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Chaim Gilon

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Johannes G Beck; Jayanta Chatterjee; Andreas O Frank; Chaim Gilon; Sarit Greenberg; Amnon Hoffman; Marelli Udaya Kiran; Burkhardt Laufer; Stefanie Neubauer; Oded Ovadia; Horst Kessler
Intestinal permeability of cyclic peptides: common key backbone motifs identified.
Zvi Hayouka; Mattan Hurevich; Aviad Levin; Abraham Loyter; Deborah E Shalev; Chaim Gilon; Assaf Friedler
A comparative study of backbone versus side chain peptide cyclization: application for HIV-1 integrase inhibitors.
Ehud Horwitz; Mervyn Shapiro; Yftah Tal-Gan; Violetta Temper; Chaim Gilon; Amnon Hoffman
Chemical trapping of vancomycin: a potential strategy for preventing selection of vancomycin-resistant Enterococci.

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2012: Johannes G Beck; Jayanta Chatterjee; Andreas O Frank; Chaim Gilon; Sarit Greenberg; Amnon Hoffman; Marelli Udaya Kiran; Burkhardt Laufer; Stefanie Neubauer; Oded Ovadia; Horst Kessler
Intestinal permeability of cyclic peptides: common key backbone motifs identified.
Journal of the American Chemical Society 2012;134(29):12125-33.
2012: Zvi Hayouka; Mattan Hurevich; Aviad Levin; Abraham Loyter; Deborah E Shalev; Chaim Gilon; Assaf Friedler
A comparative study of backbone versus side chain peptide cyclization: application for HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry 2012;20(10):3317-22.
2012: Ehud Horwitz; Mervyn Shapiro; Yftah Tal-Gan; Violetta Temper; Chaim Gilon; Amnon Hoffman
Chemical trapping of vancomycin: a potential strategy for preventing selection of vancomycin-resistant Enterococci.
Microbial drug resistance (Larchmont, N.Y.) 2012;18(2):109-15.
2012: Yftah Tal-Gan; Shoshana Klein; Alexander Levitzki; Ofra Moshel; Shirly Naveh; Chaim Gilon
Studying protein-peptide interactions using benzophenone units: a case study of protein kinase B/Akt and its inhibitor PTR6154.
Analytical biochemistry 2012;421(2):750-4.
2011: Yftah Tal-Gan; Noam S Freeman; Shoshana Klein; Alexander Levitzki; Chaim Gilon
Metabolic stability of peptidomimetics: N-methyl and aza heptapeptide analogs of a PKB/Akt inhibitor.
Chemical biology & drug design 2011;78(5):887-92.
2011: Yftah Tal-Gan; Avraham Ben-Shimon; Carina Hazan; Mattan Hurevich; Shoshana Klein; Alexander Levitzki; Masha Y Niv; David Rosenthal; Deborah E Shalev; Chaim Gilon
Backbone cyclic peptide inhibitors of protein kinase B (PKB/Akt).
Journal of medicinal chemistry 2011;54(14):5154-64.
2011: Noam S Freeman; Yftah Tal-Gan; Shoshana Klein; Alexander Levitzki; Chaim Gilon
Microwave-assisted solid-phase aza-peptide synthesis: aza scan of a PKB/Akt inhibitor using aza-arginine and aza-proline precursors.
The Journal of organic chemistry 2011;76(9):3078-85.
2011: Oded Ovadia; Sarit Greenberg; Jayanta Chatterjee; Burkhardt Laufer; Florian Opperer; Horst Kessler; Chaim Gilon; Amnon Hoffman
The effect of multiple N-methylation on intestinal permeability of cyclic hexapeptides.
Molecular pharmaceutics 2011;8(2):479-87.
2011: Peleg Astrahan; Ravenna Flitman-Tene; Estelle R Bennett; Miriam Krugliak; Chaim Gilon; Isaiah T Arkin
Quantitative analysis of influenza M2 channel blockers.
Biochimica et biophysica acta 2011;1808(1):394-8.
2010: Zvi Hayouka; Mattan Hurevich; Aviad Levin; Hadar Benyamini; Anat Iosub; Michal Maes; Deborah E Shalev; Abraham Loyter; Chaim Gilon; Assaf Friedler
Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein.
Bioorganic & medicinal chemistry 2010;18(23):8388-95.
2010: Mattan Hurevich; Avi Swed; Salim Joubran; Shira Cohen; Noam S Freeman; Elena Britan-Rosich; Laurence Briant-Longuet; Martine Bardy; Christian Devaux; Moshe Kotler; Amnon Hoffman; Chaim Gilon
Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule: the HIV-1 CD4:gp120 paradigm.
Bioorganic & medicinal chemistry 2010;18(15):5754-61.
2010: Oded Ovadia; Burkhardt Laufer; Chaim Gilon; Sarit Greenberg; Amnon Hoffman; Horst Kessler
Improvement of drug-like properties of peptides: the somatostatin paradigm.
Expert opinion on drug discovery 2010;5(7):655-71.
2010: Yftah Tal-Gan; Noam S Freeman; Shoshana Klein; Alexander Levitzki; Chaim Gilon
Synthesis and structure-activity relationship studies of peptidomimetic PKB/Akt inhibitors: the significance of backbone interactions.
Bioorganic & medicinal chemistry 2010;18(8):2976-85.
2010: Mattan Hurevich; Yftah Tal-Gan; Shoshana Klein; Yaniv Barda; Alexander Levitzki; Chaim Gilon
Novel method for the synthesis of urea backbone cyclic peptides using new Alloc-protected glycine building units.
Journal of peptide science : an official publication of the European Peptide Society 2010;16(4):178-85.
2010: Oded Ovadia; Yaniv Linde; Carrie Haskell-Luevano; Marvin L Dirain; Tanya Sheynis; Raz Jelinek; Chaim Gilon; Amnon Hoffman
The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm.
Bioorganic & medicinal chemistry 2010;18(2):580-9.
2009: Nir Qvit; Ada Hatzubai; Deborah E Shalev; Assaf Friedler; Yinon Ben-Neriah; Chaim Gilon
Design and synthesis of backbone cyclic phosphorylated peptides: The IkappaB model.
Biopolymers 2009;91(2):157-68.
2009: Horst Kessler; Jayanta Chatterjee; Lucas Doedens; Florian Operrer; Eric Biron; Daniel Hoyer; Herbert Schmid; Chaim Gilon; Victor J Hruby; Dale F Mierkes
New perspective in peptide chemistry by N-alkylation.
Advances in experimental medicine and biology 2009;611():229-31.
2009: Jayanta Chatterjee; Oded Ovadia; Grit Zahn; Luciana Marinelli; Amnon Hoffman; Chaim Gilon; Horst Kessler
Highly selective cyclic hexapeptides antagonist of GPIIb-IIIa by multiple N-methylation.
Advances in experimental medicine and biology 2009;611():209-10.
2009: Nir Qvit; Ada Hatzubai; Deborah E Shalev; Yinon Ben-Neriah; Chaim Gilon
Design and synthesis of backbone cyclic phosphopeptides: the IkappaB model.
Advances in experimental medicine and biology 2009;611():139-40.
2009: Jayanta Chatterjee; Oded Ovadia; Chaim Gilon; Amnon Hoffman; Dale Mierke; Horst Kessler
N-methylated cyclic pentapeptides as template structures.
Advances in experimental medicine and biology 2009;611():109-10.
2008: Jayanta Chatterjee; Chaim Gilon; Amnon Hoffman; Horst Kessler
N-methylation of peptides: a new perspective in medicinal chemistry.
Accounts of chemical research 2008;41(10):1331-42.
2008: Nir Qvit; Hadas Reuveni; Sharon Gazal; Adi Zundelevich; Galia Blum; Masha Y Niv; Alexandra Feldstein; Sharon Meushar; Deborah E Shalev; Assaf Friedler; Chaim Gilon
Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor.
Journal of combinatorial chemistry 2008;10(2):256-66.
2008: Shmuel Hess; Yaniv Linde; Oded Ovadia; Eli Safrai; Deborah E Shalev; Avi Swed; Efrat Halbfinger; Tair Lapidot; Ilan Winkler; Yael Gabinet; Avi Faier; Dana Yarden; Zhimin Xiang; Federico P Portillo; Carrie Haskell-Luevano; Chaim Gilon; Amnon Hoffman
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity.
Journal of medicinal chemistry 2008;51(4):1026-34.
2008: Yaniv Linde; Oded Ovadia; Eli Safrai; Zhimin Xiang; Federico P Portillo; Deborah E Shalev; Carrie Haskell-Luevano; Amnon Hoffman; Chaim Gilon
Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides.
Biopolymers 2008;90(5):671-82.
2008: Nir Qvit; Galya Monderer-Rothkoff; Ayelet Ido; Deborah E Shalev; Orna Amster-Choder; Chaim Gilon
Development of bifunctional photoactivatable benzophenone probes and their application to glycoside substrates.
Biopolymers 2008;90(4):526-36.
2008: Eric Biron; Jayanta Chatterjee; Oded Ovadia; Daniel Langenegger; Joseph Brueggen; Daniel Hoyer; Herbert A Schmid; Raz Jelinek; Chaim Gilon; Amnon Hoffman; Horst Kessler
Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.
Angewandte Chemie (International ed. in English) 2008;47(14):2595-9.
2007: Shmuel Hess; Oded Ovadia; Deborah E Shalev; Hanoch Senderovich; Bashir Qadri; Tamar Yehezkel; Yoseph Salitra; Tania Sheynis; Raz Jelinek; Chaim Gilon; Amnon Hoffman
Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability.
Journal of medicinal chemistry 2007;50(24):6201-11.
2007: Jayanta Chatterjee; Oded Ovadia; Grit Zahn; Luciana Marinelli; Amnon Hoffman; Chaim Gilon; Horst Kessler
Multiple N-methylation by a designed approach enhances receptor selectivity.
Journal of medicinal chemistry 2007;50(24):5878-81.
2006: Gil Fridkin; Shai Rahimipour; Nurit Ben-Aroya; Aviva Kapitkovsky; Susanna Di-Segni; Masha Rosenberg; Irina Kustanovich; Yitzhak Koch; Chaim Gilon; Mati Fridkin
Novel cyclic azo-bridged analogs of gonadotropin-releasing hormone.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(2):106-15.
2005: Elana Hariton-Gazal; Joseph Rosenbluh; Nehama Zakai; Gil Fridkin; Ruth Brack-Werner; Horst Wolff; Christian Devaux; Chaim Gilon; Abraham Loyter
Functional analysis of backbone cyclic peptides bearing the arm domain of the HIV-1 Rev protein: characterization of the karyophilic properties and inhibition of Rev-induced gene expression.
Biochemistry 2005;44(34):11555-66.
2005: Gil Fridkin; Thomas A Bonasera; Pninit Litman; Chaim Gilon
Backbone metal-cyclization: a novel approach for simultaneous peptide cyclization and radiolabeling. Application to the combinatorial synthesis of rhenium-cyclic somatostatin analogs.
Nuclear medicine and biology 2005;32(1):39-50.
2004: Yaniv Barda; Nasi Cohen; Vered Lev; Nurit Ben-Aroya; Yitzhak Koch; Eyal Mishani; Mati Fridkin; Chaim Gilon
Backbone metal cyclization: novel 99mTc labeled GnRH analog as potential SPECT molecular imaging agent in cancer.
Nuclear medicine and biology 2004;31(7):921-33.
2003: Sharon Gazal; Gary Gellerman; Chaim Gilon
Novel Gly building units for backbone cyclization: synthesis and incorporation into model peptides.
Peptides 2003;24(12):1847-52.
2003: Elana Hariton-Gazal; Joseph Rosenbluh; Adolf Graessmann; Chaim Gilon; Abraham Loyter
Direct translocation of histone molecules across cell membranes.
Journal of cell science 2003;116(Pt 22):4577-86.
2003: C Grach; Y Wang; Yaniv Barda; Chaim Gilon; Meir Paul Pener
In vivo structure-activity studies on the dark-color-inducing neurohormone of locusts.
The journal of peptide research : official journal of the American Peptide Society 2003;62(3):135-42.
2003: C Grach; Y Wang; Yaniv Barda; Chaim Gilon; Meir Paul Pener
In vivo structure-activity studies on the dark-color-inducing neurohormone of locusts.
The journal of peptide research : official journal of the American Peptide Society 2003;62(1):37-44.
2002: Lea Baraz; Marina Hutoran; Immanuel Blumenzweig; Mark Katzenellenbogen; Assaf Friedler; Chaim Gilon; Michael Steinitz; Moshe Kotler
Human immunodeficiency virus type 1 Vif binds the viral protease by interaction with its N-terminal region.
The Journal of general virology 2002;83(Pt 9):2225-30.
2002: Yoram Yerushalmi; Kalpana Bhargava; Chaim Gilon; Meir Paul Pener
Structure-activity relations of the dark-colour-inducing neurohormone of locusts.
Insect biochemistry and molecular biology 2002;32(8):909-17.
2002: Gil Fridkin; Chaim Gilon
Azo cyclization: peptide cyclization via azo bridge formation.
The journal of peptide research : official journal of the American Peptide Society 2002;60(2):104-11.
2002: Elana Hariton-Gazal; Rina Feder; Amram Mor; Adolf Graessmann; Ruth Brack-Werner; David Jans; Chaim Gilon; Abraham Loyter
Targeting of nonkaryophilic cell-permeable peptides into the nuclei of intact cells by covalently attached nuclear localization signals.
Biochemistry 2002;41(29):9208-14.
2002: Immanuel Blumenzweig; Lea Baraz; Assaf Friedler; Helena Danielson; Chaim Gilon; Michael Steinitz; Moshe Kotler
HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases.
Biochemical and biophysical research communications 2002;292(4):832-40.
2002: Sharon Gazal; Garry Gelerman; Ofer Ziv; Olga Karpov; Pninit Litman; Moshe Bracha; Michel Afargan; Chaim Gilon
Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units.
Journal of medicinal chemistry 2002;45(8):1665-71.
2002: Elana Hariton-Gazal; Dorit Friedler; Assaf Friedler; Nehama Zakai; Chaim Gilon; Abraham Loyter
Inhibition of nuclear import by backbone cyclic peptidomimetics derived from the HIV-1 MA NLS sequence.
Biochimica et biophysica acta 2002;1594(2):234-42.
2001: Sharon Gazal; Gary Gellerman; E Glukhov; Chaim Gilon
Synthesis of novel protected Nalpha(omega-thioalkyl) amino acid building units and their incorporation in backbone cyclic disulfide and thioetheric bridged peptides.
The journal of peptide research : official journal of the American Peptide Society 2001;58(6):527-39.
2001: S Jiang; Sharon Gazal; Garry Gelerman; Ofer Ziv; Olga Karpov; Pninit Litman; Moshe Bracha; Michel Afargan; Chaim Gilon; Murray Goodman
A bioactive somatostatin analog without a type II' beta-turn: synthesis and conformational analysis in solution.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(10):521-8.
2001: Irina Zeltser; Orna Ben-Aziz; I Schefler; Kalpana Bhargava; Miriam Altstein; Chaim Gilon
Insect neuropeptide antagonist. Part II. Synthesis and biological activity of backbone cyclic and precyclic PBAN antagonists.
The journal of peptide research : official journal of the American Peptide Society 2001;58(4):275-84.
2001: Miriam Altstein; Orna Ben-Aziz; S Daniel; Irina Zeltser; Chaim Gilon
Pyrokinin/PBAN radio-receptor assay: development and application for the characterization of a putative receptor from the pheromone gland of Heliothis peltigera.
Peptides 2001;22(9):1379-89.
2001: Gil Fridkin; Chaim Gilon; T Gilon; Abraham Loyter
Systematic solid-phase synthesis of linear pseudooligolysines containing multiple adjacent CH(2)NH amide bond surrogates: potential agents for gene delivery.
The journal of peptide research : official journal of the American Peptide Society 2001;58(1):36-44.
2001: Michel Afargan; E T Janson; Garry Gelerman; R Rosenfeld; Ofer Ziv; Olga Karpov; A Wolf; Moshe Bracha; D Shohat; G Liapakis; Chaim Gilon; A Hoffman; D Stephensky; K Oberg
Novel long-acting somatostatin analog with endocrine selectivity: potent suppression of growth hormone but not of insulin.
Endocrinology 2001;142(1):477-86.
2000: Irina Zeltser; Chaim Gilon; Orna Ben-Aziz; I Schefler; Miriam Altstein
Discovery of a linear lead antagonist to the insect pheromone biosynthesis activating neuropeptide (PBAN).
Peptides 2000;21(10):1457-65.
2000: Assaf Friedler; Dorit Friedler; Nathan W Luedtke; Yitzhak Tor; Abraham Loyter; Chaim Gilon
Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif.
The Journal of biological chemistry 2000;275(31):23783-9.
1999: R Kasher; D A Oren; Yaniv Barda; Chaim Gilon
Miniaturized proteins: the backbone cyclic proteinomimetic approach.
Journal of molecular biology 1999;292(2):421-9.
1999: Miriam Altstein; Orna Ben-Aziz; S Daniel; I Schefler; Irina Zeltser; Chaim Gilon
Backbone cyclic peptide antagonists, derived from the insect pheromone biosynthesis activating neuropeptide, inhibit sex pheromone biosynthesis in moths.
The Journal of biological chemistry 1999;274(25):17573-9.
1999: Assaf Friedler; Nehama Zakai; Osnat Karni; Dorit Friedler; Chaim Gilon; Abraham Loyter
Identification of a nuclear transport inhibitory signal (NTIS) in the basic domain of HIV-1 Vif protein.
Journal of molecular biology 1999;289(3):431-7.
1999: Assaf Friedler; Immanuel Blumenzweig; Lea Baraz; Michael Steinitz; Moshe Kotler; Chaim Gilon
Peptides derived from HIV-1 Vif: a non-substrate based novel type of HIV-1 protease inhibitors.
Journal of molecular biology 1999;287(1):93-101.
1999: Miriam Altstein; T Gabay; Orna Ben-Aziz; S Daniel; Irina Zeltser; Chaim Gilon
Characterization of a putative pheromone biosynthesis-activating neuropeptide (PBAN) receptor from the pheromone gland of Heliothis peltigera.
Invertebrate neuroscience : IN 1999;4(1):33-40.
1998: Lea Baraz; Assaf Friedler; Immanuel Blumenzweig; O Nussinuv; N Chen; Michael Steinitz; Chaim Gilon; Moshe Kotler
Human immunodeficiency virus type 1 Vif-derived peptides inhibit the viral protease and arrest virus production.
FEBS letters 1998;441(3):419-26.
1998: Osnat Karni; Assaf Friedler; Nehama Zakai; Chaim Gilon; Abraham Loyter
A peptide derived from the N-terminal region of HIV-1 Vpr promotes nuclear import in permeabilized cells: elucidation of the NLS region of the Vpr.
FEBS letters 1998;429(3):421-5.
1998: Assaf Friedler; Nehama Zakai; Osnat Karni; Y C Broder; Lea Baraz; Moshe Kotler; Abraham Loyter; Chaim Gilon
Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells.
Biochemistry 1998;37(16):5616-22.
1998: Chaim Gilon; M Huenges; B Mathä; Gary Gellerman; V Hornik; Michel Afargan; O Amitay; Ofer Ziv; E Feller; A Gamliel; D Shohat; M Wanger; O Arad; H Kessler
A backbone-cyclic, receptor 5-selective somatostatin analogue: synthesis, bioactivity, and nuclear magnetic resonance conformational analysis.
Journal of medicinal chemistry 1998;41(6):919-29.
1997: Y C Broder; Ariel Stanhill; Nehama Zakai; Assaf Friedler; Chaim Gilon; Abraham Loyter
Translocation of NLS-BSA conjugates into nuclei of permeabilized mammalian cells can be supported by protoplast extract. An experimental system for studying plant cytosolic factors involved in nuclear import.
FEBS letters 1997;412(3):535-9.
1997: Gal Bitan; Inna Sukhotinsky; Yaffa Mashriki; Menachem Hanani; Zvi Selinger; Chaim Gilon
Synthesis and biological activity of novel backbone-bicyclic substance-P analogs containing lactam and disulfide bridges.
The journal of peptide research : official journal of the American Peptide Society 1997;49(5):421-6.
1997: Hadas Reuveni; A Gitler; E Poradosu; Chaim Gilon; Alexander Levitzki
Synthesis and biological activity of semipeptoid farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry 1997;5(1):85-92.
1996: Aviv Gazit; N Osherov; Chaim Gilon; Alexander Levitzki
Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro.
Journal of medicinal chemistry 1996;39(25):4905-11.
1996: S Behrens; B Mathä; Gal Bitan; Chaim Gilon; H Kessler
Structure-activity relationship of the ring portion in backbone-cyclic C-terminal hexapeptide analogs of substance P. NMR and molecular dynamics.
International journal of peptide and protein research 1996;48(6):569-79.
1996: G Byk; David Halle; Irina Zeltser; Gal Bitan; Zvi Selinger; Chaim Gilon
Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P.
Journal of medicinal chemistry 1996;39(16):3174-8.
1996: Gal Bitan; Irina Zeltser; G Byk; David Halle; Y Mashriki; E V Gluhov; I Sukhotinsky; Menachem Hanani; Zvi Selinger; Chaim Gilon
Backbone cyclization of the C-terminal part of substance P. Part 1: The important role of the sulphur in position 11.
Journal of peptide science : an official publication of the European Peptide Society 1996;2(4):261-9.
1994: Simona Golic Grdadolnik; D F Mierke; G Byk; Irina Zeltser; Chaim Gilon; Horst Kessler
Comparison of the conformation of active and nonactive backbone cyclic analogs of substance P as a tool to elucidate features of the bioactive conformation: NMR and molecular dynamics in DMSO and water.
Journal of medicinal chemistry 1994;37(14):2145-52.
1993: Aviv Gazit; N Osherov; I Posner; A Bar-Sinai; Chaim Gilon; Alexander Levitzki
Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Journal of medicinal chemistry 1993;36(23):3556-64.
1993: M Anafi; Aviv Gazit; Chaim Gilon; Y B Neriah; Alexander Levitzki
Tyrphostin-induced differentiation of mouse erythroleukemia cells.
FEBS letters 1993;330(3):260-4.
1993: N Osherov; Aviv Gazit; Chaim Gilon; Alexander Levitzki
Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins.
The Journal of biological chemistry 1993;268(15):11134-42.
1992: D Ron; Chaim Gilon; Menachem Hanani; Amos Vromen; Zvi Selinger; Michael Chorev
N-methylated analogs of Ac[Nle28,31]CCK(26-33): synthesis, activity, and receptor selectivity.
Journal of medicinal chemistry 1992;35(15):2806-11.
1992: Tova Volberg; Yehiel Zick; R Dror; I Sabanay; Chaim Gilon; Alexander Levitzki; Benjamin Geiger
The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.
The EMBO journal 1992;11(5):1733-42.
1992: M Anafi; Aviv Gazit; Chaim Gilon; Yinon Ben-Neriah; Alexander Levitzki
Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins.
The Journal of biological chemistry 1992;267(7):4518-23.
1991: E Roubini; R Laufer; Chaim Gilon; Zvi Selinger; B P Roques; Michael Chorev
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
Journal of medicinal chemistry 1991;34(8):2430-8.
1991: Aviv Gazit; N Osherov; I Posner; P Yaish; E Poradosu; Chaim Gilon; Alexander Levitzki
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Journal of medicinal chemistry 1991;34(6):1896-907.
1991: Chaim Gilon; David Halle; Michael Chorev; Zvi Selinger; G Byk
Backbone cyclization: A new method for conferring conformational constraint on peptides.
Biopolymers 1991;31(6):745-50.
1991: Michael Chorev; E Roubini; Chaim Gilon; Zvi Selinger
Toward nonpeptidal substance P mimetic analogues: design, synthesis, and biological activity.
Biopolymers 1991;31(6):725-33.
1991: A Dvir; Yoram Milner; O Chomsky; Chaim Gilon; Aviv Gazit; Alexander Levitzki
The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.
The Journal of cell biology 1991;113(4):857-65.
1991: G Stavropoulos; K Karagiannis; Paul Cordopatis; David Halle; Chaim Gilon; G Bar-Akiva; Zvi Selinger; Michael Chorev
Synthesis and biological activity of substance P C-terminal hexapeptide and heptapeptide analogues.
International journal of peptide and protein research 1991;37(3):180-4.
1991: Alexander Levitzki; Aviv Gazit; N Osherov; I Posner; Chaim Gilon
Inhibition of protein-tyrosine kinases by tyrphostins.
Methods in enzymology 1991;201():347-61.
1990: D Papir-Kricheli; Chaim Gilon; Michael Chorev; Zvi Selinger; Marshall Devor
Neurochemical mediators of the behavioural effects of receptor-selective substance P agonists administered intrathecally in the rat.
Neuropharmacology 1990;29(11):1055-65.
1990: Uri Wormser; R Laufer; Michael Chorev; Chaim Gilon; Zvi Selinger
Proteolytic resistance and biological activity of N-methylated analogs of [pGlu6] substance P6-11.
Neuropeptides 1990;16(1):41-9.
1989: I Posner; Aviv Gazit; Chaim Gilon; Alexander Levitzki
Tyrphostins inhibit the epidermal growth factor receptor-mediated breakdown of phosphoinositides.
FEBS letters 1989;257(2):287-91.
1989: Aviv Gazit; P Yaish; Chaim Gilon; Alexander Levitzki
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
Journal of medicinal chemistry 1989;32(10):2344-52.
1989: Marshall Devor; D Papir-Kricheli; E Nachmias; F Rosenthal; Chaim Gilon; Michael Chorev; Zvi Selinger
Substance P-induced cutaneous plasma extravasation in rats is mediated by NK-1 tachykinin receptors.
Neuroscience letters 1989;103(2):203-8.
1989: Yoram Shechter; P Yaish; M Chorev; Chaim Gilon; S Braun; Alexander Levitzki
Inhibition of insulin-dependent lipogenesis and anti-lipolysis by protein tyrosine kinase inhibitors.
The EMBO journal 1989;8(6):1671-6.
1988: P Yaish; Aviv Gazit; Chaim Gilon; Alexander Levitzki
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.
Science (New York, N.Y.) 1988;242(4880):933-5.
1988: Menachem Hanani; Michael Chorev; Chaim Gilon; Zvi Selinger
The actions of receptor-selective substance P analogs on myenteric neurons: an electrophysiological investigation.
European journal of pharmacology 1988;153(2-3):247-53.
1988: R Laufer; Chaim Gilon; Michael Chorev; Zvi Selinger
Desensitization with a selective agonist discriminates between multiple tachykinin receptors.
The Journal of pharmacology and experimental therapeutics 1988;245(2):639-43.
1988: Ariel Ewenson; R Laufer; Michael Chorev; Zvi Selinger; Chaim Gilon
Dehydro keto methylene and keto methylene analogues of substance P. Synthesis and biological activity.
Journal of medicinal chemistry 1988;31(2):416-21.
1988: P Silkoff; Fanny Karmeli; Eran Goldin; Ariel Ewenson; Chaim Gilon; Michael Chorev; R Laufer; Zvi Selinger; Daniel Rachmilewitz
Effect of substance P on rat gastrointestinal transit.
Digestive diseases and sciences 1988;33(1):74-7.
1987: D Papir-Kricheli; J Frey; R Laufer; Chaim Gilon; Michael Chorev; Zvi Selinger; Marshall Devor
Behavioural effects of receptor-specific substance P agonists.
Pain 1987;31(2):263-76.
1986: Uri Wormser; R Laufer; Y Hart; Michael Chorev; Chaim Gilon; Zvi Selinger
Highly selective agonists for substance P receptor subtypes.
The EMBO journal 1986;5(11):2805-8.
1986: Michael Chorev; E Rubini; Y Hart; Chaim Gilon; Uri Wormser; Zvi Selinger
Metabolically stable analogues of substance P: persistent action of partially modified retro-inverso analogues of substance P on rat parotid and hypothalamic slices.
European journal of pharmacology 1986;127(3):187-95.
1986: R Laufer; Chaim Gilon; Michael Chorev; Zvi Selinger
Characterization of a neurokinin B receptor site in rat brain using a highly selective radioligand.
The Journal of biological chemistry 1986;261(22):10257-63.
1986: R Laufer; Chaim Gilon; Michael Chorev; Zvi Selinger
[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.
Journal of medicinal chemistry 1986;29(7):1284-8.
1986: Ariel Ewenson; R Laufer; Michael Chorev; Zvi Selinger; Chaim Gilon
Ketomethylene pseudopeptide analogues of substance P: synthesis and biological activity.
Journal of medicinal chemistry 1986;29(2):295-9.
1985: Z Y Friedman; Uri Wormser; E Rubini; Michael Chorev; Chaim Gilon; Zvi Selinger
Desensitization of substance P-induced K+ release in rat parotid.
European journal of pharmacology 1985;117(3):323-8.
1985: R Laufer; Uri Wormser; Z Y Friedman; Chaim Gilon; Michael Chorev; Zvi Selinger
Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(21):7444-8.
1985: R Laufer; Ariel Ewenson; Chaim Gilon; Michael Chorev; Zvi Selinger
Inhibition of substance P degradation in rat brain preparations by peptide hydroxamic acids.
European journal of biochemistry / FEBS 1985;150(1):135-40.
1984: R Laufer; Uri Wormser; Zvi Selinger; Michael Chorev; Chaim Gilon
Ion-exchange chromatographic assay of peptidases acting on the C-terminal hexapeptide sequence of substance P.
Journal of chromatography 1984;301(2):415-24.
1984: Uri Wormser; Michael Chorev; Chaim Gilon; R Laufer; Z Y Friedman; Zvi Selinger
Substance P degrading systems of rat parotid and hypothalamus.
Biochimica et biophysica acta 1984;798(1):28-36.
1983: Michael Chorev; E Rubini; Chaim Gilon; Uri Wormser; Zvi Selinger
Synthesis of partially modified retro-inverso substance P analogues and their biological activity.
Journal of medicinal chemistry 1983;26(2):129-35.
1981: R Laufer; Michael Chorev; Chaim Gilon; Z Y Friedman; Uri Wormser; Zvi Selinger
Persistent action of N-methylated analogs of substance P on rat parotid slices.
FEBS letters 1981;123(2):291-4.