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Wayne Giles

Research Profile

Physiology

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Myocardial Contraction

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TOP 3
Robert A Rose; Mary M Maleckar; Darrell D Belke; Wayne R Giles
Ca(2+) entry through TRP-C channels regulates fibroblast biology in chronic atrial fibrillation.
Umberto Banderali; Kimberley A Hoeksema; Aarthi Jayanthan; Aru Narendran; Wayne R Giles
Ion channels in pediatric CNS Atypical Teratoid/Rhabdoid Tumor (AT/RT) cells: potential targets for novel therapeutic agents.
Yoichi Ajiro; Wayne R Giles; Noriko Saegusa; Diana M Stafforini; Kenneth W Spitzer
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.

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All Publications

2012: Robert A Rose; Mary M Maleckar; Darrell D Belke; Wayne R Giles
Ca(2+) entry through TRP-C channels regulates fibroblast biology in chronic atrial fibrillation.
Circulation 2012;126(17):2039-41.
2012: Umberto Banderali; Kimberley A Hoeksema; Aarthi Jayanthan; Aru Narendran; Wayne R Giles
Ion channels in pediatric CNS Atypical Teratoid/Rhabdoid Tumor (AT/RT) cells: potential targets for novel therapeutic agents.
Journal of neuro-oncology 2012;107(1):111-9.
2011: Yoichi Ajiro; Wayne R Giles; Noriko Saegusa; Diana M Stafforini; Kenneth W Spitzer
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2011;301(6):H2395-401.
2011: Robert B Clark; Darrell D Belke; Colleen Kondo; Wayne R Giles
Two-pore domain K⁺ channels regulate membrane potential of isolated human articular chondrocytes.
The Journal of physiology 2011;589(Pt 21):5071-89.
2011: James R Wilson; Umberto Banderali; Robert B Clark; Wayne R Giles
Measurement of the membrane potential in small cells using patch clamp methods.
Channels (Austin, Tex.) 2011;5(6):530-7.
2011: Umberto Banderali; Martin Fink; Wayne R Giles
Repolarization of the mammalian heart action potential is modulated by changes in osmotic strength.
Cardiovascular research 2011;91(3):376-7.
2010: Robert B Clark; Noriyuki Hatano; Colleen Kondo; Darrell D Belke; Barry S Brown; Sanjay Kumar; Bartholomew J Votta; Wayne R Giles
Voltage-gated K+ currents in mouse articular chondrocytes regulate membrane potential.
Channels (Austin, Tex.) 2010;4(3):179-91.
2010: Umberto Banderali; Peter F Juranka; Robert B Clark; Wayne R Giles; Catherine E Morris
Impaired stretch modulation in potentially lethal cardiac sodium channel mutants.
Channels (Austin, Tex.) 2010;4(1):12-21.
2009: M Figura; Lisa Chilton; Abdelhamid Liacini; M Maric Viskovic; V Phan; Derrice Knight; Timothy Millar; K Patel; Paul Kubes; Wayne R Giles; Lee Anne Tibbles
Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(4):687-96.
2008: Lee K Landeen; Dorothy A Dederko; Colleen S Kondo; Betty S Hu; Nakon Aroonsakool; Jason Haga; Wayne R Giles
Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H736-49.
2008: Robert A Rose; Wayne R Giles
Natriuretic peptide C receptor signalling in the heart and vasculature.
The Journal of physiology 2008;586(2):353-66.
2007: Lisa Chilton; Wayne R Giles; Godfrey L Smith
Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts.
The Journal of physiology 2007;583(Pt 1):225-36.
2007: Michael Hesse; Colleen S Kondo; Robert B Clark; Lin Su; Frances L Allen; Colleen T M Geary-Joo; Stanley Kunnathu; David L Severson; Anders Nygren; Wayne R Giles; James C Cross
Dilated cardiomyopathy is associated with reduced expression of the cardiac sodium channel Scn5a.
Cardiovascular research 2007;75(3):498-509.
2007: Betty S Hu; Lee K Landeen; Nakon Aroonsakool; Wayne R Giles
An analysis of the effects of stretch on IGF-I secretion from rat ventricular fibroblasts.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H677-83.
2007: Sarah N Flaim; Wayne R Giles; Andrew D McCulloch
Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: analysis of the I1768V SCN5A mutation.
Heart rhythm : the official journal of the Heart Rhythm Society 2007;4(6):768-78.
2007: Lee K Landeen; Nakon Aroonsakool; Jason Haga; Betty S Hu; Wayne R Giles
Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions.
American journal of physiology. Heart and circulatory physiology 2007;292(6):H2698-711.
2007: K Andrew Maccannell; Hojjat Bazzazi; Lisa Chilton; Yoshiyuki Shibukawa; Robert B Clark; Wayne R Giles
A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts.
Biophysical journal 2007;92(11):4121-32.
2007: Robert A Rose; N Hatano; S Ohya; Y Imaizumi; Wayne R Giles
C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling.
The Journal of physiology 2007;580(Pt 1):255-74.
2007: Christine Teutsch; Richard P Kondo; Dorothy A Dederko; Jacqueline Chrast; Kenneth R Chien; Wayne R Giles
Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection.
Cardiovascular research 2007;73(4):739-49.
2006: Sarah N Flaim; Wayne R Giles; Andrew D McCulloch
Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2006;291(6):H2617-29.
2006: Céline Fiset; Wayne R Giles
Transmural gradients of repolarization and excitation-contraction coupling in mouse ventricle.
Circulation research 2006;98(10):1237-9.
2006: Martin Fink; Wayne R Giles; Denis Noble
Contributions of inwardly rectifying K+ currents to repolarization assessed using mathematical models of human ventricular myocytes.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2006;364(1842):1207-22.
2006: Hojjat Bazzazi; Robert B Clark; Wayne R Giles
Mathematical simulations of the effects of altered AMP-kinase activity on I and the action potential in rat ventricle.
Journal of cardiovascular electrophysiology 2006;17 Suppl 1():S162-S168.
2006: Anders Nygren; István Baczkó; Wayne R Giles
Measurements of electrophysiological effects of components of acute ischemia in Langendorff-perfused rat hearts using voltage-sensitive dye mapping.
Journal of cardiovascular electrophysiology 2006;17 Suppl 1():S113-S123.
2006: Richard P Kondo; Dorothy A Dederko; Christine Teutsch; Jacqueline Chrast; Daniele Catalucci; Kenneth R Chien; Wayne R Giles
Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform.
The Journal of physiology 2006;571(Pt 1):131-46.
2006: Ilka Lorenzen-Schmidt; Geert W Schmid-Schönbein; Wayne R Giles; Andrew D McCulloch; Shu Chien; Jeffrey H Omens
Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear.
Cell biochemistry and biophysics 2006;46(2):113-22.
2005: Robert A Rose; Madhu B Anand-Srivastava; Wayne R Giles; Jaideep S Bains
C-type natriuretic peptide inhibits L-type Ca2+ current in rat magnocellular neurosecretory cells by activating the NPR-C receptor.
Journal of neurophysiology 2005;94(1):612-21.
2005: István Baczkó; Lynn Jones; Claire F McGuigan; Jocelyn E Manning Fox; Manoj Gandhi; Wayne R Giles; Alexander S Clanachan; Peter E Light
Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):980-2.
2005: Yoshiyuki Shibukawa; E Lisa Chilton; K Andrew Maccannell; Robert B Clark; Wayne R Giles
K+ currents activated by depolarization in cardiac fibroblasts.
Biophysical journal 2005;88(6):3924-35.
2005: Lisa Chilton; S Ohya; D Freed; E George; Vanja Drobic; Yoshiyuki Shibukawa; K Andrew Maccannell; Y Imaizumi; Robert B Clark; Ian M C Dixon; Wayne R Giles
K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts.
American journal of physiology. Heart and circulatory physiology 2005;288(6):H2931-9.
2004: Anders Nygren; Alan E Lomax; Wayne R Giles
Heterogeneity of action potential durations in isolated mouse left and right atria recorded using voltage-sensitive dye mapping.
American journal of physiology. Heart and circulatory physiology 2004;287(6):H2634-43.
2004: Judith Brouillette; Robert B Clark; Wayne R Giles; Céline Fiset
Functional properties of K+ currents in adult mouse ventricular myocytes.
The Journal of physiology 2004;559(Pt 3):777-98.
2004: Jim R Wilson; Neil A Duncan; Wayne R Giles; Robert B Clark
A voltage-dependent K+ current contributes to membrane potential of acutely isolated canine articular chondrocytes.
The Journal of physiology 2004;557(Pt 1):93-104.
2004: Robert A Rose; Alan E Lomax; Colleen S Kondo; Madhu B Anand-Srivastava; Wayne R Giles
Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: a role for the NPR-C receptor.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H1970-7.
2004: Robert B Clark; Matteo E Mangoni; Andreas Lueger; Brigitte Couette; Joël Nargeot; Wayne R Giles
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H1757-66.
2004: István Baczkó; Wayne R Giles; Peter E Light
Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential.
British journal of pharmacology 2004;141(6):1059-67.
2004: A Nygren; A E Lomax; Wayne R Giles
Optical mapping system for recording action potential durations in adult mouse left and right atrium.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2004;5():3576-7.
2003: Robert A Rose; Alan E Lomax; Wayne R Giles
Inhibition of L-type Ca2+ current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C-mediated effect.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2454-62.
2003: Alan E G Lomax; Keith Sharkey; Wayne R Giles
Neuropeptide y modulates L-type Ca2+ current during heart development.
Circulation research 2003;93(10):891-2.
2003: Alan E Lomax; Colleen S Kondo; Wayne R Giles
Comparison of time- and voltage-dependent K+ currents in myocytes from left and right atria of adult mice.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H1837-48.
2003: Jocelyn E Manning Fox; Jarkko Magga; Wayne R Giles; Peter E Light
Acyl coenzyme A esters differentially activate cardiac and beta-cell adenosine triphosphate-sensitive potassium channels in a side-chain length-specific manner.
Metabolism: clinical and experimental 2003;52(10):1313-9.
2003: Alan E Lomax; Robert A Rose; Wayne R Giles
Electrophysiological evidence for a gradient of G protein-gated K+ current in adult mouse atria.
British journal of pharmacology 2003;140(3):576-84.
2003: István Baczkó; Wayne R Giles; Peter E Light
Resting membrane potential regulates Na(+)-Ca2+ exchange-mediated Ca2+ overload during hypoxia-reoxygenation in rat ventricular myocytes.
The Journal of physiology 2003;550(Pt 3):889-98.
2003: Anders Nygren; Colleen S Kondo; Robert B Clark; Wayne R Giles
Voltage-sensitive dye mapping in Langendorff-perfused rat hearts.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H892-902.
2001: Robert B Clark; A Tremblay; P Melnyk; Bruce G Allen; Wayne R Giles; Céline Fiset
T-tubule localization of the inward-rectifier K(+) channel in mouse ventricular myocytes: a role in K(+) accumulation.
The Journal of physiology 2001;537(Pt 3):979-92.
2001: H C Kuo; Ching-Feng Cheng; Robert B Clark; J J Lin; J L Lin; Masahiko Hoshijima; V T Nguyêñ-Trân; Y Gu; Ikeda Yasuhiro; Pao-Hsien Chu; John Ross; Wayne R Giles; Kenneth R Chien
A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.
Cell 2001;107(6):801-13.
2001: Betty Y Poon; Christopher A Ward; Conan B Cooper; Wayne R Giles; A R Burns; Paul Kubes
alpha(4)-integrin mediates neutrophil-induced free radical injury to cardiac myocytes.
The Journal of cell biology 2001;152(5):857-66.
2001: Jonathan M Cordeiro; Kenneth W Spitzer; Wayne R Giles; P E Ershler; Mark Cannell; John H B Bridge
Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells.
The Journal of physiology 2001;531(Pt 2):301-14.
2000: Jian-Zhong Sheng; Clemens F M Prinsen; Robert B Clark; Wayne R Giles; Paul P M Schnetkamp
Na(+)-Ca(2+)-K(+) currents measured in insect cells transfected with the retinal cone or rod Na(+)-Ca(2+)-K(+) exchanger cDNA.
Biophysical journal 2000;79(4):1945-53.
2000: N Sato; H Tanaka; Y Habuchi; Wayne R Giles
Electrophysiological effects of ibutilide on the delayed rectifier K(+) current in rabbit sinoatrial and atrioventricular node cells.
European journal of pharmacology 2000;404(3):281-8.
2000: V T Nguyên-Trân; Steven W Kubalak; Susumu Minamisawa; Céline Fiset; K C Wollert; A B Brown; Pilar Ruiz-Lozano; S Barrere-Lemaire; Richard P Kondo; Lisa W Norman; Robert G Gourdie; MM Rahme; Gregory K Feld; Robert B Clark; Wayne R Giles; Kenneth R Chien
A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.
Cell 2000;102(5):671-82.
2000: Jiqing Guo; Wayne R Giles; Christopher A Ward
Effect of hydrogen peroxide on the membrane currents of sinoatrial node cells from rabbit heart.
American journal of physiology. Heart and circulatory physiology 2000;279(3):H992-9.
2000: Anders Nygren; Robert B Clark; Darrell D Belke; Colleen S Kondo; Wayne R Giles; FX Witkowski
Voltage-sensitive dye mapping of activation and conduction in adult mouse hearts.
Annals of biomedical engineering 2000;28(8):958-67.
2000: Anders Nygren; Wayne R Giles
Mathematical simulation of slowing of cardiac conduction velocity by elevated extracellular.
Annals of biomedical engineering 2000;28(8):951-7.
1999: Susumu Minamisawa; Masahiko Hoshijima; G Chu; Christopher A Ward; Konrad Frank; Y Gu; M E Martone; Yibin Wang; J Ross; E G Kranias; Wayne R Giles; K R Chien
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.
Cell 1999;99(3):313-22.
1999: Jiqing Guo; K L MacDonell; Wayne R Giles
Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells.
Pflügers Archiv : European journal of physiology 1999;438(5):642-8.
1999: Betty Y Poon; Christopher A Ward; Wayne R Giles; Paul Kubes
Emigrated neutrophils regulate ventricular contractility via alpha4 integrin.
Circulation research 1999;84(11):1245-51.
1999: Terje S Larsen; Darrell D Belke; Rozsa Sas; Wayne R Giles; D L Severson; G D Lopaschuk; John V Tyberg
The isolated working mouse heart: methodological considerations.
Pflügers Archiv : European journal of physiology 1999;437(6):979-85.
1998: K L MacDonell; David L Severson; Wayne R Giles
Depression of excitability by sphingosine 1-phosphate in rat ventricular myocytes.
The American journal of physiology 1998;275(6 Pt 2):H2291-9.
1998: N Sato; Y Habuchi; H Tanaka; Y Kawamura; K Kikuchi; Kenneth W Spitzer; Wayne R Giles
[Electrophysiological heterogeneity of rabbit atrioventricular node cells: possible relationship to fast and slow pathways].
Journal of cardiology 1998;31(6):373-80.
1998: Jonathan M Cordeiro; Kenneth W Spitzer; Wayne R Giles
Repolarizing K+ currents in rabbit heart Purkinje cells.
The Journal of physiology 1998;508 ( Pt 3)():811-23.
1998: FX Witkowski; L J Leon; PA Penkoske; Wayne R Giles; M L Spano; William L Ditto; A T Winfree
Spatiotemporal evolution of ventricular fibrillation.
Nature 1998;392(6671):78-82.
1998: A Nygren; Céline Fiset; L Firek; J W Clark; D S Lindblad; Robert B Clark; Wayne R Giles
Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization.
Circulation research 1998;82(1):63-81.
1997: L Firek; Wayne R Giles
Electrophysiological analyses of threshold conditions and rate-dependent failure of excitation in single myocytes from rabbit ventricle.
The Canadian journal of cardiology 1997;13(11):1113-24.
1997: FX Witkowski; Robert B Clark; Terje S Larsen; A Melnikov; Wayne R Giles
Voltage-sensitive dye recordings of electrophysiological activation in a Langendorff-perfused mouse heart.
The Canadian journal of cardiology 1997;13(11):1077-82.
1997: Céline Fiset; Robert B Clark; Terje S Larsen; Wayne R Giles
A rapidly activating sustained K+ current modulates repolarization and excitation-contraction coupling in adult mouse ventricle.
The Journal of physiology 1997;504 ( Pt 3)():557-63.
1997: Kenneth W Spitzer; N Sato; H Tanaka; L Firek; Massimiliano Zaniboni; Wayne R Giles
Electrotonic modulation of electrical activity in rabbit atrioventricular node myocytes.
The American journal of physiology 1997;273(2 Pt 2):H767-76.
1997: Christopher A Ward; Z Ma; Samuel S Lee; Wayne R Giles
Potassium currents in atrial and ventricular myocytes from a rat model of cirrhosis.
The American journal of physiology 1997;273(2 Pt 1):G537-44.
1997: PH Reinhardt; Christopher A Ward; Wayne R Giles; Paul Kubes
Emigrated rat neutrophils adhere to cardiac myocytes via alpha 4 integrin.
Circulation research 1997;81(2):196-201.
1997: Christopher A Ward; Wayne R Giles
Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.
The Journal of physiology 1997;500 ( Pt 3)():631-42.
1997: Yakhin Shimoni; Céline Fiset; Robert B Clark; J E Dixon; D McKinnon; Wayne R Giles
Thyroid hormone regulates postnatal expression of transient K+ channel isoforms in rat ventricle.
The Journal of physiology 1997;500 ( Pt 1)():65-73.
1997: Céline Fiset; Robert B Clark; Yakhin Shimoni; Wayne R Giles
Shal-type channels contribute to the Ca2+-independent transient outward K+ current in rat ventricle.
The Journal of physiology 1997;500 ( Pt 1)():51-64.
1996: Yakhin Shimoni; X Han; David L Severson; Wayne R Giles
Mediation by nitric oxide of the indirect effects of adenosine on calcium current in rabbit heart pacemaker cells.
British journal of pharmacology 1996;119(7):1463-9.
1996: D S Lindblad; C R Murphey; John Clark Jr.; Wayne R Giles
A model of the action potential and underlying membrane currents in a rabbit atrial cell.
The American journal of physiology 1996;271(4 Pt 2):H1666-96.
1996: Robert B Clark; R A Bouchard; Wayne R Giles
Action potential duration modulates calcium influx, Na(+)-Ca2+ exchange, and intracellular calcium release in rat ventricular myocytes.
Annals of the New York Academy of Sciences 1996;779():417-29.
1996: H Tanaka; R B Clark; Wayne R Giles
Positive chronotropic responses of rabbit sino-atrial node cells to flash photolysis of caged isoproterenol and cyclic AMP.
Proceedings. Biological sciences / The Royal Society 1996;263(1368):241-8.
1996: X Han; Peter E Light; Wayne R Giles; Robert J French
Identification and properties of an ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells.
The Journal of physiology 1996;490 ( Pt 2)():337-50.
1995: Katsuhiko Muraki; Yuji Imaizumi; Minoru Watanabe; Y Habuchi; Wayne R Giles
Delayed rectifier K+ current in rabbit atrial myocytes.
The American journal of physiology 1995;269(2 Pt 2):H524-32.
1995: L Firek; Wayne R Giles
Outward currents underlying repolarization in human atrial myocytes.
Cardiovascular research 1995;30(1):31-8.
1995: X Han; Yakhin Shimoni; Wayne R Giles
A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rate.
The Journal of general physiology 1995;106(1):45-65.
1995: R A Bouchard; Robert B Clark; Wayne R Giles
Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes. Action potential voltage-clamp measurements.
Circulation research 1995;76(5):790-801.
1995: Robert B Clark; J Sanchez-Chapula; E Salinas-Stefanon; Henry J Duff; Wayne R Giles
Quinidine-induced open channel block of K+ current in rat ventricle.
British journal of pharmacology 1995;115(2):335-43.
1994: Robert B Clark; E R Kinsberg; Wayne R Giles
Histochemical localization of nitric oxide synthase in the bullfrog intracardiac ganglion.
Neuroscience letters 1994;182(2):255-8.
1994: X Han; Yakhin Shimoni; Wayne R Giles
An obligatory role for nitric oxide in autonomic control of mammalian heart rate.
The Journal of physiology 1994;476(2):309-14.
1994: S S Demir; John Clark Jr.; C R Murphey; Wayne R Giles
A mathematical model of a rabbit sinoatrial node cell.
The American journal of physiology 1994;266(3 Pt 1):C832-52.
1994: X Han; Y Habuchi; Wayne R Giles
Relaxin increases heart rate by modulating calcium current in cardiac pacemaker cells.
Circulation research 1994;74(3):537-41.
1993: R A Bouchard; Robert B Clark; Wayne R Giles
Role of sodium-calcium exchange in activation of contraction in rat ventricle.
The Journal of physiology 1993;472():391-413.
1993: Robert B Clark; R A Bouchard; E Salinas-Stefanon; J Sanchez-Chapula; Wayne R Giles
Heterogeneity of action potential waveforms and potassium currents in rat ventricle.
Cardiovascular research 1993;27(10):1795-9.
1993: R A Bouchard; Robert B Clark; Wayne R Giles
Regulation of unloaded cell shortening by sarcolemmal sodium-calcium exchange in isolated rat ventricular myocytes.
The Journal of physiology 1993;469():583-99.
1993: J M Shumaker; John Clark Jr.; Wayne R Giles
Simulations of passive properties and action potential conduction in an idealized bullfrog atrial trabeculum.
Mathematical biosciences 1993;116(2):127-67.
1993: D Fedida; A P Braun; Wayne R Giles
Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms.
Physiological reviews 1993;73(2):469-87.
1993: Hamid Akbarali; Wayne R Giles
Ca2+ and Ca(2+)-activated Cl- currents in rabbit oesophageal smooth muscle.
The Journal of physiology 1993;460():117-33.
1992: A P Braun; D Fedida; Wayne R Giles
Activation of alpha 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes.
Pflügers Archiv : European journal of physiology 1992;421(5):431-9.
1992: Yakhin Shimoni; Robert B Clark; Wayne R Giles
Role of an inwardly rectifying potassium current in rabbit ventricular action potential.
The Journal of physiology 1992;448():709-27.
1992: Hamid Akbarali; D G Wyse; Wayne R Giles
Ionic currents in single cells from human cystic artery.
Circulation research 1992;70(3):536-45.
1991: J M Shumaker; John Clark Jr.; Wayne R Giles
A model of beta-adrenergic effects on calcium and potassium current in bullfrog atrial myocytes.
The American journal of physiology 1991;261(6 Pt 2):H1937-44.
1991: D Fedida; Wayne R Giles
Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle.
The Journal of physiology 1991;442():191-209.
1991: C R Murphey; John Clark Jr.; Wayne R Giles
A model of slow conduction in bullfrog atrial trabeculae.
Mathematical biosciences 1991;106(1):85-109.
1991: C R Murphey; John Clark Jr.; Wayne R Giles; Randall L Rasmusson; J A Halter; K Hicks; B Hoyt
Conduction in bullfrog atrial strands: simulations of the role of disc and extracellular resistance.
Mathematical biosciences 1991;106(1):39-84.
1991: D Fedida; A P Braun; Wayne R Giles
Alpha 1-adrenoceptors reduce background K+ current in rabbit ventricular myocytes.
The Journal of physiology 1991;441():673-84.
1991: J M Shumaker; John Clark Jr.; Wayne R Giles
A model of the phase-sensitivity of the pacemaking cell in the bullfrog heart.
Journal of theoretical biology 1991;151(2):193-230.
1991: K Ono; Wayne R Giles
Electrophysiological effects of calcitonin gene-related peptide in bull-frog and guinea-pig atrial myocytes.
The Journal of physiology 1991;436():195-217.
1991: Y Gotoh; Yuji Imaizumi; Minoru Watanabe; Erwin F Shibata; R B Clark; Wayne R Giles
Inhibition of transient outward K+ current by DHP Ca2+ antagonists and agonists in rabbit cardiac myocytes.
The American journal of physiology 1991;260(5 Pt 2):H1737-42.
1990: A P Braun; D Fedida; Robert B Clark; Wayne R Giles
Intracellular mechanisms for alpha 1-adrenergic regulation of the transient outward current in rabbit atrial myocytes.
The Journal of physiology 1990;431():689-712.
1990: K M Kavanagh; Henry J Duff; R Clark; K V Robinson; Wayne R Giles; D George Wyse
Monophasic versus biphasic cardiac stimulation: mechanism of decreased energy requirements.
Pacing and clinical electrophysiology : PACE 1990;13(10):1268-76.
1990: Randall L Rasmusson; John Clark Jr.; Wayne R Giles; K Robinson; R B Clark; Erwin F Shibata; Donald L Campbell
A mathematical model of electrophysiological activity in a bullfrog atrial cell.
The American journal of physiology 1990;259(2 Pt 2):H370-89.
1990: Robert B Clark; A Tse; Wayne R Giles
Electrophysiology of parasympathetic neurones isolated from the interatrial septum of bull-frog heart.
The Journal of physiology 1990;427():89-125.
1990: A Tse; Robert B Clark; Wayne R Giles
Muscarinic modulation of calcium current in neurones from the interatrial septum of bull-frog heart.
The Journal of physiology 1990;427():127-49.
1990: Randall L Rasmusson; John Clark Jr.; Wayne R Giles; Erwin F Shibata; Donald L Campbell
A mathematical model of a bullfrog cardiac pacemaker cell.
The American journal of physiology 1990;259(2 Pt 2):H352-69.
1990: D Fedida; Yakhin Shimoni; Wayne R Giles
Alpha-adrenergic modulation of the transient outward current in rabbit atrial myocytes.
The Journal of physiology 1990;423():257-77.
1990: J M Shumaker; John Clark Jr.; Wayne R Giles; G Szabo
A model of the muscarinic receptor-induced changes in K(+)-current and action potentials in the bullfrog atrial cell.
Biophysical journal 1990;57(3):567-76.
1989: D Fedida; Yakhin Shimoni; Wayne R Giles
A novel effect of norepinephrine on cardiac cells is mediated by alpha 1-adrenoceptors.
The American journal of physiology 1989;256(5 Pt 2):H1500-4.
1988: L Belardinelli; Wayne R Giles; A West
Ionic mechanisms of adenosine actions in pacemaker cells from rabbit heart.
The Journal of physiology 1988;405():615-33.
1988: Wayne R Giles; Y Imaizumi
Comparison of potassium currents in rabbit atrial and ventricular cells.
The Journal of physiology 1988;405():123-45.
1988: Robert B Clark; Wayne R Giles; Y Imaizumi
Properties of the transient outward current in rabbit atrial cells.
The Journal of physiology 1988;405():147-68.
1988: Donald L Campbell; Wayne R Giles; K Robinson; Erwin F Shibata
Studies of the sodium-calcium exchanger in bull-frog atrial myocytes.
The Journal of physiology 1988;403():317-40.
1988: Donald L Campbell; Wayne R Giles; J R Hume; Erwin F Shibata
Inactivation of calcium current in bull-frog atrial myocytes.
The Journal of physiology 1988;403():287-315.
1988: Donald L Campbell; Wayne R Giles; J R Hume; D Noble; Erwin F Shibata
Reversal potential of the calcium current in bull-frog atrial myocytes.
The Journal of physiology 1988;403():267-86.
1988: Donald L Campbell; Wayne R Giles; Erwin F Shibata
Ion transfer characteristics of the calcium current in bull-frog atrial myocytes.
The Journal of physiology 1988;403():239-66.
1986: L E Moore; R B Clark; Erwin F Shibata; Wayne R Giles
Comparison of steady-state electrophysiological properties of isolated cells from bullfrog atrium and sinus venosus.
The Journal of membrane biology 1986;89(2):131-8.
1985: Erwin F Shibata; Wayne R Giles
Ionic currents that generate the spontaneous diastolic depolarization in individual cardiac pacemaker cells.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(22):7796-800.
1985: Wayne R Giles; Erwin F Shibata
Voltage clamp of bull-frog cardiac pace-maker cells: a quantitative analysis of potassium currents.
The Journal of physiology 1985;368():265-92.