Harry Gilbert

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Abbott D Wade; Ficko-Blean Elizabeth; van Bueren Alicia Lammerts; Rogowski Artur; Cartmell Alan; Coutinho Pedro M; Henrissat Bernard; Gilbert Harry J; Boraston Alisdair B
Analysis of the structural and functional diversity of plant cell wall specific family 6 carbohydrate binding modules.
Correia Márcia A S; Pires Virgínia M R; Gilbert Harry J; Bolam David N; Fernandes Vânia O; Alves Victor D; Prates José A M; Ferreira Luís M A; Fontes Carlos M G A
Family 6 carbohydrate-binding modules display multiple beta1,3-linked glucan-specific binding interfaces.
Verhertbruggen Yves; Marcus Susan E; Haeger Ash; Verhoef René; Schols Henk A; McCleary Barry V; McKee Lauren; Gilbert Harry J; Knox J Paul
Developmental complexity of arabinan polysaccharides and their processing in plant cell walls.

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All Publications

2009: Abbott D Wade; Ficko-Blean Elizabeth; van Bueren Alicia Lammerts; Rogowski Artur; Cartmell Alan; Coutinho Pedro M; Henrissat Bernard; Gilbert Harry J; Boraston Alisdair B
Analysis of the structural and functional diversity of plant cell wall specific family 6 carbohydrate binding modules.
Biochemistry 2009;48(43):10395-404.
2009: Correia Márcia A S; Pires Virgínia M R; Gilbert Harry J; Bolam David N; Fernandes Vânia O; Alves Victor D; Prates José A M; Ferreira Luís M A; Fontes Carlos M G A
Family 6 carbohydrate-binding modules display multiple beta1,3-linked glucan-specific binding interfaces.
FEMS microbiology letters 2009;300(1):48-57.
2009: Verhertbruggen Yves; Marcus Susan E; Haeger Ash; Verhoef René; Schols Henk A; McCleary Barry V; McKee Lauren; Gilbert Harry J; Knox J Paul
Developmental complexity of arabinan polysaccharides and their processing in plant cell walls.
The Plant journal : for cell and molecular biology 2009;59(3):413-25.
2009: Tailford Louise E; Ducros Valerie M-A; Flint James E; Roberts Shirley M; Morland Carl; Zechel David L; Smith Nicola; Bjørnvad Mads E; Borchert Torben V; Wilson Keith S; Davies Gideon J; Gilbert Harry J
Understanding how diverse beta-mannanases recognize heterogeneous substrates.
Biochemistry 2009;48(29):7009-18.
2009: Offen Wendy A; Zechel David L; Withers Stephen G; Gilbert Harry J; Davies Gideon J
Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.
Chemical communications (Cambridge, England) 2009;(18):2484-6.
2009: Hervé Cécile; Rogowski Artur; Gilbert Harry J; Paul Knox J
Enzymatic treatments reveal differential capacities for xylan recognition and degradation in primary and secondary plant cell walls.
The Plant journal : for cell and molecular biology 2009;58(3):413-22.
2009: Montanier Cedric; Money Victoria A; Pires Virginia M R; Flint James E; Pinheiro Benedita A; Goyal Arun; Prates José A M; Izumi Atsushi; Stålbrand Henrik; Morland Carl; Cartmell Alan; Kolenova Katarina; Topakas Evangelos; Dodson Eleanor J; Bolam David N; Davies Gideon J; Fontes Carlos M G A; Gilbert Harry J
The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions.
PLoS biology 2009;7(3):e71.
2009: Montanier Cedric; van Bueren Alicia Lammerts; Dumon Claire; Flint James E; Correia Marcia A; Prates Jose A; Firbank Susan J; Lewis Richard J; Grondin Gilles G; Ghinet Mariana G; Gloster Tracey M; Herve Cecile; Knox J Paul; Talbot Brian G; Turkenburg Johan P; Kerovuo Janne; Brzezinski Ryszard; Fontes Carlos M G A; Davies Gideon J; Boraston Alisdair B; Gilbert Harry J
Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3065-70.
2009: Emami Kaveh; Topakas Evangelos; Nagy Tibor; Henshaw Joanna; Jackson Kelly A; Nelson Karen E; Mongodin Emmanuel F; Murray James W; Lewis Richard J; Gilbert Harry J
Regulation of the xylan-degrading apparatus of Cellvibrio japonicus by a novel two-component system.
The Journal of biological chemistry 2009;284(2):1086-96.
2008: Cartmell Alan; Topakas Evangelos; Ducros Valérie M-A; Suits Michael D L; Davies Gideon J; Gilbert Harry J
The Cellvibrio japonicus mannanase CjMan26C displays a unique exo-mode of action that is conferred by subtle changes to the distal region of the active site.
The Journal of biological chemistry 2008;283(49):34403-13.
2008: DeBoy Robert T; Mongodin Emmanuel F; Fouts Derrick E; Tailford Louise E; Khouri Hoda; Emerson Joanne B; Mohamoud Yasmin; Watkins Kisha; Henrissat Bernard; Gilbert Harry J; Nelson Karen E
Insights into plant cell wall degradation from the genome sequence of the soil bacterium Cellvibrio japonicus.
Journal of bacteriology 2008;190(15):5455-63.
2008: Dumon Claire; Varvak Alexander; Wall Mark A; Flint James E; Lewis Richard J; Lakey Jeremy H; Morland Carl; Luginbühl Peter; Healey Shaun; Todaro Thomas; DeSantis Grace; Sun May; Parra-Gessert Lilian; Tan Xuqiu; Weiner David P; Gilbert Harry J
Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure.
The Journal of biological chemistry 2008;283(33):22557-64.
2008: Gilbert Harry John
Sus out sugars in.
Structure (London, England : 1993) 2008;16(7):987-9.
2008: Pinheiro Benedita A; Proctor Mark R; Martinez-Fleites Carlos; Prates José A M; Money Victoria A; Davies Gideon J; Bayer Edward A; Fontesm Carlos M G A; Fierobe Henri-Pierre; Gilbert Harry J
The Clostridium cellulolyticum dockerin displays a dual binding mode for its cohesin partner.
The Journal of biological chemistry 2008;283(26):18422-30.
2008: Gilbert Harry J; Stålbrand Henrik; Brumer Harry
How the walls come crumbling down: recent structural biochemistry of plant polysaccharide degradation.
Current opinion in plant biology 2008;11(3):338-48.
2008: Weiner Ronald M; Taylor Larry E; Henrissat Bernard; Hauser Loren; Land Miriam; Coutinho Pedro M; Rancurel Corinne; Saunders Elizabeth H; Longmire Atkinson G; Zhang Haitao; Bayer Edward A; Gilbert Harry J; Larimer Frank; Zhulin Igor B; Ekborg Nathan A; Lamed Raphael; Richardson Paul M; Borovok Ilya; Hutcheson Steven
Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T.
PLoS genetics 2008;4(5):e1000087.
2008: Correia Márcia A S; Prates José A M; Brás Joana; Fontes Carlos M G A; Newman Joseph A; Lewis Richard J; Gilbert Harry J; Flint James E
Crystal structure of a cellulosomal family 3 carbohydrate esterase from Clostridium thermocellum provides insights into the mechanism of substrate recognition.
Journal of molecular biology 2008;379(1):64-72.
2008: Tailford Louise E; Offen Wendy A; Smith Nicola L; Dumon Claire; Morland Carl; Gratien Julie; Heck Marie-Pierre; Stick Robert V; Blériot Yves; Vasella Andrea; Gilbert Harry J; Davies Gideon J
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.
Nature chemical biology 2008;4(5):306-12.
2008: Money Victoria A; Cartmell Alan; Guerreiro Catarina I P D; Ducros Valerie M-A; Fontes Carlos M G A; Gilbert Harry J; Davies Gideon J
Probing the beta-1,3:1,4 glucanase, CtLic26A, with a thio-oligosaccharide and enzyme variants.
Organic & biomolecular chemistry 2008;6(5):851-3.
2008: Vardakou Maria; Dumon Claire; Murray James W; Christakopoulos Paul; Weiner David P; Juge Nathalie; Lewis Richard J; Gilbert Harry J; Flint James E
Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases.
Journal of molecular biology 2008;375(5):1293-305.
2007: Nagy Tibor; Tunnicliffe Richard B; Higgins Lee D; Walters Chris; Gilbert Harry J; Williamson Mike P
Characterization of a double dockerin from the cellulosome of the anaerobic fungus Piromyces equi.
Journal of molecular biology 2007;373(3):612-22.
2007: Obembe Olawole O; Jacobsen Evert; Timmers Jaap; Gilbert Harry; Blake Anthony W; Knox J Paul; Visser Richard G F; Vincken Jean-Paul
Promiscuous, non-catalytic, tandem carbohydrate-binding modules modulate the cell-wall structure and development of transgenic tobacco (Nicotiana tabacum) plants.
Journal of plant research 2007;120(5):605-17.
2007: Cicortas Gunnarsson Lavinia; Montanier Cedric; Tunnicliffe Richard B; Williamson Mike P; Gilbert Harry J; Nordberg Karlsson Eva; Ohlin Mats
Novel xylan-binding properties of an engineered family 4 carbohydrate-binding module.
The Biochemical journal 2007;406(2):209-14.
2007: Tailford Louise E; Money Victoria A; Smith Nicola L; Dumon Claire; Davies Gideon J; Gilbert Harry J
Mannose foraging by Bacteroides thetaiotaomicron: structure and specificity of the beta-mannosidase, BtMan2A.
The Journal of biological chemistry 2007;282(15):11291-9.
2007: Bolam David N; Roberts Shirley; Proctor Mark R; Turkenburg Johan P; Dodson Eleanor J; Martinez-Fleites Carlos; Yang Min; Davis Benjamin G; Davies Gideon J; Gilbert Harry J
The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5336-41.
2007: Gilbert Harry J
Cellulosomes: microbial nanomachines that display plasticity in quaternary structure.
Molecular microbiology 2007;63(6):1568-76.
2007: Carvalho Ana Luísa; Dias Fernando M V; Nagy Tibor; Prates José A M; Proctor Mark R; Smith Nicola; Bayer Edward A; Davies Gideon J; Ferreira Luís M A; Romão Maria J; Fontes Carlos M G A; Gilbert Harry J
Evidence for a dual binding mode of dockerin modules to cohesins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3089-94.
2006: Centeno Maria S J; Goyal Arun; Prates José A M; Ferreira Luís M A; Gilbert Harry J; Fontes Carlos M G A
Novel modular enzymes encoded by a cellulase gene cluster in Cellvibrio mixtus.
FEMS microbiology letters 2006;265(1):26-34.
2006: Martinez-Fleites Carlos; Proctor Mark; Roberts Shirley; Bolam David N; Gilbert Harry J; Davies Gideon J
Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4.
Chemistry & biology 2006;13(11):1143-52.
2006: Blake Anthony W; McCartney Lesley; Flint James E; Bolam David N; Boraston Alisdair B; Gilbert Harry J; Knox J Paul
Understanding the biological rationale for the diversity of cellulose-directed carbohydrate-binding modules in prokaryotic enzymes.
The Journal of biological chemistry 2006;281(39):29321-9.
2006: Centeno Maria S J; Guerreiro Catarina I P D; Dias Fernando M V; Morland Carl; Tailford Louise E; Goyal Arun; Prates José A M; Ferreira Luís M A; Caldeira Rui M H; Mongodin Emmanuel F; Nelson Karen E; Gilbert Harry J; Fontes Carlos M G A
Galactomannan hydrolysis and mannose metabolism in Cellvibrio mixtus.
FEMS microbiology letters 2006;261(1):123-32.
2006: Money Victoria A; Smith Nicola L; Scaffidi Adrian; Stick Robert V; Gilbert Harry J; Davies Gideon J
Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases.
Angewandte Chemie (International ed. in English) 2006;45(31):5136-40.
2006: Xie Hefang; Flint James; Vardakou Maria; Lakey Jeremy H; Lewis Richard J; Gilbert Harry J; Dumon Claire
Probing the structural basis for the difference in thermostability displayed by family 10 xylanases.
Journal of molecular biology 2006;360(1):157-67.
2006: Henshaw Joanna; Horne-Bitschy Ami; van Bueren Alicia Lammerts; Money Victoria A; Bolam David N; Czjzek Mirjam; Ekborg Nathan A; Weiner Ronald M; Hutcheson Steven W; Davies Gideon J; Boraston Alisdair B; Gilbert Harry J
Family 6 carbohydrate binding modules in beta-agarases display exquisite selectivity for the non-reducing termini of agarose chains.
The Journal of biological chemistry 2006;281(25):17099-107.
2006: Barton Christopher J; Tailford Louise E; Welchman Helen; Zhang Zhinong; Gilbert Harry J; Dupree Paul; Goubet Florence
Enzymatic fingerprinting of Arabidopsis pectic polysaccharides using polysaccharide analysis by carbohydrate gel electrophoresis (PACE).
Planta 2006;224(1):163-74.
2006: Taylor Edward J; Smith Nicola L; Turkenburg Johan P; D'Souza Simone; Gilbert Harry J; Davies Gideon J
Structural insight into the ligand specificity of a thermostable family 51 arabinofuranosidase, Araf51, from Clostridium thermocellum.
The Biochemical journal 2006;395(1):31-7.
2006: McCartney Lesley; Blake Anthony W; Flint James; Bolam David N; Boraston Alisdair B; Gilbert Harry J; Knox J Paul
Differential recognition of plant cell walls by microbial xylan-specific carbohydrate-binding modules.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4765-70.
2006: Najmudin Shabir; Guerreiro Catarina I P D; Carvalho Ana L; Prates José A M; Correia Márcia A S; Alves Victor D; Ferreira Luís M A; Romão Maria J; Gilbert Harry J; Bolam David N; Fontes Carlos M G A
Xyloglucan is recognized by carbohydrate-binding modules that interact with beta-glucan chains.
The Journal of biological chemistry 2006;281(13):8815-28.
2005: Vardakou Maria; Flint James; Christakopoulos Paul; Lewis Richard J; Gilbert Harry J; Murray James W
A family 10 Thermoascus aurantiacus xylanase utilizes arabinose decorations of xylan as significant substrate specificity determinants.
Journal of molecular biology 2005;352(5):1060-7.
2005: Taylor Edward J; Goyal Arun; Guerreiro Catarina I P D; Prates José A M; Money Victoria A; Ferry Natalie; Morland Carl; Planas Antoni; Macdonald James A; Stick Robert V; Gilbert Harry J; Fontes Carlos M G A; Davies Gideon J
How family 26 glycoside hydrolases orchestrate catalysis on different polysaccharides: structure and activity of a Clostridium thermocellum lichenase, CtLic26A.
The Journal of biological chemistry 2005;280(38):32761-7.
2005: Yang Min; Proctor Mark R; Bolam David N; Errey James C; Field Robert A; Gilbert Harry J; Davis Benjamin G
Probing the breadth of macrolide glycosyltransferases: in vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency.
Journal of the American Chemical Society 2005;127(26):9336-7.
2005: Flint James; Taylor Edward; Yang Min; Bolam David N; Tailford Louise E; Martinez-Fleites Carlos; Dodson Eleanor J; Davis Benjamin G; Gilbert Harry J; Davies Gideon J
Structural dissection and high-throughput screening of mannosylglycerate synthase.
Nature structural & molecular biology 2005;12(7):608-14.
2005: Carvalho Ana L; Pires Virginia M R; Gloster Tracey M; Turkenburg Johan P; Prates José A M; Ferreira Luís M A; Romão Maria J; Davies Gideon J; Fontes Carlos M G A; Gilbert Harry J
Insights into the structural determinants of cohesin-dockerin specificity revealed by the crystal structure of the type II cohesin from Clostridium thermocellum SdbA.
Journal of molecular biology 2005;349(5):909-15.
2005: Flint James; Bolam David N; Nurizzo Didier; Taylor Edward J; Williamson Michael P; Walters Christopher; Davies Gideon J; Gilbert Harry J
Probing the mechanism of ligand recognition in family 29 carbohydrate-binding modules.
The Journal of biological chemistry 2005;280(25):23718-26.
2005: Varrot Annabelle; Leydier Sabine; Pell Gavin; Macdonald James M; Stick Robert V; Henrissat Bernard; Gilbert Harry J; Davies Gideon J
Mycobacterium tuberculosis strains possess functional cellulases.
The Journal of biological chemistry 2005;280(21):20181-4.
2005: Tunnicliffe Richard B; Bolam David N; Pell Gavin; Gilbert Harry J; Williamson Mike P
Structure of a mannan-specific family 35 carbohydrate-binding module: evidence for significant conformational changes upon ligand binding.
Journal of molecular biology 2005;347(2):287-96.
2005: Proctor Mark R; Taylor Edward J; Nurizzo Didier; Turkenburg Johan P; Lloyd Ruth M; Vardakou Maria; Davies Gideon J; Gilbert Harry J
Tailored catalysts for plant cell-wall degradation: redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2697-702.
2005: van Bueren Alicia Lammerts; Morland Carl; Gilbert Harry J; Boraston Alisdair B
Family 6 carbohydrate binding modules recognize the non-reducing end of beta-1,3-linked glucans by presenting a unique ligand binding surface.
The Journal of biological chemistry 2005;280(1):530-7.
2004: Andrews Simon R; Taylor Edward J; Pell Gavin; Vincent Florence; Ducros Valérie M-A; Davies Gideon J; Lakey Jeremy H; Gilbert Harry J
The use of forced protein evolution to investigate and improve stability of family 10 xylanases. The production of Ca2+-independent stable xylanases.
The Journal of biological chemistry 2004;279(52):54369-79.
2004: Vincent Florence; Gloster Tracey M; Macdonald James; Morland Carl; Stick Robert V; Dias Fernando M V; Prates José A M; Fontes Carlos M G A; Gilbert Harry J; Davies Gideon J
Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis.
Chembiochem : a European journal of chemical biology 2004;5(11):1596-9.
2004: Gilbert Harry J; O'Donnell Anthony G; Mathers John C
'Informative' horizontal gene transfer.
Nature biotechnology 2004;22(9):1076.
2004: Dias Fernando M V; Goyal Arun; Gilbert Harry J; José A M Prates; Ferreira Luís M A; Fontes Carlos M G A
The N-terminal family 22 carbohydrate-binding module of xylanase 10B of Clostridium themocellum is not a thermostabilizing domain.
FEMS microbiology letters 2004;238(1):71-8.
2004: Boraston Alisdair B; Bolam David N; Gilbert Harry J; Davies Gideon J
Carbohydrate-binding modules: fine-tuning polysaccharide recognition.
The Biochemical journal 2004;382(Pt 3):769-81.
2004: Carvalho Ana L; Goyal Arun; Prates José A M; Bolam David N; Gilbert Harry J; Pires Virgínia M R; Ferreira Luís M A; Planas Antoni; Romão Maria J; Fontes Carlos M G A
The family 11 carbohydrate-binding module of Clostridium thermocellum Lic26A-Cel5E accommodates beta-1,4- and beta-1,3-1,4-mixed linked glucans at a single binding site.
The Journal of biological chemistry 2004;279(33):34785-93.
2004: Payan Françoise; Leone Philippe; Porciero Sophie; Furniss Caroline; Tahir Tariq; Williamson Gary; Durand Anne; Manzanares Paloma; Gilbert Harry J; Juge Nathalie; Roussel Alain
The dual nature of the wheat xylanase protein inhibitor XIP-I: structural basis for the inhibition of family 10 and family 11 xylanases.
The Journal of biological chemistry 2004;279(34):36029-37.
2004: Dias Fernando M V; Vincent Florence; Pell Gavin; Prates José A M; Centeno Maria S J; Tailford Louise E; Ferreira Luís M A; Fontes Carlos M G A; Davies Gideon J; Gilbert Harry J
Insights into the molecular determinants of substrate specificity in glycoside hydrolase family 5 revealed by the crystal structure and kinetics of Cellvibrio mixtus mannosidase 5A.
The Journal of biological chemistry 2004;279(24):25517-26.
2004: Ji Qin; Oomen Ronald J F J; Vincken Jean-Paul; Bolam David N; Gilbert Harry J; Suurs Luc C J M; Visser Richard G F
Reduction of starch granule size by expression of an engineered tandem starch-binding domain in potato plants.
Plant biotechnology journal 2004;2(3):251-60.
2004: Pires Virgínia M R; Henshaw Joanna L; Prates José A M; Bolam David N; Ferreira Luís M A; Fontes Carlos M G A; Henrissat Bernard; Planas Antoni; Gilbert Harry J; Czjzek Mirjam
The crystal structure of the family 6 carbohydrate binding module from Cellvibrio mixtus endoglucanase 5a in complex with oligosaccharides reveals two distinct binding sites with different ligand specificities.
The Journal of biological chemistry 2004;279(20):21560-8.
2004: Bolam David N; Xie Hefang; Pell Gavin; Hogg Deborah; Galbraith Greta; Henrissat Bernard; Gilbert Harry J
X4 modules represent a new family of carbohydrate-binding modules that display novel properties.
The Journal of biological chemistry 2004;279(22):22953-63.
2004: Henshaw Joanna L; Bolam David N; Pires Virgínia M R; Czjzek Mirjam; Henrissat Bernard; Ferreira Luis M A; Fontes Carlos M G A; Gilbert Harry J
The family 6 carbohydrate binding module CmCBM6-2 contains two ligand-binding sites with distinct specificities.
The Journal of biological chemistry 2004;279(20):21552-9.
2004: Flint James; Nurizzo Didier; Harding Stephen E; Longman Emma; Davies Gideon J; Gilbert Harry J; Bolam David N
Ligand-mediated dimerization of a carbohydrate-binding molecule reveals a novel mechanism for protein-carbohydrate recognition.
Journal of molecular biology 2004;337(2):417-26.
2004: McCartney Lesley; Gilbert Harry J; Bolam David N; Boraston Alisdair B; Knox J Paul
Glycoside hydrolase carbohydrate-binding modules as molecular probes for the analysis of plant cell wall polymers.
Analytical biochemistry 2004;326(1):49-54.
2004: Pell Gavin; Szabo Lóránd; Charnock Simon J; Xie Hefang; Gloster Tracey M; Davies Gideon J; Gilbert Harry J
Structural and biochemical analysis of Cellvibrio japonicus xylanase 10C: how variation in substrate-binding cleft influences the catalytic profile of family GH-10 xylanases.
The Journal of biological chemistry 2004;279(12):11777-88.
2004: Pell Gavin; Taylor Edward J; Gloster Tracey M; Turkenburg Johan P; Fontes Carlos M G A; Ferreira Luis M A; Nagy Tibor; Clark Samantha J; Davies Gideon J; Gilbert Harry J
The mechanisms by which family 10 glycoside hydrolases bind decorated substrates.
The Journal of biological chemistry 2004;279(10):9597-605.
2004: Adams Elizabeth L; Kroon Paul A; Williamson Gary; Gilbert Harry J; Morris Victor J
Inactivated enzymes as probes of the structure of arabinoxylans as observed by atomic force microscopy.
Carbohydrate research 2004;339(3):579-90.
2004: Netherwood Trudy; Martín-Orúe Susana M; O'Donnell Anthony G; Gockling Sally; Graham Julia; Mathers John C; Gilbert Harry J
Assessing the survival of transgenic plant DNA in the human gastrointestinal tract.
Nature biotechnology 2004;22(2):204-9.
2003: Carvalho Ana L; Dias Fernando M V; Prates José A M; Nagy Tibor; Gilbert Harry J; Davies Gideon J; Ferreira Luís M A; Romão Maria J; Fontes Carlos M G A
Cellulosome assembly revealed by the crystal structure of the cohesin-dockerin complex.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):13809-14.
2003: Pell Gavin; Williamson Michael P; Walters Christopher; Du Haomao; Gilbert Harry J; Bolam David N
Importance of hydrophobic and polar residues in ligand binding in the family 15 carbohydrate-binding module from Cellvibrio japonicus Xyn10C.
Biochemistry 2003;42(31):9316-23.
2003: Harhangi Harry R; Freelove Alexander C J; Ubhayasekera Wimal; van Dinther Maarten; Steenbakkers Peter J M; Akhmanova Anna; van der Drift Chris; Jetten Mike S M; Mowbray Sherry L; Gilbert Harry J; Op den Camp Huub J M
Cel6A, a major exoglucanase from the cellulosome of the anaerobic fungi Piromyces sp. E2 and Piromyces equi.
Biochimica et biophysica acta 2003;1628(1):30-9.
2003: Vincent Florence; Charnock Simon J; Verschueren Koen H G; Turkenburg Johan P; Scott David J; Offen Wendy A; Roberts Shirley; Pell Gavin; Gilbert Harry J; Davies Gideon J; Brannigan James A
Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9A resolution.
Journal of molecular biology 2003;330(3):593-606.
2003: Jahn Michael; Stoll Dominik; Warren R Antony J; Szabó Lóránd; Singh Pritpal; Gilbert Harry J; Ducros Valérie M A; Davies Gideon J; Withers Stephen G
Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides.
Chemical communications (Cambridge, England) 2003;(12):1327-9.
2003: Gilbert Harry J
How carbohydrate binding modules overcome ligand complexity.
Structure (London, England : 1993) 2003;11(6):609-10.
2003: Nagy Tibor; Nurizzo Didier; Davies Gideon J; Biely Peter; Lakey Jeremy H; Bolam David N; Gilbert Harry J
The alpha-glucuronidase, GlcA67A, of Cellvibrio japonicus utilizes the carboxylate and methyl groups of aldobiouronic acid as important substrate recognition determinants.
The Journal of biological chemistry 2003;278(22):20286-92.
2003: Hogg Deborah; Pell Gavin; Dupree Paul; Goubet Florence; Martín-Orúe Susana M; Armand Sylvie; Gilbert Harry J
The modular architecture of Cellvibrio japonicus mannanases in glycoside hydrolase families 5 and 26 points to differences in their role in mannan degradation.
The Biochemical journal 2003;371(Pt 3):1027-43.
2003: Varrot Annabelle; Macdonald James; Stick Robert V; Pell Gavin; Gilbert Harry J; Davies Gideon J
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases.
Chemical communications (Cambridge, England) 2003;(8):946-7.
2003: Gilad Rachel; Rabinovich Larisa; Yaron Sima; Bayer Edward A; Lamed Raphael; Gilbert Harry J; Shoham Yuval
CelI, a noncellulosomal family 9 enzyme from Clostridium thermocellum, is a processive endoglucanase that degrades crystalline cellulose.
Journal of bacteriology 2003;185(2):391-8.
2002: Steenbakkers P J M; Freelove A; Van Cranenbroek B; Sweegers B M C; Harhangi H R; Vogels G D; Hazlewood G P; Gilbert H J; Op den Camp H J M
The major component of the cellulosomes of anaerobic fungi from the genus Piromyces is a family 48 glycoside hydrolase.
DNA sequence : the journal of DNA sequencing and mapping 2002;13(6):313-20.
2002: Charnock Simon J; Bolam David N; Nurizzo Didier; Szabó Lóránd; McKie Vincent A; Gilbert Harry J; Davies Gideon J
Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14077-82.
2002: Nurizzo Didier; Turkenburg Johan P; Charnock Simon J; Roberts Shirley M; Dodson Eleanor J; McKie Vincent A; Taylor Edward J; Gilbert Harry J; Davies Gideon J
Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold.
Nature structural biology 2002;9(9):665-8.
2002: Nagy Tibor; Emami Kaveh; Fontes Carlos M G A; Ferreira Luis M A; Humphry David R; Gilbert Harry J
The membrane-bound alpha-glucuronidase from Pseudomonas cellulosa hydrolyzes 4-O-methyl-D-glucuronoxylooligosaccharides but not 4-O-methyl-D-glucuronoxylan.
Journal of bacteriology 2002;184(17):4925-9.
2002: Ducros Valérie M-A; Zechel David L; Murshudov Garib N; Gilbert Harry J; Szabó Lóránd; Stoll Dominik; Withers Stephen G; Davies Gideon J
Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state.
Angewandte Chemie (International ed. in English) 2002;41(15):2824-7.
2002: Emami Kaveh; Nagy Tibor; Fontes Carlos M G A; Ferreira Luis M A; Gilbert Harry J
Evidence for temporal regulation of the two Pseudomonas cellulosa xylanases belonging to glycoside hydrolase family 11.
Journal of bacteriology 2002;184(15):4124-33.
2002: Martín-Orúe Susana M; O'Donnell Anthony G; Ariño Joaquin; Netherwood Trudy; Gilbert Harry J; Mathers John C
Degradation of transgenic DNA from genetically modified soya and maize in human intestinal simulations.
The British journal of nutrition 2002;87(6):533-42.
2002: Abou-Hachem Maher; Karlsson Eva Nordberg; Simpson Peter J; Linse Sara; Sellers Peter; Williamson Michael P; Jamieson Stuart J; Gilbert Harry J; Bolam David N; Holst Olle
Calcium binding and thermostability of carbohydrate binding module CBM4-2 of Xyn10A from Rhodothermus marinus.
Biochemistry 2002;41(18):5720-9.
2002: Simpson Peter J; Jamieson Stuart J; Abou-Hachem Maher; Karlsson Eva Nordberg; Gilbert Harry J; Holst Olle; Williamson Michael P
The solution structure of the CBM4-2 carbohydrate binding module from a thermostable Rhodothermus marinus xylanase.
Biochemistry 2002;41(18):5712-9.
2002: Nurizzo Didier; Nagy Tibor; Gilbert Harry J; Davies Gideon J
The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A.
Structure (London, England : 1993) 2002;10(4):547-56.
2001: Czjzek M; Bolam D N; Mosbah A; Allouch J; Fontes C M; Ferreira L M; Bornet O; Zamboni V; Darbon H; Smith N L; Black G W; Henrissat B; Gilbert H J
The location of the ligand-binding site of carbohydrate-binding modules that have evolved from a common sequence is not conserved.
The Journal of biological chemistry 2001;276(51):48580-7.
2001: Szabo L; Jamal S; Xie H; Charnock S J; Bolam D N; Gilbert H J; Davies G J
Structure of a family 15 carbohydrate-binding module in complex with xylopentaose. Evidence that xylan binds in an approximate 3-fold helical conformation.
The Journal of biological chemistry 2001;276(52):49061-5.
2001: Freelove A C; Bolam D N; White P; Hazlewood G P; Gilbert H J
A novel carbohydrate-binding protein is a component of the plant cell wall-degrading complex of Piromyces equi.
The Journal of biological chemistry 2001;276(46):43010-7.
2001: Beylot M H; McKie V A; Voragen A G; Doeswijk-Voragen C H; Gilbert H J
The Pseudomonas cellulosa glycoside hydrolase family 51 arabinofuranosidase exhibits wide substrate specificity.
The Biochemical journal 2001;358(Pt 3):607-14.
2001: Beylot M H; Emami K; McKie V A; Gilbert H J; Pell G
Pseudomonas cellulosa expresses a single membrane-bound glycoside hydrolase family 51 arabinofuranosidase.
The Biochemical journal 2001;358(Pt 3):599-605.
2001: Raghothama S; Eberhardt R Y; Simpson P; Wigelsworth D; White P; Hazlewood G P; Nagy T; Gilbert H J; Williamson M P
Characterization of a cellulosome dockerin domain from the anaerobic fungus Piromyces equi.
Nature structural biology 2001;8(9):775-8.
2001: Xie H; Gilbert H J; Charnock S J; Davies G J; Williamson M P; Simpson P J; Raghothama S; Fontes C M; Dias F M; Ferreira L M; Bolam D N
Clostridium thermocellum Xyn10B carbohydrate-binding module 22-2: the role of conserved amino acids in ligand binding.
Biochemistry 2001;40(31):9167-76.
2001: Hogg D; Woo E J; Bolam D N; McKie V A; Gilbert H J; Pickersgill R W
Crystal structure of mannanase 26A from Pseudomonas cellulosa and analysis of residues involved in substrate binding.
The Journal of biological chemistry 2001;276(33):31186-92.
2001: Armand S; Andrews S R; Charnock S J; Gilbert H J
Influence of the aglycone region of the substrate binding cleft of Pseudomonas xylanase 10A on catalysis.
Biochemistry 2001;40(25):7404-9.
2001: Xie H; Bolam D N; Nagy T; Szabó L; Cooper A; Simpson P J; Lakey J H; Williamson M P; Gilbert H J
Role of hydrogen bonding in the interaction between a xylan binding module and xylan.
Biochemistry 2001;40(19):5700-7.
2001: McKie V A; Vincken J P; Voragen A G; van den Broek L A; Stimson E; Gilbert H J
A new family of rhamnogalacturonan lyases contains an enzyme that binds to cellulose.
The Biochemical journal 2001;355(Pt 1):167-77.
2001: Bolam D N; Xie H; White P; Simpson P J; Hancock S M; Williamson M P; Gilbert H J
Evidence for synergy between family 2b carbohydrate binding modules in Cellulomonas fimi xylanase 11A.
Biochemistry 2001;40(8):2468-77.
2000: Simpson P J; Xie H; Bolam D N; Gilbert H J; Williamson M P
The structural basis for the ligand specificity of family 2 carbohydrate-binding modules.
The Journal of biological chemistry 2000;275(52):41137-42.
2000: Halstead J R; Fransen M P; Eberhart R Y; Park A J; Gilbert H J; Hazlewood G P
alpha-Galactosidase A from Pseudomonas fluorescens subsp. cellulosa: cloning, high level expression and its role in galactomannan hydrolysis.
FEMS microbiology letters 2000;192(2):197-203.
2000: Eberhardt R Y; Gilbert H J; Hazlewood G P
Primary sequence and enzymic properties of two modular endoglucanases, Cel5A and Cel45A, from the anaerobic fungus Piromyces equi.
Microbiology (Reading, England) 2000;146 ( Pt 8)():1999-2008.
2000: Fontes C M; Gilbert H J; Hazlewood G P; Clarke J H; Prates J A; McKie V A; Nagy T; Fernandes T H; Ferreira L M
A novel Cellvibrio mixtus family 10 xylanase that is both intracellular and expressed under non-inducing conditions.
Microbiology (Reading, England) 2000;146 ( Pt 8)():1959-67.
2000: Andrews S R; Charnock S J; Lakey J H; Davies G J; Claeyssens M; Nerinckx W; Underwood M; Sinnott M L; Warren R A; Gilbert H J
Substrate specificity in glycoside hydrolase family 10. Tyrosine 87 and leucine 314 play a pivotal role in discriminating between glucose and xylose binding in the proximal active site of Pseudomonas cellulosa xylanase 10A.
The Journal of biological chemistry 2000;275(30):23027-33.
2000: Clarke J H; Davidson K; Rixon J E; Halstead J R; Fransen M P; Gilbert H J; Hazlewood G P
A comparison of enzyme-aided bleaching of softwood paper pulp using combinations of xylanase, mannanase and alpha-galactosidase.
Applied microbiology and biotechnology 2000;53(6):661-7.
2000: Charnock S J; Bolam D N; Turkenburg J P; Gilbert H J; Ferreira L M; Davies G J; Fontes C M
The X6 "thermostabilizing" domains of xylanases are carbohydrate-binding modules: structure and biochemistry of the Clostridium thermocellum X6b domain.
Biochemistry 2000;39(17):5013-21.
2000: Ponyi T; Szabó L; Nagy T; Orosz L; Simpson P J; Williamson M P; Gilbert H J
Trp22, Trp24, and Tyr8 play a pivotal role in the binding of the family 10 cellulose-binding module from Pseudomonas xylanase A to insoluble ligands.
Biochemistry 2000;39(5):985-91.
2000: Raghothama S; Simpson P J; Szabó L; Nagy T; Gilbert H J; Williamson M P
Solution structure of the CBM10 cellulose binding module from Pseudomonas xylanase A.
Biochemistry 2000;39(5):978-84.
2000: Abou Hachem M; Nordberg Karlsson E; Bartonek-Roxâ E; Raghothama S; Simpson P J; Gilbert H J; Williamson M P; Holst O
Carbohydrate-binding modules from a thermostable Rhodothermus marinus xylanase: cloning, expression and binding studies.
The Biochemical journal 2000;345 Pt 1():53-60.
1999: Halstead J R; Vercoe P E; Gilbert H J; Davidson K; Hazlewood G P
A family 26 mannanase produced by Clostridium thermocellum as a component of the cellulosome contains a domain which is conserved in mannanases from anaerobic fungi.
Microbiology (Reading, England) 1999;145 ( Pt 11)():3101-8.
1999: Netherwood T; Bowden R; Harrison P; O'Donnell A G; Parker D S; Gilbert H J
Gene transfer in the gastrointestinal tract.
Applied and environmental microbiology 1999;65(11):5139-41.
1999: Netherwood T; Gilbert H J; Parker D S; O'Donnell A G
Probiotics shown to change bacterial community structure in the avian gastrointestinal tract.
Applied and environmental microbiology 1999;65(11):5134-8.
1999: Fillingham I J; Kroon P A; Williamson G; Gilbert H J; Hazlewood G P
A modular cinnamoyl ester hydrolase from the anaerobic fungus Piromyces equi acts synergistically with xylanase and is part of a multiprotein cellulose-binding cellulase-hemicellulase complex.
The Biochemical journal 1999;343 Pt 1():215-24.
1999: Gill J; Rixon J E; Bolam D N; McQueen-Mason S; Simpson P J; Williamson M P; Hazlewood G P; Gilbert H J
The type II and X cellulose-binding domains of Pseudomonas xylanase A potentiate catalytic activity against complex substrates by a common mechanism.
The Biochemical journal 1999;342 ( Pt 2)():473-80.
1999: Fernandes A C; Fontes C M; Gilbert H J; Hazlewood G P; Fernandes T H; Ferreira L M
Homologous xylanases from Clostridium thermocellum: evidence for bi-functional activity, synergism between xylanase catalytic modules and the presence of xylan-binding domains in enzyme complexes.
The Biochemical journal 1999;342 ( Pt 1)():105-10.
1999: Simpson P J; Bolam D N; Cooper A; Ciruela A; Hazlewood G P; Gilbert H J; Williamson M P
A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity.
Structure (London, England : 1993) 1999;7(7):853-64.
1999: Fontes C M; Ali S; Gilbert H J; Hazlewood G P; Hirst B H; Hall J
Bacterial xylanase expression in mammalian cells and transgenic mice.
Journal of biotechnology 1999;72(1-2):95-101.
1999: Southall S M; Simpson P J; Gilbert H J; Williamson G; Williamson M P
The starch-binding domain from glucoamylase disrupts the structure of starch.
FEBS letters 1999;447(1):58-60.
1999: Scott M; Pickersgill R W; Hazlewood G P; Gilbert H J; Harris G W
Crystallization and preliminary X-ray analysis of arabinanase A from Pseudomonas fluorescens subspecies cellulosa.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 2):544-6.
1998: Charnock S J; Spurway T D; Xie H; Beylot M H; Virden R; Warren R A; Hazlewood G P; Gilbert H J
The topology of the substrate binding clefts of glycosyl hydrolase family 10 xylanases are not conserved.
The Journal of biological chemistry 1998;273(48):32187-99.
1998: Nagy T; Simpson P; Williamson M P; Hazlewood G P; Gilbert H J; Orosz L
All three surface tryptophans in Type IIa cellulose binding domains play a pivotal role in binding both soluble and insoluble ligands.
FEBS letters 1998;429(3):312-6.
1998: Fontes C M; Clarke J H; Hazlewood G P; Fernandes T H; Gilbert H J; Ferreira L M
Identification of tandemly repeated type VI cellulose-binding domains in an endoglucanase from the aerobic soil bacterium Cellvibrio mixtus.
Applied microbiology and biotechnology 1998;49(5):552-9.
1998: Hazlewood G P; Gilbert H J
Structure and function analysis of Pseudomonas plant cell wall hydrolases.
Biochemical Society transactions 1998;26(2):185-90.
1998: Bolam D N; Ciruela A; McQueen-Mason S; Simpson P; Williamson M P; Rixon J E; Boraston A; Hazlewood G P; Gilbert H J
Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity.
The Biochemical journal 1998;331 ( Pt 3)():775-81.
1998: Walker D; Thwaites D T; Simmons N L; Gilbert H J; Hirst B H
Substrate upregulation of the human small intestinal peptide transporter, hPepT1.
The Journal of physiology 1998;507 ( Pt 3)():697-706.
1998: Scott M; Pickersgill R W; Hazlewood G P; Bolam D; Gilbert H J; Harris G W
Crystallization and preliminary X-ray diffraction studies of a family 26 endo-beta-1,4 mannanase (ManA) from Pseudomonas fluorescens subspecies cellulosa.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 1):129-31.
1998: Ciruela A; Gilbert H J; Ali B R; Hazlewood G P
Synergistic interaction of the cellulosome integrating protein (CipA) from Clostridium thermocellum with a cellulosomal endoglucanase.
FEBS letters 1998;422(2):221-4.
1998: Hazlewood G P; Gilbert H J
Structure and function analysis of Pseudomonas plant cell wall hydrolases.
Progress in nucleic acid research and molecular biology 1998;61():211-41.
1997: Braithwaite K L; Barna T; Spurway T D; Charnock S J; Black G W; Hughes N; Lakey J H; Virden R; Hazlewood G P; Henrissat B; Gilbert H J
Evidence that galactanase A from Pseudomonas fluorescens subspecies cellulosa is a retaining family 53 glycosyl hydrolase in which E161 and E270 are the catalytic residues.
Biochemistry 1997;36(49):15489-500.
1997: Ali S; Fontes C M; Hazlewood G P; Hirst B H; Clark A J; Gilbert H J; Hall J
Co-integration and expression of bacterial and genomic transgenes in the pancreatic and intestinal tissues of transgenic mice.
Gene 1997;202(1-2):203-8.
1997: Fontes C M; Clarke J H; Hazlewood G P; Fernandes T H; Gilbert H J; Ferreira L M
Possible roles for a non-modular, thermostable and proteinase-resistant cellulase from the mesophilic aerobic soil bacterium Cellvibrio mixtus.
Applied microbiology and biotechnology 1997;48(4):473-9.
1997: Black G W; Rixon J E; Clarke J H; Hazlewood G P; Ferreira L M; Bolam D N; Gilbert H J
Cellulose binding domains and linker sequences potentiate the activity of hemicellulases against complex substrates.
Journal of biotechnology 1997;57(1-3):59-69.
1997: Clarke J H; Rixon J E; Ciruela A; Gilbert H J; Hazlewood G P
Family-10 and family-11 xylanases differ in their capacity to enhance the bleachability of hardwood and softwood paper pulps.
Applied microbiology and biotechnology 1997;48(2):177-83.
1997: Spurway T D; Morland C; Cooper A; Sumner I; Hazlewood G P; O'Donnell A G; Pickersgill R W; Gilbert H J
Calcium protects a mesophilic xylanase from proteinase inactivation and thermal unfolding.
The Journal of biological chemistry 1997;272(28):17523-30.
1997: McKie V A; Black G W; Millward-Sadler S J; Hazlewood G P; Laurie J I; Gilbert H J
Arabinanase A from Pseudomonas fluorescens subsp. cellulosa exhibits both an endo- and an exo- mode of action.
The Biochemical journal 1997;323 ( Pt 2)():547-55.
1997: Charnock S J; Lakey J H; Virden R; Hughes N; Sinnott M L; Hazlewood G P; Pickersgill R; Gilbert H J
Key residues in subsite F play a critical role in the activity of Pseudomonas fluorescens subspecies cellulosa xylanase A against xylooligosaccharides but not against highly polymeric substrates such as xylan.
The Journal of biological chemistry 1997;272(5):2942-51.
1997: Bartolomé B; Faulds C B; Kroon P A; Waldron K; Gilbert H J; Hazlewood G; Williamson G
An Aspergillus niger esterase (ferulic acid esterase III) and a recombinant Pseudomonas fluorescens subsp. cellulosa esterase (Xy1D) release a 5-5' ferulic dehydrodimer (diferulic acid) from barley and wheat cell walls.
Applied and environmental microbiology 1997;63(1):208-12.
1996: Rixon J E; Clarke J H; Hazlewood G P; Hoyland R W; McCarthy A J; Gilbert H J
Do the non-catalytic polysaccharide-binding domains and linker regions enhance the biobleaching properties of modular xylanases?
Applied microbiology and biotechnology 1996;46(5-6):514-20.
1996: Bolam D N; Hughes N; Virden R; Lakey J H; Hazlewood G P; Henrissat B; Braithwaite K L; Gilbert H J
Mannanase A from Pseudomonas fluorescens ssp. cellulosa is a retaining glycosyl hydrolase in which E212 and E320 are the putative catalytic residues.
Biochemistry 1996;35(50):16195-204.
1996: Black G W; Rixon J E; Clarke J H; Hazlewood G P; Theodorou M K; Morris P; Gilbert H J
Evidence that linker sequences and cellulose-binding domains enhance the activity of hemicellulases against complex substrates.
The Biochemical journal 1996;319 ( Pt 2)():515-20.
1996: Millward-Sadler S J; Hall J; Black G W; Hazlewood G P; Gilbert H J
Evidence that the Piromyces gene family encoding endo-1,4-mannanases arose through gene duplication.
FEMS microbiology letters 1996;141(2-3):183-8.
1996: Clarke J H; Davidson K; Gilbert H J; Fontes C M; Hazlewood G P
A modular xylanase from mesophilic Cellulomonas fimi contains the same cellulose-binding and thermostabilizing domains as xylanases from thermophilic bacteria.
FEMS microbiology letters 1996;139(1):27-35.
1996: Ali S; Hall J; Hazlewood G P; Hirst B H; Gilbert H J
A protein targeting signal that functions in polarized epithelial cells in vivo.
The Biochemical journal 1996;315 ( Pt 3)():857-62.
1995: Fanutti C; Ponyi T; Black G W; Hazlewood G P; Gilbert H J
The conserved noncatalytic 40-residue sequence in cellulases and hemicellulases from anaerobic fungi functions as a protein docking domain.
The Journal of biological chemistry 1995;270(49):29314-22.
1995: Millward-Sadler S J; Davidson K; Hazlewood G P; Black G W; Gilbert H J; Clarke J H
Novel cellulose-binding domains, NodB homologues and conserved modular architecture in xylanases from the aerobic soil bacteria Pseudomonas fluorescens subsp. cellulosa and Cellvibrio mixtus.
The Biochemical journal 1995;312 ( Pt 1)():39-48.
1995: Philip J S; Gilbert H J; Smithard R R
Growth, viscosity and beta-glucanase activity of intestinal fluid in broiler chickens fed on barley-based diets with or without exogenous beta-glucanase.
British poultry science 1995;36(4):599-603.
1995: Hall J; Black G W; Ferreira L M; Millward-Sadler S J; Ali B R; Hazlewood G P; Gilbert H J
The non-catalytic cellulose-binding domain of a novel cellulase from Pseudomonas fluorescens subsp. cellulosa is important for the efficient hydrolysis of Avicel.
The Biochemical journal 1995;309 ( Pt 3)():749-56.
1995: Fontes C M; Hall J; Hirst B H; Hazlewood G P; Gilbert H J
The resistance of cellulases and xylanases to proteolytic inactivation.
Applied microbiology and biotechnology 1995;43(1):52-7.
1995: Black G W; Hazlewood G P; Millward-Sadler S J; Laurie J I; Gilbert H J
A modular xylanase containing a novel non-catalytic xylan-specific binding domain.
The Biochemical journal 1995;307 ( Pt 1)():191-5.
1995: Fontes C M; Hazlewood G P; Morag E; Hall J; Hirst B H; Gilbert H J
Evidence for a general role for non-catalytic thermostabilizing domains in xylanases from thermophilic bacteria.
The Biochemical journal 1995;307 ( Pt 1)():151-8.
1995: Faulds C B; Ralet M C; Williamson G; Hazlewood G P; Gilbert H J
Specificity of an esterase (XYLD) from Pseudomonas fluorescens subsp. cellulosa.
Biochimica et biophysica acta 1995;1243(2):265-9.
1995: Braithwaite K L; Black G W; Hazlewood G P; Ali B R; Gilbert H J
A non-modular endo-beta-1,4-mannanase from Pseudomonas fluorescens subspecies cellulosa.
The Biochemical journal 1995;305 ( Pt 3)():1005-10.
1995: Ali B R; Zhou L; Graves F M; Freedman R B; Black G W; Gilbert H J; Hazelwood G P
Cellulases and hemicellulases of the anaerobic fungus Piromyces constitute a multiprotein cellulose-binding complex and are encoded by multigene families.
FEMS microbiology letters 1995;125(1):15-21.
1995: Soole K L; Jepson M A; Hazlewood G P; Gilbert H J; Hirst B H
Epithelial sorting of a glycosylphosphatidylinositol-anchored bacterial protein expressed in polarized renal MDCK and intestinal Caco-2 cells.
Journal of cell science 1995;108 ( Pt 1)():369-77.
1994: Harris G W; Jenkins J A; Connerton I; Cummings N; Lo Leggio L; Scott M; Hazlewood G P; Laurie J I; Gilbert H J; Pickersgill R W
Structure of the catalytic core of the family F xylanase from Pseudomonas fluorescens and identification of the xylopentaose-binding sites.
Structure (London, England : 1993) 1994;2(11):1107-16.
1994: Black G W; Hazlewood G P; Xue G P; Orpin C G; Gilbert H J
Xylanase B from Neocallimastix patriciarum contains a non-catalytic 455-residue linker sequence comprised of 57 repeats of an octapeptide.
The Biochemical journal 1994;299 ( Pt 2)():381-7.
1994: Sharp R; Hazlewood G P; Gilbert H J; O'Donnell A G
Unmodified and recombinant strains of Lactobacillus plantarum are rapidly lost from the rumen by protozoal predation.
The Journal of applied bacteriology 1994;76(2):110-7.
1994: Zhou L; Xue G P; Orpin C G; Black G W; Gilbert H J; Hazlewood G P
Intronless celB from the anaerobic fungus Neocallimastix patriciarum encodes a modular family A endoglucanase.
The Biochemical journal 1994;297 ( Pt 2)():359-64.
1994: Millward-Sadler S J; Poole D M; Henrissat B; Hazlewood G P; Clarke J H; Gilbert H J
Evidence for a general role for high-affinity non-catalytic cellulose binding domains in microbial plant cell wall hydrolases.
Molecular microbiology 1994;11(2):375-82.
1993: Morag E; Bayer E A; Hazlewood G P; Gilbert H J; Lamed R
Cellulase Ss (CelS) is synonymous with the major cellobiohydrolase (subunit S8) from the cellulosome of Clostridium thermocellum.
Applied biochemistry and biotechnology 1993;43(2):147-51.
1993: Ferreira L M; Wood T M; Williamson G; Faulds C; Hazlewood G P; Black G W; Gilbert H J
A modular esterase from Pseudomonas fluorescens subsp. cellulosa contains a non-catalytic cellulose-binding domain.
The Biochemical journal 1993;294 ( Pt 2)():349-55.
1993: Soole K L; Hirst B H; Hazlewood G P; Gilbert H J; Laurie J L; Hall J
Secretion of a prokaryotic cellulase in bacterial and mammalian cells.
Gene 1993;125(1):85-9.
1993: Hall J; Ali S; Surani M A; Hazlewood G P; Clark A J; Simons J P; Hirst B H; Gilbert H J
Manipulation of the repertoire of digestive enzymes secreted into the gastrointestinal tract of transgenic mice.
Bio/technology (Nature Publishing Company) 1993;11(3):376-9.
1993: Soole K L; Hazlewood G P; Gilbert H J; Hirst B H
A glycosyl-phosphatidylinositol anchor can target a bacterial enzyme to the apical surface of polarized epithelial cells.
Biochemical Society transactions 1993;21(1):42S.
1993: Hazlewood G P; Davidson K; Laurie J I; Huskisson N S; Gilbert H J
Gene sequence and properties of CelI, a family E endoglucanase from Clostridium thermocellum.
Journal of general microbiology 1993;139(2):307-16.
1993: Poole D M; Hazlewood G P; Huskisson N S; Virden R; Gilbert H J
The role of conserved tryptophan residues in the interaction of a bacterial cellulose binding domain with its ligand.
FEMS microbiology letters 1993;106(1):77-83.
1993: Pickersgill R W; Jenkins J A; Scott M; Connerton I; Hazlewood G P; Gilbert H J
Crystallization and preliminary X-ray analysis of the catalytic domain of xylanase a from Pseudomonas fluorescens subspecies cellulosa.
Journal of molecular biology 1993;229(1):246-8.
1993: Hazlewood G P; Gilbert H J
Xylan and cellulose utilization by the clostridia.
Biotechnology (Reading, Mass.) 1993;25():311-41.
1992: Poole D M; Morag E; Lamed R; Bayer E A; Hazlewood G P; Gilbert H J
Identification of the cellulose-binding domain of the cellulosome subunit S1 from Clostridium thermocellum YS.
FEMS microbiology letters 1992;78(2-3):181-6.
1992: Rixon J E; Ferreira L M; Durrant A J; Laurie J I; Hazlewood G P; Gilbert H J
Characterization of the gene celD and its encoded product 1,4-beta-D-glucan glucohydrolase D from Pseudomonas fluorescens subsp. cellulosa.
The Biochemical journal 1992;285 ( Pt 3)():947-55.
1992: Gilbert H J; Hazlewood G P; Laurie J I; Orpin C G; Xue G P
Homologous catalytic domains in a rumen fungal xylanase: evidence for gene duplication and prokaryotic origin.
Molecular microbiology 1992;6(15):2065-72.
1992: Soole K L; Hall J; Jepson M A; Hazlewood G P; Gilbert H J; Hirst B H
Constitutive secretion of a bacterial enzyme by polarized epithelial cells.
Journal of cell science 1992;102 ( Pt 3)():495-504.
1992: Hall J; Hirst B H; Hazlewood G P; Gilbert H J
The use of chimeric gene constructs to express a bacterial endoglucanase in mammalian cells.
Biochimica et biophysica acta 1992;1130(3):259-66.
1992: Hazlewood G P; Laurie J I; Ferreira L M; Gilbert H J
Pseudomonas fluorescens subsp. cellulosa: an alternative model for bacterial cellulase.
The Journal of applied bacteriology 1992;72(3):244-51.
1991: Ferreira L M; Hazlewood G P; Barker P J; Gilbert H J
The cellodextrinase from Pseudomonas fluorescens subsp. cellulosa consists of multiple functional domains.
The Biochemical journal 1991;279 ( Pt 3)():793-9.
1991: Poole D M; Durrant A J; Hazlewood G P; Gilbert H J
Characterization of hybrid proteins consisting of the catalytic domains of Clostridium and Ruminococcus endoglucanases, fused to Pseudomonas non-catalytic cellulose-binding domains.
The Biochemical journal 1991;279 ( Pt 3)():787-92.
1991: Clarke J H; Laurie J I; Gilbert H J; Hazlewood G P
Multiple xylanases of Cellulomonas fimi are encoded by distinct genes.
FEMS microbiology letters 1991;67(3):305-9.
1991: Gilbert H J; Hazlewood G P
Genetic modification of fibre digestion.
The Proceedings of the Nutrition Society 1991;50(2):173-86.
1991: Goodenough P W; Clark D C; Durrant A J; Gilbert H J; Hazlewood G P; Waksman G
Structural analysis by circular dichroism of some enzymes involved in plant cell wall degradation.
FEBS letters 1991;282(2):355-8.
1991: Durrant A J; Hall J; Hazlewood G P; Gilbert H J
The non-catalytic C-terminal region of endoglucanase E from Clostridium thermocellum contains a cellulose-binding domain.
The Biochemical journal 1991;273(Pt 2)():289-93.
1990: Kellett L E; Poole D M; Ferreira L M; Durrant A J; Hazlewood G P; Gilbert H J
Xylanase B and an arabinofuranosidase from Pseudomonas fluorescens subsp. cellulosa contain identical cellulose-binding domains and are encoded by adjacent genes.
The Biochemical journal 1990;272(2):369-76.
1990: Hall J; Hazlewood G P; Surani M A; Hirst B H; Gilbert H J
Eukaryotic and prokaryotic signal peptides direct secretion of a bacterial endoglucanase by mammalian cells.
The Journal of biological chemistry 1990;265(32):19996-9.
1990: Hazlewood G P; Davidson K; Laurie J I; Romaniec M P; Gilbert H J
Cloning and sequencing of the celA gene encoding endoglucanase A of Butyrivibrio fibrisolvens strain A46.
Journal of general microbiology 1990;136(10):2089-97.
1990: Poole D M; Hazlewood G P; Laurie J I; Barker P J; Gilbert H J
Nucleotide sequence of the Ruminococcus albus SY3 endoglucanase genes celA and celB.
Molecular & general genetics : MGG 1990;223(2):217-23.
1990: Hazlewood G P; Davidson K; Clarke J H; Durrant A J; Hall J; Gilbert H J
Endoglucanase E, produced at high level in Escherichia coli as a lacZ' fusion protein, is part of the Clostridium thermocellum cellulosome.
Enzyme and microbial technology 1990;12(9):656-62.
1990: Ferreira L M; Durrant A J; Hall J; Hazlewood G P; Gilbert H J
Spatial separation of protein domains is not necessary for catalytic activity or substrate binding in a xylanase.
The Biochemical journal 1990;269(1):261-4.
1990: Gilbert H J; Hall J; Hazlewood G P; Ferreira L M
The N-terminal region of an endoglucanase from Pseudomonas fluorescens subspecies cellulosa constitutes a cellulose-binding domain that is distinct from the catalytic centre.
Molecular microbiology 1990;4(5):759-67.
1989: Bates E E; Gilbert H J
Characterization of a cryptic plasmid from Lactobacillus plantarum.
Gene 1989;85(1):253-8.
1989: Hall J; Hazlewood G P; Huskisson N S; Durrant A J; Gilbert H J
Conserved serine-rich sequences in xylanase and cellulase from Pseudomonas fluorescens subspecies cellulosa: internal signal sequence and unusual protein processing.
Molecular microbiology 1989;3(9):1211-9.
1989: Bates E E; Gilbert H J; Hazlewood G P; Huckle J; Laurie J I; Mann S P
Expression of a Clostridium thermocellum endoglucanase gene in Lactobacillus plantarum.
Applied and environmental microbiology 1989;55(8):2095-7.
1989: Minton N P; Whitehead P J; Atkinson T; Gilbert H J
Nucleotide sequence of an Erwinia chrysanthemi gene encoding shikimate kinase.
Nucleic acids research 1989;17(4):1769.
1988: Gilbert H J; Sullivan D A; Jenkins G; Kellett L E; Minton N P; Hall J
Molecular cloning of multiple xylanase genes from Pseudomonas fluorescens subsp. cellulosa.
Journal of general microbiology 1988;134(12):3239-47.
1988: Hall J; Hazlewood G P; Barker P J; Gilbert H J
Conserved reiterated domains in Clostridium thermocellum endoglucanases are not essential for catalytic activity.
Gene 1988;69(1):29-38.
1988: Hall J; Gilbert H J
The nucleotide sequence of a carboxymethylcellulase gene from Pseudomonas fluorescens subsp. cellulosa.
Molecular & general genetics : MGG 1988;213(1):112-7.
1987: Gilbert H J; Jenkins G; Sullivan D A; Hall J
Evidence for multiple carboxymethylcellulase genes in Pseudomonas fluorescens subsp. cellulosa.
Molecular & general genetics : MGG 1987;210(3):551-6.
1987: Anson J G; Gilbert H J; Oram J D; Minton N P
Complete nucleotide sequence of the Rhodosporidium toruloides gene coding for phenylalanine ammonia-lyase.
Gene 1987;58(2-3):189-99.
1986: Gilbert H J; Blazek R; Bullman H M; Minton N P
Cloning and expression of the Erwinia chrysanthemi asparaginase gene in Escherichia coli and Erwinia carotovora.
Journal of general microbiology 1986;132(1):151-60.
1986: Minton N P; Bullman H M; Scawen M D; Atkinson T; Gilbert H J
Nucleotide sequence of the Erwinia chrysanthemi NCPPB 1066 L-asparaginase gene.
Gene 1986;46(1):25-35.
1985: Gilbert H J; Tully M
Protection of phenylalanine ammonia-lyase from proteolytic attack.
Biochemical and biophysical research communications 1985;131(2):557-63.
1985: Gilbert H J; Clarke I N; Gibson R K; Stephenson J R; Tully M
Molecular cloning of the phenylalanine ammonia lyase gene from Rhodosporidium toruloides in Escherichia coli K-12.
Journal of bacteriology 1985;161(1):314-20.
1985: Tully M; Gilbert H J
Transformation of Rhodosporidium toruloides.
Gene 1985;36(3):235-40.
1983: Gilbert H J; Stephenson J R; Tully M
Control of synthesis of functional mRNA coding for phenylalanine ammonia-lyase from Rhodosporidium toruloides.
Journal of bacteriology 1983;153(3):1147-54.
1982: Gilbert H J; Tully M
Synthesis and degradation of phenylalanine ammonia-lyase of Rhodosporidium toruloides.
Journal of bacteriology 1982;150(2):498-505.
1981: Gilbert H J; Jack G W
The effect of proteinases on phenylalanine ammonia-lyase from the yeast Rhodotorula glutinis.
The Biochemical journal 1981;199(3):715-23.
1980: Gilbert H J; Drabble W T
Active-site modification of native and mutant forms of inosine 5'-monophosphate dehydrogenase from Escherichia coli K12.
The Biochemical journal 1980;191(2):533-41.
1980: Gilbert H J; Drabble W T
Complementation in vitro between guaB mutants of Escherichia coli K12.
Journal of general microbiology 1980;117(1):33-45.
1979: Gilbert H J; Lowe C R; Drabble W T
Inosine 5'-monophosphate dehydrogenase of Escherichia coli. Purification by affinity chromatography, subunit structure and inhibition by guanosine 5'-monophosphate.
The Biochemical journal 1979;183(3):481-94.

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