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Peter Gierschik

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Carolin Koenig; Pamela Fischer-Posovszky; Peter Gierschik; Markus T Rojewski; Hubert Schrezenmeier; Daniel Tews; Martin Wabitsch; Barbara Moepps
Absence of CC chemokine receptors 2a and 2b from human adipose lineage cells.
Jörg Fahrer; Katja Fiedler; Peter Gierschik; Torben Langer; Brigitte Schweitzer; Holger Barth
C2-streptavidin mediates the delivery of biotin-conjugated tumor suppressor protein p53 into tumor cells.
Peter Gierschik; Anja Buehler; Claudia Walliser
Activated PLCγ breaking loose.

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2013: Carolin Koenig; Pamela Fischer-Posovszky; Peter Gierschik; Markus T Rojewski; Hubert Schrezenmeier; Daniel Tews; Martin Wabitsch; Barbara Moepps
Absence of CC chemokine receptors 2a and 2b from human adipose lineage cells.
Molecular and cellular endocrinology 2013;369(1-2):72-85.
2013: Jörg Fahrer; Katja Fiedler; Peter Gierschik; Torben Langer; Brigitte Schweitzer; Holger Barth
C2-streptavidin mediates the delivery of biotin-conjugated tumor suppressor protein p53 into tumor cells.
Bioconjugate chemistry 2013;24(4):595-603.
2012: Peter Gierschik; Anja Buehler; Claudia Walliser
Activated PLCγ breaking loose.
Structure (London, England : 1993) 2012;20(12):1989-90.
2012: Michael Schmohl; Peter Gierschik; Thomas O Joos; Stefanie Rimmele; Nicole Schneiderhan-Marra
Functional analysis of Rho GTPase activation and inhibition in a bead-based miniaturized format.
Methods in molecular biology (Clifton, N.J.) 2012;827():271-82.
2011: Simone Kredel; Michael Wolff; Michael Bieler; Peter Gierschik; Silke Hobbie; Ralf Heilker
High-content analysis of CCR2 antagonists on human primary monocytes.
Journal of biomolecular screening 2011;16(7):683-93.
2011: Katy L Everett; Anja Buehler; Tom D Bunney; Anca Margineanu; Rhona W Baxendale; Petra Vatter; Michael Retlich; Claudia Walliser; Hugh B Manning; Mark A A Neil; Christopher Dunsby; Paul M W French; Peter Gierschik; Matilda Katan
Membrane environment exerts an important influence on rac-mediated activation of phospholipase Cγ2.
Molecular and cellular biology 2011;31(6):1240-51.
2010: Stefanie Rimmele; Peter Gierschik; Thomas O Joos; Nicole Schneiderhan-Marra
Bead-based protein-protein interaction assays for the analysis of Rho GTPase signaling.
Journal of molecular recognition : JMR 2010;23(6):543-50.
2010: Pamela Fischer-Posovszky; Julia von Schnurbein; Barbara Moepps; G Lahr; Gudrun Strauss; Thomas F E Barth; Jan Kassubek; Hannes Mühleder; Peter Möller; Klaus-Michael Debatin; Peter Gierschik; Martin Wabitsch
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness.
The Journal of clinical endocrinology and metabolism 2010;95(6):2836-40.
2010: Orit Gutman; Claudia Walliser; Thomas Piechulek; Peter Gierschik; Yoav I Henis
Differential regulation of phospholipase C-beta2 activity and membrane interaction by Galphaq, Gbeta1gamma2, and Rac2.
The Journal of biological chemistry 2010;285(6):3905-15.
2009: Simone Kredel; Michael Wolff; Joerg Wiedenmann; Barbara Moepps; G Ulrich Nienhaus; Peter Gierschik; Barbara Kistler; Ralf Heilker
CXCR2 inverse agonism detected by arrestin redistribution.
Journal of biomolecular screening 2009;14(9):1076-91.
2009: Tom D Bunney; Olaniyi Opaleye; S Mark Roe; Petra Vatter; Rhona W Baxendale; Claudia Walliser; Katy L Everett; Michelle Josephs; Carolin Christow; Fernando Rodrigues-Lima; Peter Gierschik; Laurence H Pearl; Matilda Katan
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
Molecular cell 2009;34(2):223-33.
2009: Natalia Lamuño Gandarillas; Tom D Bunney; Michelle Josephs; Peter Gierschik; Matilda Katan
In vitro reconstitution of activation of PLCepsilon by Ras and Rho GTPases.
Methods in molecular biology (Clifton, N.J.) 2009;462():379-89.
2008: Claudia Walliser; Michael Retlich; Richard Harris; Katy L Everett; Michelle B Josephs; Petra Vatter; Diego Esposito; Paul C Driscoll; Matilda Katan; Peter Gierschik; Tom D Bunney
rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain.
The Journal of biological chemistry 2008;283(44):30351-62.
2008: Barbara Moepps; Calogero Tulone; Claudia Kern; Rosalba Minisini; Gudrun Michels; Petra Vatter; Thomas Wieland; Peter Gierschik
Constitutive serum response factor activation by the viral chemokine receptor homologue pUS28 is differentially regulated by Galpha(q/11) and Galpha(16).
Cellular signalling 2008;20(8):1528-37.
2006: Ute Dreissigacker; Meike S Mueller; Monika Unger; Patrizia Siegert; Felicitas Genze; Peter Gierschik; Klaudia Giehl
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Cellular signalling 2006;18(8):1156-68.
2006: Barbara Moepps; Elke Nuesseler; Mike Braun; Peter Gierschik
A homolog of the human chemokine receptor CXCR1 is expressed in the mouse.
Molecular immunology 2006;43(7):897-914.
2006: Tom D Bunney; Richard Harris; Natalia Lamuño Gandarillas; Michelle Josephs; S Mark Roe; S Caroline Sorli; Hugh F Paterson; Fernando Rodrigues-Lima; Diego Esposito; Chris P Ponting; Peter Gierschik; Laurence H Pearl; Paul C Driscoll; Matilda Katan
Structural and mechanistic insights into ras association domains of phospholipase C epsilon.
Molecular cell 2006;21(4):495-507.
2006: Elena Palmesino; Barbara Moepps; Peter Gierschik; Marcus Thelen
Differences in CXCR4-mediated signaling in B cells.
Immunobiology 2006;211(5):377-89.
2005: Petra Vatter; Claudia Stoesser; Ines Samel; Peter Gierschik; Barbara Moepps
The variable C-terminal extension of G-protein-coupled receptor kinase 6 constitutes an accessorial autoregulatory domain.
The FEBS journal 2005;272(23):6039-51.
2005: Veysel Odemis; Elke Lamp; Gita Pezeshki; Barbara Moepps; Karl Schilling; Peter Gierschik; Dan R Littman; Jürgen Engele
Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis.
Molecular and cellular neurosciences 2005;30(4):494-505.
2005: Thomas Piechulek; Tobias Rehlen; Claudia Walliser; Petra Vatter; Barbara Moepps; Peter Gierschik
Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases.
The Journal of biological chemistry 2005;280(47):38923-31.
2005: Alma Zernecke; Andreas Schober; Ilze Bot; Philipp von Hundelshausen; Elisa A Liehn; Barbara Möpps; Mathias Mericskay; Peter Gierschik; Erik A L Biessen; Christian Weber
SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells.
Circulation research 2005;96(7):784-91.
2004: Christine Veit; Felicitas Genze; Andre Menke; Silke Hoeffert; Thomas M Gress; Peter Gierschik; Klaudia Giehl
Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells.
Cancer research 2004;64(15):5291-300.
2004: Patricia Ogilvie; Sylvia Thelen; Barbara Moepps; Peter Gierschik; Ana Claudia da Silva Campos; Marco Baggiolini; Marcus Thelen
Unusual chemokine receptor antagonism involving a mitogen-activated protein kinase pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):6715-22.
2004: Heiko Fensterer; Klaudia Giehl; Malte Buchholz; Volker Ellenrieder; Andreas Buck; Hans A Kestler; Guido Adler; Peter Gierschik; Thomas M Gress
Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1.
Genes, chromosomes & cancer 2004;39(3):224-35.
2004: Matthias D Hofer; Andre Menke; Felicitas Genze; Peter Gierschik; Klaudia Giehl
Expression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells.
British journal of cancer 2004;90(2):455-62.
2003: Alexander Dietrich; Alexander Scheer; Daria Illenberger; Yoel Kloog; Yoav I Henis; Peter Gierschik
Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit.
The Biochemical journal 2003;376(Pt 2):449-56.
2003: Martina Stähle; Christine Veit; Ulla Bachfischer; Karina Schierling; Bettina Skripczynski; Alan Hall; Peter Gierschik; Klaudia Giehl
Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK.
Journal of cell science 2003;116(Pt 18):3835-46.
2003: Martin Aepfelbacher; Claudia Trasak; Gottfried Wilharm; Agnès Wiedemann; Konrad Trulzsch; Kristina Krauss; Peter Gierschik; Jürgen Heesemann
Characterization of YopT effects on Rho GTPases in Yersinia enterocolitica-infected cells.
The Journal of biological chemistry 2003;278(35):33217-23.
2003: Rosalba Minisini; Calogero Tulone; Anke Lüske; Detlef Michel; Thomas Mertens; Peter Gierschik; Barbara Moepps
Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28.
Journal of virology 2003;77(8):4489-501.
2003: Daria Illenberger; Claudia Walliser; Joachim Strobel; Orit Gutman; Hagit Niv; Verena Gaidzik; Yoel Kloog; Peter Gierschik; Yoav I Henis
Rac2 regulation of phospholipase C-beta 2 activity and mode of membrane interactions in intact cells.
The Journal of biological chemistry 2003;278(10):8645-52.
2003: Daria Illenberger; Claudia Walliser; Bernd Nurnberg; Maria Diaz Lorente; Peter Gierschik
Specificity and structural requirements of phospholipase C-beta stimulation by Rho GTPases versus G protein beta gamma dimers.
The Journal of biological chemistry 2003;278(5):3006-14.
2002: Rosita Lupi; Nadia Dani; Alexander Dietrich; Adriano Marchegiani; Sabrina Turacchio; Christopher P Berrie; Joel Moss; Peter Gierschik; Daniela Corda; Maria Di Girolamo
Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors.
The Biochemical journal 2002;367(Pt 3):825-32.
2002: Veysel Odemis; Barbara Moepps; Peter Gierschik; Jürgen Engele
Interleukin-6 and cAMP induce stromal cell-derived factor-1 chemotaxis in astroglia by up-regulating CXCR4 cell surface expression. Implications for brain inflammation.
The Journal of biological chemistry 2002;277(42):39801-8.
2002: Mike Braun; Markus Wunderlin; Kathrin Spieth; Walter Knöchel; Peter Gierschik; Barbara Moepps
Xenopus laevis Stromal cell-derived factor 1: conservation of structure and function during vertebrate development.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(5):2340-7.
2000: Barbara Moepps; Mike Braun; K Knöpfle; Karin Dillinger; Walter Knöchel; Peter Gierschik
Characterization of a Xenopus laevis CXC chemokine receptor 4: implications for hematopoietic cell development in the vertebrate embryo.
European journal of immunology 2000;30(10):2924-34.
2000: Klaudia Giehl; Bjoern Seidel; Peter Gierschik; Guido Adler; Andre Menke
TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation.
Oncogene 2000;19(39):4531-41.
2000: Klaudia Giehl; B Skripczynski; A Mansard; Andre Menke; Peter Gierschik
Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration.
Oncogene 2000;19(25):2930-42.
2000: U Maier; A Babich; Nathalie Macrez; D Leopoldt; Peter Gierschik; Daria Illenberger; Bernd Nurnberg
Gbeta 5gamma 2 is a highly selective activator of phospholipid-dependent enzymes.
The Journal of biological chemistry 2000;275(18):13746-54.
2000: Klaus Scheffzek; I Stephan; O N Jensen; Daria Illenberger; Peter Gierschik
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.
Nature structural biology 2000;7(2):122-6.
2000: Daria Illenberger; I Stephan; Peter Gierschik; F Schwald
Stimulation of phospholipase C-beta 2 by Rho GTPases.
Methods in enzymology 2000;325():167-77.
1999: Barbara Moepps; Petra Vatter; R Frodl; F Waechter; C Dixkens; Horst Hameister; Peter Gierschik
Alternative splicing produces transcripts encoding four variants of mouse G-protein-coupled receptor kinase 6.
Genomics 1999;60(2):199-209.
1999: boaz weisz; Klaudia Giehl; Mali Gana-Weisz; Yaakov Egozi; Gilad Ben-Baruch; Daniele Marciano; Peter Gierschik; Yoel Kloog
A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice.
Oncogene 1999;18(16):2579-88.
1998: Daria Illenberger; F Schwald; D Pimmer; W Binder; G Maier; A Dietrich; Peter Gierschik
Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.
The EMBO journal 1998;17(21):6241-9.
1998: C Berndt; B Möpps; S Angermüller; Peter Gierschik; P H Krammer
CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12556-61.
1998: R Frodl; Peter Gierschik; Barbara Moepps
Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues.
Journal of receptor and signal transduction research 1998;18(4-6):321-44.
1997: Albrecht Piiper; D Stryjek-Kaminska; Daria Illenberger; R Klengel; J M Schmidt; Peter Gierschik; Stefan Zeuzem
Synthetic peptides containing a BXBXXXB(B) motif activate phospholipase C-beta1.
The Biochemical journal 1997;326 ( Pt 3)():669-74.
1997: Barbara Moepps; R Frodl; Hans-Reimer Rodewald; Marco Baggiolini; Peter Gierschik
Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1alpha activation of Gi2 are differentially expressed in vivo.
European journal of immunology 1997;27(8):2102-12.
1997: Daria Illenberger; F Schwald; Peter Gierschik
Characterization and purification from bovine neutrophils of a soluble guanine-nucleotide-binding protein that mediates isozyme-specific stimulation of phospholipase C beta2.
European journal of biochemistry / FEBS 1997;246(1):71-7.
1996: A Dietrich; Derek Brazil; O N Jensen; Michael Meister; M Schrader; J F Moomaw; M Mann; Daria Illenberger; Peter Gierschik
Isoprenylation of the G protein gamma subunit is both necessary and sufficient for beta gamma dimer-mediated stimulation of phospholipase C.
Biochemistry 1996;35(48):15174-82.
1996: J Kelly; Derek Brazil; C Clyne; N G McHale; Peter Gierschik; AK Keenan
Evidence for the presence of G-proteins, adenylyl cyclase and phospholipase C activities in lymphatic smooth muscle cell membranes.
Cellular signalling 1996;8(6):425-32.
1995: Michael Meister; A Dietrich; Peter Gierschik
Identification of a three-amino-acid region in G protein gamma 1 as a determinant of selective beta gamma heterodimerization.
European journal of biochemistry / FEBS 1995;234(1):171-7.
1995: A P Simões; M Camps; P Schnabel; Peter Gierschik
Mutational analysis of a putative polyphosphoinositide binding site in phospholipase C-beta 2.
FEBS letters 1995;365(2-3):155-8.
1995: A P Simões; Jennifer Reed; P Schnabel; M Camps; Peter Gierschik
Characterization of putative polyphosphoinositide binding motifs from phospholipase C beta 2.
Biochemistry 1995;34(15):5113-9.
1995: A Scheer; Peter Gierschik
S-prenylated cysteine analogues inhibit receptor-mediated G protein activation in native human granulocyte and reconstituted bovine retinal rod outer segment membranes.
Biochemistry 1995;34(15):4952-61.
1994: A Dietrich; Michael Meister; Derek Brazil; M Camps; Peter Gierschik
Stimulation of phospholipase C-beta 2 by recombinant guanine-nucleotide-binding protein beta gamma dimers produced in a baculovirus/insect cell expression system. Requirement of gamma-subunit isoprenylation for stimulation of phospholipase C.
European journal of biochemistry / FEBS 1994;219(1-2):171-8.
1994: Peter Gierschik; T Bouillon; K H Jakobs
Receptor-stimulated hydrolysis of guanosine 5'-triphosphate in membrane preparations.
Methods in enzymology 1994;237():13-26.
1994: Peter Gierschik; M Camps
Stimulation of phospholipase C by G-protein beta gamma subunits.
Methods in enzymology 1994;238():181-95.
1993: P Schnabel; M Camps; A Carozzi; Peter J Parker; Peter Gierschik
Mutational analysis of phospholipase C-beta 2. Identification of regions required for membrane association and stimulation by guanine-nucleotide-binding protein beta gamma subunits.
European journal of biochemistry / FEBS 1993;217(3):1109-15.
1993: A P Simões; P Schnabel; R Pipkorn; M Camps; Peter Gierschik
A peptide corresponding to a potential polyphosphoinositide binding site of phospholipase C-beta 2 enhances its catalytic activity.
FEBS letters 1993;331(3):248-51.
1993: A Scheer; Peter Gierschik
Farnesylcysteine analogues inhibit chemotactic peptide receptor-mediated G-protein activation in human HL-60 granulocyte membranes.
FEBS letters 1993;319(1-2):110-4.
1993: A Carozzi; M Camps; Peter Gierschik; Peter J Parker
Activation of phosphatidylinositol lipid-specific phospholipase C-beta 3 by G-protein beta gamma subunits.
FEBS letters 1993;315(3):340-2.
1992: M Camps; A Carozzi; P Schnabel; A Scheer; Peter J Parker; Peter Gierschik
Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.
Nature 1992;360(6405):684-6.
1992: A Dietrich; Michael Meister; K Spicher; G Schultz; M Camps; Peter Gierschik
Expression, characterization and purification of soluble G-protein beta gamma dimers composed of defined subunits in baculovirus-infected insect cells.
FEBS letters 1992;313(3):220-4.
1992: P Schnabel; R Schreck; D L Schiller; M Camps; Peter Gierschik
Stimulation of phospholipase C by a mutationally activated G protein alpha 16 subunit.
Biochemical and biophysical research communications 1992;188(3):1018-23.
1992: H Heithier; M Fröhlich; Christian Dees; M Baumann; M Häring; Peter Gierschik; E Schiltz; W L Vaz; M Hekman; E J Helmreich
Subunit interactions of GTP-binding proteins.
European journal of biochemistry / FEBS 1992;204(3):1169-81.
1987: M Hekman; A Holzhöfer; Peter Gierschik; M J Im; K H Jakobs; T Pfeuffer; E J Helmreich
Regulation of signal transfer from beta 1-adrenoceptor to adenylate cyclase by beta gamma subunits in a reconstituted system.
European journal of biochemistry / FEBS 1987;169(2):431-9.
1987: M J Im; A Holzhöfer; AK Keenan; Peter Gierschik; M Hekman; E J Helmreich; T Pfeuffer
The role of beta, gamma-subunits of guanine nucleotide binding proteins in control of a reconstituted signal transmission chain containing purified components of the adenylate cyclase system.
Journal of receptor research 1987;7(1-4):17-42.