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John Gierthy

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Chemicals & Drugs

Disorders

Anatomy

Tumor Cells, Cultured

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Hydroxylation

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Publications

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Katerina D Fagan-Solis; John F Gierthy; Christopher N Otis; Brian T Pentecost; Sallie Smith Schneider; Brook A Bentley; Kathleen F Arcaro
The RhoA pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line.
Laurie M Bradley; John F Gierthy; Brian T Pentecost
Role of the insulin-like growth factor system on an estrogen-dependent cancer phenotype in the MCF-7 human breast cancer cell line.
Lydia G Marquez-Bravo; John F Gierthy
Differential expression of estrogen receptor alpha (ERalpha) protein in MCF-7 breast cancer cells chronically exposed to TCDD.

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All Publications

2013: Katerina D Fagan-Solis; John F Gierthy; Christopher N Otis; Brian T Pentecost; Sallie Smith Schneider; Brook A Bentley; Kathleen F Arcaro
The RhoA pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line.
Journal of cellular biochemistry 2013;114(6):1385-94.
2008: Laurie M Bradley; John F Gierthy; Brian T Pentecost
Role of the insulin-like growth factor system on an estrogen-dependent cancer phenotype in the MCF-7 human breast cancer cell line.
The Journal of steroid biochemistry and molecular biology 2008;109(1-2):185-96.
2008: Lydia G Marquez-Bravo; John F Gierthy
Differential expression of estrogen receptor alpha (ERalpha) protein in MCF-7 breast cancer cells chronically exposed to TCDD.
Journal of cellular biochemistry 2008;103(2):636-47.
2006: Barbara C Spink; Richard W Cole; Barbara H Katz; John F Gierthy; Laurie M Bradley; David C Spink
Inhibition of MCF-7 breast cancer cell proliferation by MCF-10A breast epithelial cells in coculture.
Cell biology international 2006;30(3):227-38.
2005: Brian T Pentecost; L M Bradley; John F Gierthy; Y Ding; Michael J Fasco
Gene regulation in an MCF-7 cell line that naturally expresses an estrogen receptor unable to directly bind DNA.
Molecular and cellular endocrinology 2005;238(1-2):9-25.
2005: Olga A Sukocheva; Yi Yang; John F Gierthy; Richard F Seegal
Methyl mercury influences growth-related signaling in MCF-7 breast cancer cells.
Environmental toxicology 2005;20(1):32-44.
2004: Simon Spivack; Gregory J Hurteau; Ritu Jain; Shalini V Kumar; Kenneth M Aldous; John F Gierthy; Laurence S Kaminsky
Gene-environment interaction signatures by quantitative mRNA profiling in exfoliated buccal mucosal cells.
Cancer research 2004;64(18):6805-13.
2003: Michael J Fasco; Agita Amin; Brian T Pentecost; Yi Yang; John F Gierthy
Phenotypic changes in MCF-7 cells during prolonged exposure to tamoxifen.
Molecular and cellular endocrinology 2003;206(1-2):33-47.
2002: John F Gierthy
Testing for endocrine disruption: how much is enough?
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):1-3.
2002: James A Bennett; Fassil B Mesfin; Thomas T Andersen; John F Gierthy; Herbert I Jacobson
A peptide derived from alpha-fetoprotein prevents the growth of estrogen-dependent human breast cancers sensitive and resistant to tamoxifen.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2211-5.
2001: Kathleen F Arcaro; John F Gierthy; Carl R Mackerer
Antiestrogenicity of clarified slurry oil and two crude oils in a human breast-cancer cell assay.
Journal of toxicology and environmental health. Part A 2001;62(7):505-21.
2001: Kathleen F Arcaro; John F Gierthy
Assessing modulation of estrogenic activity of environmental and pharmaceutical compounds using MCF-7 focus assay.
Methods in molecular biology (Clifton, N.J.) 2001;176():341-51.
2000: Barbara C Spink; Barbara H Katz; Mirza M Hussain; S Pang; S P Connor; Kenneth M Aldous; John F Gierthy; David C Spink
SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells.
Carcinogenesis 2000;21(11):1947-57.
2000: David C Spink; Barbara C Spink; Xiaoliang Zhuo; Mirza M Hussain; John F Gierthy; Xinxin Ding
NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1.
The Journal of steroid biochemistry and molecular biology 2000;74(1-2):11-8.
2000: Michael J Fasco; Khandan Keyomarsi; Kathleen F Arcaro; John F Gierthy
Expression of an estrogen receptor alpha variant protein in cell lines and tumors.
Molecular and cellular endocrinology 2000;166(2):156-69.
2000: Michael J Fasco; Khandan Keyomarsi; Kathleen F Arcaro; John F Gierthy
Expression of an estrogen receptor alpha variant protein in cell lines and tumors.
Molecular and cellular endocrinology 2000;162(1-2):167-80.
2000: DD Vakharia; John F Gierthy
Use of a combined human liver microsome-estrogen receptor binding assay to assess potential estrogen modulating activity of PCB metabolites.
Toxicology letters 2000;114(1-3):55-65.
2000: Kathleen F Arcaro; Y Yang; DD Vakharia; John F Gierthy
Toxaphene is antiestrogenic in a human breast-cancer cell assay.
Journal of toxicology and environmental health. Part A 2000;59(3):197-210.
1999: Kathleen F Arcaro; Y Yang; John F Gierthy
Benzo[k]fluoranthene enhancement and suppression of 17beta-estradiol catabolism in MCF-7 breast cancer cells.
Journal of toxicology and environmental health. Part A 1999;58(7):413-26.
1999: Kathleen F Arcaro; Patrick W O'Keefe; Y Yang; William C Clayton; John F Gierthy
Antiestrogenicity of environmental polycyclic aromatic hydrocarbons in human breast cancer cells.
Toxicology 1999;133(2-3):115-27.
1999: DD Vakharia; John F Gierthy
Rapid assay for oestrogen receptor binding to PCB metabolites.
Toxicology in vitro : an international journal published in association with BIBRA 1999;13(2):275-82.
1999: Kathleen F Arcaro; L Yi; Richard F Seegal; DD Vakharia; Y Yang; David C Spink; Karl O Brosch; John F Gierthy
2,2',6,6'-Tetrachlorobiphenyl is estrogenic in vitro and in vivo.
Journal of cellular biochemistry 1999;72(1):94-102.
1998: Barbara C Spink; Michael J Fasco; John F Gierthy; David C Spink
12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.
Journal of cellular biochemistry 1998;70(3):289-96.
1998: Kathleen F Arcaro; DD Vakharia; Y Yang; John F Gierthy
Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides.
Environmental health perspectives 1998;106 Suppl 4():1041-6.
1997: David C Spink; Barbara C Spink; JQ Cao; John F Gierthy; CL Hayes; Yu Li; Thomas R Sutter
Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN human renal adenocarcinoma cells.
The Journal of steroid biochemistry and molecular biology 1997;62(2-3):223-32.
1997: John F Gierthy; Kathleen F Arcaro; M Floyd
Assessment of PCB estrogenicity in a human breast cancer cell line.
Chemosphere 1997;34(5-7):1495-505.
1996: John F Gierthy; Barbara C Spink; H L Figge; B T Pentecost; David C Spink
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17 beta-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells.
Journal of cellular biochemistry 1996;60(2):173-84.
1994: David C Spink; CL Hayes; N R Young; M Christou; Thomas R Sutter; Colin R Jefcoate; John F Gierthy
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17 beta-estradiol 4-hydroxylase.
The Journal of steroid biochemistry and molecular biology 1994;51(5-6):251-8.
1994: Joseph A Depasquale; W A Samsonoff; John F Gierthy
17-beta-Estradiol induced alterations of cell-matrix and intercellular adhesions in a human mammary carcinoma cell line.
Journal of cell science 1994;107 ( Pt 5)():1241-54.
1994: M Christou; U Savas; David C Spink; John F Gierthy; Colin R Jefcoate
Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells.
Carcinogenesis 1994;15(4):725-32.
1994: David C Spink; J A Johnson; S P Connor; K M Aldous; John F Gierthy
Stimulation of 17 beta-estradiol metabolism in MCF-7 cells by bromochloro- and chloromethyl-substituted dibenzo-p-dioxins and dibenzofurans: correlations with antiestrogenic activity.
Journal of toxicology and environmental health 1994;41(4):451-66.
1994: John F Gierthy; J B Silkworth; M Tassinari; G S Stein; J B Lian
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits differentiation of normal diploid rat osteoblasts in vitro.
Journal of cellular biochemistry 1994;54(2):231-8.
1993: John F Gierthy; J A Bennett; L M Bradley; D S Cutler
Correlation of in vitro and in vivo growth suppression of MCF-7 human breast cancer by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Cancer research 1993;53(13):3149-53.
1992: David C Spink; H P Eugster; D W Lincoln; John D Schuetz; Erin G Schuetz; J A Johnson; Laurence S Kaminsky; John F Gierthy
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA.
Archives of biochemistry and biophysics 1992;293(2):342-8.
1991: John F Gierthy; D W Lincoln; K E Roth; S S Bowser; J A Bennett; L Bradley; H W Dickerman
Estrogen-stimulation of postconfluent cell accumulation and foci formation of human MCF-7 breast cancer cells.
Journal of cellular biochemistry 1991;45(2):177-87.
1990: David C Spink; D W Lincoln; H W Dickerman; John F Gierthy
2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6917-21.
1988: John F Gierthy; D W Lincoln; S J Kampcik; H W Dickerman; H Leon Bradlow; T Niwa; G E Swaneck
Enhancement of 2- and 16 alpha-estradiol hydroxylation in MCF-7 human breast cancer cells by 2,3,7,8-tetrachlorodibenzo-P-dioxin.
Biochemical and biophysical research communications 1988;157(2):515-20.
1988: Michael J Fasco; G E Eagan; A C Wilson; John F Gierthy; D L Lincoln
Loss of metastatic and primary tumor factor X activator capabilities by Lewis lung carcinoma cells cultured in vitamin K-dependent protein deficient serum.
Cancer research 1988;48(22):6504-9.
1988: John F Gierthy; D W Lincoln
Inhibition of postconfluent focus production in cultures of MCF-7 human breast cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Breast cancer research and treatment 1988;12(2):227-33.
1987: D W Lincoln; S J Kampcik; John F Gierthy
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) does not inhibit intercellular communication in Chinese hamster V79 cells.
Carcinogenesis 1987;8(12):1817-20.
1987: John F Gierthy; D W Lincoln; M B Gillespie; J I Seeger; H L Martinez; H W Dickerman; S A Kumar
Suppression of estrogen-regulated extracellular tissue plasminogen activator activity of MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Cancer research 1987;47(23):6198-203.
1987: M J Fasco; A C Wilson; D Lincoln; John F Gierthy
Evidence for a warfarin-sensitive serum factor that participates in factor X activation by Lewis lung tumor cells.
International journal of cancer. Journal international du cancer 1987;39(5):631-7.
1987: Michael J Fasco; A C Wilson; R G Briggs; John F Gierthy
Identification of vitamin K1 chromenol--a novel metabolite of vitamin K1 formed in vitro by a component in blood.
Archives of biochemistry and biophysics 1987;252(2):501-6.
1987: Anthony P Decaprio; R Briggs; John F Gierthy; J C Kim; R D Kleopfer
Acute toxicity in the guinea pig and in vitro "dioxin-like" activity of the environmental contaminant 1,2,4,5,7,8-hexachloro (9H)xanthene.
Journal of toxicology and environmental health 1987;20(3):241-8.
1986: G Eadon; Laurence S Kaminsky; J Silkworth; K Aldous; D Hilker; Patrick W O'Keefe; R Smith; John F Gierthy; J Hawley; N Kim
Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures.
Environmental health perspectives 1986;70():221-7.
1985: Patrick W O'Keefe; J B Silkworth; John F Gierthy; R M Smith; Anthony P Decaprio; J N Turner; G Eadon; D R Hilker; K M Aldous; Laurence S Kaminsky
Chemical and biological investigations of a transformer accident at Binghamton, NY.
Environmental health perspectives 1985;60():201-9.