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Robert Gillies

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Nabila Brabez; Gerard Chassaing; Robert J Gillies; Ryan Lacy; Solange Lavielle; Ronald M Lynch; Kevin L Nguyen; Kara Saunders; Liping Xu; Victor J Hruby
Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment.
Gary V Martinez; Ali M Ahad; Ramesh Alleti; Domenico Coppola; Parastou Foroutan; Robert J Gillies; Mark C Lloyd; Valerie E Moberg; David L Morse; Suryakiran Navath; Venkataramanarao Rao; Kamini Sewda; Eugene A. Mash Jr.
Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.
Virendra Kumar; Kavindra Nath; Tawee Tanvetyanon; Claudia G Berman; Alberto Chiappori; Robert A Gatenby; Robert J Gillies; Jongphil Kim; Edward A Eikman
Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings.

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2013: Nabila Brabez; Gerard Chassaing; Robert J Gillies; Ryan Lacy; Solange Lavielle; Ronald M Lynch; Kevin L Nguyen; Kara Saunders; Liping Xu; Victor J Hruby
Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment.
Bioorganic & medicinal chemistry letters 2013;23(8):2422-5.
2013: Gary V Martinez; Ali M Ahad; Ramesh Alleti; Domenico Coppola; Parastou Foroutan; Robert J Gillies; Mark C Lloyd; Valerie E Moberg; David L Morse; Suryakiran Navath; Venkataramanarao Rao; Kamini Sewda; Eugene A. Mash Jr.
Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.
Bioorganic & medicinal chemistry letters 2013;23(7):2061-4.
2013: Virendra Kumar; Kavindra Nath; Tawee Tanvetyanon; Claudia G Berman; Alberto Chiappori; Robert A Gatenby; Robert J Gillies; Jongphil Kim; Edward A Eikman
Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings.
Clinical nuclear medicine 2013;38(3):175-82.
2013: Veronica Estrella; Robert A Gatenby; Kate Bailey; yoganand balagurunathan; Tingan Chen; Heather H Cornnell; Arig Ibrahim-Hashim; Joseph Johnson; Mark Lloyd; Jennifer M Rothberg; Bonnie F Sloane; Jonathan Wojtkowiak; Robert J Gillies
Acidity generated by the tumor microenvironment drives local invasion.
Cancer research 2013;73(5):1524-35.
2013: Jenny M Kreahling; Douglas Letson; Gary Martinez; Meera Raghavan; Tiffany Razabdouski; Damon Reed; Marilyn M Bui; Parastou Foroutan; Robert J Gillies; Soner Altiok
Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas.
PloS one 2013;8(3):e57523.
2013: Raul Martinez-Zaguilan; Linda S Tompkins; Robert J Gillies; Ronald M Lynch
Simultaneous analysis of intracellular pH and Ca²⁺ from cell populations.
Methods in molecular biology (Clifton, N.J.) 2013;937():253-71.
2012: Liping Xu; Michael R Caplan; Victor J Hruby; Jatinder S Josan; Ronald M Lynch; Eugene A. Mash Jr.; David L Morse; Josef Vagner; Robert J Gillies
Heterobivalent ligands target cell-surface receptor combinations in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(52):21295-300.
2012: Renu M Stephen; Amanda F Baker; Kathy Brown; Emmanuelle J Meuillet; Mark D Pagel; Robert J Gillies
Monitoring the development of xenograft triple-negative breast cancer models using diffusion-weighted magnetic resonance imaging.
Experimental biology and medicine (Maywood, N.J.) 2012;237(11):1273-80.
2012: Emmanuel Rios Velazquez; Hugo J W L Aerts; Dirk De Ruysscher; Andre Dekker; Robert J Gillies; Dmitry B Goldgof; Yuhua Gu; René Korn; Philippe Lambin
A semiautomatic CT-based ensemble segmentation of lung tumors: comparison with oncologists' delineations and with the surgical specimen.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2012;105(2):167-73.
2012: Virendra Kumar; Philippe Lambin; Matthew B Schabath; Dmitry B Goldgof; Yuhua Gu; Lawrence O Hall; Hugo J W L Aerts; yoganand balagurunathan; Satrajit Basu; Anders Berglund; Andre Dekker; Steven A Eschrich; David Fenstermacher; Kenneth Forster; Robert A Gatenby; Robert J Gillies
Radiomics: the process and the challenges.
Magnetic resonance imaging 2012;30(9):1234-48.
2012: Jonathan W Wojtkowiak; Robert J Gillies
Autophagy on Acid.
Autophagy 2012;8(11):1688-9.
2012: Julio Cárdenas-Rodríguez; Heather Cornnell; Jean-Philippe Galons; Robert J Gillies; Yuguo Li; Mark D Pagel; Amanda F Baker
Imaging biomarkers to monitor response to the hypoxia-activated prodrug TH-302 in the MiaPaCa2 flank xenograft model.
Magnetic resonance imaging 2012;30(7):1002-9.
2012: Jonathan W Wojtkowiak; Edward Haller; Virendra Kumar; Mark C Lloyd; Joshua B Proemsey; Jennifer M Rothberg; Karla J Schramm; Bonnie F Sloane; Robert J Gillies
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.
Cancer research 2012;72(16):3938-47.
2011: Venkataramanarao Rao; Narges K Tafreshi; Liping Xu; Ramesh Alleti; Robert J Gillies; David L Morse; Eugene A. Mash Jr.
A sucrose-derived scaffold for multimerization of bioactive peptides.
Bioorganic & medicinal chemistry 2011;19(21):6474-82.
2011: Jatinder S Josan; Ronald M Lynch; Eugene A. Mash Jr.; Rajesh Sankaranarayanan; Josef Vagner; Liping Xu; Heather L Handl; Victor J Hruby; Robert J Gillies
Cell-specific targeting by heterobivalent ligands.
Bioconjugate chemistry 2011;22(7):1270-8.
2011: Natasha K Martin; EA Gaffney; Robert A Gatenby; Robert J Gillies; Ian F Robey; Philip K Maini
A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system.
Mathematical biosciences 2011;230(1):1-11.
2010: Ramesh Alleti; Venkataramanarao Rao; Liping Xu; Robert J Gillies; Eugene A. Mash Jr.
A solanesol-derived scaffold for multimerization of bioactive peptides.
The Journal of organic chemistry 2010;75(17):5895-903.
2010: David L Morse; yoganand balagurunathan; Galen Hostetter; Maria Trissal; Narges K Tafreshi; Nancy Burke; Mark Lloyd; Steven Enkemann; Domenico Coppola; Victor J Hruby; Robert J Gillies; Haiyong Han
Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray.
Biochemical pharmacology 2010;80(5):748-54.
2010: David L Morse; Robert J Gillies
Molecular imaging and targeted therapies.
Biochemical pharmacology 2010;80(5):731-8.
2010: Xiaomeng Zhang; Yuxiang Lin; Robert J Gillies
Tumor pH and its measurement.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(8):1167-70.
2010: Yeon Sun Lee; Steve Fernandes; Vinod Kulkarani; Alexander V Mayorov; Peg Davis; Shou-wu Ma; Kathy Brown; Robert J Gillies; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.
Bioorganic & medicinal chemistry letters 2010;20(14):4080-4.
2010: Liping Xu; Josef Vagner; Ramesh Alleti; Venkataramanarao Rao; Bhumasamudram Jagadish; David L Morse; Victor J Hruby; Robert J Gillies; Eugene A. Mash Jr.
Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors.
Bioorganic & medicinal chemistry letters 2010;20(8):2489-92.
2010: Channa R De Silva; Josef Vagner; Ronald Lynch; Robert J Gillies; Victor J Hruby
Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions.
Analytical biochemistry 2010;398(1):15-23.
2009: Elena V Rosca; Robert J Gillies; Michael R Caplan
Glioblastoma targeting via integrins is concentration dependent.
Biotechnology and bioengineering 2009;104(2):408-17.
2009: Liping Xu; Josef Vagner; Jatinder Josan; Ronald M Lynch; David L Morse; Brenda Baggett; Haiyong Han; Eugene A. Mash Jr.; Victor J Hruby; Robert J Gillies
Enhanced targeting with heterobivalent ligands.
Molecular cancer therapeutics 2009;8(8):2356-65.
2009: Jatinder S Josan; David L Morse; Liping Xu; Maria Trissal; Brenda Baggett; Peg Davis; Josef Vagner; Robert J Gillies; Victor J Hruby
Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging.
Organic letters 2009;11(12):2479-82.
2009: Ian F Robey; Brenda K Baggett; Nathaniel D Kirkpatrick; Denise J Roe; Julie Dosescu; Bonnie F Sloane; Arig Ibrahim Hashim; David L Morse; Natarajan Raghunand; Robert A Gatenby; Robert J Gillies
Bicarbonate increases tumor pH and inhibits spontaneous metastases.
Cancer research 2009;69(6):2260-8.
2009: Jatinder S Josan; Rajesh Sankaranarayanan; Heather L Handl; Steve Fernandes; Liping Xu; Josef Vagner; Robert J Gillies; Victor J Hruby
Heterobivalent ligands crosslink multiple cell-surface receptors--a step towards personal medicine.
Advances in experimental medicine and biology 2009;611():413-4.
2009: David L Morse; Danielle Carroll; Sam Day; Heather Gray; Pooja Sadarangani; Shiva Murthi; Constantin Job; Brenda Baggett; Natarajan Raghunand; Robert J Gillies
Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway.
NMR in biomedicine 2009;22(1):114-27.
2008: Dominique Jennings; Natarajan Raghunand; Robert J Gillies
Imaging hemodynamics.
Cancer metastasis reviews 2008;27(4):589-613.
2008: Thomas A Shewmake; Francisco J Solis; Robert J Gillies; Michael R Caplan
Effects of linker length and flexibility on multivalent targeting.
Biomacromolecules 2008;9(11):3057-64.
2008: Silvia Lope-Piedrafita; Maria L Garcia-Martin; Jean-Philippe Galons; Robert J Gillies; Theodore P Trouard
Longitudinal diffusion tensor imaging in a rat brain glioma model.
NMR in biomedicine 2008;21(8):799-808.
2008: Ian F Robey; Renu M Stephen; Kathy S Brown; Brenda Baggett; Robert A Gatenby; Robert J Gillies
Regulation of the Warburg effect in early-passage breast cancer cells.
Neoplasia (New York, N.Y.) 2008;10(8):745-56.
2008: Theodore P Trouard; Kevin D Harkins; Joseph L Divijak; Robert J Gillies; Jean-Philippe Galons
Ischemia-induced changes of intracellular water diffusion in rat glioma cell cultures.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;60(2):258-64.
2008: Robert J Gillies; Ian F Robey; Robert A Gatenby
Causes and consequences of increased glucose metabolism of cancers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49 Suppl 2():24S-42S.
2008: Mark A Borden; Hua Zhang; Robert J Gillies; Paul A Dayton; Katherine W Ferrara
A stimulus-responsive contrast agent for ultrasound molecular imaging.
Biomaterials 2008;29(5):597-606.
2008: Josef Vagner; Liping Xu; Heather L Handl; Jatinder S Josan; David L Morse; Eugene A. Mash Jr.; Robert J Gillies; Victor J Hruby
Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors.
Angewandte Chemie (International ed. in English) 2008;47(9):1685-8.
2008: Robert A Gatenby; Robert J Gillies
A microenvironmental model of carcinogenesis.
Nature reviews. Cancer 2008;8(1):56-61.
2007: Ellen Ackerstaff; Dmitri Artemov; Robert J Gillies; Zaver M Bhujwalla
Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism.
Neoplasia (New York, N.Y.) 2007;9(12):1138-51.
2007: Elena V Rosca; Jill M Stukel; Robert J Gillies; Josef Vagner; Michael R Caplan
Specificity and mobility of biomacromolecular, multivalent constructs for cellular targeting.
Biomacromolecules 2007;8(12):3830-5.
2007: David L Morse; Jean-Philippe Galons; Claire M Payne; Dominique L Jennings; Sam Day; Guowei Xia; Robert J Gillies
MRI-measured water mobility increases in response to chemotherapy via multiple cell-death mechanisms.
NMR in biomedicine 2007;20(6):602-14.
2007: Robert A Gatenby; Kieran Smallbone; Philip K Maini; F Rose; J Averill; Raymond B Nagle; L Worrall; Robert J Gillies
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer.
British journal of cancer 2007;97(5):646-53.
2007: Mark A Borden; Charles F Caskey; Erika Little; Robert J Gillies; Katherine W Ferrara
DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles.
Langmuir : the ACS journal of surfaces and colloids 2007;23(18):9401-8.
2007: David L Morse; Natarajan Raghunand; Pooja Sadarangani; Shiva Murthi; Constantin Job; Sam Day; Christine Howison; Robert J Gillies
Response of choline metabolites to docetaxel therapy is quantified in vivo by localized (31)P MRS of human breast cancer xenografts and in vitro by high-resolution (31)P NMR spectroscopy of cell extracts.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;58(2):270-80.
2007: Heather L Handl; Rajesh Sankaranarayanan; Jatinder S Josan; Josef Vagner; Eugene A. Mash Jr.; Robert J Gillies; Victor J Hruby
Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R).
Bioconjugate chemistry 2007;18(4):1101-9.
2007: Bhumasamudram Jagadish; Rajesh Sankaranarayanan; Liping Xu; Reyniak Richards; Josef Vagner; Victor J Hruby; Robert J Gillies; Eugene A. Mash Jr.
Squalene-derived flexible linkers for bioactive peptides.
Bioorganic & medicinal chemistry letters 2007;17(12):3310-3.
2007: Robert J Gillies; Robert A Gatenby
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?
Journal of bioenergetics and biomembranes 2007;39(3):251-7.
2007: Robert J Gillies; Robert A Gatenby
Hypoxia and adaptive landscapes in the evolution of carcinogenesis.
Cancer metastasis reviews 2007;26(2):311-7.
2007: Renu M Stephen; Robert J Gillies
Promise and progress for functional and molecular imaging of response to targeted therapies.
Pharmaceutical research 2007;24(6):1172-85.
2007: Martina E Bowen; Yasunari Monguchi; Rajesh Sankaranarayanan; Josef Vagner; Lucinda J Begay; Liping Xu; Bhumasamudram Jagadish; Victor J Hruby; Robert J Gillies; Eugene A. Mash Jr.
Design, synthesis, and validation of a branched flexible linker for bioactive peptides.
The Journal of organic chemistry 2007;72(5):1675-80.
2007: Kieran Smallbone; Robert A Gatenby; Robert J Gillies; Philip K Maini; David J Gavaghan
Metabolic changes during carcinogenesis: potential impact on invasiveness.
Journal of theoretical biology 2007;244(4):703-13.
2007: Robert A Gatenby; Robert J Gillies
Glycolysis in cancer: a potential target for therapy.
The international journal of biochemistry & cell biology 2007;39(7-8):1358-66.
2006: Bonnie F Sloane; Robert J Gillies; Suresh Mohla; John A Sogn; Anne Menkens; Daniel C Sullivan
I2 imaging: cancer biology and the tumor microenvironment.
Cancer research 2006;66(23):11097-9.
2006: Josef Vagner; Heather L Handl; Yasunari Monguchi; Umasish Jana; Lucinda J Begay; Eugene A. Mash Jr.; Victor J Hruby; Robert J Gillies
Rigid linkers for bioactive peptides.
Bioconjugate chemistry 2006;17(6):1545-50.
2006: Natarajan Raghunand; Bhumasamudram Jagadish; Theodore P Trouard; Jean-Philippe Galons; Robert J Gillies; Eugene A. Mash Jr.
Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;55(6):1272-80.
2006: Robert A Gatenby; Edward T Gawlinski; Arthur F Gmitro; Brant Kaylor; Robert J Gillies
Acid-mediated tumor invasion: a multidisciplinary study.
Cancer research 2006;66(10):5216-23.
2006: Mark A Borden; Gary V Martinez; Josette Ricker; Nelly M Tsvetkova; Marjorie Longo; Robert J Gillies; Paul A Dayton; Katherine W Ferrara
Lateral phase separation in lipid-coated microbubbles.
Langmuir : the ACS journal of surfaces and colloids 2006;22(9):4291-7.
2006: Maria L Garcia-Martin; Gary V Martinez; Natarajan Raghunand; A Dean Sherry; Shanrong Zhang; Robert J Gillies
High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;55(2):309-15.
2006: Raul Martinez-Zaguilan; Linda S Tompkins; Robert J Gillies; Ronald M Lynch
Simultaneous analysis of intracellular pH and Ca2+ from cell populations.
Methods in molecular biology (Clifton, N.J.) 2006;312():269-87.
2005: Bénédicte F Jordan; Kvar Black; Ian F Robey; Matthew Runquist; Garth Powis; Robert J Gillies
Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo.
NMR in biomedicine 2005;18(7):430-9.
2005: David L Morse; Heather Gray; Claire M Payne; Robert J Gillies
Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells.
Molecular cancer therapeutics 2005;4(10):1495-504.
2005: Heather L Handl; Josef Vagner; Henry I Yamamura; Victor J Hruby; Robert J Gillies
Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor.
Analytical biochemistry 2005;343(2):299-307.
2005: Jean-Philippe Galons; Silvia Lope-Piedrafita; Joseph L Divijak; Curtis A. Corum; Robert J Gillies; Theodore P Trouard
Uncovering of intracellular water in cultured cells.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;54(1):79-86.
2005: David L Morse; Danielle Carroll; Lyndon Weberg; Mark C Borgstrom; James Ranger-Moore; Robert J Gillies
Determining suitable internal standards for mRNA quantification of increasing cancer progression in human breast cells by real-time reverse transcriptase polymerase chain reaction.
Analytical biochemistry 2005;342(1):69-77.
2005: Heather L Handl; Robert J Gillies
Lanthanide-based luminescent assays for ligand-receptor interactions.
Life sciences 2005;77(4):361-71.
2005: Bénédicte F Jordan; Matthew Runquist; Natarajan Raghunand; Amanda Baker; Ryan Williams; Lynn Kirkpatrick; Garth Powis; Robert J Gillies
Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.
Neoplasia (New York, N.Y.) 2005;7(5):475-85.
2005: Robert J Gillies; John M Hoffman; Kit S Lam; Anne Menkens; David R Piwnica-Worms; Daniel C Sullivan; Ralph Weissleder
Meeting report: high-throughput technologies for in vivo imaging agents.
Molecular imaging 2005;4(2):98-103.
2005: Ian F Robey; Anthony D Lien; Sarah J Welsh; Brenda Baggett; Robert J Gillies
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.
Neoplasia (New York, N.Y.) 2005;7(4):324-30.
2005: Bénédicte F Jordan; Matthew Runquist; Natarajan Raghunand; Robert J Gillies; Wendy R Tate; Garth Powis; Amanda F Baker
The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):529-36.
2005: Raul Martinez-Zaguilan; Linda S Tompkins; Robert J Gillies; Ronald M Lynch
Simultaneous analysis of intracellular pH and Ca²+ from cell populations.
Methods in molecular biology (Clifton, N.J.) 2005;312():269-87.
2005: Robert J Gillies; David L Morse
In vivo magnetic resonance spectroscopy in cancer.
Annual review of biomedical engineering 2005;7():287-326.
2004: Heather L Handl; Josef Vagner; Haiyong Han; Eugene A. Mash Jr.; Victor J Hruby; Robert J Gillies
Hitting multiple targets with multimeric ligands.
Expert opinion on therapeutic targets 2004;8(6):565-86.
2004: Rebecca J Theilmann; Rebecca Borders; Theodore P Trouard; Guowei Xia; Eric K Outwater; James Ranger-Moore; Robert J Gillies; Alison T Stopeck
Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy.
Neoplasia (New York, N.Y.) 2004;6(6):831-7.
2004: Robert A Gatenby; Robert J Gillies
Why do cancers have high aerobic glycolysis?
Nature reviews. Cancer 2004;4(11):891-9.
2004: Brenda Baggett; Rupali Roy; Shafinaz Momen; Sherif Morgan; Laurence Tisi; David Morse; Robert J Gillies
Thermostability of firefly luciferases affects efficiency of detection by in vivo bioluminescence.
Molecular imaging 2004;3(4):324-32.
2004: Robert J Gillies; Natarajan Raghunand; Maria L Garcia-Martin; Robert A Gatenby
pH imaging. A review of pH measurement methods and applications in cancers.
IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society 2004;23(5):57-64.
2004: Heather L Handl; Josef Vagner; Henry I Yamamura; Victor J Hruby; Robert J Gillies
Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions.
Analytical biochemistry 2004;330(2):242-50.
2004: Josef Vagner; Heather L Handl; Robert J Gillies; Victor J Hruby
Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH.
Bioorganic & medicinal chemistry letters 2004;14(1):211-5.
2004: Eric C Bascuñan-Castillo; Robert P Erickson; Christine Howison; Robert J Hunter; Randall H Heidenreich; Chad Hicks; Theodore P Trouard; Robert J Gillies
Tamoxifen and vitamin E treatments delay symptoms in the mouse model of Niemann-Pick C.
Journal of applied genetics 2004;45(4):461-7.
2003: Victoria M Lukasik; Robert J Gillies
Animal anaesthesia for in vivo magnetic resonance.
NMR in biomedicine 2003;16(8):459-67.
2003: Natarajan Raghunand; Brent P Mahoney; Robert J Gillies
Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents.
Biochemical pharmacology 2003;66(7):1219-29.
2003: Brent P Mahoney; Natarajan Raghunand; Brenda Baggett; Robert J Gillies
Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro.
Biochemical pharmacology 2003;66(7):1207-18.
2003: Paul A Schornack; Robert J Gillies
Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors.
Neoplasia (New York, N.Y.) 2003;5(2):135-45.
2003: Robert J Gillies
Noninvasive imaging of anticancer therapy.
Molecular cancer therapeutics 2003;2(3):333-4.
2003: Natarajan Raghunand; Christine Howison; A Dean Sherry; Shanrong Zhang; Robert J Gillies
Renal and systemic pH imaging by contrast-enhanced MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;49(2):249-57.
2003: Natarajan Raghunand; Robert A Gatenby; Robert J Gillies
Microenvironmental and cellular consequences of altered blood flow in tumours.
The British journal of radiology 2003;76 Spec No 1():S11-22.
2002: Robert J Gillies; Natarajan Raghunand; Gregory S Karczmar; Zaver M Bhujwalla
MRI of the tumor microenvironment.
Journal of magnetic resonance imaging : JMRI 2002;16(4):430-50.
2002: Natarajan Raghunand; Shanrong Zhang; A Dean Sherry; Robert J Gillies
In vivo magnetic resonance imaging of tissue pH using a novel pH-sensitive contrast agent, GdDOTA-4AmP.
Academic radiology 2002;9 Suppl 2():S481-3.
2002: Dominique Jennings; B Nicholas Hatton; Jingyu Guo; Jean-Philippe Galons; Theodore P Trouard; Natarajan Raghunand; James Marshall; Robert J Gillies
Early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion MRI.
Neoplasia (New York, N.Y.) 2002;4(3):255-62.
2002: Zaver M Bhujwalla; Dmitri Artemov; Paloma Ballesteros; S Cerdan; Robert J Gillies; Meiyappan Solaiyappan
Combined vascular and extracellular pH imaging of solid tumors.
NMR in biomedicine 2002;15(2):114-9.
2001: Natarajan Raghunand; Brent P Mahoney; R van Sluis; Brenda Baggett; Robert J Gillies
Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone.
Neoplasia (New York, N.Y.) 2001;3(3):227-35.
2001: Robert J Gillies
Causes and consequences of hypoxia and acidity in tumors--Novartis Foundation symposium.
Trends in molecular medicine 2001;7(2):47-9.
2001: Robert J Gillies; Ronald M Lynch
Frontiers in the measurement of cell and tissue pH.
Novartis Foundation symposium 2001;240():7-19; discussion 19-22, 152-3.
2001: Zaver M Bhujwalla; Dmitri Artemov; EO Aboagye; Ellen Ackerstaff; Robert J Gillies; Kshama Natarajan; Meiyappan Solaiyappan
The physiological environment in cancer vascularization, invasion and metastasis.
Novartis Foundation symposium 2001;240():23-38; discussion 38-45, 152-3.
2001: Natarajan Raghunand; Robert J Gillies
pH and chemotherapy.
Novartis Foundation symposium 2001;240():199-211; discussion 265-8.
2001: Robert J Gillies
The tumour microenvironment: causes and consequences of hypoxia and acidity. Introduction.
Novartis Foundation symposium 2001;240():1-6.
2000: Ulrich Pilatus; Ellen Ackerstaff; Dmitri Artemov; Noriko Mori; Robert J Gillies; Zaver M Bhujwalla
Imaging prostate cancer invasion with multi-nuclear magnetic resonance methods: the Metabolic Boyden Chamber.
Neoplasia (New York, N.Y.) 2000;2(3):273-9.
2000: Jeffrey L Evelhoch; Robert J Gillies; Gregory S Karczmar; Jason A Koutcher; Ross J Maxwell; O Nalcioglu; Natarajan Raghunand; Sabrina M Ronen; Brian D Ross; H M Swartz
Applications of magnetic resonance in model systems: cancer therapeutics.
Neoplasia (New York, N.Y.) 2000;2(1-2):152-65.
2000: Robert J Gillies; Zaver M Bhujwalla; Jeffrey L Evelhoch; M Garwood; Michal Neeman; S P Robinson; C H Sotak; Boudewijn van der Sanden
Applications of magnetic resonance in model systems: tumor biology and physiology.
Neoplasia (New York, N.Y.) 2000;2(1-2):139-51.
1999: Robert J Gillies; P A Schornack; Timothy W Secomb; Natarajan Raghunand
Causes and effects of heterogeneous perfusion in tumors.
Neoplasia (New York, N.Y.) 1999;1(3):197-207.
1999: Jean-Philippe Galons; Maria I Altbach; Gillian Paine-Murrieta; Charles W Taylor; Robert J Gillies
Early increases in breast tumor xenograft water mobility in response to paclitaxel therapy detected by non-invasive diffusion magnetic resonance imaging.
Neoplasia (New York, N.Y.) 1999;1(2):113-7.
1999: Natarajan Raghunand; X He; R van Sluis; Brent P Mahoney; Brenda Baggett; Charles W Taylor; Gillian Paine-Murrieta; D Roe; Zaver M Bhujwalla; Robert J Gillies
Enhancement of chemotherapy by manipulation of tumour pH.
British journal of cancer 1999;80(7):1005-11.
1999: Natarajan Raghunand; Raul Martinez-Zaguilan; S H Wright; Robert J Gillies
pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs.
Biochemical pharmacology 1999;57(9):1047-58.
1999: Raul Martinez-Zaguilan; Natarajan Raghunand; Ronald M Lynch; William T Bellamy; Gloria M Martinez; B Rojas; D Smith; W S Dalton; Robert J Gillies
pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines.
Biochemical pharmacology 1999;57(9):1037-46.
1999: Zaver M Bhujwalla; EO Aboagye; Robert J Gillies; Vadappuram P Chacko; CE Mendola; Joseph M Backer
Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitro.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;41(5):897-903.
1999: R van Sluis; Zaver M Bhujwalla; Natarajan Raghunand; Paloma Ballesteros; J Alvarez; Sebastián Cerdán; Jean-Philippe Galons; Robert J Gillies
In vivo imaging of extracellular pH using 1H MRSI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;41(4):743-50.
1999: Natarajan Raghunand; Maria I Altbach; R van Sluis; Brenda Baggett; Charles W Taylor; Zaver M Bhujwalla; Robert J Gillies
Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy.
Biochemical pharmacology 1999;57(3):309-12.
1999: Raul Martinez-Zaguilan; Linda S Tompkins; Robert J Gillies; Ronald M Lynch
Simultaneous analysis of intracellular pH and Ca2+ from cell populations.
Methods in molecular biology (Clifton, N.J.) 1999;114():287-306.
1998: Zaver M Bhujwalla; C L McCoy; Jerry D Glickson; Robert J Gillies; Marion Stubbs
Estimations of intra- and extracellular volume and pH by 31P magnetic resonance spectroscopy: effect of therapy on RIF-1 tumours.
British journal of cancer 1998;78(5):606-11.
1998: Raul Martinez-Zaguilan; Gloria M Martinez; A Gomez; Mary J C Hendrix; Robert J Gillies
Distinct regulation of pHin and [Ca2+]in in human melanoma cells with different metastatic potential.
Journal of cellular physiology 1998;176(1):196-205.
1996: N R Aiken; Robert J Gillies
Phosphomonoester metabolism as a function of cell proliferative status and exogenous precursors.
Anticancer research 1996;16(3B):1393-7.
1996: Raul Martinez-Zaguilan; Elisabeth A Seftor; Richard E B Seftor; Y W Chu; Robert J Gillies; Mary J C Hendrix
Acidic pH enhances the invasive behavior of human melanoma cells.
Clinical & experimental metastasis 1996;14(2):176-86.
1995: Yeong-Hau H Lien; X Wang; Robert J Gillies; Raul Martinez-Zaguilan
Modulation of intracellular Ca2+ by glucose in MDCK cells: role of endoplasmic reticulum Ca(2+)-ATPase.
The American journal of physiology 1995;268(4 Pt 2):F671-9.
1995: Jean-Philippe Galons; C Job; Robert J Gillies
Increase of GPC levels in cultured mammalian cells during acidosis. A 31P MR spectroscopy study using a continuous bioreactor system.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1995;33(3):422-6.
1994: J M Gunn; Raul Martinez-Zaguilan; S Wald-Hopkins; D Woolridge; Robert J Gillies
NIH3T3 cells transfected with the yeast H(+)-ATPase have altered rates of protein turnover.
Archives of biochemistry and biophysics 1994;314(2):268-75.
1994: Raul Martinez-Zaguilan; J A Wegner; Robert J Gillies; Patricia B Hoyer
Differential regulation of Ca2+ homeostasis in ovine large and small luteal cells.
Endocrinology 1994;135(5):2099-108.
1994: A M Wysynski; Raul Martinez-Zaguilan; C Alden; A Gandolfi; Robert J Gillies
Phenobarbital induces cytosolic acidification in an established liver epithelial cell line.
Toxicology letters 1994;74(2):157-66.
1994: G M Martínez; Raul Martinez-Zaguilan; Robert J Gillies
Effect of glucose on pHin and [Ca2+]in in NIH-3T3 cells transfected with the yeast P-type H(+)-ATPase.
Journal of cellular physiology 1994;161(1):129-41.
1994: Robert J Gillies; J A Barry; Brian D Ross
In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1994;32(3):310-8.
1994: D Lax; Raul Martinez-Zaguilan; Robert J Gillies
Furazolidone increases thapsigargin-sensitive Ca(2+)-ATPase in chick cardiac myocytes.
The American journal of physiology 1994;267(2 Pt 2):H734-41.
1994: Robert J Gillies; Z Liu; Zaver M Bhujwalla
31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate.
The American journal of physiology 1994;267(1 Pt 1):C195-203.
1994: E P Peterson; Gloria M Martinez; Raul Martinez-Zaguilan; R Perona; Robert J Gillies
NIH 3T3 cells transfected with a yeast H(+)-ATPase have altered sensitivity to insulin, insulin growth factor-I, and platelet-derived growth factor-AA.
Journal of cellular physiology 1994;159(3):551-60.
1994: Raul Martinez-Zaguilan; Robert J Gillies; S Sánchez-Armass
Regulation of pH in rat brain synaptosomes. II. Role of Cl-.
Journal of neurophysiology 1994;71(6):2249-57.
1994: S Sánchez-Armass; Raul Martinez-Zaguilan; G M Martínez; Robert J Gillies
Regulation of pH in rat brain synaptosomes. I. Role of sodium, bicarbonate, and potassium.
Journal of neurophysiology 1994;71(6):2236-48.
1994: J A Wegner; Raul Martinez-Zaguilan; Robert J Gillies; Patricia B Hoyer
Prostaglandin F2 alpha releases calcium from a thapsigargin-sensitive pool in ovine large luteal cells.
The American journal of physiology 1994;266(1 Pt 1):E50-6.
1993: Raul Martinez-Zaguilan; Ronald M Lynch; Gloria M Martinez; Robert J Gillies
Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells.
The American journal of physiology 1993;265(4 Pt 1):C1015-29.
1993: J A Barry; K A McGovern; Yeong-Hau H Lien; B Ashmore; Robert J Gillies
Dimethyl methylphosphonate (DMMP): a 31P nuclear magnetic resonance spectroscopic probe of intracellular volume in mammalian cell cultures.
Biochemistry 1993;32(17):4665-70.
1993: Robert J Gillies; Jean-Philippe Galons; K A McGovern; P G Scherer; Yeong-Hau H Lien; C Job; R Ratcliff; F Chapa; S Cerdan; B E Dale
Design and application of NMR-compatible bioreactor circuits for extended perfusion of high-density mammalian cell cultures.
NMR in biomedicine 1993;6(1):95-104.
1992: Raul Martinez-Zaguilan; Robert J Gillies
A plasma membrane V-type H(+)-ATPase may contribute to elevated intracellular pH (pHin) in some human tumor cells.
Annals of the New York Academy of Sciences 1992;671():478-80.
1992: Yeong-Hau H Lien; H Z Zhou; C Job; J A Barry; Robert J Gillies
In vivo 31P NMR study of early cellular responses to hyperosmotic shock in cultured glioma cells.
Biochimie 1992;74(9-10):931-9.
1991: Robert J Gillies; P G Scherer; Natarajan Raghunand; L S Okerlund; Raul Martinez-Zaguilan; L Hesterberg; B E Dale
Iteration of hybridoma growth and productivity in hollow fiber bioreactors using 31P NMR.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1991;18(1):181-92.
1991: Raul Martinez-Zaguilan; G M Martínez; F Lattanzio; Robert J Gillies
Simultaneous measurement of intracellular pH and Ca2+ using the fluorescence of SNARF-1 and fura-2.
The American journal of physiology 1991;260(2 Pt 1):C297-307.
1991: J A Wegner; Raul Martinez-Zaguilan; Robert J Gillies; Patricia B Hoyer
Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: II. Modulation of the transient and resting cytosolic free calcium alters progesterone secretion.
Endocrinology 1991;128(2):929-36.
1991: Robert J Gillies; Raul Martinez-Zaguilan
Regulation of intracellular pH in BALB/c 3T3 cells. Bicarbonate raises pH via NaHCO3/HCl exchange and attenuates the activation of Na+/H+ exchange by serum.
The Journal of biological chemistry 1991;266(3):1551-6.
1991: B E Dale; Robert J Gillies
Nuclear magnetic resonance spectroscopy of dense cell populations for metabolic studies and bioreactor engineering: a synergistic partnership.
Biotechnology (Reading, Mass.) 1991;17():107-18.
1990: J A Wegner; Raul Martinez-Zaguilan; ME Wise; Robert J Gillies; Patricia B Hoyer
Prostaglandin F2 alpha-induced calcium transient in ovine large luteal cells: I. Alterations in cytosolic-free calcium levels and calcium flux.
Endocrinology 1990;127(6):3029-37.
1990: Robert J Gillies; Raul Martinez-Zaguilan; Gloria M Martinez; R Serrano; R Perona
Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7414-8.
1989: Raul Martinez-Zaguilan; Robert J Gillies
Dimethylsulfoxide modifies the sensitivity of BALB/c-3T3 cells to the activation of Na+/H+ exchange by phorbol esters.
Journal of cellular physiology 1989;139(1):131-5.
1989: Robert J Gillies; Raul Martinez-Zaguilan; J M Sneider; Patricia B Hoyer
Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced, activation of Na+/H+ exchange in mammalian cells.
Journal of cellular physiology 1989;139(1):125-30.
1988: C A Lucas; Robert J Gillies; J E Olson; K A Giuliano; Raul Martinez-Zaguilan; J M Sneider
Intracellular acidification inhibits the proliferative response in BALB/c-3T3 cells.
Journal of cellular physiology 1988;136(1):161-7.
1988: Raul Martinez-Zaguilan; Robert J Gillies; K A Giuliano
Effect of serum on the intracellular pH of BALB/c-3T3 cells: serum deprivation causes changes in sensitivity of cells to serum.
Journal of cellular physiology 1988;136(1):154-60.
1987: K A Giuliano; Robert J Gillies
Determination of intracellular pH of BALB/c-3T3 cells using the fluorescence of pyranine.
Analytical biochemistry 1987;167(2):362-71.
1987: Robert J Gillies; J Cook; M H Fox; K A Giuliano
Flow cytometric analysis of intracellular pH in 3T3 cells.
The American journal of physiology 1987;253(1 Pt 1):C121-5.