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RB Gilbertsen

Research Profile

Chemicals & Drugs

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Rats

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Publications

TOP 3
Yuntao Song; David T Connor; AD Sercel; Roderick J Sorenson; R Doubleday; Paul C Unangst; Bruce D Roth; V G Beylin; RB Gilbertsen; K Chan; DJ Schrier; A Guglietta; Dirk A Bornemeier; Richard D Dyer
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Yuntao Song; David T Connor; R Doubleday; Roderick J Sorenson; AD Sercel; Paul C Unangst; Bruce D Roth; RB Gilbertsen; K Chan; DJ Schrier; A Guglietta; Dirk A Bornemeier; Richard D Dyer
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Charles Lesch; E R Kraus; B Sanchez; RB Gilbertsen; A Guglietta
Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis.

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All Publications

1999: Yuntao Song; David T Connor; AD Sercel; Roderick J Sorenson; R Doubleday; Paul C Unangst; Bruce D Roth; V G Beylin; RB Gilbertsen; K Chan; DJ Schrier; A Guglietta; Dirk A Bornemeier; Richard D Dyer
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Journal of medicinal chemistry 1999;42(7):1161-9.
1999: Yuntao Song; David T Connor; R Doubleday; Roderick J Sorenson; AD Sercel; Paul C Unangst; Bruce D Roth; RB Gilbertsen; K Chan; DJ Schrier; A Guglietta; Dirk A Bornemeier; Richard D Dyer
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Journal of medicinal chemistry 1999;42(7):1151-60.
1999: Charles Lesch; E R Kraus; B Sanchez; RB Gilbertsen; A Guglietta
Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis.
Methods and findings in experimental and clinical pharmacology 1999;21(2):99-104.
1998: R Posmantur; Kevin Wang; RB Gilbertsen
Caspase-3-like activity is necessary for IL-2 release in activated Jurkat T-cells.
Experimental cell research 1998;244(1):302-9.
1998: Charles Lesch; RB Gilbertsen; Yuntao Song; Richard D Dyer; DJ Schrier; E R Kraus; B Sanchez; A Guglietta
Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.
The Journal of pharmacology and experimental therapeutics 1998;287(1):301-6.
1997: R Posmantur; Kevin Wang; Rathna Nath; RB Gilbertsen
A purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3-like protease activity in MOLT-4 T cells.
Immunopharmacology 1997;37(2-3):231-44.
1997: RB Gilbertsen; R Posmantur; Rathna Nath; Kevin Wang
Apoptotic death induced in MOLT-4 T-lymphoblasts by purine nucleoside phosphorylase inhibition.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46 Suppl 2():S151-2.
1997: Yuntao Song; David T Connor; Roderick J Sorenson; R Doubleday; AD Sercel; Paul C Unangst; RB Gilbertsen; K Chan; Dirk A Bornemeier; Richard D Dyer
2,6-di-tert-butylphenols: a new class of potent and selective PGHS-2 inhibitor.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46 Suppl 2():S141-2.
1997: R Posmantur; Kim M McGinnis; R Nadimpalli; RB Gilbertsen; Kevin Wang
Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells.
Journal of neurochemistry 1997;68(6):2328-37.
1994: RB Gilbertsen; M K Dong
Blockade of nucleoside degradation in monkey whole blood in vitro by CI-1000, a purine nucleoside phosphorylase (PNP) inhibitor.
Advances in experimental medicine and biology 1994;370():167-71.
1994: H Hallak; A Hayes; M Dong; RB Gilbertsen; R Guttendorf
Pharmacokinetics/pharmacodynamics of CI-1000, a purine nucleoside phosphorylase (PNP) inhibitor, in rats and monkeys.
Advances in experimental medicine and biology 1994;370():161-5.
1993: RB Gilbertsen; M K Dong; U Josyula; J C Sircar; D J Wilburn; M C Conroy
Activities of two 9-deazaguanine analogue inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955, in vitro and in vivo.
Annals of the New York Academy of Sciences 1993;685():248-51.
1993: M K Dong; RB Gilbertsen
PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. II. Effects on nucleoside catabolism in human and rat blood in vitro.
Agents and actions 1993;39 Spec No():C99-101.
1993: D J Wilburn; M K Dong; RB Gilbertsen
PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR).
Agents and actions 1993;39 Spec No():C96-8.
1992: RB Gilbertsen; U Josyula; J C Sircar; M K Dong; W S Wu; D J Wilburn; M C Conroy
Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955.
Biochemical pharmacology 1992;44(5):996-9.
1992: J C Sircar; C R Kostlan; RB Gilbertsen; M K Bennett; M K Dong; W J Cetenko
Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-one.
Journal of medicinal chemistry 1992;35(9):1605-9.
1992: P W Woo; C R Kostlan; J C Sircar; M K Dong; RB Gilbertsen
Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.
Journal of medicinal chemistry 1992;35(8):1451-7.
1992: M K Dong; M E Scott; Denis J Schrier; M J Suto; J C Sircar; A Black; T Chang; RB Gilbertsen
The biochemistry and pharmacology of PD 116124 (8-amino-2'-nordeoxyguanosine), an inhibitor of purine nucleoside phosphorylase (PNP).
The Journal of pharmacology and experimental therapeutics 1992;260(1):319-26.
1991: M K Dong; D J Wilburn; M C Conroy; RB Gilbertsen
Inhibition of interleukin-2 production and lymphocyte responsiveness by the cell activation inhibitor, CI-959.
Agents and actions 1991;34(1-2):53-5.
1991: RB Gilbertsen; M K Dong; L M Kossarek; J C Sircar; C R Kostlan; M C Conroy
Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972.
Biochemical and biophysical research communications 1991;178(3):1351-8.
1991: J C Sircar; C R Kostlan; RB Gilbertsen; M K Dong; W A Cetenko
Pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase (PNP) inhibitors as potential T-cell selective immunosuppressive agents.
Advances in experimental medicine and biology 1991;309A():45-8.
1991: RB Gilbertsen; M K Dong; D J Wilburn; L M Kossarek; J C Sircar; C R Kostlan; M C Conroy
Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor.
Advances in experimental medicine and biology 1991;309A():41-4.
1990: Denis J Schrier; M E Lesch; C D Wright; RB Gilbertsen
The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1874-9.
1989: RB Gilbertsen; K M Cullinen; D J Wilburn; M K Dong; M C Conroy
In vitro effects of the antiallergy compound, CI-949, on interleukin-1 and 2 release, and on mitogen and alloantigen responsiveness.
Agents and actions 1989;27(3-4):303-5.
1987: RB Gilbertsen; M E Scott; M K Dong; L M Kossarek; M K Bennett; Denis J Schrier; J C Sircar
Preliminary report on 8-amino-9-(2-thienylmethyl)guanine (PD 119,229), a novel and potent purine nucleoside phosphorylase inhibitor.
Agents and actions 1987;21(3-4):272-4.
1987: Denis J Schrier; S Moniot; M I Gluckman; RB Gilbertsen
The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice.
The Journal of pharmacy and pharmacology 1987;39(1):57-9.
1986: J C Sircar; M J Suto; M E Scott; M K Dong; RB Gilbertsen
Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine.
Journal of medicinal chemistry 1986;29(9):1804-6.
1986: RB Gilbertsen; M K Dong
Dipyridamole and 8-aminoguanosine inhibition of nucleoside metabolism in rat blood in vitro.
Advances in experimental medicine and biology 1986;195 Pt A():575-82.
1984: Denis J Schrier; RB Gilbertsen; M Lesch; Joseph C Fantone III
The role of neutrophils in type II collagen-induced arthritis in rats.
The American journal of pathology 1984;117(1):26-9.
1984: A W Probert; Denis J Schrier; RB Gilbertsen
Effects of antiarthritic compounds on type II collagen-induced arthritis in rats.
Archives internationales de pharmacodynamie et de thérapie 1984;269(1):167-76.