbons; George K Radda; Kieran Clarke
PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia.
American journal of physiology. Heart and circulatory physiology 2005;288(6):H2677-83.
2005: Robert K Semple; Aline Meirhaeghe; Antonio Vidal-Puig; John W R Schwabe; David Wiggins; Geoffrey F Gibbons; Mark Gurnell; V Krishna K Chatterjee; Stephen O'Rahilly
A dominant negative human peroxisome proliferator-activated receptor (PPAR){alpha} is a constitutive transcriptional corepressor and inhibits signaling through all PPAR isoforms.
Endocrinology 2005;146(4):1871-82.
2004: Julian L Griffin; Stephanie A Bonney; Chris Mann; Abdul M Hebbachi; Geoffrey F Gibbons; Jeremy K Nicholson; Carol C Shoulders; James Scott
An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.
Physiological genomics 2004;17(2):140-9.
2004: Geoffrey F Gibbons; David Wiggins; AM Brown; Abdul M Hebbachi
Synthesis and function of hepatic very-low-density lipoprotein.
Biochemical Society transactions 2004;32(Pt 1):59-64.
2004: William E Roediger; Reginald Hems; David Wiggins; Geoffrey F Gibbons
Inhibition of hepatocyte lipogenesis by nitric oxide donor: could nitric oxide regulate lipid synthesis?
IUBMB life 2004;56(1):35-40.
2003: Geoffrey F Gibbons
Regulation of fatty acid and cholesterol synthesis: co-operation or competition?
Progress in lipid research 2003;42(6):479-97.
2003: Brian L Knight; Dilipkumar D Patel; Sandy M Humphreys; David Wiggins; Geoffrey F Gibbons
Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice.
Journal of lipid research 2003;44(11):2049-58.
2002: Geoffrey F Gibbons
The role of cytochrome P450 in the regulation of cholesterol biosynthesis.
Lipids 2002;37(12):1163-70.
2002: Geoffrey F Gibbons
From gallstones to genes: two hundred years of sterol research. A tribute to George J. Schroepfer Jr.
Lipids 2002;37(12):1153-62.
2002: Mark J Holness; Karen Bulmer; Geoffrey F Gibbons; Mary C Sugden
Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha).
The Biochemical journal 2002;366(Pt 3):839-46.
2002: Mark J Holness; Nicholas Smith; Karen Bulmer; Teresa A Hopkins; Geoffrey F Gibbons; Mary C Sugden
Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism.
The Biochemical journal 2002;364(Pt 3):687-94.
2002: Mary C Sugden; Karen Bulmer; Geoffrey F Gibbons; Brian L Knight; Mark J Holness
Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin.
The Biochemical journal 2002;364(Pt 2):361-8.
2002: Geoffrey F Gibbons; AM Brown; David Wiggins; Richard J Pease
The roles of insulin and fatty acids in the regulation of hepatic very-low-density lipoprotein assembly.
Journal of the Royal Society of Medicine 2002;95 Suppl 42():23-32.
2002: Geoffrey F Gibbons; Dilip Patel; David Wiggins; Brian L Knight
The functional efficiency of lipogenic and cholesterogenic gene expression in normal mice and in mice lacking the peroxisomal proliferator-activated receptor-alpha (PPAR-alpha).
Advances in enzyme regulation 2002;42():227-47.
2001: Mary C Sugden; Karen Bulmer; Geoffrey F Gibbons; Mark J Holness
Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding.
Archives of biochemistry and biophysics 2001;395(2):246-52.
2001: J I Trickett; Dilipkumar D Patel; Brian L Knight; E David Saggerson; Geoffrey F Gibbons; Richard J Pease
Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.
The Journal of biological chemistry 2001;276(43):39522-32.
2001: AM Brown; Geoffrey F Gibbons
Insulin inhibits the maturation phase of VLDL assembly via a phosphoinositide 3-kinase-mediated event.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(10):1656-61.
2001: Abdul M Hebbachi; Geoffrey F Gibbons
Microsomal membrane-associated apoB is the direct precursor of secreted VLDL in primary cultures of rat hepatocytes.
Journal of lipid research 2001;42(10):1609-17.
2001: Dilipkumar D Patel; Brian L Knight; David Wiggins; Sandy M Humphreys; Geoffrey F Gibbons
Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice.
Journal of lipid research 2001;42(3):328-37.
2000: Dilipkumar D Patel; Brian L Knight; Anne K Soutar; Geoffrey F Gibbons; DP Wade
The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene.
The Biochemical journal 2000;351 Pt 3():747-53.
2000: P W Baker; Geoffrey F Gibbons
Effect of dietary fish oil on the sensitivity of hepatic lipid metabolism to regulation by insulin.
Journal of lipid research 2000;41(5):719-26.
2000: P A Field; Geoffrey F Gibbons
Decreased hepatic expression of the low-density lipoprotein (LDL) receptor and LDL receptor-related protein in aging rats is associated with delayed clearance of chylomicrons from the circulation.
Metabolism: clinical and experimental 2000;49(4):492-8.
2000: Geoffrey F Gibbons; K Islam; Richard J Pease
Mobilisation of triacylglycerol stores.
Biochimica et biophysica acta 2000;1483(1):37-57.
1999: Jens Bülow; Lene Simonsen; David Wiggins; Sandy M Humphreys; K N Frayn; D Powell; Geoffrey F Gibbons
Co-ordination of hepatic and adipose tissue lipid metabolism after oral glucose.
Journal of lipid research 1999;40(11):2034-43.
1999: Abdul M Hebbachi; Geoffrey F Gibbons
Inactivation of microsomal triglyceride transfer protein impairs the normal redistribution but not the turnover of newly synthesized glycerolipid in the cytosol, endoplasmic reticulum and Golgi of primary rat hepatocytes.
Biochimica et biophysica acta 1999;1441(1):36-50.
1999: Abdul M Hebbachi; AM Brown; Geoffrey F Gibbons
Suppression of cytosolic triacylglycerol recruitment for very low density lipoprotein assembly by inactivation of microsomal triglyceride transfer protein results in a delayed removal of apoB-48 and apoB-100 from microsomal and Golgi membranes of primary rat hepatocytes.
Journal of lipid research 1999;40(10):1758-68.
1999: A Brown; David Wiggins; Geoffrey F Gibbons
Manipulation of cholesterol and cholesteryl ester synthesis has multiple effects on the metabolism of apolipoprotein B and the secretion of very-low-density lipoprotein by primary hepatocyte cultures.
Biochimica et biophysica acta 1999;1440(2-3):253-65.
1999: Richard J Pease; David Wiggins; E David Saggerson; J Tree; Geoffrey F Gibbons
Metabolic characteristics of a human hepatoma cell line stably transfected with hormone-sensitive lipase.
The Biochemical journal 1999;341 ( Pt 2)():453-60.
1999: AM Brown; David Wiggins; Geoffrey F Gibbons
Glucose phosphorylation is essential for the turnover of neutral lipid and the second stage assembly of triacylglycerol-rich ApoB-containing lipoproteins in primary hepatocyte cultures.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(2):321-9.
1999: AM Brown; J Castle; Abdul M Hebbachi; Geoffrey F Gibbons
Administration of n-3 fatty acids in the diets of rats or directly to hepatocyte cultures results in different effects on hepatocellular ApoB metabolism and secretion.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(1):106-14.
1998: O G Björnsson; C S Bourgeois; Geoffrey F Gibbons
Varying very low-density lipoprotein secretion of rat hepatocytes by altering cellular levels of calcium and the activity of protein kinase C.
European journal of clinical investigation 1998;28(9):720-9.
1998: Andrew Salter; David Wiggins; V A Sessions; Geoffrey F Gibbons
The intracellular triacylglycerol/fatty acid cycle: a comparison of its activity in hepatocytes which secrete exclusively apolipoprotein (apo) B100 very-low-density lipoprotein (VLDL) and in those which secrete predominantly apoB48 VLDL.
The Biochemical journal 1998;332 ( Pt 3)():667-72.
1998: Abdul M Hebbachi; M C Seelaender; Geoffrey F Gibbons
The effect of prostaglandin E2 on the intracellular lipolysis of triacylglycerol in cultured rat hepatocytes.
Biochemical Society transactions 1998;26(2):S159.
1997: P A Field; Geoffrey F Gibbons
Regulation of hepatic chylomicron remnant uptake: effects of obesity and insulin resistance.
Biochemical Society transactions 1997;25(4):S678.
1997: Abdul M Hebbachi; Geoffrey F Gibbons
The effect of dietary n-3 fatty acids on the assembly and secretion of very low density lipoprotein by isolated rat hepatocytes.
Biochemical Society transactions 1997;25(4):S683.
1997: Abdul M Hebbachi; M C Seelaender; B W Baker; Geoffrey F Gibbons
Decreased secretion of very-low-density lipoprotein triacylglycerol and apolipoprotein B is associated with decreased intracellular triacylglycerol lipolysis in hepatocytes derived from rats fed orotic acid or n-3 fatty acids.
The Biochemical journal 1997;325 ( Pt 3)():711-9.
1997: A M Brown; P W Baker; Geoffrey F Gibbons
Changes in fatty acid metabolism in rat hepatocytes in response to dietary n-3 fatty acids are associated with changes in the intracellular metabolism and secretion of apolipoprotein B-48.
Journal of lipid research 1997;38(3):469-81.
1996: David Wiggins; Geoffrey F Gibbons
Origin of hepatic very-low-density lipoprotein triacylglycerol: the contribution of cellular phospholipid.
The Biochemical journal 1996;320 ( Pt 2)():673-9.
1996: P J Coussons; C S Bourgeois; David Wiggins; Geoffrey F Gibbons
Selective recruitment of ApoB-48 for the assembly of VLDL in rat triacylglycerol-enriched hepatocytes.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(7):889-97.
1996: C S Bourgeois; Geoffrey F Gibbons
Decreased sensitivity of very-low-density lipoprotein secretion to the inhibitory effect of insulin in cultured hepatocytes from lactating rats.
The Biochemical journal 1996;316 ( Pt 3)():737-41.
1996: Abdul M Hebbachi; Geoffrey F Gibbons
Retention of orotic acid effect on very low density lipoproteins secretion in cultured hepatocytes.
Biochemical Society transactions 1996;24(2):177S.
1996: C S Bourgeois; David Wiggins; Geoffrey F Gibbons
Chronic exogenous hyperinsulinaemia does not modify the acute inhibitory effect of insulin on the secretion of very-low-density lipoprotein triacylglycerol and apolipoprotein B in primary cultures of rat hepatocytes.
The Biochemical journal 1996;314 ( Pt 1)():103-8.
1995: D J Brett; R J Pease; James Scott; Geoffrey F Gibbons
Microsomal triglyceride transfer protein activity remains unchanged in rat livers under conditions of altered very-low-density lipoprotein secretion.
The Biochemical journal 1995;310 ( Pt 1)():11-4.
1995: Geoffrey F Gibbons; D Wiggins
The enzymology of hepatic very-low-density lipoprotein assembly.
Biochemical Society transactions 1995;23(3):495-500.
1995: C S Bourgeois; David Wiggins; R Hems; Geoffrey F Gibbons
VLDL output by hepatocytes from obese Zucker rats is resistant to the inhibitory effect of insulin.
The American journal of physiology 1995;269(2 Pt 1):E208-15.
1995: David Wiggins; R Hems; Geoffrey F Gibbons
Decreased sensitivity to the inhibitory effect of insulin on the secretion of very-low-density lipoprotein in cultured hepatocytes from fructose-fed rats.
Metabolism: clinical and experimental 1995;44(7):841-7.
1995: R M Fisher; S W Coppack; Sandy M Humphreys; Geoffrey F Gibbons; Keith N Frayn
Human triacylglycerol-rich lipoprotein subfractions as substrates for lipoprotein lipase.
Clinica chimica acta; international journal of clinical chemistry 1995;236(1):7-17.
1995: J L Potts; S W Coppack; R M Fisher; Sandy M Humphreys; Geoffrey F Gibbons; Keith N Frayn
Impaired postprandial clearance of triacylglycerol-rich lipoproteins in adipose tissue in obese subjects.
The American journal of physiology 1995;268(4 Pt 1):E588-94.
1995: Geoffrey F Gibbons; D Wiggins
Intracellular triacylglycerol lipase: its role in the assembly of hepatic very-low-density lipoprotein (VLDL).
Advances in enzyme regulation 1995;35():179-98.
1994: J L Potts; R M Fisher; Sandy M Humphreys; Geoffrey F Gibbons; Keith N Frayn
Separation of lipoprotein fractions by ultracentrifugation: investigation of analytical recovery with sequential flotation and density gradient procedures.
Clinica chimica acta; international journal of clinical chemistry 1994;230(2):215-20.
1994: Geoffrey F Gibbons; R Khurana; A Odwell; M C Seelaender
Lipid balance in HepG2 cells: active synthesis and impaired mobilization.
Journal of lipid research 1994;35(10):1801-8.
1994: J L Potts; Sandy M Humphreys; S W Coppack; R M Fisher; Geoffrey F Gibbons; Keith N Frayn
Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal.
The British journal of nutrition 1994;72(1):101-9.
1994: R E Carr; C S Bourgeois; Keith N Frayn; Geoffrey F Gibbons
A convenient method for assaying insulin responsiveness of rat adipose tissue in primary culture.
Biochemical Society transactions 1994;22(2):100S.
1994: O G Björnsson; Janet D Sparks; Charles E Sparks; Geoffrey F Gibbons
Regulation of VLDL secretion in primary culture of rat hepatocytes: involvement of cAMP and cAMP-dependent protein kinases.
European journal of clinical investigation 1994;24(2):137-48.
1993: J M Duerden; Geoffrey F Gibbons
Restoration in vitro of normal rates of very-low-density lipoprotein triacylglycerol and apoprotein B secretion in hepatocyte cultures from diabetic rats.
The Biochemical journal 1993;294 ( Pt 1)():167-71.
1993: R M Fisher; S W Coppack; Geoffrey F Gibbons; Keith N Frayn
Post-prandial VLDL subfraction metabolism in normal and obese subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1993;17(5):263-9.
1992: Geoffrey F Gibbons; S M Bartlett; Charles E Sparks; Janet D Sparks
Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes.
The Biochemical journal 1992;287 ( Pt 3)():749-53.
1992: O G Björnsson; Janet D Sparks; Charles E Sparks; Geoffrey F Gibbons
Prostaglandins suppress VLDL secretion in primary rat hepatocyte cultures: relationships to hepatic calcium metabolism.
Journal of lipid research 1992;33(7):1017-27.
1992: D Wiggins; Geoffrey F Gibbons
The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas.
The Biochemical journal 1992;284 ( Pt 2)():457-62.
1992: S W Coppack; R D Evans; R M Fisher; Keith N Frayn; Geoffrey F Gibbons; Sandy M Humphreys; M L Kirk; J L Potts; T D Hockaday
Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal.
Metabolism: clinical and experimental 1992;41(3):264-72.
1992: O G Björnsson; J M Duerden; S M Bartlett; Janet D Sparks; Charles E Sparks; Geoffrey F Gibbons
The role of pancreatic hormones in the regulation of lipid storage, oxidation and secretion in primary cultures of rat hepatocytes. Short- and long-term effects.
The Biochemical journal 1992;281 ( Pt 2)():381-6.
1991: J L Potts; R M Fisher; Sandy M Humphreys; S W Coppack; Geoffrey F Gibbons; Keith N Frayn
Peripheral triacylglycerol extraction in the fasting and post-prandial states.
Clinical science (London, England : 1979) 1991;81(5):621-6.
1991: J L Potts; R M Fisher; Sandy M Humphreys; S W Coppack; Geoffrey F Gibbons; Keith N Frayn
Chylomicrons are the preferred substrate for lipoprotein lipase in vivo.
Biochemical Society transactions 1991;19(3):314S.
1991: Geoffrey F Gibbons; F J Burnham
Effect of nutritional state on the utilization of fatty acids for hepatitic triacylglycerol synthesis and secretion as very-low-density lipoprotein.
The Biochemical journal 1991;275 ( Pt 1)():87-92.
1990: J M Duerden; Geoffrey F Gibbons
Storage, mobilization and secretion of cytosolic triacylglycerol in hepatocyte cultures. The role of insulin.
The Biochemical journal 1990;272(3):583-7.
1990: J L Potts; R M Fisher; S W Coppack; Geoffrey F Gibbons; Keith N Frayn
Lipoprotein interconversions during passage through subcutaneous adipose tissue in humans in vivo.
Biochemical Society transactions 1990;18(6):1196-7.
1990: J M Duerden; B Marsh; F J Burnham; Geoffrey F Gibbons
Regulation of hepatic synthesis and secretion of cholesterol and glycerolipids in animals maintained in different nutritional states.
The Biochemical journal 1990;271(3):761-6.
1990: S W Coppack; R M Fisher; Geoffrey F Gibbons; Sandy M Humphreys; M J McDonough; J L Potts; Keith N Frayn
Postprandial substrate deposition in human forearm and adipose tissues in vivo.
Clinical science (London, England : 1979) 1990;79(4):339-48.
1990: Geoffrey F Gibbons
Assembly and secretion of hepatic very-low-density lipoprotein.
The Biochemical journal 1990;268(1):1-13.
1989: J Iglesias; Geoffrey F Gibbons
Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol.
The Biochemical journal 1989;264(2):495-502.
1989: J M Duerden; S M Bartlett; Geoffrey F Gibbons
Long-term maintenance of high rates of very-low-density-lipoprotein secretion in hepatocyte cultures. A model for studying the direct effects of insulin and insulin deficiency in vitro.
The Biochemical journal 1989;263(3):937-43.
1989: J M Duerden; S M Bartlett; Geoffrey F Gibbons
Regulation of very-low-density-lipoprotein lipid secretion in hepatocyte cultures derived from diabetic animals.
The Biochemical journal 1989;262(1):313-9.
1989: J Iglesias; Geoffrey F Gibbons
Oxidative metabolism of cholesterol precursors: sensitivity to ketoconazole, an inhibitor of cytochrome P-450.
Steroids 1989;53(3-5):311-28.
1989: Geoffrey F Gibbons
Insulin, diabetes and hepatic very-low-density lipoprotein metabolism.
Biochemical Society transactions 1989;17(1):49-51.
1989: P R de Vasconcelos; M G Kettlewell; Geoffrey F Gibbons; D H Williamson
Increased rates of hepatic cholesterogenesis and fatty acid synthesis in septic rats in vivo: evidence for the possible involvement of insulin.
Clinical science (London, England : 1979) 1989;76(2):205-11.
1988: J M Duerden; Geoffrey F Gibbons
Secretion and storage of newly synthesized hepatic triacylglycerol fatty acids in vivo in different nutritional states and in diabetes.
The Biochemical journal 1988;255(3):929-35.
1988: C Marco de la Calle; Geoffrey F Gibbons
Hepatic and intestinal formation of polar sterols in vivo in animals fed on a cholesterol-supplemented diet.
The Biochemical journal 1988;252(2):395-9.
1988: C Marco de la Calle; W Hwang; C R Pullinger; Geoffrey F Gibbons
A relationship between the activities of hepatic lanosterol 14 alpha-demethylase and 3-hydroxy-3-methylglutaryl-CoA reductase.
The Biochemical journal 1988;250(1):33-9.
1988: S M Bartlett; Geoffrey F Gibbons
Short- and longer-term regulation of very-low-density lipoprotein secretion by insulin, dexamethasone and lipogenic substrates in cultured hepatocytes. A biphasic effect of insulin.
The Biochemical journal 1988;249(1):37-43.
1987: Geoffrey F Gibbons; C R Pullinger
Regulation of hepatic very-low-density lipoprotein secretion in rats fed on a diet high in unsaturated fat.
The Biochemical journal 1987;243(2):487-92.
1986: Geoffrey F Gibbons; C R Pullinger
Diurnal variations in the effects of an unsaturated-fat-containing diet on fatty acid and cholesterol synthesis in rat hepatocytes.
The Biochemical journal 1986;239(3):617-23.
1986: Geoffrey F Gibbons; C P Attwell Thomas; C R Pullinger
The metabolic route by which oleate is converted into cholesterol in rat hepatocytes.
The Biochemical journal 1986;235(1):19-24.
1985: O G Björnsson; C R Pullinger; Geoffrey F Gibbons
Effect of drugs, peptide hormones and lipogenic precursors on the relative incorporation of [3H]H2O and carbon into hepatic cholesterol.
FEBS letters 1985;187(2):302-6.
1985: O G Björnsson; C R Pullinger; Geoffrey F Gibbons
Diurnal changes in the rate of cholesterogenesis in hepatocytes from fed and starved rats: effects of precursors and pancreatic hormones in vitro.
Archives of biochemistry and biophysics 1985;238(1):135-45.
1985: C R Pullinger; Geoffrey F Gibbons
Effects of hormones and pyruvate on the rates of secretion of very-low-density lipoprotein triacylglycerol and cholesterol by rat hepatocytes.
Biochimica et biophysica acta 1985;833(1):44-51.
1984: Geoffrey F Gibbons; O G Björnsson; C R Pullinger
Evidence that changes in hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity are required partly to maintain a constant rate of sterol synthesis.
The Journal of biological chemistry 1984;259(23):14399-405.
1984: Geoffrey F Gibbons; C R Pullinger; O G Björnsson
Changes in the sensitivity of lipogenesis in rat hepatocytes to hormones and precursors over the diurnal cycle and during longer-term starvation of donor animals.
Journal of lipid research 1984;25(12):1358-67.
1983: C R Pullinger; Geoffrey F Gibbons
The relationship between the rate of hepatic sterol synthesis and the incorporation of [3H]water.
Journal of lipid research 1983;24(10):1321-8.
1983: Geoffrey F Gibbons; C R Pullinger; M R Munday; D H Williamson
Regulation of cholesterol synthesis in the liver and mammary gland of the lactating rat.
The Biochemical journal 1983;212(3):843-8.
1983: C R Pullinger; Geoffrey F Gibbons
The role of substrate supply in the regulation of cholesterol biosynthesis in rat hepatocytes.
The Biochemical journal 1983;210(3):625-32.
1982: C R Pullinger; Geoffrey F Gibbons
Effects of oleate and compactin on the metabolism and secretion of cholesterol and cholesteryl ester by rat hepatocytes.
Biochimica et biophysica acta 1982;713(2):323-32.
1981: C R Pullinger; Geoffrey F Gibbons
A biphasic effect of exogenous oleate on the rate of cholesterol biosynthesis by rat hepatocytes.
Biochemical and biophysical research communications 1981;99(1):37-43.
1980: Geoffrey F Gibbons; C R Pullinger; T A Baillie; R A Clare
Metabolism of hydroxy sterols by rat liver.
Biochimica et biophysica acta 1980;619(1):98-106.
1980: Geoffrey F Gibbons; C R Pullinger; H W Chen; W K Cavenee; A A Kandutsch
Regulation of cholesterol biosynthesis in cultured cells by probable natural precursor sterols.
The Journal of biological chemistry 1980;255(2):395-400.